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Polynucleotide patents

      

This page is updated frequently with new Polynucleotide-related patent applications.




 High-throughput single-cell analysis combining proteomic and genomic information patent thumbnailnew patent High-throughput single-cell analysis combining proteomic and genomic information
Disclosed herein are methods for single-cell sequencing. In some examples, the methods include enriching a sample comprising a plurality of cells for cells of interest to produce an enriched cell sample; isolating one or more cells of interest in the enriched cell sample; and obtaining sequence information of one or more polynucleotides from each of the one or more isolated cells.
Becton, Dickinson And Company


 Synthetic long read dna sequencing patent thumbnailnew patent Synthetic long read dna sequencing
The disclosure describes a method for sequencing long portions of dna sequence by assembling a plurality of shorter polynucleotide reads. Generally, the method includes annealing a plurality of primers to a denatured dna molecule, appending a barcode polynucleotide to the 5′ end of the primer, subjecting the dna molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5′ end of the primer, sequencing the barcode polynucleotides and the genomic dna, and assembling the short read polynucleotide sequences having identical barcode polynucleotides..
Stc.unm


 Antibody libraries patent thumbnailnew patent Antibody libraries
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.. .
Adimab, Llc


 Regulated pepc expression patent thumbnailnew patent Regulated pepc expression
The present invention relates to a recombinant fungal host cell comprising at least one first polynucleotide encoding a polypeptide of interest; and one or more second polynucleotide encoding a fungal pepc protease, wherein the one or more second polynucleotide is operably linked to a regulated heterologous promoter, as well as a method for producing a polypeptide of interest, comprising cultivating said fungal host cell.. .
Novozymes A/s


 Novel glycoside hydrolases from thermophlic fungi patent thumbnailnew patent Novel glycoside hydrolases from thermophlic fungi
The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


 Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof patent thumbnailnew patent Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof
The invention relates to the cloning, sequencing and characterization of the gene responsible for quorum quenching (qq) activity against quorum sensing (qs) signals of the tenacibaculum sp. Strain 20j (cect7426).
FundaciÓn Pedro BarriÉ De La Maza, Conde De Fenosa


 Polypeptides having glucuronyl esterase activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having glucuronyl esterase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having glucuronyl esterase activity, catalytic domains and polynucleotides encoding the polypeptides or catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains..
Novoyzmes A/s


 Polypeptides having peroxygenase activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having peroxygenase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


 Antibody therapeutics that bind cd137 patent thumbnailnew patent Antibody therapeutics that bind cd137
There is disclosed compositions and methods relating to or derived from anti-cd137 antibodies. More specifically, there is disclosed fully human antibodies that bind cd137, cd137-antibody binding fragments and derivatives of such antibodies, and cd137-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


 Use of endostatin peptides for the treatment of fibrosis patent thumbnailnew patent Use of endostatin peptides for the treatment of fibrosis
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and polynucleotides are disclosed.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


new patent

Novel epitope for switching to th17 cell and use thereof


The present invention relates to a novel epitope to convert t cell to type 17 helper t (th17) cell. Specifically, the present invention relates to an epitope constituting the 41st to 50th amino acids (seq id no.
National Cancer Center


new patent

Polynucleotides encoding immune modulating polypeptides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.. .
Moderna Therapeutics, Inc.


new patent

Polynucleotides encoding low density lipoprotein receptor


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an ldlr signally enhancing mutation).. .
Moderna Therapeutics, Inc.


new patent

Cholera toxin a-like polypeptide useful as adjuvant component


A cholera toxin-like polypeptide useful as adjuvant is provided. polynucleotide coding to the polypeptide and associated vectors, host cells and methods of production are provided.
Gotovax Ab


new patent

Polynucleotide compositions containing amino acids


The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.. .
Moderna Therapeutics, Inc.


new patent

Long poly(a) plasmids and methods for introduction of long poly(a) sequences into the plasmid


Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering the polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, and methods of enhancing transcription, translation, and increasing stability of a polynucleotide.. .
Seattle Children's Research Institute


new patent

Methods for treating cancers comprising k-ras mutations


Methods of inhibiting tumor growth, methods of treating cancer, and methods of reducing the frequency of cancer stem cells in a tumor are described. Particularly, the methods are directed to tumors or cancers that comprise a k-ras mutation.
Oncomed Pharmaceuticals, Inc.


new patent

Factor ix polypeptides and methods of use thereof


The present invention provides methods of administering factor ix; methods of administering chimeric and hybrid polypeptides comprising factor ix; chimeric and hybrid polypeptides comprising factor ix; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.. .
Biogen Hemophilia Inc.


