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Polypeptide patents



      
           
This page is updated frequently with new Polypeptide-related patent applications. Subscribe to the Polypeptide RSS feed to automatically get the update: related Polypeptide RSS feeds. RSS updates for this page: Polypeptide RSS RSS


Date/App# patent app List of recent Polypeptide-related patents
08/28/14
20140245499
 Sorghum plants having a mutant polynucleotide encoding the large subunit of mutated acetohydroxyacid synthase protein and increased resistance to herbicides patent thumbnailnew patent Sorghum plants having a mutant polynucleotide encoding the large subunit of mutated acetohydroxyacid synthase protein and increased resistance to herbicides
A sorghum seed comprising in its genome at least one polynucleotide encoding a polypeptide having an alanine to threonine substitution at position 93 of the sorghum ahas protein large subunit. The plant has increased resistance to one or more herbicides, for example from the imidazolinone group, as compared to wild-type sorghum plants.
08/28/14
20140245498
 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/28/14
20140245497
 Drought tolerant plants and related constructs and methods involving genes encoding ferredoxin family proteins patent thumbnailnew patent Drought tolerant plants and related constructs and methods involving genes encoding ferredoxin family proteins
Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferredoxin family protein..
08/28/14
20140245496
 Compositions and methods for the biosynthesis of vanillan or vanillin beta-d-glucoside patent thumbnailnew patent Compositions and methods for the biosynthesis of vanillan or vanillin beta-d-glucoside
Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant arom polypeptide and/or mutant catechol-o-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or udp-glycosyltransferases (ugts). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-d-glucoside..
08/28/14
20140245491
 Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use patent thumbnailnew patent Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
08/28/14
20140245490
 Fertilization and fruit size patent thumbnailnew patent Fertilization and fruit size
Plants having modulated expression of a haf or bee polypeptide and which modulate aspects of plant fertility, such as parthenocarpy, fertilization efficiency, and/or fruit size, are described. Methods of modulating fertility characteristics in a plant by modulating the expression of a haf or bee polypeptide in the plant are also described..
08/28/14
20140245474
 Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold patent thumbnailnew patent Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold
Methods and materials for modulating cold tolerance levels in plants are disclosed. For example, nucleic acids encoding cold tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells.
08/28/14
20140245467
 Genetically modified major histocompatibility complex mice patent thumbnailnew patent Genetically modified major histocompatibility complex mice
The invention provides genetically modified non-human animals that express chimeric human/non-human mhc i and mhc ii polypeptides and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same.
08/28/14
20140245466
 Humanized t cell co-receptor mice patent thumbnailnew patent Humanized t cell co-receptor mice
The invention provides genetically modified non-human animals that express chimeric human/non-human t cell co-receptor polypeptides (e.g., cd4, cd8α, cd8β), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same..
08/28/14
20140243504
 Antibodies comprising chimeric constant domains patent thumbnailnew patent Antibodies comprising chimeric constant domains
Antibodies, antigen-binding proteins and fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric fc-containing antibodies, antigen-binding proteins and fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric fc-containing proteins are provided..
08/28/14
20140243503
new patent Fgf21 mutants and uses thereof
The invention provides nucleic acid molecules encoding fgf21 mutant polypeptides, fgf21 mutant polypeptides, pharmaceutical compositions comprising fgf21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.. .
08/28/14
20140243203
new patent Gene switch compositions and methods of use
Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound.
08/28/14
20140242660
new patent Chimeric isoprenoid synthases and uses thereof
Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide..
08/28/14
20140242637
new patent Artificial introns
The invention concerns the field of recombinant gene engineering. It concerns novel artificial introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel artificial intron sequences..
08/28/14
20140242607
new patent Antibody for detecting epithelial ovarian cancer marker and method for diagnosing epithelial ovarian cancer
It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-β1,6-n-acetylglucosaminyltransferase 5b antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase β1,6-n-acetylglucosaminyltransferase 5b as an epithelial ovarian cancer marker.
