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This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Isolated polynucleotides and polypeptides, transgenic plants comprising same and uses thereof in improving abiotic…

Methods, systems, and computer readable media for improving base calling accuracy

Date/App# patent app List of recent Polynucleotide-related patents
10/23/14
20140317786
 Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same patent thumbnailPolypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
10/23/14
20140317783
 Polynucleotides, polypeptides and methods for enhancing photossimilation in plants patent thumbnailPolynucleotides, polypeptides and methods for enhancing photossimilation in plants
The present invention relates generally to the field of molecular biology and regards various polynucleotides, polypeptides and methods that may be employed to enhance yield in transgenic plants. Specifically the transgenic plants may exhibit increased yield, increased biomass or increased photoassimilation..
10/23/14
20140317781
 Isolated polynucleotides and polypeptides, transgenic plants comprising same and uses thereof in improving abiotic stress tolerance, nitrogen use efficiency, biomass, vigor or yield of plants patent thumbnailIsolated polynucleotides and polypeptides, transgenic plants comprising same and uses thereof in improving abiotic stress tolerance, nitrogen use efficiency, biomass, vigor or yield of plants
Methods of improving abiotic stress tolerance, nitrogen use efficiency, biomass, vigor or yield of a plant are provided. According to an aspect the method comprising expressing within the plant an exogenous polynucleotide having a nucleic acid sequence at least 90% identical to seq id nos: 103, 101-102, 104-216, 223-227, 264-416, wherein the nucleic acid sequence is capable of regulating abiotic stress tolerance of the plant, thereby improving abiotic stress tolerance, nitrogen use efficiency, biomass, vigor or yield of the plant.
10/23/14
20140316716
 Methods, systems, and computer readable media for improving base calling accuracy patent thumbnailMethods, systems, and computer readable media for improving base calling accuracy
A method includes exposing template polynucleotide strands, sequencing primers, and polymerase to flows of nucleotide species; obtaining a series of measured intensity values and randomly selecting a training subset therefrom; generating series of base calls using a base caller and aligning the series of base calls to a reference genome or sequence using an aligner; determining intensity value thresholds and parameters of a linear transformation corresponding to different homopolymer lengths and nucleotide species; generating series of base calls corresponding to the series of measured intensity values using at least some of the parameters of a linear transformation; and recalibrating the series of base calls corresponding to the plurality of series of measured intensity values using at least some of the intensity value thresholds.. .
10/23/14
20140315987
 Cholecystokinin b receptor (cckbr) mini-promoters patent thumbnailCholecystokinin b receptor (cckbr) mini-promoters
Isolated polynucleotides comprising a cckbr mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
10/23/14
20140315822
 High mast2-affinity polypeptides and uses thereof patent thumbnailHigh mast2-affinity polypeptides and uses thereof
The invention relates to polypeptides containing a cytoplasmic domain ending with a mast-2 binding domain, from 11 to 13 residues, the first two residues of which are s and w, and the last four residues of which are q, t, r and l, said polypeptides presenting a high affinity for the pdz domain of the human mast2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same.
10/23/14
20140315730
 Scalable characterization of nucleic acids by parallel sequencing patent thumbnailScalable characterization of nucleic acids by parallel sequencing
A method for detecting the presence or absence of a target polynucleotide in a sample is described.. .
10/23/14
20140315314
 Engineered listeria and methods of use thereof patent thumbnailEngineered listeria and methods of use thereof
The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes..
10/23/14
20140315274
 Methods for production of archeae protease in yeast patent thumbnailMethods for production of archeae protease in yeast
The invention relates to: a method for producing a protease in yeast, comprising providing a yeast host cell comprising at least one polynucleotide expression construct encoding a first polypeptide secreted by the host cell in translational fusion with a second polypeptide, wherein the second polypeptide is a protease having a mature amino acid sequence similar to that of seq id no:2; the corresponding yeast host cell and the expression construct.. .
10/23/14
20140315201
 Method for high-throughput screening of transgenic plants patent thumbnailMethod for high-throughput screening of transgenic plants
The invention relates to a method for quantifying levels of expression and/or quantifying copy number of a heterologous polynucleotide in a transgenic plant using quantitative or real-time polymerase chain reaction (qpcr or real-time pcr), wherein the real-time pcr is performed using a primer set specific to a heterologous terminator sequence operably linked to the heterologous polynucleotide.. .
