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Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
03/26/15
20150089688
 Compositions and methods of gene silencing in plants patent thumbnailnew patent Compositions and methods of gene silencing in plants
Compositions and methods for inducing gene silencing events in plants are disclosed. The compositions typical include a polynucleotide encoding an mirna target sequence operably linked to a sequence of from a target gene, cdna or mrna, or fragment thereof.
The Board Of Trustees Of The University Of Illinois
03/26/15
20150089687
 Novel antifungal proteins and methods of use patent thumbnailnew patent Novel antifungal proteins and methods of use
Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for novel variants of antipathogenic polypeptides generated through dna shuffling that exhibit improved antipathogenic activity.
Pioneer Hi Bred International Inc
03/26/15
20150087695
 Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo patent thumbnailnew patent Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo
Oligonucleotide compounds modulate expression and/or function of erythropoietin (epo) polynucleotides and encoded products thereof. Methods for treating diseases associated with erythropoietin (epo) comprise administering one or more oligonucleotide compounds designed to inhibit the epo natural antisense transcript to patients..
Curna, Inc.
03/26/15
20150087604
 Anti-fatty acid synthase polypeptide and use thereof patent thumbnailnew patent Anti-fatty acid synthase polypeptide and use thereof
The present invention relates to a polypeptide that is capable of inhibiting transcription and expression of fatty acid synthase (fas) and the polynucleotides encoding therefor, as well as the use thereof. Specifically, the present invention relates to a polypeptide that can inhibit the transcription and expression of fas at the molecular level, the cellular level and in vivo, and can therefore prevent the overexpression of fas.
Tianjin Toptech Bio-science & Technology Co., Ltd.
03/26/15
20150087596
 Huwentoxin-iv variants and methods of use patent thumbnailnew patent Huwentoxin-iv variants and methods of use
The present invention relates to huwentoxin-iv variants, polynucleotides encoding them, methods of making and using the foregoing, and methods of alleviating pain with peptide inhibitors of nav1.7.. .
Janssen Biotech, Inc.
03/26/15
20150087557
 Enzyme composition for dna end repair, adenylation, phosphorylation patent thumbnailnew patent Enzyme composition for dna end repair, adenylation, phosphorylation
Enzyme compositions and their method of use that provide ready-to-use master mixtures. The compositions comprise a modified thermophilic dna polymerase lacking 5′-3′ and 3′-5′ exonuclease activity premixed with t4 dna polymerase, klenow fragment and t4 polynucleotide kinase and all other necessary components, including reaction buffer and nucleoside triphosphates, required to perform dna blunting, phosphorylation, and single nucleotide extension reactions in one tube and in two steps.
Thermo Fisher Scientific Baltics Uab
03/26/15
20150087537
 Methods, systems, computer readable media, and kits for sample identification patent thumbnailnew patent Methods, systems, computer readable media, and kits for sample identification
A method for sequencing a polynucleotide sample having a barcode sequence includes: introducing a series of nucleotides to the polynucleotide sample according to a predetermined order of nucleotide flows; obtaining a series of signals resulting from the introducing of nucleotides to the polynucleotide sample; and resolving the series of signals over the barcode sequence to render a flowspace string, wherein the flowspace string is a codeword of an error-correcting code that is (i) designed based on and adapted for use with the predetermined order of nucleotide flows, and (ii) capable of distinguishing any codeword in the error-correcting code from the other codewords in the error-correcting code in the presence of zero, one, and two errors.. .
Life Technologies Corporation
03/26/15
20150087067
 Methods and compositions for inactivating glutamine synthetase gene expression patent thumbnailnew patent Methods and compositions for inactivating glutamine synthetase gene expression
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (gs) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins..
Sangamo Biosciences, Inc.
03/26/15
20150087047
 Process for production of recombinant proteins as a soluble form patent thumbnailnew patent Process for production of recombinant proteins as a soluble form
A target protein is prepared as soluble protein using a recombinant protein expression system. An expression vector is used that includes (1) an expression-inducible promoter sequence; (2) a first coding sequence including a polynucleotide coding for a polypeptide that is represented by the formula (z)n; and (3) a second coding sequence that includes a polynucleotide that codes for a target protein.
Jnc Corporation
03/26/15
20150087029
 Genes encoding cellulase for hydrolyzing guar fracturing fluids under extreme well conditions patent thumbnailnew patent Genes encoding cellulase for hydrolyzing guar fracturing fluids under extreme well conditions
polynucleotide sequences encoding a thermostable cellulase and directing its increased expression are provided, and hydraulic fracturing compositions comprising such thermostable cellulase.. .
Verenium Corporation
03/26/15
20150087027
new patent

Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase


The present invention is directed to methods and compositions for adding tails of specific lengths to a substrate polynucleotide. The invention also contemplates methods and compositions for immobilization of tailed substrates to a solid support.
Swift Biosciences, Inc.
03/26/15
20150086614
new patent

Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.
03/26/15
20150086613
new patent

Lipid-derived neutral nanoparticles


Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells.
Shire Human Genetic Therapies, Inc.
03/26/15
20150086568
new patent

Anti-vegf antibodies


The invention herein provides isolated antibodies that bind to vegf. The invention further provides methods of making anti-vegf antibodies, and polynucleotides encoding anti-vegf antibodies..
Genentech, Inc.
03/26/15
20150086556
new patent

Anti-activin a antibodies and uses thereof


The disclosure provides compositions and methods relating to or derived from anti-activin a binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin a antibodies that bind human activin a, activin a-binding fragments and derivatives of such antibodies, and activin a-binding polypeptides comprising such fragments.
Amgen Inc.
03/26/15
20150086525
new patent

Prebiotic composition or pharmaceutical composition synthesized from catalytic domains producing highly alpha-1,2 branched dextran


The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with .alpha.(1.fwdarw.2) sidechains, comprising at least one region for bonding to glucan and a catalytically active region situated beyond the region bonding to glucan. The invention further relates to polynucleotides coding for said enzymes and vectors containing the same..
Institut National Des Sciences Appliquees (insa)
03/19/15
20150082493

Gh61 polypeptide variants and polynucleotides encoding same


The present invention relates to gh61 polypeptide variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes, Inc.
03/19/15
20150082489

Polynucleotides and polypeptides for increasing desirable plant qualities


Polynucleotides and isolated polypeptides, nucleic acid constructs comprising the isolated polynucleotides, transgenic plants expressing same and methods of using same for increasing abiotic stress tolerance, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, and/or nitrogen use efficiency of a plant are disclosed.. .
Evogene Ltd.
03/19/15
20150082488

Isolated polynucleotides encoding a map65 polypeptide and methods of using same for increasing plant yield


Provided are methods of increasing yield, biomass, growth rate, vigor, and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence at least 80% identical to seq id no: 27 or 868; or an exogenous polynucleotide encoding a polypeptide at least 80% identical to seq id no: 132 (map65 from arabidopsis).. .
Evogene Ltd.
03/19/15
20150082487

Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance, biomass and/or yield in plants expressing same


Provided are isolated polynucleotides comprising a nucleic acid sequence at least 80% identical to seq id no:619, 617, 606, 615, 629, 1-36, 40, 41, 43-45, 49, 52-56, 58, 113-343, 351, 354-358, 605, 607-614, 616, 618, 620-628, 630-638, 642, 645, 650, 651, 670, or 671. Also provided are nucleic acid constructs comprising same, isolated polypeptides encoded thereby, transgenic cells and transgenic plants comprising same and methods of using same for increasing abiotic stress tolerance, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, and/or nitrogen use efficiency of a plant..
Evogene Ltd.
03/19/15
20150082486

Isolated polynucleotides and polypeptides, and methods of using same for increasing yield of plants


Provided are isolated polynucleotides and nucleic acid constructs which comprise a nucleic acid sequence at least 80% identical to a nucleic acid sequence selected form the group consisting of seq id nos: 1-219, 367-5628, 9688-9700, and 9709-9752; and isolated polypeptides which comprise an amino acid sequence at least 80% homologous to an amino acid sequence selected from the group consisting of seq id nos: 220-366, 5629-9400, 9701-9708, and 9753-9796. Also provided are transgenic cells and plants expressing same and methods of using same for increasing yield, growth rate, biomass, vigor, oil content, seed yield, fiber yield, fiber quality, nitrogen use efficiency, and/or abiotic stress of a plant..
Evogene Ltd.
03/19/15
20150082481

