|| List of recent Polyp-related patents
| Nuclease fusion protein and uses thereof|
The present invention is concerned with nuclease fusion proteins and various uses thereof. Specifically, it relates to a polynucleotide encoding a polypeptide comprising (i) a first module comprising at least a first dna binding domain derived from a homing endonuclease, (ii) a linker, and (iii) a second module comprising at least a second dna binding domain and a cleavage domain derived from a restriction endonuclease, wherein said polypeptide functionally interacts only with dna comprising a dna recognition site for the first dna binding domain and a dna recognition site for the second dna binding domain, and wherein said cleavage domain cleaves dna within a specific dna cleavage site upon binding of the polypeptide.
| Heterophasic copolymers|
A heterophasic polypropylene resin comprising a polypropylene homopolymer matrix phase (a) and an ethylene-propylene copolymer phase (b) dispersed within the matrix, wherein the xylene soluble fraction of the heterophasic polypropylene resin is in the range 20 to less than 50 wt %; the heterophasic polypropylene resin has an mfr2 of 0.01 to 50 g/10 min; the ethylene content of the xylene soluble fraction of the heterophasic polypropylene resin is in the range of at least 20 wt % to less than 50 wt %; the heterophasic polypropylene resin has a notched charpy impact strength at −20 c of at least 25 kj/m2, preferably at least 50 kj/m2; and wherein the mfr2 (matrix)/mfr2(xs)≧5, preferably ≧10.. .
| Resin composition and method of producing the same|
A resin composition having a high thermal aging property and molding stability in mass production of molded articles while keeping molding fluidity and thermal creep resistance is provided. A resin composition, containing 100 parts by mass in total of a polypropylene resin (a) and a polyphenylene ether resin (b), and 1 to 20 parts by mass of a compatibilizer (c), wherein in the component (a), the proportion of the component having a molecular weight of 30,000 or less is from 3.0 to 5.1% of the entire component (a), and the proportion of the component having a molecular weight of 10,000,000 or more is from 1.0 to 1.6% of the entire component (a)..
| Polyolefin-based resin composition|
Disclosed are a polyolefin-based resin composition having excellent scratch resistance and low glossiness, a preparation method thereof, and automobile interior and exterior materials fabricated therefrom. The polyolefin-based resin composition comprises about 56 to 97% by weight of a polypropylene block copolymer resin, about 1 to 9% by weight of a thermoplastic elastomer rubber, about 1 to 30% by weight of an inorganic filler, and about 1 to 5% by weight of a fluoroacrylamide-based copolymer based on a total weight of the composition..
| Expression of il-12 family heterodimers|
The present invention provides methods of improving the levels and stability of expression of interleukin-12 family cytokine polypeptides by expressing the alpha and beta subunits of the polypeptides at their determined relative molar ratios that increase the levels and stability of expression of the heterodimer, e.g., in comparison to heterodimer expressed at an equimolar ratio.. .
| Phenolic coatings and methods of making and using same|
A method of making a facile, surface-independent, polyphenol coating is disclosed. In general, the method includes contacting at least a portion of the substrate to be coated with an aqueous solution containing one or more salts and one or more nitrogen-free phenolic compounds.
| Polypeptides for treating and/or limiting influenza infection|
Polypeptides are disclosed herein, which recognize and are strong binders to influenza a hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection.. .
| T cell receptors and related materials and methods of use|
The invention provides t cell receptors (tcrs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions.
| Engineered polypeptide agents for targeted broad spectrum influenza neutralization|
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (ha) polypeptides and/or ha receptors, and reagents and methods relating thereto.
| Polypeptides having protease activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
| Universal fibronectin type iii binding-domain libraries|
Walk-through mutagenesis and natural-variant combinatorial fibronectin type iii (fn3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens..
| Biomarkers for psoriasis|
A group of polypeptides that are modulated in a psoriatic sample as compared to a normal sample is provided. These polypeptides can be used as biomarkers for diagnosis and monitoring treatment of psoriasis..