08/28/14
20140242249
new patent Polypeptide having phytase activity and increased temperature resistance of the enzyme activity, and nucleotide sequence coding said polypeptide
The invention relates to a recombinant dna molecule encoding a polypeptide having phytase activity and increased temperature stability and increased proteolytic stability of the enzyme activity. The dna sequence has been obtained by variation of the mature wild-type e.
08/28/14
20140242152
new patent Immunogenic compositions and uses thereof
This invention generally relates to immunogenic compositions that comprise an rna component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in rna-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen.
08/28/14
20140242116
new patent Spray dried compositions and methods of use
Provided herein are insoluble particles that include polypeptides. The polypeptides may have immunogenicity that is greater than the immunogenicity of the same polypeptides when they are not present in the particle.
08/28/14
20140242102
new patent Influenza hemagglutinin and neuraminidase variants
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.. .
08/28/14
20140242075
new patent Antibody variants and uses thereof
Described herein are polypeptides and related antibodies comprising a variant fc domain. The variant fc domain provide for stabilized fc:fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as cdc-response..
08/21/14
20140237687
Plants having enhanced yield-related traits and a method for making the same
The present invention provides a method for enhancing various economically important yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a patl (patellin) polypeptide, a prp38 (precursor rna processing factor 38) polypeptide, an ada2 (adaptor 2) polypeptide, a gata-like polypeptide, or a wd40 repeat (wdr) 23-like polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a patl polypeptide, a prp38 polypeptide, an ada2 polypeptide, a gata-like polypeptide, or a wdr23-like polypeptide, which plants have improved yield-related traits relative to corresponding wild type plants or other control plants.
08/21/14
20140236497
Methods and systems for experimental set-up and data analysis in targeted proteomics applications
The invention relates to the analysis of compounds with mass spectrometry and more particularly to instruments, substances, and methods for polypeptide analysis, in particular in targeted proteomics applications and based on indexed retention time as peptide specific property. The method of chemical analysis comprises the steps of: a) providing a first complex sample comprising a set of at least two reference peptides associated to an indexed retention time scale (irt), as well as at least one further peptide; b) performing lc-ms on said complex sample and determining the empirical retention time values (rte) of the reference peptides and of the at least one further peptide; c) translating the empirical retention time values (rte) of the reference peptides and of the at least one further peptide into the indexed retention time scale and associating to each reference peptide a reference indexed retention time value (irtr) and to the at least one further peptide an associated indexed retention time value (irta); d) providing a second complex sample comprising at least one polypeptide as well as said set of the at least two reference peptides; e) performing lc-ms on said second complex sample and determining the empirical retention time values (rte) of the reference peptides; f) translating the empirical retention time values (rte) of the reference peptides into the indexed retention time scale by numerically adapting the transformation function for the conversion of the retention time values (rte) into indexed retention time values such that the calculated indexed retention time values (irte) calculated based on the measured retention time values (rte) of the reference peptides match the assigned indexed retention time values (irtr) of the reference peptides; g) determining the predicted empirical retention time value (rtp) of the at least one further peptide by using the numerically adapted transformation function determined in step f)..
08/21/14
20140235832
Rank ligand polypeptides
Described herein are kits for use in detecting rankl polypeptides.. .
08/21/14
20140235823
Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein.
08/21/14
20140235553
Compositions and methods for introduction of macromolecules into cells
Disclosed are novel compositions and methods for introduction of macromolecules and nanoparticles into living cells. The invention includes a polypeptide sequence which when fused to a macromolecule or nanoparticle enhances its introduction into the cell..
08/21/14
20140235549
Stabilized polypeptides as regulators of rab gtpase function
The present invention provides inventive polypeptides comprising a c terminal rab binding domain (rabbd) of rab family interacting proteins (fips) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating rab function comprising contacting an inventive stapled polypeptide with a rab protein, and methods of treatment associated with modulation of rab activity.
