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Polynucleotide patents

      

This page is updated frequently with new Polynucleotide-related patent applications.




new patent Method of preparing libraries of template polynucleotides
The present invention relates to a method for preparing a library of template polynucleotides and use thereof in methods of solid-phase nucleic acid amplification. More specifically, the invention relates to a method for preparing a library of template polynucleotides that have common sequences at their 5′ ends and at their 3′ ends..
Illumina Cambridge Limited


new patent Methods of detecting target nucleic acids
The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification.
Applied Biosystems Llc


new patent Multitag sequencing ecogenomics analysis
Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis.
Biospherex, Llc


new patent Polynucleotides and polypeptides involved in post-transcriptional gene silencing
This invention relates to isolated nucleic acid fragments encoding polypeptides involved in post-transcriptional gene silencing. The invention also relates to construction of a recombinant dna construct encoding all or a portion of the polypeptide involved in post-transcriptional gene silencing, in sense or antisense orientation, wherein expression of the recombinant dna construct results in production of altered levels in a transformed host cell of the the polypeptide involved in post-transcriptional gene silencing..
E I Du Pont De Nemours And Company


new patent Organic compounds
The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake..

new patent Prokaryotic rnai-like system and methods of use
Provided herein are methods for inactivating a target polynucleotide. The methods use a psirna having a 5′ region and a 3′ region.
University Of Georgia Research Foundation, Inc.


new patent Polypeptides having protease activity
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides in, e.g., animal feed and detergents..
Novozymes A/s


new patent Endonucleases
The present invention provides an endonuclease i or enzymatically active fragment thereof wherein said endonuclease i has the sequence of seq id no. 4 or a sequence which is at least 70% identical thereto and wherein the amino acid residue which is immediately n-terminal of the fycgc pentapeptide motif has been substituted with a residue which is negatively charged as well as nucleic acid molecules encoding these enzymes and methods of removing contaminating polynucleotides from a sample using these enzyme..
Biotec Pharmacon Asa


new patent Cutinase variants and polynucleotides encoding same
Variants with cutinase activity of a parent cutinase, comprising an alteration at one or more (e.g. Several) positions corresponding to positions: 181, 182, 115, 161, 1, 2, 43, 55, 79, or 5 of seq id no: 2, wherein the alteration is a substitution for positions 181, 115, 161, 43, 55, 79, and 5, and a deletion for positions 1, 2 and 182, and wherein the variant has at least 75% but less than 100% sequence identity to the mature polypeptide of seq id no: 2.
Novozymes A/s


new patent Surface, anchored fc-bait antibody display system
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell.

new patent

Disulfide-linked reversible terminators

The present disclosure provides methods of sequencing polynucleotides and compounds, compositions useful for sequencing of polynucleotides. The chemical compounds include nucleotides and their analogs which possess a sugar moiety comprising a cleavable chemical group capping the 3′-oh group and a base that is attached to a detectable label through a cleavable linker comprising a disulfide bond.
Centrillion Technology Holdings Corporation

Methods for diagnosing diseases associated with human signal peptide-containing molecules

The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
Incyte Corporation

Novel reporter constructs for compound screening

The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a dna sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the dna sequence-specific transactivator.
Koch Biological Solutions, Llc

Compositions and methods for preparing sequencing libraries

Compositions comprising activated topoisomerase adaptors (topo-adaptors) and methods of using the activated topo-adaptors are provided for preparing a library of target dna duplexes derived from sample polynucleotides (e.g., dna, rna) for the streamlined preparation of a large number of samples. Such libraries may be used for next generation sequencing (ngs)..
Molecular Cloning Laboratories (mclab) Llc

Universal probe assay methods

Reagents and methods are provided for detecting the presence of a target polynucleotide in a sample are disclosed. In one aspect, a method for producing a labeled amplification product by amplifying a target nucleic acid sequence to produce an amplification product comprising the target sequence, a first probe-binding sequence 5′ to the target sequence, and a second probe-binding sequence 3′ to the target sequence, thereby producing an amplification product; and hybridizing a first detection probe to the amplification product, the first detection probe comprising a first segment that hybridizes to the first probe-binding sequence and a second segment that hybridizes to the second probe-binding sequence, thereby producing a labeled amplification product is disclosed..
Fluidigm Corporation

Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield, biomass, oil content and/or growth rate

Provided are isolated polynucleotides which comprise a nucleic acid sequence encoding a polypeptide which exhibits at least 94% sequence identity to seq id no: 333, and nucleic acid constructs, plants and methods of using same for increasing a yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.. .
Evogene Ltd.

Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants

Provided are method of increasing oil content, growth rate, biomass, yield and/or vigor of a plant. The methods are effected by upregulating in the plant an expression level of a polypeptide comprising an amino acid sequence at least 90% homologous to the amino acid sequence selected from the group consisting of seq id nos: 199, 166-198, 200-221, 229-307, 311-330, 351-353, 355-361, 363-364, 366-368, 218, 222-228, 308-310, 350, 354, 362, 365, 523-649, 786-920, 1047 and 1048.
Evogene Ltd.

