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Polypeptide

Polypeptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods for top-down multiplexed mass spectral analysis of mixtures of proteins or polypeptides
Thermo Finnigan Llc
July 20, 2017 - N°20170205425

Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (ptr) and real-time data analysis methods are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kda by removing charge and reducing the collisional cross section.
Mass spectrometry analysis of mutant polypeptides in biological samples
Cell Signaling Technology, Inc.
July 20, 2017 - N°20170205422

The invention relates to a method for determining the presence of at least one distinct polypeptide in a biological sample comprising contacting the biological sample with a hydrolyzing agent, wherein the hydrolyzing agent is capable of hydrolyzing the distinct polypeptide in a sequence-specific manner such that at least one distinct peptide having a predetermined peptide measured accurate mass would result ...
Polypeptides having glucoamylase activity and polynucleotides encoding same
Novozymes North America, Inc.
July 20, 2017 - N°20170204435

The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
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Methods of transforming a listeria
The Regents Of The University Of California
July 20, 2017 - N°20170204423

Site-specific listeria integration vectors and methods for their use are provided. The subject vectors include a bacteriophage integrase gene and a bacteriophage attachment site, where in many embodiments the bacteriophage that is the source 0 of these elements is a listeriophage. In certain embodiments, the subject vectors further include a multiple cloning site, where the multiple cloning site may further include ...
Dsrna for treating viral infection
Arrowhead Pharmaceuticals, Inc.
July 20, 2017 - N°20170204417

The invention relates to double-stranded ribonucleic acids (dsrnas) targeting gene expression of phosphatidylinositol 4-kinase (pi4k), in particular human phosphatidylinositol 4-kinase, catalytic, beta polypeptide (pik4cb) or human phosphatidylinositol 4-kinase, catalytic, alpha polypeptide (pik4ca), and their use for treating infection by positive stranded rna viruses such as hepatitis c virus (hcv). Each dsrna comprises an antisense strand having a ...
Polypeptides having protease activity and polynucleotides encoding same
Novozymes A/s
July 20, 2017 - N°20170204392

The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
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Thermus scotoductus nucleic acid polymerases
Applied Biosystems, Llc
July 20, 2017 - N°20170204385

The invention provides nucleic acids and polypeptides for a nucleic acid polymerase from a thermophilic organism, thermus scotoductus. The invention also provides methods for using these nucleic acids and polypeptides.
Isolated gdf trap polypeptide
Acceleron Pharma Inc.
July 20, 2017 - N°20170204382

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Biocatalysts for ezetimibe synthesis
Codexis Inc.
July 20, 2017 - N°20170204378

The present disclosure relates to non-naturally occurring polypeptides useful for preparing ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
Multispecific antibody constructs
Ucb Biopharma Sprl
July 20, 2017 - N°20170204200

The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (i): vh—ch1—x—v1; and b) a polypeptide chain of formula (ii): vl-cl-y—v2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors ...
Modified antigen binding polypeptide constructs and uses thereof
Zymeworks Inc.
July 20, 2017 - N°20170204199

The present invention provides heterodimer pairs that can comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain or fragment thereof. At least one of the heterodimers can comprise one or more amino acid modifications in the ch1 and/or cl domains, one or more amino ...
Zcytor17 heterodimeric cytokine receptor monoclonal antibodies
Zymogenetics, Inc.
July 20, 2017 - N°20170204190

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods ...
B7-h3 and b7-h4, novel immunoregulatory molecules
Mayo Foundation For Medical Education And Research
July 20, 2017 - N°20170204185

The invention provides novel b7-h3 and b7-h4 polypeptides useful for co-stimulating t cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.
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Polypeptide Patent Applications
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Chimeric polynucleotides
Moderna Therapeutics, Inc.
July 20, 2017 - N°20170204152

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules, which allow for customized placement, position and percent load of chemical modifications, which improve, alter or optimize certain physicochemical and pharmaceutical properties of the polynucleotides. In one non-limiting embodiment, such chimeric polynucleotides take the form or function as modified mrna molecules which ...
Polypeptides targeting vascular endothelial growth factor receptor and prostate specific membrane antigen
The Board Of Trustees Of The Leland Stanford Junior University
July 20, 2017 - N°20170204150

Polypeptides comprising a vegf scaffold modified to bind to psma are provided, and bifunctional derivatives thereof that also bind to vegfr. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment.
Hsa-gdf-15 fusion polypeptide and use thereof
Novartis Ag
July 20, 2017 - N°20170204149

The disclosure relates to fusion polypeptides comprising serum albumin or a functional variant thereof and gdf15 protein or a functional variant thereof and to pharmaceutical compositions that contain the fusion polypeptides, nucleic acids that encode the fusion polypeptides, methods of making the polypeptides and use of the polypeptides to decreasing appetite, decreasing body weight and treating metabolic diseases.
Anti-inflammatory properties of a surface protein of propionibacterium freudenreichii
Institut Pasteur De Lille (ipl)
July 20, 2017 - N°20170204145

Disclosed is a polypeptide including or consisting of the amino acid sequence seq id no:1, for use in the treatment or prevention of an inflammatory disease. It further encompasses a nucleic acid sequence encoding a polypeptide, a vector including a nucleic acid and a host cell including a nucleic acid sequence and/or a vector, for use in the treatment ...
Polypeptides for generating anti-influenza antibodies and uses thereof
Indian Institute Of Science
July 20, 2017 - N°20170204142

The present disclosure relates to a polypeptide comprising hemagglutinin stem domain fragments that can elicit broadly cross-reactive anti-influenza antibodies and confer protection against influenza virus. The disclosure also provides a method of preparing the polypeptide with biochemical and biophysical properties that enhance its immunogenic properties. Also provided are recombinant dna constructs, vectors, and host cells comprising the nucleic acid encoding ...
Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
Cytomx Therapeutics, Inc.
July 20, 2017 - N°20170204139

The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (upa), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and ...
Combination of lenalidomide and polypeptide construct, and uses thereof
Teva Pharmaceuticals Australia Pty Ltd
July 20, 2017 - N°20170202962

Methods for cancer treatment include administering to a cancer patient an anti-cd38 antibody-attenuated human ifn alpha-2b construct and lenalidomide or pomalidomide. Tumors that may be treated according to these methods include tumors which comprise cd-38 expressing tumor cells, including b-cell lymphoma, multiple myeloma, non-hodgkin's lymphoma, chronic myelogenous leukemia, chronic lymphocytic leukemia, and acute lymphocytic leukemia.
Highly immunogenic hiv p24 sequences
University Of Washington
July 20, 2017 - N°20170202950

The invention relates to peptides comprising part or all of a conserved element within a center-of-tree (cot) sequence derived from a family of polypeptides encoded by naturally occurring variants of hiv. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of hiv controller patients based on the detection ...
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