10/23/14
20140315197
Multifunctional probe-primers
Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple aliquots, and (3) a decoding and detection step in which the presence, absence, quantity, or relative amount of the target sequence in the aliquots is determined.
10/23/14
20140314858
Ipnv-isav bivalent vaccine using a virus-like particle-based platform and methods of using the same
The present invention provides bivalent oral vaccines against infectious pancreatic necrosis virus (ipnv) and infectious salmon anemia virus (isav). Yeast cells comprise an expression vector comprising (i) a polynucleotide sequence encoding a vp2 capsid protein of ipnv and (ii) a polynucleotide sequence encoding one or more antigenic epitopes of hemaglutinin of isav.
10/23/14
20140314843
Engineered phenylalanine ammonia lyase polypeptides
The present invention provides engineered phenylalanine ammonia-lyase (pal) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (pal) polypeptides.. .
10/23/14
20140314802
Novel compositions and methods
The present invention is directed to a polypeptide which comprises: (i) an rv2386c protein sequence; (ii) a variant of an rv2386c protein sequence; of (iii) an immunogenic fragment of an rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis..
10/16/14
20140310832
Stress tolerant wheat plants
The present invention relates to stress tolerant transgenic wheat plants. In particular, the present invention relates to stress tolerant transgenic wheat plants comprising an exogenous polynucleotide encoding a nac transcription factor operably linked to a promoter capable of directing expression of the polynucleotide in a cell of the plant..
10/16/14
20140309289
Combination anti-hiv vectors, targeting vectors, and methods of use
Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a ccr5 rnai; and an expression control element that regulates expression of the nucleic acid encoding the ccr5 rnai element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding trim5 alpha and hiv tar decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides.
10/16/14
20140309276
Pharmaceutical composition comprising a mixture of carboxylated oligonucleotides
The invention describes a pharmaceutical composition, comprising a mixture of carboxylated oligonucleotides, obtained by hydrolysis of natural polynucleotides, that results in oligonucleotide mixture, and carboxylation of purine nucleotide bases in the oligonucleotide mixture. The oligonucleotide mixture (dna, rna, or a combination of the two) of plant, animal, or fungal origin is conducted through chemical or biochemical enzymatic procedures, and then, a chemical modification of the oligonucleotides is provided, with carboxylation of their purine nucleotide bases through alkylation with monochloroacetic acid, or acylation with succinic anhydride.
10/16/14
20140309163
Fibronectin based scaffold domain proteins that bind to myostatin
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic kidney disease, heart failure, myocardial infarction, and fibrosis.
10/16/14
20140309145
High throughput method for assembly and cloning polynucleotides comprising highly similar polynucleotidic modules
The present invention relates to a method for the assembly and cloning of polynucleotides comprising highly similar polynucleotidic modules, that is highly versatile, does not require intermediate amplification step and can be easily automated for high throughput production of customized polynucleotidic modules.. .
10/16/14
20140309143
Centroid markers for image analysis of high density clusters in complex polynucleotide sequencing
Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is produced by generating on a solid support an immobilized nucleic acid complement from a template, one of which comprises a detectable label; and amplifying the complement and the template to obtain a nucleic acid cluster on the support, the cluster having a substantially central location marked by the detectable label and a surrounding region comprising immobilized copies.
10/16/14
20140309119
Methods and devices for high fidelity polynucleotide synthesis
Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products..
10/16/14
20140308732
Ketoreductase-mediated stereoselective route to alpha chloroalcohols
The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
10/16/14
20140308725
Polypeptides having glucoamylase activity and polynucleotides encoding same
The present invention provides isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. The invention also provides nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains..
10/16/14
20140308714
Decreased polysaccharide o-acetylation
The disclosure relates to polypeptides and polynucleotides from multiple species related to the o-acetylation of polysaccharides in plants. The disclosure also describes plants with reduced polysaccharide o-acetylation, methods related to the generation of plants with reduced polysaccharide o-acetylation, polysaccharides with reduced o-acetylation, and methods of using plants and polysaccharides having reduced o-acetylation..
