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Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
09/11/14
20140259231
 Multi-gene expression vehicle patent thumbnailMulti-gene expression vehicle
A multigene expression vehicle (mgev) consisting essentially of a polynucleotide comprising 2 to 8 domain segments, d, each domain encoding a functional protein, each domain being joined to the next in a linear sequence by a linker (l) segment encoding a linker peptide, the d and l segments all being in the same reading frame, and at least one of the domains is not a type two protease inhibitor.. .
09/11/14
20140259218
 Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement patent thumbnailNucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
Recombinant polynucleotides and recombinant polypeptides useful for improvement of plants are provided. The disclosed recombinant polynucleotides and recombinant polypeptides find use in production of transgenic plants to produce plants having improved properties..
09/11/14
20140259217
 Polynucleotides and polypeptides involved in post-transcriptional gene silencing patent thumbnailPolynucleotides and polypeptides involved in post-transcriptional gene silencing
This invention relates to isolated nucleic acid fragments encoding polypeptides involved in post-transcriptional gene silencing. The invention also relates to construction of a recombinant dna construct encoding all or a portion of the polypeptide involved in post-transcriptional gene silencing, in sense or antisense orientation, wherein expression of the recombinant dna construct results in production of altered levels in a transformed host cell of the polypeptide involved in post-transcriptional gene silencing..
09/11/14
20140256802
 Dual-aav vector-based systems and methods for delivering oversized genes to mammalian cells patent thumbnailDual-aav vector-based systems and methods for delivering oversized genes to mammalian cells
Disclosed are materials and methods for treating diseases of the mammalian eye, and in particular, usher syndrome 1b (ush1b). The invention provides aav-based, dual-vector systems that facilitate the expression of full-length proteins whose coding sequences exceed that of the polynucleotide packaging capacity of an individual aav vector.
09/11/14
20140256800
 Fev mini-promoters patent thumbnailFev mini-promoters
Isolated polynucleotides comprising a fev mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
09/11/14
20140256575
 Synthesis of long fish probes patent thumbnailSynthesis of long fish probes
A method comprising: synthesizing a set of overlapping oligonucleotides that comprises probe sequences that hybridize to unique sequences in a chromosome, assembling the overlapping oligonucleotides in a way that produces one or more double stranded polynucleotides that each comprises multiple probe sequences, labeling the one or more double stranded polynucleotides to produce one or more labeled probes, and hybridizing the labeled probes to an intact chromosome, in situ, is provided.. .
09/11/14
20140256029
 Apparatus for polynucleotide detection and quantitation patent thumbnailApparatus for polynucleotide detection and quantitation
An apparatus for expression profiling analysis, subjecting biological materials to polynucleotide extraction, amplification and analysis. The apparatus include an amplification device which permits the amplification of polynucleotides and an analysis device which quantifies the amount of the amplified polynucleotide products.
09/11/14
20140256020
 In situ expression of lipase for enzymatic production of alcohol esters during fermentation patent thumbnailIn situ expression of lipase for enzymatic production of alcohol esters during fermentation
Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.. .
09/11/14
20140256000
 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same patent thumbnailPolypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention provides isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides, catalytic domains, cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains..
09/11/14
20140255998
 Polypeptides having endoglucanase activity and polynucleotides encoding same patent thumbnailPolypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
09/11/14
20140255997
Glucoamylase variants and polynucleotides encoding same
The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
09/11/14
20140255990
Genetic element that enhances protein translation
The present invention provides isolated polynucleotides that can serve as translation enhancing elements and their use in protein expression reagents and methods.. .
09/11/14
20140255921
Enzyme method
The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide.
09/11/14
20140255918
Compositions, devices, systems, and methods for using a nanopore
The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore.
09/11/14
20140255468
Modified polynucleotides encoding programmed cell death 1
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
09/11/14
20140255467
Modified polynucleotides encoding cytotoxic t-lymphocyte-associated protein 4
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
09/11/14
20140255437
Topk peptides and vaccines including the same
The present invention provides isolated epitope peptides derived from topk and immunogenic fragments thereof have an ability to induce cytotoxic t lymphocytes (ctls) and thus are suitable for use in cancer immunotherapy, more particularly as cancer vaccines. The peptides of the present invention encompass both of peptides including a topk-derived amino acid sequence and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted and/or added, provided such modified versions have ctl inducibility.
09/11/14
20140255415
Lingo binding molecules and pharmaceutical use thereof
The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human lingo polypeptide, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with axonal degeneration and demyelination.. .
09/11/14
20140255411
Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against vsig1, ildr1, loc253012, ai216611, c1orf32 or fxyd3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages.
