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Polynucleotide

Polynucleotide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Models for analyzing data from sequencing-by-synthesis operations
Life Technologies Corporation
October 12, 2017 - N°20170293713

A method of modeling a background signal when sequencing a polynucleotide strand using sequencing-by-synthesis includes: flowing a series of nucleotide flows onto a reactor array having multiple reaction confinement regions, one or more copies of the polynucleotide strand being located in a loaded reaction confinement region of the reactor array, the loaded reaction confinement region being located in a vicinity ...
Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
Applied Biosystems, Llc
October 12, 2017 - N°20170292158

The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific ...
Cellobiohydrolase variants and polynucleotides encoding same
Novozymes A/s
October 12, 2017 - N°20170292136

The present invention relates to cellobiohydrolase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
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Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna ...
Pangu Biopharma Limited
October 12, 2017 - N°20170291960

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Antibody therapeutics that bind cd38
Sorrento Therapeutics, Inc.
October 12, 2017 - N°20170291959

There is disclosed compositions and methods relating to or derived from anti-cd38 antibodies. More specifically, there is disclosed fully human antibodies that bind cd38, cd38-antibody binding fragments and derivatives of such antibodies, and cd38-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, ...
Glypican-3 antibody and uses thereof
The Trustees Of The University Of Pennsylvania
October 12, 2017 - N°20170291954

The present invention relates to compositions and methods of isolated polynucleotides that encode or polypeptides comprising glypican-3 (gpc3). The invention also includes a chimeric antigen receptor (car) wherein the car is able to target gpc3. The invention further includes methods of treating a subject or diagnosing and treating diseases, disorders or conditions associated with dysregulated glypican-3.
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Polynucleotide Patent Applications
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Production cell line enhancers
Regeneron Pharmaceuticals, Inc.
October 12, 2017 - N°20170291938

The present invention relates to discovery of the ectopic expression of edem2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell, the cho cell, containing recombinant polynucleotides encoding edem2. Also disclosed is a production cell containing both an edem2...
Adeno-associated viral vectors for the gene therapy of metabolic diseases
Universitat Autonoma De Barcelona
October 12, 2017 - N°20170290926

The present invention discloses adeno-associated viral vectors useful in gene therapy methods for the treatment of obesity, insulin resistance, type 2 diabetes, liver cirrhosis and non-alcoholic fatty liver disease (nafld)/non-alcoholic steatohepatitis (nash). The invention also relates to polynucleotides, plasmids, vectors and methods for the production of such adeno-associated viral vectors. The invention also relates to pharmaceutical compositions comprising said vectors.
Anti-lag3 antibodies and antigen-binding fragments
Merck Sharp & Dohme Corp.
October 12, 2017 - N°20170290914

The present invention includes antibodies and antigen-binding fragments thereof that specifically bind to human or cynomolgous monkey lag3 as well as immunoglobulin chains thereof and polynucleotides encoding the same along with injection devices comprising such antibodies or fragments. Vaccines including such antibodies and fragments as well as compositions comprising the antibodies and fragments (e. G., including anti-pd1 antibodies) are included ...
Multicomponent or monocomponent vaccine to be used against chagas disease, pharmaceutical compositions containing them, procedure ...
Merck Sharp & Dohme Corp.
October 12, 2017 - N°20170290896

A monocomponent vaccine effective to moderate the clinical consequences of chages disease, capable of stimulating an immune response against the trans-sialidase virulence factor of the trypanosoma cruzi parasite. The vaccine active ingredient is an immunogenic component with a polynucleotide encoding one or more polypeptide(s) which includes a c-terminal region composed of at least two repetitive units of amino acids, ...
Compositions and methods for the treatment of wounds, disorders, and diseases of the skin
Krystal Biotech, Llc
October 12, 2017 - N°20170290866

The present disclosure relates, in part, to pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of collagen alpha-1 (vii) chain polypeptide and/or lysyl hydroxylase 3 polypeptide and/or keratin type i cytoskeletal 17 polypeptide in a subject. The present disclosure also relates, in part, to pharmaceutical compositions and methods of use for ...
Insecticidal cry toxins
Dow Agrosciences Llc
October 12, 2017 - N°20170290340

Insecticidal toxins derived from bacillus thuringiensis, polynucleotides encoding such toxins, use of such toxins to control coleopteran plant pests, and transgenic plants that produce, and are protected, by these toxins are described.
Compositions and methods to control insect pests
E I Du Pont De Nemours And Company
October 12, 2017 - N°20170290338

Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a coleopteran plant pest or a diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of ...
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Dna detection methods for site specific nuclease activity
Dow Agrosciences Llc
October 05, 2017 - N°20170283865

The present disclosure provides methods for detecting and identifying plant events that contain precision targeted genomic loci, and plants and plant cells comprising such targeted genomic loci. The method can be deployed as a high throughput process utilized for screening the intactness or disruption of a targeted genomic loci and optionally for detecting a donor dna polynucleotide insertion at the ...
Carbohydrate binding module variants and polynucleotides encoding same
Novozymes A/s
October 05, 2017 - N°20170283843

The present invention relates to cellobiohydrolase variants and carbohydrate binding module variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
Methods to improve plant-based food and feed
Plant Sensory Systems, Llc.
October 05, 2017 - N°20170283821

The present invention describes an alternative approach to increase taurine (tau) or methionine (met) production in eukaryotes, namely by the insertion of components of a sulfur-metabolic pathway and tau- or met-binding proteins in organisms where the peptides do not exist or have not clearly been identified. The invention describes methods for the use of polynucleotides that encode functional cysteine dioxygenase (...
Polypeptides having beta-xylosidase activity and polynucleotides encoding same
Novozymes Inc.
October 05, 2017 - N°20170283817

The present invention relates to isolated polypeptides having beta-xylosidase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Compositions and methods for modulating expression of nucleic acids
Syngenta Participations Ag
October 05, 2017 - N°20170283815

The invention relates to synthetic mirna precursor molecules and methods for the use of the mirna precursor molecules in modulating the expression of target polynucleotides
Downregulating mir-132 for the treatment of lipid related disorders
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
October 05, 2017 - N°20170283800

A method of treating a lipid-related disorder in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polynucleotide agent which is substantially complementary to a nucleotide sequence of human mir-132, thereby treating the lipid related disorder in the subject.
Compositions and methods relating to synthetic rna polynucleotides created from synthetic dna oligonucleotides
New England Biolabs, Inc.
October 05, 2017 - N°20170283797

Compositions and methods are provided for forming a single rna polynucleotide from a plurality of dna oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. Dna polymerase, rna polymerase and single stranded (ss) dna oligonucleotides are combined where each dna oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss ...
Methods for selecting and amplifying polynucleotides
Illumina, Inc.
October 05, 2017 - N°20170283794

The invention provides methods for generating a nucleic acid library. Target-specific primer-probes are hybridized to a target nucleic acid fragment to create a hybridization product. Each of the target-specific primer-probes comprises a target-specific sequence and a first adaptor sequence. The target nucleic acid fragment comprises a target genomic region of interest, wherein said target genomic region of interest comprises an ...
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