|| List of recent Polyp-related patents
| Sorghum plants having a mutant polynucleotide encoding the large subunit of mutated acetohydroxyacid synthase protein and increased resistance to herbicides|
A sorghum seed comprising in its genome at least one polynucleotide encoding a polypeptide having an alanine to threonine substitution at position 93 of the sorghum ahas protein large subunit. The plant has increased resistance to one or more herbicides, for example from the imidazolinone group, as compared to wild-type sorghum plants.
| Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
| Drought tolerant plants and related constructs and methods involving genes encoding ferredoxin family proteins|
Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferredoxin family protein..
| Compositions and methods for the biosynthesis of vanillan or vanillin beta-d-glucoside|
Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant arom polypeptide and/or mutant catechol-o-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or udp-glycosyltransferases (ugts). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-d-glucoside..
| Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use|
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
| Fertilization and fruit size|
Plants having modulated expression of a haf or bee polypeptide and which modulate aspects of plant fertility, such as parthenocarpy, fertilization efficiency, and/or fruit size, are described. Methods of modulating fertility characteristics in a plant by modulating the expression of a haf or bee polypeptide in the plant are also described..
| Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold|
Methods and materials for modulating cold tolerance levels in plants are disclosed. For example, nucleic acids encoding cold tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells.
| Genetically modified major histocompatibility complex mice|
The invention provides genetically modified non-human animals that express chimeric human/non-human mhc i and mhc ii polypeptides and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same.
| Humanized t cell co-receptor mice|
The invention provides genetically modified non-human animals that express chimeric human/non-human t cell co-receptor polypeptides (e.g., cd4, cd8α, cd8β), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same..
| Phase-based operation of devices on a polyphase electric distribution system|
In one embodiment, a device in a computer network monitors an alternating-current (ac) waveform of an electrical power source at the device, where the power source is part of a polyphase power source system. Once the device determines a particular phase of the polyphase power source system at the device, then the device joins a directed acyclic graph (dag) specific to the particular phase.
| Antibodies comprising chimeric constant domains|
Antibodies, antigen-binding proteins and fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric fc-containing antibodies, antigen-binding proteins and fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric fc-containing proteins are provided..
| Fgf21 mutants and uses thereof|
The invention provides nucleic acid molecules encoding fgf21 mutant polypeptides, fgf21 mutant polypeptides, pharmaceutical compositions comprising fgf21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.. .
| Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid|
An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. An embodiment of said liquid preparation does not include any preservative.
| Gene switch compositions and methods of use|
Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound.
| Rf receiver with sideband symmetry circuit|
One aspect of the present invention includes an rf including a first mixer receiving an rf signal. A second mixer also receivers the rf signal.
| Chimeric isoprenoid synthases and uses thereof|
Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide..
| Hybrid organic-inorganic system for producing biofuels|
The present invention provides for a system for converting co2 and h2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more nucleic acids encoding genes for a recombinant surface display protein which is capable of tethering an electrocatalyst molecule, such as a cobalt(ii) complex supported by tetradentate polypyridyl ligand 2-bis(2-pyridyl)(methoxy)methyl-6-pyridylpyridine (py4), and enzymes for synthesizing a biologically derived compound, such as an alkane, alcohol, fatty acid, ester, or isoprenoid..
| Artificial introns|
The invention concerns the field of recombinant gene engineering. It concerns novel artificial introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel artificial intron sequences..
| Antibody for detecting epithelial ovarian cancer marker and method for diagnosing epithelial ovarian cancer|
It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-β1,6-n-acetylglucosaminyltransferase 5b antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase β1,6-n-acetylglucosaminyltransferase 5b as an epithelial ovarian cancer marker.
