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Polypeptide

Polypeptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for detecting aggregate form of aggregate-forming polypeptide
Peoplebio, Inc.
September 14, 2017 - N°20170261521

The present invention relates to a method for detecting an aggregate form of an aggregate-forming polypeptide in a biosample, comprising the steps of: (a) spiking, in a biosample to be analyzed, (i) a monomeric or multimeric form of an aggregate-forming polypeptide, (ii) a hydrophobic deleted derivative of the aggregate-forming polypeptide, or (iii) a monomeric or multimeric form of the aggregate-forming ...
Cell surface display, screening and production of proteins of interest
Agenus Inc.
September 14, 2017 - N°20170261506

Aspects of the invention provide compositions and methods for displaying engineered polypeptides on a cell surface. According to aspects of the invention, immobilized polypeptides can be screened to identify one or more variants having one or more functional or structural properties of interest. Aspects of the invention provide composition and methods for producing engineered protein or protein variants having a ...
Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays
Roche Diagnostics Operations, Inc.
September 14, 2017 - N°20170261498

The invention concerns a fusion polypeptide comprising several molecules of folding helper polypeptides, comprising one multimerization domain, in particular skp, and at least one molecule of slyd or slpa, wherein no further target polypeptide sequences are fused to said fusion polypeptide. The invention further concerns an immunoassay and the use of said fusion polypeptide in an immunoassay for reduction of ...
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Microorganism producing o-phosphoserine and a method for producing o-phosphoserine or l-cysteine using the same
Cj Cheiljedang Corporation
September 14, 2017 - N°20170260556

The present invention relates to a microorganism, wherein the activity of a polypeptide capable of exporting o-phosphoserine (ops) is enhanced, and a method of producing o-phosphoserine, cysteine, or a cysteine derivative using the microorganism.
Plants having increased tolerance to herbicides
Basf Se
September 14, 2017 - N°20170260540

The present invention refers to a plant or plant part comprising a polynucleotide encoding a wildtype or mutated cellulose synthase (cesa) polypeptide, the expression of said polynucleotide confers to the plant or plant part tolerance to cesa-inhibiting herbicides, such as azines.
Coexpression plasmid
Anaeropharma Science, Inc.
September 14, 2017 - N°20170260534

The object of the invention is to provide an anaerobic enterobacterium having a higher therapeutic effect on an anaerobic site such as a solid tumor tissue and an ischemic disease site. A bacterium of the genus bifidobacterium, which is transformed with a plasmid co-expressing two types of heterologous polypeptides and comprising two types of secretory expression cassettes each sequentially comprising ...
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Polypeptide Patent Applications
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Recombinase-mediated integration of a polynucleotide library
Novozymes A/s
September 14, 2017 - N°20170260520

The present invention provides methods for integrating a polynucleotide library of interest in the chromosome of a filamentous fungal host cell using a site-specific recombinase, polynucleotide library expression systems comprising a host cell and a polynucleotide construct, as well as the resulting filamentous fungal host cells comprising a polynucleotide library and their cultivation to produce a polypeptide.
Sortase-modified molecules and uses thereof
Research Development Foundation
September 14, 2017 - N°20170260517

Cell-targeted cytotoxic agents, including sortase serine protease constructs, are provided. Such compounds can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e. G., cancer). In some aspects, recombinant sortase serine proteases, such as granzyme b polypeptides, are provided that exhibit improved stability and cell toxicity.
Optimized factor ix gene
Biogen Ma Inc.
September 14, 2017 - N°20170260516

The present invention provides codon optimized factor ix sequences, vectors and host cells comprising codon optimized factor ix sequences, polypeptides encoded by codon optimized factor ix sequences, and methods of producing such polypeptides. The present invention also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized factor ix nucleic acid sequence or ...
Method for producing variants having an fc with improved sialylation
Laboratoire Francais Du Fractiionnement Et Des Biotechnologies
September 14, 2017 - N°20170260254