Non-ribosomal protein synthesis pigment fusion peptides


The present invention relates to a polypeptide or polypeptide complex, comprising at least one non-ribosomal peptide synthesis (nrps) amino acid module functionally connected to at least one pigment module. The present invention further relates to a labeled oligopeptide comprising a non-naturally attached nrps pigment or/and polyketide pigment, to a polynucleotide encoding a fusion polypeptide, a vector, preferably an expression vector, comprising the polynucleotide of the present invention and to a host cell comprising the polypeptide or polypeptide complex and/or the polynucleotide, and/or the vector according to the present invention.
Ruprecht-karls-universität Heidelberg


Human cancer-related gene, its encoded products and applications


The invention discloses a human cancer-related gene, laptm4b, its encoded products and their applications thereof. This human cancer-related gene provided by this invention comprises one of the following nucleotide sequences: (1) seq id no: 1, seq id no: 2, seq id no: 3, seq id no: 6, or seq id no: 8 in the sequence listings; (2) polynucleotides that encode the protein sequences of seq id no: 4, seq id no: 5, or seq id no: 7 in the sequence listings; (3) dna sequences having above 90% homology with the dna sequences specified by seq id no: 1, seq id no: 2, seq id no: 3, seq id no: 6, or seq id no: 8 in the sequence listings, and these dna sequences encode the proteins with the same or similar functions.
Peking University


Genetic loci associated with resistance of soybean to cyst nematode and methods of use


Various compositions and methods are provided for identifying and selecting plants with enhanced resistance to soybean cyst nematode (scn). Further provided are transgenic plants, plant parts, and seed and methods of their use comprising a heterologous polynucleotide operably linked to a promoter active in the plant are provided, as are methods of making such plants and methods of use, wherein said heterologous polynucleotide comprises at least one, or any combination thereof, of glyma18g2580, glyma18g2590, glyma18g2600, glyma18g2610; and glyma18g2570 or an active variant or fragment thereof.
Pioneer Hi Bred International Inc


Native-extension parallel sequencing


The present invention provides methods for native extension parallel sequencing of polynucleotide.. .
Centrillion Technology Holdings Corporation


Soybean pip1 promoter and its use in constitutive expression of transgenic genes in plants


The disclosure relates to gene expression regulatory sequences from soybean, specifically to recombinant dna constructs comprising the promoter of a soybean plasma membrane intrinsic protein gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E. I. Du Pont De Nemours And Company


Modular rna regulators and methods


This disclosure describes modular mirna regulator molecules and methods of using modular mirna regulator molecules. Generally, the modular mirna regulator molecules include a recognition module and an inhibition module.
Stc.unm


Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


Polypeptides having cellobiohydrolase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


Antibody therapeutics that bind ctla4


There is disclosed compositions and methods relating to or derived from anti-ctla4 antibodies. More specifically, there is disclosed fully human antibodies that bind ctla4, ctla4-antibody binding fragments and derivatives of such antibodies, and ctla4-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


Polynucleotide molecules and uses thereof


The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.. .
Moderna Therapeutics, Inc.


Centrifuge and loading a device


An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array.
Life Technologies Corporation


Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations


An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating , where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.
Rensselaer Polytechnic Institute


Compositions and methods for controlling diabrotica


The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertevrate pest, for instance through rna interference..
Monsanto Technology Llc


Compositions and methods for controlling diabrotica


The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertebrate pest, for instance through rna interference..
Monsanto Technology Llc


Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use


Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Nidera S.a.


Polynucleotide encoding acyl-coa synthetase homolog and use thereof


The present invention relates to an acyl-coa synthetase homolog protein from microorganisms of the genus mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-coa synthetase homolog protein gene from, e.g., mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc..
Suntory Holdings Limited


Polynucleotide encoding acyl-coa synthetase homolog and use thereof


The present invention relates to an acyl-coa synthetase homolog protein from microorganisms of the genus mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-coa synthetase homolog protein gene from, e.g., mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc..
Suntory Holdings Limited


Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities


Isolated aspartyl-trna synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.. .
Atyr Pharma, Inc.


Modified beta-lactamases and methods and uses related thereto


Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.. .

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.


