Popular terms

Polynucleotide topics
Nucleotide
Polynucleotide
Polypeptide
Antagonist
Nucleic Acid
Cancer Cell
Drug Resistance
Chromosome
Glycoprotein
Gastrointestinal
Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumor
Cellobiohydrolase
Human Disease
Inflammation

Follow us on Twitter
twitter icon@FreshPatents

Web & Computing
Cloud Computing
Ecommerce
Search patents
Smartphone patents
Social Media patents
Video patents
Website patents
Web Server
Android patents
Copyright patents
Database patents
Programming patents
Wearable Computing
Webcam patents

Web Companies
Apple patents
Google patents
Adobe patents
Ebay patents
Oracle patents
Yahoo patents

[SEARCH]

Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications.



Date/App# patent app List of recent Polynucleotide-related patents
01/28/16
20160024599 
 Compositions associated with soybean reproductive growth and methods of use patent thumbnailCompositions associated with soybean reproductive growth and methods of use
Molecular markers associated with soybean reproductive stage, methods of their use, and compositions having one or more marker loci are provided. Methods comprise detecting at least one marker locus, detecting a haplotype, and/or detecting a marker profile.
Pioneer Hi-bred International, Inc.


01/28/16
20160024590 
 Falz for use as a target for therapies to treat cancer patent thumbnailFalz for use as a target for therapies to treat cancer
The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of bptf. The disclosure also provides methods for determining whether a cancer in a subject is progressing or regressing based upon the change of expression levels of bptf between two time points.
Sutter West Bay Hospitals


01/28/16
20160024571 
 Scalable characterization of nucleic acids by parallel sequencing patent thumbnailScalable characterization of nucleic acids by parallel sequencing
A method for detecting the presence or absence of a target polynucleotide in a sample is described.. .
Affymetrix, Inc.


01/28/16
20160024562 
 Polynucleotides for the amplification and detection of chlamydia trachomatis and neisseria gonorrhoeae patent thumbnailPolynucleotides for the amplification and detection of chlamydia trachomatis and neisseria gonorrhoeae
Polynucleotides useful for detecting chlamydia trachomatis and/or neisseria gonorrhoeae in a test sample, kits, a nucleic acid amplification method and detection method including the same.. .
Abbott Molecular Inc.


01/28/16
20160024520 
 Cloning and use of the ms9 gene from maize patent thumbnailCloning and use of the ms9 gene from maize
Nucleotide sequences, amino acid sequences, and an associated promoter sequence are useful in methods of controlling male fertility in plants. Recombinant expression cassettes, vectors, plant cells, and plants comprise a disclosed nucleotide sequence and may encode a disclosed amino acid sequence.
E.i. Dupont De Nemours & Company


01/28/16
20160024517 
 Drought tolerant plants and related constructs and methods involving genes encoding self-incompatibility protein related polypeptides patent thumbnailDrought tolerant plants and related constructs and methods involving genes encoding self-incompatibility protein related polypeptides
Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes an sipr polypeptide..
Pioneer Hi-bred International Inc


01/28/16
20160024509 
 Expression vector patent thumbnailExpression vector
An expression vector for expressing a target polypeptide in a prokaryotic cell is provided. The vector comprises a promoter operably linked to a polynucleotide encoding the target polypeptide operably linked to a eukaryotic secretion leader sequence, the eukaryotic secretion leader sequence encoding a signal peptide sequence selected from the group consisting of: a) mlkrsswlatlglltvasvstivya; b) mkkatfitcllavllvsnpiwna; c) mkvsaaalaviliatalcapasa; d) mkvstaflcllltvsafsaqvla; and e) mkclllalglalacaaqa.
Fujifilm Diosynth Biotechnologies Uk Limited


01/28/16
20160024506 
 Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene patent thumbnailTreatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a lipid transport and metabolism gene, in particular, by targeting natural antisense polynucleotides of a lipid transport and metabolism gene. The invention also relates to the identification of the antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of a lipid transport and metabolism genes..
Curna, Inc.


01/28/16
20160024505 
 Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene patent thumbnailTreatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a lipid transport and metabolism gene, in particular, by targeting natural antisense polynucleotides of a lipid transport and metabolism gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of a lipid transport and metabolism genes..
Curna, Inc.


