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 Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms patent thumbnailAcid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms
Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise.
Duke University


 Duplicating dna with contiguity barcodes for genome and epigenome sequencing patent thumbnailDuplicating dna with contiguity barcodes for genome and epigenome sequencing
Provided herein are methods and devices for accurate sequencing and detection of epigenetic information from template polynucleotides. Also provided are methods for long-range strand displacement amplification of polynucleotides, microfluidic devices with selectively permeable barriers for multistep processing, and methods for polynucleotide amplification using the microfluidic devices..
The Regents Of The University Of California


 Engineered cleavage half-domains patent thumbnailEngineered cleavage half-domains
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence..
Sangamo Biosciences, Inc.


 Engineering neural stem cells using homologous recombination patent thumbnailEngineering neural stem cells using homologous recombination
Described herein are recombinant polynucleotide-binding polypeptides, recombinant fusion proteins made with the described polynucleotide-binding polypeptides, methods of using the described recombinant polynucleotide-binding polypeptides and recombinant fusion proteins to modify genomic dna of cells and, in some embodiments, create recombinant cells. Methods are also provided herein for genetically modifying a neuronal stem cell.
The United States Of America, As Represented By The Secretary, Department Of Health & Human


 Drought tolerant plants and related constructs and methods patent thumbnailDrought tolerant plants and related constructs and methods
Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ring-h2 polypeptide..
Pioneer Hi-bred International, Inc.


 Soy nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement patent thumbnailSoy nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
Monsanto Technology Llc


 Methods and compositions for multiplex rna guided genome editing and other rna technologies patent thumbnailMethods and compositions for multiplex rna guided genome editing and other rna technologies
The invention includes materials and methods to generate numerous small rnas from one polynucleotide construct (synthetic gene) to facilitate rna-guided multiplex genome editing, modification, inhibition of expression and other rna-based technologies. The synthetic gene/polynucleotide construct encodes polycistronic rna components separated by trnas, and preferably also includes regulatory components such as a promoter or terminator to form an expression cassette.
The Penn State Research Foundation


 Improved wound healing compositions and treatments patent thumbnailImproved wound healing compositions and treatments
This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase..
Coda Therapeutics, Inc.


 Enzymes having alpha  amylase activity and methods of making and using them patent thumbnailEnzymes having alpha amylase activity and methods of making and using them
The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided.
Basf Enzymes Llc


 Transaminase biocatalysts patent thumbnailTransaminase biocatalysts
The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. .
Codexis, Inc.


Biocatalysts and methods for the synthesis of armodafinil


The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(r)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (r)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess..
Codexis, Inc.


Tslp binding proteins


The present disclosure relates to tslp binding proteins, such as anti-tslp single variable domains, polynucleotides encoding such tslp binding proteins, pharmaceutical compositions and kits comprising said tslp binding proteins and methods of manufacture. The present invention also concerns the use of such tslp binding proteins in the treatment of diseases associated tslp signaling, such as asthma..
Glaxosmithkline Intellectual Property Development Limited


Variant activin receptor


The present invention provides variant activin iib soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin a, myostatin, or gdf-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins.
Amgen Inc.


Polynucleotide molecules and uses thereof


The present disclosure provides alternative nucleosides, nucleotides, and polynucleotides, and methods of use thereof.. .
Moderna Therapeutics, Inc.


Method for enhanced uptake of viral vectors in the myocardium


The present invention relates to improved therapies for the treatment of heart disease, particularly the improved delivery of therapeutic agents to heart tissue by direct infusion into the coronary circulation. A preferred embodiment of the invention is a method of treating or preventing a cardiovascular disease by transfecting cardiac cells of a large mammal, the method comprising, identifying a mammal in need of treatment or prevention of heart disease, supplying no to the coronary circulation prior to, and/or during the infusion of a therapeutic polynucleotide into a blood vessel of the coronary circulation in vivo, where the therapeutic polynucleotide is infused into the blood vessel over a period of at least about three minutes, where the coronary circulation is not isolated or substantially isolated from the systemic circulation of the mammal; and where the therapeutic polynucleotide transfects cardiac cells of the animal resulting in the treatment or prevention of the heart disease..
Eiger Biopharmaceuticals, Inc.