Glucoamylase variants and polynucleotides encoding same


The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


Microorganism with enhanced l-lysine productivity and producing l-lysine by using same


Provided are a beta prime subunit mutant of rna polymerase, a microorganism of the corynebacterium genus including a polynucleotide coding the same, and a method for producing l-lysine by culturing the same.. .
Cj Cheiljedang Corp.


Lucigen yellow (lucy), a yellow fluorescent protein


Described herein are isolated polynucleotides that encode a fluorescent protein which is at least 80% sequence identical to a protein selected from the group consisting of seq. Id.
Lucigen Corporation


Non-enzymatic, salt-mediated synthesis of polynucleic acids


Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid polymerase and lipids, but containing mononucleotides and a monovalent salt; (b) drying and resolubilizing the mixture of step (a) a plurality of times; and (c) recovering polynucleic acids from a resolubilized mixture of step (b). In certain aspects, the method further uses a low ph, e.g.
University Pierre And Marie Curie


Hypoxia-targeted delivery system for pharmaceutical agents


Molecular compositions, nanoparticle compositions, and pharmaceutical compositions of the invention provide for the delivery of a polynucleotide to a hypoxic cell or tissue. The compositions can also be used for the delivery a hydrophobic pharmaceutical agent, either alone or in combination with a polynucleotide, to a hypoxic cell or tissue.
Northeastern University


Single walled carbon nanotube polynucleotide complexes and methods related thereto


The present invention provides single-walled carbon nanotube formulations for the delivery of bioactive agents including large polynucleotides encoding therapeutic proteins into hard-to-transfect cells and methods of making such single-walled carbon nanotube formulations.. .
Ensysce Biosciences, Inc.


Test evaluating the risk of anti-thyroid drug-induced agranulocytosis, and evaluation kit


The present invention provides a test method and an evaluation kit for determining the risk of antithyroid drug-induced agranulocytosis. More particularly, it provides a test method for determining the risk of antithyroid drug-induced agranulocytosis, including testing susceptibility polymorphism to antithyroid drug-induced agranulocytosis, and determining the risk of antithyroid drug-induced agranulocytosis, and an evaluation kit for the risk of antithyroid drug-induced agranulocytosis, containing a polynucleotide capable of detecting susceptibility polymorphism to antithyroid drug-induced agranulocytosis..
Toyo Kohan Co., Ltd.


Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications


Techniques, methods, devices, and compositions are disclosed that are useful in identifying and sequencing natural and synthetic, and modified and unmodified dna, rna, pna, dna/rna nucleotides. The disclosed techniques, methods, devices, and compositions are useful in identifying various modifications, dna/rna damage, and nucleotide structure, using nanoelectronic quantum tunneling spectroscopy, which may be referred to as qm-seq.
The Regents Of The University Of Colorado, A Body Corporate


Nuclear targeting sequences


Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed..
Yeda Research And Development Co. Ltd.


Method of targeting gene delivery using viral vectors


Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus.
California Institute Of Technology


Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use


Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Nidera S.a.


Compositions for targeted delivery of sirna


The present invention is directed compositions for targeted delivery of rna interference (rnai) polynucleotides to hepatocytes in vivo. Targeted rnai polynucleotides are administered together with co-targeted delivery polymers.
Arrowhead Madison Inc.


Novel hydroxyphenylpyruvate dioxygenase polypeptides and methods of use


Novel hydroxyphenyl pyruvate dioxygenase (hppd) polypeptides, variants and fragments thereof, as as well as polynucleotides encoding the same, capable of conferring commercial levels of conferring hppd herbicide resistance or tolerance to plants. Compositions include amino acid sequences, and variants and fragments thereof, for hppd polypeptides, as well as polynucleotides encoding the same.
Syngenta Participations Ag


Albumin variants


The present invention relates to variants of a parent albumin; the variants comprise one or more mutations in domain ii of albumin which lead to a change in binding affinity to fcrn and/or a change in half-life compared to the “parent” albumin. The invention allows tailoring of binding affinity and/or half-life of an albumin to the requirements and desires of a user or application.
Novozymes Biopharma Dk A/s


Nano-constructs for polynucleotide delivery


The present invention provides novel nano-constructs useful for delivering polynucleotides into cells, methods of using the nano-constructs, and methods of making the nano-constructs.. .
The Chinese University Of Hong Kong


Sonogenic stimulation of cells


The invention provides compositions featuring trp-4 polypeptides and polynucleotides, methods for expressing such polypeptides and polynucleotides in a cell type of interest, and methods for inducing the activation of the trp-4 polypeptide in neurons and other cell types using ultrasound.. .
Salk Institute For Biological Studies


Modified vasoactive intestinal peptides


The present invention provides modified vasoactive intestinal peptides (vips), encoding polynucleotides and vectors, as well as pharmaceutical compositions comprising the same. The invention further provides methods of making and using the modified vip agents.
Phasebio Pharmaceuticals, Inc.