10/16/14
20140308709
Polynucleotide and use thereof
Provided is a polynucleotide including, from the 3′ terminus of the polynucleotide to the 5′ terminus of the polynucleotide, a first region including a nucleotide sequence complementary to a nucleotide sequence of a portion of a target nucleic acid; a second region including a nucleotide sequence identical to a nucleotide sequence of a portion of the target nucleic acid; and a third region including a nucleotide sequence that self-hybridizes to form a stem-loop structure, and compositions, kits, and methods related thereto.. .
10/16/14
20140308706
Recombinant fusion interferon for animals
A recombinant fusion interferon for animals. The recombinant fusion interferon comprises an animal interferon and a fc region of an animal immunoglobulin g (igg).
10/16/14
20140308705
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
10/16/14
20140308700
Hydrogenase polypeptide and methods of use
Provided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles h2 produced min−1 mg protein−1.
10/16/14
20140308267
Neurotoxins exhibiting shortened biological activity
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein said polypeptide comprises at least one e3 ligase recognition motif in the light chain, wherein said e3 ligase recognition motif is preferably a binding motif for the e3 ligase mdm2.
10/16/14
20140308266
Modified neurotoxins with poly-glycine and uses thereof
The present invention is concerned with modified neurotoxins. Specifically, it relates to a modified biologically active neurotoxin polypeptide comprising at least one poly-glycine domain.
10/16/14
20140308211
Mutant protease biosensors with enhanced detection characteristics
A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the c-terminal portion of the thermostable luciferase to the n-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase.
10/09/14
20140304859
Polypeptides having endoglucanase activity and polynucleotides encoding same
Provided are isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
10/09/14
20140303093
Micro-utrophin polypeptides and methods
Described herein are polypeptides, polynucleotides and methods involving a μ-utrophin region or an anti-dystrophinopathic fragment thereof operationally linked to a second region effective to transduce the fusion protein into mammalian muscle cells.. .
10/09/14
20140303036
Nucleic acid assembly system
The present invention relates to a method for the preparation of a library of host cells, a plurality of which comprise an assembled polynucleotide at a target locus, which method comprises: (a) providing a plurality of polynucleotides comprising two or more polynucleotide subgroups, wherein: (i) a plurality of polynucleotides in each polynucleotide subgroup comprises sequence encoding a peptide or polypeptide and/or a regulatory sequence; (ii) a plurality of peptides or polypeptides encoded by, or a plurality of regulatory sequences comprised within, each polynucleotide subgroup share an activity and/or function; (iii) at least one polynucleotide subgroup comprises at least two non-identical polynucleotide species; (iv) a plurality of polynucleotides of each polynucleotide subgroup comprises sequence enabling homologous recombination with a plurality of polynucleotides from one or more other polynucleotide subgroups; and (v) a plurality of polynucleotides in two polynucleotide subgroups comprise a nucleotide sequence enabling homologous recombination with a target locus in host cells; and (b) assembling the plurality of polynucleotides at the target locus by homologous recombination in vivo in host cells, thereby to generate a library of host cells, a plurality of which comprise an assembled polynucleotide at the target locus. The assembled polynucleotides may be recovered, thereby to prepare a library of nucleic acids..
10/09/14
20140303032
Systems and methods for determining genetic data
Systems and methods of polynucleotide sequencing are provided. Systems and methods optimize control, speed, movement, and/or translocation of a sample (e.g., a polynucleotide) within, through, or at least partially through a nanopore or a type of protein or mutant protein in order to accumulate sufficient time and current blocking information to identify contiguous nucleotides or plurality of nucleotides in a single-stranded area of a polynucleotide..
10/09/14
20140303008
Colorectal cancer associated circulating nucleic acid biomarkers
The invention provides methods and reagents for diagnosing colorectal cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated. In some embodiments, the cna biomarkers are polynucleotide fragments, e.g., dna fragments, that are present at an elevated level in blood, e.g., in a serum or plasma sample, of a colorectal cancer patient in comparison to the level in blood, e.g., a serum or plasma sample, obtained from a normal individual who does not have colorectal cancer..