08/21/14
20140235538
Stabilized insulin-like growth factor polypeptides
The invention relates to stabilized polypeptides having an igf-1 or igf-2 sequence and an e-peptide sequence, where the natural physiological cleavage of the e-peptide from the igf is prevented.. .
08/21/14
20140235535
Engineered polypeptides having enhanced duration of action with reduced immunogenicity
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration, and reduced immunogenicity. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides.
08/21/14
20140235499
Assay for inhibitors of cip/kip protein degradation
An assay and system compatible with high throughput screening (hts) that is capable of identifying inhibitors, such as small-molecule inhibitors, of the degradation of the cdk inhibitor p21, are described. The assay is based on the use of fusion protein comprising (i) a p2 polypeptide; and (i) a reporter protein linked to the c-terminal of said p21 polypeptide, wherein the fusion protein has a half-life that is similar to that of the p21 polypeptide.
08/21/14
20140235482
Immunoglobulin fc polypeptides
Methods and compositions involving polypeptides having an aglycosylated antibody fc domain. In certain embodiments, polypeptides have an aglycosylated fc domain that contains one or more substitutions compared to a native fc domain.
08/21/14
20140235467
Protease-resistant systems for polypeptide display and methods of making and using thereof
The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.. .
08/21/14
20140234976
Compositions and methods for conferring herbicide resistance
The present invention provides a protein, specifically parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism.
08/21/14
20140234969
Methods for enhancing genome stability and telomere elongation in embryonic stem cells
The disclosure provides methods for increasing genome stability of an embryonic stem (es) cell or induced pluripotent stem (ips) cell, increasing telomere length in an es or ips cell, or both, for example by contacting an es or ips cell with an agent that increases expression of zscan4 in the cell. Methods for increasing genome stability or increasing telomere length in a population of es or ips cells are provided, for example by selecting zscan4+ es or ips cells from the population of es or ips cells (which can include both zscan4+ and zscan4− es or ips cells).
08/21/14
20140234962
Ligands modified by circular permutation as agonists and antagonists
The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof..
08/21/14
20140234943
Viruses lacking epithelial cell receptor entry
The document provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The document also provides methods for using viruses to treat cancer patients.
08/21/14
20140234924
Variants of glycerol dehydrogenase having d-lactate dehydrogenase activity and uses thereof
The present invention provides methods of designing and generating glycerol dehydrogenase (glydh) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding glydh polypeptide variants having altered function as compared to the parent polypeptide.
08/21/14
20140234921
Novel cutinases, their production and uses
The present invention relates to novel polypeptides, or fragments of polypeptides, genes encoding them and means for producing said polypeptides. In detail the invention relates to polypeptides having esterase, suberinase and/or cutinase activity at low ph.
08/21/14
20140234918
Polypeptides having peroxygenase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/21/14
20140234907
Polypeptides having endoglucanase activity and polynucleotides encoding same
Provided are isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/21/14
20140234903
Biosynthetic gene cluster for the production of peptide/protein analogues
A novel gene cluster encoding polypeptides involved in the generation of bio synthetically unique peptide-based compounds is described. In addition, new methods for biosynthetic engineering and production of modified peptides and proteins are disclosed.
08/21/14
20140234898
Protein and peptide libraries
Provided herein are, inter alia, methods for linking an mrna molecule to a polypeptide (e.g., a peptide or a protein) by linking the mrna molecule to a linking amino acid in the polypeptide, or by linking the mrna molecule to a linking trna to which the polypeptide is attached, via reactions not catalyzed by the ribosome, and methods for making polypeptide libraries. Also provided are mrna-protein complexes and mrna-trna-protein complexes, libraries containing these complexes, and methods of using these complexes..
08/21/14
20140234897
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Disclosed are isolated polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. Furthermore, nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains are disclosed..
