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Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS



Date/App# patent app List of recent Polynucleotide-related patents
07/23/15
20150205914 
 System and methods for detecting genetic variation patent thumbnailSystem and methods for detecting genetic variation
The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences.
Counsyl, Inc.


07/23/15
20150203926 
 Primer set for detecting bovine leukemia virus and use thereof patent thumbnailPrimer set for detecting bovine leukemia virus and use thereof
A forward primer of a primer set in accordance with the present invention for detecting blv is a mixture of (1) a first primer consisting of a polynucleotide including 15 or more successive bases including the 16th c in the base sequence of seq id no: 1 and (2) a second primer consisting of a plurality of kinds of polynucleotides including at least the first to 15th bases in the base sequence of seq id no: 2. Two or more of m, n, y, k, and d which are included in the second primer are each a degenerate base which specifies two or more kinds of bases, and the second primer includes at least 10 kinds of polynucleotides including at least the first to 15th bases in the base sequences of seq id nos: 3 to 12..
Riken Genesis Co., Ltd.


07/23/15
20150203911 
 Method for sequencing a polynucleotide template patent thumbnailMethod for sequencing a polynucleotide template
The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for sequence determination may or may not be complementary to each other..
Illumina Cambridge Limited


07/23/15
20150203910 
 Method for sequencing a polynucelotide template patent thumbnailMethod for sequencing a polynucelotide template
The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.. .
Illumina Cambridge Limited


07/23/15
20150203867 
 Compositions and methods for controlling leptinotarsa patent thumbnailCompositions and methods for controlling leptinotarsa
Disclosed herein are methods of controlling insect pests, in particular leptinotarsa spp. Which infest crop plants, and methods of providing plants resistant to such pests.
Monsanto Technology Llc


07/23/15
20150203865 
 Rnas from pathogens inhibit plant immunity patent thumbnailRnas from pathogens inhibit plant immunity
The present invention relates to pathogen-resistant plants comprising a heterologous expression cassette, the expression cassette comprising a promoter operably linked to a polynucleotide that is complementary to, or mediates destruction, of a plant immunity suppressing srna of a pathogen, wherein the plant is less susceptible to the pathogen compared to a control plant lacking the expression cassette. Methods of making and cultivating pathogen-resistant plants are also provided..
The Regents Of The University Of California


07/23/15
20150203862 
 Novel glycosyltransferase gene and use thereof patent thumbnailNovel glycosyltransferase gene and use thereof
A polynucleotide is provided that encodes a protein having activity that transfers a sugar to the hydroxyl group at the 4′-position of a flavone. The polynucleotide is selected from the group consisting of: (a) a polynucleotide composed of the base sequence of seq id no: 1; (b) a polynucleotide that hybridizes under stringent conditions with a polynucleotide composed of a base sequence complementary to the base sequence of seq id no: 1, and encodes a protein having activity that transfers a sugar to the hydroxyl group at the 4′-position of a flavone; (c) a polynucleotide encoding a protein composed of the amino acid sequence of seq id no: 2; and, (d) a polynucleotide encoding a protein composed of an amino acid sequence in which one or a plurality of amino acids have been deleted, substituted, inserted and/or added in the amino acid sequence of seq id no: 2, and having activity that transfers a sugar to the hydroxyl group at the 4′-position of a flavone..
Suntory Holdings Limited


07/23/15
20150203857 
 Increased protein expression in plants patent thumbnailIncreased protein expression in plants
This disclosure concerns synthetic polynucleotides encoding a polypeptide of interest that are particularly well-suited for expression in target plants.. .
Dow Agrosciences Llc


07/23/15
20150203850 
 Methods of treatment using tlr7 and/or tlr9 inhibitors patent thumbnailMethods of treatment using tlr7 and/or tlr9 inhibitors
The application relates to compositions and methods of regulating an immune response comprising inhibitors of tlr7 and/or tlr9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of tlr7 and/or tlr9..
Dynavax Technologies Corporation


07/23/15
20150203833 
 Aspergillus containing beta-glucosidase, beta-glucosidases and nucleic acids encoding the same patent thumbnailAspergillus containing beta-glucosidase, beta-glucosidases and nucleic acids encoding the same
A novel microorganism is provided named aspergillus saccharolyticus. Further, beta-glucosidase enzymes encoded by said microorganism are provided, and the use thereof in the degradation of lignocellulosic material.
Clean-vantage Llc