Il-1beta-il-1ra chimera and methods of using the same


The present invention provides a chimera protein made of amino acid residues derived from il-1beta propeptide and the il-1ra mature peptide and polynucleotides encoding the protein. The present invention also provides usages of the protein and the polynucleotides in pharmaceutical compositions that treat inflammation..
The Regents Of The University Of Colorado, A Body Corporate


G protein coupled receptors and uses thereof


The present invention provides gpcr polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders.
Omeros Corporation


T cell receptors that are specific to a fluorescent protein, transgenic animals and methods of their making, isolated t cells, and methods of use


This invention relates to a transgenic non-human mammal whose genome comprises a polynucleotide sequence encoding a t cell receptor that is specific to a fluorescent protein, where the t cell of the non-human mammal comprises the t cell receptor. The present invention also relates to an isolated t cell from the transgenic non-human mammal of the present invention, an isolated t cell comprising an expression construct comprising a polynucleotide sequence that encodes a t cell receptor that is specific to a fluorescent protein, methods of making transgenic non-human mammals comprising t cell receptors that are specific to a fluorescent protein, a method of depleting cells in a non-human mammal using isolated t cells that encode a t cell receptor that is specific to a target protein, and a method of characterizing a t cell response to an agent..
Icahn School Of Medicine At Mount Sinai


Translocation and mutant ros kinase in human non-small cell lung carcinoma


In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of cd74 with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The cd74-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
Cell Signaling Technology, Inc.


Compositions and methods for determining likelihood of an increased susceptibility to contracting johne's disease


Collections of polynucleotides useful estimating breeding value or detecting likelihood of an increased susceptibility to contracting paratuberculosis are disclosed. The polynucleotides are used to detect genomic sequences quantitatively associated with an increased susceptibility to contracting paratuberculosis trait.
Wisconsin Alumni Research Foundation (warf)


Methods, compositions, and kits comprising linker probes for quantifying polynucleotides


The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides.
Applied Biosystems, Llc


Methods and devices for nucleic acid synthesis


Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support having a plurality of features.
Gen9, Inc.


Gene synthesis by self-assembly of small oligonucleotide building blocks


The invention provides a process for synthesizing genes and other long double stranded polynucleotides by assembling very short oligonucleotides into partly double stranded polynucleotides, and then connecting these partly double stranded polynucleotide subassemblies with linkers comprised of very short oligonucleotides. In one embodiment, the correct order of the polynucleotide subassemblies is coded in overhangs present at each end of the partly double stranded polynucleotide subassemblies.
Genomic Expression Aps


Crispr hybrid dna/rna polynucleotides and methods of use


The present disclosure provides dna-guided crispr systems; polynucleotides comprising dna, rna and mixtures thereof for use with crispr systems; and methods of use involving such polynucleotides and dna-guided crispr systems.. .
Pioneer Hi-bred International. Inc.


Methods and compositions for modulating gene expression in plants


The present invention provides methods and compositions for regulation of gene expression in plants. In particular, the invention provides nucleic acids that can confer tissue specific and constitutive expression to operably linked polynucleotides of interest..
Clemson University


Polypeptides having endoglucanase activity and polynucleotides encoding same


Polypeptides having endoglucanase activity, catalytic domains, and polynucleotides encoding the polypeptides or catalytic domains. Nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains..
Novozymes A/s


Humanized anti-acth antibodies and use thereof


The present invention is directed to antibodies and fragments thereof having binding specificity for acth. Embodiments of this invention relate to the binding fragments of antibodies described herein, comprising the sequences of the vh, vl and/or cdr polypeptides described herein, and the polynucleotides encoding them.
Alder Biopharmaceuticals, Inc.


