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Polyp patents



      
           
This page is updated frequently with new Polyp-related patent applications. Subscribe to the Polyp RSS feed to automatically get the update: related Polyp RSS feeds. RSS updates for this page: Polyp RSS RSS


Methods and systems for experimental set-up and data analysis in targeted proteomics applications

Date/App# patent app List of recent Polyp-related patents
08/21/14
20140237687
 Plants having enhanced yield-related traits and a method for making the same patent thumbnailPlants having enhanced yield-related traits and a method for making the same
The present invention provides a method for enhancing various economically important yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a patl (patellin) polypeptide, a prp38 (precursor rna processing factor 38) polypeptide, an ada2 (adaptor 2) polypeptide, a gata-like polypeptide, or a wd40 repeat (wdr) 23-like polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a patl polypeptide, a prp38 polypeptide, an ada2 polypeptide, a gata-like polypeptide, or a wdr23-like polypeptide, which plants have improved yield-related traits relative to corresponding wild type plants or other control plants.
08/21/14
20140236497
 Methods and systems for experimental set-up and data analysis in targeted proteomics applications patent thumbnailMethods and systems for experimental set-up and data analysis in targeted proteomics applications
The invention relates to the analysis of compounds with mass spectrometry and more particularly to instruments, substances, and methods for polypeptide analysis, in particular in targeted proteomics applications and based on indexed retention time as peptide specific property. The method of chemical analysis comprises the steps of: a) providing a first complex sample comprising a set of at least two reference peptides associated to an indexed retention time scale (irt), as well as at least one further peptide; b) performing lc-ms on said complex sample and determining the empirical retention time values (rte) of the reference peptides and of the at least one further peptide; c) translating the empirical retention time values (rte) of the reference peptides and of the at least one further peptide into the indexed retention time scale and associating to each reference peptide a reference indexed retention time value (irtr) and to the at least one further peptide an associated indexed retention time value (irta); d) providing a second complex sample comprising at least one polypeptide as well as said set of the at least two reference peptides; e) performing lc-ms on said second complex sample and determining the empirical retention time values (rte) of the reference peptides; f) translating the empirical retention time values (rte) of the reference peptides into the indexed retention time scale by numerically adapting the transformation function for the conversion of the retention time values (rte) into indexed retention time values such that the calculated indexed retention time values (irte) calculated based on the measured retention time values (rte) of the reference peptides match the assigned indexed retention time values (irtr) of the reference peptides; g) determining the predicted empirical retention time value (rtp) of the at least one further peptide by using the numerically adapted transformation function determined in step f)..
08/21/14
20140235832
 Rank ligand polypeptides patent thumbnailRank ligand polypeptides
Described herein are kits for use in detecting rankl polypeptides.. .
08/21/14
20140235823
 Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same patent thumbnailFusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein.
08/21/14
20140235791
 Polypropylene and polylactic acid formulations for heat seal applications patent thumbnailPolypropylene and polylactic acid formulations for heat seal applications
Films (or a cap layer of co-extruded films) and methods of forming the same are described herein. The films generally include a modified olefin based polymer including polypropylene and from 1 wt.
08/21/14
20140235768
 Flame retardant thermoplastic resin composition patent thumbnailFlame retardant thermoplastic resin composition
A polycarbonate resin composition includes (a) about 90 to about 97% by weight of a rubber-reinforced polystyrene resin, (b) about 3 to about 10% by weight of a polyphenylene ether resin, (c) about 10 to about 20 parts by weight of a halogen compound including a triazine group, or a mixture of a halogen compound including a triazine group and a diphenyl ethane bromide compound based on about 100 parts by weight of a base resin comprising (a) and (b), and (d) about 0.01 to about 3 parts by weight of an antimony compound based on about 100 parts by weight of the base resin comprising (a) and (b). The composition can exhibit excellent flame retardancy, colorability and injection molding thermal stability..
