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Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
01/22/15
20150026843
 Polypeptides having protease activity patent thumbnailnew patent Polypeptides having protease activity
The present invention relates to isolated polypeptides having proteaseactivity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptidesin e.g.
Novozymes A/s
01/22/15
20150025124
 Compositions and methods for the suppression of target polynucleotides from lepidoptera patent thumbnailnew patent Compositions and methods for the suppression of target polynucleotides from lepidoptera
Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant.
E I Du Pont De Nemours And Company
01/22/15
20150024971
 Combined automated parallel synthesis of polynucleotide variants patent thumbnailnew patent Combined automated parallel synthesis of polynucleotide variants
The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.. .
Codexis, Inc.
01/22/15
20150024959
 Method for amplifying cdna derived from trace amount of sample patent thumbnailnew patent Method for amplifying cdna derived from trace amount of sample
The problem to be solved by the present invention is to provide a method for preparing a sample for comprehensively and accurately analyzing gene expression in a single cell or a few cells, for example, by a large-scale dna sequencer. The present invention relates to a method for amplifying cdna from mrna in a cell, comprising: (1) capturing mrna derived from the cell by a first dna probe containing a first tag sequence and a poly t sequence and being immobilized to a solid carrier in a single reaction vessel, and synthesizing a first strand cdna from the mrna by a reverse transcription reaction; (2) removing a reaction reagent from the reaction vessel while keeping the first strand cdna synthesized onto the solid carrier in the reaction vessel; (3) adding a polynucleotide sequence consisting of one type of nucleotides to 3′ terminal of the first strand cdna on the solid carrier; (4) hybridizing a second dna probe containing a second tag sequence and a complementary sequence to the polynucleotide sequence with the cdna to which the polynucleotide sequence is added, and synthesizing a second strand cdna; and (5) performing a dna amplification reaction using the second strand cdna synthesized on the solid carrier as a template..
Hitachi, Ltd.
01/22/15
20150024504
 Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores patent thumbnailnew patent Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide.
The Regents Of The University Of California
01/22/15
20150024498
 Cldn5 mini-promoters patent thumbnailnew patent Cldn5 mini-promoters
Isolated polynucleotides comprising a cldn5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia
01/22/15
20150024463
 Modified polymerases for improved incorporation of nucleotide analogues patent thumbnailnew patent Modified polymerases for improved incorporation of nucleotide analogues
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of dna sequencing..
Illumina Cambridge Limited
01/22/15
20150024447
 Butyraldehyde dehydrogenase mutant, polynucleotide encoding the mutant, vector and microorganism having the polynucleotide, and  producing 1,4-butanediol using the same patent thumbnailnew patent Butyraldehyde dehydrogenase mutant, polynucleotide encoding the mutant, vector and microorganism having the polynucleotide, and producing 1,4-butanediol using the same
A mutant butyraldehyde dehydrogenase (bld), a polynucleotide having a nucleotide encoding the mutant, a vector including the polynucleotide, a microorganism including a nucleotide encoding the mutant, and a method of producing 1,4-butanediol using the same.. .
Samsung Electronics Co., Ltd.
01/22/15
20150024446
 Methods for improving malic acid production in filamentous fungi patent thumbnailnew patent Methods for improving malic acid production in filamentous fungi
The present invention relates to methods of producing a c4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a c4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the c4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the c4 dicarboxylic acid. The present invention also relates to methods for increasing c4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants..
Novozymes, Inc.
01/22/15
20150024439
 Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same patent thumbnailnew patent Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
Novozymes, Inc.
01/22/15
20150023996
new patent

Polynucleotides for treating oncogenic viral polypeptide positive tumors


This document relates to polynucleotides encoding antigenic polypeptides to induce an immune response to oncogenic viral polypeptides. Also provided are compositions comprising polynucleotides encoding antigenic polypeptides, and methods of use.
Sanford Research/usd
01/22/15
20150023924
new patent

Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues


The invention relates to adeno-associated virus (aav) serotype aav-rh74 and related aav vectors, and aav-rh74 and related aav vector mediated gene transfer methods and uses. In particular, aav-rh74 and related aav vectors target polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences..
The Children's Hospital Of Philadelphia
01/15/15
20150020241

S-adenosylmethionine synthetase expression elements identified from arabidopsis thaliana


The present invention provides non-coding regulatory element polynucleotide molecules isolated from the s-adenosyl methionine synthetase (sams3) gene of arabidopsis thaliana and useful for expressing transgenes in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the arabidopsis thaliana regulatory polynucleotide sequences, and methods for preparing and using the same..
Monsanto Technology Llc
01/15/15
20150018533