07/23/15
20150203831 

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


Provided are isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules..
Novozymes A/s


07/23/15
20150203817 

Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells


A method of expanding tcralpha deficient t-cells by expressing ptalpha or functional variants thereof into said cells, thereby restoring a functional cd3 complex. This method is particularly useful to enhance the efficiency of immunotherapy using primary t-cells from donors.
Cellectis


07/23/15
20150203576 

Variants of igg fc with limited amine groups


Lysine-depleted variants of fragment crystallizable (fc) regions of immunoglobulins are disclosed. Also disclosed are fusion proteins comprised of n-terminal targeting or active peptide domains fused with such lysine-depleted variant igg-fc domains.

07/23/15
20150203558 

Long-acting polypeptides and methods of producing same


A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (ctp) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed..
Opko Biologics Ltd.


07/23/15
20150203439 

Aminoalcohol lipidoids and uses thereof


Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided.
Massachusetts Institute Of Technology


07/23/15
20150202298 

Compositions for targeted delivery of sirna


The present invention is directed compositions for targeted delivery of rna interference (rnai) polynucleotides to hepatocytes in vivo. Targeted rnai polynucleotides are administered together with co-targeted delivery polymers.
Arrowhead Madison Inc.


07/16/15
20150198533 

Lucigen yellow (lucy), a yellow fluorescent protein


Described herein are isolated polynucleotides that encode a fluorescent protein which is at least 80% sequence identical to a protein selected from the group consisting of seq. Id.
Lucigen Corporation


07/16/15
20150197799 

Polynucleotide modification on solid support


The present disclosure relates to the field of molecular biology and more specifically to methods for capturing and amplifying target polynucleotides on a solid surface.. .
Illumina Cambridge Limited


07/16/15
20150197798 

Amplicon preparation and sequencing on solid supports


The present disclosure relates to the field of molecular biology and more specifically to methods for capturing, amplifying and sequencing target polynucleotides on a solid surface.. .
Illumina, Inc.


07/16/15
20150197796 

Ssb method


The invention relates to a method of characterising a target polynucleotide using a single-stranded binding protein (ssb). The ssb is either an ssb comprising a carboxy-terminal (c-terminal) region which does not have a net negative charge or a modified ssb comprising one or more modifications in its c-terminal region which decreases the net negative charge of the c-terminal region..
Oxford Nanopore Technologies Limited


07/16/15
20150197789 

End modification to prevent over-representation of fragments


The invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides and also the use of the 5′ and 3′ modified library of templates in methods of solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends, wherein over-representation of “end” sequences of the primary polynucleotide molecules from whence the 5′ and 3′ modified library is generated is greatly reduced or prevented..
Illumina Cambridge Limited


07/16/15
20150197786 

Method for attaching a counter sequence to a nucleic acid sample


Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules..
Population Genetics Technologies Ltd.


07/16/15
20150197768 

Plant transcription factors, promoters and uses thereof


polynucleotide molecules encoding transcription factors, promoter elements, binding partners and methods of use in increasing drought tolerance, yield, and abiotic stress tolerance are disclosed. Erf transcription factors and cor410b promoter sequences are disclosed..
Pioneer Hi Bred International Inc.


07/16/15
20150197763 

Soy nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement


Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
Monsanto Technology Llc


07/16/15
20150197750 

Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap


The present invention relates to antisense oligonucleosides that modulate the expression of and/or function of ‘iq motif containing gtpase activating protein’ (iqgap), in particular, by targeting natural antisense polynucleotides of ‘iq motif containing gtpase activating protein’ (iqgap). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of iqgap..
Curna, Inc.


07/16/15
20150197737 

Polypeptides having xylanase activity and polynucleotides thereof


The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
Novozymes, Inc.


07/16/15
20150197731 

Ketoreductase polypeptides for the production of azetidinone


The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds..
Codexis, Inc.


