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This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large…

Basf Aktiengesellschaft

Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large…

Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large…

Evogene

Use of cad genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant

Date/App# patent app List of recent Polynucleotide-related patents
06/25/15
20150176057
 Methods and  sequential amplification reactions patent thumbnailMethods and sequential amplification reactions
The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample..
Cepheid
06/25/15
20150176040
 Production of fatty alcohols from engineered microorganisms patent thumbnailProduction of fatty alcohols from engineered microorganisms
Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a β-ketoacyl acyl carrier protein synthase..
Codexis, Inc.
06/25/15
20150176022
 Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large subunit proteins, and methods of use patent thumbnailHerbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large subunit proteins, and methods of use
Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Basf Aktiengesellschaft
06/25/15
20150176021
 Use of cad genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant patent thumbnailUse of cad genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant
Provided are methods of increasing nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide at least 80% identical to seq id no: 2560, 2557, 184, 238, 188, 154-156, 158-161, 163-183, 185-187, 189-197, 200-237, 239-264, 266-269, 1351, 1365-1425, 1429-1457, 1459, 1461-1730, 1735, 1739-2397, 2533-2541, 2544-2556, 2558, 2559, 2561-2562 or 2563. Also provided are isolated polynucleotides and polypeptides which can be used to increase nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant of a plant..
Evogene Ltd.
06/25/15
20150175990
 Polypeptides having endoglucanase activity and polynucleotides encoding same patent thumbnailPolypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s
06/25/15
20150175989
 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same patent thumbnailPolypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.
06/25/15
20150175981
 Selection in fungi patent thumbnailSelection in fungi
The present invention relates to methods for constructing a recombinant fungal host cell comprising one or more copies of a polynucleotide construct integrated in its genome, said method comprising transforming a fungal host cell with an integrative polynucleotide construct comprising a first polynucleotide encoding a selectable marker, wherein the first polynucleotide, a 5′ untranslated region thereof and/or a riboswitch operably linked therewith comprises a spliceosomal intron which has 5 nucleotides or less between its branch site and its acceptor site; and a second polynucleotide encoding a polypeptide of interest; as well as suitable polynucleotide constructs, resulting fungal host cells and methods of manufacture.. .
Novozymes A/s Of Krogshoejvej 36
06/25/15
20150175980
 Novel cell wall deconstruction enzymes of scytalidium thermophilum, myriococcum thermophilum, and aureobasidium pullulans, and uses thereof patent thumbnailNovel cell wall deconstruction enzymes of scytalidium thermophilum, myriococcum thermophilum, and aureobasidium pullulans, and uses thereof
The present invention relates to novel polypeptides and enzymes (e.g., thermostable proteins and enzymes) having activities relating to biomass processing and/or degradation (e.g., cell wall deconstruction), as well as polynucleotides, vectors, cells, compositions and tools relating to same, or functional variants thereof. More particularly, the present invention relates to secreted enzymes that may be isolated from the fungi, scytalidium thermophilum strain cbs 625.91, myriococcum thermophilum strain cbs 389.93, and aureobasidium pullulans strain atcc 62921.
Concordia University
06/25/15
20150175688
 Production cell line enhancers patent thumbnailProduction cell line enhancers
The present invention relates to discovery of the ectopic expression of edem2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the cho cell, containing recombinant polynucleotides encoding edem2.
Regeneron Pharmaceuticals, Inc.
06/25/15
20150175671
 Oil globule protein and uses thereof patent thumbnailOil globule protein and uses thereof
An isolated novel oil globule protein encoded by a polynucleotide sequence is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a polynucleotide encoding a protein which at least partially comprises the amino acid sequence of the novel oil globule protein is also provided.
Yeda Research And Development Co. Ltd.
06/25/15
20150175667

Targeted gene delivery for dendritic cell vaccination


Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (dc). The virus envelope comprises a dc-sign specific targeting molecule.
California Institute Of Technology
06/25/15
20150175662