09/11/14
20140255401
Kv1.3 antagonists and methods of use
The present invention relates to kv1.3 antagonists, and polynucleotides encoding them, and methods of making and using the foregoing.. .
09/11/14
20140255389
Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against vsig1, ildr1, loc253012, ai216611, c1orf32 or fxyd3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages.
09/11/14
20140255388
Toll like receptor 3 antagonists, methods and uses
Toll like receptor 3 (tlr3) antagonists, polynucleotides encoding tlr3 antagonists or fragments, and methods of making and using the foregoing are disclosed.. .
09/04/14
20140250552
Compositions and methods to control insect pests
Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a coleopteran plant pest or a diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant.
09/04/14
20140250547
Plant expression constructs comprising and uses thereof
Methods of expressing a molecule of interest in a plant are disclosed. One method comprises contacting roots of the plant in a solution comprising at least one geminivirus based expression construct so as to allow the at least one geminivirus based expression construct to be absorbed by the roots, the expression construct comprising a polynucleotide encoding the molecule of interest, and further the expression construct being capable of systemic symptomless spread in a plant host, thereby expressing a molecule of interest in a plant.
09/04/14
20140249208
Modified polynucleotides for treating protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
09/04/14
20140249027
Novel glyphosate-n-acetyltransferase (gat) genes
Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds.
09/04/14
20140248701
Dcx mini-promoters
Isolated polynucleotides comprising a dcx mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
09/04/14
20140248687
Methods for expressing polypeptides in hyperthermophiles
Provided herein are genetically engineered archaea. A genetically engineered archaea includes a heterologous polynucleotide that has a promoter operably linked to a coding region, where the coding region encodes a polypeptide having optimal activity below the optimum growth temperature (topt) of the genetically engineered archaeon.
09/04/14
20140248674
Polypeptides having peroxygenase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
09/04/14
20140248671
Methods of increasing secretion of polypeptides having biological activity
The present invention relates to methods for producing a secreted polypeptide having biological activity, comprising: (a) transforming a fungal host cell with a fusion protein construct encoding a fusion protein, which comprises: (i) a first polynucleotide encoding a signal peptide; (ii) a second polynucleotide encoding at least a catalytic domain of an endoglucanase or a portion thereof; and (iii) a third polynucleotide encoding at least a catalytic domain of a polypeptide having biological activity; wherein the signal peptide and at least the catalytic domain of the endoglucanase increases secretion of the polypeptide having biological activity compared to the absence of at least the catalytic domain of the endoglucanase; (b) cultivating the transformed fungal host cell under conditions suitable for production of the fusion protein; and (c) recovering the fusion protein, a component thereof, or a combination thereof, having biological activity, from the cultivation medium.. .
09/04/14
20140248667
Enhancing spinosyn production with oxygen binding proteins
The invention describes the integration of polynucleotides into chromosomal dna of s. Spinosa species, which are useful for the production of insecticides, integrants thereof, and also to the use of the integrants.
09/04/14
20140248663
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Provided are isolated polypeptides having cellobiohydrolase activity, catalytic domains and cellulose binding domains, and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains..
09/04/14
20140248662
Host cell for the production of a compound of interest
The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell.
09/04/14
20140248661
Zcytor19 polynucleotides, polypeptides, antibodies and methods of use
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class ii cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo.
09/04/14
20140248624
Dna recombination junction detection
The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide.. .
09/04/14
20140248607
Brucella phage polynucleotides and uses thereof
An isolated polynucleotide is disclosed which comprises a nucleic acid sequence of a brucella phage, the nucleic acid sequence being specific to the brucella phage and comprising a sequence selected from the group consisting of seq id nos: 387-393. An exemplary polynucleotide sequence is one which comprises at least 100 consecutive nucleotides of a nucleic acid sequence as set forth in seq id no: 396.
09/04/14
20140248334
Peptides that target dorsal root ganglion neurons
The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (drg) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example.
09/04/14
20140248267
Anti-cd33 antibodies and methods for treatment of acute myeloid leukemia using the same
The present invention relates to antibodies that bind cd33. More particularly, the invention relates to anti-cd33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved versions of these antibodies, immunoconjugates and compositions comprising these antibodies, and the uses of same in diagnostic, research and therapeutic applications.
08/28/14
20140245499
Sorghum plants having a mutant polynucleotide encoding the large subunit of mutated acetohydroxyacid synthase protein and increased resistance to herbicides
A sorghum seed comprising in its genome at least one polynucleotide encoding a polypeptide having an alanine to threonine substitution at position 93 of the sorghum ahas protein large subunit. The plant has increased resistance to one or more herbicides, for example from the imidazolinone group, as compared to wild-type sorghum plants.
