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Polypeptide

Polypeptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and kits for detecting protein-protein interactions
UniversitÉ Paul Sabatier Toulouse Iii
June 14, 2018 - N°20180164324

The present invention relates to methods and kits for detection protein-protein interactions. In particular, the present invention relates to a method for detecting the binding between a first polypeptide (a) and a second polypeptide (b) in a cell comprising i) providing a cell that expresses (a) a polypeptide (gfp1-9) comprising an amino acid sequence having at least 90% of identity ...
Alkaline pretreatment of parvoviruses for immunoassays
Roche Diagnostics Operations, Inc.
June 14, 2018 - N°20180164314

Disclosed is a method for detecting a capsid polypeptide of a non-enveloped virus in a sample from a subject which includes (a) contacting the sample with a base, and (b) detecting a capsid polypeptide of the virus in the sample. Moreover, the present disclosure relates to a method for pre-processing a sample from a subject for detection of a virus, ...
Glycosyl hydrolase enzymes and uses thereof for biomass hydrolysis
Danisco Us Inc
June 14, 2018 - N°20180163242

The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having glycosyl hydrolase (gh) family 61/endoglucanase activity and/or a β-glucosidase polypeptide, methods for hydrolyzing biomass material, and methods for using such compositions.. .
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Membrane-penetrating peptides to enhance transfection and compositions and methods for using same
Life Technologies Corporation
June 14, 2018 - N°20180163231

The present invention is directed to non-naturally occurring peptides containing a membrane-penetrating amino acid sequence and further at least one polycationic moiety or peptide sequence. The peptides are suitable for use in delivery a cargo to the interior of a cell.
Novel recombinant adeno-associated virus capsids containing a designed ankyrin repeat protein (darpin) or fragment thereof
The Board Of Trustees Of The Leland Stanford Junior University
June 14, 2018 - N°20180163229

The present invention relates to variant aav capsid polypeptides containing designed ankyrin repeat proteins (darpins), wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction, and/or tropism in human liver and/or hepatocyte cells, or human pancreas and/or pancreatic cells, as compared to capsid polypeptides that do not include darpins.. .
Expression cassette
Glenmark Pharmaceuticals S.a.
June 14, 2018 - N°20180163225

The present invention relates to an expression cassette useful for the expression of a polynucleotide sequence encoding a polypeptide.. .
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Synthetic pathway for biological carbon dioxide sequestration
North Carolina State University
June 14, 2018 - N°20180163220

This invention relates to methods for increasing carbon fixation and/or increasing biomass production in a plant, comprising: introducing into a plant, plant part, and/or plant cell heterologous polynucleotides encoding (1) a succinyl coa synthetase, (2) a 2-oxoglutarate:ferredoxin oxidoreductase, (3) a 2-oxoglutarate carboxylase, (4) an oxalosuccinate reductase, or (5) an isocitrate lyase, or (6) a succinyl coa synthetase and a 2-oxoglutarate:ferredoxin oxidoreductase, (7) a 2...
Crispr/cas9 based engineering of actinomycetal genomes
Danmarks Tekniske Universitet
June 14, 2018 - N°20180163196

The present invention relates to crispr/cas-based methods for generating random-sized deletions around at least one target nucleic acid sequence, or for generating precise indels around at least one target nucleic acid sequence, or for modulating transcription of at least one target nucleic acid sequence. Also disclosed is a clonal library comprising clones with random-sized deletions, as well as polynucleotides, ...
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
Novozymes, Inc.
June 14, 2018 - N°20180163192

The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Polypeptide variants
Novozymes A/s
June 14, 2018 - N°20180163189

The present invention relates to polypeptide variants and methods for obtaining variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Alk4:actriib heteromultimers and uses thereof
Acceleron Pharma Inc.
June 14, 2018 - N°20180163187

In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an alk4 receptor and an extracellular domain of actriib. In certain aspects, such soluble alk4:actriib complexes may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumors, and/or cancerous cells.
Method of enhancing somatic cell reprogramming with the acetyllysine reader brd3r
The Uab Research Foundation Inc.
June 14, 2018 - N°20180163180

A method of generating an induced pluripotent stem cell (ipsc) comprises introducing to an animal somatic cell at least one nuclear reprogramming inducing factor and a brd3r polypeptide or at least one nucleic acid expressing the at least one nuclear reprogramming factor and the brd3r-related polypeptide in the recipient somatic cell, and culturing said cell to generate an ...
Assembly of bispecific antibodies
Genentech, Inc.
June 14, 2018 - N°20180162955

Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule.
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Inhibitors of type 2 vascular endothelial growth factor receptors
Bristol-myers Squibb Company
June 14, 2018 - N°20180162926

The present disclosure relates to novel vascular endothelial growth factor receptor (vegfr)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (vegfs). The present disclosure also provides various improvements relating to single domain binding polypeptides..
Albumin variants
Albumedix A/s
June 14, 2018 - N°20180162925

The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin..
Fusion polypeptides capable of activating receptors
Regeneron Pharmaceuticals, Inc.
June 14, 2018 - N°20180162924

A fusion polypeptide comprising (a)x-m-(a′)y, wherein a and a′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor.
Il-37 variants
Hudson Institute Of Medical Research
June 14, 2018 - N°20180162918

This invention relates to polypeptides, including variants of interleukin-37 (il-37), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions.
Methods and compositions for modifying plant architecture and development
Pioneer Hi-bred International, Inc.
June 14, 2018 - N°20180162915

Methods and compositions useful for modifying plant architecture and development are provided herein. Plants with altered levels of mate-efflux polypeptides that exhibit altered agronomic characteristics are provided.
Polypeptides for the diagnosis and the treatment of c3 nef associated c3 glomerulopathy
Assistance Publique-hÔpitaux De Paris (aphp)
June 14, 2018 - N°20180162911

The present invention relates to polypeptides for the diagnosis and treatment of c3 nef associated c3 glomerulopathy. In particular, the present invention is defined by the claims.
De novo structural protein design for manufacturing high strength materials
The Penn State Research Foundation
June 14, 2018 - N°20180162910

Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites comprising stacks of one or more β-sheets and the amorphous subsequences form a network of hydrogen bonds.
Conotoxin peptide k-cptx-btl03, preparation method therefor, and uses thereof
Bgi Shenzhen
June 14, 2018 - N°20180162909

Provided are a conotoxin peptide κ-cptx-bt103 and a derivative polypeptide. The amino acid sequence of the conotoxin peptide is indicated by seq id no: 1.
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