| Nucleic acid construct, nucleic acid-protein complex, and use thereof|
Using a nucleic acid construct, association of a polypeptide with a sequence coding therefor and screening of a polypeptide that binds to a target substance are carried out, which nucleic acid construct comprises a 5′-untranslated region and a coding region, wherein the above-mentioned coding region comprises a sequence coding for a polypeptide subjected to be displayed, a sequence coding for a first nucleic acid binding polypeptide, and a sequence coding for a second nucleic acid binding polypeptide; the above-mentioned 5′-untranslated region comprises a first sequence capable of binding to a first nucleic acid binding polypeptide and a second sequence capable of binding to second nucleic acid binding polypeptide; and, when the above-mentioned nucleic acid construct is introduced in a translation system, a fusion protein translated from the coding region of the above-mentioned nucleic acid construct forms a complex with an rna corresponding to the above-mentioned nucleic acid construct.. .
| Vector with codon-optimised genes for an arabinose metabolic pathway for arabinose conversion in yeast for ethanol production|
The present invention relates to novel expression cassettes and expression vectors, comprising three nucleic acid sequences for araa, arab and arad, each coding for a polypeptide of an l-arabinose metabolic pathway, in particular, a bacterial l-arabinose metabolic pathway. The invention particularly relates to expression cassettes and expression vectors, comprising codon-optimised nucleic acid sequences for araa, arab and arad.
| Bioactive carbon nanotube composite functionalized with b-sheet polypeptide block copolymer, and preparation method thereof|
The present invention relates to a bioactive carbon nanotube composite functionalized with a β-sheet polypeptide block copolymer by combination self-assembly, which shows excellent water dispersion, and has biological activity so as to be used as stimulus-responsive and adaptable biomaterials or in the manufacture of cnt-based electronic biosensor devices. In addition, the bioactive carbon nanotube composite can be used as a composition for delivery of a biological active material into cells.
| Method of enzymatically synthesizing 3' -phosphoadenosine-5'-phosphosulfate|
The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (paps), the method including subjecting atp to sulfation and phosphorylation by use of adenosine 5′-triphosphate sulfurylase (atps) and adenosine 5′-phosphosulfate kinase (apsk), wherein an adenosine 5′-triphosphate (atp) supply/regeneration system including adenosine 5′-monophosphate (amp), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (pndk), and polyphosphate:amp phosphotransferase (pap), or an adenosine 5′-triphosphate (atp) supply/regeneration system including adenosine 5′-monophosphate (amp), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (pndk), and adenylate kinase (adk) is employed instead of atp.. .
| Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy|
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell.
| Use of proline specific endoproteases to hydrolyse peptides and proteins|
The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a ph of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.. .
| Polypeptides having glucoamylase activity and polynucleotides encoding same|
Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains..
| Multilayer blown films|
Coextruded multilayer blown films are produced comprising: a core layer comprising at least one random polypropylene copolymer; at least one skin or intermediate layer adjacent to said core layer; wherein the coextruded multilayer film has at least about 30% higher machine direction tear, at least about 30% improved tear ratio (machine direction tear divided by transverse direction tear) and at least about 10% lower film haze, relative to a similar multilayer film comprising at least one impact polypropylene copolymer in the core layer.. .
| Novel method and compositions|
The present invention relates to, inter alia, a method of raising an immune response against a pathogen which comprises administering (i) one or more first immunogenic polypeptides derived from said pathogen; (ii) one or more adenoviral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from said pathogen; and (iii) an adjuvant; wherein the one or more first immunogenic polypeptides, the one or more adenoviral vectors and the adjuvant are administered concomitantly. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing said polypeptides, adenoviral vectors and adjuvants..
| Methods to increase antigenicity of membrane-bound polypeptides produced in plants|
Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds from the plant is such that phospholipids are associated with the polypeptide. Reducing fat by supercritical fluid extraction increases antigenicity of such plant-produced membrane-bound polypeptides.
| Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders|
The present invention relates to amino acid sequences that are directed against rank-l, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes..
| Polypeptide that binds aberrant cells and induces apoptosis|
Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an mhc-peptide complex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes.
| Composition and method for increasing effectiveness of radiation or chemotherapy|
This invention is a composition containing prebiotics, lentinula edodes mycelia extract, and litchi chinensis fruit polyphenol and use of the same in increasing the effectiveness of radiation or chemotherapy and in the prevention, mitigation and/or treatment of colorectal neoplasia.. .
