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Polypeptide patents



      
           
This page is updated frequently with new Polypeptide-related patents. Subscribe to the Polypeptide RSS feed to automatically get the update: related Polypeptide RSS feeds.

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Date/App# patent app List of recent Polypeptide-related patents
04/10/14
20140101793
 Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same patent thumbnailPolypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/10/14
20140101785
 Genetically encoded calcium indicators and methods of use patent thumbnailGenetically encoded calcium indicators and methods of use
Genetically encoded calcium indicator (geci) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of g-protein coupled receptor (gpcr) or ion channels and methods of monitoring neural activity also are provided..
04/10/14
20140100836
 Rational design of components of the oligo-saccharyltransferase-catalysed asparagine-linked glycosylation patent thumbnailRational design of components of the oligo-saccharyltransferase-catalysed asparagine-linked glycosylation
The present invention is directed to methods for identifying or designing (a) a potential oligosaccharide donor, (b) a potential oligosaccharyltransferase (ost), (c) a potential consensus sequence motif polypeptide, and/or (d) a potential glycosylation inhibitor for use in the oligosaccharyltransferase (ost)-catalysed asparagine-linked (“n-linked”) glycosylation, comprising the steps of generating a three-dimensional model of the catalytic domain and/or the polypeptide binding site of the oligosaccharyltransferase (ost) of campylobacter lari, and designing or selecting a potential component selected from (a) to (d) which optimizes the stereo chemical complementarity of said three-dimensional model(s) and the potential component.. .
04/10/14
20140100357
 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides patent thumbnailCompositions containing, methods involving, and uses of non-natural amino acids and polypeptides
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group.
04/10/14
20140100356
 Novel immunoglobulin-binding polypeptide patent thumbnailNovel immunoglobulin-binding polypeptide
An object of the present invention is to provide novel polypeptides that are capable of binding to an immunoglobulin and have high stability against alkali. The present invention relates to proteins having the amino acid sequence of seq id no:1 or 2..
04/10/14
20140100127
 Liver cancer diagnosis marker and use thereof patent thumbnailLiver cancer diagnosis marker and use thereof
A marker for the detection of liver cancer and application of the marker thereof. The application includes use of cytochrome p450 family 17 subfamily a polypeptide 1 (cyp17a1 protein) in the preparation of diagnostic reagents or kits for the detection of liver cancer kit.
04/10/14
20140099724
 Fluorescent detection of in vitro translated protein on a solid surface patent thumbnailFluorescent detection of in vitro translated protein on a solid surface
Disclosed herein are methods and kits useful in the detection of protein folding and in the identification of compounds that promote proper protein folding. In one example approach, fluorophores and a protein tag are incorporated into a nascent polypeptide within a ribosome-nascent-chain complex during cell free translation and the resulting labeled ribosome-nascent-chain complex is conjugated to a solid surface via the tag.
04/10/14
20140099707
 Antibody polypeptides that antagonize cd40l patent thumbnailAntibody polypeptides that antagonize cd40l
Antibody polypeptides that specifically bind human cd40l are provided. The antibody polypeptides do not activate platelets.
04/10/14
20140099666
 Compositions and methods for enhancing production of a biological product patent thumbnailCompositions and methods for enhancing production of a biological product
The invention provides compositions and methods for producing a biological product from a host cell. In various embodiments, the biological product is a polypeptide, a metabolite, a nutraceutical, a chemical intermediate, a biofuel, a food additive, or an antibiotic.
04/10/14
20140099444
 Composites containing polypeptides attached to polysaccharides and molecules patent thumbnailComposites containing polypeptides attached to polysaccharides and molecules
This document provides methods and materials related to composites or coatings containing polypeptides attached to polysaccharides and/or molecules. For example, methods and materials related to composites or coatings containing polypeptides (e.g., casein polypeptides) attached to polysaccharides (e.g., cellulose) and/or molecules (e.g., calcium containing molecules such as calcium phosphate and calcium carbonate and/or polyesters such as polylactic acid and polyhydroxybutyrate) are provided.
04/10/14
20140099401
Asparaginase enzyme variants and uses thereof
The present invention relates to newly identified asparaginase polypeptide variants of seq id no: 3 and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes..
04/10/14
20140099335
Dna vaccine
The present invention provides a therapeutic or improving agent for a lifestyle-related disease, containing an expression vector encoding a chimeric hepatitis b virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of the lifestyle-related disease-related factor, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis b virus core antigen polypeptide.. .