01/28/16
20160024215 
 Llt-1 antibodies with new functional properties patent thumbnailLlt-1 antibodies with new functional properties
The present invention relates to monoclonal antibodies that are capable of specifically binding to lectin-like transcript 1 (llt1), to polynucleotides encoding such antibodies, and to cells that express such antibodies. Antibodies of the invention have utility in the treatment of autoimmune diseases and cancer, in which llt1- and cd161-expressing cells play a role in disease pathogenesis..
Centre National De La Recherche Scientifique


01/28/16
20160024188 

Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof


Described are binding molecules such as human monoclonal antibodies that bind to influenza virus h5n1 and have neutralizing activity against influenza virus h5n1. Also described are polynucleotides encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies.
Crucell Holland B.v.


01/28/16
20160024181 

Long-lived polynucleotide molecules


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


01/28/16
20160024177 

Novel epitope for switching to th1 cell and use thereof


The present invention relates to a novel epitope that converts t cell to type 1 helper t (th1) cell. Specifically, the present invention relates to an epitope constituting the 56th to 65th amino acids (seq id no.2) of extracellular domain (ecd) of activation-inducible tumor necrosis factor receptor (aitr), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting t cell to th1 cell and a method for converting t cell to th1 cell, a pharmaceutical composition comprising the antibody for preventing or treating cancer, a method for treating cancer using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody..

01/28/16
20160024174 

Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen


Provided are compositions and methods for prophylaxis and/or therapy of a variety of cancers which express a ny-eso-1 antigen. Included are recombinant t cell receptors (tcrs), polynucleotides encoding them, expression vectors that include the polynucleotides, and cells into which the polynucleotides have been introduced to produce modified cells, including cd4+ t cells, cd8+ t cells, natural killer t cells, γδ t cells, and progenitor cells, such as haematopoietic stem cells.
Health Research, Inc.


01/28/16
20160022821 

Biodegradable poly (beta-amino esters) and uses thereof


Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided.
Massachusetts Institute Of Technology


01/28/16
20160022791 

Cytotoxic t lymphocyte inducing immunogens for prevention treatment and diagnosis of cancer


The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as lung carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a ctl response against lung and other cancers..
Immunotope, Inc.


01/28/16
20160022780 

Urocortin 2 analogs and uses thereof


Disclosed are polypeptides that are analogs of urocortin 2 that have pharmacological activity similar to urocortin 2 but have improved water solubility compared to urocortin 2, and pharmaceutical compositions of the polypeptides of the present invention. Also disclosed are polynucleotides encoding the polypeptides, and methods of treating pathophysiological states employing pharmaceutical compositions of the polypeptides and polynucleotides of the present invention.
Research Development Foundation


01/28/16
20160022766 

Mtor ligands and polynucleotides encoding mtor ligands


The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mtor activity.
Intrexon Corporation


01/21/16
20160017415 

Methods and kits for identifying and adjusting for bias in sequencing of polynucleotide samples


Disclosed are methods for determining one or more nucleotides at one or more nucleotide positions of a polynucleotide sample, the polynucleotide sample comprising heterogeneous polynucleotides having different nucleotides at the nucleotide positions. The disclosed, methods may be utilized to control for sequencing bias during sequencing of the polynucleotide sample.
Mdxhealth, Inc.


01/21/16
20160017396 

Polynucleotide enrichment using crispr-cas systems


A method for enriching a target nucleic acid comprising providing an endonuclease system having a crrna or a derivative thereof, and a cas protein or a variant thereof. The crrna or the derivative thereof contains a target-specific nucleotide region substantially complementary to a region of the target nucleic acid; contacting the target nucleic acid with the endonuclease system to form a complex; and separating the complex and thereby enriching for the target nucleic acid..
Illumina, Inc.


01/21/16
20160017365 

Manipulation of dominant male sterility


Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and active fragments and variants thereof, which modulate male fertility.
Pioneer Hi-bred International, Inc.