Repebody against immunoglobulin g and uses thereof


The present invention relates to a polypeptide (repebody) selectively bound to an immunoglobulin g, a polynucleotide which encodes the repebody, a vector containing the polynucleotide, a recombinant microorganism in which the polynucleotide is introduced, a method for producing the repebody using the recombinant microorganism, and a method for immobilizing or purifying an immunoglobulin g using the repebody. The repebody according to the present invention is useful as utilized for immobilization of an immunoglobulin g, purification of an immunoglobulin g, and production of an immunosensor, since the repebody selectively bound to an immunoglobulin g..
Korea Advanced Institute Of Science And Technology
01/15/15
20150018521

Endoplasmic reticulum localization signals


The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or multimeric form.
Intrexon Corporation
01/15/15
20150018229

Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (mrp-1) and their use in diagnostic and therapeutic applications


The present invention relates to a polymorphic mrp-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and a polypeptide encoded by the polynucleotide or the gene or obtainable by the method or cells produced herein.
Transgenomic, Inc.
01/15/15
20150018225

Cell adhesion inhibitor, cell proliferation inhibitor, and method and kit for examining cancer


According to one aspect of the present invention, there is provided a cell proliferation inhibitor or a cell adhesion inhibitor for a cancer cell, containing an antibody to a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by seq id no: 2 or a partial peptide thereof. According to another aspect of the present invention, there is provided a cell adhesion inhibitor for a cancer cell, containing an antisense polynucleotide containing a complementary or substantially complementary base sequence to a base sequence of a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by seq id no: 2 or a part thereof.
01/15/15
20150017698

Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate


The present disclosure relates to recombinant host cells comprising one or more recombinant polynucleotides encoding enzymes in select pathways that provide the ability to use the cells to produce 1,3-butadiene. The present disclosure also provides methods of manufacturing the recombinant host cells, and methods for the use of the cells to produce 1,3-butadiene.
Codexis, Inc. A Corporation
01/15/15
20150017696

Recombinant host cells and processes for producing 1,3-butadiene through a crotonol intermediate


The present disclosure relates to recombinant host cells comprising one or more recombinant polynucleotides encoding enzymes in select pathways that provide the ability to use the cells to produce 1,3-butadiene. The present disclosure also provides methods of manufacturing the recombinant host cells, and methods for the use of the cells to produce 1,3-butadiene, either through formation of the intermediate compound crotonol followed by chemo-catalytic dehydration to 1,3-butadiene, or through the use of a recombinant cell comprising a fully enzymatic pathway capable of converting crotonyl-coa or crotonyl-acp to crotonol and then crotonol to 1,3-butadiene..
Codexis, Inc. A Corporation
01/15/15
20150017695

Ketoreductase polypeptides for the reduction of acetophenones


The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds..
Codexis, Inc.
01/15/15
20150017692

Beta-glucosidase


The present invention relates to a polypeptide which has β-glucosidase activity, and which includes an amino acid sequence represented by seq id no: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by seq id no: 1, or a polypeptide including an amino acid sequence having 92% or greater sequence identity with the amino acid sequence represented by seq id no: 1. According to the present invention, a novel β-glucosidase enzyme derived from acremonium cellulolyticus, a polynucleotide encoding the β-glucosidase, an expression vector for expressing the β-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the β-glucosidase can be provided..
Honda Motor Co., Ltd.
01/15/15
20150017691

ß-glucosidase


The present invention relates to a polypeptide which has β-glucosidase activity, and which includes an amino acid sequence represented by seq id no: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by seq id no: 1, or a polypeptide including an amino acid sequence having 92% or greater sequence identity with the amino acid sequence represented by seq id no: 1. According to the present invention, a novel β-glucosidase enzyme derived from acremonium cellulolyticus, a polynucleotide encoding the β-glucosidase, an expression vector for expressing the β-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the β-glucosidase can be provided..
Honda Motor Co., Ltd.
01/15/15
20150017690

Beta-glucosidase


The present invention relates to a polypeptide which has β-glucosidase activity, and which includes an amino acid sequence represented by seq id no: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by seq id no: 1, or a polypeptide including an amino acid sequence having 91% or greater sequence identity with the amino acid sequence represented by seq id no: 1. According to the present invention, a novel β-glucosidase enzyme derived from acremonium cellulolyticus, a polynucleotide encoding the β-glucosidase, an expression vector for expressing the β-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the β-glucosidase can be provided..
Honda Motor Co., Ltd.
01/15/15
20150017689

