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Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
04/23/15
20150113668
 Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same patent thumbnailnew patent Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same
The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides..
Omt, Inc.
04/23/15
20150111957
 Endothelial cell-specific polynucleotides and use thereof patent thumbnailnew patent Endothelial cell-specific polynucleotides and use thereof
An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of hif-1alpha, the polypeptide being stably expressed and constitutively active. Isolated polypeptides encoded by same are also disclosed and uses thereof..
Vascular Biogenics Ltd.
04/23/15
20150111955
 Aav vector compositions and methods for gene transfer to cells, organs and tissues patent thumbnailnew patent Aav vector compositions and methods for gene transfer to cells, organs and tissues
The invention relates to adeno-associated virus (aav) serotype aav-rh74 and related aav vectors, and aav-rh74 and related aav vector mediated gene transfer methods and uses. In particular, aav-rh74 targets polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences..
The Children's Hospital Of Philadelphia
04/23/15
20150111282
 Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same patent thumbnailnew patent Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same
Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as seq id no: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.. .
Mogam Biotechnology Research Institute
04/23/15
20150111268
 Enzyme used in biosynthesis of 1, 4-bdo and screening  the same patent thumbnailnew patent Enzyme used in biosynthesis of 1, 4-bdo and screening the same
Recombinant butyraldehyde dehydrogenases (blds) with improved production of 1,4-bdo, as well as recombinant microorganisms comprising polynucleotides encoding the recombinant blds, and methods of producing 1,4-bdo by using the recombinant microorganisms.. .
Ajou University Industry-academic Cooperation Foundation
04/23/15
20150111260
 Aldolases, nucleic acids encoding them and methods for making and using them patent thumbnailnew patent Aldolases, nucleic acids encoding them and methods for making and using them
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, hmg and/or khg aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, hmg and/or khg aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
Cargill, Incorporated
04/23/15
20150111248
 In vivo production of proteins patent thumbnailnew patent In vivo production of proteins
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.
04/23/15
20150111197
 Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof patent thumbnailnew patent Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof
The present invention concerns wild-strains of chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions..
Institut Pasteur
04/23/15
20150110845
 Antimicrobial polynucleotide-templated metal nanocluster patent thumbnailnew patent Antimicrobial polynucleotide-templated metal nanocluster
There is provided a polynucleotide-templated metal nanocluster for use in therapy. There is also provided use of a polynucleotide-templated metal nanocluster in the manufacture of a medicament for prophylactically or therapeutically treating a microbial infection as well as a method of prophylactically or therapeutically treating a microbial infection comprising administering to a subject a polynucleotide-templated metal nanocluster.
Agency For Science, Technology And Research
04/23/15
20150110794
 Anti-human cytomegalovirus antibodies and use thereof patent thumbnailnew patent Anti-human cytomegalovirus antibodies and use thereof
This disclosure provides anti-human cytomegalovirus antibodies and methods of treatment, prophylaxis, detection, and diagnosis using the same. In another aspect, the disclosure features therapeutic, prophylactic, and/or diagnostic compositions for human cytomegalovirus infection or for a human cytomegalovirus-related disease that include a binding agent (e.g., antibody) or polynucleotide disclosed herein.
Cell Signaling Technology, Inc.
04/23/15
20150110785
new patent

Methods of impairing osteoclast differentiation using antibodies that bind siglec-15


This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding polypeptides, uses of the polynucleotides, polypeptides, variants and derivatives, and methods and compositions for the amelioration of symptoms caused by bone remodeling disorders. Disclosed in particular are the isolation and identification of polynucleotides, polypeptides, variants and derivatives involved in osteoclast activity, validation of the identified polynucleotides for their potential as therapeutic targets and use of the polynucleotides, polypeptides, variants and derivatives for the amelioration of disease states and research purposes..
Alethia Biotherapeutics Inc.
04/23/15
20150110765
new patent

Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having alpha-glucuronidase activity, catalytic domains and polynucleotides encoding the polypeptides, catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains..
Novoyzmes A/s
04/23/15
20150110757
new patent