08/21/14
20140234893
Heterologous intron within an immunoglobulin domain
The invention concerns the field of recombinant gene engineering. It concerns novel introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes with heterologous introns, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel intron sequences as heterologous introns..
08/21/14
20140234841
Compositions, methods and kits to detect dicer gene mutations
In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a dicer1 polypeptide.. .
08/21/14
20140234533
Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
08/21/14
20140234375
Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
Provided herein are cells, vectors and viruses in association with a mutant polypeptide that has emerged in response to a therapeutic or prophylactic agent; compositions comprising such cells, vectors and viruses and methods for their use in eliciting an immune response to the mutant polypeptide. In some examples, the immune response is a cellular immune response..
08/21/14
20140234365
2-hydroxyhippuric acid analogs, and methods for their synthesis and use
The present invention relates to novel 2-hydroxyhippuric acid analogs, and methods for their synthesis and use. Such analogs are designed to provide a protected or functional moiety such as a free thiol (—sh) group or a protected thiol group, thereby providing a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label..
08/21/14
20140234363
Polypeptides from non-typeable haemophilus influenzae
Polypeptides comprising non-typeable haemophilus influenzae (nthi) amino acid sequences. Over 2500 specific nthi proteins are disclosed.
08/21/14
20140234352
B7-h3 and b7-h4, novel immunoregulatory molecules
The invention provides novel b7-h3 and b7-h4 polypeptides useful for co-stimulating t cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides..
08/21/14
20140234332
Novel hiv-2 isolate
The invention provides a novel strain of hiv-2 capable of causing immunodeficiency. The invention also provides compositions comprising the nucleic acids and polypeptides characteristic of this hiv-2 virus, antibodies specific for this hiv-2 virus, methods of using these compositions, and methods of detecting hiv-2 virus..
08/21/14
20140234313
Soluble polypeptides
The invention relates generally to polypeptides, such as antibody molecules, that demonstrate high stability and solubility. In particular, the invention relates to polypeptides comprising paired vl and vh domains that demonstrate soluble expression and folding in a reducing or intracellular environment.
08/21/14
20140234311
Albumin variants
The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin..
08/21/14
20140234290
Modified factor x polypeptides and uses thereof
Modified therapeutic proteins are provided. In particular modified factor x polypeptides, which includes the factor x zymogen, factor xa and other forms of factor x, and uses thereof are provided..
08/21/14
20140234288
Lysosomal acid lipase therapy for nafld and related diseases
The present invention comprises methods and compositions for the treatment or alleviation of nafld (non-alcoholic fatty liver disease) and those conditions associated with nafld, including fatty liver disease, nonalcoholic steatohepatitis (nash) and cirrhosis through the use of pharmaceutical formulations of lysosomal acid lipase or related proteins and/or polypeptides. This invention is also directed to a combination therapy treatment for treating the metabolic syndrome.
08/14/14
20140230098
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230097
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230096
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230094
Yield increase in plants overexpressing the shsrp genes
A transgenic crop plant transformed by a serine hydroxymethyltransferase-like stress-related polypeptide (shsrp) coding nucleic acid, wherein expression of the nucleic acid sequence in the crop plant results in the plant's increased root growth, and/or increased yield, and/or increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic crop plants.
08/14/14
20140230081
Polynucleotide, polypeptide, animal model and method for the development of complement system modulators
The present invention is in the field of molecular biology, more particularly, the present invention relates to nucleic acid sequences and amino acid sequences of a hamster c5ar1 and the use of hamster as an animal model for the characterization of complement system modulators within drug discovery.. .
08/14/14
20140228548
Viral clearance methods
The invention provides methods for separating a polypeptide of interest (such as an antibody) from a virus. In some embodiments, the methods involve eluting the polypeptide of interest from a protein a resin with an elution buffer have a particular range of conductivity values that minimizes the amount of virus that co-elutes with the polypeptide of interest..
08/14/14
20140228546
Serum albumin binding proteins
The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.. .
