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Polynucleotide patents



      

This page is updated frequently with new Polynucleotide-related patent applications.




Date/App# patent app List of recent Polynucleotide-related patents
06/23/16
20160177398 
 Dna methylation biomarkers for bladder cancer patent thumbnailnew patent Dna methylation biomarkers for bladder cancer
A method for the prediction, prognosis and/or diagnosis of bladder cancer or bladder cancer recurrence in a subject, the method includes: providing a test sample from the subject; measuring dna methylation levels of at least a portion of two or more polynucleotides selected from the group consisting of hoxa9, soxi, npy, irak3, l1-met, and z02 in the test sample; calculating a risk score based on the measured dna methylation levels, comparing the calculated risk score to a cut-off value derived from a reference dna methylation profile based on dna methylation levels of the one or more biomarkers derived from a control group, members of which had bladder cancer; and based on the comparison calculated risk score to the cut-off value, determining at least one of: (1) whether bladder cancer has recurred; (2) whether there is likelihood that the bladder cancer will recur; and (3) whether the patient has bladder cancer.. .

06/23/16
20160177395 
 Biomarkers for the prediction of renal injury patent thumbnailnew patent Biomarkers for the prediction of renal injury
The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucelotides and proteins, and to kits utilizing same.. .

06/23/16
20160177343 
 Polypeptides having glucoamylase activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having glucoamylase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..

06/23/16
20160177336 
 Expression tools for multiprotein applications patent thumbnailnew patent Expression tools for multiprotein applications
Polynucleotides for multigene applications comprising a novel functional arrangement, as well as vectors, host cells, and recombinant animals comprising the polynucleotides are described. Methods for generating multigene expression cassettes, methods for producing multiprotein complexes in vitro and in vivo, and methods for producing a vaccine are also disclosed.

06/23/16
20160177333 
 Pesticidal genes and methods of use patent thumbnailnew patent Pesticidal genes and methods of use
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the polypeptides, dna constructs and vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the polypeptides.

06/23/16
20160177332 
 Axmi281 toxin gene and methods for its use patent thumbnailnew patent Axmi281 toxin gene and methods for its use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.

06/23/16
20160177329 
 Method of inhibiting sprouting in plant tissues patent thumbnailnew patent Method of inhibiting sprouting in plant tissues
The present invention relates to a method for inhibiting sprouting, particularly pre-harvest sprouting, in plant seeds, by introducing a polynucleotide encoding a fca protein into the plant.. .

06/23/16
20160177308 
 Therapeutic polynucleotides, compositions, and methods patent thumbnailnew patent Therapeutic polynucleotides, compositions, and methods
This disclosure describes, in one aspect, a composition that generally includes an xna molecule comprising at least six nucleotides, in an amount effective to improve at least one indicator of myocyte function and a pharmaceutically acceptable carrier. In another aspect, this disclosure describes a method of treating cardiac disease.

06/23/16
20160177282 
 Polypeptides having cellobiohydrolase i activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having cellobiohydrolase i activity and polynucleotides encoding same
The present invention relates to polypeptides having cellobiohydrolase i activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides..

06/23/16
20160177280 
 Alpha-amylase variants and polynucleotides encoding same patent thumbnailnew patent Alpha-amylase variants and polynucleotides encoding same
The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..

06/23/16
20160176963 
new patent

Antibodies to tigit


The present invention provides antibodies, or antigen binding fragments thereof, that bind to human tigit (t cell immunoreceptor with ig and itim domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the pd-1/pd-l1 interaction.

06/23/16
20160176936 
new patent

Mps peptides and use thereof


This disclosure provides an isolated polypeptide comprising no more than 35 amino acids, wherein the amino acid sequence comprises, or alternatively consists essentially of, or alternatively consisting of xxxrysyxxsyx (seq id no: 1) and equivalents thereof, wherein x is a basic amino acid and y is a hydrophobic amino acid. Polynucleotides encoding the polypeptides and antibodies that bind to the polypeptides are also provided.

