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Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
10/09/14
20140304859
 Polypeptides having endoglucanase activity and polynucleotides encoding same patent thumbnailPolypeptides having endoglucanase activity and polynucleotides encoding same
Provided are isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
10/09/14
20140303093
 Micro-utrophin polypeptides and methods patent thumbnailMicro-utrophin polypeptides and methods
Described herein are polypeptides, polynucleotides and methods involving a μ-utrophin region or an anti-dystrophinopathic fragment thereof operationally linked to a second region effective to transduce the fusion protein into mammalian muscle cells.. .
10/09/14
20140303036
 Nucleic acid assembly system patent thumbnailNucleic acid assembly system
The present invention relates to a method for the preparation of a library of host cells, a plurality of which comprise an assembled polynucleotide at a target locus, which method comprises: (a) providing a plurality of polynucleotides comprising two or more polynucleotide subgroups, wherein: (i) a plurality of polynucleotides in each polynucleotide subgroup comprises sequence encoding a peptide or polypeptide and/or a regulatory sequence; (ii) a plurality of peptides or polypeptides encoded by, or a plurality of regulatory sequences comprised within, each polynucleotide subgroup share an activity and/or function; (iii) at least one polynucleotide subgroup comprises at least two non-identical polynucleotide species; (iv) a plurality of polynucleotides of each polynucleotide subgroup comprises sequence enabling homologous recombination with a plurality of polynucleotides from one or more other polynucleotide subgroups; and (v) a plurality of polynucleotides in two polynucleotide subgroups comprise a nucleotide sequence enabling homologous recombination with a target locus in host cells; and (b) assembling the plurality of polynucleotides at the target locus by homologous recombination in vivo in host cells, thereby to generate a library of host cells, a plurality of which comprise an assembled polynucleotide at the target locus. The assembled polynucleotides may be recovered, thereby to prepare a library of nucleic acids..
10/09/14
20140303032
 Systems and methods for determining genetic data patent thumbnailSystems and methods for determining genetic data
Systems and methods of polynucleotide sequencing are provided. Systems and methods optimize control, speed, movement, and/or translocation of a sample (e.g., a polynucleotide) within, through, or at least partially through a nanopore or a type of protein or mutant protein in order to accumulate sufficient time and current blocking information to identify contiguous nucleotides or plurality of nucleotides in a single-stranded area of a polynucleotide..
10/09/14
20140303008
 Colorectal cancer associated circulating nucleic acid biomarkers patent thumbnailColorectal cancer associated circulating nucleic acid biomarkers
The invention provides methods and reagents for diagnosing colorectal cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated. In some embodiments, the cna biomarkers are polynucleotide fragments, e.g., dna fragments, that are present at an elevated level in blood, e.g., in a serum or plasma sample, of a colorectal cancer patient in comparison to the level in blood, e.g., a serum or plasma sample, obtained from a normal individual who does not have colorectal cancer..
10/09/14
20140302607
 Polymer based polynucleotide transfection agents patent thumbnailPolymer based polynucleotide transfection agents
The present invention provides a methodology for transfecting cells in vitro. In particular, cationic polymers and polynucleotide containing polyplexes comprising such polymers are provided..
10/09/14
20140302588
 Variant cbh2 cellulases and related polynucleotides patent thumbnailVariant cbh2 cellulases and related polynucleotides
The invention provides variants of a streptomyces sp. Cbh2 that have improved properties compared to the wild type enzyme and methods of using the variants in the hydrolysis of substrates comprising cellulose..
10/09/14
20140302586
 Variants of a family 44 xyloglucanase patent thumbnailVariants of a family 44 xyloglucanase
The present invention relates to variants of a parent xyloglucanase. The present invention also relates to polynucleotides encoding the variant xyloglucanases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide..