Novel peptides and use thereof


The present invention relates to novel peptides and use thereof and more specifically is directed to a peptide with anti-inflammatory effect, a polynucleotide encoding the peptide, a pharmaceutical composition comprising the peptide or polynucleotide for preventing or treating inflammatory diseases, an anti-inflammatory drug, an over-the-counter (otc) drug composition comprising the peptide for preventing or ameliorating inflammation, a health food composition for alleviating or ameliorating inflammation, a cosmetic composition for preventing or ameliorating inflammation, a method for treating inflammatory diseases, comprising administrating the pharmaceutical composition to the subject suspected of having inflammatory disease, a method for preparing a mimetic of the peptide and a method for designing the same.. .
Samsung Life Public Welfare Foundation
06/25/15
20150174223

Ube2t peptides and vaccines containing the same


Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the ube2t that elicit ctls are provided.
Onco Therapy Science, Inc.
06/18/15
20150167106

Nucleic acid molecule that binds to influenza viruses and use thereof


(d) a polynucleotide that has a base sequence complementary to a polynucleotide hybridizing to any of the base sequences of the polynucleotide (a) under stringent conditions and binds to the influenza virus.. .
06/18/15
20150167092

Fret-based analytes detection and related methods and systems


Fret-based analytes detection and related methods and systems are described where a pair of fret labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the förster distance of the fret chromophores presented on the fret labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of fret labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring fret signals from at least one fret chromophore.. .
California Institute Of Technology
06/18/15
20150167030

Recombinant cellulosome complex and uses thereof


The present invention relates to a polynucleotide encoding a recombinant scaffolding polypeptide comprising at least a signal peptide, a cellulose binding domain, two cohesin domains and an s-layer homology domain, wherein said isolated polynucleotide preferably comprises all or an active part of the nucleotide sequence as set forth in seq id no:2. The present invention further relates to vectors comprising such polynucleotides, recombinant lactic acid bacteria, and method for degrading a cellulosic biomass using such recombinant lactic acid bacteria..
Carbios
06/18/15
20150167015

Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics


Provided are isolated polynucleotides, polypeptides encoded thereby, nucleic acid constructs comprising same, plant cells and plants comprising same and methods of generating plants with increased yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency, wherein the polynucleotides encode polypeptides at least 80% identical to seq id no: 574-930, 6266-10549 or 10550, such as the polynucleotides set forth in seq id nos:1-573, and 931-6265.. .
Evogene Ltd.
06/18/15
20150167012

Plant regulatory elements and uses thereof


The present invention provides novel dna molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and plant cells. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising the dna molecules operably linked to heterologous transcribable polynucleotides, along with methods of their use..
Monsanto Technology Llc
06/18/15
20150167011

Soybean ccp1 promoter and its use in constitutive expression of transgenic genes in plants


The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean copper chaperone homolog gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E. I. Du Pont De Nemours And Company
06/18/15
20150167007

Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of sialidase 4 (neu4), in particular, by targeting natural antisense polynucleotides of sialidase 4 (neu4). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of neu4..
Curna, Inc.
06/18/15
20150166994

Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of nanog, in particular, by targeting natural antisense polynucleotides of nanog. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of nanog..
Curna, Inc.
06/18/15
20150166971

Polypeptides having cellulase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s
06/18/15
20150166652

Bacterial host strain expressing recombinant dsbc and having reduced tsp activity


The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding dsbc and has reduced tsp protein activity compared to a wild-type cell.. .
Ucb Pharma, S.a.
06/18/15
20150166635

Gpr88 mini-promoters


Isolated polynucleotides comprising a gpr88 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia
06/18/15
20150166616

Modified polynucleotides for the production of cosmetic proteins and peptides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of cosmetic polynucleotides, cosmetic primary transcripts and cosmetic mmrna molecules.. .
Moderna Therapeutics, Inc.
06/18/15
20150166614

Polynucleotides and polypeptides in plants


The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
Mendel Biotechnology, Inc.
06/18/15
20150166462

