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This page is updated frequently with new Polynucleotide-related patents. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds.

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Date/App# patent app List of recent Polynucleotide-related patents
04/10/14
20140101793
 Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/10/14
20140101791
 Resistance genes patent thumbnailnew patent Resistance genes
The present invention relates to polynucleotides encoding adult plant pathogen resistance proteins. Also provided are transgenic plants expressing these polynucleotides to enhance the resistance of the plants to pathogens..
04/10/14
20140100160
 Novel use of c-terminal domain of igfbp-5 comprising heparin-binding domain as an angiogenesis inhibitor patent thumbnailnew patent Novel use of c-terminal domain of igfbp-5 comprising heparin-binding domain as an angiogenesis inhibitor
The present invention relates to a pharmaceutical composition for inhibiting angiogenesis comprising an isolated peptide comprising the heparin-binding domain of insulin-like growth factor-binding protein-5 (igfbp-5), a method for inhibiting angiogenesis using the peptide, a pharmaceutical composition for the prevention or treatment of cancer comprising the peptide, a method for treating cancer using the peptide, a novel angiogenesis-inhibiting peptide derived from heparin-binding domain of igfbp-5, a polynucleotide encoding the peptide, an expression vector comprising the polynucleotide and a transformant comprising the vector.. .
04/10/14
20140100110
 Soybean event dp-305423-1 and compositions and methods for the identification and/or detection thereor patent thumbnailnew patent Soybean event dp-305423-1 and compositions and methods for the identification and/or detection thereor
Compositions and methods related to transgenic high oleic acid/als inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides soybean plants having a dp-305423-1 event which imparts a high oleic acid phenotype and tolerance to at least one als-inhibiting herbicide.
04/10/14
20140099686
 Production of fatty alcohols with fatty alcohol forming acyl-coa reductases (far) patent thumbnailnew patent Production of fatty alcohols with fatty alcohol forming acyl-coa reductases (far)
The disclosure relates to methods of producing fatty alcohols from recombinant host cells comprising genes encoding heterologous fatty acyl-coa reductase (far) enzymes. The disclosure further relates to far enzymes and functional fragments thereof derived from marine bacterium and particularly marine gamma proteobacterium such as marinobacter and oceanobacter; polynucleotides encoding the far enzymes and vectors and host cells comprising the same..
04/10/14
20140099668
 Erk ligands and polynucleotides encoding erk ligands patent thumbnailnew patent Erk ligands and polynucleotides encoding erk ligands
The invention relates to kinase inhibitor ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate erk activity.
04/10/14
20140099667
 Bacteriorhodopsin fusion membrane protein expression system patent thumbnailnew patent Bacteriorhodopsin fusion membrane protein expression system
An expression vector is disclosed, which comprises: a) a polynucleotide sequence encoding a bacteriorhodopsin or a mutant bacteriorhodopsin; b) a multiple cloning site; c) a t7 promoter, d) a polyhistidine tag; e) a first protease cleavage site; f) optionally a second protease cleavage site; and g) optionally a linker; wherein the mutant bacteriorhodopsin comprises the residue corresponding to asn94 of seq id no: 1. Also disclosed is a fusion membrane protein expression system, which comprises: a) a polynucleotide sequence encoding a mutant haloarcula marismortui bacteriorhodopsin/d94n (hmbri/d94n) or a haloquadratum walsbyi bacteriorhodopsin (hwbr); b) a target membrane protein; and c) a t7 promoter, operably linked to the mutant hmbri/d94n or hwbr and the target membrane protein.
04/10/14
20140099401
 Asparaginase enzyme variants and uses thereof patent thumbnailnew patent Asparaginase enzyme variants and uses thereof
The present invention relates to newly identified asparaginase polypeptide variants of seq id no: 3 and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes..
04/03/14
20140096287
 Polypeptides having endoglucanase activity and polynucleotides encoding same patent thumbnailPolypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/03/14
20140096286
 Promoter, promoter control elements, and combinations, and uses thereof patent thumbnailPromoter, promoter control elements, and combinations, and uses thereof
The present document is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The document further relates to the use of such promoters or promoter control elements to modulate transcript levels in plants, and plants containing such promoters or promoter control elements..
