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Polynucleotide patents



      

This page is updated frequently with new Polynucleotide-related patent applications.




Date/App# patent app List of recent Polynucleotide-related patents
07/21/16
20160209350 
 Compositions, devices, systems, and methods for using a nanopore patent thumbnailnew patent Compositions, devices, systems, and methods for using a nanopore
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore.
The Regents Of The University Of California


07/21/16
20160208346 
 Method and composition for detection of oncogenic hpv patent thumbnailnew patent Method and composition for detection of oncogenic hpv
Probes for the detection of oral oncogenic human papillomavirus (hpv) are described. The probe includes a polynucleotide having at least 90% sequence identity to a polynucleotide complementary to a microrna that has altered expression in response to oncogenic hpv infection.
Notre Dame Du Lac


07/21/16
20160208335 
 Use of rhoa in cancer diagnosis and inhibitor screening patent thumbnailnew patent Use of rhoa in cancer diagnosis and inhibitor screening
Disclosed are a novel method of detecting cancer, a method of screening inhibitors and anticancer agents that target cancer-related molecules, rhoa polypeptide having mutation and a polynucleotide encoding the polypeptide as a therapeutic agent for cancer, and a method of detecting cancer using the polypeptide or polynucleotide. Also disclosed are a vector and a host cell comprising the polynucleotide, a method of screening therapeutic agents for cancer comprising the polypeptide and/or the polynucleotide, and a therapeutic agent for cancer comprising sirna having a silencing effect on rhoa mutant..
Chugai Seiyaku Kabushiki Kaisha


07/21/16
20160208301 
 Polypeptides having xylanase activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to polypeptides having xylanase activity and catalytic domains and polynucleotides encoding the polypeptides and catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and catalytic domains..
Novozymes A/s


07/21/16
20160208286 
 Alphaviral vectors and cell lines for producing recombinant proteins patent thumbnailnew patent Alphaviral vectors and cell lines for producing recombinant proteins
The present invention relates to polynucleotides and alphaviral vectors for the expression of genes of interest in mammalian cells. Additionally, the invention relates to cells which comprise said polynucleotides and alphaviral vectors and are capable of stably expressing one or more genes of interest.
3p Biopharmaceuticals, S.l.


07/21/16
20160208272 
 Plant genome modification using guide rna/cas endonuclease systems and methods of use patent thumbnailnew patent Plant genome modification using guide rna/cas endonuclease systems and methods of use
Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide rna/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed.
Pioneer Hi-bred International, Inc.


07/21/16
20160208271 
 Methods for producing genetic modifications in a plant genome without incorporating a selectable transgene marker, and compositions thereof patent thumbnailnew patent Methods for producing genetic modifications in a plant genome without incorporating a selectable transgene marker, and compositions thereof
Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell, without incorporating a selectable transgene marker. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed, without incorporating a selectable transgene marker.
Pioneer Hi-bred International, Inc.


07/21/16
20160208261 
 Methods and compositions for inhibiting the function of polynucleotide sequences patent thumbnailnew patent Methods and compositions for inhibiting the function of polynucleotide sequences
A therapeutic composition for inhibiting the function of a target polynucleotide sequence in a mammalian cell includes an agent that provides to a mammalian cell an at least partially double-stranded rna molecule comprising a polynucleotide sequence of at least about 200 nucleotides in length, said polynucleotide sequence being substantially homologous to a target polynucleotide sequence. This rna molecule desirably does not produce a functional protein.
Alnylam Pharmaceuticals, Inc.


07/21/16
20160208255 
 Rna agents for p21 gene modulation patent thumbnailnew patent Rna agents for p21 gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human p21 using rna interference. The rna interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.
Nitto Denko Corporation


07/21/16
20160208254 
 Rna agents for gst-pi gene modulation patent thumbnailnew patent Rna agents for gst-pi gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human gst-π using rna interference. The rna interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.
Nitto Denko Corporation


07/21/16
20160208234 
new patent

Protease variants and polynucleotides encoding same


The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


07/21/16
20160208229 
new patent

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


07/21/16
20160208019 
new patent

T cell activating bispecific antigen binding molecules


The present invention generally relates to novel bispecific antigen binding molecules for t cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides.
Hoffmann-la Roche Inc.