Novel immunoconjugates


The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an fc domain and a single effector moiety.
Roche Glycart Ag


Coagulation factor-targeting to tlt-1 on activated platelets


The current invention relates to: procoagulant proteins which may, for example, be fusion proteins or chemical conjugates; methods of producing said procoagulant proteins; polynucleotides that encode said fusion proteins and cells that expresses them. Furthermore, the current invention relates to procoagulant proteins for use as a medicament.
Novo Nordisk A/s


Method for eliciting an immune response to human telomerase reverse transcriptase


The invention provides compositions and methods related to human telomerase reverse transcriptase (htrt), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers..
The Regents Of The University Of Colorado


Mesenchymal stem cells producing inhibitory rna for disease modification


Compositions and methods for delivering a sirna, dsrna, or mirna polynucleotide into a target cell comprising contacting the target cell with a mesenchymal stem cell, which mesenchymal stem cell comprises an exogenous dna sequence expressing the sirna or dsrna polynucleotide, thereby delivering the sirna, dsrna, or mirna polynucleotide to the target cell through a cellular protrusion or a microvesicle.. .
The Regents Of The University Of California


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Methods for detection of nucleotide modification


This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mc), 5-hydroxymethylcytosine (5hmc) and 5-formylcytosine (5fc) to be distinguished from cytosine (c) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence.

Glyphosate-n-acetyltransferase (glyat) sequences and methods of use


Compositions and methods comprising polynucleotides and polypeptides having glyphosate-n-acetyltransferase (glyat) activity are provided. In specific embodiments, the sequence has an improved property, such as, but not limited to, an improved specificity for glyphosate when compared to an appropriate control resulting in decreased off target acetylation of, e.g.
Pioneer Hi-bred International, Inc.


Regulatory elements from labyrinthulomycetes microorganisms


The present disclosure generally relates to novel polynucleotide molecules for use in regulating gene expression in recombinant cells, such as labyrinthulomycetes cells. The disclosure further relates to nucleic acid constructs, such as vectors and expression cassettes, containing a regulatory element operably linked to a heterologous nucleotide sequence.
Synthetic Genomics, Inc.


Polynucleotide constructs having disulfide groups


The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internucleotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene.
Solstice Biologics, Ltd.


Factor ix polypeptides and methods of use thereof


The present invention provides methods of administering factor ix; methods of administering chimeric and hybrid polypeptides comprising factor ix; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.. .
Biogen Hemophilia Inc.


Modified helicases


The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a dda helicase.
Oxford Nanopore Technologies Ltd.


Antibody therapeutics that bind jag1


There is disclosed compositions and methods relating to or derived from anti-jag1 antibodies. More specifically, there is disclosed fully human antibodies that bind jag1, jag1-binding fragments and derivatives of such antibodies, and jag1-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


Antibody therapeutics that bind tim3


There is disclosed compositions and methods relating to or derived from anti-tim3 antibodies. More specifically, there is disclosed fully human antibodies that bind tim3, tim3-antibody binding fragments and derivatives of such antibodies, and tim3-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


Antibody therapeutics that bind cd47


There is disclosed compositions and methods relating to or derived from anti-cd47 antibodies. More specifically, there is disclosed fully human antibodies that bind cd47, cd47-antibody binding fragments and derivatives of such antibodies, and cd47-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


Protoxin-ii variants and methods of use


The present invention relates to protoxin-ii variants, polynucleotides encoding them, and methods of making and using the foregoing.. .
Janssen Biotech, Inc.


Reactivation of axon growth and recovery in chronic spinal cord injury


Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using nogo receptor antagonists, including nogo receptor-1 (ngr1) polypeptides, nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble nogo receptors and fusion proteins thereof, and polynucleotides. Also disclosed are methods of noninvasively monitoring axonal growth during and after treatment with an axonal growth promoting agent..
Yale University


Agricultural uses of a novel bacterium of the genus streptomyces


A method for processing plant matter, which involves applying a processing composition including at least one biological agent selected from: bacteria including a dna sequence, referred to as 16s rdna, coding for the 16s ribosomal rna of the bacterium, which is 100% homologous with seq id no. 1, culture media in which bacteria have grown which include the 16s rdna sequence that is 100% homologous with seq id no.
Universite Paul Sabatier Toulouse Iii


Method of characterizing a target ribonucleic acid (rna) comprising forming a complementary polynucleotide which moves through a transmembrane pore


The invention relates to a new method of characterising a target ribonucleic acid (rna) involving forming a complementary polynucleotide. The method uses a transmembrane pore..
Oxford Nanopore Technologies Ltd.


