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Polynucleotide patents

      

This page is updated frequently with new Polynucleotide-related patent applications.




 Method for reducing dephasing during cluster dna sequencing patent thumbnailnew patent Method for reducing dephasing during cluster dna sequencing
A method for nucleic acid sequencing, comprising: exposing a plurality of clusters of a plurality of template polynucleotide strands to a series of flows of a plurality of nucleotide or oligonucleotide solutions, wherein the nucleotide solutions or oligonucleotide solutions are flowed in an order of flow which is not a continuous repeat of an ordering of a single flow of each of the nucleotide solutions or oligonucleotide solutions; and obtaining a fluorescence signal indicative of which, if any, nucleotide species or oligonucleotide species incorporated to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands. This method enables dephased amplicons to return in-phase..

 Methods and compositions for isolating polynucleotides patent thumbnailnew patent Methods and compositions for isolating polynucleotides
Methods of isolating target double-stranded polynucleotides with internal single-stranded regions are provided. Compositions and kits comprising double-stranded polynucleotides with internal single-stranded regions are also provided..
Swift Biosciences, Inc.


 Novel dna-binding proteins and uses thereof patent thumbnailnew patent Novel dna-binding proteins and uses thereof
Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel dna-binding domains, including tale dna-binding domains. Also disclosed are methods of using these novel dna-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences..
Sangamo Biosciences, Inc.


 Hppd variants and methods of use patent thumbnailnew patent Hppd variants and methods of use
In particular, isolated polynucleotides encoding hppd inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed..

 Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having alpha-glucuronidase activity, catalytic domains and polynucleotides encoding the polypeptides, catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains..
Novoyzmes A/s


 Polypeptides with lipase activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides with lipase activity and polynucleotides encoding same
Provided are isolated polypeptides with lipase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the polypeptides..
Novozymes A/s


 Tetracycline resistant eukaryotic cells expressing an nadp-requiring oxidoreductase patent thumbnailnew patent Tetracycline resistant eukaryotic cells expressing an nadp-requiring oxidoreductase
Tetx, a tetracycline degrading enzyme, is provided as a selection marker for eukaryotic cells. polynucleotide molecules containing tetx and dna constructs comprising a tetx under the control of a eukaryotic promoter are provided.
Instituto Tecnológico Y De Estudios Superiores De Monterrey


 Polypeptides having alpha amylase activity patent thumbnailnew patent Polypeptides having alpha amylase activity
The present invention relates to polypeptides having alpha-amylase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


 Nucleic acids encoding human antibodies to sialyl-lewis a patent thumbnailnew patent Nucleic acids encoding human antibodies to sialyl-lewis a
The present invention provides compositions for the production of an antibody or functional fragment thereof directed against sialyl-lewisa (slea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to slea.
Mabvax Therapeutics, Inc.


 Human antigen binding proteins that bind betta-klotho, fgf receptors and complexes thereof patent thumbnailnew patent Human antigen binding proteins that bind betta-klotho, fgf receptors and complexes thereof
The present invention provides compositions and methods relating to or derived from antigen binding proteins activate fgf21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-klotho; (ii) fgfr1c, fgfr2c, fgfr3c or fgfr4; or (iii) a complex comprising β-klotho and one of fgfr1c, fgfr2c, fgfr3c, and fgfr4.
Amgen Inc.


new patent

Cd86 antagonist multi-target binding proteins

This disclosure provides a multi-specific fusion protein composed of a cd86 antagonist binding domain and another binding domain that is an il-10 agonist, an hla-g agonist, an hgf agonist, an il-35 agonist, a pd-1 agonist, a btla agonist, a light antagonist, a gitrl antagonist or a cd40 antagonist. The multi-specific fusion protein may also include an intervening domain that separates the other domains.
Aptevo Research And Development Llc

new patent

Recombinant human interferon-like proteins

This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology in described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon like alpha 2b (huifn-α2b).
Novagen Holding Corporation

new patent

Neuronal viability factor and use thereof

The present invention concerns a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected in the group comprising (i) a polypeptide comprising an amino acid sequence selected in the group comprising the amino acid sequence of the long isoform in homo sapiens of the rdcvf2 gene (seq id no: 10), orthologs, derivatives and fragments thereof, (ii) a polynucleotide coding for said polypeptide, (iii) a vector comprising said polynucleotide, and (iv) a host cell genetically engineered expressing said polypeptide; the use of such a composition for the manufacture of a medicament for treating and/or preventing a neurodegenerative disorder in a subject; and a method of testing a subject thought to have or be predisposed to having a neurodegenerative disorder.. .
Centre National De La Recherche Scientifique - Cnrs