Modification of cxcr4 using engineered zinc finger proteins


Disclosed herein are methods and compositions for modulating activity of cxcr4 genes, for example using zinc finger transcription factors (zf-tfs) or zinc finger nucleases (zfns) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding zf-tfs or zfns, vectors comprising polynucleotides encoding zf-tfs or zfns and cells comprising polynucleotides encoding zf-tfs or zfns and/or cells comprising zf-tf or zfns are also provided..
Sangamo Biosciences, Inc.
04/23/15
20150110732
new patent

Poly(vinyl ester) polymers for in vivo nucleic acid delivery


The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of rna interference (rnai) polynucleotides to cells in vivo. Rnai polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery.
Arrowhead Madison Inc.
04/16/15
20150106973

Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency


Provided are isolated polynucleotides comprising a nucleic acid sequence encoding a polypeptide at least 80% identical to seq id no: 422, 362-421, 423-601, 2429-4085 and 4086, such as a polynucleotide which is at least 80% identical to seq id no: 260, 1-259, 261-361, 602-2427 and 2428, nucleic acid constructs comprising same, plant cells comprising same, transgenic plants expressing same, and methods of generating thereof for increasing the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, nitrogen use efficiency and/or abiotic stress tolerance of a plant.. .
Evogene Ltd.
04/16/15
20150106971

Threonine synthase from nicotiana tabacum and methods and uses thereof


There is disclosed a mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a threonine synthase and having at least 90% sequence identity to seq id no:1, seq id no:2 or seq id no:3 or at least 87% sequence identity to seq id no:4, or seq id no:5; (ii) a polypeptide encoded by any one of said polynucleotides set forth in (i); or (iii) a polypeptide having at least 95% sequence identity to seq id no:6, seq id no:7 or seq id no:8; or (iv) a construct, vector or expression vector comprising the polynucleotide as set forth in (i).. .
Philip Morris Products S.a.
04/16/15
20150105544

Polynucleotide comprising sequences of wheat gliadins and use thereof for silencing by rnai


The present invention relates to the specific silencing of the α (alpha), β (beta), γ (gamma) and ω (omega)-gliadins of hard wheat for flour by rna interference (rnai) through employment of a polynucleotide which is transcribed into an hprna (hairpin rna). Furthermore the present invention additionally relates to a vector, cell, plant or seed comprising the polynucleotide, the expression whereof is specifically directed in particular tissues of wheat seeds through gene expression-regulating sequences such as, for example, the promoter of a gene of γ-gliadins or the promoter of the gene encoding for a d-hordein..
Consejo Superior De Investigaciones Cientificas
04/16/15
20150105451

Treatment of paraoxonase 1 (pon1) related diseases by inhibition of natural antisense transcript to pon1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of paraoxonase 1 (pon1), in particular, by targeting natural antisense polynucleotides of paraoxonase (pon1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of pon1..
Curna, Inc.
04/16/15
20150105321

Coagulation factor vii polypeptides


The present invention relates to modified coagulation factor vii polypeptides exhibiting increased resistance to antithrombin inactivation and enhanced proteolytic activity. The present invention also relates to polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing such polynucleotides, pharmaceutical compositions, uses and methods of treatment..
Novo Nordisk A/s
04/16/15
20150105299

Method for differentiation of polynucleotide strands


Objective of the present invention is to provide a method for keeping of directional information in double-stranded dna. We suggest to convert polynucleotide into a hybrid double-stranded dna.
Max-planck-gesellschaft Zur Forderung Der Wissenschaften E.v.
04/16/15
20150105297

Electrical polynucleotide mapping


A plurality of detector elements for detecting the labels by acquiring the detection signals, the detector elements being positioned longitudinally along the micro-fluidic channel, each detector element having a width, successive detector elements being separated by an inter-detector gap having a width, wherein the widths of at least two of the detector elements are different and/or wherein the widths at least two of the inter-detector gaps are different.. .
04/16/15
20150104874

Akt ligands and polynucleotides encoding akt ligands


The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate akt activity.
Intrexon Corporation
04/16/15
20150104837

Genes encoding biofilm formation inhibitory proteins and a producing l-lysine using a bacterial strain with the inactivated genes


The present invention relates to a novel isolated gene (polynucleotide) which encodes a protein having a biofilm formation inhibitory activity derived from coryneform bacteria, a l-lysine-producing strain in which the polynucleotide is inactivated, and a method for producing l-lysine using the same.. .
Cj Cheiljedang Corporation
04/16/15
20150104437