Nucleic acid molecules and other molecules associated with transcription in plants and uses thereof for plant improvement


Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
Monsanto Technology Llc
03/19/15
20150082478

Plant genome modification using guide rna/cas endonuclease systems and methods of use


Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide rna/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed.
Pioneer Hi-bred International Inc
03/19/15
20150080456

Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of nuclear respiratory factor 1 (nrf1), in particular, by targeting natural antisense polynucleotides of nuclear respiratory factor 1 (nrf1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of nrf1..
Curna, Inc.
03/19/15
20150080455

Treatment of transcription factor e3 (tfe3) and insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to tfe3


The present invention relate to antisense oligonucleotides that modulate the expression of and/or function of transcription factor e3 (tfe3) and/or insulin receptor substrate 2 (irs2) polynucleotides, in particular, by targeting natural antisense polynucleotides of transcription factor e3 (tfe3) and/or insulin receptor substrate 2 (irs2). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of tfe3 and/or irs2..
Curna, Inc.
03/19/15
20150080306

Therapeutic agents comprising elastic peptides


The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation.
Duke University
03/19/15
20150080241

Polynucleotide and use thereof


A polynucleotide comprising a first region the 5′ end of which is complementary to a portion of a target nucleic acid, a cleavable second region, a third region having a stem-loop structure, and a fourth region complementary to the 3′ end of the first region, and use of the polynucleotide, as well as a composition comprising two such polynucleotides each of which hybridize different strands of a double-stranded target nucleic acid, and methods and kits using the same for amplifying targets.. .
Samsung Electronics Co., Ltd.
03/19/15
20150079106

Anti-neoplastic uses of artemin antagonists


The invention relates to methods for the prophylaxis and treatment of breast cancer using one or more antagonists of artemin function, such as anti-artemin polynucleotides or anti-artemin antibodies and antibody fragments, and uses of these antagonists. In particular, the invention relates to the resensitisation of therapy-resistance breast cancer cells to anti-cancer therapies by antagonism of artemin functionality..
Auckland Uniservices Limited
03/19/15
20150079065

Klotho variant polypeptides and uses thereof in therapy


Disclosed are klotho variant proteins in which residue glu414 and/or residue asp238 is substituted with an amino acid different than l-glu or l-asp, respectively, as well as polynucleotides encoding the variant proteins, and the use thereof in therapy, especially for the treatment of cancers, especially breast cancer and pancreatic cancer.. .
Tel Hashomer Medical Research Infrastructure And Services Ltd.
03/19/15
20150079063

Long-acting coagulation factors and methods of producing same


Polypeptides comprising at least one carboxy-terminal peptide (ctp) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed..
Opko Biologics Ltd.
03/12/15
20150074845

Terminator sequence for gene expression in plants


The present invention discloses polynucleotide sequences that can be used to regulate gene expression in plants. Terminator sequences from sorghum bicolor that are functional in plants are disclosed..
Pioneer Hi Bred International Inc.
03/12/15
20150074844

Drought tolerant transgenic plants and making same


Embodiments of the present invention relate generally to drought tolerant transgenic plants and methods of creating the drought tolerant transgenic plants. In one embodiment, plants are transformed such that a pyl polypeptide is overexpressed in the plant.
Purdue Research Foundation
03/12/15
20150073126

Allium fistulosum leaf agglutinin recombinant protein, its encoding polynucleotide, primer and process for preparation thereof


Nucleic acid sequence encoding allium fistulosum leaf agglutinin (afal) is disclosed. The invention provides allium fistulosum leaf agglutinin (afal) recombinant protein, its encoding nucleotides, primers and the process of preparation thereof, said recombinant protein is useful for insect control and haemagglutination activity.
Council Of Scientific And Industrial Research
03/12/15
20150073040

Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a down syndrome gene, in particular, by targeting natural antisense polynucleotides of a down syndrome gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of down syndrome genes..
Curna, Inc.
03/12/15
20150072919