08/21/14
20140235721
 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid patent thumbnailAqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid
An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. Since even in the case where a preservative is incorporated into said aqueous liquid preparation, the preservative exhibits a sufficient preservative effect for a long time, said aqueous liquid preparation in the form of an eye drop is useful for the treatment of blepharitis, conjunctivitis, scleritis, and postoperative inflammation.
08/21/14
20140235590
 Pharmaceutical compounds for use in the therapy of clostridium difficile infection patent thumbnailPharmaceutical compounds for use in the therapy of clostridium difficile infection
The invention relates to a compound described by a general formula (1), wherein each x independently can be opo32−, opso22− or oso3−; r1 comprises a solubility function such as a polyethylene glycol moiety and each x independently can be opo32−, opso22−, − or oso3−; and z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms. The invention further relates to polysulfate derivatives or mixed polyphosphate/sulphate derivatives of six-membered cyclic polyols for use in the therapy of infection by clostridium difficile..
08/21/14
20140235553
 Compositions and methods for introduction of macromolecules into cells patent thumbnailCompositions and methods for introduction of macromolecules into cells
Disclosed are novel compositions and methods for introduction of macromolecules and nanoparticles into living cells. The invention includes a polypeptide sequence which when fused to a macromolecule or nanoparticle enhances its introduction into the cell..
08/21/14
20140235549
 Stabilized polypeptides as regulators of rab gtpase function patent thumbnailStabilized polypeptides as regulators of rab gtpase function
The present invention provides inventive polypeptides comprising a c terminal rab binding domain (rabbd) of rab family interacting proteins (fips) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating rab function comprising contacting an inventive stapled polypeptide with a rab protein, and methods of treatment associated with modulation of rab activity.
08/21/14
20140235538
Stabilized insulin-like growth factor polypeptides
The invention relates to stabilized polypeptides having an igf-1 or igf-2 sequence and an e-peptide sequence, where the natural physiological cleavage of the e-peptide from the igf is prevented.. .
08/21/14
20140235535
Engineered polypeptides having enhanced duration of action with reduced immunogenicity
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration, and reduced immunogenicity. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides.
08/21/14
20140235499
Assay for inhibitors of cip/kip protein degradation
An assay and system compatible with high throughput screening (hts) that is capable of identifying inhibitors, such as small-molecule inhibitors, of the degradation of the cdk inhibitor p21, are described. The assay is based on the use of fusion protein comprising (i) a p2 polypeptide; and (i) a reporter protein linked to the c-terminal of said p21 polypeptide, wherein the fusion protein has a half-life that is similar to that of the p21 polypeptide.
08/21/14
20140235482
Immunoglobulin fc polypeptides
Methods and compositions involving polypeptides having an aglycosylated antibody fc domain. In certain embodiments, polypeptides have an aglycosylated fc domain that contains one or more substitutions compared to a native fc domain.
08/21/14
20140235467
Protease-resistant systems for polypeptide display and methods of making and using thereof
The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.. .
08/21/14
20140235126
Resin composition, prepreg and their uses
A vinyl-compound-based resin composition containing a terminal vinyl compound (a) of a bifunctional phenylene ether oligomer having a polyphenylene ether skeleton, a specific maleimide compound (b), a naphthol aralkyl type cyanate ester resin (c) and a naphthalene-skeleton-modified novolak type epoxy resin (d) for a high-multilayer and high-frequency printed wiring board, which resin composition is excellent in varnish shelf life at low temperature and does not show a decrease in multilayer moldability, heat resistance after moisture absorption, electrical characteristics and peel strength even in a winter period and for a long period of time, and a prepreg, a metal-foil-clad laminate and a resin sheet each of which uses the above resin composition.. .
08/21/14
20140235124
Aqueous adhesive composition based on polyaldehyde and polyphenol
An aqueous adhesive composition includes: a phenol/aldehyde resin; and an unsaturated elastomer latex. The phenol/aldehyde resin is based on: an aromatic polyaldehyde bearing at least two aldehyde functional groups and including at least one aromatic nucleus; and a polyphenol including at least one aromatic nucleus.
