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This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
02/26/15
20150059018
 Methods and compositions for producing drimenol patent thumbnailMethods and compositions for producing drimenol
The present invention relates to nucleic acids sequences derived from valeriana officinalis and/or persicaria hydropiper and encoding drimenol synthase polypeptides. The present invention also provides the amino acid sequences of the polypeptides.
Keygene N.v.
02/26/15
20150059014
 Polynucleotides and polypeptides in plants patent thumbnailPolynucleotides and polypeptides in plants
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
Mendel Biotechnology, Inc.
02/26/15
20150059010
 Genome modification using guide polynucleotide/cas endonuclease systems and methods of use patent thumbnailGenome modification using guide polynucleotide/cas endonuclease systems and methods of use
Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a cell or organism.
Pioneer Hi-bred International Inc
02/26/15
20150057338
 Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene patent thumbnailTreatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a pancreatic developmental gene, in particular, by targeting natural antisense polynucleotides of a pancreatic developmental gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of pancreatic developmental genes..
Curna, Inc.
02/26/15
20150057335
 Novel fusion genes identified in lung cancer patent thumbnailNovel fusion genes identified in lung cancer
[means for solving] a method for detecting a gene fusion serving as a responsible mutation (driver mutation) for cancer, the method comprising the step of detecting any one of an ezr-erbb4 fusion polynucleotide, a kiaa1468-ret fusion polynucleotide, a trim24-a braf fusion polynucleotide, a cd74-nrg1 fusion polynucleotide, and an slc3a2-nrg1 fusion polynucleotide, or a polypeptide encoded thereby, in an isolated sample from a subject with cancer.. .
02/26/15
20150057182
 Methods for analysis of dna fragments patent thumbnailMethods for analysis of dna fragments
A method of genotyping includes applying a sample solution including a plurality of copies of a sample polynucleotide to an array of sensors. The sample polynucleotide includes a region associated with an allele.
Life Technologies Corporation
02/26/15
20150057179
 Methods and compositions for hte diagnosis and treatment of thyroid cancer patent thumbnailMethods and compositions for hte diagnosis and treatment of thyroid cancer
Methods for detecting thyroid cancer or thyroid cancer status in a subject are described comprising measuring novel markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for thyroid cancer, and kits for carrying out the methods of the invention.
02/26/15
20150057169
 Biomarkers for head-and-neck cancers and precancers patent thumbnailBiomarkers for head-and-neck cancers and precancers
The invention provides markers and methods for detecting head-and-neck precancers, (including opls), cancers and related disease conditions in a subject. The invention also provides localization and imaging methods for head-and-neck precancers (including opls) and cancers, along with kits for carrying out methods of the invention.
02/26/15
20150056680
 Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses patent thumbnailMethods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor.
Ibc Pharmaceuticals, Inc.
02/26/15
20150056670
 Microorganism producing 4-hydroxybutyrate and a  producing 4-hydroxybutyrate in anaerobic condition using the same patent thumbnailMicroorganism producing 4-hydroxybutyrate and a producing 4-hydroxybutyrate in anaerobic condition using the same
A genetically modified microorganism comprising a polynucleotide encoding α-ketoglutarate synthase or a mutant thereof, and a polynucleotide encoding pyruvate carboxylase or a mutant thereof; wherein the genetically modified microorganism has decreased malate quinone oxidoreductase activity and/or decreased phosphoenolpyruvate carboxykinase activity compared to an unmodified microorganism of the same type, and wherein the genetically modified microorganism produces 4-hydroxybutyrate.. .
Samsung Electronics Co., Ltd.
02/26/15
20150056668

Synthesis of prazole compounds


The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. .
Codexis, Inc.
02/26/15
20150056666

Variants of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase


The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.. .
Evonik Degussa Gmbh
02/26/15
20150056243

Multicomponent or monocomponent vaccine to be used against chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure


A vaccine against the chagas disease, capable of stimulating the immune response against the trans-sialidase virulence factor of the trypanosoma cruzi parasite, which is a multicomponent vaccine comprising: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions codifying one or more immunogenic polypeptides, or a monocomponent vaccine comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions codifying one or more immunogenic polypeptides derived from trypanosoma cruzi and pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.. .
02/26/15
20150056236

An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof


The invention provides isolated polynucleotide molecules that comprise a dna sequence encoding an infectious rna sequence encoding a genetically-modified north american prrs virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of north american prrs virus. The invention also provides vaccines comprising genetically modified north american prrs virus, rna molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules.
Zoetis Llc
02/26/15
20150056193