07/21/16
20160208017 
new patent

Mutant interleukin-2 polypeptides


The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the il-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant il-2 polypeptides, polynucleotide molecules encoding the mutant il-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules.
Roche Glycart Ag


07/14/16
20160202249 

Method for measuring modified nucleobase using absorbent polynucleotide and kit for same


An object of the present invention is to provide a technique that suppresses a background value of a detection signal to construct an immunoassay system for detecting a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample and a capture probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the presence of an absorbent polynucleotide in the obtained solution.
Fujirebio Inc.


07/14/16
20160201147 

Analysis of polynucleotides


According to some embodiments herein, methods and kits for labeling and analyzing nucleic acids are provided. In some embodiments, sequence-specific labeling is performed on polynucleotide sequences associated with a host genome, and the presence or absence of patterns characteristic of extragenomic sequences are determined..
Bionano Genomics, Inc.


07/14/16
20160201146 

Novel reporter constructs for compound screening


The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a dna sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the dna sequence-specific transactivator.
Koch Biological Solutions, Llc


07/14/16
20160201124 

Targeted sequencing and uid filtering


Provided herein are methods, compositions, and kits for targeted sequencing of polynucleotides with high accuracy and low amplification and sequencing errors.. .
Roche Molecular Systems, Inc.


07/14/16
20160201120 

Stable nanoreporters


The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to improved, stable nanoreporter probes that are capable of binding to and identifying target molecules based on the probes' uniquely detectable signal.
Nanostring Technologies, Inc.


07/14/16
20160201119 

Digital analysis of molecular analytes using electrical methods


Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte.
Apton Biosystems, Inc.


07/14/16
20160201099 

Chimeric non-ribosomal peptide synthetase


The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a chimeric non-ribosomal peptide synthetase (nrps) fusion protein for the biosynthesis of n-acylglycine biosurfactants within a heterologous expression system.. .
Dow Agrosciences Llc


07/14/16
20160201085 

Enhancing efficiency of retroviral transduction of host cells


The present invention provides methods for enhancing transduction efficiency of a viral vector into a host cell such as an unstimulated stem cell. The methods involve transducing the host cell with the vector in the presence of an samhd1 inhibitor (e.g., a vpx protein), and an inhibitor of mtor complexes (e.g., rapamycin or analog compound thereof).
The Scripps Research Institute


07/14/16
20160201084 

Wheat ms1 polynucleotides, polypeptides, and methods of use


Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility.
Pioneer Hi Bred International Inc


07/14/16
20160201082 

Axmi422 toxin gene and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
Athenix Corp.


07/14/16
20160201080 

Plant resistant to helminthosporium turcicum


The present invention provides an improved helminthosporium turcicum-resistant plant, in particular a maize plant which comprises a polynucleotide with one or more resistance-conferring genes, for example on a truncated chromosome fragment from the accession pepitilla, as well as a cell, a tissue, a part, grain and seeds thereof, an isolated polynucleotide which comprises one or more resistance-conferring genes against helminthosporium turcicum, a vector, a transgenic plant cell and a transgenic plant containing this polynucleotide. Furthermore, the invention encompasses suitable markers and their use in introducing resistance or the transgene into a plant, as well as the identification of improved maize plants which comprise a truncated chromosome fragment..
UniversitÄt ZÜrich


07/14/16
20160201079 

Polynucleotides and methods for making plants resistant to fungal pathogens


This invention relates to polynucleotide sequences encoding a gene that can confer resistance to the plant pathogen colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to the plant pathogen colletotrichum, and processes of making said plants and seeds.
University Of Delaware


07/14/16
20160201072 

Genome modification using guide polynucleotide/cas endonuclease systems and methods of use


Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a cell or organism.
Pioneer Hi-bred International, Inc.