07/16/15
20150197567 

Antibodies to il-6 and use thereof


The present invention is directed to antibodies and fragments thereof having binding specificity for il-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the vii, vl and cdr polypeptides described herein, and the polynucleotides encoding them.
Alderbio Holdings Llc


07/16/15
20150197566 

Polynucleotides encoding antagonists of il-17a, il-17f, and il-23p19


The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of il-17a, il-17f, and il-23. Antagonists include antibodies and antibody fragments that bind il-23 and that bind il-17a or il-17f, such as antibodies that are cross-reactive for il-17a and il-17f.
Zymogenetics, Inc.


07/16/15
20150196629 

Immunogenic compositions of staphylococcus epidermidis polypeptide antigens


The present invention relates to immunogenic compositions, comprising polypeptides isolated from staphylococcus epidermidis. The invention also relates to polynucleotides encoding staphylococcus epidermidis polypeptides and their use in immunogenic compositions.
Wyeth Llc


07/09/15
20150191743 

Cloning and use of the ms9 gene from maize


Nucleotide sequences and amino acid sequences may be useful in methods mediating male fertility in plants, particularly maize, rice, or sorghum. Wild-type and mutant forms are useful for various purposes.
Pioneer Hi Bred International Inc


07/09/15
20150191740 

Polynucleotides and polypeptides involved in plant fiber development and methods of using same


Isolated polynucleotides are provided. Each of the isolated polynucleotides comprise a nucleic acid sequence encoding a polypeptide having an amino acid sequence at least 80% homologous to seq id no: 121, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 122, 123, 124, 125, 126, 95 or 96, wherein the polypeptide is capable of regulating cotton fiber development.
Evogene Ltd.


07/09/15
20150191739 

Rice nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement


Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
Monsanto Technology Llc


07/09/15
20150191736 

Use of clostridial methyltransferases for generating novel strains


This invention provides isolated polynucleotides encoding dna type i methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid dna into clostridial hosts.. .
Coskata, Inc.


07/09/15
20150191721 

Expression of maize codon optimized proteins in pseudomonas fluorescens


Compositions and methods for improving expression of a recombinant protein or polypeptide of interest in a host cell are provided. Compositions comprising a polynucleotide coding sequence for a btbooster are provided using a plant optimized system.
Dow Agrosciences Llc


07/09/15
20150191720 

High throughput discovery of new genes from complex mixtures of environmental microbes


Compositions and methods for isolating new variants of known gene sequences are provided. The methods find use in identifying variants, particularly homologs, in complex mixtures.
Agbiome, Inc.


07/09/15
20150191719 

Methods for nucleic acid assembly and high throughput sequencing


Methods and apparatus of some aspects of the invention relate to the synthesis of high fidelity polynucleotides. In particular, aspects of the invention relate to concurrent enzymatic removal of amplification sequences and ligation of processed oligonucleotides into nucleic acid assemblies.
Gen9, Inc.


07/09/15
20150191709 

Modified helicases


The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides..
Oxford Nanopore Technologies Limited


07/09/15
20150191516 

Ly6k epitope peptides for th1 cells and vaccines containing the same


Isolated ly6k-derived epitope peptides having th1 cell inducibility are disclosed herein. Such peptides can be recognized by mhc class ii molecules and induce th1 cells.
Oncotherapy Science, Inc.


07/09/15
20150191515 

Compositions and methods for modulating biomass productivity


The disclosure generally relates to methods and materials for modulating cell productivity. In particular, the present disclosure provides polynucleotides encoding transcription factor proteins that when overexpressed in microrganisms result in increased in productivity, such as increased biomass productivity.
Synthetic Genomics, Inc.


07/09/15
20150190499 

Bovine influenza c virus compositions


An influenza c virus has been isolated from a bovine species. Influenza c virus polynucleotides and polypeptides have also been identified.
Zoetis Llc


07/09/15
20150190496 

Vaccine and methods to reduce campylobacter infection


Vaccine vectors and methods for enhancing resistance to campylobacter infection or for enhancing the immune response to campylobacter are provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from seq id no: 7-9 or a fragment thereof.
The Board Of Trustees Of The University Of Arkansas


07/09/15
20150190490 

Cdca1 epitope peptides for th1 cells and vaccines containing the same


Isolated cdca1-derived epitope peptides having th1 cell inducibility are disclosed herein. Such peptides can be recognized by mhc class ii molecules and induce th1 cells.
Oncotherapy Science, Inc.