01/21/16
20160017363 

Toxin genes and methods for their use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
Bayer Cropscience Lp


01/21/16
20160017361 

Plants with altered root architecture, related constructs and methods involving genes encoding exostosin family polypeptides and homologs thereof


Isolated polynucleotides and polypeptides and recombinant dna constructs particularly useful for altering root structure of plants, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter functional in a plant, wherein said polynucleotide encodes a polypeptide useful for altering plant root architecture..
Pioneer Hi-bred International Inc


01/21/16
20160017357 

Polynucleotides and methods for improving plants


The invention provides methods and compositions for producing plant with altered biomass, the methods comprising the step of altering the expression and/or activity of the polypeptide comprising the sequence of seq id no:1, or a variant thereof, in a plant cell or plant. The invention also provides a polypeptide comprising the sequence of seq id no:1, and fragments of variants thereof the sequence.
Fonterra Co-operative Group Limited


01/21/16
20160017356 

Transcription factors


The invention provides polynucleotide sequences isolated from plants encoding transcription factors. Polypeptides encoded by the polynucleotides are also provided.
Arborgen Inc.


01/21/16
20160017355 

Tissue specific reduction of lignin


The present invention provides an expression cassette comprising a polynucleotide that encodes a protein that diverts a monolignol precursor from a lignin biosynthesis pathway in the plant, which is operably linked to a heterologous promoter. Also provided are methods of engineering a plant having reduced lignin content, as well as plant cells, plant parts, and plant tissues from such engineered plants..
The Regents Of The University Of California


01/21/16
20160017351 

Methods and compositions for targeting sequences of interest to the chloroplast


Chimeric polynucleotides comprising a nucleotide sequence encoding a chloroplast transit peptide operably linked to a heterologous polynucleotide of interest are provided, wherein the chloroplast transit peptide comprises an amino acid sequence having the chloroplast transit peptide sequence as set forth in seq id no: 1 or a biologically active variant or fragment thereof or wherein the chloroplast transit peptide comprises the sequence set forth in seq id no: 58 or an active variant or fragment thereof. Chimeric polypeptides encoding the same, as well as, cells, plant cells, plants and seeds are further provided which comprise the chimeric polynucleotides.
Pioneer Hi-bred International, Inc.


01/21/16
20160017350 

Compositions and methods of use of acc oxidase polynucleotides and polypeptides


Transgenic compositions and methods reduce the expression of endogenous acc oxidase genes to improve an agronomic characteristic of a crop plant, which may be maize. Yield increase and drought tolerance due to reduction in the endogenous acc oxidase levels are observed.
Pioneer Hi-bred International, Inc.


01/21/16
20160017349 

Maize microrna sequences and targets thereof for agronomic traits


Methods and compositions for maize target gene suppression and improving an agronomic trait through micrornas or target gene modulation are disclosed. polynucleotide constructs useful for gene silencing, or upregulation or modulation as well as cells, plants and seeds comprising the polynucleotides and methods for using micrornas to silence a target gene are also described..
Pioneer Hi-bred International, Inc.


01/21/16
20160017347 

Terminating flower (tmf) gene and methods of use


Described herein are the following: isolated polynucleotides, isolated polypeptides and recombinant dna constructs; compositions (such as plants or seeds) comprising these recombinant dna constructs; and methods of use for these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a tmf polypeptide..
Cold Spring Harbor Laboratory


01/21/16
20160017346 

Soybean agb1 promoter and its use in tissue-specific expression of transgenic genes in plants


The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean predicted allergen gly m bd 28k peptide gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a tissue-specific manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E.i. Du Pont De Nemours And Company


01/21/16
20160017343 

Host cells and methods of use


The present invention relates to genetically modified host cells, in particular yeast cells, comprising at least one isolated polynucleotide encoding a killer expression protease (kex2p) or a fragment and/or variant thereof which has at least one kex2p functional activity and at least one isolated polynucleotide encoding a protein disulfide-isomerase (pdi1) or a fragment and/or variant thereof which has at least one pdi functional activity. Also provided herein are genetically modified host cells comprising at least one isolated polynucleotide encoding a killer expression protease (kex2p) or a fragment and/or variant thereof which has at least one kex2p functional activity, at least one isolated polynucleotide encoding a protein disulfide-isomerase (pdi1) or a fragment and/or variant thereof which has at least one pdi1 functional activity and at least one isolated polynucleotide encoding a endoplasmic reticulum oxidoreductin (ero1) or a fragment and/or variant thereof which has at least one ero1 functional activity..
Glaxosmithkline Llc


01/21/16
20160017311 

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases


Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited


01/21/16
20160017306 

Methods for using polypeptides having cellobiohydrolase activity


The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


01/21/16
20160017296 

Dehydrogenase variants and polynucleotides encoding same


The present invention relates to 3-hydroxypropionate dehydrogenase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


01/21/16
20160017047 

Cd20-binding immunotoxins for inducing cellular internalization and methods using same


The present invention provides cd20-binding proteins that bind to and rapidly internalize cd20 antigens from a cell surface location to the interior of a cell. Cd20-binding proteins of the invention comprise a cd20 binding region and a shiga toxin effector region.
Molecular Templates, Inc.