Systems and methods to detect rare mutations and copy number variation


The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference.
Guardant Health, Inc.


A soybean u6 polymerase iii promoter and methods of use


The disclosure relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean u6 polymerase iii gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, mutated plants, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E.i. Du Pont De Nemours And Company


Promoters for expressing genes in a fungal cell


The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides encoding polypeptides. The present invention also relates to methods for producing such polypeptides..
Novozymes, Inc.


Aldolases, nucleic acids encoding them and methods for making and using them


This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, hmg and/or khg aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, hmg and/or khg aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
Basf Enzymes Llc


Il-17 receptor a antigen binding proteins


The present invention relates to il-17 receptor a (il-17ra or il-17r) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by il-17 receptor a activation by one or more il-17 ligands. The present invention relates to the identification of neutralizing determinants on il-17 receptor a (il-17ra or il-17r) and antibodies that bind thereto.
Kirin-amgen, Inc.


Mycobacterial antigen composition


There is provided an antigenic composition comprising (a) a first mycobacterial antigenic polypeptide or a first mycobacterial polynucleotide; and (b) a second mycobacterial antigenic polypeptide or a second mycobacterial polynucleotide; wherein: (i) said first mycobacterial antigenic polypeptide comprises a polypeptide sequence having at least 70% amino acid sequence identity to the amino acid sequence of seq id no: 1 or 7, or a fragment thereof having at least 7 consecutive amino acids thereof; (ii) said first mycobacterial polynucleotide comprises a polynucleotide sequence encoding said first mycobacterial antigenic polypeptide; (iii) said second mycobacterial antigenic polypeptide comprises a polypeptide sequence having at least 70% amino acid sequence identity to the amino acid sequence of seq id no: 5, or a fragment thereof having at least 7 consecutive amino acids thereof; and (iv) said second mycobacterial polynucleotide comprises a polynucleotide sequence encoding said second mycobacterial polypeptide.. .
The Secretary Of State For Health


Compositions and methods for expressing recombinant polypeptides


Methods of expressing a recombinant polypeptide of interest are provided. Accordingly there is provided a method comprising providing a cell having been contacted with an agent which downregulates an expression of a tuberous sclerosis (tsc) protein or directly inhibits an activity of same; and contacting the cell with a polynucleotide encoding the recombinant polypeptide of interest.
Tel Hashomer Medical Research Infrastructure And Services Ltd.


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Integrated performing nucleic acid extraction and diagnostic testing on multiple biological samples


The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out pcr on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides..
Handylab, Inc.


Microfluidic cartridge


The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication with one another: an inlet; a first valve and a second valve; a first channel leading from the inlet, via the first valve, to a reaction chamber; and a second channel leading from the reaction chamber, via the second valve, to a vent..
Handylab, Inc.


Methods and devices for nucleic acid synthesis


Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides.
Gen9, Inc.


Long-acting coagulation factors and methods of producing same


Polypeptides comprising at least one carboxy-terminal peptide (ctp) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed..
Opko Biologics Ltd.


Composition for preventing or treating amyotrophic lateral sclerosis using two or more isoforms of hepatocyte growth factor


The present invention relates to a composition for preventing or treating amyotrophic lateral sclerosis, the composition containing, as an active ingredient, two or more isoforms of a hepatocyte growth factor (hgf) or a polynucleotide encoding the isoforms. The composition of the present invention is used to effectively prevent or treat amyotrophic lateral sclerosis..
Viromed., Ltd.


Self-reproducing hybrid plants


Compositions and methods for the production of self-reproducing hybrid plants are provided. Compositions include suppression cassettes encoding polynucleotides and promoters that result in the mime clonal diploid gamete phenotype compositions and suppression cassettes and expression cassettes useful for genome elimination of a parental diploid gamete in a fertilized zygote.
Pioneer Hi-bred International Inc.