10/09/14
20140302517
 Anti-idiotype antibody against anti-c-met antibody patent thumbnailAnti-idiotype antibody against anti-c-met antibody
Disclosed are an anti-idiotype antibody that specifically binds to an idiotope site of an anti-c-met antibody, the use of the anti-idiotype antibody for detecting the anti-c-met antibody, and methods, polypeptides, polynucleotides, compositions, and vaccines related thereto.. .
10/09/14
20140302498
 Rapid detection of the Rapid detection of the "high virulent" st-17 clone of group b streptococcus
The present invention also relates to kits and methods for the specific detection of group b streptococcus highly-virulent st-17 clones, using the polynucleotides, the polypeptides or the antibodies according to the invention.. .
10/09/14
20140302172
Markers for susceptibility to an inhibitor of an src-family kinase
The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the src family, whereby the individual is suspected to suffer from cancer.
10/09/14
20140302033
Albumin binding antibodies and binding fragments thereof
A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in seq id no: 1 or seq id no:2 and/or comprising a light chain variable domain having the sequence given in seq id no:3 or seq id no:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in seq id no: 1 and seq id no:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in seq id no: 2 and seq id no:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides.
10/09/14
20140300339
Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide
The present invention provides technology that uses current measurements to identify nucleotides and determine a nucleotide sequence in polynucleotides. The present invention calculates a modal value of a tunnel current that arises when a nucleotide or polynucleotide for analysis passes through between electrodes, and then employs the calculated modal value.
10/02/14
20140298547
Dna detection methods for site specific nuclease activity
The present disclosure provides methods for detecting and identifying plant events that contain precision targeted genomic loci, and plants and plant cells comprising such targeted genomic loci. The method can be deployed as a high throughput process utilized for screening the intactness or disruption of a targeted genomic loci and optionally for detecting a donor dna polynucleotide insertion at the targeted genomic loci.
10/02/14
20140298542
Nucleic acid agents for overexpressing or downregulating rna interference targets and uses of same in improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant
A method of improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant is provided by expressing within the plant an exogenous polynucleotide encoding a polypeptide having an amino acid sequence at least 80% homologous to seq id nos: 687-981, 992-1248, 1281-1310, 1389-1391, and 2806-3081. Also provided is a method of improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plan by expressing within the plant an exogenous polynucleotide which downregulates an activity or expression of a polypeptide having an amino acid sequence at least 80% homologous to seq id nos: 311-514, 2007-2436, 1311-1320, 982-991, 1249-1280, 1321-1388.
10/02/14
20140298541
Isolated polynucleotides expressing or modulating dsrnas, transgenic plants comprising same and uses thereof in improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant
A method of improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant is provided by expressing within the plant an exogenous polynucleotide at least 90% identical to seq id nos: 1-56, 62, 63, 110, 116, 117, 119-161, 200, 201-255, 1027-1031, 1459-1836. Also provided is a method of improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant by expressing within the plant an exogenous polynucleotide which downregulates an activity or expression of a gene encoding an rnai molecule having a nucleic acid sequence selected from the group consisting of seq id nos: 57-61, 64-115, 118, 162-200, 260-262, 265-267, 271, 1032-1455, 1810-1827, 1842-2265, 2620-2643, 2742-2792.
10/02/14
20140298538
Axmi205 variant proteins and methods of use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided.
10/02/14
20140298510
Manipulation of dominant male sterility
Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and fragments and variants thereof, which modulate male fertility.
10/02/14
20140298508
Alpha-mannosidases from plants and methods for using the same
The present invention is directed to alpha-mannosidase sequences from plants and the use thereof, especially genomic nucleotide sequences containing the regulatory elements controlling their expression, intron and exon sequences and polynucleotide sequences coding for alpha-mannosidase enzymes. Such plants with modified alpha-mannosidase activity can be used for the production of glycoproteins having an altered saccharide composition of great benefit.
10/02/14
20140298500
Mutant protease biosensors with enhanced detection characteristics
A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the c-terminal portion of the thermostable luciferase to the n-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase.
