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Polypeptide

Polypeptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods for mass spectrometry of mixtures of protein or polypeptides using proton transfer reaction
Thermo Finnigan Llc
April 12, 2018 - N°20180102243

A method comprises: (1) making an extract of a biological sample; (2) repeatedly: (a) choosing a respective one of a plurality of pre-determined protein or polypeptide analyte compounds; (b) introducing a portion of the extract into an electrospray ionization source, thereby generating positive ions comprising a plurality of ion species; (c) isolating a plurality of subsets of the ion species comprising respective ...
Dna methylation markers for metastatic prostate cancer
The Johns Hopkins University
April 12, 2018 - N°20180100196

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (tm) and allele-specific methylation (asm) alternation, this method, ...
Nucleic acid construct
Ucl Business Plc
April 12, 2018 - N°20180100163

The present invention provides a nucleic acid construct comprising the following structure: a-x-b in which a and b are nucleic acid sequences encoding a first and a second polypeptide of interest (poi); and x is a nucleic acid sequence which encodes a cleavage site, wherein either the first or second poi is a transmembrane protein which comprises an intracellular retention ...
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S. pyogenes cas9 mutant genes and polypeptides encoded by same
Integrated Dna Technologies, Inc.
April 12, 2018 - N°20180100148

This invention pertains to mutant cas9 nucleic acids and proteins for use in crispr/cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant cas9 protein, wherein the isolated mutant cas9 protein is active in a crispr/cas endonuclease system, wherein the crispr/cas endonuclease system displays reduced off-target editing activity and maintained ...
Prostate-specific membrane antigen binding proteins and related compositions and methods
Aptevo Research And Development Llc
April 12, 2018 - N°20180100021

The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (psma) and are useful for the treatment of prostate cancer (e. G., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (bph). In one embodiment, the multi-specific poly-peptide therapeutics bind both psma-expressing cells and the t-cell receptor complex on t cells to ...
Antibodies to il-6 and use thereof
Alderbio Holdings Llc
April 12, 2018 - N°20180100013

The present invention is directed to antibodies and fragments thereof having binding specificity for il-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the vh, vl and cdr polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-il-6 antibodies and binding fragments thereof conjugated ...
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Polypeptide Patent Applications
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Polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin a
Vhsquared Limited
April 12, 2018 - N°20180100009

There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin a.
Polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin b
Vhsquared Limited
April 12, 2018 - N°20180100008

There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin b.
Method for the expression of polypeptides using modified nucleic acids
Hoffmann-la Roche Inc.
April 12, 2018 - N°20180100006

Herein is reported a method for recombinantly producing a polypeptide in a cell comprising the step of cultivating a cell which comprises a nucleic acid encoding the polypeptide, and recovering the polypeptide from the cell or the cultivation medium, wherein each of the amino acid residues of the polypeptide is encoded by at least one codon, whereby the different codons ...
Bifunctional stapled polypeptides and uses thereof
President And Fellows Of Harvard College
April 12, 2018 - N°20180100001

The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e. G., proteins). Certain aspects relate to bifunctional stapled or stiched peptides that bind to an effector biomolecule through the effector domain and ...
Nucleic acid construct
Ucl Business Plc
April 12, 2018 - N°20180099994

The present invention provides a nucleic acid construct comprising the following structure: a-x—b in which a is nucleic acid sequence encoding a first polypeptide which comprises a first signal peptide; b is nucleic acid sequence encoding a second polypeptide which comprises a second signal peptide and x is a nucleic acid sequence which encodes a cleavage site, wherein ...
Therapeutic compositions and methods for treating hiv including identification and manipulation of particular domains associated ...
The Regents Of The University Of California
April 12, 2018 - N°20180099041

Selection of hiv vaccine antigens by use of intrapatient sequence variation to identify mutations in the hiv envelope glycoprotein that affect the binding of broadly neutralizing antibodies and polypeptides identified by these methods.
Novel mhc-independent tumor-associated antigens
Universitaet Duisburg-essen
April 12, 2018 - N°20180099033

The present invention relates to novel tumor-associated antigens, which elicit independently from a presentation via mhc a cd8-positive t-cell response. Gm-csf-receptor alpha chain (csf2ra) and tyrosinase-related protein 2 (trp-2) were found to be targets of cd8-positive t-cell clones which could detect the proteins on the surface of hla i negative melanoma cells. Thus, the invention provides proteins, protein ...
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Polypeptide Patent Applications
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Activation of bioluminescence by structural complementation
Promega Corporation
April 05, 2018 - N°20180095074

Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e. G., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
Production of fragrant compounds
Firmenich Sa
April 05, 2018 - N°20180094281

Provided herein is an isolated polypeptide from juniperus virginiana, platycladus orientalis ‘beverleyensis’ or platycladus orientalis comprising a (+)-cedrol or a (−)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from juniperus virginiana, platycladus orientalis ‘beverleyensis’ or platycladus orientalis encoding a (+)-cedrol or (−)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol ...
Eukaryotic expression vectors comprising regulatory elements of the globin gene clusters
Glycotope Gmbh
April 05, 2018 - N°20180094279

The present invention pertains to the field of recombinant protein production. Novel expression cassettes comprising elements of the human globin gene clusters are provided which show enhanced expression rates of proteins or polypeptides of interest.
Protein screening methods
X-body, Inc.
April 05, 2018 - N°20180094256

The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
Xylanases for solubilising arabinoxylan-containing material
Dupont Nutrition Biosciences Aps
April 05, 2018 - N°20180094253

The present invention relates to a method for solubilising arabinoxylan-containing material (particularly insoluble arabinoxylan-containing material), comprising admixing a xylan-containing material with a xylanase comprising a polypeptide sequence shown herein as seq id no. 3, seq id no. 2, seq id no. 1, seq id no. 9, seq id no. 10, seq id no. 11 or seq id no. 15, or a variant, homologue, fragment or derivative thereof ...
Polymerase variants
Roche Molecular Systems, Inc.
April 05, 2018 - N°20180094249

The present disclosure provides variant pol6 polymerase polypeptides, compositions comprising the pol6 variant polypeptides, and methods for using the variant pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental pol6 polypeptides ...
Antibodies directed against interleukin 36 receptor (il-36r)
Anaptysbio, Inc.
April 05, 2018 - N°20180094065

The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the interleukin 36 receptor (il-36r). The invention provides an il-36r-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using ...
Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof
Biontech Ag
April 05, 2018 - N°20180094059

The present invention relates to a polypeptide comprising a component a with at least three tumor necrosis factor (tnf) homology domains of tnf-ligand family members (thd) in which c-terminal and n-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional c-terminal and/or n-terminal amino acids of the thd or variants thereof, and ...
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