08/28/14
20140245498
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/28/14
20140245497
Drought tolerant plants and related constructs and methods involving genes encoding ferredoxin family proteins
Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferredoxin family protein..
08/28/14
20140245491
Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
08/28/14
20140243232
Nucleic acid complexity reduction
In some embodiments, the present teachings provide compositions, systems, methods and kits for reducing the complexity of nucleotide sequences in a nucleic acid sample comprising the steps: hybridizing a plurality of polynucleotide constructs to at least one blocker oligonucleotide and to at least one capture oligonucleotide, wherein the plurality of polynucleotide constructs include a plurality of polynucleotides each joined to at least one nucleic acid adaptor, wherein the at least one nucleic acid adaptor can hybridize to the at least one blocker oligonucleotide, and wherein the at least one capture oligonucleotide can hybridize to at least a portion of target polynucleotides that are a sub-population of the plurality of polynucleotides, so as to produce a capture duplex.. .
08/28/14
20140243203
Gene switch compositions and methods of use
Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound.
08/28/14
20140242674
Pentose fermentation by a recombinant microorganism
The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.. .
08/28/14
20140242648
Protein having activity to promote fatty acid chain elongation, gene encoding same and use thereof
The present invention relates to a protein having an activity to promote fatty acid chain elongation, a polynucleotide encoding the same, etc. The present invention provides, for example, a polynucleotide containing the nucleotide sequence shown in seq id no: 1 or 4, a polynucleotide encoding a protein which consists of the amino acid sequence shown in seq id no: 2, an expression vector and a transformant, each containing such a polynucleotide, a method for preparing lipids or fatty acids by using such a transformant, or a food or the like containing lipids or fatty acids prepared by such a method..
08/28/14
20140242638
Transcription unit and use thereof in (yb2/0) expression vectors
A transcription unit constituted by a polynucleotide including the hcmvie virus enhancer, the enhancer having the nucleotide sequence seq id no: 1, or a nucleotide acid having at least 70% sequence identity with the sequence seq id no: 1 and essentially having transcription activation properties, and the promoter region of cyclin-dependent kinase 9 (cdk9), the promoter region having the nucleotide sequence seq id no: 2, or a nucleotide acid having at least 70% sequence identity with the sequence seq id no: 2 and essentially having a promoter activity.. .
08/28/14
20140242587
Rapid and reliable detection of infectious agents
The present invention is directed to devices, systems and methods that enable the detection of low copy numbers of bacterial polynucleotides in a sample without having to use multiple species specific primer sequences.. .
08/28/14
20140242579
Reversible terminator molecules and methods of their use
The present invention relates generally to methods of sequencing of polynucleotides and compounds, compositions and kits useful for sequencing of polynucleotides. The chemical compounds include nucleotide and nucleoside analogs which possess a blocking group covalently attached to the 3′ hydroxyl of the sugar moiety.
08/28/14
20140242576
Methods for determining nucleotide sequence repeats
The invention relates to methods to reduce the length of a homonucleotide repeat sequence a target dna sequence. This is done by using an oligonucleotide primer which extends in the unaltered repeat of identical nucleotides of the target polynucleotide, the oligonucleotide primer comprises at the at the 5′ side a sequence which hybridizes with the sequence preceding the targeted sequence repeat, but the oligonucleotide primer is not 100% complementary with the sequence repeat in the target sequence..
08/28/14
20140242574
Codon-optimized gene for mutated shrimp luciferase and method for use thereof
There has been a demand for a codon-optimized gene for the mutated catalytic domain of oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than that of native 19 kda protein.
08/28/14
20140242102
Influenza hemagglutinin and neuraminidase variants
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.. .
08/28/14
20140242086
Polynucleotides encoding signal peptide-containing molecules
The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/28/14
20140242080
Bispecific t cell activating antigen binding molecules
The present invention generally relates to novel bispecific antigen binding molecules for t cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides.
08/28/14
20140242079
Bispecific t cell activating antigen binding molecules
The present invention generally relates to novel bispecific antigen binding molecules for t cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides.
08/21/14
20140237682
Regulatory polynucleotides and uses thereof
The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants.
08/21/14
20140237681
Methods and compositions for targeted polynucleotide modification
A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excise a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism..
08/21/14
20140235823
Fusion protein containing a single-stranded dna binding protein and methods for expression and purification of the same
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein.
08/21/14
20140235527
Composition for treatment or prevention of erectile dysfunction including dkk2 protein or dkk2 gene thereof and use of the composition
A pharmaceutical composition for regenerating an endothelial cell which includes as an active ingredient a dkk2 protein or a polynucleotide encoding the dkk2 protein, a pharmaceutical composition for preventing or treating erectile dysfunction, a method of regenerating an endothelial cell of a subject and a method of preventing or treating erectile dysfunction of a subject and which treat or prevent erectile dysfunction in a subject.. .