10/02/14
20140296320
Use of sirna to achieve down regulation of an endogenous gene in combination with the use of a sense construct to achieve expression of a polynucleotide
The present invention relates to the combinatorial use of an sirna targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.. .
10/02/14
20140296142
Gene therapy for diabetic neuropathy using an hgf isoform
The present invention relates to a pharmaceutical composition for the prevention or treatment of diabetic neuropathy, wherein the pharmaceutical composition comprises, as active ingredients, different types of isoforms of hgf or a polynucleotide encoding the isoforms. The present invention is the first invention demonstrating that diabetic neuropathy can be prevented and treated using different types of isoforms of hgf.
10/02/14
20140296111
Protein-immobilizing solid phase, polynucleotide-immobilizing solid phase, and nucleic acid recovery method
A protein-immobilizing solid phase is a protein-immobilizing solid phase comprising an mrna-nucleic acid linker-protein complex, obtained by linking the mrna and the protein encoded by that mrna through the nucleic acid linker, immobilized on the solid phase, wherein the nucleic acid linker has a photocleavage site and a solid phase binding site.. .
10/02/14
20140296080
Methods, systems, and computer readable media for evaluating variant likelihood
A method for evaluating variant likelihood includes: providing a plurality of template polynucleotide strands, sequencing primers, and polymerase in a plurality of defined spaces disposed on a sensor array; exposing the plurality of template polynucleotide strands, sequencing primers, and polymerase to a series of flows of nucleotide species according to a predetermined order; obtaining measured values corresponding to an ensemble of sequencing reads for at least some of the template polynucleotide strands in at least one of the defined spaces; and evaluating a likelihood that a variant sequence is present given the measured values corresponding to the ensemble of sequencing reads, the evaluating comprising: determining a measurement confidence value for each read in the ensemble of sequencing reads and modifying at least some model-predicted values using a first bias for forward strands and a second bias for reverse strands.. .
10/02/14
20140295526
Modified proteases
This invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the present invention relates to methods for altering the expression of proteases in microorganisms, such as bacillus species.
10/02/14
20140295523
Glucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-d-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-d-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-d-glucans or xyloglucans and other plant material containing cellulosic parts.
10/02/14
20140295504
Fungal cells and fermentation processes
The present invention provides an isolated fungal cell that is capable of producing one or more biomass-degrading enzymes and that exhibits increased or decreased expression or copy number of a polynucleotide encoding a ptab-like protein. Also provided is a fermentation processes for producing one or more biomass-degrading enzymes comprising a fungal cells exhibiting increased or decreased expression or copy number of a polynucleotide encoding a ptab-like protein.
10/02/14
20140295493
Polypeptides having protease activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
10/02/14
20140295489
Organic compounds
The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake..
10/02/14
20140295454
Variants of vegfr and their use in the diagnosis and treatment of pregnancy associated medical conditions
An isolated polypeptide comprising an amino acid sequence at least 70% homologous to seq id no: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which specifically binds the isolated polypeptide are also disclosed.
10/02/14
20140295443
Polynucleotide sequences of candida dubliniensis and probes for detection
The present invention relates to identification of centromeric sequences of candida dubliniensis and localization of cdcse4p centromeric histone to the identified region. Also the present invention relates to distinguishing candida dubliniensis from other members of genus candida..
10/02/14
20140295439
Nucleic acid amplification
Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
10/02/14
20140295415
Low cost, disposable molecular diagnostic devices
The invention provides molecular diagnostic test devices and methods for using such diagnostic test devices to detect analytes of biological significance in a patient. The diagnostic test devices are particularly useful for detecting a polynucleotide analyte in a sample obtained from a patient.
10/02/14
20140295408
Compositions, methods, and kits for nucleic acid hybridization
Polynucleotides having a first polynucleotide segment contiguous with a second polynucleotide segment that is downstream to the first, wherein the sequence of the first polynucleotide segment is complementary to the sequence of a first probe segment of a probe for detection of a target nucleic acid sequence, wherein the sequence of the second polynucleotide segment is complementary to the sequence of a second probe segment of the probe, wherein the second probe segment is downstream to the first probe segment, are provided. The polynucleotides may be employed with dual-labeled probes (dlps) in assays for the detection of the target nucleic acid sequences..