High-throughput single-cell analysis combining proteomic and genomic information


Disclosed herein are methods for single-cell sequencing. In some examples, the methods include enriching a sample comprising a plurality of cells for cells of interest to produce an enriched cell sample; isolating one or more cells of interest in the enriched cell sample; and obtaining sequence information of one or more polynucleotides from each of the one or more isolated cells.
Becton, Dickinson And Company


Synthetic long read dna sequencing


The disclosure describes a method for sequencing long portions of dna sequence by assembling a plurality of shorter polynucleotide reads. Generally, the method includes annealing a plurality of primers to a denatured dna molecule, appending a barcode polynucleotide to the 5′ end of the primer, subjecting the dna molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5′ end of the primer, sequencing the barcode polynucleotides and the genomic dna, and assembling the short read polynucleotide sequences having identical barcode polynucleotides..
Stc.unm


Antibody libraries


The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.. .
Adimab, Llc


Regulated pepc expression


The present invention relates to a recombinant fungal host cell comprising at least one first polynucleotide encoding a polypeptide of interest; and one or more second polynucleotide encoding a fungal pepc protease, wherein the one or more second polynucleotide is operably linked to a regulated heterologous promoter, as well as a method for producing a polypeptide of interest, comprising cultivating said fungal host cell.. .
Novozymes A/s


Novel glycoside hydrolases from thermophlic fungi


The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof


The invention relates to the cloning, sequencing and characterization of the gene responsible for quorum quenching (qq) activity against quorum sensing (qs) signals of the tenacibaculum sp. Strain 20j (cect7426).
FundaciÓn Pedro BarriÉ De La Maza, Conde De Fenosa


Polypeptides having glucuronyl esterase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having glucuronyl esterase activity, catalytic domains and polynucleotides encoding the polypeptides or catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains..
Novoyzmes A/s


Polypeptides having peroxygenase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


Antibody therapeutics that bind cd137


There is disclosed compositions and methods relating to or derived from anti-cd137 antibodies. More specifically, there is disclosed fully human antibodies that bind cd137, cd137-antibody binding fragments and derivatives of such antibodies, and cd137-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


Use of endostatin peptides for the treatment of fibrosis


C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and polynucleotides are disclosed.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


Novel epitope for switching to th17 cell and use thereof


The present invention relates to a novel epitope to convert t cell to type 17 helper t (th17) cell. Specifically, the present invention relates to an epitope constituting the 41st to 50th amino acids (seq id no.
National Cancer Center


Polynucleotides encoding immune modulating polypeptides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.. .
Moderna Therapeutics, Inc.


Polynucleotides encoding low density lipoprotein receptor


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an ldlr signally enhancing mutation).. .
Moderna Therapeutics, Inc.


Cholera toxin a-like polypeptide useful as adjuvant component


A cholera toxin-like polypeptide useful as adjuvant is provided. polynucleotide coding to the polypeptide and associated vectors, host cells and methods of production are provided.
Gotovax Ab


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Polynucleotide compositions containing amino acids


The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.. .
Moderna Therapeutics, Inc.


Long poly(a) plasmids and methods for introduction of long poly(a) sequences into the plasmid


Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering the polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, and methods of enhancing transcription, translation, and increasing stability of a polynucleotide.. .
Seattle Children's Research Institute


Methods for treating cancers comprising k-ras mutations


Methods of inhibiting tumor growth, methods of treating cancer, and methods of reducing the frequency of cancer stem cells in a tumor are described. Particularly, the methods are directed to tumors or cancers that comprise a k-ras mutation.
Oncomed Pharmaceuticals, Inc.


Factor ix polypeptides and methods of use thereof


The present invention provides methods of administering factor ix; methods of administering chimeric and hybrid polypeptides comprising factor ix; chimeric and hybrid polypeptides comprising factor ix; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.. .
Biogen Hemophilia Inc.


Non-ribosomal protein synthesis pigment fusion peptides


The present invention relates to a polypeptide or polypeptide complex, comprising at least one non-ribosomal peptide synthesis (nrps) amino acid module functionally connected to at least one pigment module. The present invention further relates to a labeled oligopeptide comprising a non-naturally attached nrps pigment or/and polyketide pigment, to a polynucleotide encoding a fusion polypeptide, a vector, preferably an expression vector, comprising the polynucleotide of the present invention and to a host cell comprising the polypeptide or polypeptide complex and/or the polynucleotide, and/or the vector according to the present invention.
Ruprecht-karls-universität Heidelberg


Human cancer-related gene, its encoded products and applications


The invention discloses a human cancer-related gene, laptm4b, its encoded products and their applications thereof. This human cancer-related gene provided by this invention comprises one of the following nucleotide sequences: (1) seq id no: 1, seq id no: 2, seq id no: 3, seq id no: 6, or seq id no: 8 in the sequence listings; (2) polynucleotides that encode the protein sequences of seq id no: 4, seq id no: 5, or seq id no: 7 in the sequence listings; (3) dna sequences having above 90% homology with the dna sequences specified by seq id no: 1, seq id no: 2, seq id no: 3, seq id no: 6, or seq id no: 8 in the sequence listings, and these dna sequences encode the proteins with the same or similar functions.
Peking University