The present invention relates to a method for increasing the sialylation of an fc fragment, including a mutation step of at least one amino acid selected from among the amino acids in positions 240 to 243, 258 to 267 and 290 to 305 of the fc fragment, the numbering being that of the eu index or equivalent in kabat. The present invention also relates to a ...
Ecotin variants
Ansun Biopharma, Inc.
September 14, 2017 - N°20170260251

Ecotin variants and their use in treating viral hemorrhagic fever are described. Described herein are methods for treating systemic inflammatory response syndrome or viral hemorrahagic fever by administering an ecotin polypeptide. Described herein is a polypeptide comprising the amino acid sequence of any of seq id nos: 2-9 and 11-18. Also described: is a polypeptide comprising the amino acid sequence ...
Stabilized insulinotropic peptides and methods of use
Dana-farber Cancer Institute, Inc.
September 14, 2017 - N°20170260248

The present invention provides stably crosslinked insulinotropic polypeptides having superior and unexpected benefits in the treatment of conditions involving abnormal glucose homeostasis, e. G., type 2 diabetes and conditions relating to type 2 diabetes. Such benefits include, but are not limited to, extended polypeptide half-life, enhanced alpha-helicity, improved thermal stability and protease resistance, increased functional activity and pharmacologic properties, improved bioavailability when ...
Endoplasmic reticulum localization signals
Intrexon Corporation
September 14, 2017 - N°20170260244

The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or multimeric form. The localization signals are utilized as research tools or are linked to therapeutics. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other macromolecules to ...
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Polypeptide Patent Applications
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Method for modifying rna binding protien using ppr motif
Kyushu University, National University Corporation
September 14, 2017 - N°20170260242

The objects of the present invention are to identify the amino acids that play a principal role for the ppr motif to act as a rna binding unit, as well as to provide a technology that regulates the rna binding property thereof. The present invention provides a method for altering the rna binding property of a ppr protein having one ...
New polypeptides
Affibody Ab
September 14, 2017 - N°20170260238

The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal fc receptor fcrn, and provides an fcrn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein said first and second monomer unit search comprises an fcrn binding motif. Said fcrn binding dimer binds fcrn with higher ...
Polypeptide expressed in the stratum corneum and use thereof
Universite Paul Sabatier Toulouse Iii
September 14, 2017 - N°20170260235

Polypeptides belonging to the family of late proteins of the cornified envelope (lce), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and ...
Modified amino acids
Sutro Biopharma, Inc.
September 14, 2017 - N°20170260137

Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.
Novel pd-l1 binding polypeptides for imaging
Bristol-myers Squibb Company
September 14, 2017 - N°20170258948

Provided herein are novel 10fn3 domains which specifically bind to pd-l1, as well as imaging agents based on the same for diagnostics.
Versikine for inducing and potentiating an immune response
Wisconsin Alumni Research Foundation
September 14, 2017 - N°20170258898

Disclosed are methods, kits, polypeptides, and pharmaceutical compositions for inducing an immune response in a subject, which may include a t-cell mediated immune response. The methods comprise administering to the subject, or to explanted cells of the subject, a pharmaceutical composition comprising an effective amount of versikine or a variant of versikine that induces the t-cell mediated immune response. The ...
Compositions and methods to treat aids
University Of Massachusetts
September 14, 2017 - N°20170258892

Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against hiv are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different hiv envelope glycoproteins. The synthetic, codon-optimized dnas encoding one or more hiv proteins are a combination of different nucleic acids, such as dna plasmids, ...
Fgf-8 for use in treating diseases or disorders of energy homeostasis
Technische Universität München
September 14, 2017 - N°20170258874

The present invention relates to polypeptides for use in treating diseases or disorders of energy homeostasis such as obesity, dyslipidemia, diabetes, insulin resistance, hyperglycemia or the metabolic syndrome. The invention also relates to polynucleotides encoding said polypeptides for use in treating diseases or disorders of energy homeostasis. Also provided by the present invention are pharmaceutical compositions comprising said polypeptides and ...
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