01/21/16
20160017021 

Tnf alpha inhibitor polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same


A plant produced tnf alpha polypeptide inhibitor is provided. Also provided are methods of generating and using same..
Protalix Ltd.


01/21/16
20160017020 

Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same


(ii) a second domain which comprises an fc domain of an immunoglobulin, wherein the first domain and the second domain are n-terminally to c-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds tnf alpha.. .

01/21/16
20160017013 

Use of mutant haptoglobin having angiogenesis promoting activity


The present invention relates to a use of mutant haptoglobin having angiogenesis-promoting activity and, more particularly, to a mutant haptoglobin polypeptide, a recombinant vector containing a polynucleotide encoding the polypeptide, or a composition for promoting angiogenesis containing, as an active ingredient, a transformant transformed with the recombinant vector. The mutant haptoglobin according to the present invention includes an amino acid sequence of seq id no: 1 in which the 143rd amino acid is substituted with an amino acid other than arg.
Catholic University Industry Academic Cooperation Foundation


01/21/16
20160015062 

Feline bitter taste receptors and methods


A family of novel feline bitter taste receptors, referred to as feline tas2r (ftas2r), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors.
Applied Food Biotechnology, Inc.


01/14/16
20160011173 

Method of screening a drug such as insulin secretagogue


The screening method of the present invention is useful for screening drugs such as insulin secretagogues having an insulin secretagogue activity with minimized side effects (hypoglycemia induction, etc.). The transformant in which a polynucleotide encoding the fusion protein used for the screening method is introduced, the screening kit comprising the transformant, etc.
Jnc Corporation


01/14/16
20160010147 

Enzyme stalling method


The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases..
Oxford Nanopore Technologies Limited


01/14/16
20160010132 

Pentose fermentation by a recombinant microorganism


The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.. .
Codexis, Inc.


01/14/16
20160010092 

Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of tristetraproline (ttp), in particular, by targeting natural antisense polynucleotides of tristetraproline (ttp). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of ttp..
Curna, Inc.


01/14/16
20160010075 

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases


Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited


01/14/16
20160010068 

Fusion polynucleotides and fusion polypeptides associated with cancer and particularly melanoma and their uses as therapeutic and diagnostic targets


Novel fusion molecules and uses are disclosed.. .

01/14/16
20160010038 

Polypeptides with lipase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides with lipase activity, selected from the group consisting of: (a) a polypeptide having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to seq id no: 4; (b) a polypeptide encoded by a polynucleotide that hybridizes under low stringency conditions, medium stringency conditions, medium-high stringency conditions, high stringency conditions, or very high stringency conditions with (i) seq id no: 3 or the full-length complement of (i); (c) a polypeptide encoded by a polynucleotide having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to seq id no: 3; (d) a polypeptide which is a variant of seq id no: 4 comprising a substitution, deletion, and/or insertion at one or more (e.g. Several) positions; and (e) a polypeptide which is a fragment of any of the polypeptides of (a), (b), (c) or (d).
Novozymes A/s


01/14/16
20160009784 

Chimeric receptors with 4-1bb stimulatory signaling domain


The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1bb signaling domain.
St. Jude Children's Research Hospital, Inc.


01/14/16
20160009781 

Antigen-specific helper t-cell receptor genes


The present invention pertains to polynucleotides that encode cdr3 in tcr-[alpha] and tcr-[beta] chain genes of cd4+ helper t-cells that are specific to wt1 helper peptides having an amino acid sequence represented by seq id no: 123. The present invention further pertains to the peptides encoded by said polynucleotides.
International Institute Of Cancer Immunology, Inc.