Genetic loci associated with resistance of soybean to cyst nematode and methods of use


Various compositions and methods are provided for identifying and selecting plants with enhanced resistance to soybean cyst nematode (scn). Further provided are transgenic plants, plant parts, and seed and methods of their use comprising a heterologous polynucleotide operably linked to a promoter active in the plant are provided, as are methods of making such plants and methods of use, wherein said heterologous polynucleotide comprises at least one, or any combination thereof, of glyma18g2580, glyma18g2590, glyma18g2600, glyma18g2610; and glyma18g2570 or an active variant or fragment thereof.
Pioneer Hi Bred International Inc


Native-extension parallel sequencing


The present invention provides methods for native extension parallel sequencing of polynucleotide.. .
Centrillion Technology Holdings Corporation


Soybean pip1 promoter and its use in constitutive expression of transgenic genes in plants


The disclosure relates to gene expression regulatory sequences from soybean, specifically to recombinant dna constructs comprising the promoter of a soybean plasma membrane intrinsic protein gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E. I. Du Pont De Nemours And Company


Modular rna regulators and methods


This disclosure describes modular mirna regulator molecules and methods of using modular mirna regulator molecules. Generally, the modular mirna regulator molecules include a recognition module and an inhibition module.
Stc.unm


Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


Polypeptides having cellobiohydrolase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


Antibody therapeutics that bind ctla4


There is disclosed compositions and methods relating to or derived from anti-ctla4 antibodies. More specifically, there is disclosed fully human antibodies that bind ctla4, ctla4-antibody binding fragments and derivatives of such antibodies, and ctla4-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


Polynucleotide molecules and uses thereof


The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.. .
Moderna Therapeutics, Inc.


Centrifuge and loading a device


An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array.
Life Technologies Corporation


Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations


An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating , where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.
Rensselaer Polytechnic Institute


Compositions and methods for controlling diabrotica


The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertevrate pest, for instance through rna interference..
Monsanto Technology Llc


Compositions and methods for controlling diabrotica


The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertebrate pest, for instance through rna interference..
Monsanto Technology Llc


Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use


Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Nidera S.a.


Polynucleotide encoding acyl-coa synthetase homolog and use thereof


The present invention relates to an acyl-coa synthetase homolog protein from microorganisms of the genus mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-coa synthetase homolog protein gene from, e.g., mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc..
Suntory Holdings Limited


Polynucleotide encoding acyl-coa synthetase homolog and use thereof


The present invention relates to an acyl-coa synthetase homolog protein from microorganisms of the genus mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-coa synthetase homolog protein gene from, e.g., mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc..
Suntory Holdings Limited


Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities


Isolated aspartyl-trna synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.. .
Atyr Pharma, Inc.


Modified beta-lactamases and methods and uses related thereto


Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.. .

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.


Glucoamylase variants and polynucleotides encoding same


The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


Microorganism with enhanced l-lysine productivity and producing l-lysine by using same


Provided are a beta prime subunit mutant of rna polymerase, a microorganism of the corynebacterium genus including a polynucleotide coding the same, and a method for producing l-lysine by culturing the same.. .
Cj Cheiljedang Corp.


Lucigen yellow (lucy), a yellow fluorescent protein


Described herein are isolated polynucleotides that encode a fluorescent protein which is at least 80% sequence identical to a protein selected from the group consisting of seq. Id.
Lucigen Corporation


Non-enzymatic, salt-mediated synthesis of polynucleic acids


Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid polymerase and lipids, but containing mononucleotides and a monovalent salt; (b) drying and resolubilizing the mixture of step (a) a plurality of times; and (c) recovering polynucleic acids from a resolubilized mixture of step (b). In certain aspects, the method further uses a low ph, e.g.
University Pierre And Marie Curie


Hypoxia-targeted delivery system for pharmaceutical agents


Molecular compositions, nanoparticle compositions, and pharmaceutical compositions of the invention provide for the delivery of a polynucleotide to a hypoxic cell or tissue. The compositions can also be used for the delivery a hydrophobic pharmaceutical agent, either alone or in combination with a polynucleotide, to a hypoxic cell or tissue.
Northeastern University


Single walled carbon nanotube polynucleotide complexes and methods related thereto


The present invention provides single-walled carbon nanotube formulations for the delivery of bioactive agents including large polynucleotides encoding therapeutic proteins into hard-to-transfect cells and methods of making such single-walled carbon nanotube formulations.. .
Ensysce Biosciences, Inc.