Ionizable cationic lipids


Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids..
Shire Human Genetic Therapies. Inc.
06/18/15
20150164987

Wnt signaling inhibitor comprising insulin-like growth factor-binding protein


Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of wnt signalling, comprising an insulin-like growth-factor-binding protein (igfbp), the protein being binding to a wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced wnt signalling, comprising the inhibitor of wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof..
National University Corporation Chiba University
06/18/15
20150164954

Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases


Disclosed herein are methods and compositions for inactivating tcr genes, using zinc finger nucleases (zfns) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding zfns, vectors comprising polynucleotides encoding zfns and cells comprising polynucleotides encoding zfns and/or cells comprising zfns are also provided.
Ospedale San Raffaele Srl
06/11/15
20150160160

Dual-pore device


Provided is a device comprising an upper chamber, a middle chamber and a lower chamber, wherein the upper chamber is in communication with the middle chamber through a first pore, and the middle chamber is in communication with the lower chamber through a second pore, wherein the first pore and second pore are about 1 nm to about 100 nm in diameter, and are about 10 nm to about 1000 nm apart from each other, and wherein each of the chambers comprises an electrode for connecting to a power supply. Methods of using the device are also provided, in particular for sequencing a polynucleotide..
The Regents Of The University Of California
06/11/15
20150159206

Methods for detection and typing of nucleic acids


Disclosed are methods and kits for identifying and characterizing polynucleotide sequences in a sample which may include a heterogeneous sample. Some of the methods and kits are directed to the identification and characterization of a virus in a sample, which may include hiv capable of cause aids or aids-like symptoms.
Luminex Corporation
06/11/15
20150159176

Engineered cleavage half-domains


Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence..
Sangamo Biosciences, Inc.
06/11/15
20150159166

Plant drought tolerance and nitrogen use efficiency by reducing plant sensitivity to ethylene


The present disclosure provides polynucleotides and related polypeptides which are used to modify ethylene sensitivity in plants. Ethylene insensitive transgenic maize plants produce higher grain yields in water deficient and low nitrogen environments than non-transgenic plants.
Pioneer Hi Bred International Inc
06/11/15
20150159162

Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of tumor suppressor genes, in particular, by targeting natural antisense polynucleotides of tumor suppressor genes. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of tumor suppressor genes..
Curna, Inc.
06/11/15
20150159157

Micrornas


The invention provides methods and compositions useful in target sequence suppression, target sequence validation and target sequence down regulation. The invention provides polynucleotide constructs useful for gene silencing or rna down regulation, as well as cells, plants and seeds comprising the polynucleotides.
The Rockefeller University
06/11/15
20150159009

Graft copolymers, their preparation and use in capillary electrophoresis


The invention relates to graft copolymers, their preparation, and compositions, such as electrophoresis separation media, containing the same; also to ultra-high molecular weight poly(n,n-dimethylacrylamide) (“poly(dma)”) polymers, their preparation, and compositions, such as electrophoresis separation media, containing the same; and more particularly to supports, such as capillaries, containing these polymers and methods for separating biomolecules, especially polynucleotides, using capillary electrophoresis. The graft copolymers can be prepared by, e.g., grafting polyacrylamide units onto a poly(dma) backbone.
Applied Biosystems, Llc
06/11/15
20150158928

Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy


The present invention provide purified flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.. .
Vegenics Pty Limited
06/11/15
20150157737

Polymers for functional particles


A method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer.
The Brigham And Women's Hospital, Inc.
06/11/15
20150157696

Composition and inhibiting tumor cell growth


Polynucleotides encoding a secreted mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided.
The University Of North Carolina
06/04/15
20150154351

System and classification of patients


System (100) for classifying a biological test sample, including a database (112) populated with reference expression data. The reference expression data includes expression levels of a plurality of molecules (polynucleotides or polypeptides), including a set of marker molecules, in a plurality of reference samples.
Signal Genetics Llc
06/04/15
20150153363