Branched and linear chimeric compounds, polynucleotides, uses and methods for preparation thereof


The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds..
Dynavax Technologies Corporation


Inhibitors of polynucleotide repeat-associated rna foci and uses thereof


Compounds which inhibit the formation and/or accumulation of rna foci, such as those due to polynucleotide repeats (e.g., trinucleotide repeats) are described herein. Also described herein are uses of such compounds, such as for the inhibition of the formation and accumulation such rna foci, as well as for the treatment of polynucleotide repeat disorders (e.g., trinucleotide repeat disorders), such as myotonic dystrophy (e.g., dm1).
Valorisation-recherche, Limited Partnership


Compositions, devices, systems, and methods for using a nanopore


Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore.
The Regents Of The University Of California


Method and composition for detection of oncogenic hpv


Probes for the detection of oral oncogenic human papillomavirus (hpv) are described. The probe includes a polynucleotide having at least 90% sequence identity to a polynucleotide complementary to a microrna that has altered expression in response to oncogenic hpv infection.
Notre Dame Du Lac


Use of rhoa in cancer diagnosis and inhibitor screening


Disclosed are a novel method of detecting cancer, a method of screening inhibitors and anticancer agents that target cancer-related molecules, rhoa polypeptide having mutation and a polynucleotide encoding the polypeptide as a therapeutic agent for cancer, and a method of detecting cancer using the polypeptide or polynucleotide. Also disclosed are a vector and a host cell comprising the polynucleotide, a method of screening therapeutic agents for cancer comprising the polypeptide and/or the polynucleotide, and a therapeutic agent for cancer comprising sirna having a silencing effect on rhoa mutant..
Chugai Seiyaku Kabushiki Kaisha


Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to polypeptides having xylanase activity and catalytic domains and polynucleotides encoding the polypeptides and catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and catalytic domains..
Novozymes A/s


Alphaviral vectors and cell lines for producing recombinant proteins


The present invention relates to polynucleotides and alphaviral vectors for the expression of genes of interest in mammalian cells. Additionally, the invention relates to cells which comprise said polynucleotides and alphaviral vectors and are capable of stably expressing one or more genes of interest.
3p Biopharmaceuticals, S.l.


Plant genome modification using guide rna/cas endonuclease systems and methods of use


Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide rna/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed.
Pioneer Hi-bred International, Inc.


Methods for producing genetic modifications in a plant genome without incorporating a selectable transgene marker, and compositions thereof


Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell, without incorporating a selectable transgene marker. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed, without incorporating a selectable transgene marker.
Pioneer Hi-bred International, Inc.


Methods and compositions for inhibiting the function of polynucleotide sequences


A therapeutic composition for inhibiting the function of a target polynucleotide sequence in a mammalian cell includes an agent that provides to a mammalian cell an at least partially double-stranded rna molecule comprising a polynucleotide sequence of at least about 200 nucleotides in length, said polynucleotide sequence being substantially homologous to a target polynucleotide sequence. This rna molecule desirably does not produce a functional protein.
Alnylam Pharmaceuticals, Inc.


Rna agents for p21 gene modulation


This invention provides compounds, compositions and methods for modulating the expression of human p21 using rna interference. The rna interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.
Nitto Denko Corporation


Rna agents for gst-pi gene modulation


This invention provides compounds, compositions and methods for modulating the expression of human gst-π using rna interference. The rna interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.
Nitto Denko Corporation


Protease variants and polynucleotides encoding same


The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


T cell activating bispecific antigen binding molecules


The present invention generally relates to novel bispecific antigen binding molecules for t cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides.
Hoffmann-la Roche Inc.


Mutant interleukin-2 polypeptides


The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the il-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant il-2 polypeptides, polynucleotide molecules encoding the mutant il-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules.
Roche Glycart Ag


Method for measuring modified nucleobase using absorbent polynucleotide and kit for same


An object of the present invention is to provide a technique that suppresses a background value of a detection signal to construct an immunoassay system for detecting a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample and a capture probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the presence of an absorbent polynucleotide in the obtained solution.
Fujirebio Inc.


Analysis of polynucleotides


According to some embodiments herein, methods and kits for labeling and analyzing nucleic acids are provided. In some embodiments, sequence-specific labeling is performed on polynucleotide sequences associated with a host genome, and the presence or absence of patterns characteristic of extragenomic sequences are determined..
Bionano Genomics, Inc.


Novel reporter constructs for compound screening


The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a dna sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the dna sequence-specific transactivator.
Koch Biological Solutions, Llc


Targeted sequencing and uid filtering


Provided herein are methods, compositions, and kits for targeted sequencing of polynucleotides with high accuracy and low amplification and sequencing errors.. .
Roche Molecular Systems, Inc.