Methods for the treatment and diagnosis of bone mineral density related diseases


The present invention relates to methods of the treatment and diagnosis of bone mineral density related disorders. More particularly, the present invention relates to a method of diagnosing or predicting a hone mineral density related disease, or a risk of a bone mineral density related disease, in a subject, which method comprises detecting a mutation in the tbxas1 gene, wherein the presence of said mutation is indicative of a bone mineral density related disease or of a risk of a bone mineral density related disease.
Inserm (institut National De La Sante Et De La Recherche Medicale)
04/16/15
20150104408

Poly(acrylate) polymers for in vivo nucleic acid delivery


The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of rna interference (rnai) polynucleotides cells in vivo. Rnai polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery.
Arrowhead Madison Inc.
04/09/15
20150101079

Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics


Provided are isolated polynucleotides which comprise a nucleic acid sequence at least 80% identical to seq id no: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739; isolated polypeptides which comprise an amino acid sequence at least 80% homologous to seq id no: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737, and methods of using same for increasing a yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.. .
Evogene Ltd.
04/09/15
20150101078

Drought tolerant plants and related constructs and methods involving genes encoding dtp21 polypeptides


Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a dtp21 polypeptide..
Pioneer Hi-bred International Inc
04/09/15
20150099708

Wnt compositions and therapeutic uses of such compositions


The invention provides novel wnt polypeptides that have improved production characteristics, solubility, systemic delivery, and tissue uptake, and polynucleotides encoding the wnt polypeptides of the invention. The wnt polypeptides of the invention can be used therapeutically, such as, for example, in methods of preventing or treating muscle loss and/or promoting muscle hypertrophy and growth..
Fate Therapeutics, Inc.
04/09/15
20150099705

Protoxin -ii variants and methods of use


The present invention relates to protoxin-ii variants, polynucleotides encoding them, and methods of making and using the foregoing.. .
Janssen Biotech, Inc.
04/09/15
20150099281

Method for producing l-lysine using microorganisms having ability to produce l-lysine


The present invention relates to a modified polynucleotide encoding aspartate kinase (ec:2.7.2.4; hereinafter, referred to as lysc), transketolase (ec:2.2.1.1; hereinafter, referred to as tkt) or pyruvate carboxylase (ec:6.4.1.1; hereinafter, referred to as pyc), in which the initiation codon is substituted with atg, a vector including the same, a microorganism transformed with the vector, and a method for producing l-lysine using the same.. .
Cj Cheiljedang Corporation
04/09/15
20150099278

Polynucleotides encoding antibodies


The present invention relates to antagonizing the activity of il-17a, il-17f and il-23 using bispecific antibodies that comprise a binding entity that is cross-reactive for il-17a and il-17f and a binding entity that binds il-23p19. The present invention relates to novel bispecific antibody formats and methods of using the same..
Bristol-myers Squibb Company
04/09/15
20150098990

Peptides that target dorsal root ganglion neurons


The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (drg) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example.
Baylor College Of Medicine
04/02/15
20150096083

Genome wide identification and characterization of gene expression regulatory elements in zea mays for use in plants


The present invention provides non-coding regulatory element polynucleotide molecules isolated from the lipid transfer protein (ltp) gene of oryza sativa and useful for expressing transgenes in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the oryza sativa regulatory polynucleotide sequences, and methods for preparing and using the same..
Monsanto Technology Llc
04/02/15
20150094450

Repebody for novel interleukin-6 and use thereof


The present invention relates to an repebody capable of binding specifically to interleukin-6 (il-6) to inhibit the biological activity of il-6, a polynucleotide encoding the repebody, a vector comprising the polynucleotide, a recombinant microorganism having introduced therein the polynucleotide or the vector, a method of producing the repebody using the recombinant microorganism, a composition for preventing or treating cancer, which comprises the repebody, and a method for preventing or treating cancer, which comprises administering the composition for preventing or treating cancer, which comprises the repebody. The repebody of the present invention significantly reduces the activity of stat3 and the concentration of interleukin-6, and thus can be widely used as an agent for preventing or treating il-6-related diseases..
Korea Basic Science Institute
04/02/15
20150094358