10/09/14
20140302607
Polymer based polynucleotide transfection agents
The present invention provides a methodology for transfecting cells in vitro. In particular, cationic polymers and polynucleotide containing polyplexes comprising such polymers are provided..
10/09/14
20140302588
Variant cbh2 cellulases and related polynucleotides
The invention provides variants of a streptomyces sp. Cbh2 that have improved properties compared to the wild type enzyme and methods of using the variants in the hydrolysis of substrates comprising cellulose..
10/09/14
20140302586
Variants of a family 44 xyloglucanase
The present invention relates to variants of a parent xyloglucanase. The present invention also relates to polynucleotides encoding the variant xyloglucanases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide..
10/09/14
20140302517
Anti-idiotype antibody against anti-c-met antibody
Disclosed are an anti-idiotype antibody that specifically binds to an idiotope site of an anti-c-met antibody, the use of the anti-idiotype antibody for detecting the anti-c-met antibody, and methods, polypeptides, polynucleotides, compositions, and vaccines related thereto.. .
10/09/14
20140302498
Rapid detection of the "high virulent" st-17 clone of group b streptococcus
The present invention also relates to kits and methods for the specific detection of group b streptococcus highly-virulent st-17 clones, using the polynucleotides, the polypeptides or the antibodies according to the invention.. .
10/09/14
20140302172
Markers for susceptibility to an inhibitor of an src-family kinase
The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the src family, whereby the individual is suspected to suffer from cancer.
10/09/14
20140302033
Albumin binding antibodies and binding fragments thereof
A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in seq id no: 1 or seq id no:2 and/or comprising a light chain variable domain having the sequence given in seq id no:3 or seq id no:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in seq id no: 1 and seq id no:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in seq id no: 2 and seq id no:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides.
10/09/14
20140300339
Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide
The present invention provides technology that uses current measurements to identify nucleotides and determine a nucleotide sequence in polynucleotides. The present invention calculates a modal value of a tunnel current that arises when a nucleotide or polynucleotide for analysis passes through between electrodes, and then employs the calculated modal value.
10/02/14
20140298547
Dna detection methods for site specific nuclease activity
The present disclosure provides methods for detecting and identifying plant events that contain precision targeted genomic loci, and plants and plant cells comprising such targeted genomic loci. The method can be deployed as a high throughput process utilized for screening the intactness or disruption of a targeted genomic loci and optionally for detecting a donor dna polynucleotide insertion at the targeted genomic loci.
10/02/14
20140298542
Nucleic acid agents for overexpressing or downregulating rna interference targets and uses of same in improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant
A method of improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant is provided by expressing within the plant an exogenous polynucleotide encoding a polypeptide having an amino acid sequence at least 80% homologous to seq id nos: 687-981, 992-1248, 1281-1310, 1389-1391, and 2806-3081. Also provided is a method of improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plan by expressing within the plant an exogenous polynucleotide which downregulates an activity or expression of a polypeptide having an amino acid sequence at least 80% homologous to seq id nos: 311-514, 2007-2436, 1311-1320, 982-991, 1249-1280, 1321-1388.
10/02/14
20140298541
Isolated polynucleotides expressing or modulating dsrnas, transgenic plants comprising same and uses thereof in improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant
A method of improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant is provided by expressing within the plant an exogenous polynucleotide at least 90% identical to seq id nos: 1-56, 62, 63, 110, 116, 117, 119-161, 200, 201-255, 1027-1031, 1459-1836. Also provided is a method of improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant by expressing within the plant an exogenous polynucleotide which downregulates an activity or expression of a gene encoding an rnai molecule having a nucleic acid sequence selected from the group consisting of seq id nos: 57-61, 64-115, 118, 162-200, 260-262, 265-267, 271, 1032-1455, 1810-1827, 1842-2265, 2620-2643, 2742-2792.
10/02/14
20140298538
Axmi205 variant proteins and methods of use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided.
10/02/14
20140298510
Manipulation of dominant male sterility
Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and fragments and variants thereof, which modulate male fertility.