04/10/14
20140099317
Antibody polypeptides that antagonize cd40
Antibody polypeptides that specifically bind a novel epitope of human cd40 are provided. The antibody polypeptides do not exhibit cd40 agonist activity.
04/10/14
20140099314
S. aureus polypeptide and antibodies
The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to manufacture said polypeptides, vaccines and antibodies.. .
04/10/14
20140099307
New dendritic cell co-stimulatory molecules
A novel costimulatory protein molecule, b7-dc, which is a member of the b7 family, is described as is dna coding therefor and expression vectors comprising this dna. B7-dc protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing b7-dc are useful in vaccine compositions and methods.
04/10/14
20140099297
Ace2 polypeptide
The present invention relates to recombinant ace2 polypeptide, where the ace2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
04/10/14
20140099294
Biotherapy for pain
The present invention is directed to analgesic clostridial neurotoxin derivatives comprising polypeptides having a long-lasting snare protein-selective endopeptidase activity. These derivatives selectively bind to and are internalized by non-neuronal cells secreting cytokines or sensory neurons in preference to motor neurons or autonomic neurons.
04/10/14
20140099280
Novel superactive il-33 fragments, and uses thereof
The present invention discloses novel active polypeptide fragments of human il-33 corresponding to natural forms generated by the proteases of human neutrophils (cathepsin g, elastase 2, proteinase 3), as well as the use thereof as a drug, in particular for the treatment of infectious diseases, inflammatory diseases, atherosclerosis, cardiovascular diseases, obesity, or cancer.. .
04/10/14
20140097086
Methods for production of proteins
The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies thereby facilitating rapid isolation and purification of recombinant proteins.
04/03/14
20140096287
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/03/14
20140096283
Plants having enhanced yield-related traits and a method for making the same
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a tcp1 or a tcp2 transcription factor, an epsin-like polypeptide, a trna delta(2)-isopentenylpyrophosphate transferase (ippt) polypeptide, or a short-root (shr) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a tcp1 or tcp2 polypeptide, an epsin-like polypeptide, a trna delta(2)-isopentenylpyrophosphate transferase (ippt) polypeptide, or a short-root (shr) polypeptide, which plants have enhanced yield-related traits relative to corresponding wild type plants or other control plants.
04/03/14
20140096281
Axmi232, axmi233, and axmi249 toxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
04/03/14
20140094466
Ssh-2 (slingshot-2) inhibitors and methods for making and using them
In alternative embodiments, the invention provides compositions that inhibit the polypeptide ssh-2, or slingshot-2, a phosphatase enzyme that regulates actin filaments, and methods for making and using them, including methods comprising administering compositions of the invention to regulate or modify actin filament polymerization by inhibiting ssh-2, where in one embodiment compositions of the invention slow or inhibit f-actin depolymerization and severing. In alternative embodiments, compositions and methods of the invention are used to slow or inhibit cell motility and/or internal remodeling.
04/03/14
20140094401
Mitrecin a polypeptide with antimicrobial activity
The present invention provides a mitrecin a polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a mitrecin a polypeptide.
04/03/14
20140094384
Stromal antigen 2 (stag2) compositions and methods
Compositions and methods related to stromal antigen 2 (stag2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.. .
04/03/14
20140093965
Expression systems and methods of producing spider silk proteins
An expression system, including a host cell, a synthetic spider silk polypeptide-encoding nucleotide sequence, at least one synthetic trna molecule-encoding nucleotide sequence or a synthetic serine hydroxymethyl transferase (shmt)-encoding nucleotide sequence.. .
04/03/14
20140093956
Modified human thymic stromal lymphopoietin
Modified, furin resistant human tslp polypeptides and polynucleotides encoding the modified human tslp polypeptides are provided. Pharmaceutical compositions, b and t cell activation agents, assays and methods of use are also described..
04/03/14
20140093941
Prokaryotic rnai-like system and methods of use
Provided herein are methods for inactivating a target polynucleotide. The methods use a psirna having a 5′ region and a 3′ region.
04/03/14
20140093940
Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
04/03/14
20140093936
Type ii restriction modification system methylation subunit of alicyclobacillus acidocaldarius
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from alicyclobacillus acidocaldarius..