07/14/16
20160201048 

Stabilized recombinant expression plasmid vector in hafnia alvei and applications thereof


One aspect of the present disclosure relates to a stabilized recombinant expression plasmid vector comprising a polynucleotide encoding an antitoxin gene which expresses a polypeptide that neutralizes a polypeptide toxic to a host cell, the toxic polypeptide being expressed by a toxin gene in the host cell, and a polynucleotide encoding a polypeptide expression product, and the stabilized recombinant expression plasmid vector is derived from a hafnia alvei autonomously replicable backbone plasmid. Other aspects of the present disclosure relate to a transformant transformed with the stabilized recombinant expression plasmid vector disclosed herein, a method of producing biobased cadaverine using the transformant disclosed herein, and biobased cadaverine prepared by the method disclosed herein.
Cathay R&d Center Co., Ltd.


07/14/16
20160201046 

Degradable clostridial toxins


The specification discloses clostridial toxins or clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.. .
Allergan, Inc.


07/14/16
20160201042 

Alpha-amylase variants and polynucleotides encoding same


The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


07/14/16
20160200810 

Bacterial host strain


A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated tsp gene, wherein the mutated tsp gene encodes a tsp protein having reduced protease activity or is a knockout mutated tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a protease iii protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated degp gene encoding a degp protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated tsp gene and/or mutated ptr gene and/or mutated degp gene and optionally a polynucleotide sequence encoding a protein of interest.. .
Ucb Pharma, S.a.


07/14/16
20160200793 

Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy


The present invention provide purified flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.. .
Vegenics Pty Limited


07/14/16
20160200778 

Pesticidal nucleic acids and proteins and uses thereof


The invention provides compositions comprising polynucleotide molecules encoding certain pesticidal polypeptides which exhibit plant parasitic nematode and/or insect control properties, and are particularly directed to controlling plant parasitic pest species of nematodes and insects known to infest crop plant species. Methods for controlling pests are disclosed in which the toxic proteins are provided in the diet of the targeted plant pests.
Monsanto Technology Llc


07/14/16
20160199513 

Modified polynucleotides for the production of proteins associated with human disease


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


07/14/16
20160199474 

Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression


The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to deliver antigens in a manner resembling the live infectious organism in terms of elicitation of a robust immune response, but with reduced risk or no risk of disease. The compositions of the invention are produced by rendering a bacterium bacteriostatic through expression of a recombinant promoter in the bacterial cell, which promoter can be operably linked to a polynucleotide encoding a recombinant gene product.
Gangagen, Inc.


07/14/16
20160199473 

Mesothelin vaccines and model systems


Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic t cell response.
The Johns Hopkins University


07/14/16
20160199472 

Hla-a* 1101-restricted wt1 peptide and pharmaceutical composition comprising the same


An hla-a*1101-restricted wt1 peptide, specifically, a peptide comprising an amino acid sequence consisting of 9 contiguous amino acids from a wt1 protein, wherein the peptide has an ability to bind to an hla-a*1101 molecule, and has an ability to induce a ctl is described. A peptide dimer having an ability to bind to an hla-a*1101 molecule and having an ability to induce a ctl, in which two peptide monomers each comprising an amino acid sequence consisting of 9 contiguous amino acids from a wt1 protein and comprising at least one cysteine residue are bound to each other through a disulfide bond is also described.
International Institute Of Cancer Immunology, Inc.


07/14/16
20160199455 

Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof


The present invention provides methods of administering factor viii; methods of administering chimeric and hybrid polypeptides comprising factor viii; chimeric and hybrid polypeptides comprising factor viii; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.. .
Biogen Hemophilia Inc.


07/14/16
20160199412 

Modified hepatitis post-transcriptional regulatory elements


Provided are polynucleotides containing a modified pre having a variant x gene that includes one or more stop codons not present in an unmodified, such as wild-type, hepatitis x gene. Also provided are polynucleotides containing a modified pre having a variant x gene that includes one or more degradation sequences not present in an unmodified, such as wild-type, hepatitis x gene.
Juno Therapeutics, Inc.


