|| List of recent Polyp-related patents
|Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
|Plants tolerant to abiotic stress|
The present invention provides genetically modified plants having increased tolerance to environmental abiotic stress, particularly to salt stress and water stress (drought). The tolerant genetically modified plants of the invention include transgenic plants overexpressing at least one inositol polyphosphate 5-phosphatase selected from 5tpase7 5tpase9 and plants having altered expression of the endonuclease/exonuclease/phosphatase (eep) protein zeep1..
|Genetically encoded calcium indicators and methods of use|
Genetically encoded calcium indicator (geci) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of g-protein coupled receptor (gpcr) or ion channels and methods of monitoring neural activity also are provided..
|Rational design of components of the oligo-saccharyltransferase-catalysed asparagine-linked glycosylation|
The present invention is directed to methods for identifying or designing (a) a potential oligosaccharide donor, (b) a potential oligosaccharyltransferase (ost), (c) a potential consensus sequence motif polypeptide, and/or (d) a potential glycosylation inhibitor for use in the oligosaccharyltransferase (ost)-catalysed asparagine-linked (“n-linked”) glycosylation, comprising the steps of generating a three-dimensional model of the catalytic domain and/or the polypeptide binding site of the oligosaccharyltransferase (ost) of campylobacter lari, and designing or selecting a potential component selected from (a) to (d) which optimizes the stereo chemical complementarity of said three-dimensional model(s) and the potential component.. .
|Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides|
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group.
|Novel immunoglobulin-binding polypeptide|
An object of the present invention is to provide novel polypeptides that are capable of binding to an immunoglobulin and have high stability against alkali. The present invention relates to proteins having the amino acid sequence of seq id no:1 or 2..
|Blends of micronized polyphenylene ether and thermoplastic polyurethanes blend|
Also disclosed are processes for preparing such blends as well as articles derived therefrom.. .
|Polyphenylene sulfide resin composition and molding comprising same (as amended)|
The invention provides a polyphenylene sulfide resin composition including: 1 to 100 parts by weight of an olefin elastomer (b); and 0.01 to 10 parts by weight of a carboxylic acid amide wax mixture (c), relative to 100 parts by weight of a polyphenylene sulfide resin (a), wherein the carboxylic acid amide wax mixture (c) is obtained by adding 0.01 to 5 parts by weight of an antioxidant to 100 parts by weight of a carboxylic acid amide wax produced by reaction of a higher aliphatic monocarboxylic acid, a polybasic acid and a diamine.. .
|Liver cancer diagnosis marker and use thereof|
A marker for the detection of liver cancer and application of the marker thereof. The application includes use of cytochrome p450 family 17 subfamily a polypeptide 1 (cyp17a1 protein) in the preparation of diagnostic reagents or kits for the detection of liver cancer kit.
|Fluorescent detection of in vitro translated protein on a solid surface|
Disclosed herein are methods and kits useful in the detection of protein folding and in the identification of compounds that promote proper protein folding. In one example approach, fluorophores and a protein tag are incorporated into a nascent polypeptide within a ribosome-nascent-chain complex during cell free translation and the resulting labeled ribosome-nascent-chain complex is conjugated to a solid surface via the tag.
|Antibody polypeptides that antagonize cd40l|
Antibody polypeptides that specifically bind human cd40l are provided. The antibody polypeptides do not activate platelets.
|Compositions and methods for enhancing production of a biological product|
The invention provides compositions and methods for producing a biological product from a host cell. In various embodiments, the biological product is a polypeptide, a metabolite, a nutraceutical, a chemical intermediate, a biofuel, a food additive, or an antibiotic.
|Composites containing polypeptides attached to polysaccharides and molecules|
This document provides methods and materials related to composites or coatings containing polypeptides attached to polysaccharides and/or molecules. For example, methods and materials related to composites or coatings containing polypeptides (e.g., casein polypeptides) attached to polysaccharides (e.g., cellulose) and/or molecules (e.g., calcium containing molecules such as calcium phosphate and calcium carbonate and/or polyesters such as polylactic acid and polyhydroxybutyrate) are provided.
|Asparaginase enzyme variants and uses thereof|
The present invention relates to newly identified asparaginase polypeptide variants of seq id no: 3 and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes..
|Dentifrice containing zinc ions and polyphosphate ions|
The invention includes a dentifrice composition that comprises a zinc ion source, a polyphosphate ion source, an anethole and a silica. The silica has a mean particle size of about 5 to about 12 microns, an einlehner hardness of about 1 to about 20, and an oil absorption of about 40 to less than about 100 cc/100 g.