04/03/14
20140096281
Axmi232, axmi233, and axmi249 toxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
04/03/14
20140094504
Human toll-like receptor inhibitors and methods of use thereof
Provided herein are human toll-like receptor (tlr)-inhibitors and methods for use in individuals having an autoimmune disease or an inflammatory disorder. The tlr inhibitors of the present disclosure are polynucleotides comprising an inhibitory motif for one or more of tlr7, tlr8 and tlr9..
04/03/14
20140094401
Mitrecin a polypeptide with antimicrobial activity
The present invention provides a mitrecin a polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a mitrecin a polypeptide.
04/03/14
20140094399
Biodegradable poly(beta-amino esters) and uses thereof
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided.
04/03/14
20140094376
Multiplex pyrosequencing using non-interfering noise cancelling polynucleotide identification tags
The present disclosure generally pertains to a multiplex method for analyzing samples comprising using polynucleotide amplification to produce amplified products wherein one or more target sequences are tagged with a non-interfering, non-canceling target-specific polynucleotide identification tag, pyrosequencing the amplified products through the non-canceling target-specific polynucleotide identification tag sequence to detect the presence of one or more specific polynucleotide identification tags. The presence of a specific polynucleotide identification tag being correlated with the presence of a specific target sequence..
04/03/14
20140093956
Modified human thymic stromal lymphopoietin
Modified, furin resistant human tslp polypeptides and polynucleotides encoding the modified human tslp polypeptides are provided. Pharmaceutical compositions, b and t cell activation agents, assays and methods of use are also described..
04/03/14
20140093941
Prokaryotic rnai-like system and methods of use
Provided herein are methods for inactivating a target polynucleotide. The methods use a psirna having a 5′ region and a 3′ region.
04/03/14
20140093940
Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
04/03/14
20140093929
Fatty alcohol forming acyl reductases (fars) and methods of use thereof
The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides variant fatty acyl-coa reductase (far) enzymes, polynucleotides encoding the variant far enzymes, and vectors and host cells comprising the same..
04/03/14
20140093919
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/03/14
20140093915
Il-18 receptor antigen binding proteins
Provided herein are il-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding proteins are also provided.
04/03/14
20140093531
Lutzomyia longipalpis polypeptides and methods of use
Substantially purified salivary lu. Longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed.
04/03/14
20140093527
Compositions and methods for glioblastoma treatment
The present disclosure concerns an oncolytic virus for the treatment of cancer, such as in brain cancer, for example glioblastoma. The oncolytic virus may exhibit reduced levels of neurotoxicity.
04/03/14
20140093508
Toll-like 3 receptor antagonists
Toll like receptor 3 (tlr3) antibody antagonists, polynucleotides encoding tlr3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.. .
03/27/14
20140090114
Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
Recombinant polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
03/27/14
20140088293
Photosynthetic organisms and compositions and methods of generating same
An isolated polynucleotide is provided. The isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide of a type ii reaction center of a photosynthetic organism, the nucleic acid sequence being capable of imparting the type ii reaction center with an activity under a temperature range different than that of the type ii reaction center endogenous to the photosynthetic organism.
03/27/14
20140088008
Novel activin receptor and uses thereof
The present invention provides novel activin iib5 receptor polypeptides capable of binding and inhibiting the activities of activin a, myostatin, or gdf-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides.
03/27/14
20140087442
Glucoamylase variants
The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (sbd) of a glucoamylase.
03/27/14
20140087426
Transcription activator-like effector nucleases (talens)
This application provides transcription activator-like effector nucleases (talens), polynucleotide sequences encoding the talens, expression cassettes for producing talens to target cleavage of nucleic acids, and methods of producing and using the talens.. .