Novel fusion and detection the same

A polynucleotide, which is a novel causative gene for cancer, is elucidated, and, based on this finding, provided are a method for detecting the polynucleotide, or a polypeptide encoded by the polynucleotide; a kit and a primer set for the detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for treating a cancer containing the inhibitor. In the detection method of the present invention, an fgfr3 fusion protein, or a fusion gene encoding the fusion protein, or a tacc3 fusion protein, or a fusion gene encoding the fusion protein, is detected in a sample derived from female genitalia obtained from a subject..
Japanese Foundation For Cancer Research

Molecular dynamic sequencing

The present invention relates to a method of identifying a nucleotide at a defined position and determining the sequence of a target polynucleotide using an electro-switchable biosensor, as well as devices comprising an electro-switchable biosensor and uses thereof.. .
Dynamic Biosensors Gmbh

Multiplexed linking pcr

The invention provides compositions and methods for rapid assembly of one or more assembled polynucleotides from a plurality of component polynucleotides, as well as methods of designing polynucleotide primer and linker sets useful in the assembly methods of the invention.. .
The Regents Of The University Of Colorado, A Body Corporate

Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same

Provided are methods of increasing tolerance of a plant to abiotic stress, and/or increasing biomass, growth rate, vigor and/or yield of a plant. The methods are effected by expressing within the plant an exogenous polynucleotide encoding a polypeptide comprising an amino acid sequence at least 90% homologous to the amino acid sequence selected from the group consisting of seq id nos:201, 207, 212, 202-206, 208-211, 213-391, 1655, 961-1529, and 1660-1663.
Evogene Ltd.

Regulatory polynucleotides and uses thereof

The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants.
Monsanto Technology Llc

Chimeric promoters for use in plants

The present invention provides polynucleotide molecules useful for expressing transgenes in plants. The present invention also provides expression constructs containing the polynucleotide molecules useful for expressing transgenes in plants.
Monsanto Technology Llc

Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them

This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., d-amino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: d-alanine+2-oxoglutarate<=>pyruvate+d-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: d-amino acid+h2o+acceptor<=>a 2-oxo acid+nh3+reduced acceptor.. .
Basf Enzymes Llc

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited

Mucin derived polypeptides

The present technology relates to isolated muc17, muc3 or muc3 derived polypeptides and polynucleotides encoding the same. The muc17, muc3 or muc3 derived polypeptides and polynucleotides can be used to treat gastrointestinal tract diseases and disorders.
Mucimed, Inc.

Polypeptide libraries with a predetermined scaffold

Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence exxxaxxeix xlpnltxxqx xafixklxdd psqssellse akklndsq (seq id no: 1) or akyakexxxaxx eixxlpnltx xqxxafixkl xddpsqssel lseakklnds q (seq id no: 2), wherein each x individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed.
Affibody Ab

Combination anti-hiv vectors, targeting vectors, and methods of use

Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a ccr5 rnai; and an expression control element that regulates expression of the nucleic acid encoding the ccr5 rnai element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding trim5 alpha and hiv tar decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides.
The Regents Of The University Of California

Peptide/beta-1,3-glucan complex and production method thereof and pharmaceutical composition containing peptide/beta-1,3-glucan complex

This peptide/β-1,3-glucan complex includes β-1,3-glucan and a peptide/polynucleotide conjugate in which an antigenic peptide is bonded covalently to a polynucleotide or a derivative thereof. The polynucleotide or derivative thereof of the peptide/polynucleotide conjugate bonds via a hydrogen bond with β-1,3-glucan, forming a complex having a triple helix structure including a single molecular chain of the polynucleotide or derivative thereof and two molecular chains of the β-1,3-glucan.
Japan Science And Technology Agency

Compositions and methods for screening t cells with antigens for specific populations

Compositions and methods for isolating patient-derived antigen-specific t cells include an antigen complex having a polynucleotide barcoded nanoparticle sorting agent complexed with a peptide-loaded streptavidin major histocompatability complex (mhc) tetramer, the barcoding technology allowing for high fidelity screening of a library of the antigen complexes to readily isolate and identify antigen-specific t cells.. .
California Institute Of Technology

Method for controlling the movement of a polynucleotide through a transmembrane pore

The invention relates to new methods of controlling the movement of polynucleotides through transmembrane pores. The invention also relates to new methods of characterising target polynucleotides using helicases..
Oxford Nanopore Technologies Ltd.