| Fiber-reinforced polypropylene resin composition and molded article thereof|
The present invention is to provide a fiber reinforced polypropylene resin composition which has low shrinkage, excellent grain transferability, flaw resistance and moulded appearance, can provide a moulded article having a smooth and soft tactile sensation on the surface thereof without foaming and has high rigidity, high impact strength and high heat resistance, as well as a method for producing the same and a moulded article thereof. These are implemented by a fiber reinforced polypropylene resin composition containing a propylene-ethylene block copolymer which satisfies four requirements such as sequential polymerization with a metallocene catalyst, a specific fiber and optionally a specific modified polyolefin, a thermoplastic elastomer which satisfies two requirements such as mfr, a specific propylene polymer resin and a specific fatty acid amide..
| Polypeptide having phytase activity and increased temperature resistance of the enzyme activity, and nucleotide sequence coding said polypeptide|
The invention relates to a recombinant dna molecule encoding a polypeptide having phytase activity and increased temperature stability and increased proteolytic stability of the enzyme activity. The dna sequence has been obtained by variation of the mature wild-type e.
| Immunogenic compositions and uses thereof|
This invention generally relates to immunogenic compositions that comprise an rna component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in rna-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen.
| Spray dried compositions and methods of use|
Provided herein are insoluble particles that include polypeptides. The polypeptides may have immunogenicity that is greater than the immunogenicity of the same polypeptides when they are not present in the particle.
| Influenza hemagglutinin and neuraminidase variants|
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.. .
| Antibody variants and uses thereof|
Described herein are polypeptides and related antibodies comprising a variant fc domain. The variant fc domain provide for stabilized fc:fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as cdc-response..
| Methods for preventing and/or treating nasal polyps and rhinosinusitis|
The invention is directed to methods for preventing and/or treating nasal polyps. The invention is further directed to methods for preventing and/or treating rhinosinusitus.
| Topical sunscreen compositions|
Substantially anhydrous compositions including at least 10% by weight of a c2 or c3 mono-alcohol, a solid, organic uv-filter dissolved therein; and an oil portion including one or more oils, the oil portion having an interfacial tension with water of greater than 9 and less than 45, where the composition has a volume fraction of oil relative to oil plus c2 or c3 mono-alcohol that is about 0.47 or greater, and is substantially free of a mixture of a low-volatility, c2-c8 liquid silicone and a branched fatty acid ester of a polyprotic carboxylic acid in a ratio of from about 3:1 to 4.25:1.. .
| Oral care compositions|
The present invention relates to oral compositions, comprising select polyethylene oxide-polypropylene oxide block copolymer surfactants. Methods for using the compositions are also disclosed..
| Oral care compositions|
The present invention relates to oral compositions, comprising select polyethylene oxide-polypropylene oxide block copolymer surfactants. Methods for using the compositions are also disclosed..
| Photopolymerizable inkjet ink|
To provide a photopolymerizable inkjet ink, which contains photopolymerizable monomers containing at least one selected from the following compound group (a) compounds of which are negative for skin sensitization, and at least one selected from the following compound group (b) compounds of which are negative for skin sensitization, wherein the compound group (a) is a compound group consisting of caprolactone-modified dipentaerythritol hexaacrylate, polyethoxylated tetramethylol methane tetraacrylate, ethylene oxide-modified bisphenol a diacrylate, caprolactone-modified hydroxy pivalic acid neopentyl glycol diacrylate, polypropylene glycol diacrylate [ch2═ch—co—(oc3h6)n-ococh═ch2 (n≈12)], hydroxyethyl acryl amide, trimethylol propane trimethacrylate, and tricyclodecane dimethanol dimethacrylate, and the compound group (b) is a compound group consisting of ethylene oxide-modified phenolacrylate, isostearyl acrylate, ethylene oxide-modified trimethylol propane trimethacrylate, stearyl methacrylate, and glycerin dimethacrylate.. .
| Combination and modified electrolyte to reduce risk of premature lithium ion battery failure, including in aircraft applications|
A combined system reinforces the safety of lithium ion batteries by redesign of electrolyte and the charging current a) modifying the electrolyte to inhibit or prevent dendrite growth preferably by the addition of lithiated polyphenoxy polyethylene glycol and/or a second surface active compound chosen from the family of fluorosurfactants, and/or a modest amount of lithium or sodium borate, b) modifying the charging cycle by a so-called ripple current in order to inhibit or prevent dendrite growth (ripple current meaning oscillation in the amount of amperage or voltage in the charging cycle), c) programmable battery management systems with temperature and electrical limits integrated in order to eliminate from the circuit and bypass malfunctioning cells based on past performance of the charging cycle and voltage endpoints achieved, d) minimizing any transient currents and voltages into or out of the battery system and e) maintaining a cool atmosphere in the battery space.. .