01/14/16
20160009771 

Novel polypeptide exhibiting fluorescent properties and use thereof


In order to provide a novel fluorescent protein and use thereof, the polypeptide according to the present invention has fluorescent properties in the presence of bilirubin and includes (1) the amino acid sequence of seq id no: 1, (2) an amino acid sequence having, for example, substitution of 1 to 21 amine acids in the amino acid sequence of seq id no: 1, (3) an amino acid sequence having 85% or more sequence identity to the amino acid sequence of seq id no: 1, or (4) the amino acid sequence encoded by a polynucleotide that hybridizes with a polynucleotide consisting of a sequence complementary to the polynucleotide encoding the polypeptide according to the amino acid sequence in (1) under a stringent condition.. .
Riken


01/14/16
20160009657 

Amine-containing lipids and uses thereof


Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided.
Massachusetts Institute Of Technology


01/14/16
20160008445 

Kntc2 peptides and vaccines containing the same


Peptide vaccines against cancer are described herein. In particular, isolated epitope peptides derived from the kntc2 gene that elicit ctls and thus are suitable for use in the context of cancer immunotherapy are provided.
Oncotherapy Science, Inc.


01/07/16
20160004814 

Methods and compositions related to regulation of nucleic acids


Described herein are methods and compositions for analyzing regulatory regions within polynucleotides, particularly within genomic dna. The methods provided herein include cleaving the polynucleotides with a cleaving agent such as dnase1 and using the cleavage patterns for such applications as identifying regulatory states of a cellular or polynucleotide sample; identifying novel regulatory elements; generating maps of binding patterns of regulatory factors along a polynucleotide; generating maps of regulatory networks; and identifying topologic features of a polynucleotide sample, particularly samples of polynucleotides bound to proteins.
University Of Washington Through Its Center For Commercialization


01/07/16
20160003852 

Feline bitter taste receptors and methods


A family of novel feline bitter taste receptors, referred to as feline tas2r (ftas2r), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors.
Applied Food Biotechnology, Inc.


01/07/16
20160003819 

Rapid tests for insurance underwriting


The present invention relates to rapid test devices, kits and systems comprising the rapid test devices for assessing at least two analytes in a sample derived from a life or health insurance applicant, said at least two analytes being selected from the group consisting of a human immunodeficiency virus (hiv) antigen (e.g., a hiv polypeptide), a hiv polynucleotide, an anti-hiv antibody, a hepatitis c virus (hcv) antigen (e.g., a hcv polypeptide), a hcv polynucleotide, an anti-hcv antibody, a liver enzyme alanine transaminase (alt), a liver enzyme aspartate transaminase (ast), nt-probnp (or nt-probnp), probnp (or probnp), cotinine, nicotine, cocaine, a metabolite of cocaine (e.g., benzoylecgonine), pro state-specific antigen (psa), apolipoprotein a-1 (apoa1), apolipoprotein b (apob), hemoglobin ale and high-sensitivity c-reactive protein (hscrp). The present invention also relates to methods for using the rapid test devices, kits and systems as part of the assessment of the life or health insurance applications..
Force Diagnostics, Inc.


01/07/16
20160002742 

Maize event hcem485, compositions and methods for detecting and use thereof


Maize event hcem485 is provided, in which plants comprising the event are tolerant to exposure to a glyphosate herbicide. Maize genomic polynucleotides flanking the insert dna providing glyphosate tolerance are provided.
Stine Seed Farm Inc.


01/07/16
20160002727 

Novel androgen receptor mutation


Compositions and methods are provided for diagnosis, prognosis and treatment of ar-related diseases, such as prostate diseases, such as prostate cancer, breast cancer, and many other diseases. In particular, a novel and clinically relevant mutation at position 876 of the androgen receptor (ar) has been identified.
Novartis Ag


01/07/16
20160002716 

Novel ligase activity


Compositions and methods are provided for ligating polynucleotides having a length that is greater than 8 nucleotides on an rna splint. The ligation reaction provides consistent results in high or low atp concentrations.
New England Biolabs, Inc.


01/07/16
20160002688 

Engineered transaminase polypeptides for industrial biocatalysis


The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds..
Codexis, Inc.


01/07/16
20160002683 

Polypeptides having peroxygenase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


01/07/16
20160002658 

Compositions and methods to enhance mechanical stalk strength in plants


Isolated polynucleotides and polypeptides and recombinant dna constructs useful for enhancing mechanical stalk strength in plants, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ctl1 polypeptide..
Pioneer Hi-bred International, Inc.


