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Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
12/11/14
20140366223
 Methods for generating transgenic plants patent thumbnailMethods for generating transgenic plants
This invention provides a method for generating transgenic plants with a low copy number. Plant cells are transformed with polynucleotides containing transcriptional cassettes designed to trigger silencing of a gene which is essential for the plant cell to survive the transformation and regeneration process.
12/11/14
20140366218
 Soybean bb13 promoter and its use in embryo-specific expression of transgenic genes in plants patent thumbnailSoybean bb13 promoter and its use in embryo-specific expression of transgenic genes in plants
The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean bowman-birk type proteinase isoinhibitor gene (bbi3) and fragments thereof and their use in promoting the expression of one or more heterologous nucleotide sequences in an embryo-specific manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
12/11/14
20140364340
 Rationally designed, synthetic antibody libraries and uses therefor patent thumbnailRationally designed, synthetic antibody libraries and uses therefor
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences..
12/11/14
20140363852
 Methods and apparatus for synthesizing nucleic acids patent thumbnailMethods and apparatus for synthesizing nucleic acids
The invention provides improved methods for synthesizing polynucleotides, such as dna and rna, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.
12/11/14
20140363851
 Methods and apparatus for synthesizing nucleic acids patent thumbnailMethods and apparatus for synthesizing nucleic acids
The invention provides improved methods for synthesizing polynucleotides, such as dna and rna, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.
12/11/14
20140363561
 Tal-mediated transfer dna insertion patent thumbnailTal-mediated transfer dna insertion
The invention relates to methods for stably integrating a desired polynucleotide into a plant genome.. .
12/11/14
20140363538
 Use of polypeptides having protease activity in animal feed and detergents patent thumbnailUse of polypeptides having protease activity in animal feed and detergents
The present invention relates to the use of isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides in animal feed and detergents. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides in e.g.
12/11/14
20140363446
 Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics patent thumbnailPolypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against vsig1, ildr1, loc253012, ai216611, c1orf32 or fxyd3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages.
12/11/14
20140363415
 Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities patent thumbnailCompositions and methods comprising glycyl-trna synthetases having non-canonical biological activities
Isolated glycyl-trna synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.. .
12/11/14
20140360403
 Organic-inorganic composite materials as a result of biomineralization patent thumbnailOrganic-inorganic composite materials as a result of biomineralization
A method for producing organic-inorganic composite materials includes at least one biomineralising protein and/or polypeptide-encoding recombinant polynucleotide being introduced into at least one host cell, preferably from the class of slime moulds, and the expressed protein and/or polypeptide influencing the formation of inorganic particles in an extracellular matrix of the host cell.. .
12/04/14
20140357727
Fatty alcohol forming acyl reductase (far) variants and methods of use
The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides fatty acyl-coa reductase (far) variant enzymes, polynucleotides encoding the far variant enzymes, and vectors and host cells comprising polynucleotides encoding the far variant enzymes..
12/04/14
20140357566
Identification and molecular characterisation of proteins, expressed in the ixodes ricinus salivary glands
The invention relates to a new polynucleotide which encodes a polypeptide expressed in the salivary glands of ticks, more particularly the ixodes ricinus arthropod tick, during the slow-feeding phase of the blood meal have, said polynucleotide and related polypeptide may be used in different constructions and for different applications which are also included in the present invention.. .
12/04/14
20140356957
Biological pacemaker
Disclosed are methods and systems for modulating electrical behavior of cardiac cells. Preferred methods include administering a polynucleotide or cell-based composition that can modulate cardiac contraction to desired levels, i.e., the administered composition functions as a biological pacemaker..
12/04/14
20140356944
Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol
The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3′-hydroxyacetophenone to (s)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (s)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients..
12/04/14
20140356859
Detection of nucleic acids using unmodified gold nanoparticles
A gold nanoparticle-based colorimetric assay kit for nucleic acids from viral, bacterial and other microorganisms that detects unamplified or amplified polynucleotides in clinical specimens using unmodified aunps and oligotargeter polynucleotides that bind to a pathogen's nucleic acids. A method for detecting a pathogen comprising contacting a sample suspected of containing microbes with a polynucleotide that binds to pathogen nucleic acid and with gold nanoparticles, detecting the aggregation of nanoparticles, and detecting pathogen polynucleotides in the sample when the nanoparticles aggregate (solution color becomes blue) in comparison with a control or a negative sample not containing the virus when nanoparticles do not aggregate (solution color remains red)..