04/03/14
20140093930
Polypeptides with ketol-acid reductoisomerase activity
Polypeptides having ketol-acid reductoisomerase activity are provided. Also disclosed are recombinant host cells comprising isobutanol biosynthetic pathways employing such polypeptides.
04/03/14
20140093927
Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria
Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria are described. Additionally, variant or recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided..
04/03/14
20140093919
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/03/14
20140093892
Marker comprising anti-ck8/18 complex autoantibody and its use for diagnosing cancer
The present invention relates to a cytokeratin 8/18 complex-specific autoantibody or a fragment comprising an antigen-binding site (paratope) thereof, the use thereof in the diagnosis of breast cancer, a polypeptide having an amino acid sequence of an epitope specifically binding to the autoantibody, a composition for diagnosing breast cancer comprising an agent capable of measuring an expression level of the autoantibody or the fragment comprising an antigen-binding site thereof, a hybridoma cell line producing the autoantibody, and a kit for diagnosing breast cancer comprising the composition of the present invention. Further, the present invention relates to a method for diagnosing breast cancer, comprising the step of detecting the cytokeratin 8/18 complex-specific autoantibody or the fragment comprising the antigen-binding site thereof using the composition of the present invention, and a method for screening a therapeutic agent for breast cancer using the autoantibody..
04/03/14
20140093888
Highly pure plasmid dna preparations
The present disclosure generally relates to highly pure plasmid compositions having low, or undetectable, levels of colanic acid and other contaminants made by a process that includes the steps of obtaining a crude lysate of a plasmid dna from a bacteria that makes colanic acid; treating the partially purified or purified plasmid dna with a polypeptide that digests colanic acid under conditions that digest the colanic acid; and purifying the plasmid dna from the digested colanic acid and the colanic acid degrading enzyme by one or more chromatography steps.. .
04/03/14
20140093540
Immunogenic compositions and expression systems
Immunogenic compositions and vaccines against plasmodial infection comprising an rh polypeptide or a fragment or variant thereof are disclosed. Also disclosed are rh5 polypeptides or fragments or variants thereof capable of binding cd147 and conferring protection against infection and/or disease caused by multiple plasmodial strains or plasmodial species, inhibitors of the interaction between rh5 and cd147 and methods for producing polypeptides in a mammalian expression system..
04/03/14
20140093534
Compositions and methods of enhancing immune responses
Provided herein are salmonella enteritidis 13a strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against influenza a and methods of reducing morbidity associated with an influenza a infection.
04/03/14
20140093533
Polypeptides and vectors for targeting her2/neu expressing cells and uses thereof
Various aspects of the invention provide for capsids, parvovirus capsids, hybrid parvovirus capsids, parvovirus vectors, hybrid parvovirus vectors, hybrid parvovirus particles and parvovirus particles containing polypeptides in which the sequence ycdgfyacymdv (seq id no: 3) has been substituted into the vp2 loop of the b19 capsid protein. Polypeptides in which the sequence ycdgfyacymdv (seq id no: 3) has been substituted into the vp2 loop of the b19 capsid protein are also provided (e.g., seq id no: 2).
04/03/14
20140093532
Immunogenic compositions in particulate form and methods for producing the same
The invention relates to the field of immunology and vaccine development, in particular to the development of vaccines based on native antigen oligomers. Provided is an immunogenic composition in particulate form, comprising oligomers of a surface exposed polypeptide of pathogenic origin or tumour origin, or antigenic part thereof, said oligomers being bound non-covalently to a particulate carrier, and a pharmaceutically acceptable diluent or excipient.
04/03/14
20140093531
Lutzomyia longipalpis polypeptides and methods of use
Substantially purified salivary lu. Longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed.
04/03/14
20140093528
Deletion of the beta 20-21 loop in hiv gp120 exposes the cd4 binding site for improved antibody binding and antibody induction
Disclosed herein are isolated immunogens including variant gp120 polypeptides. In an example, a variant gp120 polypeptide includes a deletion of at least 8 consecutive residues of the fourth conserved loop (c4) between residues 419 and 434 of gp120 according to hxb2 numbering.
04/03/14
20140093524
Modified chaperonin 10
The present invention relates to isolated chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.. .