03/27/14
20140087379
Electrochemical polynucleotide detection comprising ligation
Disclosed, for example, are methods comprising cleaving an uncleaved probe to form a cleaved oligonucleotide flap, forming a hybridization complex between the cleaved oligo-nucleotide flap, a bridging oligonucleotide, and a capture oligonucleotide that is immobilized on a surface, such that the oligonucleotide flap and the capture oligonucleotide are hybridized to immediately adjacent, complementary regions of the bridging oligonucleotide, ligating the oligonucleotide flap to the capture oligonucleotide to form an immobilized ligation product, and detecting the ligation product.. .
03/27/14
20140087002
Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat lymphedema and to improve reconstructive surgery
Materials and methods are provided to improve survival of lymph nodes and integration of lymph nodes into a lymphatic network, following lymph node transplantation. The treatment or prevention of lymphedema is also addressed.
03/27/14
20140086948
Tuberculosis rv2386c protein, compositions and uses thereof
The present invention is directed to a polypeptide which comprises: (i) an rv2386c protein sequence; (ii) a variant of an rv2386c protein sequence; of (iii) an immunogenic fragment of an rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis..
03/27/14
20140086920
Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8 associated disorders
The disclosure provides novel molecules related to growth and differentiation factor-8 (gdf-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit gdf-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (als).
03/27/14
20140086885
Methods and compositions for targeted cleavage and recombination
Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same.
03/20/14
20140082767
Method for producing stress tolerant transgenic plant by silencing a gene encoding calcium-dependent lipid-binding protein with c2 domain and applications of the same
A transgenic plant includes a first gene having a first polynucleotide and a recombinant construct having a second polynucleotide. The first polynucleotide is homologous to a atclb gene fragment represented by nucleotide acids 963-1205 of seq id no:1.
03/20/14
20140082766
Antimicrobial peptides and uses thereof
The subject invention pertains to methods and materials for enhancing microbial resistance in plants. Specifically exemplified herein are grapevines transformed with polynucleotides that express a peptide which confers antimicrobial activity..
03/20/14
20140080717
Nucleic acid amplification
In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for nucleic acid amplification. In some embodiments, methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions.
03/20/14
20140080182
Cellulose binding domain variants and polynucleotides encoding same
The present invention relates to cellobiohydrolase variants and cellulose binding domain variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
03/20/14
20140080181
Polynucleotides encoding il-31 monoclonal antibodies
The present invention relates to methods of treating pruritic diseases, including but not limited to contact dermatitis, atopic dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous t cell lymphoma, bullous pemphigoid, alopecia wereata, vitiligo, acne rosacea, prurigo nodularis, scleroderma, herpes simplex virus, or combination thereof by administering il-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies..
03/20/14
20140080178
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
03/20/14
20140079923
Polymer coatings
The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(n-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (pazam), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as pazam, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein..
03/20/14
20140079726
Influenza hemagglutinin and neuraminidase variants
Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided.. .
03/20/14
20140079682
Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same
Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated pon enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type pon.
03/13/14
20140075603
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
03/13/14
20140075599
Plants with altered phytochromes
Polynucleotides encoding polypeptides that increase the light sensitivity of plants were identified. Introduction of the polynucleotides into plants produces plants having altered characteristics, such as decreased height, decreased diameter, decreased petiole length, decreased internode length, decreased hypocotyl length, increased hyponasty or enhanced germination..
03/13/14
20140075597
Compositions and methods comprising male fertility sequences
Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and active fragments and variants thereof, which modulate male fertility.
03/13/14
20140073548
Detergent compositions containing bacillus sp. mannanase and methods of use thereof
The present compositions and methods relate to an endo-b-mannanase cloned from a bacillus sp., polynucleotides encoding the endo-b-mannanase, and methods of use thereof. Formulations containing the endo-β-mannanase are highly suitable for use as detergents..