07/07/16
20160194712 

Mirna based treatment monitoring in autoimmune diseases


The invention relates to methods of determining whether a patient responds to a therapeutic treatment of an autoimmune disease, of monitoring the course of an autoimmune disease in a patient, of determining the risk for a relapse of an autoimmune disease in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of an autoimmune disease in a patient. Said methods are based on the determination of the level of at least one mirna in a test sample isolated from the patient.
Comprehensive Biomarker Center Gmbh


07/07/16
20160194691 

Dna mutation detection employing enrichment of mutant polynucleotide sequences and minimally invasive sampling


The invention relates to a method for enriching a target polynucleotide sequence containing a genetic variation said method comprising: (a) providing two primers targeted to said target polynucleotide sequence; (b) providing a target specific xenonucleic acid clamp oligomer specific for a wildtype polynucleotide sequence; (c) generating multiple amplicons using pcr under specific temperature cycling conditions; and (d) detecting said amplicons.. .

07/07/16
20160194686 

Efficient arrays of amplified polynucleotides


The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic dna. The invention provides methods, compositions and systems for such analysis.
Complete Genomics, Inc.


07/07/16
20160194677 

Method


The invention relates to a method for modifying a template double stranded polynucleotide, especially for characterisation using nanopore sequencing. The method produces from the template a plurality of modified double stranded polynucleotides.
Oxford Nanopore Technologies Ltd.


07/07/16
20160194676 

Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans


The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-d-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-d-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-d-glucan synthase-activity or the use of such a polypeptide for producing β-glucans.
Wintershall Holding Gmbh


07/07/16
20160194665 

Methods and compositions for inactivating alpha 1,6 fucosyltransferase (fut8) gene expression


Disclosed herein are methods and compositions for inactivating a fut8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins..
Sangamo Biosciences, Inc.


07/07/16
20160194661 

Exogenous gene expression vector, transformant discrimination marker, and transformant


This invention is intended to develop a promoter that can strongly induce marker gene expression throughout an embryo, so as to simply, efficiently, and accurately identify a transgenic insect at an early developmental stage, and to provide a gene expression vector into which such promoter has been incorporated as a transformant discrimination marker. Such exogenous gene expression vector comprises a polynucleotide comprising the nucleotide sequence as shown in seq id no: 1 as a promoter..
National Institute Of Agrobiological Sciences


07/07/16
20160194659 

Self-reproducing hybrid plants


Compositions and methods for the production of self-reproducing hybrid plants are provided. Compositions include suppression cassettes encoding polynucleotides and promoters that result in the mime diploid gamete phenotype compositions and suppression cassettes and expression cassettes useful for genome elimination of a parental diploid gamete in a fertilized zygote.
Pioneer Hi-bred International Inc.


07/07/16
20160194654 

Plants having increased tolerance to herbicides


The present invention refers to a plant or plant part comprising (i) a recombinant polynucleotide encoding a wildtype or mut-ppo polypeptide, and (ii) a recombinant polynucleotide encoding a cyp450 polypeptide, the expression of said polynucleotides (i) and (ii) confers to the plant or plant part tolerance to ppo-inhibiting herbicides.. .
Basf Agro B.v.


07/07/16
20160194650 

Transcriptional regulation for improved plant productivity


Methods comprising dna constructs and polynucleotides of functional transcription factors for improving photosynthetic capacity, biomass and/or grain yield and stress tolerance in various crop and model plants, dicots and monocots with the c3 or c4 photosynthetic pathways are described herein.. .
Metabolix, Inc.


07/07/16
20160194629 

Scaffolded nucleic acid polymer particles and methods of making and using


The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment.
Life Technologies Corporation


07/07/16
20160194625 

Chimeric polynucleotides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules.. .
Moderna Therapeutics, Inc.