Fibronectin based scaffold domain proteins that bind to myostatin


The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic kidney disease, heart failure, myocardial infarction, and fibrosis.
Bristol-myers Squibb Company
03/12/15
20150072882

Method of detecting nucleic acids


A method of detecting a target nucleic acid, and a polynucleotide and a composition for detecting a target nucleic acid.. .
Samsung Electronics Co., Ltd.
03/12/15
20150072873

Method and producing sequence verified dna


A method of retrieving a subset of polynucleotide molecules from a mixture of polynucleotide molecules includes receiving a mixture of nucleotide sequences comprising one or more polynucleotide molecules, synthesizing one or more identifier (id) regions onto the one or more polynucleotide molecules, and sequencing members of the population of polynucleotide molecules to associate the sequence of one or more of the molecules (the “polynucleotide sequence”) with the sequence of the attached id region (the “id sequence”). The method also includes generating a bead-bound library of one or more beads comprising subsets of identical polynucleotide molecules.
Cambrian Genomics, Inc.
03/12/15
20150072870

Method for reducing adapter-dimer formation


Methods are provided for ligating a 3′ adapter and a 5′ adapter to a target polynucleotide so as to avoid adapter dimer formation. Embodiments of the methods include adding a blocking oligonucleotide after the first ligation in which a 3′ adapter is ligated to the target polynucleotide so that the blocking oligonucleotide is capable of hybridizing to excess 3′ adapter and the ligated 3′ adapter.
New England Biolabs, Inc.
03/12/15
20150072431

Mature dendritic cell compositions and methods for culturing same


This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (dcs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (idcs) with a first signal comprising an interferon gamma receptor (ifn-γr) agonist and/or a tumor necrosis factor alpha receptor (tnf-αr) agonist to produce signaled dendritic cells; and (b) signaling said signaled dendritic cells with a second transient signal comprising an effective amount of a cd40 agonist to produce ccr7+ mature dendritic cells.
Argos Therapeutics, Inc.
03/12/15
20150072397

Gene encoding cellulase


polynucleotide sequences are provided encoding a thermostable cellulase and directing its increased expression are provided, and the use of the thermostable cellulase in hydraulic fracturing methods and the treatment of flowback fluids.. .
Verenium Corporation
03/12/15
20150072383

Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs


The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered polypeptides having transaminase activity, polynucleotides encoding the polypeptides, methods of the making the polypeptides, and methods of using the polypeptides for the biocatalytic conversion of ketone substrates to amine products.
Codexis, Inc.
03/12/15
20150072354

Compounds and methods for diagnosis and treatment of leishmaniasis


Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more leishmania antigens, or a variant thereof.
Infectious Disease Research Institute
03/12/15
20150072016

Microparticles with adsorbed polynucleotide-containing species


Microparticles with adsorbed polynucleotide-containing species, compositions containing the same, methods of making such microparticles, and uses thereof are disclosed. The microparticles comprise (a) a biodegradable polymer, such as a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, or a polycyanoacrylate, (b) a cationic surfactant such as cetyltrimethylammonium bromide, (c) and a polynucleotide-containing species adsorbed on the surface of the microparticles, wherein the polynucleotide-containing species constitutes at least 5 percent of the total weight of said microparticles.
Novartis Vaccines And Diagnostics, Inc.
03/12/15
20150071957

Polypeptide and immune modulation


The present invention relates to roseburia flagellin, and/or a polynucleotide sequence encoding said roseburia flagellin, and/or a vector comprising said polynucleotide sequence, and/or a host cell, including bacteria, comprising said vector, and/or a host cell, including bacteria, comprising said polynucleotide sequence, for use in modulating the inflammation of a tissue or an organ in a subject.. .
Gt Biologics Ltd
03/12/15
20150071933

Use of annexin a3 as a diagnostic and prognostic biomarker and therapeutic target for treating hepatocellular carcinoma


Annexin a3 (anax3) is utilized as a biomarker for the diagnosis and prognosis of hepatocellular carcinoma (hcc) and the utilization of a monoclonal antibody against anxa3 or antisense polynucleotide against anxa3 mrna for the suppression or treatment of hcc, alone or in combination with other hcc treatment. Monoclonal antibody against anxa3 can be administered for the suppression of tumor growth, metastasis, and chemoresistance..
The University Of Hong Kong
03/05/15
20150065687