04/03/14
20140093496
Fc-gamma-riib-specific fc antibody
An objective of the present invention is to provide a polypeptide containing an fc region having maintained or decreased binding activities towards both allotypes of fcγriia, types h and r, and having enhanced fcγriib-binding activity in comparison with a parent polypeptide; a pharmaceutical composition containing the polypeptide; an agent for treating or preventing immunological inflammatory diseases that includes the pharmaceutical composition; a production method thereof; and a method for maintaining or decreasing binding activities towards both allotypes of fcγriia and enhancing the fcγriib-binding activity. Specifically, it is found that a polypeptide containing an antibody fc region that has an alteration of substituting pro at position 238 (eu numbering) with asp or leu at position 328 (eu numbering) with glu enhances fcγriib-binding activity, and maintains or decreases binding activities towards both allotypes of fcγriia, types h and r.
04/03/14
20140093477
Modulating bacterial mam polypeptides in pathogenic disease
The disclosure relates to methods and compositions for preventing or inhibiting pathogenic bacterial infections in a subject caused by pathogenic bacteria expressing a multivalent adhesion molecule (mam) polypeptide by administering to a subject a composition comprising a mam polypeptide or a non-pathogenic bacterium expressing a mam polypeptide, or a combination thereof.. .
03/27/14
20140090114
Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
Recombinant polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
03/27/14
20140090110
Plants having enhanced yield-related traits and method for making the same
Provided is a method for enhancing yield-related traits in plants by increasing expression in plants of a nucleic acid encoding a low sulfur upregulated polypeptide (lsu). Also provided are plants having increased expressing of a nucleic encoding an lsu polypeptide, which have enhanced yield-related traits compared with control plants.
03/27/14
20140090103
Methods and compositions for increasing plant disease resistance and yield
The present invention discloses novel plant homologs of the arabidopsis peptide atpep1. Atpep peptides in arabidopsis are involved in the amplification of defense pathways involved in innate immunity against microbial pathogens.
03/27/14
20140090094
Modulators of slc22a7
The present invention is directed to the identification of modulators for slc22a7 transporter and therapeutic uses thereof. Hence, in one embodiment the present invention relates to a method for identifying and/or obtaining a compound capable of modulating glutamate transport, comprising contacting a test compound with a system for measuring those transport activity, which system comprises an slc22a7 polypeptide or a functional fragment thereof, and a substrate for measuring glutamate transport by the system; and detecting an altered level of the those transport activity of the slc22a7 polypeptide or functional fragment in the presence of the test compound compared to the described transport activity in the absence of the test compound and/or presence of a control..
03/27/14
20140088293
Photosynthetic organisms and compositions and methods of generating same
An isolated polynucleotide is provided. The isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide of a type ii reaction center of a photosynthetic organism, the nucleic acid sequence being capable of imparting the type ii reaction center with an activity under a temperature range different than that of the type ii reaction center endogenous to the photosynthetic organism.
03/27/14
20140088292
Water-soluble polypeptides comprised of repeat modules, method for preparing the same and method for a target-specific polypeptide and analysis of biological activity thereof
The present invention relates to a soluble polypeptide comprised of repeat modules. More particularly, the present invention relates to a soluble fusion polypeptide of the n-terminal domain of internalin and lrr (leucine rich repeat) family protein, a method for preparing the polypeptide, a vector comprising a nucleic acid sequence encoding the polypeptide, a host cell comprising the vector, a method for producing a solubility and folding-improved fusion polypeptide by expressing the vector in the host cell, and a method for improving the solubility and folding of the fusion polypeptide.
03/27/14
20140088015
Mucin 3 egf-like domains
The invention provides for a mucin3 polypeptide, a polypeptide including a mucin3 egf like domain, and nucleic acids encoding such polypeptides. The invention also provides for methods of treating an individual that has or is at risk of developing a disease or condition of the alimentary canal using such polypeptides or nucleic acids..
03/27/14
20140088013
Complexation of metal ions with polypeptides
Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle.
03/27/14
20140088009
Chimeric neuregulins and method of making and use thereof
Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, erb 3, or erb 4 comparing to that of the first neuregulin..
03/27/14
20140088008
Novel activin receptor and uses thereof
The present invention provides novel activin iib5 receptor polypeptides capable of binding and inhibiting the activities of activin a, myostatin, or gdf-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides.
03/27/14
20140088003
Polymer-based sustained release device
This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar..
03/27/14
20140087998
Use of pacap for the treatment viral infections in aquatic organisms
The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (pacap) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. Pacap, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths.