Markers of the male urogenital tract


Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides, encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention.
Mount Sinai Hospital
06/04/15
20150153358

Materials and methods for diagnosing and treating shellfish allergy


The disclosure provides materials and methods for diagnosing, treating and preventing shellfish allergic reactions, including allergic reactions to shrimp. The technology involves one or more shellfish-specific proteins selected from the group of myosin light chain, sarcoplasmic calcium-binding protein, hemocyanin, fatty acid binding protein, and troponin c, for example from shrimp, as well as encoding polynucleotides, vectors host cells, and specific binding partners for such proteins, e.g., antibodies.
Icahn School Of Medicine At Mount Sinai
06/04/15
20150152495

Compositions and methods for polynucleotide sequencing


Methods and compositions for characterizing a target polynucleotide, including, characterizing the sequence of the target polynucleotide, using the fractional translocation steps of the target polynucleotide's translocation through a pore.. .
Illumina, Inc.
06/04/15
20150152492

Hairpin loop double strand polynucleotide sequencing using transmembrane pores


The invention relates to a new method of sequencing a double stranded target polynucleotide. The two strands of the double stranded target polynucleotide are linked by a bridging moiety.
Oxford Nanopore Technologies Limited
06/04/15
20150152456

Polypeptides having glucuronyl esterase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having glucuronyl esterase activity, catalytic domains and polynucleotides encoding the polypeptides or catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains..
Novozymes A/s
06/04/15
20150152455

Polypeptides having berberine bridge enzyme like activity and polynucleotides encoding same


Provided are isolated polypeptides having berberine bridge enzyme like activity, catalytic domains, fad binding domains and polynucleotides encoding the polypeptides, catalytic domains or fad binding domains. The nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or fad binding domains are also provided..
Novozymes A/s
06/04/15
20150152453

Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans


The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-d-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-d-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-d-glucan synthase-activity or the use of such a polypeptide for producing β-glucans.
Wintershall Holding Gmbh
06/04/15
20150152443

Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids


The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (dhad)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said dhad-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more aft proteins or homologs thereof.
Gevo, Inc.
06/04/15
20150152440

Modified microorganisms and methods of co-producing butadiene with 1-propanol and/or 1,2-propanediol


The present disclosure generally relates to microorganisms that comprise one or more polynucleotides coding for enzymes in a pathway that catalyzes a conversion of a fermentable carbon source to butadiene and/or one or more polynucleotides coding for enzymes in a pathway that catalyzes a conversion of a fermentable carbon source to 1-propanol and/or 1,2-propanadiol. Also provided are methods of using the microorganisms to produce butadiene and co-products such 1-propanol and/or 1,2-propanediol..
Braskem S.a.
06/04/15
20150152437

Chromosomal landing pads and related uses


Provided herein are methods for stable integration and/or expression of one or more recombinant polynucleotides in a host cell. The recombinant polynucleotides are typically integrated into the host genome at some native chromosomal integration sites.
The Scripps Research Institute
06/04/15
20150152431

Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance


Provided are methods of increasing nitrogen use efficiency, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence at least 80% identical to seq id no: 387, 1-386, 388-469, 763-3704 and 3705; or an exogenous polynucleotide encoding a polypeptide at least 80% identical to seq id no: 602, 470-601, 603-762, 3706-5858, 5860-5910, 5912, 5914-5923, 5925-6046 or 6047. Also provided is an isolated polynucleotide comprising a nucleic acid sequence selected from the group consisting of seq id nos: 387, 1-386, 388-469, 763-3704 and 3705, which can be used to increase the nitrogen use efficiency, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality and/or abiotic stress tolerance of a plant..
Evogene Ltd.
06/04/15
20150152426

Treatment of par4 related diseases by inhibition of natural antisense transcript to par4


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of par4, in particular, by targeting natural antisense polynucleotides of par4. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of par4..
Curna, Inc.
06/04/15
20150152425