The present invention provides a therapeutic or improving agent for a lifestyle-related disease, containing an expression vector encoding a chimeric hepatitis b virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of the lifestyle-related disease-related factor, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis b virus core antigen polypeptide.. .
|Antibody polypeptides that antagonize cd40|
Antibody polypeptides that specifically bind a novel epitope of human cd40 are provided. The antibody polypeptides do not exhibit cd40 agonist activity.
|S. aureus polypeptide and antibodies|
The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to manufacture said polypeptides, vaccines and antibodies.. .
|New dendritic cell co-stimulatory molecules|
A novel costimulatory protein molecule, b7-dc, which is a member of the b7 family, is described as is dna coding therefor and expression vectors comprising this dna. B7-dc protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing b7-dc are useful in vaccine compositions and methods.
The present invention relates to recombinant ace2 polypeptide, where the ace2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
|Biotherapy for pain|
The present invention is directed to analgesic clostridial neurotoxin derivatives comprising polypeptides having a long-lasting snare protein-selective endopeptidase activity. These derivatives selectively bind to and are internalized by non-neuronal cells secreting cytokines or sensory neurons in preference to motor neurons or autonomic neurons.
|Novel superactive il-33 fragments, and uses thereof|
The present invention discloses novel active polypeptide fragments of human il-33 corresponding to natural forms generated by the proteases of human neutrophils (cathepsin g, elastase 2, proteinase 3), as well as the use thereof as a drug, in particular for the treatment of infectious diseases, inflammatory diseases, atherosclerosis, cardiovascular diseases, obesity, or cancer.. .
|System and method for a mesh power system|
A power mesh system and method comprising at least three polyphase power devices of a plurality of polyphase power devices, each having a phase connection for each phase, where each polyphase power device has each phase connection coupled to at least one phase connection of another polyphase power device to form a two dimensional array of power devices.. .
|Steering column assembly for a motor vehicle|
A steering column assembly for a motor vehicle is provided. The steering column assembly may include a main steering column shaft; a first tubular member; a first attachment feature; and a second attachment feature.
|Methods for production of proteins|
The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies thereby facilitating rapid isolation and purification of recombinant proteins.
|Multi-layer material for application to a vehicle underbody|
A dual layer material adapted to being applied to a vehicle underbody including a panel shaped body formed by a moldable polyethylene terephthalate (pet) layer joined with a polypropylene and glass composite layer in order to provide at least one of improved wear and abrasion resistance on an outer facing surface and acoustic noise attenuation on an inner vehicle facing surface. The dual layer material can also incorporate a bonding agent for adhering the layers together..
|Polypeptides having endoglucanase activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
|Plants having enhanced yield-related traits and a method for making the same|
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a tcp1 or a tcp2 transcription factor, an epsin-like polypeptide, a trna delta(2)-isopentenylpyrophosphate transferase (ippt) polypeptide, or a short-root (shr) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a tcp1 or tcp2 polypeptide, an epsin-like polypeptide, a trna delta(2)-isopentenylpyrophosphate transferase (ippt) polypeptide, or a short-root (shr) polypeptide, which plants have enhanced yield-related traits relative to corresponding wild type plants or other control plants.
|Axmi232, axmi233, and axmi249 toxin genes and methods for their use|
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
|Modified polyphenol binder compositions and methods for making and using same|
Modified polyphenol binder compositions and methods for making and using same are provided. In at least one specific embodiment, the binder composition can include at least one unsaturated monomer and at least one polyphenolic compound.
|Reinforced hdpe compounds with improved mechanical properties and methods of making same|
A thermoplastic polyolefin composition comprising, based on the total mass of the composition, 10-75% by mass of high density polyethylene (hdpe), 8-30% by mass of elastomer, and 5-45% by mass of filler, wherein the composition has a melt flow rate of 1.0-20 g/10 min according to iso 1133 at 190° c./2.16 kg. The thermoplastic polyolefin composition is produced in a method comprising batch mixing or continuous mixing the hdpe, elastomer, and filler to form a melt blend, and cooling the melt blend to give the product.
|Thermoplastic elastomer compounds exhibiting superior compression set properties|
A blend of polyisobutylene-based thermoplastic vulcanizate, styrene-ethylene-ethylene-propylene-styrene, low molecular weight liquid polybutene, polyolefin, polyphenylene ether, and, optionally, filler is disclosed which has good processability, lower compression set, and more effective barrier properties for oxygen than the same blend without the styrene-ethylene-ethylene-propylene-styrene and the polyphenylene ether. The blend is superior in oxygen transmission rate properties than a conventional styrenic block copolymer containing thermoplastic elastomer..