Egfr and ros1 kinase in cancer


The present disclosure provides methods of that include detecting in a biological sample from a patient having or suspected of having cancer the presence of a polypeptide having ros1 kinase activity or a polynucleotide encoding the same and detecting in the biological sample the presence of a mutant egfr polypeptide or a polynucleotide encoding the same. In some aspects, the disclosure provides methods of treating a patient for cancer that include determining that a biological sample from a tumor in the patient includes a polypeptide having ros1 kinase activity or a polynucleotide encoding the same and a mutant egfr polypeptide or a polynucleotide encoding the same and administering to the patient a therapeutically effective amount of a ros1 inhibitor and an egfr inhibitor, thereby treating the patient for cancer..
Cell Signaling Technology, Inc.
02/26/15
20150056178

Modified beta-lactamases and methods and uses related thereto


Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.. .
02/26/15
20150056134

Nucleic acids encoding human antibodies to sialyl-lewis a


The present invention provides compositions for the production of an antibody or functional fragment thereof directed against sialyl-lewisa (slea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to slea.
Mabvax Therapeutics, Inc.
02/19/15
20150052643

Compositions and methods for insecticidal control of stinkbugs


Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pentatomidae plant pest or a n. Viridula, acrosternum hilare, piezodorus guildini, and/or halymorpha halys plant pest, decrease the expression of a target sequence in the pest.
E I Du Pont De Nemours And Company
02/19/15
20150052633

Mutation of the ear motif of class ii hd-zip polypeptides


The application describes producing polynucleotide variants of the athb 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the ear motifs..
Mendel Biotechnology, Inc.
02/19/15
20150050715

Stably tethered structures of defined compositions with multiple functions or binding specificities


The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor.
Ibc Pharmaceuticals, Inc.
02/19/15
20150050704

Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs


The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (nrps) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the nrps derived drug..
Colorado State University Research Foundation
02/19/15
20150050702

Recombinant c1 beta-glucosidase for production of sugars from cellulosic biomass


The invention relates to expression of a recombinant c1 β-glucosidase. The invention also provides methods for producing a fermentable sugar from cellobiose by contacting cellobiose with a recombinant host cell comprising a polynucleotide sequence encoding c1 β-glucosidase, operably linked to heterologous promoter, under conditions in which β-glucosidase is expressed and secreted by the cell and the cellobiose is enzymatically converted by said β-glucosidase to glucose.
Codexis, Inc.
02/19/15
20150050354

Modified polynucleotides for the treatment of otic diseases and conditions


The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides in the treatment, prevention and/or amelioration of otic diseases or conditions.. .
Moderna Therapeutics, Inc.
02/19/15
20150050296

Methods and compositions for inhibition of innate immune responses and autoimmunity


The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.. .
Dynavax Technologies Corporation
02/19/15
20150050286

Anti-ngf antibodies and methods using same


The invention concerns anti-ngf antibodies (such as anti-ngf antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain..
Rinat Neuroscience Corp.
02/19/15
20150050279

B-cell receptor complex binding proteins containing t-cell epitopes


The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of cd22, cd19, cd20, and cd21, and b) an immunogenic peptide comprising at least one t-cell epitope for use in vaccination of a subject against b-cell hyperproliferation or for use in the modulation of the immune response in a subject. The present invention further relates to a polynucleotide and a vector encoding said polypeptide and a host cell comprising the same.
Deutsches Krebsforschungszentrum
02/19/15
20150050250

Cell therapy technology to deliver radio-protective peptides


A method of reducing a symptom of radiation exposure in a subject is provided. The method includes a step of introducing mammalian cells into the subject, the mammalian cells having been treated ex vivo to insert therein a polynucleotide encoding polypeptide that is protective against radiation.
University Of Southern California
02/19/15
20150050243

Delivery of packaged rna to mammalian cells


Described herein are compositions relating to alphavirus-based virus-like particles (vlps) and methods for making and using the described vlps. The described compositions include vlps and vectors and cells used to produce the vlps.
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
02/12/15
20150047076

Pesticidal toxin active against coleopteran and/or hemipteran insects


The present invention provides novel insecticidal proteins active against a coleopteran and/or hemipteran species pest, which include, but are not limited to, tic3131, tic3400 and tic3407 proteins. The present invention also provides a dna construct comprising operably linked to a heterologous promoter a polynucleotide that encodes the novel insecticidal protein or an insecticidal fragment thereof.
Monsanto Technology Llc
02/12/15
20150047075

