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Polynucleotide

Polynucleotide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for editing a genetic sequence
Regents Of The University Of Minnesota
June 22, 2017 - N°20170175143

This disclosure describes methods, polynucleotides, cells, compositions, and treatment methods that involve channeling a genomic nucleotide sequence. Generally, the method includes introducing a donor polynucleotide and a nucleotide that encodes an enzyme that cuts at least one strand of dna into a cell that has a genomic sequence in need of editing, allowing the enzyme to cut at least one ...
Pesticidal genes and methods of use
Agbiome, Inc.
June 22, 2017 - N°20170175134

Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the polypeptides, dna constructs and vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the polypeptides. Polynucleotide sequences encoding the polypeptides can be used in dna constructs or ...
Compositions and methods for the suppression of target polynucleotides from lepidoptera
E I Du Pont De Nemours And Company
June 22, 2017 - N°20170175133

Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable ...
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Libraries of nucleic acids and methods for making the same
Gen9, Inc.
June 22, 2017 - N°20170175110

Methods for designing and producing non-random libraries of nucleic acids are presented. In particular, synthesis of nonrandom libraries by multiplexed polynucleotide synthesis is utilized. Each library member may encode a promoter, ribosomal binding site and polypeptide.
Enzyme variants and polynucleotides encoding same
Novozymes A/s
June 22, 2017 - N°20170175098

The present invention relates to enzyme variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; methods of using the variants and composition comprising variants.
Cellobiohydrolase variants and polynucleotides encoding same
Novozymes, Inc.
June 22, 2017 - N°20170175097

The present invention relates to variants of a parent cellobiohydrolase ii. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
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Polynucleotide Patent Applications
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Polypeptides having glucoamylase activity and polynucleotides encoding same
Novozymes A/s
June 22, 2017 - N°20170175095

The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Engineered transaminase polypeptides for industrial biocatalysis
Codexis, Inc.
June 22, 2017 - N°20170175090

The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.
Enone reductases
Codexis, Inc.
June 22, 2017 - N°20170175087

The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
Polypeptides having endoglucanase activity
Novozymes A/s
June 22, 2017 - N°20170175047

The present invention relates to endoglucanases having xanthan degrading activity and polynucleotides encoding the endoglucanases. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the endoglucanases.
Bispecific t cell activating antigen binding molecules
Hoffmann-la Roche Inc.
June 22, 2017 - N°20170174786

The present invention generally relates to novel bispecific antigen binding molecules for t cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and ...
Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same
Ligand Pharmaceuticals, Inc.
June 22, 2017 - N°20170174770

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.
Anti-cgrp compositions and use thereof
Alderbio Holdings Llc
June 22, 2017 - N°20170174754

The present invention is directed to antibodies and fragments thereof having binding specificity for cgrp. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the vh, vl and cdr polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-cgrp antibodies and binding fragments thereof conjugated ...
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Polynucleotide Patent Applications
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Cytotoxic t lymphocyte inducing immunogens for prevention treatment and diagnosis of cancer
Immunotope, Inc.
June 22, 2017 - N°20170173135

The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as pancreatic carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a ctl response against pancreatic and other cancers.
Targeted adaptive vaccines
Moderna Tx, Inc.
June 22, 2017 - N°20170173128

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules for targeted adaptive vaccines (tavs).
Targeted disruption of the mhc cell receptor
Sangamo Biosciences, Inc.
June 22, 2017 - N°20170173080

Disclosed herein are methods and compositions for inactivating mhc genes, using zinc finger nucleases (zfns) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding zfns, vectors comprising polynucleotides encoding zfns and cells comprising polynucleotides encoding zfns and/or cells comprising zfns are also provided.
Anti-folate receptor alpha antibodies and uses thereof
Eisai R&d Management Co., Ltd.
June 15, 2017 - N°20170168078

Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, ...
Methods for detecting nucleic acid fragments
Bio-id Diagnostic Inc.
June 15, 2017 - N°20170166954

Provided are methods for detecting and analyzing polynucleotides in a biological sample or sample derived therefrom for example, using a synthetic template polynucleotide. In some aspects, a target polynucleotide in the sample hybridizes to the template polynucleotide and is extended by a polymerase, generating an extended target polynucleotide. In some examples, the extended target polynucleotide is amplified, for example, by ...
Isolated polynucleotide including promoter region, host cell including the same, and method of expressing target ...
Samsung Electronics Co., Ltd.
June 15, 2017 - N°20170166944

Provided is a recombinant polynucleotide including a promoter region derived from an acetic acid-producing bacterium and a polynucleotide sequence encoding a target protein operably linked to the promoter, a host cell including the same, and a method of expressing a target gene or protein using the host cell.
Cotton transgenic event mon 88702 and methods for detection and uses thereof
Monsanto Technology Llc
June 15, 2017 - N°20170166922

The invention provides a transgenic gossypium hirsutum event mon 88702, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event mon 88702. The invention also provides polynucleotides specific for event mon 88702, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising polynucleotides for event mon 88702. The invention also provides methods related to event mon 88702.
Hppd variants and methods of use
Bayer Cropscience Ag
June 15, 2017 - N°20170166918

In the present invention, hppd enzymes and plants containing them showing a full tolerance against several classes of hppd-inhibitors are described. A set of hppd enzymes have been designed which have either no or only a significantly reduced affinity to hppd inhibitors and, at the same time, the rate of dissociation of the hppd inhibitors of the enzyme is increased ...
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