08/14/14
20140228544
Constructs and libraries comprising antibody surrogate light chain sequences
The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising vpreb sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same..
08/14/14
20140228540
Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
The present invention relates to timp-3 binding compositions, methods of producing such compositions, and methods of using such compositions, including in the treatment of various conditions.. .
08/14/14
20140228294
Natriuretic polypeptides with unique pharmacologic profiles
This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity.
08/14/14
20140228288
Pharmaceutical compositions
The present invention provides pharmaceutical compositions comprising at least one polypeptide having glp-1 activity wherein an effective dose of said pharmaceutical composition comprises 15 mg, 30 mg, 50 mg or 100 mg of said polypeptide having glp-1 activity. Also provided are methods of administering the pharmaceutical compositions of the invention..
08/14/14
20140228284
Pharmaceutical compositions
The present invention provides pharmaceutical compositions comprising at least one polypeptide having glp-1 activity wherein an effective dose of said pharmaceutical composition comprises 15 mg, 30 mg, 50 mg or 100 mg of said polypeptide having glp-1 activity. Also provided are methods of administering the pharmaceutical compositions of the invention..
08/14/14
20140228238
Genes and polypeptides relating to breast cancers
The present application provides novel human genes a7322, whose expression is markedly elevated in breast cancer. The present application also provides human genes f3374 whose expression is markedly elevated in breast cancer.
08/14/14
20140227799
Method for measuring anti-wt1 antibody
Provided is an invention relating to a method for measuring an anti-wt1 antibody in a sample allowing measurement and evaluation of the anti-wt1 antibody with higher accuracy and to use of the method. The method for measuring an anti-wt1 antibody in a sample includes using a polypeptide having antigenicity to the anti-wt1 antibody selected from a polypeptide comprising the amino acid sequence of positions 294-449 in seq id no: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides and/or a polypeptide having antigenicity to the anti-wt1 antibody selected from a polypeptide comprising the amino acid sequence of positions 181-324 in seq id no: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides..
08/14/14
20140227788
Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering metabolism in a cell using isolated and/or purified polypeptides and nucleic acid sequences from alicyclobacillus acidocaldarius..
08/14/14
20140227765
Compositions and methods related to viruses of the genus negevirus
Certain embodiments are directed to negevirus and their polynucleotides and polypeptides.. .
08/14/14
20140227763
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227761
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227760
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227759
Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use
An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The ogluc variant polypeptide has at least 60% amino acid sequence identity to seq id no: 1 and at least one amino acid substitution at a position corresponding to an amino acid in seq id no: 1.
08/14/14
20140227739
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227738
Polypeptides having protease activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227727
Unconventional protein secretion
The present invention relates to an expression cassette comprising a nucleotide sequence encoding an amino acid sequence, a fragment or variant thereof which directs unconventional protein secretion and a nucleotide sequence encoding a protein of interest. Also contemplated is a vector which comprises the expression cassette, host cells comprising the vectors as well as methods and uses for the production of a polypeptide of interest..
08/14/14
20140227708
Methods and kits used in identifying microrna targets
Described herein are methods and kits used to identify an endogenously expressed target mrna of a microrna of interest. The method involves the use of a dominant negative gw182 polypeptide that forms a stable complex with the target mrna.
08/14/14
20140227391
Polypeptides having alpha-glucosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
08/14/14
20140227346
Immunogenic combination compositions and uses thereof
This invention generally relates to immunogenic compositions that comprise an rna component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in rna-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens..
08/14/14
20140227313
Group a streptococcal m-related proteins and methods of use
Immunogenic group a streptococcus m-related polypeptides and peptides and immunogenic compositions comprising these m-related polypeptides and peptides are provided herein that evoke cross-opsonic and cross-protective anti-gas and anti-sdse antibodies in animals. Also provided are preparations comprising immunogenic compositions that comprise m-related polypeptides, peptides, or fusion proteins and that further comprise at least one additional group a streptococcus immunogen, such as an m peptide or spa peptide..
