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Polynucleotide patents



      

This page is updated frequently with new Polynucleotide-related patent applications.




Date/App# patent app List of recent Polynucleotide-related patents
04/28/16
20160115544 
 Molecular barcoding for multiplex sequencing patent thumbnailMolecular barcoding for multiplex sequencing
Described herein are methods, compositions and kits for preparing samples for multiplex next generation nucleic acid sequencing. The methods entail the use of in-line barcodes that minimize barcode-confusing chimeras, purification procedures with low cost, and/or a quantitative amplification to generate a desired amount of polynucleotides for sequencing..
Athena Diagnostics, Inc.


04/28/16
20160115536 
 Methods for estimating the size of disease-associated polynucleotide repeat expansions in genes patent thumbnailMethods for estimating the size of disease-associated polynucleotide repeat expansions in genes
Methods for estimating the size of disease-associated polynucleotide repeat expansions in genes are disclosed which use restriction enzymes that do not cut within a repeat expansion and which are frequent cutting restriction enzymes that cut genomic dna outside of the expansion into fragments of a size below the threshold capable of detection. A hybridisation probe that can bind to multiple sites within the expansion is then used to estimate its length and to correlate that to the diagnosis or prognosis of disease..
Medical Research Council


04/28/16
20160115522 
 Mutant protease biosensors with enhanced detection characteristics patent thumbnailMutant protease biosensors with enhanced detection characteristics
A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the c-terminal portion of the thermostable luciferase to the n-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase.
Promega Corporation


04/28/16
20160115507 
 Novel o-phosphoserine export protein and the  producing o-phosphoserine using the same patent thumbnailNovel o-phosphoserine export protein and the producing o-phosphoserine using the same
The present invention relates to a novel isolated polypeptide having the ability to export o-phosphoserine (ops) that is a precursor of l-cysteine, a vector comprising the polynucleotide, an ops-producing microorganism having enhanced activity of the polypeptide, a method of producing ops using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting ops, produced by the above method, with a sulfide in the presence of o-phosphoserine sulfhydrylase (opss) or a microorganism that expresses opss.. .
Cj Cheiljedang Corporation


04/28/16
20160115501 
 Direct transfer of polynucleotides between genomes patent thumbnailDirect transfer of polynucleotides between genomes
The present invention provides methods for directly transferring a recombinant polynucleotide of interest from the chromosome of a prokaryotic donor cell to the chromosome of a prokaryotic recipient cell of another species, wherein the polynucleotide of interest comprises at least one coding sequence of interest, preferably one gene of interest and a selectable marker, wherein said polynucleotide of interest in the chromosome of the donor cell is flanked on each side by a polynucleotide region derived from the chromosome of the recipient cell, and wherein the flanking polynucleotide regions are of sufficient size and sequence identity to allow double homologous recombination with the corresponding regions in the chromosome of the recipient cell.. .
Novozymes A/s


04/28/16
20160115465 
 Compositions and methods of use patent thumbnailCompositions and methods of use
The present compositions and methods relate to a beta-mannanase from bacillus hemicellulosilyticus, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (ggm) and/or glucomannan (gm)..
Danisco Us Inc.


04/28/16
20160115463 
 Codon modified amylase from bacillus akibai patent thumbnailCodon modified amylase from bacillus akibai
The present invention relates to an isolated synthetic polynucleotide encoding the mature amylase ax856 from bacillus akibai, using codon modified polynucleotide constructs for the expression of the amylase.. .
Novozymes A/s


04/28/16
20160115460 
 Mutant dna polymerases and methods of use patent thumbnailMutant dna polymerases and methods of use
The present invention provides mutant dna polymerases, polynucleotides encoding the polymerases, cassettes and vectors including such polynucleotides, and cells containing the polymerases, polynucleotides, cassettes, and/or vectors of the invention. The present invention also provides methods for synthesizing polynucleotides and kits including a dna polymerase of the invention..
Applied Biosystems, Llc


04/28/16
20160115459 
 Chimeras of brucella lumazine synthase and beta subunit of ab5 toxins patent thumbnailChimeras of brucella lumazine synthase and beta subunit of ab5 toxins
Chimeric polypeptides useful as immunogens for inducing protective immune responses and neutralizing antibodies against shiga toxin (stx) in mammals. More specifically, chimeric polypeptides having a monomer of the homopentameric b subunit of the shiga 2 toxin fused to the n-terminus of a monomer of brucella lumazine synthase, and to oligomeric protein complexes formed from said chimeric polypeptides.
Inmunova S.a.