03/27/14
20140087995
Polypeptides
The invention relates to polypeptides comprising an amino acid sequence which is an analogue of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.. .
03/27/14
20140087969
Pim-3 kinase as a target for type 2 diabetes mellitus
The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having pim-3 activity and having a definite amino acid sequence, as well as to the use of pim-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus..
03/27/14
20140087423
Method for controlling the main complex n-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
The present invention relates to a method of controlling quality and quantity of posttranslational modification of a recombinantly produced polypeptide/protein (glycoprotein), wherein the posttranslational modification affects the glycosylation profile and/or the acidic variants profile, as manifested in cex profiles, wherein the polypeptide/protein (glycoprotein) production is in eukaryotic host cells, the method comprising the following steps: a) cultivating the eukaryotic cells in a suitable medium under conditions which allow the expression of the polypeptide/protein, wherein the content of the dissolved co2 (pco2) in the medium is at a first value during the initial growth phase of the eukaryotic cells, allowing the eukaryotic cells to grow, and b) increasing or decreasing the content of the dissolved co2 (pco2) in the medium during the production phase of the eukaryotic cells to a second value.. .
03/27/14
20140087422
Nucleic acids related to fusion proteins
The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated igg (aig) and immune complex function with respect to their interactions with fcγr and which allow for the inclusion and targeting of a second protein domain to cells expressing fcγr. This was accomplished by expressing multiple linear copies of the hinge and ch2 domains (hch2) of human igg1 fused to the framework region of human igg1.
03/27/14
20140087002
Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat lymphedema and to improve reconstructive surgery
Materials and methods are provided to improve survival of lymph nodes and integration of lymph nodes into a lymphatic network, following lymph node transplantation. The treatment or prevention of lymphedema is also addressed.
03/27/14
20140086953
Attenuated chikungunya virus
Novel attenuating deletions of chikungunya virus e2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic compositions comprising the attenuated viruses and methods of producing such viruses in cells (such as insect cells).
03/27/14
20140086949
Ghrelin mimetic polypeptide hapten immunoconjugates having improved solubility and immunogenicity and methods of use thereof
Immunoconjugates for impeding weight gain and treating obesity in a subject are disclosed. The immunoconjugates comprise a ghrelin mimetic polypeptide hapten, a spacer moiety comprising one of more polyethylene glycol (peg) units, and a protein carrier moiety.
03/27/14
20140086948
Tuberculosis rv2386c protein, compositions and uses thereof
The present invention is directed to a polypeptide which comprises: (i) an rv2386c protein sequence; (ii) a variant of an rv2386c protein sequence; of (iii) an immunogenic fragment of an rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis..
03/27/14
20140086944
Dna vaccine containing specific epitope of apolipoprotein (a)
The present invention provides an agent for the treatment or prophylaxis of arteriosclerosis comprising an expression vector encoding a chimeric hepatitis b virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of apolipoprotein (a), wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis b virus core antigen polypeptide.. .
03/27/14
20140086920
Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8 associated disorders
The disclosure provides novel molecules related to growth and differentiation factor-8 (gdf-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit gdf-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (als).
03/27/14
20140086916
Method for preparing fc containing polypeptides having improved properties
The present invention is directed to methods and compositions for the production of fc-containing polypeptides comprising mutations at positions 243, 264, 267 and 328 of the fc region.. .
03/27/14
20140086897
Chimeric neuregulins and method of making and use thereof
Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, erb 3, or erb 4 comparing to that of the first neuregulin..
03/27/14
20140086895
Methods and pharmaceutical compositions for the treatment of autoimmune diseases
The present invention relates to methods and pharmaceutical compositions for the treatment of autoimmune diseases, especially rheumatoid arthritis. More particularly, the present invention relates to an a-enolase polypeptide for use in the prophylactic treatment of an autoimmune disease in a subject in need thereof..
03/27/14
20140086874
Biomaterial, method for making the biomaterial and uses of the same
A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction cs, and a precipitated fraction cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor.
03/27/14
20140086871
Ultralong complementarity determining regions and uses thereof
Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (cdr3h) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the cdr3h.
03/27/14
20140086842
Screening methods using g-protein coupled receptors and related compositions
The present invention provides screening methods for gpcrs based on the discovery that the affinity of a receptor agonist for a gpcr (such as the parathyroid hormone receptor) when not bound to a g-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides pth- and pthrp-derived polypeptides..


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