03/13/14
20140073533
Composition and method for predicting response to trastuzumab therapy in breast cancer patients
This invention relates to a composition and a method for prediction of a response to trastuzumab therapy in a breast cancer patient, and more specifically, a composition, a kit, a dna chip, and a method for predicting a response to trastuzumab therapy by using polynucleotides each comprising a nucleotide sequence represented by any of seq id nos: 1 to 9, 11 to 19, and 21 to 23 in the sequence listing or a nucleotide sequence derived therefrom by substitution of u with t, mutants thereof, derivatives thereof, or fragments thereof comprising at least 16 continuous nucleotides, or a polynucleotide comprising a complementary sequence thereof, and using an increase or decrease in her2 protein expression level as an indicator.. .
03/13/14
20140073513
Self-assembled single molecule arrays and uses thereof
The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations.
03/13/14
20140073512
Compositions and methods for intramolecular nucleic acid rearrangement
Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or mid).
03/13/14
20140073030
Detergent compositions containing bacillus agaradhaerens mannanase and methods of use thereof
The present compositions and methods relate to an endo-β-mannanase cloned from bacillus agaradhaerens, polynucleotides encoding the endo-β-mannanase, and methods of use thereof. Formulations containing the endo-β-mannanase are highly suitable for use as detergents..
03/13/14
20140073028
Mek ligands and polynucleotides encoding mek ligands
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mek activity.
03/13/14
20140073015
Transcription activator-like effector assembly
Described herein are techniques for assembling a polynucleotide encoding a transcription activator-like effector nucleases (talen). The techniques ligate and digest necessary modules for a talen assembly in one reactor or system.
03/13/14
20140073014
Transcription activator-like effector assembly
Described herein are techniques for assembling a polynucleotide encoding a transcription activator-like effector nucleases (talen). The techniques ligate and digest necessary modules for a talen assembly in one reactor or system.
03/13/14
20140073012
Enhanced cellulose degradation
The present disclosure provides compositions and methods related to the degradation of cellulose and cellulose-containing materials. Cdh-heme domain polypeptides and gh61 polypeptides and related polynucleotides and compositions are provided herein.
03/13/14
20140073008
Gene cluster for biosynthesis of cycloclavine
The invention in principle pertains to the field of recombinant manufacture of alkaloids and, in particular, cycloclavine. It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides.
03/13/14
20140073007
Screening and enrichment system for protein expression in eukaryotic cells using a tricistronic expression cassette
The present invention provides a polynucleotide and a method for screening and enriching a recombinant protein expressed in a eukaryotic cell, the polynucleotide comprising a tricistronic expression cassette comprising a) a promoter, b) a gene of interest (goi), c) a reporter gene, d) a selection marker gene, e) an internal ribosome entry site (ires) element, and f) a 2a element. Said method comprises a) transfecting or transducing suitable eukaryotic host cells with the polynucleotides of the present invention, b) culturing the eukaryotic host cells under conditions so as to express the protein of interest, the reporter protein and the selection marker protein in a cell culture selection medium suitable for selecting positively-transfected/transduced cells by means of said selection marker, and c) screening, sorting and/or enriching the cells expressing high levels of protein of interest by means of the reporter protein..
03/13/14
20140072986
Amyloid protein oligomer-binding aptamer
An aptamer having a g-quartet structure and being at least one selected from the group consisting of the following polynucleotides, the aptamer having a binding ability to an amyloid protein oligomer: (1) a polynucleotide comprising a base sequence represented by any one of seq id no:1 to seq id no:18; (2) a polynucleotide comprising a base sequence that includes at least four sets of at least two consecutive guanosine nucleotides and in which one or several bases has been deleted, substituted, or added in a base sequence represented by any one of seq id no:18; and (3) a polynucleotide that is a multimer including the polynucleotide of (1) or (2) as a structural unit.. .
03/13/14
20140072965
1, 2-dichloropropane-to-propene reductive dehalogenase genes
The invention is directed to novel reductive dehalogenase genes encoding for reductive dehalogenases, which are capable of dehalogenating halogenated organic compounds and may be useful for environmental assessment and monitoring, and in the bioremediation of pollutants. In particular, the invention provides isolated polynucleotides of novel reductive dehalogenase genes dcpa and dcpb and fragments thereof as well as isolated polypeptides encoding the dcpa and dcpb proteins or fragments thereof.