| Methods for manufacturing a paint roller and component parts thereof with composite cover having compounded material|
Described are methods of making a paint roller using material made from a compound of polypropylene and calcium carbonate having between 5% and 66% calcium carbonate by weight. One or various compounds may be used to form portions of one or multiple components that make up the paint roller, including, for example, the thermoplastic strips, adhesives and/or the backing of a composite cover material.
| Methods for manufacturing a paint roller and component parts thereof with strips of compounded material|
Described are methods of making a paint roller using preformed strips or core material made from a compound of polypropylene and calcium carbonate having between 5% and 66% calcium carbonate by weight. One or various compounds may be used to form portions of one or multiple components that make up the paint roller, including, for example, the thermoplastic strips, adhesives and/or the backing of a composite cover material.
| Bi-component fiber and filter media including bi-component fibers|
A bi-component fiber is provided. The bi-component fiber includes a sheath formed of polyphenylene sulfide (pps) and a core formed of a high glass transition polyester.
|Plants having enhanced yield-related traits and a method for making the same|
The present invention provides a method for enhancing various economically important yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a patl (patellin) polypeptide, a prp38 (precursor rna processing factor 38) polypeptide, an ada2 (adaptor 2) polypeptide, a gata-like polypeptide, or a wd40 repeat (wdr) 23-like polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a patl polypeptide, a prp38 polypeptide, an ada2 polypeptide, a gata-like polypeptide, or a wdr23-like polypeptide, which plants have improved yield-related traits relative to corresponding wild type plants or other control plants.
|Methods and systems for experimental set-up and data analysis in targeted proteomics applications|
The invention relates to the analysis of compounds with mass spectrometry and more particularly to instruments, substances, and methods for polypeptide analysis, in particular in targeted proteomics applications and based on indexed retention time as peptide specific property. The method of chemical analysis comprises the steps of: a) providing a first complex sample comprising a set of at least two reference peptides associated to an indexed retention time scale (irt), as well as at least one further peptide; b) performing lc-ms on said complex sample and determining the empirical retention time values (rte) of the reference peptides and of the at least one further peptide; c) translating the empirical retention time values (rte) of the reference peptides and of the at least one further peptide into the indexed retention time scale and associating to each reference peptide a reference indexed retention time value (irtr) and to the at least one further peptide an associated indexed retention time value (irta); d) providing a second complex sample comprising at least one polypeptide as well as said set of the at least two reference peptides; e) performing lc-ms on said second complex sample and determining the empirical retention time values (rte) of the reference peptides; f) translating the empirical retention time values (rte) of the reference peptides into the indexed retention time scale by numerically adapting the transformation function for the conversion of the retention time values (rte) into indexed retention time values such that the calculated indexed retention time values (irte) calculated based on the measured retention time values (rte) of the reference peptides match the assigned indexed retention time values (irtr) of the reference peptides; g) determining the predicted empirical retention time value (rtp) of the at least one further peptide by using the numerically adapted transformation function determined in step f)..
|Rank ligand polypeptides|
Described herein are kits for use in detecting rankl polypeptides.. .
|Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same|
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein.
|Polypropylene and polylactic acid formulations for heat seal applications|
Films (or a cap layer of co-extruded films) and methods of forming the same are described herein. The films generally include a modified olefin based polymer including polypropylene and from 1 wt.