06/23/16
20160175424 
new patent

Haemophilus influenzae type iv pili


The invention described herein relates to a haemophilus influenzae (h. Influenzae) regulon encoding type iv pili.

06/23/16
20160175406 
new patent

Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders


The present invention relates to methods and materials useful for systemically delivering polynucleotides across the blood brain barrier using adeno-associated virus as a vector. For example, the present invention relates to methods and materials useful for systemically delivering α-n-acetylglucosamidinase polynucleotides to the central and peripheral nervous systems, as well as the somatic system.

06/23/16
20160175370 
new patent

Targeting of herpes simplex virus to specific receptors


The invention relates to engineered herpes simplex virus (hsv) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such hsv particles are provided.

06/23/16
20160174589 
new patent

Polypeptides having beta-1,3-galactanase activity and polynucleotides encoding same


The present invention relates to polypeptides having beta-1,3-galactanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..

06/16/16
20160169875 

Nucleic acid sensor for melamine analysis, device for melamine analysis, and melamine analysis


The present invention is to provide a new sensor for melamine detection. The nucleic acid sensor for melamine analysis of the present invention includes a polynucleotide (x1) that includes a catalytic nucleic acid molecule (d) that activates a catalytic function and a binding nucleic acid molecule (a) that binds to melamine.
Nec Solution Innovators, Ltd.


06/16/16
20160168629 

Self-assembled single molecule arrays and uses thereof


The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations.
Callida Genomics, Inc.


06/16/16
20160168611 

Methods and synthesizing nucleic acids


The invention provides improved methods for synthesizing polynucleotides, such as dna and rna, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.
Molecular Assemblies, Inc.


06/16/16
20160168609 

Enhanced cellulose degradation


The present disclosure provides compositions and methods related to the degradation of cellulose and cellulose-containing materials. Cdh-heme domain polypeptides and gh61 polypeptides and related polynucleotides and compositions are provided herein.
The Regents Of The University Of California


06/16/16
20160168600 

3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase


Provided herein are recombinant yeast cells having an active 3-hydroxypropionic acid (3-hp) pathway and further comprising a heterologous polynucleotide encoding an aspartate 1-decarboxylase (adc) of the class insecta, bivalvia, branchioporia, gastropoda, or leptocardii. Also described are methods of using the recombinant yeast cells to produce 3-hp and acrylic acid..
Novozymes A/s


06/16/16
20160168587 

Methods and compositions for plant pest control


The present invention comprises methods and compositions for controlling nematode parasitism in host plant. The present invention comprises novel polynucleotides and polypeptides encoded by such polynucleotides comprising one or more nucleic acid sequences disclosed herein having a nucleotide sequence comprising any one of seq id no: 1-142 or 161, a fragment or variant thereof, or a complement thereof, or a polypeptide sequence comprising any one of seq id no: 143-160, a fragment or variant thereof..
The Curators Of The University Of Missouri


06/16/16
20160168586 

Corn plant event mon87460 and compositions and methods for detection thereof


The present invention provides a transgenic corn event mon87460, and cells, seeds, and plants comprising dna diagnostic for the corn event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for mon87460 in a sample, methods for detecting the presence of mon87460 event polynucleotides in a sample, and probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of mon87460 in a sample.
Monsanto Technology Llc


06/16/16
20160168574 

Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an insulin gene (ins), in particular, by targeting natural antisense polynucleotides of an insulin gene (ins). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of insulin gene (ins)..
Curna, Inc.


06/16/16
20160168568 

Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq)


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an adiponectin (adipoq), in particular, by targeting natural antisense polynucleotides of an adiponectin (adipoq). The invention also relates to the identification of these antisaese oligonucleotides and their use in treating diseases and disorders associated with the expression of adiponectins (adipoq)s..
Curna, Inc.


06/16/16
20160168557 

Modified beta-lactamases and methods and uses related thereto


Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.. .