|Composition and method for neuroprotection against excitotoxic injury|
The present invention discloses the combined treatment of memantine (n-methyl-d-aspartate receptor antagonist) and tea polyphenol (an antioxidant and anti-inflammatory agent) is more effective (synergistic) in neuroprotection than either memantine or tea polyphenol alone in mouse excitotoxic injury. These findings provide useful information about the potential application of memantine and tea polyphenols in preventing or treating clinical excitotoxic injury such as brain trauma, brain ischemia, epilepsy, and alzheimer's disease..
|Ssh-2 (slingshot-2) inhibitors and methods for making and using them|
In alternative embodiments, the invention provides compositions that inhibit the polypeptide ssh-2, or slingshot-2, a phosphatase enzyme that regulates actin filaments, and methods for making and using them, including methods comprising administering compositions of the invention to regulate or modify actin filament polymerization by inhibiting ssh-2, where in one embodiment compositions of the invention slow or inhibit f-actin depolymerization and severing. In alternative embodiments, compositions and methods of the invention are used to slow or inhibit cell motility and/or internal remodeling.
|Methods and reagents for efficient and targeted delivery of therapeutic molecules to cxcr4 cells|
The invention relates to conjugates comprising a targeting moiety specific for the cxcr4 based on the polyphemusin-derived peptide and a therapeutic or imaging agent. The invention relates as well to the application of said conjugates for the therapy and diagnostics which require the specific targeting to cxcr4+ cells..
|Mitrecin a polypeptide with antimicrobial activity|
The present invention provides a mitrecin a polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a mitrecin a polypeptide.
|Stromal antigen 2 (stag2) compositions and methods|
Compositions and methods related to stromal antigen 2 (stag2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.. .
|Heat curable composite textile|
A heat curable, circular knitted fabric includes reinforcing and meltable resin fibers that can be cured to form a more rigid material form. In one embodiment, the fabric includes a core spun yarn, wherein the core may be made from glass, carbon, basalt, aramid or metal.
|Expression systems and methods of producing spider silk proteins|
An expression system, including a host cell, a synthetic spider silk polypeptide-encoding nucleotide sequence, at least one synthetic trna molecule-encoding nucleotide sequence or a synthetic serine hydroxymethyl transferase (shmt)-encoding nucleotide sequence.. .
|Modified human thymic stromal lymphopoietin|
Modified, furin resistant human tslp polypeptides and polynucleotides encoding the modified human tslp polypeptides are provided. Pharmaceutical compositions, b and t cell activation agents, assays and methods of use are also described..
|Prokaryotic rnai-like system and methods of use|
Provided herein are methods for inactivating a target polynucleotide. The methods use a psirna having a 5′ region and a 3′ region.
|Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same|
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
|Type ii restriction modification system methylation subunit of alicyclobacillus acidocaldarius|
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from alicyclobacillus acidocaldarius..
|Polypeptides with ketol-acid reductoisomerase activity|
Polypeptides having ketol-acid reductoisomerase activity are provided. Also disclosed are recombinant host cells comprising isobutanol biosynthetic pathways employing such polypeptides.
|Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria|
Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria are described. Additionally, variant or recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided..
|Polypeptides having endoglucanase activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
|Marker comprising anti-ck8/18 complex autoantibody and its use for diagnosing cancer|
The present invention relates to a cytokeratin 8/18 complex-specific autoantibody or a fragment comprising an antigen-binding site (paratope) thereof, the use thereof in the diagnosis of breast cancer, a polypeptide having an amino acid sequence of an epitope specifically binding to the autoantibody, a composition for diagnosing breast cancer comprising an agent capable of measuring an expression level of the autoantibody or the fragment comprising an antigen-binding site thereof, a hybridoma cell line producing the autoantibody, and a kit for diagnosing breast cancer comprising the composition of the present invention. Further, the present invention relates to a method for diagnosing breast cancer, comprising the step of detecting the cytokeratin 8/18 complex-specific autoantibody or the fragment comprising the antigen-binding site thereof using the composition of the present invention, and a method for screening a therapeutic agent for breast cancer using the autoantibody..