10/02/14
20140298508
Alpha-mannosidases from plants and methods for using the same
The present invention is directed to alpha-mannosidase sequences from plants and the use thereof, especially genomic nucleotide sequences containing the regulatory elements controlling their expression, intron and exon sequences and polynucleotide sequences coding for alpha-mannosidase enzymes. Such plants with modified alpha-mannosidase activity can be used for the production of glycoproteins having an altered saccharide composition of great benefit.
10/02/14
20140298500
Mutant protease biosensors with enhanced detection characteristics
A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the c-terminal portion of the thermostable luciferase to the n-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase.
10/02/14
20140296320
Use of sirna to achieve down regulation of an endogenous gene in combination with the use of a sense construct to achieve expression of a polynucleotide
The present invention relates to the combinatorial use of an sirna targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.. .
10/02/14
20140296142
Gene therapy for diabetic neuropathy using an hgf isoform
The present invention relates to a pharmaceutical composition for the prevention or treatment of diabetic neuropathy, wherein the pharmaceutical composition comprises, as active ingredients, different types of isoforms of hgf or a polynucleotide encoding the isoforms. The present invention is the first invention demonstrating that diabetic neuropathy can be prevented and treated using different types of isoforms of hgf.
10/02/14
20140296111
Protein-immobilizing solid phase, polynucleotide-immobilizing solid phase, and nucleic acid recovery method
A protein-immobilizing solid phase is a protein-immobilizing solid phase comprising an mrna-nucleic acid linker-protein complex, obtained by linking the mrna and the protein encoded by that mrna through the nucleic acid linker, immobilized on the solid phase, wherein the nucleic acid linker has a photocleavage site and a solid phase binding site.. .
10/02/14
20140296080
Methods, systems, and computer readable media for evaluating variant likelihood
A method for evaluating variant likelihood includes: providing a plurality of template polynucleotide strands, sequencing primers, and polymerase in a plurality of defined spaces disposed on a sensor array; exposing the plurality of template polynucleotide strands, sequencing primers, and polymerase to a series of flows of nucleotide species according to a predetermined order; obtaining measured values corresponding to an ensemble of sequencing reads for at least some of the template polynucleotide strands in at least one of the defined spaces; and evaluating a likelihood that a variant sequence is present given the measured values corresponding to the ensemble of sequencing reads, the evaluating comprising: determining a measurement confidence value for each read in the ensemble of sequencing reads and modifying at least some model-predicted values using a first bias for forward strands and a second bias for reverse strands.. .
10/02/14
20140295526
Modified proteases
This invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the present invention relates to methods for altering the expression of proteases in microorganisms, such as bacillus species.
10/02/14
20140295523
Glucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-d-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-d-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-d-glucans or xyloglucans and other plant material containing cellulosic parts.
10/02/14
20140295504
Fungal cells and fermentation processes
The present invention provides an isolated fungal cell that is capable of producing one or more biomass-degrading enzymes and that exhibits increased or decreased expression or copy number of a polynucleotide encoding a ptab-like protein. Also provided is a fermentation processes for producing one or more biomass-degrading enzymes comprising a fungal cells exhibiting increased or decreased expression or copy number of a polynucleotide encoding a ptab-like protein.
10/02/14
20140295493
Polypeptides having protease activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
10/02/14
20140295489
Organic compounds
The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake..
10/02/14
20140295454
Variants of vegfr and their use in the diagnosis and treatment of pregnancy associated medical conditions
An isolated polypeptide comprising an amino acid sequence at least 70% homologous to seq id no: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which specifically binds the isolated polypeptide are also disclosed.
10/02/14
20140295443
Polynucleotide sequences of candida dubliniensis and probes for detection
The present invention relates to identification of centromeric sequences of candida dubliniensis and localization of cdcse4p centromeric histone to the identified region. Also the present invention relates to distinguishing candida dubliniensis from other members of genus candida..
10/02/14
20140295439
Nucleic acid amplification
Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
10/02/14
20140295415
Low cost, disposable molecular diagnostic devices
The invention provides molecular diagnostic test devices and methods for using such diagnostic test devices to detect analytes of biological significance in a patient. The diagnostic test devices are particularly useful for detecting a polynucleotide analyte in a sample obtained from a patient.