Parthenocarpy regulation gene and use thereof

In order to identify a novel gene responsible for parthenocarpy and to provide use of the gene, the parthenocarpy regulatory gene of the present invention includes a polynucleotide (1) that encodes an amino acid sequence represented by seq id no: 1, (2) that encodes an amino acid sequence (i) having a sequence identity of 75% or higher relative to the amino acid sequence represented by seq id no: 1, (3) that encodes an amino acid sequence in which 1 to 98 amino acids are substituted, etc. In the amino acid sequence represented by seq id no: 1, or (4) that is hybridized with a polynucleotide, which has a sequence complementary to the polynucleotide for encoding the amino acid sequence represented by seq id no: 1 under a stringent condition..
Takii & Co., Ltd.

Composition for reducing cellular senescence level including activity inhibitor inhibiting dcun1d3 activity or expression inhibitor inhibiting expression of dcun1d3-encoding gene and use thereof

Provided is a composition and method for reducing a cellular senescence level by inhibiting the activity or expression of one or more of dcun1d3 protein or gene encoding same and a polynucleotide having a nucleotide sequence of seq id no: 5, as well as a method of treating a disease or a disease symptom associated with an increased cellular senescence level in a mammal.. .
Samsung Electronics Co., Ltd.

Modified glucosyltransferases for producing branched alpha-glucan polymers

Glucosyltransferase enzymes are disclosed herein that produce branched alpha-glucan polymer. Also disclosed, for example, are polynucleotides encoding these enzymes, as well as methods of producing branched alpha-glucan polymer..
E I Du Pont De Nemours And Company

Ketoreductase polypeptides for the production of azetidinone

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds..
Codexis, Inc.

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited

Polynucleotides for the in vivo production of antibodies

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding an antibody, variant or fragment.. .
Moderna Therapeutics, Inc.

Mesenchymal stem cells for targeted cancer therapy

An isolated polynucleotide comprising the element of: a promoter element that drives expression of the c—c motif ligand 5 (“a ccl5 promoter”) operatively linked to a polynucleotide encoding a fusion polypeptide comprising the fc and hinge regions of a human igg cd44 variant 6 (cd44v6) polypeptide is described.. .
The Regents Of The University Of California

Methods to determine the presence of an antibody that binds modified human thymic stromal lymphopoietin (tslp)

Modified, furin resistant human tslp polypeptides and polynucleotides encoding the modified human tslp polypeptides are provided. Pharmaceutical compositions, b and t cell activation agents, assays and methods of use are also described..
Immunex Corporation

Chemically modified polynucleotides and producing chemically modified polynucleotides

The present invention relates to chemically-modified polynucleotides of formula (i): 5′-cons-seq.id.n-cons-3′ (i) containing one or more modified pyrimidines and at least one inverted nucleotide repeat, and to the method for producing the same.. .
Universidade De Sao Paulo

Peroxygenase variants

The present invention relates to peroxygenase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s

Ketoreductase polypeptides

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4s)-2-oxo-4-phenyl (1,3-oxazolidin-3-yl))-1-(4-fluorophenyl) pentane-1,5-dione to (4s)-3-[(5s)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4s)-3-[(5s)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making ezetimibe..
Codexis, Inc.

Nucleic acids and polypeptides for utilizing plant biomass

The present invention relates to novel nucleic acids, novel groups of polypeptides encoded by the polynucleotides, novel compositions, and methods of using the same with lignin containing substrates.. .
Metamixis, Inc.