01/07/16
20160002656 

Identification and use of krp mutants in wheat


The invention provides a wheat cell, part, tissue culture or whole plant comprising at least one disrupted krp gene of the present invention. The present invention also provides methods of increasing weight, size, and/or number of one or more organs, and/or yield of a wheat plant by utilizing the disrupted krp genes of the present invention.
Targeted Growth, Inc.


01/07/16
20160002648 

Genes for improving nutrient uptake and abiotic stress tolerance in plants


The present disclosure provides methods to increase crop yield utilizing transgenic genes controlling plant growth and yield. The specific genes can be used to increase tissue growth and abiotic stress tolerance.
Pioneer Hi-bred International Inc.


01/07/16
20160002640 

Treatment of membrane bound transcription factor peptidase, site 1 (mbtps1) related diseases by inhibition of natural antisense transcript to mbtps1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of membrane bound transcription factor peptidase, site 1 (mbtps1), in particular, by targeting natural antisense polynucleotides of membrane bound transcription factor peptidase, site 1 (mbtps1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of mbtps1..
Curna, Inc.


01/07/16
20160002616 

Genes with codon mutations encoding xylanase


The present disclosure provides for a polynucleotide sequences encoding a xylanase. More specifically, the present disclosure provides for polynucleotide sequences with codon mutations encoding a xylanase..
Basf Enzymes Llc


01/07/16
20160002607 

Adeno-associated-virus rep sequences, vectors and viruses


The invention provides adeno-associated virus (aav) replication (rep) sequences. In one embodiment, the invention provides nucleotide sequences encoding a chimeric protein, wherein the encoded chimeric protein contains a wild type aav rep inhibitory amino acid sequence, and wherein the nucleotide sequences contain a scrambled and/or deoptimized polynucleotide sequence encoding the wild type aav rep inhibitory amino acid sequence.
The Research Foundation For The State University Of New York


01/07/16
20160002591 

Inactivation of glutamyl polypeptide synthesis in bacillus


The present invention relates to isolated polynucleotides of the chromosome of bacillus licheniformis sj1904 that encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing biologically active substances encoded by the polynucleotides and to methods of using the isolated polynucleotides of the complete chromosome of bacillus licheniformis sj1904.. .
Novozymes Inc.


01/07/16
20160002340 

Zcytor17 heterodimeric cytokine receptor monoclonal antibodies


Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto..
Zymogenetics, Inc.


01/07/16
20160002317 

Cytoplasmic expression of fab proteins


The present invention relates generally to antigen binding polypeptides, such as fab fragments and derivatives thereof, that demonstrate high stability and solubility. The present invention also relates to polynucleotides encoding such polypeptides, to libraries of such polypeptides or polynucleotides, and to methods of using such polypeptides in research, diagnostic and therapeutic applications.
Affinity Biosciences Of Fab Proteins


01/07/16
20160002178 

Polyamine-fatty acid derived lipidoids and uses thereof


The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of formula (i) or (ii)) and methods of preparing the lipidoids. A described lipidoid includes r—c(═o)—o— moieties (where r is a lipid moiety), which may be hydrolyzed into non-toxic fatty acids.
Massachusetts Institute Of Technology


01/07/16
20160001247 

Microarray synthesis and assembly of gene-length polynucleotides


There is disclosed a process for in vitro synthesis and assembly of long, gene-length polynucleotides based upon assembly of multiple shorter oligonucleotides synthesized in situ on a microarray platform. Specifically, there is disclosed a process for in situ synthesis of oligonucleotide fragments on a solid phase microarray platform and subsequent, “on device” assembly of larger polynucleotides composed of a plurality of shorter oligonucleotide fragments..
Gen9, Inc.


01/07/16
20160000895 

Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection


Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an apicomplexan parasite and reduce the morbidity or morality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector..
The Texas A&m University System


01/07/16
20160000876 

Il-33 and treatment of neurodegenerative diseases


The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to therapies of neurodegenerative diseases.
University Of Eastern Finland (kuopion Kampus)


12/31/15
20150377856 

Compensated patch-clamp amplifier for nanopore polynucleotide sequencing and other applications


A compensated patch-clamp system for polynucleotide sequencing and other applications.. .
The Regents Of The University Of California


12/31/15
20150376671 

Compositions and methods for inhibiting terminal transferase activity


The present invention realtes to systems and methods for amplifying nucleic acid. In particular, systems and methods are provided for inhibiting polymerase based terminal transferase activity within a polynucleotide amplification setting (e.g., polymerase chain reaction).
Ibis Biosciences, Inc.