Albumin variants


The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes Biopharma Dk A/s
03/05/15
20150065393

Methods and devices for nucleic acid synthesis


Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support having a plurality of features.
Gen9, Inc.
03/05/15
20150065354

Method for characterising a polynucelotide by using a xpd helicase


The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and an xpd helicase.
Oxford Nanopore Technologies Limited
03/05/15
20150064782

Production of fatty acid derivatives


The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell..
Reg Life Sciences, Llc
03/05/15
20150064760

Modified microorganism and methods of using same for producing butadiene and 1-propanol and/or 1,2-propanediol


The present disclosure provides a non-naturally occurring microorganism comprising: one or more polynucleotides encoding one or more enzymes in a pathway that produces acetyl-coa; one or more polynucleotides encoding one or more enzymes in a pathway that catalyze a conversion of crotonyl alcohol, 5-hydroxy-3-ketovaleryl-coa, 3-ketopent-4-enoyl-coa, or 3,5-ketovaleryl-coa to butadiene; one or more polynucleotides encoding one or more enzymes in a pathway that catalyze a conversion of dihydroxyacetone-phosphate to 1-propanol and/or 1,2-propanediol, wherein the microorganism has reduced levels of pyruvate decarboxylase enzymatic activity (e.g., the microorganism comprises a disruption of one or more enzymes that decarboxylate pyruvate and/or a disruption of one or more transcription factors of one or more enzymes that decarboxylate pyruvate), and wherein the microorganism is capable of growing on a c6 sugar as a sole carbon source under anaerobic conditions. Also provided are methods of using the disclosed non-naturally occurring microorganisms in methods for the coproduction of butadiene and 1-propanol and/or 1,2-propanediol..
Braskem S.a.
03/05/15
20150064759

Modified microorganism and methods of using same for producing 2-propanol and1-propanol and/or 1,2-propanediol


The present disclosure provides a non-naturally occurring microorganism comprising: one or more polynucleotides encoding one or more enzymes in a pathway that produces acetyl-coa; one or more polynucleotides encoding one or more enzymes in a pathway that catalyze a conversion of cytosolic acetyl-coa to 2-propanol; one or more polynucleotides encoding one or more enzymes in a pathway that catalyze a conversion of dihydroxyacetone-phosphate to 1-propanol and/or 1,2-propanediol, wherein the microorganism has reduced levels of pyruvate decarboxylase enzymatic activity (e.g., the microorganism comprises a disruption of one or more enzymes that decarboxylate pyruvate and/or a disruption of one or more transcription factors of one or more enzymes that decarboxylate pyruvate), and wherein the microorganism is capable of growing on a c6 sugar as a sole carbon source under anaerobic conditions. Also provided are methods of using the disclosed non-naturally occurring microorganisms in methods for the coproduction of 2-propanol and 1-propanol and/or 1,2-propanediol..
Braskem S.a.
03/05/15
20150064752

Polypeptide conferring acid tolerant property to yeast cell, polynucleotide encoding the same, yeast cell having increased amount of the polypeptide, producing a product by using the yeast cell, and producing acid-tolerant yeast cell


A polypeptide conferring an acid-tolerant property on a yeast cell, a polynucleotide encoding the polypeptide, a yeast cell including an increased amount of the polypeptide, a method of producing a product by using the yeast cell, and a method of producing an acid-tolerant yeast cell are provided.. .
Samsung Electronics Co., Ltd.
03/05/15
20150064708

Rapid targeting assay in crops for determining donor insertion


The present disclosure provides methods for detecting and identifying plant events that contain precision targeted genomic loci, and plants and plant cells comprising such targeted genomic loci. The method can be deployed as a high throughput process utilized for screening a donor dna polynucleotide insertion at the targeted genomic loci.
Dow Agrosciences Llc
03/05/15
20150064704

Complex sets of mirnas as non-invasive biomarkers for early diagnosis of acute myocardial infarction