07/09/15
20150190489 

Kif20a epitope peptides for th1 cells and vaccines containing the same


Isolated kif20a-derived epitope peptides having th1 cell inducibility are disclosed herein. Such peptides can be recognized by mhc class ii molecules and induce th1 cells.
Oncotherapy Science. Inc.


07/02/15
20150184230 

Detection of bacteria belonging to the genus campylobacter by targeting cytolethal distending toxin


An objective of the present invention is to provide the cytolethal distending toxin (cdt) of c. Hyointestinalis and polynucleotides encoding it, and novel methods for detection of c.
Osaka Prefecture University Public Corporation


07/02/15
20150184215 

Development of the soluble recombinant crm197 production by e. coli


A method for recombinant production of a crm197 protein includes culturing a recombinant escherichia coli cell to produce said crm197 protein, and isolating said crm197 protein. The recombinant escherichia coli cell includes an expression vector, which contains a nucleic acid molecule that encodes a fusion protein that includes an e.
Development Center For Biotechnology


07/02/15
20150184199 

Methods for genomic integration


Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more integration polynucleotides comprising an exogenous nucleic acid to be integrated into a genomic target site, a nuclease capable of causing a break at the genomic target site, and a linear nucleic acid capable of homologous recombination with itself or with one or more additional linear nucleic acids contacted with the population of cells, whereupon said homologous recombination results in formation of a circular extrachromosomal nucleic acid comprising a coding sequence for a selectable marker.
Amyris, Inc.


07/02/15
20150184191 

Yield and stress tolerance in transgenic plants iv


Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered c/n sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant..
Monsanto Technology Llc


07/02/15
20150184188 

Plants with enhanced size and growth rate


Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention regulate transcription in these plants and have been shown to confer at least one regulatory activity that results in increased size, biomass, growth rate, and/or yield as compared to a control plant..
Mendel Biotechnology, Inc.


07/02/15
20150184174 

Soybean adf1 promoter and its use in constitutive expression of transgenic genes in plants


The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean actin depolymerizing factor gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E.i. Du Pont De Nemours And Company


07/02/15
20150184173 

Compositions and methods comprising sequences having meganuclease activity


Compositions and methods comprising polynucleotides and polypeptides having meganuclease activity are provided. Further provided are nucleic acid constructs, yeast, plants, plant cells, explants, seeds and grain having the meganuclease sequences.
Pioneer Hi Bred International Inc.


07/02/15
20150184169 

Sulfonylurea-responsive repressor proteins


Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound.
Pioneer Hi-bred International Inc


07/02/15
20150184161 

Eml4-alk fusion gene


The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene.
Curegene K.k.


07/02/15
20150184158 

Translocation and mutant ros kinase in human non-small cell lung carcinoma


In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of sodium-dependent phosphate transporter isoform napi-3b protein (slc34a2) with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The slc34a2-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
Cell Signaling Technology, Inc.


07/02/15
20150184143 

Cyaa-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses


The invention relates to a chimeric protein comprising or consisting of from n-terminal to c-terminal, (a) a n-terminal part of a bordetella cyaa protein (b) a heterologous polypeptide, and (c) a c-terminal part of a bordetella cyaa protein. The invention also relates to a polynucleotide encoding a deleted version of a bordetella cyaa, as well as a polynucleotide encoding this chimeric protein.
Genticel


07/02/15
20150183856 

Novel monoclonal antibody binding specifically to dll4 and use thereof


The present invention relates to a novel monoclonal antibody that binds specifically to delta-like ligand (dll4), and more particularly to a monoclonal antibody that binds specifically to human delta-like ligand 4 to effectively inhibit the interaction between delta-like ligand 4 and notch receptor, a polynucleotide encoding the monoclonal antibody, an expression vector comprising the polynucleotide, a transformant comprising the expression vector, a method for preparing the monoclonal antibody, a pharmaceutical composition for preventing or treating cancer comprising the monoclonal antibody, a composition for diagnosing cancer comprising the monoclonal antibody, a method for diagnosing cancer using the monoclonal antibody, and a pharmaceutical composition for preventing or treating autoimmune disease comprising the monoclonal antibody.. .
Hanwha Chemical Corporattion


07/02/15
20150183853 

Methods and compositions for generation of germline human antibody genes


The present invention relates to a method for in vitro producing polynucleotides encoding human germline antibody v-regions. Also disclosed is a library of human germline antibody v-region genes..
Integrigen, Inc.