12/31/15
20150376650 

Methods and compositions for modifying a targeted locus


Methods and compositions are provided for modifying one or more target loci in a cell. Such methods comprise providing a cell comprising a first polynucleotide encoding a first selection marker operably linked to a first promoter active in the cell, wherein the first polynucleotide further comprises a first recognition site for a first nuclease agent.
Regeneron Pharmaceuticals, Inc.


12/31/15
20150376648 

In vivo production of proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


12/31/15
20150376642 

Transgenic plant with increased stress tolerance and yield


Polynucleotides are disclosed which are capable of enhancing growth, yield under water-limited conditions, and/or increased tolerance to an environmental stress of a plant transformed to contain such polynucleotides. Also provided are methods of using such polynucleotides and transgenic plants and agricultural products, including seeds, containing such polynucleotides as transgenes..
Basf Plant Science Gmbh


12/31/15
20150376641 

Isolated polynucleotides and polypeptides, construct and plants comprising same and methods of using same for increasing nitrogen use efficiency of plants


Provided are isolated polypeptides which are at least 80% homologous to seq id nos: 496-794, 2898-3645, and 3647-4855, isolated polynucleotides which are at least 80% identical to seq id nos: 1-495 and 795-2897, nucleic acid constructs comprising same, transgenic cells expressing same, transgenic plants expressing same and method of using same for increasing fertilizer use efficiency, nitrogen use efficiency, yield, growth rate, biomass, vigor, oil content, photosynthetic capacity, seed yield, fiber yield, fiber quality, fiber length, and/or abiotic stress tolerance of a plant.. .
Evogene Ltd.


12/31/15
20150376640 

Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency of plants


Provided are isolated polypeptides which are at least 80% homologous to seq id nos: 202-219, 221-292, 295-327, 4064-4175, 4177-4210, 4212-4580, 4582-4603, 4605-4749, 4751-4778, 4780-5223, 5225-5493, 5522-5807, 5812, 5815-5816, 5828-6679, 6689-6690, 6708-6785, 6792-6892 or 6893, isolated polynucleotides which are at least 80% identical to seq id nos: 1-91, 94-201, 328-2317, 2320-2321, 2323, 2326-3835, 3838-3840, 3842-3843, 3848, 3850-3852, 3854, 3856-3953, 3955-4061 or 4062, nucleic acid constructs comprising same, transgenic cells expressing same, transgenic plants expressing same and method of using same for increasing yield, abiotic stress tolerance, growth rate, biomass, vigor, oil content, photosynthetic capacity, seed yield, fiber yield, fiber quality, fiber length, and/or nitrogen use efficiency of a plant.. .
Evogene Ltd.


12/31/15
20150376633 

Sb-ubi terminator sequence for gene expression in plants


The present invention discloses polynucleotide sequences that can be used to regulate gene expression in plants. Terminator sequences from sorghum bicolor that are functional in plants are disclosed.
Pioneer Hi-bred International, Inc


12/31/15
20150376631 

Soybean hrp1 promoter and its use in tissue-specific expression of transgenic genes in plants


The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean hypersensitive-induced response protein gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a tissue-specific manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E.i. Du Pont De Nemours And Company


12/31/15
20150376620 

Vascular endothelial growth factor-binding aptamers


Disclosed is providing, a novel vegf-binding aptamer whose affinity to vegf is higher than those of known vegf-binding aptamers. By a in silico maturation method starting from a known vegf-binding aptamer, 4 kinds of aptamers whose affinities to vegf are higher than that of the known vegf-binding aptamer were prepared.
Jnc Corporation


12/31/15
20150376604 

Scaffolded peptidic libraries and methods of making and screening the same


Scaffolded peptidic libraries and methods of screening the same for specific binding to a target protein are provided. Each library includes distinct peptidic compounds that include a scaffold domain and a distinct variable domain.
The Governing Council Of The University Of Toronto


12/31/15
20150376602 

Compositions and methods for multiplex nucleic acids synthesis


Aspects of the invention relate to methods, compositions for designing and producing a target nucleic acid. In particular, aspects of the invention relate to the multiplex synthesis of target polynucleotides..
Gen9, Inc.