10/02/14
20140295408
Compositions, methods, and kits for nucleic acid hybridization
Polynucleotides having a first polynucleotide segment contiguous with a second polynucleotide segment that is downstream to the first, wherein the sequence of the first polynucleotide segment is complementary to the sequence of a first probe segment of a probe for detection of a target nucleic acid sequence, wherein the sequence of the second polynucleotide segment is complementary to the sequence of a second probe segment of the probe, wherein the second probe segment is downstream to the first probe segment, are provided. The polynucleotides may be employed with dual-labeled probes (dlps) in assays for the detection of the target nucleic acid sequences..
10/02/14
20140295027
Polypeptides having protease activity
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides in e.g.
10/02/14
20140294848
Novel targets for regulation of angiogenesis
The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of angiogenesis and the diagnosis and treatment of angiogenesis-related diseases such as cancer..
10/02/14
20140294837
Fusion protein comprising anti-c-met antibody and vegf-binding fragment
There are provided a fusion protein formed by coupling of anti-c-met antibody and vegf-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-met and vegf at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-met antibody with a vegf-binding fragment.. .
10/02/14
20140294821
Factor viii chimeric and hybrid polypeptides, and methods of use thereof
The present invention provides methods of administering factor viii (processed fviii, single chain fviii, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising factor viii; chimeric and hybrid polypeptides comprising factor viii; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells. .
10/02/14
20140294782
Reprogramming of cellular adhesion
Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds and compositions in research and therapeutic applications..
09/25/14
20140289908
Gene combinations for producing punicic acid in transgenic plants
Transgenic plants with enhanced punicic acid accumulation result from over-expression of pgfadx and pgfad2, and optionally, one or more of pgdgat1, pgdgat2, and pgpdat1. The invention also relates to novel isolated punica granatum diacylglycerol acyltransferases: type 1 (pgdgat1), type 2 (pgdgat2) and phospholipid:diacylglycerol acyltransferases (pgpdat1); polynucleotide sequences encoding the dgats and pdat enzymes; polynucleotide constructs, vectors and host cells incorporating the polynucleotide sequences; and methods of producing and using same..
09/25/14
20140289906
Compositions having dicamba decarboxylase activity and methods of use
Compositions and methods comprising polynucleotides and polypeptides having dicamba decarboxylase activity are provided. Further provided are nucleic acid constructs, host cells, plants, plant cells, explants, seeds and grain having the dicamba decarboxylase sequences.
09/25/14
20140289905
Polypeptides having xylanase activity and polynucleotides encoding same
Provided are isolated polypeptides having xylanase activity, catalytic domains and cellulose binding domains, and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains..
09/25/14
20140289901
Modulating beta-damascenone in plants
A mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a neoxanthin synthase and having at least 60% sequence identity to seq id no:1 or seq id no. 6; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide having at least 66% sequence identity to seq id no:2 or at least 60% sequence identity to seq id no.
09/25/14
20140289900
Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
Provided are isolated polynucleotides at least 80% identical to seq id nos: 1-479, 813-5173, 8511, 8513, 8515, 8517, 8519, 8521, 8523, 9096-9141 and 9142; and isolated polypeptides at least 80% homologous to an amino acid sequence selected from the group consisting of seq id nos: 624, 480-623, 625-812, 5174-7015, 7017-7021, 7024, 7026-8510, 8512, 8514, 8516, 8518, 8520, 8522, 8524, 9143-9177, such as the polypeptides set forth in seq id no:480-812, 5174-8510, 8512, 8514, 8516, 8518, 8520, 8522, 8524, and 9143-9177, nucleic acid constructs comprising same, transgenic cells and plants expressing same and methods of using same for increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, nitrogen use efficiency, and/or abiotic stress tolerance of a plant.. .
09/25/14
20140289881
Double-stranded rna
The present disclosure provides methods and compositions relating to a polynucleotide comprising a dsrna region that is complementary to a particular region of the ns1 gene segment in the influenza virus genome that targets a sequence comprising two overlapping reading frames, one encoding ns1 and the second encoding the nep polypeptide. Thus, the polynucleotide of the invention is able to target two message rnas and is effective at inhibiting the replication of influenza virus in a cell..


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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