12/04/14
20140356363
Antigen binding proteins that bind pd-1
There is disclosed compositions and methods relating to or derived from anti-pd-1 antibodies. More specifically, there is disclosed fully human antibodies that bind pd-1, pd-1-binding fragments and derivatives of such antibodies, and pd-1-binding polypeptides comprising such fragments.
12/04/14
20140356355
Il-17 receptor a antigen binding proteins
The present invention relates to il-17 receptor a (il-17ra or il-17r) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by il-17 receptor a activation by one or more il-17 ligands. The present invention relates to the identification of neutralizing determinants on il-17 receptor a (il-17ra or il-17r) and antibodies that bind thereto.
12/04/14
20140356342
Human beta-adrenergic receptor kinase polypeptide and methods
Various embodiments of the invention provide human kinases and phosphatases (kpp) polypeptides and polynucleotides which identify and encode kpp. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists.
12/04/14
20140352706
Isopropylmalate synthase from nicotiana tabacum and methods and uses thereof
The present invention relates to a mutant, non-naturally occurring or transgenic plant cell comprising: (i) at least one polynucleotide comprising, consisting or consisting essentially of a sequence encoding an isopropylmalate synthase and having at least 60% sequence identity to seq id no:1 or seq id no:10 or seq id no: 12 or seq id no:14; or (ii) a polypeptide encoded by said polynucleotide(s); or (iii) a polypeptide having at least 60% sequence identity to seq id no:2 or seq id no:11 or seq id no:13 or seq id no:15; or (iv) a construct, vector or expression vector comprising said polynucleotide sequence(s), optionally wherein said construct, vector or expression vector additionally comprises a promoter comprising, consisting or consisting essentially of the sequence set forth in seq id no:8 or a variant thereof with at least about 60% identity thereto or a trichome promoter.. .
11/27/14
20140351998
Engineering plants for efficient uptake and utilization of urea to improve crop production
The present invention provides polynucleotides and related polypeptides related to urea uptake. The invention provides genomic sequences for urea transporter, urease and glutamine synthetase genes.
11/27/14
20140350077
Amphipathic co-oligomers for the delivery of sirna
Co-oligomer compounds, complexes of the same with polyanions, such as sirnas, and methods for using the same are provided. The delivery of polynucleotides, into a cell.
11/27/14
20140349946
Peptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides
The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of basic proline-rich lacrimal protein (bplp) or of any of its maturation products, by detecting, or quantifying in a biological sample of a test subject, a bplp protein or a maturation product thereof, and comparing the production of bplp protein or maturation product with the production of the same in a biological sample of a control subject. .
11/27/14
20140349929
Multivalent fibronectin based scaffold domain proteins
The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications.
11/27/14
20140349890
Multiplex amplification methods
Compositions and methods for amplifying selected polynucleotides, including dna and rna, particularly in multiplex amplification reactions using common primers amplification. Generally, methods of the invention employ multiple steps such as template-specific hybridization, a linear amplification, partial degradation of nucleic acid, and ligation.
11/27/14
20140349372
Lipase variants and polynucleotides encoding same
The present invention relates to lipase variants and methods of obtaining them. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
11/27/14
20140349349
Recombinant host cells comprising phosphoketolases
The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate, or acetyl-coa; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity..
11/27/14
20140349286
Exonuclease cycling assay
The present invention relates to a novel method for detecting a target polynucleotide having a target sequence, comprising hybridizing the target polynucleotide with a probe to form a hybrid; exposing the hybrid to a 5′ exonuclease so that the probe in the hybrid is digested and the target polynucleotide is dissociated from the digested probe; repeating the hybridization step and the digestion step; and detecting the digested probes. The presence of the digested probes indicates the presence of the target polynucleotide..
11/27/14
20140349285
Polymerase driven nesa
The present invention relates to a novel method for detecting a target polynucleotide having a target sequence, comprising (a) exposing the target polynucleotide to an initiating oligonucleotide; (b) extending the initiating oligonucleotide with an extended sequence complementary to the target sequence; (c) ligating the initiating oligonucleotide sequence with the extended sequence to form a circular oligonucleotide having a nicking endonuclease (ne) recognition/cutting sequence; (d) exposing the circular oligonucleotide to a dna polymerase and a dna synthesis primer to synthesize dna having a ne recognition sequence; (e) exposing the synthesized dna to a probe having the ne recognition/cutting sequence to form a double stranded dna having a full ne site; (f) exposing the double stranded dna to a nicking endonuclease (ne) to cleave the probe; and (g) detecting the cleaved probe. The presence of the cleaved probe indicates the presence of the target polynucleotide..