Soybean atps promoter and its use in constitutive expression of transgenic genes in plants

The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean atp sulfurylase (atps) and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a tissue-independent or constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E I Du Pont De Nemours And Company

Alpha-amylase variants and polynucleotides encoding same

The present invention relates to variants having alpha-amylaseactivity and polynucleotides encoding the variants. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the variants..
Novozymes A/s

Method of screening lactate dehydrogenase mutant, lactate dehydrogenase mutant, polynucleotide, vector, microorganism including the mutant, and producing lactate using the microorganism

A method of screening a microorganisim having a mutant lactate dehydrogenase with increased activity, a mutant lactate dehydrogenase polypeptide, a polynucleotide and vector encoding same, and a microorganism that expresses the lactate dehydrogenase mutant, and a method of producing lactate using the microorganism.. .
Samsung Electronics Co., Ltd.

Antibodies that bind novel pcsk9 variants

The present invention provides novel polynucleotides encoding pcsk9b and pcsk9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides.
Bristol-myers Squibb Company

Antibodies against ox40 and uses thereof

Provided herein are antibodies, or antigen binding portions thereof, that bind to ox40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer.
Bristol-myers Squibb Company

Polynucleotides encoding an actriib antibody

The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to actriib and uses for same.. .
Dyax Corp.

Prostate specific membrane antigen (psma) bispecific binding agents and uses thereof

Provided herein are isolated cd3×psma-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a fn3 domain specifically binds human prostate specific membrane antigen (psma) and a second antigen-binding site immunospecifically binds cd3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins.
Janssen Biotech, Inc.

Antibodies against f glycoprotein of hendra and nipah viruses

The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit hendra or nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the f glycoprotein of hendra or nipah virus, and pharmaceutical compositions including such antibodies and/or fragments.
The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc.

Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer

This invention relates to ly6g6f, vsig10, tmem25 and lsr proteins, which are suitable targets for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders, and drug development. This invention further relates to soluble ly6g6f, vsig10, tmem25 and lsr molecules, extracellular domains of ly6g6f, vsig10, tmem25 and lsr and conjugates, which are suitable drugs for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders.
Compugen Ltd.

Homogeneous preparations of il-31

Homogeneous preparations of human and murine il-31 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity..
Zymogenetics, Inc.

Nucleotide sequence and pharmaceutical composition based thereon with prolonged vegf transgene expression

A nucleic acid or transgene comprising a modified vegf 3′-untranslated region (3′-utr) polynucleotide sequence and a polynucleotide sequence encoding a vascular endothelial growth factor (vegf). When transformed into a host cell, the nucleic acid or transgene exhibits a high stability and provides prolonged and reliable expression of vegf.
"nextgen" Company Limited

Factor ix polypeptides and methods of use thereof

The present invention provides methods of administering factor ix; methods of administering chimeric and hybrid polypeptides comprising factor ix; chimeric and hybrid polypeptides comprising factor ix; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.. .
Biogen Hemophilia Inc.

Method to induce neovascular formation and tissue regeneration

The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (vegf), or that encodes a polypeptide comprising an active site of the vegf. The coding sequence is operably linked to an expression control sequence; and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte.
Fundacion Universitaria Dr. Rene G. Favaloro

Intrapulmonary administration of polynucleotide toll-like receptor 9 agonists for treating cancer of the lung

The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof.
Dynavax Technologies Corporation

Polypeptide for hydrolytic cleavage of zearalenone and/or zearalenone derivatives, isolated polynucleotide thereof as well as a polypeptide containing an additive, use of same as well as a process

The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of seq id no: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide..
Erber Aktiengesellschaft

Peptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides

The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of basic proline-rich lacrimal protein (bplp) or of any of its maturation products, by detecting, or quantifying in a biological sample of a test subject, a bplp protein or a maturation product thereof, and comparing the production of bplp protein or maturation product with the production of the same in a biological sample of a control subject. .
Institut Pasteur

Targeted gene delivery for dendritic cell vaccination

Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (dc). The virus envelope comprises a dc-sign specific targeting molecule.
California Institute Of Technology

Enhanced nucleic acid constructs for eukaryotic gene expression

The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors further comprise novel transposons and transposases that further improve expression.
Dna2.0, Inc.

Nov mini-promoters

Isolated polynucleotides comprising a nov mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, including, but not limited to, reporter genes, genes encoding a polypeptide of interest, and regulatory rna sequences such as mirna, sirna, and anti-sense rna.
The University Of British Columbia

Sorghum-derived transcription regulatory elements predominantly active in root hair cells and uses thereof

Transcription regulatory elements, namely promoter and terminator sequences, obtained from sorghum bicolor that drive rna transcription predominately in root hair cells are described, as well as cassettes, expression vectors, and genetically modified plants containing these transcription regulatory elements. The genetically modified plants can be gymnosperms, dicots, or monocots.
The United States Of America, As Represented By The Secretary Of Agriculture

Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf

Oligonucleotide compounds modulate expression and/or function of vascular endothelial growth factor (vegf) polynucleotides and encoded products thereof. Methods for treating diseases associated with vascular endothelial growth factor (vegf) comprise administering one or more oligonucleotide compounds designed to inhibit the vegf natural antisense transcript to patients..
Curna, Inc.