04/28/16
20160114042 
 Amine-containing lipidoids and uses thereof patent thumbnailAmine-containing lipidoids and uses thereof
Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems.
Massachusetts Institute Of Technology


04/28/16
20160114035 

Pan-dr binding polypeptides and uses thereof


The present invention provides novel artificial oligopeptides capable of binding hla class ii molecules encoded by several alleles. The oligopeptides include the sequence ax1fvaax2tlx3ax4a (seq id no:1), wherein x1 is selected from the group consisting of w, f, y, h, d, e, n, q, i and k; x2 is selected from the group consisting of f, n, y and w; x3 is selected from the group consisting of h and k, and x4 is selected from the group consisting of a, d and e, with the proviso that the oligopeptide sequence is not akfvaawtlkaaa.
Epimmune Inc.


04/28/16
20160114018 

Imp-3 epitope peptides for th1 cells and vaccines containing the same


Isolated imp-3-derived epitope peptides having th1 cell inducibility are disclosed herein. Such peptides can be recognized by mhc class ii molecules and induce th1 cells.
Oncotherapy Science, Inc.


04/28/16
20160114016 

Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities


Isolated glycyl-trna synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.. .
Atyr Pharma, Inc.


04/28/16
20160114011 

Modified polynucleotides for the production of nuclear proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


04/28/16
20160114007 

Composition for preventing or treating autoimmune disease, comprising, as active ingredient, pink1 protein or polynucleotide encoding same


The present invention relates to a composition for preventing or treating an autoimmune disease comprising, as an active ingredient, pink1 protein or polynucleotide encoding the same. The pink1 protein according to the present invention inhibits the activity of th17, promotes the activity of a regulatory t cell (treg), and increases autophagy in treg cells, thereby controlling excessive immune responses.
Catholic University Industry Academic Cooperation Foundation


04/28/16
20160113287 

Novel nylanderia pubens virus


At least one novel virus capable of infecting crazy ants (nylanderia fulva) is isolated, along with polynucleotide sequences and amino acid sequences of the virus. The virus is capable of be used as a biopesticide to control populations of crazy ants..
The United States Of America As Represented By The Secretary Of Agriculture


04/21/16
20160108463 

Biological specimen collection and transport system


Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay.

04/21/16
20160108434 

Photocatalytic hydrogen production and polypeptides capable of same


An isolated polypeptide comprising a hydrogen generating enzyme attached to a heterologous ferredoxin is disclosed, as well as polynucleotides encoding same, nucleic acid constructs capable of expressing same and cells expressing same. A method for generating hydrogen using the isolated polypeptide is also disclosed..

04/21/16
20160108427 

Proteins toxic or inhibitory to lepidopteran insects


Nucleotide sequences are disclosed encoding novel, insecticidal tic2160 and tic3244 proteins, and variants thereof, and related proteins exhibiting lepidopteran inhibitory activity, as well as fragments thereof. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing a polynucleotide construct encoding one or more of the toxin proteins within the tic2160-related protein toxin class..

04/21/16
20160108426 

Lepidopteran-active cry1da1 amino acid sequence variant proteins


Engineered cry1da amino acid sequences are provided that exhibit improved lepidopteran insecticidal activity and an enhanced lepidopteran spectrum compared to the naturally occurring cry1da protein toxin. polynucleotide sequences intended for use in expression of the improved proteins in plants are also provided.

04/21/16
20160108425 

Compositions and methods for insecticidal control of stinkbugs


Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pentatomidae plant pest, decrease the expression of a target sequence in the pest. The present invention provides various target polynucleotides set forth in any one of seq id nos: 6-12, 18-40 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).

04/21/16
20160108415 

Manipulation of glutamine symthetases (gs) to improve nitrogen use efficiency and grain yield in higher plants


The present invention provides polynucleotides and related polypeptides of the protein gs. The invention provides genomic sequence for the gs gene.

04/21/16
20160108412 

Modified frt recombination site libraries and methods of use


Methods and compositions using populations of randomized modified frt recombination sites to identify, isolate and/or characterize modified frt recombination sites are provided. Kits comprising the library populations of frt sites are also provided, as are methods to make a library of modified frt recombination sites.