Treatment of methionine sulfoxide reductase a (msra) related diseases by inhibition of natural antisense transcript to msra


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of methionine sulfoxide reductase a (msra), in particular, by targeting natural antisense polynucleotides of methionine sulfoxide reductase a (msra). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of msra..
Curna, Inc.
06/04/15
20150152424

Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of pyrroline-5-carboxylate reductase 1 (pycr1), in particular, by targeting natural antisense polynucleotides of pyrroline-5-carboxylate reductase 1 (pycr1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of pycr1..
Curna, Inc.
06/04/15
20150152419

Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisense transcript to csf3


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of colony-stimulating factor 3 (csf3), in particular, by targeting natural antisense polynucleotides of colony-stimulating factor 3 (csf3). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of csf3..
Curna, Inc.
06/04/15
20150152417

Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity


The present invention relates to antisense oligonucleotides and/or compounds that modulate the expression of and/or function of filaggrin (flg), in particular, by targeting natural antisense polynucleotides of filaggrin (flg). The invention also relates to the identification of these antisense oligonucleotides and/or compounds and their use in treating diseases and disorders associated with the expression of flg..
Curna, Inc.
06/04/15
20150152397

Polypeptides having organophosphorous hydrolase activity


The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s
06/04/15
20150152394

Flavin-conjugated glucose dehydrogenase and polynucleotide encoding the same


The purpose of the invention is to provide flavin-conjugated glucose dehydrogenase having little variation in activity in the typical biosensor measurement temperature range (10-40° c.) and a method for measuring glucose using same. The present invention relates to flavin-conjugated glucose dehydrogenase having the following properties (1)-(3) and the like: (1) action: shows glucose dehydrogenase activity in the presence of an electron acceptor; (2) substrate specificity: the activity value is 10% or less relative to maltose, d-galactose, d-fructose, sorbitol, lactose, and sucrose when the activity value relative to d-glucose is taken to be 100%; and (3) temperature characteristics: the range of the activity value at 10-40° c.
Ikeda Food Research Co., Ltd.
06/04/15
20150152176

Antagonist antibodies against gdf-8


The disclosure provides novel molecules related to growth and differentiation factor-8 (gdf-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit gdf-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (als).
Wyeth Llc
06/04/15
20150152155

Long-acting polypeptides and methods of producing same


A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (ctp) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed..
Opko Biologics Ltd.
06/04/15
20150152146

Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement


Recombinant polynucleotides and recombinant polypeptides useful for improvement of plants are provided. The disclosed recombinant polynucleotides and recombinant polypeptides find use in production of transgenic plants to produce plants having improved properties..
Monsanto Technology Llc
06/04/15
20150150962

Chicken astrovirus responsible for runting stunting syndrome


The present invention includes isolated astroviruses capable of reproducing the full runting stunting syndrome (rss) disease spectrum in poultry, including a chicken astrovirus isolated from the gut of chickens (ckastv-gut), a cell culture chicken astrovirus ckastv-p5, and a chicken astrovirus isolated after back passage in chicken (ckastv-p5-ckp5), and infected cell lines, cell culture supernatants, polynucleotide sequences, vectors, polypeptides, compositions, and vaccines thereof. The present invention also includes diagnostic methods based on such isolated viruses and infected cell lines, cell culture supernatants, polynucleotide sequences, vectors, and polypeptides thereof, and methods of protecting poultry, including chickens, against rss by the administration of such isolated viruses and infected cell lines, cell culture supernatants, polynucleotide sequences, vectors, polypeptides, compositions, and vaccines thereof..
University Of Georgia Research Foundation, Inc.
06/04/15
20150150920

Use of mutant herpes simplex virus-2 for cancer therapy


The present invention is directed to the composition and use of a modified herpes simplex virus type 2 (hsv-2) as a medicament in the treatment of cancer. The modified hsv-2 has fusogenic activity, and comprises a modified/mutated icp10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase activity..
The University Of Houston System
05/28/15
20150150157