08/21/14
20140234976
Compositions and methods for conferring herbicide resistance
The present invention provides a protein, specifically parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism.
08/21/14
20140234969
Methods for enhancing genome stability and telomere elongation in embryonic stem cells
The disclosure provides methods for increasing genome stability of an embryonic stem (es) cell or induced pluripotent stem (ips) cell, increasing telomere length in an es or ips cell, or both, for example by contacting an es or ips cell with an agent that increases expression of zscan4 in the cell. Methods for increasing genome stability or increasing telomere length in a population of es or ips cells are provided, for example by selecting zscan4+ es or ips cells from the population of es or ips cells (which can include both zscan4+ and zscan4− es or ips cells).
08/21/14
20140234962
Ligands modified by circular permutation as agonists and antagonists
The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof..
08/21/14
20140234943
Viruses lacking epithelial cell receptor entry
The document provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The document also provides methods for using viruses to treat cancer patients.
08/21/14
20140234924
Variants of glycerol dehydrogenase having d-lactate dehydrogenase activity and uses thereof
The present invention provides methods of designing and generating glycerol dehydrogenase (glydh) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding glydh polypeptide variants having altered function as compared to the parent polypeptide.
08/21/14
20140234921
Novel cutinases, their production and uses
The present invention relates to novel polypeptides, or fragments of polypeptides, genes encoding them and means for producing said polypeptides. In detail the invention relates to polypeptides having esterase, suberinase and/or cutinase activity at low ph.
08/21/14
20140234918
Polypeptides having peroxygenase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/21/14
20140234907
Polypeptides having endoglucanase activity and polynucleotides encoding same
Provided are isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/21/14
20140234903
Biosynthetic gene cluster for the production of peptide/protein analogues
A novel gene cluster encoding polypeptides involved in the generation of bio synthetically unique peptide-based compounds is described. In addition, new methods for biosynthetic engineering and production of modified peptides and proteins are disclosed.
08/21/14
20140234898
Protein and peptide libraries
Provided herein are, inter alia, methods for linking an mrna molecule to a polypeptide (e.g., a peptide or a protein) by linking the mrna molecule to a linking amino acid in the polypeptide, or by linking the mrna molecule to a linking trna to which the polypeptide is attached, via reactions not catalyzed by the ribosome, and methods for making polypeptide libraries. Also provided are mrna-protein complexes and mrna-trna-protein complexes, libraries containing these complexes, and methods of using these complexes..
08/21/14
20140234897
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Disclosed are isolated polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. Furthermore, nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains are disclosed..
08/21/14
20140234893
Heterologous intron within an immunoglobulin domain
The invention concerns the field of recombinant gene engineering. It concerns novel introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes with heterologous introns, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel intron sequences as heterologous introns..
08/21/14
20140234841
Compositions, methods and kits to detect dicer gene mutations
In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a dicer1 polypeptide.. .
08/21/14
20140234645
Reaction product of propylene polymer and wax, graft copolymers derived from polypropylene polymer and wax, hot melt adhesive compositions including the same, and methods of using and making the same
A reaction product and hot melt adhesive compositions that include the reaction product are disclosed. The reaction product includes the reaction product of a first polymer that includes at least one of polypropylene homopolymer and polypropylene-alpha-olefin copolymer, a first wax that includes at least one of polyethylene wax, fischer tropsch wax and paraffin wax, and a free radical initiator and has a viscosity of no greater than 12,000 centipoise at 177° c..
08/21/14
20140234644
Reaction product of propylene polymer and wax, graft copolymers derived from polypropylene polymer and wax, hot melt adhesive compositions including the same, and methods of using and making the same
A reaction product and hot melt adhesive compositions that include the reaction product are disclosed. The reaction product includes the reaction product of a first polymer that includes at least one of polypropylene homopolymer and polypropylene-alpha-olefin copolymer, a first wax that includes at least one of polyethylene wax, fischer tropsch wax and paraffin wax, and a free radical initiator and has a viscosity of no greater than 12,000 centipoise at 177° c..