04/21/16
20160108395 

Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent


Chimeric single-stranded polynucleotides and double-stranded antisense agents useful for modifying the expression of a target gene by means of an antisense effect are disclosed. The chimeric single-stranded antisense polynucleotide and double-stranded antisense agents comprise a central nucleotide region flanked by a first 5′-wing region and a first 3′-wing region of modified nucleotides, which are themselves flanked by a second 5′-wing region and/or a second 3′-wing region of nucleotides that have a low affinity for proteins and/or that have higher resistance to dnase or rnase than a natural dna or rna and are missing in a cell when the chimeric polynucleotide delivered.

04/21/16
20160108388 

Novel metalloproteases


Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.. .

04/21/16
20160108387 

Novel metalloproteases


Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.. .

04/21/16
20160108386 

Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them


The invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, β-xylosidase, arabinofuranosidase, and/or oligomerase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts.

04/21/16
20160108384 

Amylases, nucleic acids encoding them and methods for making and using them


In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars..

04/21/16
20160108383 

Hydrolases, nucleic acids encoding them and methods for making and using them


Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils..

04/21/16
20160108379 

Actriib-fc polynucleotides, polypeptides, and compositions


In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The present invention also provides methods of screening compounds that modulate activity of an actrii protein and/or an actrii ligand.

04/21/16
20160106823 

Immunity induction agent


Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of seq id nos: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

04/14/16
20160103127 

Methods for detecting a mycobacterium tuberculosis infection


Methods for detecting an infection with mtb in a subject are disclosed. The methods include detecting the presence of cd8+ t cells that specifically recognize an mtb polypeptide.

04/14/16
20160103093 

Apparatuses, methods, systems, and computer-readable media for fluid potential artifact correction in reagent delivery systems


A method for correcting nucleotide incorporation signals for fluid potential effects or disturbances arising in nucleic acid sequencing-by-synthesis includes: disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, the template polynucleotide strands having a sequencing primer and a polymerase bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed through a fluid manifold, the fluid manifold comprising passages for flowing nucleotide species and a branch passage for flowing a solution, the branch passage comprising a reference electrode and a sensing electrode; obtaining a plurality of nucleotide incorporation signals corresponding to the plurality of defined spaces, the nucleotide incorporation signals having a signal intensity related to a number of nucleotide incorporations; and correcting at least some of the plurality of nucleotide incorporation signals for fluid potential effects or disturbances.. .

04/14/16
20160102353 

Polymorphisms associated with age-related macular degeneration and methods for evaluating patient risk


The present invention provides for certain polynucleotide sequences that have been correlated to amd. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an array, useful for screening patient samples.

04/14/16
20160102349 

Methods for sequencing polynucleotides


The invention relates to methods and systems for sequencing and constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are determined at the ends of restriction fragments produced by a plurality of digestions with a plurality of combinations of restriction endonucleases so that a pair of nucleotide sequences is obtained for each restriction fragment.

04/14/16
20160102323 

A laglidadg homing endonuclease cleaving the c-c chemokine receptor type-5 (ccr5) gene and uses thereof


Disclosed herein are compositions for inactivating the human ccr5 gene comprising engineered laglidadg homing endonucleases (lhes) and their derivatives, particularly derived from members of the \-onui subfamily of lhe. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefrom are also provided..

04/14/16
20160102315 

Methods for producing polypeptides in enzyme-deficient mutants of fusarium venentatum


The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent fusarium venenatum strain in a medium for the production of the polypeptide, wherein the mutant strain comprises a polynucleotide encoding the polypeptide and one or more (several) genes selected from the group consisting of pyrg, amya, and alpa, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of orotidine-5′-monophosphate decarboxylase, alpha-amylase, and alkaline protease, respectively, compared to the parent fusarium venenatum strain when cultivated under identical conditions; and (b) recovering the polypeptide from the cultivation medium. The present invention also relates to enzyme-deficient mutants of fusarium venenatum strains and methods for producing such mutants..

04/14/16
20160102311 

Protection against ionizing radiation and chemotherapy toxicity via latexin regulation


The present invention relates to methods for protecting against damage caused by radiation and/or chemotherapy, and methods for treating bone marrow damage by reducing/inhibiting latexin expression and/or latexin activity. The methods comprise administering to a subject in need thereof a pharmaceutical composition comprising an antagonist that reduces expression and/or activity of latexin, wherein latexin is a latexin polynucleotide variant and/or a latexin polypeptide variant that binds to the antagonist..