Stable nanoreporters


The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to improved, stable nanoreporter probes that are capable of binding to and identifying target molecules based on the probes' uniquely detectable signal.
Nanostring Technologies, Inc.


Digital analysis of molecular analytes using electrical methods


Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte.
Apton Biosystems, Inc.


Chimeric non-ribosomal peptide synthetase


The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a chimeric non-ribosomal peptide synthetase (nrps) fusion protein for the biosynthesis of n-acylglycine biosurfactants within a heterologous expression system.. .
Dow Agrosciences Llc


Enhancing efficiency of retroviral transduction of host cells


The present invention provides methods for enhancing transduction efficiency of a viral vector into a host cell such as an unstimulated stem cell. The methods involve transducing the host cell with the vector in the presence of an samhd1 inhibitor (e.g., a vpx protein), and an inhibitor of mtor complexes (e.g., rapamycin or analog compound thereof).
The Scripps Research Institute


Wheat ms1 polynucleotides, polypeptides, and methods of use


Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility.
Pioneer Hi Bred International Inc


Axmi422 toxin gene and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
Athenix Corp.


Plant resistant to helminthosporium turcicum


The present invention provides an improved helminthosporium turcicum-resistant plant, in particular a maize plant which comprises a polynucleotide with one or more resistance-conferring genes, for example on a truncated chromosome fragment from the accession pepitilla, as well as a cell, a tissue, a part, grain and seeds thereof, an isolated polynucleotide which comprises one or more resistance-conferring genes against helminthosporium turcicum, a vector, a transgenic plant cell and a transgenic plant containing this polynucleotide. Furthermore, the invention encompasses suitable markers and their use in introducing resistance or the transgene into a plant, as well as the identification of improved maize plants which comprise a truncated chromosome fragment..
UniversitÄt ZÜrich


Polynucleotides and methods for making plants resistant to fungal pathogens


This invention relates to polynucleotide sequences encoding a gene that can confer resistance to the plant pathogen colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to the plant pathogen colletotrichum, and processes of making said plants and seeds.
University Of Delaware


Genome modification using guide polynucleotide/cas endonuclease systems and methods of use


Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a cell or organism.
Pioneer Hi-bred International, Inc.


Stabilized recombinant expression plasmid vector in hafnia alvei and applications thereof


One aspect of the present disclosure relates to a stabilized recombinant expression plasmid vector comprising a polynucleotide encoding an antitoxin gene which expresses a polypeptide that neutralizes a polypeptide toxic to a host cell, the toxic polypeptide being expressed by a toxin gene in the host cell, and a polynucleotide encoding a polypeptide expression product, and the stabilized recombinant expression plasmid vector is derived from a hafnia alvei autonomously replicable backbone plasmid. Other aspects of the present disclosure relate to a transformant transformed with the stabilized recombinant expression plasmid vector disclosed herein, a method of producing biobased cadaverine using the transformant disclosed herein, and biobased cadaverine prepared by the method disclosed herein.
Cathay R&d Center Co., Ltd.


Degradable clostridial toxins


The specification discloses clostridial toxins or clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.. .
Allergan, Inc.


Alpha-amylase variants and polynucleotides encoding same


The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


Bacterial host strain


A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated tsp gene, wherein the mutated tsp gene encodes a tsp protein having reduced protease activity or is a knockout mutated tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a protease iii protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated degp gene encoding a degp protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated tsp gene and/or mutated ptr gene and/or mutated degp gene and optionally a polynucleotide sequence encoding a protein of interest.. .
Ucb Pharma, S.a.


Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy


The present invention provide purified flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.. .
Vegenics Pty Limited


Pesticidal nucleic acids and proteins and uses thereof


The invention provides compositions comprising polynucleotide molecules encoding certain pesticidal polypeptides which exhibit plant parasitic nematode and/or insect control properties, and are particularly directed to controlling plant parasitic pest species of nematodes and insects known to infest crop plant species. Methods for controlling pests are disclosed in which the toxic proteins are provided in the diet of the targeted plant pests.
Monsanto Technology Llc




Polynucleotide topics:
  • Nucleotide
  • Polynucleotide
  • Polypeptide
  • Antagonist
  • Nucleic Acid
  • Cancer Cell
  • Drug Resistance
  • Chromosome
  • Glycoprotein
  • Gastrointestinal
  • Gastrointestinal Stromal Tumors
  • Gastrointestinal Stromal Tumor
  • Cellobiohydrolase
  • Human Disease
  • Inflammation


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