07/07/16
20160194618 

Phytase


Polypeptides having phytase activity and polynucleotide sequences encoding the phytases are provided. The gene expresses the phytase at a level of at least 7 g/l to 40 g/l.
Basf Enzymes Llc


07/07/16
20160194408 

Anti-pcsk9 antibodies and use thereof


The present invention is directed to antibodies and fragments thereof having binding specificity for pcsk9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the vh, vl and cdr polypeptides described herein, and the polynucleotides encoding them.
Alderbio Holdings Llc


07/07/16
20160194369 

Methods and compositions for co-expression of polypeptides of inerest and il6


The present invention provides a cho cell that includes a polynucleotide encoding a polypeptide of interest. The cho cell may include a heterologous polynucleotide encoding il6 and/or an il6 pathway member or, in the absence of the heterologous il6 or an il6 pathway member polynucleotide, the cho cell can be cultured in the presence of exogenously added il6 polypeptide.
Merck Sharp & Dohme Corp.


07/07/16
20160194368 

Circular polynucleotides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.. .
Moderna Therapeutics, Inc.


07/07/16
20160193150 

Reducing or non-reducing polynucleotide polymer for drug delivery and preparing same


The present invention relates to a reducing or non-reducing polynucleotide polymer for drug delivery and a method for preparing same, and provides a reducing or non-reducing polymer synthesized by using nucleotides, a method for preparing same, and a polymer composition for drug delivery containing the reducing or non-reducing polymer. The present invention relates to a drug delivery carrier for delivering proteins or peptides to a targeted area through electrostatic attraction, by obtaining a negatively (−) charged polymer by using nucleotides to synthesize the reducing or non-reducing polymer, which is easily breakable due to disulfide bonds, and then bonding the negatively (−) charged polymer with a positively (+) charged protein or peptide, wherein a polymer derived from a non-viral drug delivery carrier containing the novel reducing or non-reducing polymer is capable of effectively enabling escape of a drug, delivered by means of proton buffering activity, from an endosome to other organelles in a cell..
Utah-inha Dds & Advanced Therapeutics Research Center


06/30/16
20160188795 

Systems and methods for error correction in dna sequencing


Disclosed are systems and methods for polynucleotide sequencing where detection and correction of base calling errors can be achieved without reliance on a reference sequence. In certain embodiments, redundant information can be introduced during measurement so as to allow such detection of errors.

06/30/16
20160188794 

Systems and methods for error correction in dna sequencing


Disclosed are systems and methods for polynucleotide sequencing where detection and correction of base calling errors can be achieved without reliance on a reference sequence. In certain embodiments, redundant information can be introduced during measurement so as to allow such detection of errors.

06/30/16
20160187322 

Feline bitter taste receptors and methods


A family of novel feline bitter taste receptors, referred to as feline tas2r (ftas2r), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors.

06/30/16
20160187276 

Electrochemical nanosensors for biomolecule detection


Sensor devices, methods and kits for detection of biomolecules are provided. According to various embodiments, the devices, methods and kits provide enhanced sensitivity through the measurement of electrochemical impedance and related properties.

06/30/16
20160186268 

Gene defects and mutant alk kinase in human solid tumors


Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of anaplastic lymphoma kinase (alk) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. Non-small cell lung carcinoma (nsclc).

06/30/16
20160186234 

Codon-optimized gene for mutated shrimp luciferase and use thereof


There has been a demand for a codon-optimized gene for the mutated catalytic domain of oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than that of native 19 kda protein.

06/30/16
20160186221 

Compositions and methods of use


The present compositions and methods relate to a beta-mannanase from paenibacillus kribbensis, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (ggm) and/or glucomannan (gm)..

06/30/16
20160186206 

Optimized expression cassette for expressing a polypeptide with high yield


The present invention is based on the finding that the combination of a specific 5′utr polynucleotide sequence (see seq id no 1) and the hcd33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield..

06/30/16
20160186202 

Axmi115 variant insecticidal gene and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be used in dna constructs or expression cassettes for expression in plants and bacteria.

06/30/16
20160186199 

Isolated polynucleotides and polypeptides for increasing plant yield and/or agricultural characteristics


Provided are isolated polynucleotides which comprise a nucleic acid sequence at least 80% identical to seq id no: 321, 1-320, 322-480, 793-2945 or 2946; isolated polypeptides which comprise an amino acid sequence at least 80% homologous to seq id no: 517, 481-516, 518-792, 2947-4662 or 4663, nucleic acid constructs comprising same, transgenic cells and plants expressing same and methods of using same for increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.. .