04/14/16
20160102305 

Polynucleotide capture materials, and methods of using same


Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as rna and/or dna from such samples. The rna and/or dna is captured by polyamindoamine (pamam (generation 0)) bound to a surface, such as the surface of magnetic particles.

04/14/16
20160102299 

Polypeptides encoding mutated mannanases with improved catalytic efficiency


A polypeptide which is a mutated mannanase, whose sequence is derived from a native mannanase of the filamentous ascomycete coprophile fungus podospora anserina, and being characterised by an increased catalyst efficiency of at least 25%. Also, a polynucleotide encoding the polypeptide, a vector including the polynucleotide, a host cell including the vector or the polynucleotide, and a composition including the polypeptide, the polynucleotide, the vector or the host cell.

04/14/16
20160102120 

Galactose cluster-pharmacokinetic modulator targeting moiety for sirna


The present invention is directed compositions for targeted delivery of rna interference (rnai) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone.

04/14/16
20160100548 

Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes


Compositions and methods for reducing the level of nornicotine and n′-nitrosonornicotine (nnn) in nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome p450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants.

04/07/16
20160097092 

Polynucleotide mapping and sequencing


The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as dna or rna, linearizing the biopolymer in some cases, and determining the distance between the labels.
Bionano Genomics, Inc.


04/07/16
20160095918 

Rapid, efficient purification of hsv-specific t-lymphocytes and hsv antigens identified via same


A method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for t lymphocytes that are specific to a virus that attacks skin. Also provided are hsv antigens and epitopes that are useful for the prevention and treatment of hsv infection that have been identified via the methods of the invention.
University Of Washington


04/07/16
20160095916 

Induction of cross-reactive cellular response against rhinovirus antigens


The present invention concerns: a) an isolated peptide comprising an amino acid sequence which is at least 90% identical to the vp4 amino acid sequence of a rhinovirus, or an isolated polynucleotide comprising a nucleic acid sequence encoding said peptide, placed under the control of the elements necessary for its expression in a mammalian cell; and/or b) an isolated peptide comprising an amino acid sequence of at least 100 amino acids which is at least 90% identical to an amino acid sequence located in the last 363 c-terminal amino acids of the rna polymerase of a rhinovirus, or an isolated polynucleotide comprising a nucleic acid sequence encoding said peptide, placed under the control of the elements necessary for its expression in a mammalian cell; and c) a th1 adjuvant when said immunogenic composition comprises one or more of said isolated peptides.. .
Imperial Innovations Limited


03/31/16
20160090623 

Method for pairwise sequencing of target polynucleotides


The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template..
Illumina Cambridge Limited


03/31/16
20160090603 

Delivery platforms for the domestication of algae and plants


The present invention relates to a delivery platform that can be used to genetically modify a target in a plant or an alga. In one instance, polypeptides and/or polynucleotides can be delivered using silica delivery platforms, e.g., silica carriers or protocells.
Sandia Corporation


03/31/16
20160090599 

Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of delta-like (1) homolog (dlk1), in particular, by targeting natural antisense polynucleotides of delta-like (1) homolog (dlk1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression (dlk1)..
Curna, Inc.


03/31/16
20160090585 

Isomerases, nucleic acids encoding them and methods for making and using them


This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention..
Basf Enzymes Llc


03/31/16
20160090577 

Heterologous expression of glycine n-acyltransferase proteins


The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a glycine n-acyltransferase protein (glyat, glyatl 1, glyatl 2, and glyatl 3) for the biosynthesis of n-acylglycine biosurfactants within a heterologous expression system.. .
Dow Agrosciences Llc


03/31/16
20160090407 

Interleukin-2 fusion proteins and uses thereof


The present invention generally relates to fusion proteins of immunoglobulins and interleukin-2 (il-2). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides.
Roche Glycart Ag


03/24/16
20160083761 

Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity, catalytic domains, carbohydrate binding modules and encoding the polypeptides, catalytic domains or carbohydrate binding modules. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules..
Novozymes A/s


03/24/16
20160083759 

Engineered ketoreductase polypeptides


The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Codexis, Inc.