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.
02/12/15
20150047060

Transgenic animal model of mood disorders


A non-human transgenic animal having a polynucleotide encoding a ptn polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the ptn polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illnesses, particularly anxiety and depression, are disclosed.. .
Brainco Biopharma, S.l.
02/12/15
20150045535

Bacillus licheniformis chromosome


The present invention relates to an isolated polynucleotide of the complete chromosome of bacillus licheniformis sj1904 (atcc pta-7992). The present invention also relates to isolated polynucleotides of the chromosome of bacillus licheniformis sj1904 that encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing biologically active substances encoded by the polynucleotides and to methods of using the isolated polynucleotides of the complete chromosome of bacillus licheniformis sj1904..
Novozymes, Inc.
02/12/15
20150045414

Trans-acting rna switches


Disclosed are rna constructs which function to activate or inactivate a biological process, e.g., may be designed for attachment to a polypeptide coding region. Such rna constructs modulate translation of a polypeptide from the coding region in response to the presence of a target polynucleotide in an expression environment.
The Research Foundation Of The University Of New York
02/12/15
20150045255

Endometrial phase or endometrial cancer biomarkers


Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention.
02/12/15
20150045243

Mirnas as non-invasive biomarkers for diagnosis


The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of a disease in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of mirnas for diagnosing and/or prognosing of a disease in a body fluid sample from a subject..
02/12/15
20150045219

Abiotic and biotic stress tolerance peptides and polynucleotides, and compositions and methods comprising them


X is an amino acid chosen from alanine (a), cysteine (c), aspartic acid (d), glutamic acid (e), phenylalanine (f), glycine (g), histidine (h), isoleucine (i), lysine (k), leucine (l), methionine (m), asparagine (n), proline (p), glutamine (q), arginine (r), serine (s), threonine (t), valine (v), tryptophan (w), or tyrosine (y); (c) growing the plant to produce developed seeds from the plant comprising defenses induced by the defense activators.. .
02/12/15
20150044771

Novel frt recombination sites and methods of use


Methods and compositions using populations of randomized modified frt recombination sites to identify, isolate and/or characterize modified frt recombination sites are provided. The recombinogenic modified frt recombination sites can be employed in a variety of methods for targeted recombination of polynucleotides of interest, including methods to recombine polynucleotides, assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excise a polynucleotide, and identify and/or characterize transcriptional regulating regions are also provided..
Pioneer Hi-bred International, Inc.
02/12/15
20150044756

Methods of increasing secretion of polypeptides having biological activity


The present invention relates to methods for producing a secreted polypeptide having biological activity, comprising: (a) transforming a fungal host cell with a fusion protein construct encoding a fusion protein, which comprises: (i) a first polynucleotide encoding a signal peptide; (ii) a second polynucleotide encoding at least a catalytic domain of an endoglucanase or a portion thereof; and (iii) a third polynucleotide encoding at least a catalytic domain of a polypeptide having biological activity; wherein the signal peptide and at least the catalytic domain of the endoglucanase increases secretion of the polypeptide having biological activity compared to the absence of at least the catalytic domain of the endoglucanase; (b) cultivating the transformed fungal host cell under conditions suitable for production of the fusion protein; and (c) recovering the fusion protein, a component thereof, or a combination thereof, having biological activity, from the cultivation medium.. .
Novozymes, Inc.
02/12/15
20150044754

Polypeptides having alpha-amylase activity and polynucleotides encoding same


Provided are isolated polypeptides having alpha-amylase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains..
Novozymes A/s
02/12/15
20150044753

Expression vector comprising a polynucleotide encoding a modified glutamine synthetase and a preparing a target protein employing the same


The present invention relates to a vector comprising a polynucleotide encoding a modified glutamine synthetase (gs), and a method for preparing a target protein employing the same. More particularly, the present invention relates to a modified gs having an increased sensitivity to a glutamine synthetase (gs) inhibitor, a polynucleotide encoding the modified gs, a vector comprising the polynucleotide, a transformant comprising the vector, and a method for preparing a target protein using the transformant..
Hanwha Chemical Corporation
02/12/15
20150044736