Treatment of hepatocyte growth factor (hgf) related diseases by inhibition of natural antisense transcript to hgf


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of hepatocyte growth factor (hgf), in particular, by targeting natural antisense polynucleotides of hepatocyte growth factor (hgf). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of hgf..
Curna, Inc.
04/02/15
20150094356

Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of dystrophin family, in particular, by targeting natural antisense polynucleotides of dystrophin family. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of dmd family..
Curna, Inc.
04/02/15
20150094271

Leucine zipper variant and use thereof


A leucine zipper variant, a polynucleotide encoding the leucine zipper variant, a method of preparing a leucine zipper variant, a method of inhibiting hdm2- and/or hdmx using the leucine zipper variant, and a method of the prevention and/or treatment of cancer using the leucine zipper variant.. .
Samsung Electronics Co., Ltd.
04/02/15
20150094224

Methods for the diagnosis or prognosis of breast cancer


Methods for detecting, diagnosing and monitoring an epithelial cancer in a patient are described comprising measuring in a sample from the patient ep-icd polypeptides and ep-icd polynucleotides. Methods for prognosis of breast cancer comprising measurement of nuclear ep-icd polypeptides and optionally epex polypeptides are provided.
04/02/15
20150094222

Quantitative multiplex methylation specific pcr method- cmethdna, reagents, and its use


The cmethdna method of the present invention is a novel modification of the qm-msp method (u.s. Pat.
The Johns Hopkins University
04/02/15
20150093824

Methods and compositions for inhibiting the function of polynucleotide sequences


A therapeutic composition for inhibiting the function of a target polynucleotide sequence in a mammalian cell includes an agent that provides to a mammalian cell an at least partially double-stranded rna molecule comprising a polynucleotide sequence of at least about 200 nucleotides in length, said polynucleotide sequence being substantially homologous to a target polynucleotide sequence. This rna molecule desirably does not produce a functional protein.
Alnylam Pharmaceuticals, Inc.
04/02/15
20150093795

Cutinase variants and polynucleotides encoding same


The present invention relates tocutinasevariants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s
04/02/15
20150093792

Polypeptides having glucoamylase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes North America, Inc.
04/02/15
20150093358

Long-acting polypeptides and methods of producing and administering same


A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also discarded..
Opko Biologics Ltd.
03/26/15
20150089688

Compositions and methods of gene silencing in plants


Compositions and methods for inducing gene silencing events in plants are disclosed. The compositions typical include a polynucleotide encoding an mirna target sequence operably linked to a sequence of from a target gene, cdna or mrna, or fragment thereof.
The Board Of Trustees Of The University Of Illinois
03/26/15
20150089687

Novel antifungal proteins and methods of use


Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for novel variants of antipathogenic polypeptides generated through dna shuffling that exhibit improved antipathogenic activity.
Pioneer Hi Bred International Inc
03/26/15
20150087695

Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo


Oligonucleotide compounds modulate expression and/or function of erythropoietin (epo) polynucleotides and encoded products thereof. Methods for treating diseases associated with erythropoietin (epo) comprise administering one or more oligonucleotide compounds designed to inhibit the epo natural antisense transcript to patients..
Curna, Inc.
03/26/15
20150087604

Anti-fatty acid synthase polypeptide and use thereof


The present invention relates to a polypeptide that is capable of inhibiting transcription and expression of fatty acid synthase (fas) and the polynucleotides encoding therefor, as well as the use thereof. Specifically, the present invention relates to a polypeptide that can inhibit the transcription and expression of fas at the molecular level, the cellular level and in vivo, and can therefore prevent the overexpression of fas.
Tianjin Toptech Bio-science & Technology Co., Ltd.
03/26/15
20150087596

Huwentoxin-iv variants and methods of use


The present invention relates to huwentoxin-iv variants, polynucleotides encoding them, methods of making and using the foregoing, and methods of alleviating pain with peptide inhibitors of nav1.7.. .
Janssen Biotech, Inc.
03/26/15
20150087557