12/31/15
20150376592 

Process for making recombinant antidote to factor xa inhibitor


Disclosed are methods and isolated cells useful for the improved production of function fxa derivative protein that acts as a fxa inhibitor antidote. One aspect relates to an isolated cell comprising the r-antidote polynucleotide and furin polynucleotide.
Portola Pharmaceuticals, Inc.


12/31/15
20150376244 

Axmi115 variant insecticidal gene and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be used in dna constructs or expression cassettes for expression in plants and bacteria.
Athenix Corp.


12/31/15
20150376144 

Stereochemically enriched compositions for delivery of nucleic acids


A pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of a pharmaceutically acceptable salt thereof, the composition characterized in that greater than a first threshold amount of the total amount of chemical entities of formula i in the composition: are chemical entities of formula i.a, wherein the first threshold amount is 50%; or are chemical entities of formula i.b.1, wherein the first threshold amount is 25%; or are chemical entities of formula i.b.2, wherein the first threshold amount is 25%, wherein the chemical entities of formula i.a, i.b.1, and i.b.2, are described herein, and methods of using such compositions, for example, for the delivery of a polynucleotide in vivo.. .

12/24/15
20150369740 

Optogenetic probes for measuring membrane potential


Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants..
The Governors Of The University Of Alberta


12/24/15
20150368708 

Systems and methods to detect rare mutations and copy number variation


The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference.
Gaurdant Health, Inc.


12/24/15
20150368683 

Polypeptides having endoglucanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


12/24/15
20150368665 

Modified polynucleotides for the production of secreted proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


12/24/15
20150368644 

Treatment of interferon-related developmental regulator 1 (ifrd1) related diseases by inhibition of natural antisense transcript to ifrd1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of interferon-related tested developmental regulator 1 (ifrd1), in particular, by targeting natural antisense polynucleotides of interferon-related developmental regulator 1 (ifrd1). The invention also relates to the identification of these antisense oligonucleotides and their use in framing diseases and disorders associated with the expression of ifrd1..
Curna, Inc.


12/24/15
20150368629 

Polypeptides having cellobiohydrolase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


12/24/15
20150368627 

Polypeptides having phospholipase c activity and polynucleotides encoding same


Provided are isolated polypeptides having phospholipase c activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


12/24/15
20150368622 

Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization


Described herein are rsv polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against rsv..
The United Of America, As Represented By Secretary, Department Of Health And Human Services


12/24/15
20150368611 

Induced regulatory t cell and use thereof


The present invention relates to a transduced t cell precursor prepared by introducing a gene construct comprising a polynucleotide encoding c/ebp (ccaat/enhancer binding protein) to a t cell precursor and overexpressing the c/ebp thereby, wherein the transduced t cell precursor is capable of differentiating into a regulatory t cell and an induced regulatory t cell differentiated therefrom. The transduced t cell precursor and the induced regulatory t cell may be useful for preventing and treating autoimmune diseases, inflammatory diseases and graft rejections caused by the malfunction of immune response..
Seoul National University R&db Foundation


12/24/15
20150368338 

Interferon alpha and omega antibody antagonists


The present invention relates to antibodies that broady neutralize interferon-α and interferon-ω, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.. .
Janssen Biotech, Inc.


12/24/15
20150368307 

Lentiviral vector based immunological compounds against malaria


The invention relates to lentiviral vector particles pseudotyped with a determined heterologous viral envelope protein or viral envelope proteins originating from a rna virus and which comprise in its genome at least one recombinant polynucleotide encoding at least one polypeptide(s) carrying epitope(s) of an antigen of a plasmodium parasite capable of infecting a mammalian host. The lentiviral vector particles are used in order to elicit an immunological response against malaria parasites..

12/24/15
20150368305 

Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
Athenix Corp.


12/24/15
20150366958 

Treatment and prevention of malaria


The present invention relates to recombinant fragments of plasmodium polypeptides and polynucleotides encoding same. The invention further relates to compositions comprising the recombinant fragments of plasmodium polypeptides and their use in the treatment and prevention of malaria..

12/24/15
20150366211 

Vegetative insecticidal proteins useful for control of insect pests


Dig-657 vegetative insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed. The invention includes dig-657 variants, fragments and analogs..
Dow Agrosciences Llc




Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

Follow us on Twitter
twitter icon@FreshPatents

###

This listing is a sample listing of patent applications related to Polynucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Polynucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.


1.8647

5100

0 - 1 - 102