11/27/14
20140349276
Signal propagation biomolecules, devices and methods
This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains.
11/27/14
20140348849
Compounds and method for modulating inflammatory reactions
The present invention relates to compounds and methods for modulating, reducing or inhibiting, inflammatory reactions in a patient. Particularly, inflammatory reactions that are targeted by the present invention are cell migration, secretion of toxic products and proteolysis at a site of inflammation.
11/27/14
20140348827
Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof
The present invention provides variant activin iib soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin a, myostatin, or gdf-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins.
11/27/14
20140346059
Compositions, devices, systems, and methods for using a nanopore
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore.
11/20/14
20140344999
Family of pesticidal proteins and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided.
11/20/14
20140344998
Soybean atps promoter and its use in constitutive expression of transgenic genes in plants
The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean atp sulfurylase (atps) and fragments thereof and theft use in promoting the expression of one or more heterologous nucleic acid fragments in a tissue-independent or constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
11/20/14
20140344997
Polynucleotides encoding enzymes from the jute lignin biosynthetic pathway
Disclosed are polynucleotides encoding polypeptides that comprise the biosynthetic pathway for lignin in the jute plant. The present invention relates generally to the field of plant lignin biosynthesis genes, polypeptides encoded by such genes, and the use of such polynucleotide and polypeptide sequences for controlling plant lignin production.
11/20/14
20140343131
Compositions and methods for the suppression of target polynucleotides from lygus
Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the lygus genus, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant.
11/20/14
20140343120
Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases
Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as npra and nprc, or combinations of these therapies.
11/20/14
20140342992
Cell-penetrating peptides having a central hydrophobic domain
The present invention discloses cell penetrating peptides (cpp or membrane translocating peptide) and their conjugates with cargo molecules. The peptides are useful as drug delivery systems, particularly as delivery vehicles for nucleotide-based theraputics, such as polynucleotides, oligonucleotides and peptide nucleic acids.
11/20/14
20140342449
Method and device for producing and/or purifying polynucleotides and products obtainable thereof
An apparatus and a method for obtaining a (poly)nucleotide sequence of interest include steps of cultivating hosts cells to produce a nucleotide sequence of interest and harvesting these cells, introducing these cells in a passageway and disintegrating them in a continuous process. In the continuous process, performing in the passageway a precipitation of contaminants by a mixing of the disintegrated cells with a solution containing one or more salt(s) and obtaining a mixture and allowing a precipitate to separate from the solution of this mixture, preferably to float and/or to sediment from the solution of this mixture for 1-48 hours and pumping out a soluble material from this solution, while excluding recovering the precipitate..
11/20/14
20140342433
Subtilase variants and polynucleotides encoding same
The present invention relates to subtilase variants and methods for obtaining subtilase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
11/20/14
20140342422
Glucoamylase variants and polynucleotides encoding same
The present invention relates to glucoamylase variants having reduced sensitivity to protease nicking. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
11/20/14
20140342412
Biocatalysts and methods for the synthesis of substituted lactams
The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.. .
11/20/14
20140342410
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
11/20/14
20140342408
Polypeptides having xylanase activity and polynucleotides encoding same
Provided are isolated polypeptides having xylanase activity, catalytic domains and cellulose binding domains, and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains..
11/20/14
20140342354
Systems and methods for prenatal genetic analysis
The present disclosure provides for compositions and methods for the testing and analysis of genetic alterations of a sample comprising maternal and fetal polynucleotides. Generally, the composition and methods of this disclosure provide for the isolation of a mixture of maternal and fetal polynucleotides from a sample, generally from the mother.
11/20/14
20140341972
Method to induce neovascular formation and tissue regeneration
The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (vegf), or that encodes a polypeptide comprising an active site of the vegf. The coding sequence is operably linked to an expression control sequence; and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte.
11/20/14
20140341943
Ehrlichia ewingii proteins, nucleic acids, and methods of their use
The novel omp-1 gene cluster encoding twenty one ehrlichia ewingii (ee) proteins was isolated and sequenced completely. This invention relates to isolated e.