03/24/16
20160083745 

Materials and increasing a plant's resistance to stress


Method of increasing resistance to a pathogen or a pest in a plant comprising introducing into the plant and expressing therein a polynucleotide comprising a nucleotide sequence encoding a qua-quine starch (qqs) polypeptide; method of producing a plant with increased resistance to a pathogen or a pest comprising crossing a plant obtained in accordance with the above method with a second plant to produce progeny plants and selecting progeny plants with increased resistance to a pathogen or a pest; a plant with increased resistance to a pathogen or a pest; a seed of the plant; a hybrid of the plant; and a seed of the hybrid plant.. .
Iowa State University Research Foundation, Inc.


03/24/16
20160083704 

Polypeptides having alpha amylase activity


The present invention relates to polypeptides having alpha-amylaseactivity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


03/24/16
20160083703 

Polypeptides having alpha amylase activity


The present invention relates to polypeptides having alpha-amylase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


03/24/16
20160083700 

Phytase


Polypeptides having phytase activity and polynucleotide sequences encoding the phytases are provided. The gene expresses the phytase at a level of at least 7 g/l to 40 g/l.
Basf Enzymes Llc


03/24/16
20160083441 

Development of protein-based biotherapeutics that penetrate cell-membrane and induce anti-cancer effect - cell-permeable trefoil factor 1 (cp-tff1) in gastrointestinal track (git) cancer, polynucleotides encoding the same, and anti-cancer compositions comprising the same


The present study investigated the use of macromolecule intracellular transduction technology (mitt) to deliver biologically active tff1 protein into gastric cancer cells both in vitro and in vivo. Proteins engineered to enter cancer cells are supposed to suppress cell proliferation and survival, consistent with its role as a tumor suppressor.
Cellivery Therapeutics, Inc.


03/24/16
20160083436 

Non-natural consensus albumin binding domains


Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.. .
Janssen Biotech, Inc.


03/24/16
20160082090 

Use of polysaccharides for promotion of enzymatic activity


This disclosure provides methods and compositions for the promotion of enzymatic activity of target enzymes, including but not limited to oligosaccharide/polysaccharide enzymes, protein enzymes, polynucleotide enzymes. The methods involve use of a non-naturally occurring polysaccharide (including but not limited hes) for promoting the enzymatic activity of an enzyme in liquid milieu, wherein the concentration of the polysaccharide in the composition comprising the target enzyme is from about 0.01% to about 55% w/v..
Genzyme Corporation


03/17/16
20160076108 

Systems and methods for expression-based classification of thyroid tissue


A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from.
Genomedx Biosciences, Inc.


03/17/16
20160076101 

Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and detection


A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide.. .
Institut Pasteur


03/17/16
20160076091 

Nanopore-based nucleic acid analysis with mixed fret detection


Various methods, systems and devices for optical detection and analysis of polymers, such as polynucleotides, using nanopores, e.g., for determining sequences of nucleic acids, are provided herein. In certain variations, methods and systems for determining a nucleotide sequence of a polynucleotide, which include measuring mixed fret signals as a polynucleotide translocates through a nanopore and determining a nucleotide sequence of the polynucleotide from the mixed fret signals, are provided..
Quantapore, Inc.


03/17/16
20160076079 

Novel luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence


Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems..
Promega Corporation


03/17/16
20160076051 

Expression process


A process for the production of a target polypeptide is provided. The process comprises expression of an expression vector for expressing a target polypeptide in a host cell, preferably a mammalian cell, the expression vector comprising an expression cassette comprising a polynucleotide encoding a recombinant polypeptide operably linked to a fibronectin secretion leader sequence; and recovering the target polypeptide..
Fujifilm Diosynth Biotechnologies Uk Limited


03/17/16
20160076050 

Methods of enhancing the resistance of plants to bacterial pathogens


Methods are provided for enhancing the resistance of plants to bacterial pathogens. The methods involve transforming a plant with a polynucleotide molecule comprising a plant promoter operably linked to a nucleotide sequence that encodes a plant receptor that binds specifically with bacterial elongation factor-tu.
Two Blades Foundation


03/17/16
20160076028 

Recombinant adeno-associated virus delivery of exon 2-targeted u7snrna polynucleotide constructs


The present invention relates to recombinant adeno-associated virus (raav) delivery of polynucleotides for treating duchenne muscular dystrophy resulting from the duplication of dmd exon 2. The invention provides raav products and methods of using the raav in the treatment of duchenne muscular dystrophy..
Research Institute At Nationwide Children's Hospital


03/17/16
20160076024 

Compositions and methods for intramolecular nucleic acid rearrangement


Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or mid).
Population Genetics Technologies Ltd.


