|| List of recent Polyp-related patents
| Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same|
Provided are methods of increasing tolerance of a plant to abiotic stress, and/or increasing biomass, growth rate, vigor and/or yield of a plant. The methods are effected by expressing within the plant an exogenous polynucleotide encoding a polypeptide comprising an amino acid sequence at least 90% homologous to the amino acid sequence selected from the group consisting of seq id nos:201, 207, 212, 202-206, 208-211, 213-391, 1655, 961-1529, and 1660-1663.
| Plants having enhanced yield-related traits and producing methods thereof|
Provided is a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a tlp (tify like protein) polypeptide, a pmp22 polypeptide (22 kda peroxisomal membrane like polypeptide), a rtf (rem-like transcription factor) polypeptide, or a bp1 (bigger plant 1) polypeptide. Also provided are plants having modulated expression of a nucleic acid encoding a tlp, pmp22, rtf or bp1 polypeptide, which plants have enhanced yield-related traits compared to control plants..
| Drought tolerant plants and related constructs and methods involving genes encoding zinc-finger (c3hc4-type ring finger) family polypeptides|
Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a zinc-finger (c3hc4-type ring finger) family polypeptide..
| Use of aldh7 for improved stress tolerance|
The present invention relates to the field of plant molecular biology, more particularly to the regulation of genes that increase drought tolerance and yield. Provided herein are methods finding use in agriculture for increasing drought tolerance in dicot and monocot plants.
| Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription|
The present disclosure provides a dna-targeting rna that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target dna and/or a polypeptide associated with the target dna. The present disclosure further provides site-specific modifying polypeptides.
| Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency|
The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention provides compositions and methods for the treatment and prevention of diseases and disorders associated with cobalamin deficiency, including compositions and methods that promote cobalamin uptake.
| Immobilized bioactive hydrogel matrices as surface coatings|
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate..
| Process for the preparation of aromatic azole compounds|
Aromatic azole compounds such as 2-(4-aminophenyl)-5-amino-benzimidazole are prepared in an organic sulfonic acid solvent instead of polyphosphoric acid. This allows recovery and recycle of the solvent and avoids the handling and environmental concerns resulting from the use of polyphosphoric acid.
| Organic light emitting host materials|
Polyphenylene compounds such as compounds represented by formulas 1-28 may be used in electronic devices such as organic light-emitting devices. For example, the compounds may be used as host material in an emissive layer..
| Peptides for treatment and diagnosis of bone diseases|
The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition.
| Alphabody libraries and methods for producing the same|
The invention provides single-chain alphabody library comprising at least 100 different-sequence single-chain alphabody polypeptides, wherein said alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the alphabody. The invention further provides methods for use of the alphabody libraries and alphabodies obtainable by the methods of the invention..
| Modified amino acids|
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis..
| Polypropylene-polylactic acid resin composition|
The provided is a polypropylene/polylactic acid resin composition comprising a polypropylene resin, a polylactic acid resin, a reactive compatibilizer, optionally an impact modifier and an inorganic filler, having excellent heat resistance, impact resistance and flexural modulus.. .
| Polypropylene-based resin composition and automobile parts using the same|
The present invention provides a polypropylene-based resin composition, which comprises of a) a polypropylene; b) an ethylene 1-octene copolymer in which r1r2<1 (herein, r1=k11/k12, r2=k22/k21, k11 is a growth reaction rate constant when ethylene is added to a growth chain in which an end active site is ethylene, k12 is a growth reaction rate constant when octene is added to a growth chain in which an end active site is ethylene, k22 is a growth reaction rate constant when octene is added to a growth chain in which an end active site is octene, and k21 is a growth reaction rate constant when ethylene is added to a growth chain in which an end active site is octene); and c) an inorganic filling agent, and a part for vehicles manufactured by using the same.. .
| Glass-filled polyamide composition and article|
A composition useful for molding electrical components is prepared by melt blending specific amounts of components including a polyamide, a poly(phenylene ether)-polysiloxane block copolymer reaction product including a poly(phenylene ether) and a poly(phenylene ether)-polysiloxane block copolymer, a flame retardant including a metal dialkylphosphinate, melamine polyphosphate, and zinc borate, and glass fibers. The use of a poly(phenylene ether)-polysiloxane block copolymer reaction product rather than a poly(phenylene ether) alone provides improved surface resistivity without sacrificing flame retardancy..
| Hydrophilic modified polyrotaxane composition|
The present invention aims to provide a hydrophilic modified polyrotaxane composition having excellent storage stability. The present invention relates to a hydrophilic modified polyrotaxane composition comprising: a hydrophilic modified polyrotaxane produced by modifying, with hydrophilic modifying groups, all or part of hydroxy groups on a cyclodextrin of a polyrotaxane containing the cyclodextrin, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a polyphenol antioxidant..
| Novel genes and proteins that home to developing microvessels|
Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to dna that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides.
| Multivalent heteromultimer scaffold design and constructs|
Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof.
| Pharmaceutical composition containing an endocytic motif and protein transduction domains for preventing or treating cancer|
The present invention relates to a novel endocytic motif, and in particular, to a fusion polypeptide including the motif represented by an amino acid sequence of seq id no. 1 and a protein transduction domain, a pharmaceutical composition for preventing or treating cancer including the same, and a method for treating cancer including the step of administering the composition.