06/30/16
20160186198 

Use of aldh7 for improved stress tolerance


The present invention relates to the field of plant molecular biology, more particularly to the regulation of genes that increase drought tolerance and yield. Provided herein are methods finding use in agriculture for increasing drought tolerance in dicot and monocot plants.

06/30/16
20160186197 

Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics


Provided are isolated polypeptides which are at least 80% homologous to seq id no: 474-643, 645-679, 681-755, 757-760, 4806-6390, 6395-6396, 6401-6895, 6897-7249, 7251-7685, 7687-7693, 7695-7700, 7702-7708, 7710-7796, 7798-7816, 7818, 7820-7837, 7839-7840, 7842-7861, 7863-8134, 8136-8163 or 8164, isolated polynucleotides which are at least 80% identical to seq id nos: 1-170, 172-267, 269-424, 426-473, 761-2486, 2489-2494, 2496-4803 or 4804, nucleic acid constructs comprising same, transgenic cells expressing same, transgenic plants expressing same and method of using same for increasing yield, harvest index, abiotic stress tolerance, growth rate, biomass, vigor, oil content, photosynthetic capacity, seed yield, fiber yield, fiber quality, fiber length, and/or nitrogen use efficiency of a plant.. .

06/30/16
20160186195 

Modification of soybean seed composition to enhance feed, food and other industrial applications of soybean products


polynucleotide sequences encoding diacylglycerol acyltransferases are used in combination with other coding sequence to modify the composition of soybean seed. The modified seed can be used to enhance feed, food and other industrial applications of soybean products..

06/30/16
20160186158 

Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis


Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise polypeptides comprising leishmania antigens as well as polynucleotides encoding such polypeptides..

06/30/16
20160186153 

B-1,3-glucanase, polynucleotide, recombinant vector, transformant, production b-1,3- glucanase, enzyme preparation, and production paramylon having reduced molecular weight


A β-1,3-glucanase that exhibits decomposition activity with respect to paramylon derived from the genus euglena. The β-1,3-glucanase is derived from the genus euglena and exhibits the properties indicated below: (1) effect: hydrolyzing the β-1,3-bond of β-1,3-glucan; and (2) substrate specificity: decomposing at least paramylon.

06/30/16
20160185834 

Protein engineered systems for delivery of molecules


Provided are compositions and methods for efficient delivery of polynucleotides and/or small molecules to or into cells. The compositions comprises a peptide which as an excess positive charge and self assembles into homopentamers.

06/30/16
20160185830 

Axmi440 toxin gene and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.

06/30/16
20160184420 

Novel compositions and methods


The present invention is directed to a polypeptide which comprises: (i) an rv1753c protein sequence; (ii) a variant of an rv1753c protein sequence; or (iii) an immunogenic fragment of an rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis..

06/30/16
20160184405 

Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy


The present invention provide purified flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.. .

06/30/16
20160184399 

Combined pharmaceutical composition


The present disclosure relates to a combined pharmaceutical composition, adapted for simultaneous, separate, or sequential administration for treating cancer in a subject comprising (a) a conjugate comprising (i) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and ii) a polypeptide comprising the amino acid sequence of the sushi domain of il-15ra or derivatives thereof; a polynucleotide coding therefore, or a vector comprising such a polynucleotide; and (b) an antibody antagonizing an immune pathway implicated in the inhibition of t cell activation, or a fragment thereof, a polynucleotide coding therefore, or a vector comprising such a polynucleotide.. .

06/30/16
20160184397 

Pharmaceutical composition for the treatment and/or prevention of disease involving abnormal accumulation of amyloid beta protein


Disclosed is a pharmaceutical composition for the treatment and/or prevention of a disease involving abnormal accumulation of amyloid β protein comprising ilei, or a vector into which a polynucleotide encoding ilei is inserted; a method for screening a compound for the treatment and/or prevention of a disease involving abnormal accumulation of amyloid β protein; and a method for treating and/or preventing a disease involving abnormal accumulation of amyloid β protein.. .