10/02/14
20140295027
Polypeptides having protease activity
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides in e.g.
10/02/14
20140294848
Novel targets for regulation of angiogenesis
The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of angiogenesis and the diagnosis and treatment of angiogenesis-related diseases such as cancer..
10/02/14
20140294837
Fusion protein comprising anti-c-met antibody and vegf-binding fragment
There are provided a fusion protein formed by coupling of anti-c-met antibody and vegf-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-met and vegf at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-met antibody with a vegf-binding fragment.. .
10/02/14
20140294821
Factor viii chimeric and hybrid polypeptides, and methods of use thereof
The present invention provides methods of administering factor viii (processed fviii, single chain fviii, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising factor viii; chimeric and hybrid polypeptides comprising factor viii; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells. .
10/02/14
20140294782
Reprogramming of cellular adhesion
Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds and compositions in research and therapeutic applications..
09/25/14
20140289908
Gene combinations for producing punicic acid in transgenic plants
Transgenic plants with enhanced punicic acid accumulation result from over-expression of pgfadx and pgfad2, and optionally, one or more of pgdgat1, pgdgat2, and pgpdat1. The invention also relates to novel isolated punica granatum diacylglycerol acyltransferases: type 1 (pgdgat1), type 2 (pgdgat2) and phospholipid:diacylglycerol acyltransferases (pgpdat1); polynucleotide sequences encoding the dgats and pdat enzymes; polynucleotide constructs, vectors and host cells incorporating the polynucleotide sequences; and methods of producing and using same..
09/25/14
20140289906
Compositions having dicamba decarboxylase activity and methods of use
Compositions and methods comprising polynucleotides and polypeptides having dicamba decarboxylase activity are provided. Further provided are nucleic acid constructs, host cells, plants, plant cells, explants, seeds and grain having the dicamba decarboxylase sequences.
09/25/14
20140289905
Polypeptides having xylanase activity and polynucleotides encoding same
Provided are isolated polypeptides having xylanase activity, catalytic domains and cellulose binding domains, and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains..
09/25/14
20140289901
Modulating beta-damascenone in plants
A mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a neoxanthin synthase and having at least 60% sequence identity to seq id no:1 or seq id no. 6; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide having at least 66% sequence identity to seq id no:2 or at least 60% sequence identity to seq id no.
09/25/14
20140289900
Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
Provided are isolated polynucleotides at least 80% identical to seq id nos: 1-479, 813-5173, 8511, 8513, 8515, 8517, 8519, 8521, 8523, 9096-9141 and 9142; and isolated polypeptides at least 80% homologous to an amino acid sequence selected from the group consisting of seq id nos: 624, 480-623, 625-812, 5174-7015, 7017-7021, 7024, 7026-8510, 8512, 8514, 8516, 8518, 8520, 8522, 8524, 9143-9177, such as the polypeptides set forth in seq id no:480-812, 5174-8510, 8512, 8514, 8516, 8518, 8520, 8522, 8524, and 9143-9177, nucleic acid constructs comprising same, transgenic cells and plants expressing same and methods of using same for increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, nitrogen use efficiency, and/or abiotic stress tolerance of a plant.. .
09/25/14
20140289881
Double-stranded rna
The present disclosure provides methods and compositions relating to a polynucleotide comprising a dsrna region that is complementary to a particular region of the ns1 gene segment in the influenza virus genome that targets a sequence comprising two overlapping reading frames, one encoding ns1 and the second encoding the nep polypeptide. Thus, the polynucleotide of the invention is able to target two message rnas and is effective at inhibiting the replication of influenza virus in a cell..
