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Polypeptide

Polypeptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Compositions comprising a polypeptide having cellulolytic enhancing activity and a quinone compound and uses thereof
Novozymes, Inc.
January 18, 2018 - N°20180019412

The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a quinone compound. The present invention also relates to methods of using the compositions.
NEW Assay and method for determining cdc eliciting antibodies
Hoffmann-la Roche Inc.
January 18, 2018 - N°20180017572

Herein is reported a method for determining complement dependent cytotoxicity of a composition comprising i) a first binding site that specifically binds to a first epitope on a first antigen, which is conjugated to a first fc-region polypeptide of human origin, and ii) a second binding site that specifically binds to a second epitope on a second antigen, which is ...
NEW Tobacco mosaic virus resistant n'au gene and cloning methods and applications thereof
Yunnan Academy Of Tobacco Agricultural Sciences
January 18, 2018 - N°20180016595

The invention relates to the isolation and the cloning and breeding application of a tobacco mosaic virus (tmv) resistant n'au gene. The invention discloses the nucleotide sequence of the tmv resistant n'au gene shown as seq id no. 1. The amino acids of polypeptide encoded by the tmv resistant n'au gene are shown as seq id no. 2. A non-transgenic tmv resistant ...
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NEW Yeast cells expressing amyloid beta and uses therefor
Whitehead Institute For Biomedical Research
January 18, 2018 - N°20180016588

Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as ...
NEW L-arabinose assimilation pathway and uses thereof
Deinove
January 18, 2018 - N°20180016586

The present invention relates to a new l-arabinose assimilation pathway and uses thereof. In particular, the present invention relates to polypeptides exhibiting l-arabinose isomerase, l-ribulokinase or l-ribulose-5-phosphate-4-epimerase activity, and recombinant host cells expressing said polypeptides. The present invention also relates to a method of producing a fermentation product, preferably ethanol, from an arabinose containing substrate, using a polypeptide ...
NEW Engineered phenylalanine ammonia lyase polypeptides
Codexis, Inc.
January 18, 2018 - N°20180016568

The present invention provides engineered phenylalanine ammonia-lyase (pal) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (pal) polypeptides.
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NEW Alpha-glucosidase, compositions & methods
Danisco Us Inc.
January 18, 2018 - N°20180016563

The present disclosure relates to polypeptides having alpha-glucosidase activity isolated, derived or derivable from rasamsonia or engineered polypeptides having alpha-glucosidase activity isolated, derived or derivable from rasamsonia homologs. The present disclosure also pertains to polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, host cells and mutant cells comprising the polynucleotides. The disclosure further pertains to compositions comprising such polypeptides, methods ...
NEW Ancestral proteins
Georgia Tech Research Corporation
January 18, 2018 - N°20180016562

The invention provides a method tar increasing the stability and/or activity of a polypeptide at low ph and/or elevated temperatures the invention farther provides a method for increasing the melting temperature of a polypeptide. Also provided are paleoenzymologically reconstructed thioredoxin polypeptides having activity at higher temperatures and/or lower ph than extant thioredoxin polypeptides, as well as paleoenzymologically ...
NEW Antibodies comprising sequences from camelidae to highly conserved targets
Argen-x N.v.
January 18, 2018 - N°20180016351

The present invention is concerned with antigen binding polypeptides, and in particular conventional antibodies derived from camelid species, that specifically bind to target antigens that are either self-antigens or highly conserved antigens. The present invention also relates to anti-idiotype antigen binding peptides which bind to a target antigen comprising the variable region of an antibody obtained from a species within ...
NEW Multivalent molecules comprising dr5-binding domains
Macrogenics, Inc.
January 18, 2018 - N°20180016344

The present invention is directed to multivalent dr5-binding molecules that comprise binding domain(s) of anti-dr5 antibodies, and particularly binding domain(s) of anti-human dr5 antibodies. The dr5-binding molecules of the present invention include bivalent and tetravalent molecules having two, three or four dr5-binding domains each capable of binding human dr5. In particular, the present invention is ...
NEW Interleukin-6 receptor binding polypeptides
Ablynx N.v.
January 18, 2018 - N°20180016342