Test evaluating the risk of anti-thyroid drug-induced agranulocytosis, and evaluation kit


The present invention provides a test method and an evaluation kit for determining the risk of antithyroid drug-induced agranulocytosis. More particularly, it provides a test method for determining the risk of antithyroid drug-induced agranulocytosis, including testing susceptibility polymorphism to antithyroid drug-induced agranulocytosis, and determining the risk of antithyroid drug-induced agranulocytosis, and an evaluation kit for the risk of antithyroid drug-induced agranulocytosis, containing a polynucleotide capable of detecting susceptibility polymorphism to antithyroid drug-induced agranulocytosis..
Toyo Kohan Co., Ltd.


Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications


Techniques, methods, devices, and compositions are disclosed that are useful in identifying and sequencing natural and synthetic, and modified and unmodified dna, rna, pna, dna/rna nucleotides. The disclosed techniques, methods, devices, and compositions are useful in identifying various modifications, dna/rna damage, and nucleotide structure, using nanoelectronic quantum tunneling spectroscopy, which may be referred to as qm-seq.
The Regents Of The University Of Colorado, A Body Corporate


Nuclear targeting sequences


Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed..
Yeda Research And Development Co. Ltd.


Method of targeting gene delivery using viral vectors


Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus.
California Institute Of Technology


Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use


Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Nidera S.a.


Compositions for targeted delivery of sirna


The present invention is directed compositions for targeted delivery of rna interference (rnai) polynucleotides to hepatocytes in vivo. Targeted rnai polynucleotides are administered together with co-targeted delivery polymers.
Arrowhead Madison Inc.


Novel hydroxyphenylpyruvate dioxygenase polypeptides and methods of use


Novel hydroxyphenyl pyruvate dioxygenase (hppd) polypeptides, variants and fragments thereof, as as well as polynucleotides encoding the same, capable of conferring commercial levels of conferring hppd herbicide resistance or tolerance to plants. Compositions include amino acid sequences, and variants and fragments thereof, for hppd polypeptides, as well as polynucleotides encoding the same.
Syngenta Participations Ag


Albumin variants


The present invention relates to variants of a parent albumin; the variants comprise one or more mutations in domain ii of albumin which lead to a change in binding affinity to fcrn and/or a change in half-life compared to the “parent” albumin. The invention allows tailoring of binding affinity and/or half-life of an albumin to the requirements and desires of a user or application.
Novozymes Biopharma Dk A/s


Nano-constructs for polynucleotide delivery


The present invention provides novel nano-constructs useful for delivering polynucleotides into cells, methods of using the nano-constructs, and methods of making the nano-constructs.. .
The Chinese University Of Hong Kong


Sonogenic stimulation of cells


The invention provides compositions featuring trp-4 polypeptides and polynucleotides, methods for expressing such polypeptides and polynucleotides in a cell type of interest, and methods for inducing the activation of the trp-4 polypeptide in neurons and other cell types using ultrasound.. .
Salk Institute For Biological Studies


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Modified vasoactive intestinal peptides


The present invention provides modified vasoactive intestinal peptides (vips), encoding polynucleotides and vectors, as well as pharmaceutical compositions comprising the same. The invention further provides methods of making and using the modified vip agents.
Phasebio Pharmaceuticals, Inc.


Il-1beta-il-1ra chimera and methods of using the same


The present invention provides a chimera protein made of amino acid residues derived from il-1beta propeptide and the il-1ra mature peptide and polynucleotides encoding the protein. The present invention also provides usages of the protein and the polynucleotides in pharmaceutical compositions that treat inflammation..
The Regents Of The University Of Colorado, A Body Corporate




Polynucleotide topics:
  • Nucleotide
  • Polynucleotide
  • Polypeptide
  • Antagonist
  • Nucleic Acid
  • Cancer Cell
  • Drug Resistance
  • Chromosome
  • Glycoprotein
  • Gastrointestinal
  • Gastrointestinal Stromal Tumors
  • Gastrointestinal Stromal Tumor
  • Cellobiohydrolase
  • Human Disease
  • Inflammation


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