09/25/14
20140288164
Treatment of autoimmune diseases
Compositions can be used to stimulate growth of a hair shaft from a hair follicle. These compositions can include methylated polynucleotides useful in treatment of autoimmune diseases or conditions, including those, such as alopecia areata, that result in hair loss..
09/25/14
20140288160
Cleavable lipids
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids..
09/25/14
20140288153
Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an antiviral gene, in particular, by targeting natural antisense polynucleotides of an antiviral gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of antiviral genes..
09/25/14
20140288152
Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of ‘c terminus of hsp70-interacting protein’ (chip), in particular, by targeting natural antisense polynucleotides of ‘c terminus of hsp70-interacting protein’ (chip). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of chip..
09/25/14
20140287991
Hepatitis b virus-binding polypeptides and methods of use thereof
The present invention provides non-naturally occurring polypeptides that specifically bind hepatitis b virus (hbv) dna; and polynucleotides encoding the polypeptides. The present invention further provides methods of detecting hbv dna; methods of detecting a covalently closed circular dna (cccdna) form of hbv; and methods for treating hbv infection..
09/25/14
20140287465
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to polypeptides having xylanase activity, catalytic domains, and carbohydrate binding domains, and polynucleotides encoding the polypeptides, catalytic domains, and carbohydrate binding domains. The present invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains, and carbohydrate binding domains..
09/25/14
20140287454
Susceptibility to selective cdk9 inhibitors
The present invention relates to a method of selecting (a) cell(s), (a) tissue(s) or (a) cell culture(s) with susceptibility to a selective cdk9 inhibitor. Also a method for determining the responsiveness of a mammalian tumor cell or cancer cell to treatment with a selective cdk9 inhibitor is described herein.
09/25/14
20140287419
Compositions having dicamba decarboxylase activity and methods of use
Compositions and methods comprising polynucleotides and polypeptides having dicamba decarboxylase activity are provided. Further provided are nucleic acid constructs, host cells, plants, plant cells, explants, seeds and grain having the dicamba decarboxylase sequences.
09/25/14
20140287410
Probe:antiprobe compositions for high specificity dna or rna detection
Probe systems and methods are provided for detecting nucleic acid targets using labeled polynucleotide probes and antiprobes that interact together and with complementary targets. These interactions result in signaling changes that indicate target frequency and provide error-checking functions that facilitate single base discrimination.
09/25/14
20140286982
Multimeric multiepitope influenza vaccines
An isolated polynucleotide encoding an influenza multi-epitope polypeptide, wherein the multi-epitope polypeptide comprises multiple copies of a plurality of influenza virus peptide epitopes wherein the polypeptide is b(x1zx2z . .
09/25/14
20140286980
Infectious clones of torque teno virus
The present invention is directed to novel nucleotide and amino acid sequences of torque teno virus (“ttv”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine ttv genotypes and isolates.
09/25/14
20140286954
Tau protease compositions and methods of use
Disclosed are mammalian tau proteases, as well as proteolytically-active fragments, variants, and mutants thereof. Also disclosed are polynucleotides and recombinant expression vectors that encode these polypeptides, as well as methods for producing such proteins in selected recombinant host cells, and for using the compositions in a variety of diagnostic and analytical assays..
09/25/14
20140286905
Recombinant adenovirus comprising trans-splicing ribozyme and cancer-treating gene, and use thereof
The present invention relates to: a recombinant adenovirus comprising a polynucleotide, which encodes a trans-splicing ribozyme-hsvtk composite relating to a cancer-specific gene, and a cancer-treating gene; a pharmaceutical composition for preventing or treating cancer, containing the recombinant adenovirus as an active ingredient; and a method for treating cancer, comprising the step of administering the recombinant adenovirus or the pharmaceutical composition to an individual requiring treatment. The recombinant adenovirus of the present invention shows selectivity for a cancer cell by a trans-splicing ribozyme relating to a cancer-specific gene and an increased anticancer activity by a cancer-treating gene, and thus can be widely used for the effective prevention and treatment of cancer..


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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