Fungal cutinase from magnaporthe grisea


Described are compositions and methods relating to a fungal cutinase cloned from magnaporthe grisea, polynucleotides encoding the cutinase, and methods of use thereof. The compositions and methods have particular application in detergent cleaning compositions and synthesis reactions..
Danisco Us Inc.
02/12/15
20150044712

Method and kit for analyzing protein-protein interaction using nanocluster formation


For efficient analysis of a protein-protein interaction, the present disclosure provides a kit for analyzing a protein-protein interaction, the kit including: a 1st expression vector including a 1st polynucleotide and a multi-cloning site, wherein, the 1st polynucleotide is operably linked to a promoter and encodes a 1st fusion protein having a 1st fluorescence protein and a 1st self-assembly protein, and the multi-cloning site is a site where a polynucleotide encoding a bait protein may be operably linked to the polynucleotide encoding the 1st fusion protein; and a 2nd expression vector including a 2nd polynucleotide and a multi-cloning site, wherein, the 2nd polynucleotide is operably linked to a promoter and encodes a 2nd fusion protein having a 2nd fluorescence protein and a 2nd self-assembly protein, and the multi-cloning site is a site where a polynucleotide encoding a prey protein may be operably linked to the polynucleotide encoding the 2nd fusion protein.. .
Korea Advanced Institute Of Science And Technology
02/12/15
20150044709

Means and methods for determining neurotoxin activity based on a modified luciferase


The present invention is concerned with test systems for determining the activity of neurotoxin polypeptides. Specifically, it relates to a polynucleotide encoding a single chain luciferase fusion polypeptide comprising: (i) a luxb subunit, (ii) a linker comprising a neurotoxin cleavage site, and (iii) a luxa subunit and a polypeptide encoded by the polynucleotide.
Merz Pharma Gmbh & Co Kgaa
02/12/15
20150044277

Modified polynucleotides encoding caspase 3


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.
02/12/15
20150044255

Infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof


The invention provides isolated polynucleotide molecules that comprise a dna sequence encoding an infectious rna sequence encoding a genetically-modified north american prrs virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of north american prrs virus. The invention also provides vaccines comprising genetically modified north american prrs virus, rna molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules.
Zoetis Llc
02/05/15
20150040271

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.
02/05/15
20150038691

Polynucleotide configuration for reliable electrical and optical sensing


A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide..
International Business Machines Corporation
02/05/15
20150038680

Spider silk dragline polynucleotides, polypeptides and methods of use thereof


The disclosure provides spider silk polypeptides and polynucleotides encoding the same. Methods of using such polypeptides and polynucleotides and designing novel biomaterials using repeat units of the polypeptides and polynucleotides..
The Regents Of The University Of California
02/05/15
20150038675

Peptide having affinity for silicon nitride (si3n4), and use thereof


The purpose of the present invention is to provide: a peptide having an affinity for silicon nitride; a polynucleotide encoding the peptide; an expression vector for expressing the peptide having an affinity for silicon nitride; an expression vector for expressing a peptide fusion protein that comprises the peptide having an affinity for silicon nitride and a target protein; a transformant obtained by introducing the expression vector into a host cell; a peptide fusion protein obtained from the transformant; a silicon nitride substrate to which a peptide having an affinity for silicon nitride has been bonded; a method for immobilizing a target protein to a silicon nitride substrate; a composition for immobilizing a target protein to a silicon nitride substrate, the composition comprising a peptide having an affinity for silicon nitride; and a linker for immobilizing a target protein to a silicon nitride substrate, the linker comprising a peptide having an affinity for silicon nitride. The invention involves a peptide having an affinity for silicon nitride, the peptide comprising (1-1) a peptide having the amino acid sequence of one of seq id nos: 1, 2 and 23 to 27, (1-2) a peptide that has an affinity for silicon nitride and comprises an amino acid sequence obtained by deleting, adding, and/or substituting one or more amino acids in one of the amino acid sequences indicated in (1-1), or a fragment of one of the peptides..
National University Corporation Kyoto Institute Of Technology
02/05/15
20150038553

Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of atonal homolog 1 (atoh1), in particular, by targeting natural antisense polynucleotides of atonal homolog 1 (atoh1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of atoh1..
Curna, Inc.
02/05/15
20150038413

Long-acting polypeptides and methods of producing and administering same


A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed..
Opko Biologics Ltd.
02/05/15
20150038368

Biomolecule immobilization on a surface via hydrophobic interactions


A method, apparatus, or system for generating a pattern of polynucleotides on a substrate. The method includes providing a substrate having a hydrophobic surface.
Applied Biosystems, Llc
02/05/15
20150037869