08/21/14
20140235508
Nucleic acid linker
A nucleic acid linker is for producing a complex of mrna and a protein encoded by that mrna, comprising one 3′-terminal region and two branched 5′-terminal regions, wherein the 3′-terminal region comprises a single-stranded polynucleotide segment able to hybridize with the sequence on the 3′-terminal side of the mrna, and an arm segment that branches off from the single-stranded polynucleotide segment and has a linking segment with the protein on the terminal thereof, and one of the two 5′-terminal regions has a binding site with the 3′-terminal of the mrna.. .
08/21/14
20140235506
Polynucleotide barcode generation
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
08/21/14
20140235498
Enhanced throughput mineral coatings for optimization of stem cell behavior
Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells.
08/21/14
20140235457
Systems and methods for genetic and biological analysis
The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput.
08/21/14
20140234976
Compositions and methods for conferring herbicide resistance
The present invention provides a protein, specifically parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism.
08/21/14
20140234969
Methods for enhancing genome stability and telomere elongation in embryonic stem cells
The disclosure provides methods for increasing genome stability of an embryonic stem (es) cell or induced pluripotent stem (ips) cell, increasing telomere length in an es or ips cell, or both, for example by contacting an es or ips cell with an agent that increases expression of zscan4 in the cell. Methods for increasing genome stability or increasing telomere length in a population of es or ips cells are provided, for example by selecting zscan4+ es or ips cells from the population of es or ips cells (which can include both zscan4+ and zscan4− es or ips cells).
08/21/14
20140234925
Methods for improving malic acid production in filamentous fungi
The present invention relates to methods of producing a c4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a c4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the c4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the c4 dicarboxylic acid. The present invention also relates to methods for increasing c4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants..
08/21/14
20140234924
Variants of glycerol dehydrogenase having d-lactate dehydrogenase activity and uses thereof
The present invention provides methods of designing and generating glycerol dehydrogenase (glydh) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding glydh polypeptide variants having altered function as compared to the parent polypeptide.
08/21/14
20140234918
Polypeptides having peroxygenase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/21/14
20140234907
Polypeptides having endoglucanase activity and polynucleotides encoding same
Provided are isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/21/14
20140234906
Alpha-amylase variants and polynucleotides encoding same
The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
08/21/14
20140234897
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Disclosed are isolated polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. Furthermore, nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains are disclosed..
08/21/14
20140234533
Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
08/21/14
20140234373
Methods of promoting immune tolerance
Compositions including a polynucleotide combined with a vehicle and methods of their use to induce a suppressive immune response are provided. In some embodiments the compositions induce an increase in expression of indoleamine 2,3 dioxygenase (ido) enzyme activity in cells.
08/21/14
20140234357
H5 proteins of h5n1 influenza virus for use as a medicament
The present invention is based on the surprising finding that h5 protein of clade 1 h5n1 induces, in particular by a single-shot vaccination, a cross-clade protective immune response to influenza viruses with h5n1 ha. In one aspect, the invention is thus directed to h5 protein of clade 1 h5n1 virus for use in a method of treating or preventing infections with h5n1 virus of a different clade, wherein the h5n1 virus of a different clade comprises a particular polynucleotide and/or h5 protein..
08/21/14
20140234322
Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury
Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non-human mammal.
08/21/14
20140234313
Soluble polypeptides
The invention relates generally to polypeptides, such as antibody molecules, that demonstrate high stability and solubility. In particular, the invention relates to polypeptides comprising paired vl and vh domains that demonstrate soluble expression and folding in a reducing or intracellular environment.
08/21/14
20140234285
Method for therapeutic angiogenesis
The present invention relates to the e2epf ucp-vhl interaction and the uses thereof, more precisely a method for increasing or reducing vhl activity or level by regulating ucp activity or level to inhibit cancer cell proliferation or metastasis or to increase angiogenesis. The inhibition of ucp activity is accomplished by any ucp activity inhibitor selected from a group consisting of a small interfering rna (rnai), an antisense oligonucleotide, and a polynucleotide complementarily binding to mrna of ucp, a peptide, a peptide mimetics and an antibody, and a low molecular compound.
08/21/14
20140234262
Novel nylanderia fulva virus
At least one novel virus capable of infecting crazy ants (nylanderia fulva) is isolated, along with polynucleotide sequences and amino acid sequences of the virus. The virus is capable of be used as a biopesticide to control populations of crazy ants..


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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