08/21/14
20140234619
Poly(arylene ether) composition and articles derived therefrom
A composition useful for forming wire and cable insulation includes particular amounts of a poly(arylene ether), a hydrogenated block copolymer of an alkenyl aromatic compound and a conjugated diene, a polyolefin, and a flame retardant. The flame retardant includes specific amounts of zinc borate, melamine cyanurate, and an organophosphate ester.
08/21/14
20140234533
Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
08/21/14
20140234510
Palatable beverages and compositions with cocoa extract
The present subject matter relates to palatable beverages and compositions such as non-chocolate flavored water soluble dry powder compositions comprising a cocoa extract which comprises cocoa polyphenols, and an edible acid. The present subject matter further relates to processes for formulating said beverages and compositions..
08/21/14
20140234476
Preparation and incorporation of co-products into beverages to achieve metabolic and gut health benefits
Co-products from juice extraction, in particular for use in beverage and food products to enhance the metabolic and gut health benefits, including an enhanced feeling of satiety, a reduction of postprandial glucose response, reduction of postprandial insulin response, an increased fermentability by colonic microlfora, an increase short-chain fatty acid production in the colon provided to the consumer are provided. The co-product has a number average particle size of between 1 and 2000 microns, a total polyphenol content of at least 2500 parts per million, a moisture content of between 70% and 85% by weight, and a combined peel and seed content between 0.01% and 20% by weight..
08/21/14
20140234375
Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
Provided herein are cells, vectors and viruses in association with a mutant polypeptide that has emerged in response to a therapeutic or prophylactic agent; compositions comprising such cells, vectors and viruses and methods for their use in eliciting an immune response to the mutant polypeptide. In some examples, the immune response is a cellular immune response..
08/21/14
20140234365
2-hydroxyhippuric acid analogs, and methods for their synthesis and use
The present invention relates to novel 2-hydroxyhippuric acid analogs, and methods for their synthesis and use. Such analogs are designed to provide a protected or functional moiety such as a free thiol (—sh) group or a protected thiol group, thereby providing a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label..
08/21/14
20140234363
Polypeptides from non-typeable haemophilus influenzae
Polypeptides comprising non-typeable haemophilus influenzae (nthi) amino acid sequences. Over 2500 specific nthi proteins are disclosed.
08/21/14
20140234352
B7-h3 and b7-h4, novel immunoregulatory molecules
The invention provides novel b7-h3 and b7-h4 polypeptides useful for co-stimulating t cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides..
08/21/14
20140234332
Novel hiv-2 isolate
The invention provides a novel strain of hiv-2 capable of causing immunodeficiency. The invention also provides compositions comprising the nucleic acids and polypeptides characteristic of this hiv-2 virus, antibodies specific for this hiv-2 virus, methods of using these compositions, and methods of detecting hiv-2 virus..
08/21/14
20140234313
Soluble polypeptides
The invention relates generally to polypeptides, such as antibody molecules, that demonstrate high stability and solubility. In particular, the invention relates to polypeptides comprising paired vl and vh domains that demonstrate soluble expression and folding in a reducing or intracellular environment.
08/21/14
20140234311
Albumin variants
The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin..
08/21/14
20140234290
Modified factor x polypeptides and uses thereof
Modified therapeutic proteins are provided. In particular modified factor x polypeptides, which includes the factor x zymogen, factor xa and other forms of factor x, and uses thereof are provided..
08/21/14
20140234288
Lysosomal acid lipase therapy for nafld and related diseases
The present invention comprises methods and compositions for the treatment or alleviation of nafld (non-alcoholic fatty liver disease) and those conditions associated with nafld, including fatty liver disease, nonalcoholic steatohepatitis (nash) and cirrhosis through the use of pharmaceutical formulations of lysosomal acid lipase or related proteins and/or polypeptides. This invention is also directed to a combination therapy treatment for treating the metabolic syndrome.


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This listing is a sample listing of patent applications related to Polyp for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Polyp with additional patents listed. Browse our RSS directory or Search for other possible listings.
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