07/02/15
20150183842 

Cardiac arrhythmia treatment methods


Disclosed are methods of preventing or treating cardiac arrhythmia. In one embodiment, the methods include administering to an amount of at least one polynucleotide that modulates an electrical property of the heart.
The Johns Hopkins University


07/02/15
20150183838 

Biomass productivity regulator


The disclosure generally relates to methods and materials for modulating cell productivity. In particular, the present disclosure provides polynucleotides and polypeptides that when overexpressed in microorganisms result in increased in productivity, such as increased biomass productivity.
Synthetic Genomics, Inc.


07/02/15
20150181873 

Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large subunit proteins, and methods of use


Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Basf Aktiengesellschaft


06/25/15
20150176057 

Methods and sequential amplification reactions


The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample..
Cepheid


06/25/15
20150176040 

Production of fatty alcohols from engineered microorganisms


Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a β-ketoacyl acyl carrier protein synthase..
Codexis, Inc.


06/25/15
20150176022 

Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large subunit proteins, and methods of use


Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Basf Aktiengesellschaft


06/25/15
20150176021 

Use of cad genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant


Provided are methods of increasing nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide at least 80% identical to seq id no: 2560, 2557, 184, 238, 188, 154-156, 158-161, 163-183, 185-187, 189-197, 200-237, 239-264, 266-269, 1351, 1365-1425, 1429-1457, 1459, 1461-1730, 1735, 1739-2397, 2533-2541, 2544-2556, 2558, 2559, 2561-2562 or 2563. Also provided are isolated polynucleotides and polypeptides which can be used to increase nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant of a plant..
Evogene Ltd.


06/25/15
20150175990 

Polypeptides having endoglucanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


06/25/15
20150175989 

Polypeptides having cellobiohydrolase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


06/25/15
20150175981 

Selection in fungi


The present invention relates to methods for constructing a recombinant fungal host cell comprising one or more copies of a polynucleotide construct integrated in its genome, said method comprising transforming a fungal host cell with an integrative polynucleotide construct comprising a first polynucleotide encoding a selectable marker, wherein the first polynucleotide, a 5′ untranslated region thereof and/or a riboswitch operably linked therewith comprises a spliceosomal intron which has 5 nucleotides or less between its branch site and its acceptor site; and a second polynucleotide encoding a polypeptide of interest; as well as suitable polynucleotide constructs, resulting fungal host cells and methods of manufacture.. .
Novozymes A/s Of Krogshoejvej 36


06/25/15
20150175980 

Novel cell wall deconstruction enzymes of scytalidium thermophilum, myriococcum thermophilum, and aureobasidium pullulans, and uses thereof


The present invention relates to novel polypeptides and enzymes (e.g., thermostable proteins and enzymes) having activities relating to biomass processing and/or degradation (e.g., cell wall deconstruction), as well as polynucleotides, vectors, cells, compositions and tools relating to same, or functional variants thereof. More particularly, the present invention relates to secreted enzymes that may be isolated from the fungi, scytalidium thermophilum strain cbs 625.91, myriococcum thermophilum strain cbs 389.93, and aureobasidium pullulans strain atcc 62921.
Concordia University


06/25/15
20150175688 

Production cell line enhancers


The present invention relates to discovery of the ectopic expression of edem2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the cho cell, containing recombinant polynucleotides encoding edem2.
Regeneron Pharmaceuticals, Inc.


06/25/15
20150175671 

Oil globule protein and uses thereof


An isolated novel oil globule protein encoded by a polynucleotide sequence is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a polynucleotide encoding a protein which at least partially comprises the amino acid sequence of the novel oil globule protein is also provided.
Yeda Research And Development Co. Ltd.


