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Polypeptide

Polypeptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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High affinity vitamin d3 binding proteins
University Of Washington
November 09, 2017 - N°20170322229

The present disclosure provides isolated polypeptides with vitamin d3 binding activity and methods for their use as detection agents. In another aspect, the invention provides recombinant expression vector comprising an isolated nucleic acid of the invention operably linked to a control sequence. In another aspect, the invention provides recombinant host cells comprising the recombinant expression vector of the invention. In ...
Method and reagent for detecting ovarian clear cell adenocarcinoma
Tosoh Corporation
November 09, 2017 - N°20170322218

The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides nt-tfpi2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a ...
Glycosylation mutants for producing galactose-free and fucose-free polypeptides
Agency For Science, Technology And Research
November 09, 2017 - N°20170321240

We describe a method of reducing batch-to-batch variation or increasing homogeneity between batches in the production of a recombinantly expressed polypeptide. The method comprises expressing the polypeptide in a chinese hamster ovary (cho) cell comprising reduced udp-galactose transporter activity compared to a wild-type cho cell. In some embodiments, the cho cell further comprises reduced gdp-fucose transporter activity.
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Trispecific and/or trivalent binding proteins
Sanofi
November 09, 2017 - N°20170320967

The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable ...
Genetic products differentially expressed in tumors and the use thereof
Ganymed Pharmaceuticals Ag
November 09, 2017 - N°20170320963

The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association ...
Antibodies, variable domains & chains tailored for human use
Kymab Limited
November 09, 2017 - N°20170320936

The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, ...
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Methods of producing a zcytor17 heterodimeric cytokine receptor
Zymogenetics, Inc.
November 09, 2017 - N°20170320931

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods ...
Alpha/beta-polypeptide analogs of glucagon-like peptide 1
President And Fellows Of Harvard College
November 09, 2017 - N°20170320928

Described herein are peptide analogs of glucagon-like peptide 1 (glp-1) that retain agonist activity, but are more resistant to proteolytic degradation than native glp-1. In the analogs, at least one α-amino acid found in the native glp-1 is replaced with a β-amino acid residue, which may or may not be cyclically constrained. Pharmaceutical compositions containing the analogs ...
Il-22 polypeptides and il-22 fc fusion proteins and methods of use
Genentech, Inc.
November 09, 2017 - N°20170320926

The invention relates to il-22 polypeptides, il-22 fc fusion proteins and il-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to il-22 receptor associated reagents and methods of use thereof.
Mutated immunoglobulin-binding polypeptides
Ge Healthcare Bio-sciences Ab
November 09, 2017 - N°20170320922

The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a b or c domain of staphylococcus protein a (spa), as specified by seq id no 1 or seq id no 2, or of protein z, as specified by seq id no 3, wherein at least the glutamic acid residue at position 15 has been mutated to an amino ...
Protein m related immunoglobulin-binding polypeptides
The Scripps Research Institute
November 09, 2017 - N°20170320921

The invention relates to a group of isolated polypeptides and derivatives that can bind genetically to immunoglobulins or antibodies. The invention also relates to industrial and other applications of these molecules, e. G., antibody purifications.
Modified kappa light chain-binding polypeptides
Ge Healthcare Bioprocess R&d Ab
November 09, 2017 - N°20170320919

The invention discloses kappa light chain-binding polypeptide comprising a mutated binding domain of peptostreptococcus protein l, wherein at least one asparagine residue of a parental domain defined by, or having at least 95% or 98% sequence homology with, seq id no: 2-6 or 2 has been mutated to another amino acid residue which is not asparagine, proline or cysteine.
Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
The Texas A&m University System
November 09, 2017 - N°20170319671

Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided.
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High activity tumour inhibitor and preparation method and use thereof
Bao Kang Biomedical Healthcare Inc
November 09, 2017 - N°20170319648

Provided in the present invention are a yap protein inhibiting polypeptide and application thereof. In particular, the present invention obtains a key binding site of yap protein and tead, screens a polypeptide with best yap inhibitory activity and modifies the polypeptide, such as adding a disulfide linkage, replacing an amino acid, removing and/or adding (for example, adding a cell-penetrating ...
Compositions and methods for modifying a predetermined target nucleic acid sequence
Targetgene Biotechnologies Ltd.
November 09, 2017 - N°20170319613

Provided herein are compositions and methods for modifying a predetermined nucleic acid sequence. A programmable nucleoprotein molecular complex containing a polypeptide moiety and a specificity conferring nucleic acid (scna) which assembles in-vivo, in a target cell, and is capable of interacting with the predetermined target nucleic acid sequence is provided. The programmable nucleoprotein molecular complex is capable of specifically modifying ...
Methods of controlling fructan synthesis in plants
Commonwealth Scientific And Industrial Research Organisation
November 09, 2017 - N°20170318840

The present invention relates to plants with increased levels of water soluble carbohydrates, particularly fructan, in the stem and leaf sheath. The present invention also provides methods of identifying and/or producing these plants. In particular, the present invention relates to a novel class of polypeptides designated myb13 which upregulate the expression of enzymes involved in fructan synthesis. The present ...
Compositions and methods to control insect pests
E I Du Pont De Nemours And Company
November 09, 2017 - N°20170318814

Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a coleopteran plant pest or a diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of ...
Methods for the diagnosis or prognosis of breast cancer
E I Du Pont De Nemours And Company
November 02, 2017 - N°20170315125

Methods for detecting, diagnosing and monitoring an epithelial cancer in a patient are described comprising measuring in a sample from the patient ep-icd polypeptides and ep-icd polynucleotides. Methods for prognosis of breast cancer comprising measurement of nuclear ep-icd polypeptides and optionally epex polypeptides are provided. The invention also provides kits and compositions for carrying out the methods of the invention. ...
Novel luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
E I Du Pont De Nemours And Company
November 02, 2017 - N°20170314061

Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
Enzymatic one-pot reaction for double polypeptide conjugation in a single step
E I Du Pont De Nemours And Company
November 02, 2017 - N°20170314055

Herein is reported a method for producing an enzymatic conjugation product of three polypeptides comprising the simultaneous incubation of i) a first polypeptide comprising the amino acid sequence lpxtg (seq id no: 20, wherein x can be any amino acid residue), a second polypeptide comprising the amino acid sequence lpxta (seq id no: 31, wherein x can be any amino acid residue), ...
Adenovirus constructs and methods
E I Du Pont De Nemours And Company
November 02, 2017 - N°20170314044

This disclosure describes oncolytic adenovirus constructs and methods on using the constructs. Generally, the oncolytic constructs includes at least a partial deletion of e3, a heterologous polynucleotide encoding a heterologous polypeptide in place of the at least partial deletion of e3, and a cell-specific regulatory polynucleotide operationally linked to the heterologous polynucleotide.
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