|Highly pure plasmid dna preparations|
The present disclosure generally relates to highly pure plasmid compositions having low, or undetectable, levels of colanic acid and other contaminants made by a process that includes the steps of obtaining a crude lysate of a plasmid dna from a bacteria that makes colanic acid; treating the partially purified or purified plasmid dna with a polypeptide that digests colanic acid under conditions that digest the colanic acid; and purifying the plasmid dna from the digested colanic acid and the colanic acid degrading enzyme by one or more chromatography steps.. .
|Digital overlaminate films|
The present subject matter relates to a non-pvc film and film laminate for use in marketing or advertising campaigns, for indoor or outdoor use, or other environment impacted promotions and safety applications. One embodiment of the film includes three layers.
|Ultra clear scratch resistant coating and laminate|
An ultra-clear rub and scratch resistant aqueous based coating that provides barrier properties to film and is receptive to flexo, litho, and gravure printing inks includes polyurethane acrylic hybrid dispersion in combination with melamine formaldehyde resin and micronized wax. The coating composition can be formulated with little or no n-methylpyrrolidone.
|Immunogenic compositions and expression systems|
Immunogenic compositions and vaccines against plasmodial infection comprising an rh polypeptide or a fragment or variant thereof are disclosed. Also disclosed are rh5 polypeptides or fragments or variants thereof capable of binding cd147 and conferring protection against infection and/or disease caused by multiple plasmodial strains or plasmodial species, inhibitors of the interaction between rh5 and cd147 and methods for producing polypeptides in a mammalian expression system..
|Compositions and methods of enhancing immune responses|
Provided herein are salmonella enteritidis 13a strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against influenza a and methods of reducing morbidity associated with an influenza a infection.
|Polypeptides and vectors for targeting her2/neu expressing cells and uses thereof|
Various aspects of the invention provide for capsids, parvovirus capsids, hybrid parvovirus capsids, parvovirus vectors, hybrid parvovirus vectors, hybrid parvovirus particles and parvovirus particles containing polypeptides in which the sequence ycdgfyacymdv (seq id no: 3) has been substituted into the vp2 loop of the b19 capsid protein. Polypeptides in which the sequence ycdgfyacymdv (seq id no: 3) has been substituted into the vp2 loop of the b19 capsid protein are also provided (e.g., seq id no: 2).
|Immunogenic compositions in particulate form and methods for producing the same|
The invention relates to the field of immunology and vaccine development, in particular to the development of vaccines based on native antigen oligomers. Provided is an immunogenic composition in particulate form, comprising oligomers of a surface exposed polypeptide of pathogenic origin or tumour origin, or antigenic part thereof, said oligomers being bound non-covalently to a particulate carrier, and a pharmaceutically acceptable diluent or excipient.
|Lutzomyia longipalpis polypeptides and methods of use|
Substantially purified salivary lu. Longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed.
|Deletion of the beta 20-21 loop in hiv gp120 exposes the cd4 binding site for improved antibody binding and antibody induction|
Disclosed herein are isolated immunogens including variant gp120 polypeptides. In an example, a variant gp120 polypeptide includes a deletion of at least 8 consecutive residues of the fourth conserved loop (c4) between residues 419 and 434 of gp120 according to hxb2 numbering.
|Modified chaperonin 10|
The present invention relates to isolated chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.. .
|Fc-gamma-riib-specific fc antibody|
An objective of the present invention is to provide a polypeptide containing an fc region having maintained or decreased binding activities towards both allotypes of fcγriia, types h and r, and having enhanced fcγriib-binding activity in comparison with a parent polypeptide; a pharmaceutical composition containing the polypeptide; an agent for treating or preventing immunological inflammatory diseases that includes the pharmaceutical composition; a production method thereof; and a method for maintaining or decreasing binding activities towards both allotypes of fcγriia and enhancing the fcγriib-binding activity. Specifically, it is found that a polypeptide containing an antibody fc region that has an alteration of substituting pro at position 238 (eu numbering) with asp or leu at position 328 (eu numbering) with glu enhances fcγriib-binding activity, and maintains or decreases binding activities towards both allotypes of fcγriia, types h and r.
|Modulating bacterial mam polypeptides in pathogenic disease|
The disclosure relates to methods and compositions for preventing or inhibiting pathogenic bacterial infections in a subject caused by pathogenic bacteria expressing a multivalent adhesion molecule (mam) polypeptide by administering to a subject a composition comprising a mam polypeptide or a non-pathogenic bacterium expressing a mam polypeptide, or a combination thereof.. .
|Distributed polyphase filter|
In one embodiment, an apparatus includes a clock generator to generate differential clock signals. The apparatus also includes a distributed polyphase filter to obtain phase-corrected multi-phase clock signals based on the differential clock signals..