06/25/15
20150175667 

Targeted gene delivery for dendritic cell vaccination


Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (dc). The virus envelope comprises a dc-sign specific targeting molecule.
California Institute Of Technology


06/25/15
20150175662 

Novel peptides and use thereof


The present invention relates to novel peptides and use thereof and more specifically is directed to a peptide with anti-inflammatory effect, a polynucleotide encoding the peptide, a pharmaceutical composition comprising the peptide or polynucleotide for preventing or treating inflammatory diseases, an anti-inflammatory drug, an over-the-counter (otc) drug composition comprising the peptide for preventing or ameliorating inflammation, a health food composition for alleviating or ameliorating inflammation, a cosmetic composition for preventing or ameliorating inflammation, a method for treating inflammatory diseases, comprising administrating the pharmaceutical composition to the subject suspected of having inflammatory disease, a method for preparing a mimetic of the peptide and a method for designing the same.. .
Samsung Life Public Welfare Foundation


06/25/15
20150174223 

Ube2t peptides and vaccines containing the same


Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the ube2t that elicit ctls are provided.
Onco Therapy Science, Inc.


06/18/15
20150167106 

Nucleic acid molecule that binds to influenza viruses and use thereof


(d) a polynucleotide that has a base sequence complementary to a polynucleotide hybridizing to any of the base sequences of the polynucleotide (a) under stringent conditions and binds to the influenza virus.. .

06/18/15
20150167092 

Fret-based analytes detection and related methods and systems


Fret-based analytes detection and related methods and systems are described where a pair of fret labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the förster distance of the fret chromophores presented on the fret labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of fret labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring fret signals from at least one fret chromophore.. .
California Institute Of Technology


06/18/15
20150167030 

Recombinant cellulosome complex and uses thereof


The present invention relates to a polynucleotide encoding a recombinant scaffolding polypeptide comprising at least a signal peptide, a cellulose binding domain, two cohesin domains and an s-layer homology domain, wherein said isolated polynucleotide preferably comprises all or an active part of the nucleotide sequence as set forth in seq id no:2. The present invention further relates to vectors comprising such polynucleotides, recombinant lactic acid bacteria, and method for degrading a cellulosic biomass using such recombinant lactic acid bacteria..
Carbios


06/18/15
20150167015 

Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics


Provided are isolated polynucleotides, polypeptides encoded thereby, nucleic acid constructs comprising same, plant cells and plants comprising same and methods of generating plants with increased yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency, wherein the polynucleotides encode polypeptides at least 80% identical to seq id no: 574-930, 6266-10549 or 10550, such as the polynucleotides set forth in seq id nos:1-573, and 931-6265.. .
Evogene Ltd.


06/18/15
20150167012 

Plant regulatory elements and uses thereof


The present invention provides novel dna molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and plant cells. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising the dna molecules operably linked to heterologous transcribable polynucleotides, along with methods of their use..
Monsanto Technology Llc


06/18/15
20150167011 

Soybean ccp1 promoter and its use in constitutive expression of transgenic genes in plants


The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean copper chaperone homolog gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E. I. Du Pont De Nemours And Company


06/18/15
20150167007 

Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of sialidase 4 (neu4), in particular, by targeting natural antisense polynucleotides of sialidase 4 (neu4). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of neu4..
Curna, Inc.


06/18/15
20150166994 

Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of nanog, in particular, by targeting natural antisense polynucleotides of nanog. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of nanog..
Curna, Inc.


06/18/15
20150166971 

Polypeptides having cellulase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


06/18/15
20150166652 

Bacterial host strain expressing recombinant dsbc and having reduced tsp activity


The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding dsbc and has reduced tsp protein activity compared to a wild-type cell.. .
Ucb Pharma, S.a.


06/18/15
20150166635 

Gpr88 mini-promoters


Isolated polynucleotides comprising a gpr88 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia


06/18/15
20150166616 

Modified polynucleotides for the production of cosmetic proteins and peptides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of cosmetic polynucleotides, cosmetic primary transcripts and cosmetic mmrna molecules.. .
Moderna Therapeutics, Inc.


06/18/15
20150166614 

Polynucleotides and polypeptides in plants


The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
Mendel Biotechnology, Inc.


06/18/15
20150166462 

Ionizable cationic lipids


Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids..
Shire Human Genetic Therapies. Inc.




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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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