06/16/16
20160168552 

Cellulases, nucleic acids encoding them and methods for making and using them


This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or β-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides.
Bp Corporation North America Inc.


06/16/16
20160168551 

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novoyzmes A/s


06/16/16
20160168547 

Polypeptides having lipase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
Novozymes A/s


06/16/16
20160168545 

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds


The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. .
Codexis, Inc.


06/16/16
20160168264 

Antibodies directed to her-3 and uses thereof


The present invention relates to binding proteins that bind to her-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided.
Amgen, Inc.


06/16/16
20160168263 

Certain improved human bispecific egfrviii antibody engaging molecules


We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human egfrviii mutant protein on its surface, and a second arm that specifically engages t cell activation ligand cd3. The polynucleotide is codon optimized for expression in cho cells.
The Government Of The U.s. As Represented By The Secretary Of Health


06/16/16
20160166666 

Tumor antigen peptide


Provided is a tumor antigen peptide and the like that is useful in the prevention and/or treatment of cancer. The present invention pertains to: a peptide comprising the amino acid sequence of sequence number 3, sequence number 4, sequence number 5, sequence number 6, or sequence number 11; a polyepitope peptide resulting from joining a plurality of epitope peptides and containing at least one of the aforementioned peptides as one epitope peptide; a polynucleotide coding for at least one of the polyepitope peptides or the peptides; a pharmaceutical composition containing the above as active ingredients; a cancer prevention and/or treatment agent characterized by inducing ctls; and the like..
Sapporo Medical University


06/16/16
20160166665 

Cellular immunity inducing vaccine


A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an mhc class i epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo.
The Jikei University


06/16/16
20160166657 

Factor ix polypeptides and methods of use thereof


The present invention provides methods of administering factor ix; methods of administering chimeric and hybrid polypeptides comprising factor ix; chimeric and hybrid polypeptides comprising factor ix; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.. .
Biogen Hemophilia Inc.


06/09/16
20160160277 

Method for sequencing a polynucleotide template


The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for sequence determination may or may not be complementary to each other..
Illumina Cambridge Limited


06/09/16
20160160224 

Cryptosporidium transfection methods and transfected cryptosporidium cells


This disclosure describes, in one aspect, a method of transfecting a cryptosporidium organism. Generally, the method includes introducing into a cryptosporidium organism a heterologous polynucleotide comprising at least one coding region, and incubating the cryptosporidium organism under conditions effective for the cryptosporidium organism to express the coding region..
University Of Georgia Research Foundation, Inc.


06/09/16
20160160215 

Polynucleotides for multivalent rna interference, compositions and methods of use thereof


The present invention includes bivalent or multivalent nucleic acid molecules or complexes of nucleic acid molecules having two or more target-specific regions, in which the target-specific regions are complementary to a single target gene at more than one distinct nucleotide site, and/or in which the target regions are complementary to more than one target gene or target sequence. Also included are compositions comprising such nucleic acid molecules and methods of using the same for multivalent rna interference and the treatment of a variety of diseases and infections..
Halo-bio Rnai Therapeutics, Inc.


06/09/16
20160160214 

Formulations comprising antisense nucleotides to connexins


A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.. .
Coda Therapeutics, Inc.


06/09/16
20160160211 

Two dimensional capillary electrophoresis apparatus


The present disclosure describes an apparatus for identifying a polynucleotide capable of binding a target. The apparatus comprises a first, second, and third high voltage power supply; a first, second, and third capillary tube; a first, second, and third buffer reservoir; a fraction collector, and at least one collection vessel..
University Of Notre Dame Du Lac


06/09/16
20160160202 

Novel metalloproteases


Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.. .
Danisco Us Inc.


