Polypeptide

Polypeptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Alysine monomethylated derivative and corresponding antibody and use thereof
May 25, 2017 - N°20170146550

Provided are artificially synthesized modified mono-methylated lysines and modified mono-methylated lysine derivatized polypeptides. Also provided is an antibody produced by using this modified mono-methylated lysine and modified monomethylated lysine derivatized polypeptide as an antigen, the antibody can be used in recognizing and enriching the modified polypeptide after the lysine mono-methylated polypeptide being derivatized in vitro. Also provided are a preparation ...
NEW Rp-hplc analysis of complex polypeptide mixtures
May 25, 2017 - N°20170146547

The present invention relates to reversed phase high-performance liquid chromatography (hplc) methods useful for the characterisation of glatiramer acetate or similar polypeptide mixtures. The method described herein can distinguish glatiramer acetate from non-conforming copolymers and may be used to choose batches of glatiramer acetate suitable for pharmaceutical use.
NEW Compositions, kits and methods for in vitro antigen presentation, assessing vaccine efficacy, and assessing immunotoxicity ...
May 25, 2017 - N°20170146526

Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional apcs (papcs) result in the generation of autologous apcs that present a natural peptide repertoire of the antigen for use in assessing the efficacy of a vaccine (e. G., a cytotoxic t lymphocyte (ctl) response to a particular ...
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NEW Methods for producing polypeptides in enzyme-deficient mutants of fusarium venentatum
May 25, 2017 - N°20170145462

The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent fusarium venenatum strain in a medium for the production of the polypeptide, wherein the mutant strain comprises a polynucleotide encoding the polypeptide and one or more (several) genes selected from the group consisting of pyrg, amya, and alpa, wherein the one or ...
NEW Protein production in microorganisms of the phylum labyrinthulomycota
May 25, 2017 - N°20170145461

The present invention relates to recombinant cells and microorganisms of the phylum labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
NEW Plants having increased tolerance to heat stress
May 25, 2017 - N°20170145435

The invention relates to methods of producing a desired phenotype in a plant by manipulation of gene expression within the plant. The method relates to means which increase the level of expression of a myb-subgroup14 polynucleotide or a myb68 polypeptide. The method also relates to expression of a nucleic acid sequence encoding a myb-subgroup14 or a myb68 transcriptional factor. The ...
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NEW Modular construction of synthetic gene circuits in mammalian cells using tale transcriptional repressors
May 25, 2017 - N°20170145426

Provided is a modular construction of synthetic gene circuits in mammalian cells using tale transcriptional repressors. Provided is a method for achieving regulated expression of two proteins: an expression cassette a comprises a feedback element coding sequence, a promoter a, a protein a and taler protein a encoding gene linked by means of a self-cleaving polypeptide, and a target sequence ...
NEW Methods for increasing the diversity of monoclonal antibodies produced against an antigen
May 25, 2017 - N°20170145407

The present invention relates to methods for increasing the diversity of monoclonal antibodies produced against an antigen. The methods of the invention utilize immunization of a murine host defective in one or more enzymes involved in a post-translational modification of a polypeptide or a modification of a lipid, wherein said modification is exposed on a cell surface. The invention also ...
NEW Expression of polypeptides involved in lysine decarboxylation, and methods and applications thereof
May 25, 2017 - N°20170145403

The expression plasmid vectors comprise a polynucleotide sequence encoding ldc2 polypeptide, a fragment, and/or a mutant. A backbone plasmid is capable of autonomous replication in a host cell. The host cell is not a p. Aeruginosa cell. Transformants are transformed with expression plasmid vector. The transformants are not p. Aeruginosa. Mutant host cells comprise a polynucleotide sequence encoding ldc2 ...
NEW Polypeptides having xylanase activity and polynucleotides encoding same
May 25, 2017 - N°20170145397

The present invention relates to isolated polypeptides having xylanase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules.
NEW Polypeptides having xylanase activity and polynucleotides encoding same
May 25, 2017 - N°20170145395

The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
NEW Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9
May 25, 2017 - N°20170145394

Cas9 polypeptides which target rna and methods of using them are provided.
NEW Npp1 fusion proteins
May 25, 2017 - N°20170145393

The present invention provides a novel fusion polypeptide containing a catalytic domain of npp1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.
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NEW Omega-hydroxylase-related fusion polypeptides with improved properties
May 25, 2017 - N°20170145390

The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for ex pressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
NEW Mesenchymal stem cells derived from induced pluripotent stem cells
May 25, 2017 - N°20170145385

A method of producing mesenchymal stem cells from induced pluripotent stem cells in which induced pluripotent stem cells are cultured in the presence of a tgf-βinhibitor an in an atmosphere containing from about 7 vol. % to about 8 vol. % c02 for a period of time from about 20 day to about 35 days. The cells then are transfered to a culture ...
NEW Method of preparing white liquor flavored enhancing peptide
May 25, 2017 - N°20170145360

The present invention discloses a preparation method of liquor flavor-enhancing peptide, comprising the following steps: defatted soybean meal and chloroform/ethanol are mixed uniformly; after treated by colloid mill and centrifuge, the obtained precipitate is the defatted soybean meal removal of the alcohol-soluble components; and then 55% (v/v) of ethanol aqueous solution and protease are added therein; the supernatant is ...
NEW Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants
May 25, 2017 - N°20170145108

Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated ...
NEW Predicting response to cancer treatment with fgfr2 inhibitors
May 25, 2017 - N°20170145103

Provided herein are uses of fibroblast growth factor receptor 2 (fgfr2) inhibitors in cancer treatment, in some cases in combination with immune stimulating agents, such as inhibitors of pd-1 or pd-l1. In some embodiments, fgfr2 inhibitors may comprise fgfr2 antibodies or fgfr2 extracellular domain (ecd) polypeptides, or fgfr2 ecd fusion molecules comprising an fgfr2 ecd and a fusion partner. In some ...
NEW Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment
May 25, 2017 - N°20170145102

Provided herein are uses of fibroblast growth factor receptor 2 (fgfr2) inhibitors in cancer treatment, in some cases in combination with immune stimulating agents, such as inhibitors of pd-1 or pd-l1. In some embodiments, fgfr2 inhibitors may comprise fgfr2 antibodies or fgfr2 extracellular domain (ecd) polypeptides, or fgfr2 ecd fusion molecules comprising an fgfr2 ecd and a fusion partner. In some ...
NEW Method for purifying active polypeptides or immunoconjugates
May 25, 2017 - N°20170145100

The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
NEW Chimeric antigen receptor and its use
May 25, 2017 - N°20170145095

In a first aspect, the present invention relates to a recombinant polypeptide containing a domain comprising at least two antibody units whereby the first antibody unit is an anti-cd30 single chain antibody unit while the second antibody unit is a antibody unit being specific for an antigen present on the surface of a predetermined target cell. In particular, the present ...