03/17/16
20160076022 

Nucleic acid linker


The present invention relates to a nucleic acid linker for producing a complex of mrna, and a protein or a peptide which is encoded by the mrna, the linker comprising: a spacer portion at the 5′-terminal; a polynucleotide portion hybridizable with at least a part of a sequence of the mrna; and an arm portion which has a connection portion for the protein or the peptide at the 3′-terminal, in which the spacer portion, the polynucleotide portion, and the arm portion form a single strand, and in which the polynucleotide portion contains a photoreactive base derivative.. .
Nikon Corporation


03/17/16
20160076018 

Long-acting coagulation factors and methods of producing same


Polypeptides comprising at least one carboxy-terminal peptide (ctp) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed..
Opko Biologics Ltd.


03/17/16
20160076012 

Detergent compositions


The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with seq id no: 2, and comprises substitutions at positions corresponding to t231r+n233r and at least one or more (e.g., several) of d96e, d111a, d254s, g163k, p256t, g91t, and g38a of seq id no: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning.
Novozymes A/s


03/17/16
20160076008 

Synthesis of prazole compounds


The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. .
Codexis, Inc.


03/17/16
20160076007 

Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same


The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
Ikeda Food Research Co., Ltd.


03/17/16
20160075810 

Functionalized polymer hybrids


A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.. .
Carnegie Mellon University


03/17/16
20160075785 

Bispecific t cell activating antigen binding molecules


The present invention generally relates to novel bispecific antigen binding molecules for t cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides.
Hoffmann-la Roche Inc.


03/17/16
20160075754 

Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same


(ii) a second domain which comprises an fc domain of an immunoglobulin, wherein the first domain and the second domain are n-terminally to c-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds tnf alpha.. .

03/17/16
20160075752 

B-type plexin antagonists and uses thereof


The present invention concerns the field of cancer therapy. In particular, it relates to an antagonist of a b-type plexin which prevents the interaction of the b-type plexin with erbb-2 for use as a medicament, in particular, for treating metastasizing cancer.
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.


03/17/16
20160075750 

Production of tsg-6 protein


A method of producing a protein or polypeptide, such as, for example, tsg-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells.

03/17/16
20160075733 

Modified polynucleotides for the production of biologics and proteins associated with human disease


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


03/17/16
20160074533 

Vector encoding therapeutic polypeptide and safety elements to clear transduced cells


A composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) activator polynucleotide wherein the modified mammalian tmpk polynucleotide encodes a modified mammalian tmpk polypeptide that increases phosphorylation of a prodrug relative to phosphorylation of the prodrug by wild-type mammalian tmpk polypeptide to a drug; and/or a targeting polynucleotide encoding a cell surface polypeptide that selectively binds a toxic binding agent. The disclosure also relates to use of these compositions in methods of treatment of diseases such as fabry disease..
University Health Network


03/10/16
20160068917 

Adenoviruses and their use


Baboon adenovirus (baadv)-2/4 and baadv-3 are disclosed herein. Baadv-2/4 and baadv-3 polynucleotide, polypeptides and antibodies that specifically bind baadv-2/4 and/or baadv-3 are disclosed.
The Government Of The United States Of America As Represented By The Secretar


03/10/16
20160068865 

Genome editing in rats using zinc-finger nucleases


Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins..
Sangamo Biosciences, Inc.


03/10/16
20160068847 

Polynucleotides having leader sequence function


The present invention relates to isolated polynucleotides having leader sequence function. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods using the polynucleotides for production of polypeptides..
Novozymes A/s


03/10/16
20160068839 

Metal-ligand coordination polymer nanoparticles and methods for making


Disclosed herein are metal-ligand complexes containing polynucleotides, compounds for making the same, and methods of using the same.. .
Northwestern University


03/10/16
20160068836 

Polynucleotides and polypeptide sequences involved in the process of bone remodelling


This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding polypeptides, uses of the polynucleotides, polypeptides, variants and derivatives, and methods and compositions for the amelioration of symptoms caused by bone remodeling disorders. Disclosed in particular are the isolation and identification of polynucleotides polypeptides variants and derivatives involved in osteoclast activity, validation of the identified polynucleotides for their potential as therapeutic targets and use of the polynucleotides, polypeptides, variants and derivatives for the amelioration of disease states and research purposes..
Alethia Biotherapeutics Inc.