11/20/14
20140341914
Isolated mcpip and methods of use
A monocyte chemoattractant protein (mcp-1)-inducible protein, mcpip, its polynucleotide and amino acid sequences from mouse and human, and methods for its use are disclosed.. .
11/20/14
20140341897
Anti-folate receptor alpha antibodies and uses thereof
Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits.
11/20/14
20140341869
Chimeric receptors with 4-1bb stimulatory signaling domain
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1bb signaling domain.
11/13/14
20140338070
Methods and compositions for targeted integration in a plant
Compositions and methods are provided for the targeted integration of a polynucleotide sequence of interest into the genome of a plant or plant cell. The methods and compositions employ recognition sites for endonucleases and endonucleases in combination with site-specific recombination sites/recombinases to provide an effective system for establishing target sites within the genome of a plant, plant cell or seed.
11/13/14
20140336239
Compositions and methods for modulating myeloid derived suppressor cells
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (mdsc). In particular, described herein are mir-142 polynucleotides and mir-223 polynucleotides that can be used to modulate differentiation of mdscs.
11/13/14
20140336057
Method for pairwise sequencing of target polynucleotides
The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template..
11/13/14
20140335596
Subtilase variants and polynucleotides encoding same
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
11/13/14
20140335579
Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms
The present invention relates to polynucleotides from cochliobolus heterostrophus c5, cyanothece sp. Ccy0110, mycocentrospora acerin and hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids.
11/13/14
20140335573
Fusion proteins comprising type-ii cohesin modules, multi-enzyme complexes comprising same and uses thereof
Fusion proteins including a type-ii cohesin module that are capable of integrating into native and designer cellulosomes. β-glucosidases modified to include a type-ii cohesin module and polynucleotides encoding same.
11/13/14
20140335572
Polypeptides having catalase activity and polynucleotides encoding same
Provided are isolated polypeptides having catalase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
11/13/14
20140335570
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
11/13/14
20140335562
Genetically engineered herbicide resistant algae
Algae transformed with one or more polynucleotides encoding proteins that confer herbicide resistance are provided. The algae can be grown in small or large scale cultures that include one or more herbicides for the production and isolation of various products..
11/13/14
20140335512
Enzyme method
The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a recd helicase.
11/13/14
20140335068
Novel use of ec-sod for treating angiogenesis-mediated eye diseases
A method for treating an angiogenesis-mediated eye disease, includes administering to a subject in need thereof an effective amount of ec-sod protein, or a vector having a polynucleotide encoding the ec-sod protein, to treat angiogenesis-mediated eye diseases.. .
11/13/14
20140335067
Novel use of ec-sod and method for preparing thereof
A method for treating a disease, particularly asthma and anaphylactic shock, comprises administering to a subject in need thereof an effective amount of an ec-sod protein or a vector having a polynucleotide encoding thereof.. .
11/06/14
20140331364
Polypeptides having beta-glucosidase activity and polynucleotides encoding same
Provided are isolated polypeptides having beta-glucosidase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
11/06/14
20140331358
Regulatory polynucleotides and uses thereof
The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants.
11/06/14
20140329880
Exonuclease resistant polynucleotide and related duplex polynucleotides, constructs, compositions, methods and systems
Provided herein are exonuclease resistant polynucleotides and related constructs, compositions, methods and systems.. .
11/06/14
20140329775
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference
Disclosed herein are compositions and methods for generating ribo-nucleic neutral (rnn) or deoxyribo-nucleic-neutral (dnn) polynucleotides with reduced anionic charge, for improved intracellular delivery. Also disclosed herein are methods of using rnn and dnn compositions..
11/06/14
20140329698
Methods for indexing samples and sequencing multiple polynucleotide templates
The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like..
11/06/14
20140329293
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
11/06/14
20140329284
Chimeric polypeptides having beta-glucosidase activity and polynucleotides encoding same
The present invention relates to chimeric polypeptides having beta-glucosidase activity. The present invention also relates to polynucleotides encoding the chimeric polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the chimeric polypeptides.
11/06/14
20140329250
Calcium-binding photoprotein
The invention provides calcium-binding photoproteins which can detect light emission with a higher sensitivity. The proteins of the invention comprising the amino acid sequence of seq id no: 2 can be used for the detection and measurement of calcium ions.
11/06/14
20140329233
Methods, compositions and kits for a one-step dna cloning system
Methods and kits for joining two or more polynucleotides to form a product polynucleotide are provided. A mixture contains a first polynucleotide comprising a selectable marker.


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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