Enzyme composition for dna end repair, adenylation, phosphorylation


Enzyme compositions and their method of use that provide ready-to-use master mixtures. The compositions comprise a modified thermophilic dna polymerase lacking 5′-3′ and 3′-5′ exonuclease activity premixed with t4 dna polymerase, klenow fragment and t4 polynucleotide kinase and all other necessary components, including reaction buffer and nucleoside triphosphates, required to perform dna blunting, phosphorylation, and single nucleotide extension reactions in one tube and in two steps.
Thermo Fisher Scientific Baltics Uab
03/26/15
20150087537

Methods, systems, computer readable media, and kits for sample identification


A method for sequencing a polynucleotide sample having a barcode sequence includes: introducing a series of nucleotides to the polynucleotide sample according to a predetermined order of nucleotide flows; obtaining a series of signals resulting from the introducing of nucleotides to the polynucleotide sample; and resolving the series of signals over the barcode sequence to render a flowspace string, wherein the flowspace string is a codeword of an error-correcting code that is (i) designed based on and adapted for use with the predetermined order of nucleotide flows, and (ii) capable of distinguishing any codeword in the error-correcting code from the other codewords in the error-correcting code in the presence of zero, one, and two errors.. .
Life Technologies Corporation
03/26/15
20150087067

Methods and compositions for inactivating glutamine synthetase gene expression


Disclosed herein are methods and compositions for inactivating a glutamine synthetase (gs) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins..
Sangamo Biosciences, Inc.
03/26/15
20150087047

Process for production of recombinant proteins as a soluble form


A target protein is prepared as soluble protein using a recombinant protein expression system. An expression vector is used that includes (1) an expression-inducible promoter sequence; (2) a first coding sequence including a polynucleotide coding for a polypeptide that is represented by the formula (z)n; and (3) a second coding sequence that includes a polynucleotide that codes for a target protein.
Jnc Corporation
03/26/15
20150087029

Genes encoding cellulase for hydrolyzing guar fracturing fluids under extreme well conditions


polynucleotide sequences encoding a thermostable cellulase and directing its increased expression are provided, and hydraulic fracturing compositions comprising such thermostable cellulase.. .
Verenium Corporation
03/26/15
20150087027

Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase


The present invention is directed to methods and compositions for adding tails of specific lengths to a substrate polynucleotide. The invention also contemplates methods and compositions for immobilization of tailed substrates to a solid support.
Swift Biosciences, Inc.
03/26/15
20150086614

Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.
03/26/15
20150086613

Lipid-derived neutral nanoparticles


Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells.
Shire Human Genetic Therapies, Inc.
03/26/15
20150086568

Anti-vegf antibodies


The invention herein provides isolated antibodies that bind to vegf. The invention further provides methods of making anti-vegf antibodies, and polynucleotides encoding anti-vegf antibodies..
Genentech, Inc.
03/26/15
20150086556

Anti-activin a antibodies and uses thereof


The disclosure provides compositions and methods relating to or derived from anti-activin a binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin a antibodies that bind human activin a, activin a-binding fragments and derivatives of such antibodies, and activin a-binding polypeptides comprising such fragments.
Amgen Inc.
03/26/15
20150086525

Prebiotic composition or pharmaceutical composition synthesized from catalytic domains producing highly alpha-1,2 branched dextran


The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with .alpha.(1.fwdarw.2) sidechains, comprising at least one region for bonding to glucan and a catalytically active region situated beyond the region bonding to glucan. The invention further relates to polynucleotides coding for said enzymes and vectors containing the same..
Institut National Des Sciences Appliquees (insa)
03/19/15
20150082493

Gh61 polypeptide variants and polynucleotides encoding same


The present invention relates to gh61 polypeptide variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes, Inc.
03/19/15
20150082489

Polynucleotides and polypeptides for increasing desirable plant qualities


Polynucleotides and isolated polypeptides, nucleic acid constructs comprising the isolated polynucleotides, transgenic plants expressing same and methods of using same for increasing abiotic stress tolerance, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, and/or nitrogen use efficiency of a plant are disclosed.. .
Evogene Ltd.
03/19/15
20150082488

Isolated polynucleotides encoding a map65 polypeptide and methods of using same for increasing plant yield


Provided are methods of increasing yield, biomass, growth rate, vigor, and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence at least 80% identical to seq id no: 27 or 868; or an exogenous polynucleotide encoding a polypeptide at least 80% identical to seq id no: 132 (map65 from arabidopsis).. .
Evogene Ltd.
03/19/15
20150082487

Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance, biomass and/or yield in plants expressing same


Provided are isolated polynucleotides comprising a nucleic acid sequence at least 80% identical to seq id no:619, 617, 606, 615, 629, 1-36, 40, 41, 43-45, 49, 52-56, 58, 113-343, 351, 354-358, 605, 607-614, 616, 618, 620-628, 630-638, 642, 645, 650, 651, 670, or 671. Also provided are nucleic acid constructs comprising same, isolated polypeptides encoded thereby, transgenic cells and transgenic plants comprising same and methods of using same for increasing abiotic stress tolerance, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, and/or nitrogen use efficiency of a plant..
Evogene Ltd.
03/19/15
20150082486

Isolated polynucleotides and polypeptides, and methods of using same for increasing yield of plants


Provided are isolated polynucleotides and nucleic acid constructs which comprise a nucleic acid sequence at least 80% identical to a nucleic acid sequence selected form the group consisting of seq id nos: 1-219, 367-5628, 9688-9700, and 9709-9752; and isolated polypeptides which comprise an amino acid sequence at least 80% homologous to an amino acid sequence selected from the group consisting of seq id nos: 220-366, 5629-9400, 9701-9708, and 9753-9796. Also provided are transgenic cells and plants expressing same and methods of using same for increasing yield, growth rate, biomass, vigor, oil content, seed yield, fiber yield, fiber quality, nitrogen use efficiency, and/or abiotic stress of a plant..
Evogene Ltd.
03/19/15
20150082481

Nucleic acid molecules and other molecules associated with transcription in plants and uses thereof for plant improvement


Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
Monsanto Technology Llc
03/19/15
20150082478

Plant genome modification using guide rna/cas endonuclease systems and methods of use


Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide rna/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed.
Pioneer Hi-bred International Inc
03/19/15
20150080456

Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of nuclear respiratory factor 1 (nrf1), in particular, by targeting natural antisense polynucleotides of nuclear respiratory factor 1 (nrf1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of nrf1..
Curna, Inc.
03/19/15
20150080455

Treatment of transcription factor e3 (tfe3) and insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to tfe3


The present invention relate to antisense oligonucleotides that modulate the expression of and/or function of transcription factor e3 (tfe3) and/or insulin receptor substrate 2 (irs2) polynucleotides, in particular, by targeting natural antisense polynucleotides of transcription factor e3 (tfe3) and/or insulin receptor substrate 2 (irs2). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of tfe3 and/or irs2..
Curna, Inc.
03/19/15
20150080306

Therapeutic agents comprising elastic peptides


The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation.
Duke University
03/19/15
20150080241

Polynucleotide and use thereof


A polynucleotide comprising a first region the 5′ end of which is complementary to a portion of a target nucleic acid, a cleavable second region, a third region having a stem-loop structure, and a fourth region complementary to the 3′ end of the first region, and use of the polynucleotide, as well as a composition comprising two such polynucleotides each of which hybridize different strands of a double-stranded target nucleic acid, and methods and kits using the same for amplifying targets.. .
Samsung Electronics Co., Ltd.
03/19/15
20150079106

Anti-neoplastic uses of artemin antagonists


The invention relates to methods for the prophylaxis and treatment of breast cancer using one or more antagonists of artemin function, such as anti-artemin polynucleotides or anti-artemin antibodies and antibody fragments, and uses of these antagonists. In particular, the invention relates to the resensitisation of therapy-resistance breast cancer cells to anti-cancer therapies by antagonism of artemin functionality..
Auckland Uniservices Limited
03/19/15
20150079065

Klotho variant polypeptides and uses thereof in therapy


Disclosed are klotho variant proteins in which residue glu414 and/or residue asp238 is substituted with an amino acid different than l-glu or l-asp, respectively, as well as polynucleotides encoding the variant proteins, and the use thereof in therapy, especially for the treatment of cancers, especially breast cancer and pancreatic cancer.. .
Tel Hashomer Medical Research Infrastructure And Services Ltd.
03/19/15
20150079063

Long-acting coagulation factors and methods of producing same


Polypeptides comprising at least one carboxy-terminal peptide (ctp) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed..
Opko Biologics Ltd.


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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