Protease enzyme and uses thereof

The present invention is related to a fungal serine protease enzyme, which said enzyme has serine protease activity and comprises an amino acid sequence of malbranchea alko4122 mature protease as defined in seq id no:18 or an amino acid sequence having at least 66% identity to the amino acid sequence of seq id no:18. Also disclosed is an isolated nucleic acid molecule, comprising a polynucleotide sequence which encodes a fungal serine protease enzyme, nucleic acid sequences encoding said protease, a host cell and a process of producing a polypeptide having serine protease activity.
Ab Enzymes Oy

Polynucleotides for treating oncogenic viral polypeptide positive tumors

This document relates to polynucleotides encoding antigenic polypeptides to induce an immune response to oncogenic viral polypeptides. Also provided are compositions comprising polynucleotides encoding antigenic polypeptides, and methods of use.
Sanford Health

Modified polynucleotides for the production of secreted proteins

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.

Novel fgfr3 fusion

The present invention aims to elucidate a polynucleotide as a novel responsible gene for cancer and aims to thus provide a method for detecting the polynucleotide and a polypeptide encoded by the polynucleotide and a detection kit, a probe set, and a primer set for the detection. The present invention also aims to provide a pharmaceutical composition for treating cancer.
Astellas Pharma Inc.

Fluorophore-based oligonucleotide probes with a universal element

There is provided a method of detecting the presence of a target polynucleotide and/or sequence variations within the target polynucleotide using a probe system comprising two independent partner oligonucleotide components wherein the first oligonucleotide has a first and second section, wherein the first section comprises a nucleotide sequence that is labelled with at least one visually detectable label and is not capable of hybridising to the nucleotide sequence of the target polynucleotide; and wherein the second section comprises a nucleotide sequence that is capable of hybridising to a portion of the sequence of the target polynucleotide; and the second oligonucleotide has a first and second section, wherein the first section comprises a nucleotide sequence which is capable of hybridising to a nucleotide sequence of the first section of the first oligonucleotide; and the second section comprises a nucleotide sequence that is capable of hybridising to a nucleotide sequence of the target polynucleotide that is adjacent to the nucleotide sequence that the second section of the first oligonucleotide is capable of hybridising to. There are also provided alternative methods using additional oligonucleotides and probes for use in such methods..
University Of Southampton

Microorganism with improved l-threonine producing capability, and producing l-threonine by using the same

The present invention relates to a novel variant rna polymerase sigma factor 70 (π70) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing l-threonine by using the microorganism.. .
Cj Cheiljedang Corporation

Polypeptides having peroxygenase activity

The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s

Drought tolerant plants and related constructs and methods involving genes encoding dtp4 polypeptides

Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring stress tolerance are presented herein, along with compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a dtp4 polypeptide..
E. I. Du Pont De Nemours And Company

Nucleotide sequence encoding wuschel-related homeobox4 (wox4) protein from corchorus olitorius and corchorus capsularis and methods of use for same

The present invention discloses isolated polynucleotides encoding wuschel-related homeobox4 proteins from two species of jute plants, namely, the corchorus olitorius (“c. Olitorius”) and corchorus capsularis (“c.

Antisense polynucleotides to induce exon skipping and methods of treating dystrophies

Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as limb-girdle muscular dystrophy.. .
The University Of Chicago

Truncated pullulanases, methods of production, and methods of use thereof

Truncated pullulanases having an n-terminal deletion in a parental pullulanase are provided. These truncated pullulanases have altered properties as compared to the parental pullulanase, including an increased saccharification rate and higher catalytic activity at acidic ph values below 4.5 and higher temperatures of up to 64° c.
Nanjing Bestzyme Bio-engineering Co., Ltd.

Polypeptides having cellobiohydrolase activity and polynucleotides encoding same

The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.

Alpha-amylase variants and polynucleotides encoding same

The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes..
Novozymes North America, Inc.



Polynucleotide topics:
  • Nucleotide
  • Polynucleotide
  • Polypeptide
  • Antagonist
  • Nucleic Acid
  • Cancer Cell
  • Drug Resistance
  • Chromosome
  • Glycoprotein
  • Gastrointestinal
  • Gastrointestinal Stromal Tumors
  • Gastrointestinal Stromal Tumor
  • Cellobiohydrolase
  • Human Disease
  • Inflammation


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    This listing is a sample listing of patent applications related to Polynucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Polynucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.


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