03/10/16
20160068832 

Lyase enzymes, nucleic acids encoding them and methods for making and using them


This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
Basf Enzymes Llc


03/10/16
20160068825 

Development of protein-based biotherapeutics that penetrate cell-membrane and induce anti-cancer effect- cell-permeable glutathione peroxidase7 (cp-gpx7) in gastrointestinal track (git), polynucleotides encoding the same, and anti-cancer compositions comprising the same


Gastrointestinal track (git) including oesophageal and gastric cancers are a leading cause of cancer death worldwide. Limited therapeutic options highlight the need to understand the molecular changes responsible for the disease and to develop therapies based on this understanding.
Cellivery Therapeutics, Inc.


03/10/16
20160068606 

Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics


This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against krtcap3, fam26f, mgc52498, fam70a or tmem154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages.
Compugen Ltd.


03/10/16
20160068605 

Cd123 binding agents and uses thereof


Provided herein are antibodies that immunospecifically bind to cd123. Also described are related polynucleotides capable of encoding the provided cd123-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments.
Janssen Pharmaceutica Nv


03/10/16
20160067346 

Brush-poly (glycoamidoamine)-lipids and uses thereof


Which may assist the pgal and/or a complex of the pgal and an agent to pass through cell membranes or be taken up by cells. Also provided are compositions including a described pgal and an agent (e.g., polynucleotide, small molecule, peptide, or protein).

03/03/16
20160060693 

Compositions and methods for intramolecular nucleic acid rearrangement


Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or mid).
Population Genetics Technologies Ltd.


03/03/16
20160060691 

Transposition of native chromatin for personal epigenomics


Provided herein is a method for analyzing polynucleotides such as genomic dna. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic dna; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region.
The Board Of Trustees Of The Leland Stanford Junior University


03/03/16
20160060674 

Nucleic acid amplification


Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
Theranos, Inc.


03/03/16
20160060671 

Synthon formation


This disclosure provides, among other things, a composition comprising: a 5′ exonuclease; a strand-displacing polymerase; and optionally a single strand dna binding protein and/or a ligase. A method for polynucleotide assembly to form a synthon, as well as a kit for performing the same, are also described..
New England Biolabs, Inc.


03/03/16
20160060670 

Polypeptides having cellobiohydrolase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


03/03/16
20160060662 

Desaturases of a green microalga and uses thereof


Isolated proteins which are at least partially encoded by polynucleotide sequences encoding novel desaturases are provided together with a composition which includes these isolated proteins. A transgenic plant, a transgenic alga, or a transgenic seed transformed by the polynucleotides encoding proteins which are at least partially encoded by novel desaturases are also provided.
Ben Gurion University Of The Negev Research And Development Authority


03/03/16
20160060647 

Drought tolerant plants and related constructs and methods involving genes encoding phosphatidic acid phosphatase (pap), dtp25 and dtp46 polypeptides


Isolated polynucleotides, polypeptides and recombinant dna constructs useful for conferring drought tolerance are disclosed. The recombinant dna construct comprises a promoter that is functional in a plant operably linked to a polynucleotide that encodes a pap, a dtp25 or a dtp46 polypeptide.
E I Du Pont De Nemours And Company


03/03/16
20160060609 

Hydrolases, nucleic acids encoding them and methods for making and using them


The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase a, b, c and d activity, patatin activity, lipid acyl hydrolase (lah) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
Dsm Ip Assets B.v.


03/03/16
20160060608 

Lipases, polynucleotides encoding them and their uses


A lipase comprising a polypeptide or peptide comprising an amino acid sequence selected from the group consisting of seq id no: 1-19 and the polynucleotides encoding the lipases is disclosed. The lipases and nucleic acid sequences encoding these lipases can be used in the preparation of polymers, in formulations which may comprise detergents, as catalysts, in the preparation of bioplastics, as part of diagnostic kits, in the preparation of biofuels and for the prevention and/or treatment of a disease..
Aberystwyth University


03/03/16
20160060606 

Acyltransferases and uses thereof in fatty acid production


The present invention pertains to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides.
Basf Plant Science Company Gmbh


03/03/16
20160060327 

Anti-infective binding proteins that bind aip2


There is disclosed compositions and methods relating to or derived from anti-aip2 antibodies. More specifically, there is disclosed fully human antibodies that bind aip2, aip2-binding fragments and derivatives of such antibodies, and aip2-binding polypeptides comprising such fragments.
Sorrento Tharapeutics, Inc.