ß-glucosidase


The present invention relates to a polypeptide which has β-glucosidase activity, and which includes an amino acid sequence represented by seq id no: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by seq id no: 1, or a polypeptide including an amino acid sequence having 90% or greater sequence identity with the amino acid sequence represented by seq id no: 1. According to the present invention, a novel β-glucosidase enzyme derived from acremonium cellulolyticus, a polynucleotide encoding the β-glucosidase, an expression vector for expressing the β-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the β-glucosidase can be provided..
Honda Motor Co. Ltd.
01/15/15
20150017173

Antibodies to human transmembrane proteins


The invention provides human transmembrane proteins (htmpn) and polynucleotides which identify and encode htmpn. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
Incyte Corporation
01/15/15
20150017136

Methods for engineering allogeneic and highly active t cell for immunotherapy


The present invention relates to methods for developing engineered t-cells for immunotherapy that are non-alloreactive. The present invention relates to methods for modifying t-cells by inactivating both genes encoding t-cell receptor and an immune checkpoint gene to unleash the potential of the immune response.
Cellectis
01/08/15
20150013033

Lignification reduction in plants


The present invention provides an expression cassette containing a polynucleotide coding sequence for a hydroxycinnamoyl-coa hydratase-lyase (hchl), which is operably linked to a heterologous promoter. Also provided are methods of engineering plants that have reduced lignification, as well as cells, plant parts, and plant tissues from such engineered plants..
The Regents Of The University Of California
01/08/15
20150013030

Plant transcriptional regulators


The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having improved tolerance to drought, shade, and low nitrogen conditions, as compared to wild-type or reference plants.. .
Mendel Biotechnology, Inc.
01/08/15
20150011464

Antibacterial polypeptides and use thereof


The present invention discloses polypeptides with antibacterial properties and use said polypeptides and/or polynucleotides encoding said polypeptides in the preparation of medicament for the treatment of infectious diseases. The inventors also provide vectors encoding and adapted for expression of the polypeptides and polynucleotides of the invention.
Oslo Universitetssykehus Hf
01/08/15
20150011435

Methods for sequencing nucleic acid molecules


Methods and compositions for determining the nucleic acid sequence of polynucleotides that are at least 1500 nucleotides in length are provided.. .
President And Fellows Of Harvard College
01/08/15
20150010985

Methods and compositions for improving sugar transport, mixed sugar fermentation, and production of biofuels


The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell.
Bp Corporation North America Inc.
01/08/15
20150010961

Polypeptide having endoglucanase activity


The present invention relates to a family 5 glycoside hydrolase variant having endoglucanase activity, polynucleotides encoding the family 5 glycoside hydrolase variant, vectors, host cells comprising the polynucleotides, and methods for using the family 5 glycoside hydrolase variant.. .
Bp Corporation North America Inc.
01/08/15
20150010946

Polynucleotides encoding zcytor17 ligand antibodies


The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine.
Zymogenetics, Inc.
01/08/15
20150010920

Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity


Embodiments of the present disclosure provide for enzyme sensors, protease sensors, methods for producing and using the enzyme and protease sensors, methods of detecting and/or measuring protease activity, methods for characterizing protease cellular activity, fusion proteins, polynucleotides, and vectors corresponding to the enzyme and protease sensors, kits, and the like.. .
Georgia State University Research Foundation, Inc.
01/08/15
20150010915

Crystal structure of the nanr and mannac-6p complex, and uses thereof


The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of nanr which is a key pathogenic regulatory protein of vibrio vulnificus and manna6p which is a nanr regulator. Further, the present invention relates to a modified nanr protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector.
Korea Research Institute Of Bioscience And Biotechnology
01/08/15
20150010597

Compositions and methods for vaccinating against hsv-2


This invention relates to therapeutic polynucleotide compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in mammals. The polynucleotide compositions are particularly effective for protecting mammals from herpes simplex virus (hsv), such as hsv gd2, vp11/12, and vp13/14 polypeptides..
The University Of Washington
01/08/15
20150010577

Translocation and mutant ros kinase in human non-small cell lung carcinoma


In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of cd74 with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The cd74-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
Cell Signaling Technology, Inc.
01/08/15
20150010527

Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy


Plant-expressed human recombinant dnase proteins, nucleic acid constructs for expression of the human recombinant dnase i in plant cells, cells expressing the nucleic acid construct and therapeutic uses thereof are disclosed. Particularly, compositions and methods for treating pulmonary and/or respiratory conditions by inhalation of the plant-expressed human recombinant dnase i are provided..
Protalix Ltd.
01/08/15
20150010518

Nr2e1 mini-promoters


Isolated polynucleotides comprising a nr2e1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia
01/08/15
20150010500

Homogeneous preparations of il-31


Homogeneous preparations of human and murine il-31 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity..
Zymogenetics, Inc.
01/01/15
20150007369

Gh61 polypeptide variants and polynucleotides encoding same


The present invention relates to gh61 polypeptide variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s
01/01/15
20150007365

Promoter, promoter control elements, and combinations, and uses thereof


The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels in plants, and plants containing such promoters or promoter control elements..
Ceres, Inc.
01/01/15
20150007364

Isolated polynucleotides expressing or modulating micrornas or targets of same, transgenic plants comprising same and uses thereof


Disclosed are isolated polynucleotides expressing or modulating micrornas or targets. Further disclosed are transgenic plants comprising an isolated polynucleotide expressing or modulating micrornas or target for improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant.
A.b. Seeds Ltd. A Corporation
01/01/15
20150007363

Heat stable mutants of starch biosynthesis enzymes


The subject invention pertains to novel mutant polynucleotide molecules that encode enzymes that have increased heat stability. These polynucleotides, when expressed in plants, result in increased yield in plants grown under conditions of heat stress.
University Of Florida Research Foundation, Inc.
01/01/15
20150007361

Maize stress-responsive nac transcription factors and methods of use


Methods and compositions for modulating plant development are provided. Polynucleotide sequences encoding zmsnac polypeptides are provided, as are the amino acid sequences of the encoded polypeptides.
Pioneer Hi Bred International Inc
01/01/15
20150005447

Catalyst-free surface functionalization and polymer grafting


Some embodiments described herein relate to a substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives.
Illumina, Inc.
01/01/15
20150005372

Compositions and methods of altering cholesterol levels


The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.
01/01/15
20150004671

Subtilisin variants and polynucleotides encoding same


The present invention relates to subtilisin variants and methods for obtaining subtilisin variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s
01/01/15
20150004656

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.
01/01/15
20150004655

Cellobiohydrolase variants and polynucleotides encoding same


The present invention relates to cellobiohydrolase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of producing and using the variants..
Novozymes, Inc.
01/01/15
20150004165

Secreted proteins


The invention provides human secreted proteins (secp) and polynucleotides which identify and encode secp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
Incyte Corporation
12/25/14
20140380529

Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.
12/25/14
20140380527

Polypeptides having lysozyme activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having lysozyme activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s
12/25/14
20140380525

Plants having enhanced nitrogen efficiency


A transgenic plant comprising a polynucleotide encoding a nitrogen utilization protein operably linked to a pbpr1 promoter is provided. The transgenic plant exhibits increased nitrogen use efficiency, increased biomass and/or increased seed yield.
Bayer Cropscience Ag
12/25/14
20140380523

Isolated polynucleotides and polypeptides and methods of using same for increasing plant utility


Provided are isolated polypeptides comprising the amino acid sequence at least 80% homologous to seq id no:68, 51-66, 69-100, 379-656, 707-715, 720-723, 742-754, 764-771 or 772 with the proviso that the amino acid sequence is not as set forth by seq id no: 765 or 771, isolated polynucleotides comprising the nucleic acid sequence at least 80% identical to seq id nos:18, 1-16, 19-50, 101-378, 657-672, 674-706, 716-719, 724-741 and 755-763 with the proviso that the nucleic acid sequence is not as set forth by seq id no:756 or 762, and isolated polynucleotides selected from the group consisting of seq id nos:779-792 and methods of using same for increasing oil content, yield, growth rate, biomass, vigor, abiotic stress tolerance and/or nitrogen use efficiency of a plant.. .
Evogene Ltd.
12/25/14
20140380521

Axmi277 nematode toxin and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
Athenix Corp.
12/25/14
20140378667

Transgenic plants modified for reduced cadmium transport, derivative products, and related methods


Various embodiments are directed to transgenic plants, including transgenic tobacco plants and derivative seeds, genetically modified to impede the transport of cadmium (cd) from the root system to aerial portions of transgenic plants by reducing the expression levels of hma-related transporters. Various embodiments are directed to transgenic tobacco plants genetically modified to stably express a rnai construct encoding rnai polynucleotides that enable the degradation of endogenous nthma rna variants.
Philip Morris Usa Inc.
12/25/14
20140378315