03/13/14
20140072959
Rapid tests for insurance underwriting
The present invention relates to rapid test devices, kits and systems comprising the rapid test devices for assessing at least two analytes in a sample derived from a life or health insurance applicant, said at least two analytes being selected from the group consisting of a human immunodeficiency virus (hiv) antigen (e.g., a hiv polypeptide), a hiv polynucleotide, an anti-hiv antibody, a hepatitis c virus (hcv) antigen (e.g., a hcv polypeptide), a hcv polynucleotide, an anti-hcv antibody, a liver enzyme alanine transaminase (alt), a liver enzyme aspartate transaminase (ast), nt-probnp (or nt-probnp), probnp (or probnp), cotinine, nicotine, cocaine, a metabolite of cocaine (e.g., benzoylecgonine), prostate-specific antigen (psa), apolipoprotein a-1 (apoa1), apolipoprotein b (apob), hemoglobin a1c and high-sensitivity c-reactive protein (hscrp). The present invention also relates to methods for using the rapid test devices, kits and systems as part of the assessment of the life or health insurance applications..
03/13/14
20140072595
Gene expression and eradication system in helicobacter pylori
The present invention relates to a gene expression and eradication system for helicobacter pylori (h. Pylori).
03/13/14
20140072589
North american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
The invention provides isolated polynucleotide molecules that comprise a dna sequence encoding an infectious rna sequence encoding a genetically-modified north american prrs virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided..
03/13/14
20140072566
Novel epitope for switching to th2 cell and use thereof
The present invention relates to a novel epitope to convert t cell to type 2 helper t (th2) cell. Specifically, the present invention relates to an epitope constituting the 20th to 30th amino acids (seq id no.2) of extracellular domain (ecd) of activation-inducible tumor necrosis factor receptor (aitr), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting t cell to th2 cell and a method of conversion, a pharmaceutical composition comprising the antibody for preventing or treating autoimmune disease, and a method for treating autoimmune disease using the antibody..
03/13/14
20140072565
Novel epitope for switching to th17 cell and use thereof
The present invention relates to a novel epitope to convert t cell to type 17 helper t (th17) cell. Specifically, the present invention relates to an epitope constituting the 41st to 50th amino acids (seq id no.
03/13/14
20140072511
Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy
The present invention provide purified flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.. .
03/06/14
20140068819
Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same
Provided are methods of increasing tolerance of a plant to abiotic stress, and/or increasing biomass, growth rate, vigor and/or yield of a plant. The methods are effected by expressing within the plant an exogenous polynucleotide encoding a polypeptide comprising an amino acid sequence at least 90% homologous to the amino acid sequence selected from the group consisting of seq id nos:201, 207, 212, 202-206, 208-211, 213-391, 1655, 961-1529, and 1660-1663.
03/06/14
20140068817
Expression of isomers of sucrose increases seed weight, seed number and/or seed size
The present invention provides expression vectors comprising polynucleotides encoding chimeric sucrose isomerases, and methods of using the same. In addition, transgenic plants expressing said chimeric sucrose isomerases are provided.
03/06/14
20140068815
Sorghum maturity gene and uses thereof in modulating photoperiod sensitivity
Compositions relating to the sorghum maturity gene 1 (ma1) and expression control sequences and methods of use thereof are provided. The compositions can be used to modulate flowering and photoperiod sensitivity in a plant.
03/06/14
20140068811
Drought tolerant plants and related constructs and methods involving genes encoding zinc-finger (c3hc4-type ring finger) family polypeptides
Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a zinc-finger (c3hc4-type ring finger) family polypeptide..
03/06/14
20140068810
Use of aldh7 for improved stress tolerance
The present invention relates to the field of plant molecular biology, more particularly to the regulation of genes that increase drought tolerance and yield. Provided herein are methods finding use in agriculture for increasing drought tolerance in dicot and monocot plants.
03/06/14
20140068793
Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention provides compositions and methods for the treatment and prevention of diseases and disorders associated with cobalamin deficiency, including compositions and methods that promote cobalamin uptake.


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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