03/03/16
20160060326 

Antibody therapeutics that bind oprf and oprl


There is disclosed compositions and methods relating to or derived from anti-oprf and anti-opri antibodies. More specifically, there is disclosed fully human antibodies that bind oprf and opri, oprf and opri-antibody binding fragments and derivatives of such antibodies, and oprf and opri-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


03/03/16
20160060323 

Zcytor17 heterodimeric cytokine receptor


Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto..
Zymogenetics, Inc.


03/03/16
20160060319 

Development of protein-based biotherapeutics that induced osteogenesis for bone healing therapy: cell-permeable bmp2 and bmp7 recombinant proteins (cp-bmp2 & cp-bmp7), polynucleotides encoding the same and pro-osteogenic compositions comprising the same


The present invention is about direct protein delivery system for bone morphogenetic proteins (bmps) to enhance bone regeneration without the need of additional delivery carrier which requires open surgery for their implantation. The cell-permeable bmp (cp-bmp) recombinant proteins are fused with advanced macromolecule transduction domain (amtd) to give them ability for cell penetration and with solubilization domain (sd) to increase their solubility and manufacturing yield.
Cellivery Therapeutics, Inc.


03/03/16
20160060314 

Development of a protein-based biotherapeutic agent that penetrates cell-membrane and induces anti-tumor effect in solid tumors - improved cell-permeable suppressor of cytokine signaling (icp-socs3) proteins, polynucleotides encoding the same, and anti-tumor compositions comprising the same


In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. However, systemic protein delivery in vivo has been proven difficult due to poor tissue penetration and rapid clearance.
Cellivery Therapeutics, Inc.


03/03/16
20160060313 

Development of protein-based biotherapeutics that penetrates cell-membrane and induces anti-angiogenic effect - improved cell-permeable suppressor of cytokine signaling (icp-socs3) proteins, polynucleotides encoding the same, and anti-angiogenic compositions comprising the same


In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. However, systemic protein delivery in vivo has been proven difficult due to poor tissue penetration and rapid clearance.
Cellivery Therapeutics, Inc.


03/03/16
20160060312 

Development of protein-based biotherapeutics that penetrates cell-membrane and induces anti-pancreatic cancer effect - improved cell-permeable suppressor of cytokine signaling (icp-socs3) proteins, polynucleotides encoding the same, and anti-pancreatic cancer compositions comprising the same


In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. However, systemic protein delivery in vivo has been proven difficult due to poor tissue penetration and rapid clearance.
Cellivery Therapeutics, Inc.


03/03/16
20160060311 

Development of protein-based biotherapeutics that penetrates cell-membrane and induces anti-lung cancer effect - improved cell-permeable suppressor of cytokine signaling (icp-socs3) proteins, polynucleotides encoding the same, and anti-lung cancer compositions comprising the same


In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. However, systemic protein delivery in vivo has been proven difficult due to poor tissue penetration and rapid clearance.
Cellivery Therapeutics, Inc.


03/03/16
20160060310 

Development of protein-based biotherapeutics that penetrates cell-membrane and induces anti-hepatocellular carcinoma effect - improved cell-permeable suppressor of cytokine signaling (icp-socs3) proteins, polynucleotides encoding the same, and anti-hepatocellular carcinoma compositions comprising the same


Protein transduction exploits the ability of some cell-penetrating peptide (cpp) sequences to enhance the uptake of proteins and other macromolecules by mammalian cells. Previously developed hydrophobic cpps, named membrane translocating sequence (mts), membrane translocating motif (mtm) and macromolecule transduction domain (mtd), are able to deliver biologically active proteins into a variety of cells and tissues.
Cellivery Therapeutics, Inc.


03/03/16
20160060308 

Endoplasmic reticulum localization signals


The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or multimeric form.
Intrexon Corporation


03/03/16
20160060306 

Dig-14 insecticidal cry toxins


Dig-14 insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed.. .
Dow Agrosciences Llc


03/03/16
20160060304 

Sulfonylurea-responsive repressor proteins


Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound.
Pioneer Hi-bred International Inc




Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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