Prephenate dehydrogenases and arogenate dehydrogenases that are insensitive to effector feedback inhibition and methods of using the same


Prephenate dehydrogenases and arogenate dehydrogenase polynucleotide and polypeptide sequences are provided herein. These polypeptides are all insensitive to effector based feedback inhibition.
Wisconsin Alumni Research Foundation
05/28/15
20150148528

Chromatographic purification of polynucleotides with negatively charged particles


A method of purifying a sample that includes a polynucleotide includes the steps of (i) providing a packed chromatographic column having negatively charged porous particles, (ii) equilibrating the column to the conditions to which the polynucleotide in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the negatively charged porous particles within the packed chromatographic column, (iv) eluting the polynucleotide from the packed chromatographic column, where the polynucleotide is in a purer state and in the conditions to which the packed chromatographic column was equilibrated.. .
Agency For Science, Technology And Research
05/28/15
20150148293

Fibroblast growth factor mutants having improved functional half-life and methods of their use


Mutant fibroblast growth factor (fgf) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human fgf-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human fgf-1 with a tryptophan (based on the 140 amino acid numbering scheme of human fgf-1) are provided. Other amino acid mutations or substitutions may be combined.
Florida State University Research Foundation
05/28/15
20150148291

Long-acting polypeptides and methods of producing and administering same


A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed..
Opko Biologics Ltd.
05/28/15
20150148263

Methods for selecting and amplifying polynucleotides


The invention provides methods for controlling the density of different molecular species on the surface of a solid support. A first mixture of different molecular species is attached to a solid support under conditions to attach each species at a desired density, thereby producing a derivatized support having attached capture molecules.
Illumina, Inc.
05/28/15
20150148246

Surface anchored light chain bait antibody display system


The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host.
Merck Sharp & Dohme Corp.
05/28/15
20150147813

Methods and materials for increasing potency of cells


Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage..
University Of Central Florida Research Foundation, Inc.
05/28/15
20150147755

Probe based nucleic acid detection


The invention provides a method for detecting a target nucleotide sequence by tagging the nucleotide sequence with a nucleotide tag, providing a probe oligonucleotide with a melting temperature tm1, comprising a regulatory sequence and a nucleotide tag recognition sequence; incorporating the probe oligonucleotide into the tagged polynucleotide in a polynucleotide amplification reaction, providing a regulatory oligonucleotide with a melting temperature tm2, comprising a sequence segment that is at least partially complementary to the regulatory sequence, amplifying the tagged target nucleic acid sequence in a pcr amplification reaction using the probe oligonucleotide as a primer, and detecting the amplification product; wherein tm1 and tm2 are higher than the annealing temperature associated with the polynucleotide amplification reaction.. .
Fluidigm Corporation
05/28/15
20150147365

Oral preparation


The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host.
Dsm Ip Assets B.v.
05/28/15
20150147318

Caninized anti-ngf antibodies and methods thereof


The invention provides novel caninized anti-ngf antibodies (such as caninized anti-ngf antagonist antibodies and antigen binding proteins), and polynucleotides encoding the same. The invention further provides use of said antibodies or antigen binding proteins and/or nucleotides in the treatment and/or prevention of ngf related disorders, particularly pain..
Zoetis Llc
05/28/15
20150147302

Therapeutically useful molecules


A t cell receptor molecule (tcr) containing an alpha chain portion and a beta chain portion wherein the alpha chain portion contains three complementarity determining regions (cdrs): cdr1α: ssysps cdr2α: ytsaatl cdr3α: vvspf-sgggadglt or comprising or consisting of sppsgggadglt and the beta chain portion contains three complementarity determining regions (cdrs): cdr1β: dfqatt cdr2β: snegska cdr3β: comprising sardggeg or comprising or consisting of rdggegsetqy, or wherein up to three amino acid residues in one or more cdrs are replaced by another amino acid residue. The invention also includes polynucleotides encoding the tcr molecules, and host cells containing the said polynucleotides.
Imperial Innovations Limited


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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