The present invention relates to non-invasive methods for early diagnosis and/or differential diagnosis of acute myocardial infarction in a blood sample of a subject. Further, the present invention relates to polynucleotides or sets of polynucleotides for detecting mirnas or sets of mirnas for early diagnosis and/or differential diagnosis of acute myocardial infarction in a blood sample of a subject..
Comprehensive Biomarker Center Gmbh
03/05/15
20150064702

Microfluidic valve and making same


The present technology provides for a microfluidic substrate configured to carry out pcr on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge.
Handylab, Inc.
03/05/15
20150064697

P53 cooperation with dna methylation and suicidal interferon response to control silencing of repeats and ncrnas


Provided is a disclosure of methods involving determining rna transcripts transcribed from repeats of polynucleotide sequences, the transcription of which are normally repressed by a combination of functional p53 and dna methylation, and methods of detecting interferon, and determining constitutive activation of an interferon type i response. The methods permit identification of cancerous or precancerous cells, can identify non-functional p53, and provide therapeutic and prophylactic approaches for cancer..
Health Research, Inc.
03/05/15
20150064236

Modified polynucleotides for the production of proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.
03/05/15
20150064235

Modified polynucleotides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.
03/05/15
20150064188

Polypeptide structural motifs associated with cell signaling activity


Isolated polypeptides comprising or consisting essentially of specific structural motifs (e.g., three β-sheets and two α-helices) are provided, wherein the polypeptides exhibit at least one cell signaling and/or other non-canonical activity of biological relevance. Also provided are polynucleotides encoding such polypeptides, binding agents that bind such polypeptides, analogs, variants and fragments of such polypeptides, etc., as well as compositions and methods of identifying and using any of the foregoing..
Atyr Pharma, Inc.
03/05/15
20150064137

Use of engineered viruses to specifically kill senescent cells


Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for inducing apoptosis in a senescent cell comprising administering to the cell a polynucleotide, virus, host cell, or pharmaceutical composition described herein.
Kythera Biopharmaceuticals, Inc.
03/05/15
20150064116

Multilayered magnetic micelle compositions and methods for their use


Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (spion) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide.
University Of South Florida (a Florida Non-profit Corporation)
02/26/15
20150059018

Methods and compositions for producing drimenol


The present invention relates to nucleic acids sequences derived from valeriana officinalis and/or persicaria hydropiper and encoding drimenol synthase polypeptides. The present invention also provides the amino acid sequences of the polypeptides.
Keygene N.v.
02/26/15
20150059014

Polynucleotides and polypeptides in plants


The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
Mendel Biotechnology, Inc.
02/26/15
20150059010

Genome modification using guide polynucleotide/cas endonuclease systems and methods of use


Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a cell or organism.
Pioneer Hi-bred International Inc
02/26/15
20150057338

Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a pancreatic developmental gene, in particular, by targeting natural antisense polynucleotides of a pancreatic developmental gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of pancreatic developmental genes..
Curna, Inc.
02/26/15
20150057335

Novel fusion genes identified in lung cancer


[means for solving] a method for detecting a gene fusion serving as a responsible mutation (driver mutation) for cancer, the method comprising the step of detecting any one of an ezr-erbb4 fusion polynucleotide, a kiaa1468-ret fusion polynucleotide, a trim24-a braf fusion polynucleotide, a cd74-nrg1 fusion polynucleotide, and an slc3a2-nrg1 fusion polynucleotide, or a polypeptide encoded thereby, in an isolated sample from a subject with cancer.. .
02/26/15
20150057182

Methods for analysis of dna fragments


A method of genotyping includes applying a sample solution including a plurality of copies of a sample polynucleotide to an array of sensors. The sample polynucleotide includes a region associated with an allele.
Life Technologies Corporation
02/26/15
20150057179

Methods and compositions for hte diagnosis and treatment of thyroid cancer


Methods for detecting thyroid cancer or thyroid cancer status in a subject are described comprising measuring novel markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for thyroid cancer, and kits for carrying out the methods of the invention.
02/26/15
20150057169

Biomarkers for head-and-neck cancers and precancers


The invention provides markers and methods for detecting head-and-neck precancers, (including opls), cancers and related disease conditions in a subject. The invention also provides localization and imaging methods for head-and-neck precancers (including opls) and cancers, along with kits for carrying out methods of the invention.


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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