06/30/16
20160183561 

Polypeptides having a-l-galactosidase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having α-l-galactosidase activity, catalytic domains and poly-nucleotides encoding the polypeptides andcatalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains.

06/23/16
20160177398 

Dna methylation biomarkers for bladder cancer


A method for the prediction, prognosis and/or diagnosis of bladder cancer or bladder cancer recurrence in a subject, the method includes: providing a test sample from the subject; measuring dna methylation levels of at least a portion of two or more polynucleotides selected from the group consisting of hoxa9, soxi, npy, irak3, l1-met, and z02 in the test sample; calculating a risk score based on the measured dna methylation levels, comparing the calculated risk score to a cut-off value derived from a reference dna methylation profile based on dna methylation levels of the one or more biomarkers derived from a control group, members of which had bladder cancer; and based on the comparison calculated risk score to the cut-off value, determining at least one of: (1) whether bladder cancer has recurred; (2) whether there is likelihood that the bladder cancer will recur; and (3) whether the patient has bladder cancer.. .

06/23/16
20160177395 

Biomarkers for the prediction of renal injury


The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucelotides and proteins, and to kits utilizing same.. .

06/23/16
20160177343 

Polypeptides having glucoamylase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..

06/23/16
20160177336 

Expression tools for multiprotein applications


Polynucleotides for multigene applications comprising a novel functional arrangement, as well as vectors, host cells, and recombinant animals comprising the polynucleotides are described. Methods for generating multigene expression cassettes, methods for producing multiprotein complexes in vitro and in vivo, and methods for producing a vaccine are also disclosed.

06/23/16
20160177333 

Pesticidal genes and methods of use


Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the polypeptides, dna constructs and vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the polypeptides.

06/23/16
20160177332 

Axmi281 toxin gene and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.

06/23/16
20160177329 

Method of inhibiting sprouting in plant tissues


The present invention relates to a method for inhibiting sprouting, particularly pre-harvest sprouting, in plant seeds, by introducing a polynucleotide encoding a fca protein into the plant.. .

06/23/16
20160177308 

Therapeutic polynucleotides, compositions, and methods


This disclosure describes, in one aspect, a composition that generally includes an xna molecule comprising at least six nucleotides, in an amount effective to improve at least one indicator of myocyte function and a pharmaceutically acceptable carrier. In another aspect, this disclosure describes a method of treating cardiac disease.

06/23/16
20160177282 

Polypeptides having cellobiohydrolase i activity and polynucleotides encoding same


The present invention relates to polypeptides having cellobiohydrolase i activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides..

06/23/16
20160177280 

Alpha-amylase variants and polynucleotides encoding same


The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..

06/23/16
20160176963 

Antibodies to tigit


The present invention provides antibodies, or antigen binding fragments thereof, that bind to human tigit (t cell immunoreceptor with ig and itim domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the pd-1/pd-l1 interaction.

06/23/16
20160176936 

Mps peptides and use thereof


This disclosure provides an isolated polypeptide comprising no more than 35 amino acids, wherein the amino acid sequence comprises, or alternatively consists essentially of, or alternatively consisting of xxxrysyxxsyx (seq id no: 1) and equivalents thereof, wherein x is a basic amino acid and y is a hydrophobic amino acid. Polynucleotides encoding the polypeptides and antibodies that bind to the polypeptides are also provided.

06/23/16
20160175424 

Haemophilus influenzae type iv pili


The invention described herein relates to a haemophilus influenzae (h. Influenzae) regulon encoding type iv pili.

06/23/16
20160175406 

Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders


The present invention relates to methods and materials useful for systemically delivering polynucleotides across the blood brain barrier using adeno-associated virus as a vector. For example, the present invention relates to methods and materials useful for systemically delivering α-n-acetylglucosamidinase polynucleotides to the central and peripheral nervous systems, as well as the somatic system.

06/23/16
20160175370 

Targeting of herpes simplex virus to specific receptors


The invention relates to engineered herpes simplex virus (hsv) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such hsv particles are provided.