The invention relates to amino acid sequences that are directed against and/or that can specifically bind to il-6 receptor, compounds or constructs that comprise the amino acid sequence, nucleic acids that encode the amino acid sequences, compounds or constructs, pharmaceutical compositions comprising the amino acid sequences, compounds or constructs as well as methods for the prevention and/or treatment ...
NEW Anti-tau constructs
Washington University
January 18, 2018 - N°20180016328

The present invention provides anti-tau constructs. Anti-tau constructs of the invention are polynucleotide sequences encoding a polypeptide comprising at least one tau binding moiety and optionally comprising a signal peptide and/or a purification moiety. The present invention also provides isolated polypeptides encoded by anti-tau constructs, vectors comprising anti-tau constructs, and isolated cells comprising said vectors.
NEW Modified dkk2 protein, nucleic acid encoding the same, preparation method thereof, and use thereof
Medpacto Inc.
January 18, 2018 - N°20180016313

Provided are a modified dkk2 polypeptide according to an aspect, a nucleic acid encoding the same, a preparation method thereof, and use thereof. Accordingly, a modified dkk2 protein having an additional glycosyl group or improved binding affinity for a substrate lrp6 may be efficiently prepared, thereby being used for promoting angiogenesis or preventing or treating vascular permeability-related diseases.
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NEW Griffithsin mutants
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
January 18, 2018 - N°20180016307

The invention provides modified griffithsin polypeptides comprising the amino acid sequence of seq id no: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
NEW Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
Angiochem Inc.
January 18, 2018 - N°20180015180

The present invention relates to short polypeptides (e. G., fewer than 19 amino acids in length) and longer polypeptides (e. G., 19 or more amino acids in length) having one or more d-amino acids as targeting moieties. These polypeptides, when conjugated to agents (e. G., therapeutic agents or transport vectors) are capable of transporting the agents across the bbb or into particular ...
NEW Cancer methods
January 18, 2018 - N°20180015163

A method of treating a patient having a cancer in which her2, her4, fgfr1, epha2 and/or fgfr3 is upregulated and/or in which her2, her4, fgfr1, epha2 and/or fgfr3 mediated-signaling is upregulated, the method comprising administering to the patient a compound comprising or consisting of an opcml polypeptide (seq id no: 1), or a fragment thereof which comprises at ...
NEW Methods and compositions for improved cognition
The Regents Of The University Of California
January 18, 2018 - N°20180015151

Provided herein are klotho polypeptide compositions and methods for improving cognitive function in an individual comprising treatment of with klotho polypeptides.
Identification of the presence of specific polypeptides by liquid chromatography and mass spectrometry
Genysis Lab Inc.
January 11, 2018 - N°20180011107

Disclosed are methods for determining the presence of one or more proteins in a sample, the methods comprising: enzymatically digesting the sample with a protease activity to generate a plurality of proteolytic peptides; separating the plurality of proteolytic peptides using liquid chromatography; performing mass spectrometry on the separated plurality of peptides; and wherein a protein is present in the sample ...
Hcv ns4a/modified ns3 polypeptides and uses thereof
Grifols Worldwide Operations Limited
January 11, 2018 - N°20180011096

Modified hepatitis c virus polypeptides are described. The polypeptides include the hcv ns4a domain and modified ns3 domain. The polypeptides retain conformational epitopes. Hcv immunoassays including the polypeptides are also described.
Assessing retinal pigment epithelial cell populations
Cell Cure Neurosciences Ltd.
January 11, 2018 - N°20180011092

A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (pmel17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (cralbp), lecithin retinol acyltransferase (lrat) and sex determining region y-box 9 (sox 9) in the population of cells.
Novel dna-binding proteins and uses thereof
Sangamo Therapeutics, Inc.
January 11, 2018 - N°20180010152

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel dna-binding domains, including tale dna-binding domains. Also disclosed are methods of using these novel dna-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
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