Enzymatic ligation of nucleic acids


Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length.
Life Technologies Corporation
12/25/14
20140377841

Detergent compositions containing bacillus agaradhaerens mannanase and methods of use thereof


The present compositions and methods relate to an endo-β-mannanase cloned from bacillus agaradhaerens, polynucleotides encoding the endo-β-mannanase, and methods of use thereof. Formulations containing the endo-β-mannanase are highly suitable for use as detergents..
Danisco Us Inc.
12/25/14
20140377827

Hybrid polypeptides having cellobiohydrolase activity and polynucleotides encoding same


The present invention provides hybrid polypeptides having cellobiohydrolase activity. The present invention also provides polynucleotides encoding the hybrid polypeptides; nucleic acid constructs, vectors and host cells comprising the polynucleotides; and processes of using the hybrid polypeptides..
Novozymes, Inc.
12/25/14
20140377803

Enhancement of protein production yield mediated by a fast shuttling cdc42 gtpase


The present invention relates to a cell for producing a secreted protein comprising a polynucleotide comprising a nucleic acid sequence encoding a fast cycling cdc42 mutant and a polynucleotide comprising a nucleic acid sequence encoding a secreted protein. It also relates to a method for producing said cell and to a method for producing a secreted protein using said cell..
Probiogen Ag
12/25/14
20140377801

Artificial signal peptide for expressing an insoluble protein as a soluble active form


The present invention relates to expression vectors and methods for enhancing soluble expression and secretion of an insoluble heterologous protein, particularly a bulky folded active heterologous protein which has one or more transmembrane-like domains or intramolecular disulfide bonds by linking a leader peptide with acidic or basic pl and high hydrophilicity thereto; by substituting one or more amino acids within n-terminal of the heterologous protein with ones having acidic or neutral pl and high hydrophilicity; or reducing elevating Δgrna value of a polynucleotide encoding the leader peptide having basic pl value and high hydrophilicity. The expression vector and the method may be used to produce of heterologous protein and to transduce of therapeutic proteins in a patient by preventing formation of insoluble inclusion body and by enhancing secretional efficiency of the heterologous protein into the periplasm or outside cell..
Republic Of Korea (republic Of National Fisheries Research And Development Institute)
12/25/14
20140377780

Vascular tumor markers


The present invention relates to a method for identifying neovascular structures in mammalian tissue, wherein said neovascular structures are identified by the detection of at least one specific protein in said tissue. It also relates to a method for identifying diseases or conditions associated with neovascularization, methods for targeting and/or imaging neovascular structures and methods for targeting diseases or conditions associated with neovascularization.
Philogen Spa
12/25/14
20140377748

Method to quantify sirnas, mirnas and polymorphic mirnas


The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of rna to the 5′ end of dna using a dna template, such as t4 dna ligase.
Applied Biosystems, Llc
12/25/14
20140377407

Alpha-amylase


The invention relates to a newly identified polynucleotide sequence from alicyclobacillus pohliae comprising a gene that encodes the novel alpha-amylase enzyme. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein of the gene.
12/25/14
20140377297

Recombinant proteins of parapoxvirus ovis and pharmaceutical compositions therefrom


The invention relates to polynucleotides coding for the ppvo viral genome, to fragments of the polynucleotides coding for the ppvo genome and to polynucleotides coding for individual open reading frames (orfs) of the ppvo viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions..
Aicuris Gmbh & Co. Kg
12/25/14
20140377261

Vaccines against antigens involved in therapy resistance and methods of using same


Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject.
Duke University
12/18/14
20140373199

Polypeptides having beta-xylosidase activity and polynucleotides encoding same


Provided are isolated polypeptides having beta-xylosidase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.
12/18/14
20140373195

Axmi345 delta-endotoxin gene and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
Athenix Corp.
12/18/14
20140373193

Use of ospp18 gene in controlling rice drought resistance


The use of ospp18 gene in the genetic improvement of drought resistance of a plant is provided. A plant or plant cell comprising a recombinant dna molecule comprising a polynucleotide encoding ospp18, a method for producing the plant, a dna construct comprising a polynucleotide encoding ospp18 are also provided..
Huazhong Agricultural University
12/18/14
20140373191

Soybean transgenic event mon87751 and methods for detection and use thereof


The invention provides a transgenic glycine max event mon87751, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event mon87751. The invention also provides polynucleotides specific for event mon87751, plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides for event mon87751.
Monsanto Technology, Llc


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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