| Simultaneous delivery of receptors and/or co-receptors for growth factor stability and activity|
The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans.
| Polypeptide conjugate|
The disclosure provides polypeptide conjugates with multiple improved pharmacological and pharmacokinetic properties and their use in treating various diseases and conditions, such as diabetes and/or obesity.. .
| Subcutaneous delivery of a long-acting natriuretic peptide|
This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided..
| Methods for using semaphorin polypeptides|
The present invention provides uses and methods of using a sema3e polypeptide and a sema3e polynucleotide encoding a sema3e polypeptide. The methods include decreasing airway remodeling in a subject, treating asthma in a subject, treating a subject having, or at risk of having, acute asthma, and reducing inflammation of a subject's airway.
| Method for the production of reading-frame-correct fragment libraries|
The present invention relates to reading-frame-correct fragment libraries, methods for their production, and the use of the fragment libraries for selection of functional polypeptide variants with improved properties.. .
| Structures of human histidyl-trna synthetase and methods of use|
Provided are histidyl-trna synthetase variant polypeptides, x-ray crystallographic and nmr spectroscopy structures of hrs polypeptides, and related compositions and methods for therapy and drug discovery.. .
| Oil absorbing material and processes of recycling absorbent articles to produce the same|
An oil absorbing material is generally provided. The oil absorbing material can includes sorbent particles having an average aspect ratio of about 5 to about 500 and a mean average particle diameter of about 10 μm to about 1 millimeter.
| Method of prognosing and diagnosing hereditary spastic paraplegia, mutant nucleic acid molecules and polypeptides|
A method for diagnosing the presence of hereditary spastic paraplegia (hsp) or predicting the risk of developing hsp in a human subject, comprising detecting the presence or absence of a defect in a gene encoding a polypeptide comprising the sequence of fig. 9 (seq id no: 19), in a nucleic acid sample of the subject, whereby the detection of the defect is indicative that the subject has or is at risk of developing hsp..
| Novel glycoside hydrolases from thermophlic fungi|
The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
| Separatome-based protein expression and purification platform|
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, such as that of e. Coli, yeast, bacillus subtilis or other prokaryotes, insect cells, mammalian cells, etc.
| Polypeptides having cellobiohydrolase activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having cellobiohydrolase activity, catalytic domains, and cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains, and cellulose binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains, or cellulose binding domains..
| Cldn5 mini-promoters|
Isolated polynucleotides comprising a cldn5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
| Method for the regulation of protein kinase activity in vivo and in vitro|
Disclosed herein is a substantially pure nucleic acid encoding a eukaryotic protein kinase having at least one mutated amino-acid residue located in its subdomain ix. Also disclosed is a substantially pure eukaryotic protein kinase polypeptide having at least one mutation in its subdomain ix, the kinase being encoded by the nucleic acid..
| Polypeptide linker and method of analyzing target material using the same|
A polypeptide linker comprising an antibody-binding region and an enzyme cleavage region, and related compositions, kits, and methods of using same.. .
| Isotopically-labeled proteome standards|
The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest.
| Isoltation of factors associated with nucleic acid|
Methods for screening and isolating peptide, polypeptide, protein complexes and non-coding nucleic acids that are associated with selected target genomic locus are provided. The methods comprise the steps of obtaining a sample that comprises a modified target genomic dna sequence and one or more peptide, polypeptide, protein complexes and non-coding nucleic acids as with that dna sequence.
| Polymer compositions and their use as cable coverings|
The present invention relates to a crosslinked polymer containing polyphenylene sulfide (pss) and an impact modifier, and its use as cable coverings, such as jacket or insulation. The composition contains a crosslinked polymer containing of polyphenylene sulfide (pps) and an impact modifier.
| Edible oils for frying and cooking foods having health benefits|
A healthy omega-7 based cooking oil for frying and cooking foods raw or prepared foods. The healthy cooking oil comprises mixture of oils having at least 30%-60% omega-7, and 70%-30% any healthy or neutral oil.
| T-cell death-inducing epitopes|
Cell death-inducing epitopes and polypeptides containing same. Also disclosed are compounds for inducing death of activated t-cells, a method of producing antibodies to the epitopes, a method of identifying compounds that bind to the epitopes, a method of inducing death of activated t-cells, and pharmaceutical compositions containing the compounds..
| Methods for treating melanoma|
Methods of inhibiting melanoma tumor growth, methods of treating melanoma and metastatic melanoma, and methods of reducing the frequency of tumor initiating cells (or cancer stem cells) in melanoma tumors are described. The methods described comprise administering a dll4 antagonist (e.g., an antibody that specifically binds the extracellular domain of human dll4) to a subject.
| Treatment for ige-mediated disease|
The invention provides an endos polypeptide, or a polynucleotide encoding an endos polypeptide, for use in a method for treating or preventing a disease or condition mediated by ige antibodies.. .
| Proteins for use in human and animal staphylococcus infections|
The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in seq id no:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors.
| Polymer conjugates of box-a of hmgb1 and box-a variants of hmgb1|
The present invention relates to novel polymer conjugates of polypeptide variants of the hmgb1 high affinity binding domain box-a (hmgb1 box-a) or of a biologically active fragment of hmgb1 box-a. Further, the invention relates to novel polymer conjugates of polypeptide variants of the hmgb1 high affinity binding domain box-a (hmgb1 box-a).