Transaminase biocatalysts


The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. .
Codexis, Inc.
02/05/15
20150037843

Polynucleotide configuration for reliable electrical and optical sensing


A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide..
International Business Machines Corporation
02/05/15
20150037807

Direct and continuous root alone or root/shoot production from transgenic events derived from green regenerative tissues and its applications


The present invention provides assays and methods for efficiently testing a polynucleotide of interest for a phenotype in a root. In some embodiments, the assays and methods include regenerating green tissue that is transgenic for at least one polynucleotide of interest into one or more transgenic plantlets that have at least one transgenic root.
Pioneer Hi Bred International Inc
02/05/15
20150037794

Marker for diagnosing forelimb-girdle muscular anomaly in mammal individual, and detection method using same


The present invention uses an isolated polynucleotide having a part or whole of gfra1 gene, mutant gfra1 protein, and mrna encoding the mutant gfra1 protein, each of which includes a loss-of-function mutation of gfra1, as markers for diagnosing an animal as affected by forelimb-girdle muscular anomaly or as a carrier of forelimb-girdle muscular anomaly. In addition, an isolated polynucleotide comprising one or more selected from the group consisting of mok2630, mok2637, snp b, and snp d can be used as markers for diagnosing whether a bovine animal is affected by forelimb-girdle muscular anomaly or whether a bovine animal is a carrier of forelimb-girdle muscular anomaly..
National University Corporation Okayama University
02/05/15
20150037787

Polynucleotide configuration for reliable electrical and optical sensing


A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide..
International Business Machines Corporation
02/05/15
20150037401

Sirna compositions and methods for inhibiting gene expression in tumor initiating cells of breast cancer


Disclosed are methods and compositions for sirna-mediated therapy of mammalian diseases. In particular, compositions and methods are disclosed for treatment of therapy-resistant human breast cancers.
02/05/15
20150037364

Adenoviruses and their use


Baboon adenovirus (baadv)-2/4 and baadv-3 are disclosed herein. Baadv-2/4 and baadv-3 polynucleotide, polypeptides and antibodies that specifically bind baadv-2/4 and/or baadv-3 are disclosed.
The Government Of The United States Of America
02/05/15
20150037327

Mirna based treatment monitoring in multiple sclerosis


The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (ms), of monitoring the course of multiple sclerosis (ms) in a patient, of determining the risk for a relapse of multiple sclerosis (ms) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one mirna in a test sample isolated from the patient.
Comprehensive Biomarker Center Gmbh
02/05/15
20150037298

Micrornas for the generation of astrocytes


A method of generating a population of cells useful for treating a nerve disease or disorder in a subject, the method comprising up-regulating a level of at least one exogenous mirna in mesenchymal stem cells (mscs) and/or down-regulating a level of at least one mirna using a polynucleotide agent that hybridizes to the mirna, thereby generating the population of cells useful for treating the nerve disease or disorder. Isolated populations of cells with an astrocytic phenotype generated thereby and uses thereof are also provided..
Henry Ford Health System
01/29/15
20150033411

Genetically modified plants having improved saccharification properties


The invention relates to methods for increasing saccharification potential in a plant, comprising overexpressing a polynucleotide encoding an acetyl xylan esterase polypeptide in at least one cell type in said plant. The invention further relates to methods for producing genetically modified plants overexpressing a polynucleotide encoding an acetyl xylan esterase polypeptide, as well as to genetically modified plants produced by such methods..
Swe Tree Technologies Ab
01/29/15
20150033407

Regulatory polynucleotides and uses thereof


The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants.
Monsanto Technology Llc
01/29/15
20150031756

Lentiviral vectors and uses thereof


The invention relates to compositions containing polynucleotide vectors capable of expressing a nucleic acid encoding a fusion polypeptide on the surface of a viral particle and/or a eukaryotic cell.. .
Dana-farber Cancer Institute
01/29/15
20150031750

Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of brain derived neurotrophic factor (bdnf), in particular, by targeting natural antisense polynucleotides of brain derived neurotrophic factor (bdnf). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of bdnf..
Curna, Inc.
01/29/15
20150031743

Cell transfecting formulations of small interfering rna, related compositions and methods of making and use


Compositions incorporating small interfering ribonucleic acid (sirna) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery sirna and other polynucleotides to cells. Also, methods of making and using the compositions..
Novartis Vaccines And Diagnostics, Inc.
01/29/15
20150031601