08/14/14
20140227312
A1 moiety of cholera toxin a subunit as an adjuvant for mucosal and systemic vaccines
The present invention relates to cholera toxin cta1 protein fragments, adjuvant compositions, and methods relating to adjuvants for vaccines. The invention also relates to using recombinant cta1 fragments conjugated to a polypeptide containing a protein transduction domain or cell-penetrating peptide as an immunomodulator..
08/14/14
20140227308
Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof
The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several hpv antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (cyaa) protein or of a fragment thereof, wherein said cyaa fragment retains the property of said adenylate cyclase protein to target antigen presenting cells. It also concerns polynucleotides encoding the same.
08/14/14
20140227306
Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
The present invention relates to use of multimeric multi-epitope peptide-based compositions for immunizing subjects against influenza by administering the compositions to the subject prior to or together with seasonal or pandemic influenza vaccines. The present invention also relates to compositions that include a multimeric multi-epitope polypeptide and a seasonal or pandemic preparation against influenza..
08/14/14
20140227305
Epstein-barr-virus vaccine
The present invention relates to a vaccine comprising a particle, said particle comprising (i) at least one epstein-barr virus (ebv) structural polypeptide, (ii) at least one ebv lytic polypeptide, (iii) membrane lipids, said particle being devoid of ebv dna, wherein (a) the b-cell transformation capacity of one or more ebv polypeptides required for b-cell transformation as comprised in said particle is disabled while their immunogenicity is maintained; and/or (b) said particle is devoid of one or more ebv polypeptides required for b-cell transformation. Furthermore, the invention relates to a method for generating a particle, to a cell obtained in the method of the invention, a kit comprising the vaccine or the particle generated according to the method of the invention.
08/14/14
20140227301
Immunogenic compositions against human progastrin peptides
Immunogens against human extended-progastrin species comprise (a) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a n- and/or c-terminal processed species of a progastrin joined to (ii) a 7 amino-acid spacer coupled to (b) an immunogenic carrier. Illustrative of the mimetic peptide/spacer combination are a 21 amino-acid peptide (seq id no.: 1) and other, related polypeptides (seq id nos.: 2-5).
08/14/14
20140227293
Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
The present invention provides methods and compositions for the treatment and prevention of angiogenesis, or cancer, e.g., metastatic cancer by administering an effective amount of an inhibitor of immunoglobulin containing proline rich receptor-1 (igpr-1) protein or expression. In particular, the present invention provides methods and compositions for the treatment and prevention of cancer by administering an effective amount of an inhibitor of immunoglobulin containing proline rich receptor-1 (igpr-1) protein or expression which is a soluble extracellular domain igpr-1.
08/14/14
20140227270
Bispecific anti-cxcr7 immunoglobulin single variable domains
The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting cxcr7 mediated tumour growth..
08/14/14
20140227267
Bovine fusion antibodies
Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (cdr3h) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the cdr3h.
08/14/14
20140227266
Nogo receptor antagonists
Disclosed are immunogenic nogo receptor-1 polypeptides, nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are nogo receptor antagonist polynucleotides.
08/14/14
20140227263
Use of fgfr1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in fgfr2
The present invention relates to the use of fibroblast growth factor receptor i (fgfr1) extracellular domain (ecd) polypeptides for treatment of cancers characterized by ligand dependent activating mutations in fibroblast growth factor receptor 2 (fgfr2). For example, the present invention relates to the treatment of endometrial cancers and other cancers wherein tumor cells express fgfr2 mutants in the igii-igiii hinge region or igiii domain of the protein, such as at amino acid positions 252 and/or 253..
08/14/14
20140227254
Antagonists of bmp9, bmp10, alk1 and other alk1 ligands, and uses thereof
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase i (alk1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of bmp9 and/or bmp10, ligands for alk1, may also be used to inhibit angiogenesis in vivo..


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