| Multimeric il-15 soluble fusion molecules and methods of making and using same|
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (il-15) polypeptide or a functional fragment thereof.
| Collecting and processing complex macromolecular mixtures|
This document provides methods and materials involved in collecting and processing complex macromolecular mixtures (e.g., stool samples). For example, stool collection devices, buffers for stabilizing nucleic acid and polypeptides present in stool, and kits for using sequence-specific capture probes (e.g., nucleic acid sequences designed to hybridize with particular target nucleic acids) to capture target nucleic acids directly from complex macromolecular mixtures (e.g., stool samples) without the need to perform prior steps to enrich, isolate, or purify the nucleic acid component are provided..
| Easy access non-woven plastic bags|
A non-woven laminated plastic bag having a weakened portion is provided. The weakened portion is generally defined by a plurality of perforations in the bag.
| Easy access woven plastic bags|
A woven laminated plastic bag having a weakened portion is provided. The weakened portion is generally defined by a plurality of perforations in the bag.
| Method for determining current in a polyphase machine|
In a method for determining current in a polyphase machine connected to a dc voltage source, a dc link is provided with a dc-link capacitor and, per phase, a high-side switch and a low-side switch. A measurement of the voltage curve across the dc-link capacitor is undertaken.
| In-mould labelling|
There is disclosed a method of manufacturing an in-mould labelled article, the method comprising the steps of: placing a label comprising a film having a core comprising polypropylene/polyethylene random copolymer as its principal polymeric constituent into a mould for injection moulding, thermoforming, or blow moulding; holding the label in position; injecting a polymeric melt into, or thermoforming or blowing a polymeric preform in said mould so as to bind with the label; and removing the article from the mould. A process of in-mould labelling using such a label is also disclosed..
|Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
|Polynucleotides and polypeptides in plants|
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
|Compositions and methods for altering alpha- and beta-tocotrienol content|
Preparation and use of isolated nucleic acids useful in altering the oil phenotype in plants. Isolated nucleic acids and their encoded polypeptides that alter alpha- and beta-tocotrienol content in seeds and oil obtained from the seeds.
|Polynucleotides and polypeptides that confer increased yield, size or biomass|
The present description relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant, including the traits of increased yield, size or biomass.. .
|Polyphenylene ether-based resin composition and method for producing the same|
To provide a resin composition that has a high impact resistance, hardly causes peeling during molding, and is excellent in flame retardancy, heat resistance, and heat aging resistance for a long period. A resin composition containing (a) polyphenylene ether, (b) a hydrogenated block copolymer that is obtained by hydrogenating a block copolymer including a polystyrene block and a conjugated diene compound polymer block, and that has a weight average molecular weight of 100,000 to 500,000, and (c) an organic phosphorus-based flame retardant within a specified amount, wherein a value of the loss tangent (tan δ) peak height of the (b) component in a dynamic viscoelasticity spectrum obtained by measurement of the resin composition at a frequency of 10 hz is in a specified range..
|Flame-retardant agent and flame-retardant resin composition|
The present invention provides a composite flame retardant which can be produced without using any toxic metal such as antimony trioxide or any halogen such as bromine and chlorine and can exhibit excellent flame retardancy compared with magnesium hydroxide when added in a smaller amount; and a flame retardant resin composition having excellent flame retardancy and excellent physical properties. The present invention relates to a flame retardant including: (a) 100 parts by mass of a reaction product of piperazine with one phosphorus compound selected from phosphoric acid, pyrophosphoric acid, and polyphosphoric acid; (b) 10 to 1000 parts by mass of a reaction product of melamine with a polyacid selected from cyanuric acid, phosphoric acid, pyrophosphoric acid, and polyphosphoric acid; and (c) 0.1 to 100 parts by mass of a reaction product of calcium or magnesium with silicic acid..
|Modified polynucleotides for treating carboxypeptidase n, polypeptide 1 protein deficiency|
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
|Wnt compositions and methods of use thereof|
Wnt compositions and methods for their use are provided. Compositions of the invention comprise fragments of wnt polypeptides having a desired biological activity, which fragments are referred to herein as “mini-wnts”.