Antimicrobial peptide variants and polynucleotides encoding same


The present invention relates to variants of a parent antimicrobial peptide. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Addenium Biotech Aps
01/29/15
20150031565

Determination of the identities of single nucleotide polymorphisms, point mutations and characteristic nucleotides in dna


A method of genotyping single nucleotide polymorphisms (“snp”) and point mutations in nucleic acid based on chain extension by polymerase. This invention is based on the fact that the neighboring sequence immediately 3′ adjacent to the site is known, and the nucleoside immediately 5′ adjacent to any snp/point mutation site is also known.
01/29/15
20150031559

Increased confidence of allele calls with molecular counting


Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (dbr) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment).
Population Genetics Technologies Ltd
01/29/15
20150031551

Control nucleic acid sequences for use in sequencing-by-synthesis and methods for designing the same


A method for nucleic acid sequencing includes (a) disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, at least some of the template polynucleotide strands comprising a test or control sequence; (b) exposing a plurality of the template polynucleotide strands in the defined spaces to a series of flows of nucleotide species flowed according to a predetermined ordering; and (c) determining sequence information for a plurality of the template polynucleotide strands in the defined spaces based on the flows of nucleotide species to generate a plurality of sequencing reads corresponding to the template polynucleotide strands, wherein the test or control sequence comprises a sequence determined by identifying, using a variant caller, loci with systematic errors present in a plurality of sequencing runs included in a training set of sequencing runs.. .
Life Technologies Corporation
01/29/15
20150031116

Integrated active flux microfluidic devices and methods


The invention relates to a microfabricated device for the rapid detection of dna, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g.
California Institute Of Technology
01/29/15
20150031113

Polypeptides having endoglucanase activity and polynucleotides encoding same


Provided are isolated polypeptides having endoglucanase activity, catalytic domains, cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides catalytic domains or cellulose binding domains..
Novozymes A/s
01/29/15
20150031111

Lipase variants and polynucleotides encoding same


The present invention relates to isolated lipase variants, comprising a substitution at one or more positions corresponding to positions i86d,e,n,q, e87c, i90d,e,q, and n92d,e,q of the mature polypeptide of seq id no: 2, wherein the variant has lipase activity. In some embodiments the present invention relates to isolated polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; methods of producing the variants; and compositions comprising the variants.
Novozymes A/s
01/29/15
20150031095

Enone reductases


The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations..
Codexis, Inc.
01/29/15
20150031094

Polynucleotides encoding engineered ketoreductase polypeptides


The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Codexis, Inc.
01/29/15
20150031091

Polypeptides having alpha-amylase activity and polynucleotides encoding same


The present invention provides isolated polypeptides having alpha-amylase activity catalytic domains, carbohydrate binding domains and polynucleotide encoding the polypeptides, catalytic domains or carbohydrate binding domains. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains..
Novozymes A/s
01/29/15
20150031082

Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s
01/29/15
20150031080

Cellobiohydrolase variants and polynucleotides encoding same


The present invention relates to variants of a parent cellobiohydrolase ii. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes, Inc.
01/29/15
20150031079

Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.
01/29/15
20150031060

Fad-conjugated glucose dehydrogenase gene


Disclosed herein are a gene (polynucleotide) encoding an fad-conjugated glucose dehydrogenase which can be characterized by reactivity to glucose, thermal stability, substrate-recognition performance, and low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; a method for the determination of glucose; a reagent composition for use in the determination of glucose; and a biosensor for use in the determination of glucose. An embodiment is a polynucleotide encoding an fad-conjugated glucose dehydrogenase, comprising a polypeptide whose amino acid sequence comprises x1-x2-x3-x4-x5-x6, wherein x1 and x2 independently represent an aliphatic amino acid residue; x3 and x6 independently represent a branched amino acid residue; and x4 and x5 independently represent a heterocyclic amino acid residue or an aromatic amino acid residue..
Ikeda Food Research Co., Ltd.
01/29/15
20150031034

Methods and compositions for detecting genetic material


This invention provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some cases, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma).
Bio-rad Laboratories, Inc.
01/29/15
20150031024

Enzymatic preparation of 10 base to 50 kb double-strand dna reagent for sequencing with a nanopore-polymerase sequencing device


The invention herein disclosed provides for devices, reagents, and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. Of particular note is the use of reagents to rapidly sequence a polynucleotide.
The Regents Of The University Of California


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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