Peptides derived from gse 24.2 for treating diseases caused by oxidative stress and damage to dna

This invention relates to a polypeptide which comprises the fragment seq id no. 2 of peptide gse24.2 (seq id no.
Centro De InvestigaciÓn BiomÉdica En Red (ciber)

Delivery of packaged rna to mammalian cells

Described herein are compositions relating to alphavirus-based virus-like particles (vlps) and methods for making and using the described vlps. The described compositions include vlps and vectors and cells used to produce the vlps.
The Usa , As Represented By The Secretary, Dept. Of Health And Human Services

Interleukin-10 fusion proteins and uses thereof

The present invention generally relates to fusion proteins of antibodies and interleukin-10 (il-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides.
Roche Glycart Ag

Rna monomers containing o-acetal levulinyl ester groups and their use in rna microarrays

The present invention is directed to rna monomers comprising o-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or rna polynucleotides.
Wisconsin Alumni Research Foundation

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of dna, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g.
California Institute Of Technology

Wound healing compositions and treatments

This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase..
Coda Therapeutics, Inc.

Gene defects and mutant alk kinase in human solid tumors

Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of anaplastic lymphoma kinase (alk) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. Non-small cell lung carcinoma (nsclc).
Cell Signaling Technology, Inc.

Systems and methods to detect rare mutations and copy number variation

The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference.
Guardant Health, Inc.

Microparticle containing nucleic acid capture probes and use

A method of identifying alleles of polymorphic sites in a plurality of nucleic acid samples including the steps of determining a source tag sharing number “d” for each of the alleles; performing a first reaction in a plurality of pools of the alleles to be identified to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products to identify the alleles. If “d” is equal to or larger than a maximum pool size, the first reaction may not be performed.
Bioinventors & Entrepreneurs Network, Llc

Yield improvement in plants

Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased yield, increased light use efficiency, increased photosynthetic capacity, increased photosynthetic rate, increased photosynthetic resource use efficiency, greater vigor, and/or greater biomass as compared to a control plant..
Koch Biological Solutions, Llc

Nucleotide sequence encoding homeobox-leucine zipper protein hat22 (hd-zip protein 22) from corchorus olitorius and corchorus capsularis and methods of use

The present invention relates to the isolated polynucleotide encoding homeobox-leucine zipper protein hat22 (hd-zip protein 22) from the plants corchorus olitorius and corchorus capsularis and corresponding polypeptide derived thereof. The present invention also relates to the plants having modulated expression of a nucleic acid encoding a homeobox-leucine zipper hat22 polypeptide or a homologue thereof, which has the ability to modify, preferably to increase/enhance, the fiber length, plant height, and/or plant biomass.
Bangladesh Jute Research Institute

Rack for sample tubes and reagent holders

A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples..
Handylab, Inc.

Variants of a family 44 xyloglucanase

The present invention relates to variants of a parent xyloglucanase. The present invention also relates to polynucleotides encoding the variant xyloglucanases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide..
Novozymes A/s

Enhanced nucleic acid constructs for eukaryotic gene expression

The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors further comprise novel transposons and transposases that further improve expression.
Dna2.0, Inc.

Conditionally replicating adenovirus

The present invention provides a polynucleotide, which comprises human telomerase reverse transcriptase (htert) promoter, e1a gene, ires sequence and e1b gene in this order and which comprises a target sequence of a first mirna. The present invention also provides a recombinant adenovirus, which comprises a replication cassette comprising the above polynucleotide, wherein the replication cassette is integrated into the e1 region of the adenovirus genome..

Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish

The present invention relates to a new generation of chimeric antigen receptors (car), under single-chain or multi-chain forms, the specificity of which, to a desired antigen, is conferred by a vnar polypeptide derived from monomeric antibodies from cartilaginous fish. Such cars, which aim to redirect immune cell specificity toward selected undesired malignant cells, are compact and thus particularly adapted to target hollow antigens such as ions channels of efflux pumps present at the surface of drug-resistant cells.
Cellectis

Antigen binding proteins

The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid p component (sap), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, alzheimer's disease, and type 2 diabetes..
Glaxo Group Limited



Polynucleotide topics:
  • Nucleotide
  • Polynucleotide
  • Polypeptide
  • Antagonist
  • Nucleic Acid
  • Cancer Cell
  • Drug Resistance
  • Chromosome
  • Glycoprotein
  • Gastrointestinal
  • Gastrointestinal Stromal Tumors
  • Gastrointestinal Stromal Tumor
  • Cellobiohydrolase
  • Human Disease
  • Inflammation


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    This listing is a sample listing of patent applications related to Polynucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Polynucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.


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