|Flame retardant thermoplastic resin composition|
A polycarbonate resin composition includes (a) about 90 to about 97% by weight of a rubber-reinforced polystyrene resin, (b) about 3 to about 10% by weight of a polyphenylene ether resin, (c) about 10 to about 20 parts by weight of a halogen compound including a triazine group, or a mixture of a halogen compound including a triazine group and a diphenyl ethane bromide compound based on about 100 parts by weight of a base resin comprising (a) and (b), and (d) about 0.01 to about 3 parts by weight of an antimony compound based on about 100 parts by weight of the base resin comprising (a) and (b). The composition can exhibit excellent flame retardancy, colorability and injection molding thermal stability..
|Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid|
An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. Since even in the case where a preservative is incorporated into said aqueous liquid preparation, the preservative exhibits a sufficient preservative effect for a long time, said aqueous liquid preparation in the form of an eye drop is useful for the treatment of blepharitis, conjunctivitis, scleritis, and postoperative inflammation.
|Pharmaceutical compounds for use in the therapy of clostridium difficile infection|
The invention relates to a compound described by a general formula (1), wherein each x independently can be opo32−, opso22− or oso3−; r1 comprises a solubility function such as a polyethylene glycol moiety and each x independently can be opo32−, opso22−, − or oso3−; and z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms. The invention further relates to polysulfate derivatives or mixed polyphosphate/sulphate derivatives of six-membered cyclic polyols for use in the therapy of infection by clostridium difficile..
|Compositions and methods for introduction of macromolecules into cells|
Disclosed are novel compositions and methods for introduction of macromolecules and nanoparticles into living cells. The invention includes a polypeptide sequence which when fused to a macromolecule or nanoparticle enhances its introduction into the cell..
|Stabilized polypeptides as regulators of rab gtpase function|
The present invention provides inventive polypeptides comprising a c terminal rab binding domain (rabbd) of rab family interacting proteins (fips) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating rab function comprising contacting an inventive stapled polypeptide with a rab protein, and methods of treatment associated with modulation of rab activity.
|Stabilized insulin-like growth factor polypeptides|
The invention relates to stabilized polypeptides having an igf-1 or igf-2 sequence and an e-peptide sequence, where the natural physiological cleavage of the e-peptide from the igf is prevented.. .
|Engineered polypeptides having enhanced duration of action with reduced immunogenicity|
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration, and reduced immunogenicity. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides.
|Assay for inhibitors of cip/kip protein degradation|
An assay and system compatible with high throughput screening (hts) that is capable of identifying inhibitors, such as small-molecule inhibitors, of the degradation of the cdk inhibitor p21, are described. The assay is based on the use of fusion protein comprising (i) a p2 polypeptide; and (i) a reporter protein linked to the c-terminal of said p21 polypeptide, wherein the fusion protein has a half-life that is similar to that of the p21 polypeptide.
|Immunoglobulin fc polypeptides|
Methods and compositions involving polypeptides having an aglycosylated antibody fc domain. In certain embodiments, polypeptides have an aglycosylated fc domain that contains one or more substitutions compared to a native fc domain.
|Protease-resistant systems for polypeptide display and methods of making and using thereof|
The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.. .
|Resin composition, prepreg and their uses|
A vinyl-compound-based resin composition containing a terminal vinyl compound (a) of a bifunctional phenylene ether oligomer having a polyphenylene ether skeleton, a specific maleimide compound (b), a naphthol aralkyl type cyanate ester resin (c) and a naphthalene-skeleton-modified novolak type epoxy resin (d) for a high-multilayer and high-frequency printed wiring board, which resin composition is excellent in varnish shelf life at low temperature and does not show a decrease in multilayer moldability, heat resistance after moisture absorption, electrical characteristics and peel strength even in a winter period and for a long period of time, and a prepreg, a metal-foil-clad laminate and a resin sheet each of which uses the above resin composition.. .
|Aqueous adhesive composition based on polyaldehyde and polyphenol|
An aqueous adhesive composition includes: a phenol/aldehyde resin; and an unsaturated elastomer latex. The phenol/aldehyde resin is based on: an aromatic polyaldehyde bearing at least two aldehyde functional groups and including at least one aromatic nucleus; and a polyphenol including at least one aromatic nucleus.