06/23/16
20160174589 

Polypeptides having beta-1,3-galactanase activity and polynucleotides encoding same


The present invention relates to polypeptides having beta-1,3-galactanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..

06/16/16
20160169875 

Nucleic acid sensor for melamine analysis, device for melamine analysis, and melamine analysis


The present invention is to provide a new sensor for melamine detection. The nucleic acid sensor for melamine analysis of the present invention includes a polynucleotide (x1) that includes a catalytic nucleic acid molecule (d) that activates a catalytic function and a binding nucleic acid molecule (a) that binds to melamine.
Nec Solution Innovators, Ltd.


06/16/16
20160168629 

Self-assembled single molecule arrays and uses thereof


The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations.
Callida Genomics, Inc.


06/16/16
20160168611 

Methods and synthesizing nucleic acids


The invention provides improved methods for synthesizing polynucleotides, such as dna and rna, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.
Molecular Assemblies, Inc.


06/16/16
20160168609 

Enhanced cellulose degradation


The present disclosure provides compositions and methods related to the degradation of cellulose and cellulose-containing materials. Cdh-heme domain polypeptides and gh61 polypeptides and related polynucleotides and compositions are provided herein.
The Regents Of The University Of California


06/16/16
20160168600 

3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase


Provided herein are recombinant yeast cells having an active 3-hydroxypropionic acid (3-hp) pathway and further comprising a heterologous polynucleotide encoding an aspartate 1-decarboxylase (adc) of the class insecta, bivalvia, branchioporia, gastropoda, or leptocardii. Also described are methods of using the recombinant yeast cells to produce 3-hp and acrylic acid..
Novozymes A/s


06/16/16
20160168587 

Methods and compositions for plant pest control


The present invention comprises methods and compositions for controlling nematode parasitism in host plant. The present invention comprises novel polynucleotides and polypeptides encoded by such polynucleotides comprising one or more nucleic acid sequences disclosed herein having a nucleotide sequence comprising any one of seq id no: 1-142 or 161, a fragment or variant thereof, or a complement thereof, or a polypeptide sequence comprising any one of seq id no: 143-160, a fragment or variant thereof..
The Curators Of The University Of Missouri


06/16/16
20160168586 

Corn plant event mon87460 and compositions and methods for detection thereof


The present invention provides a transgenic corn event mon87460, and cells, seeds, and plants comprising dna diagnostic for the corn event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for mon87460 in a sample, methods for detecting the presence of mon87460 event polynucleotides in a sample, and probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of mon87460 in a sample.
Monsanto Technology Llc


06/16/16
20160168574 

Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an insulin gene (ins), in particular, by targeting natural antisense polynucleotides of an insulin gene (ins). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of insulin gene (ins)..
Curna, Inc.


06/16/16
20160168568 

Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq)


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an adiponectin (adipoq), in particular, by targeting natural antisense polynucleotides of an adiponectin (adipoq). The invention also relates to the identification of these antisaese oligonucleotides and their use in treating diseases and disorders associated with the expression of adiponectins (adipoq)s..
Curna, Inc.


06/16/16
20160168557 

Modified beta-lactamases and methods and uses related thereto


Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.. .

06/16/16
20160168552 

Cellulases, nucleic acids encoding them and methods for making and using them


This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or β-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides.
Bp Corporation North America Inc.


06/16/16
20160168551 

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novoyzmes A/s


06/16/16
20160168547 

Polypeptides having lipase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
Novozymes A/s


06/16/16
20160168545 

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds


The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. .
Codexis, Inc.


06/16/16
20160168264 

Antibodies directed to her-3 and uses thereof


The present invention relates to binding proteins that bind to her-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided.
Amgen, Inc.


06/16/16
20160168263 

Certain improved human bispecific egfrviii antibody engaging molecules


We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human egfrviii mutant protein on its surface, and a second arm that specifically engages t cell activation ligand cd3. The polynucleotide is codon optimized for expression in cho cells.
The Government Of The U.s. As Represented By The Secretary Of Health




Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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