06/09/16
20160160201 

Polypeptides having cellobiohydrolase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


06/09/16
20160160196 

Polypeptides with lipase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides with lipase activity, selected from the group consisting of: (a) a polypeptide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to seq id no: 2; (b) a polypeptide encoded by a polynucleotide that hybridizes under low stringency conditions, medium stringency conditions, medium-high stringency conditions, high stringency conditions, or very high stringency conditions with (i) seq id no: 1 or the full-length complement of (i); (c)a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to seq id no: 1; (d) a polypeptide which is a variant of seq id no: 2 comprising a substitution, deletion, and/or insertion at one or more (e.g. Several) positions; and(e)a polypeptide which is a fragment of any of the polypeptides of (a), (b), (c) or (d).
Novozymes A/s


06/09/16
20160160187 

Ketoreductase-mediated stereoselective route to alpha chloroalcohols


The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
Codexis, Inc.


06/09/16
20160159926 

Fusion polynucleotide containing murine cmv promoter and preparing a polypeptide of interest using the same


A fusion polynucleotide including a murine cmv promoter and an intron, a recombinant vector including the fusion polynucleotide and a gene encoding a polypeptide of interest, a recombinant cell including the recombinant vector, and a method of producing a polypeptide of interest using the recombinant vector and/or the recombinant cell.. .
Samsung Bioepis Co., Ltd.


06/09/16
20160159917 

Trimeric antigen binding molecules


The present invention pertains to a trimeric antigen binding molecule comprising three fusion polypeptides, each comprising at least one antigen binding moiety fused to a trimerization domain derived from human cartilage matrix protein. In addition, the present invention relates to polynucleotides encoding such trimeric antigen binding molecules, and vectors and host cells comprising such polynucleotides.
Hoffmann-la Roche Inc.


06/09/16
20160159883 

Fibronectin based scaffold domain proteins that bind pcsk9


The present invention relates to fibronectin based scaffold domain proteins that bind pcsk9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases.
Bristol-myers Squibb Company


06/09/16
20160159878 

Nogo receptor antagonists


Disclosed are immunogenic nogo receptor-1 polypeptides, nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are nogo receptor antagonist polynucleotides.
Biogen Ma Inc.


06/09/16
20160159867 

Nucleotide sequences, vectors and host cells


Polynucleotides encoding fusion proteins comprising fragments of toxin a and toxin b from clostridium difficile are described, as well as vectors and host cells containing such polynucleotides.. .
Glaxosmithkline Biologicals S.a.


06/09/16
20160159780 

Strigolactone formulations and uses thereof


Disclosed herein plant propagation materials, methods of manufacturing, formulations and uses thereof. The plant propagation materials disclosed herein may comprise a strigolactone obtained by a biosynthetic process.
Asilomar Bio, Inc.


06/09/16
20160158385 

Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


06/09/16
20160158329 

Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis


Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise polypeptides comprising one or more leishmania antigens as well as polynucleotides encoding such polypeptides..
Infectious Disease Research Institute


06/09/16
20160158319 

Remodeling and glycopegylation of fibroblast growth factor (fgf)


The present invention relates to mutants of fibroblast growth factor (fgf), particularly fgf-20 and fgf-21, which contain newly introduced n-linked or o-linked glycosylation site(s). The polynucleotide coding sequences for the mutants, expression cassettes comprising the coding sequences, cells expressing the mutants, and methods for producing the mutants are also disclosed.
Novo Nordisk A/s


06/09/16
20160158317 

Antimicrobial peptide variants and polynucleotides encoding same


The present invention relates to variants of a parent antimicrobial peptide. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Adenium Biotech A/s


06/09/16
20160158168 

Methods for the biosynthesis of taurine or hypotaurine in cells


The present invention describes an approach to increase taurine or hypotaurine production in prokaryotes. More particularly, the invention relates to genetic transformation of organisms with genes that encode proteins that catalyze the conversion of cysteine to taurine, methionine to taurine, cysteamine to taurine, or alanine to taurine.
Plant Sensory Systems Llc


06/02/16
20160153030 

Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms


The present invention provides methods for the detection of cyanobacteria, and in particular, methods for the detection of cyanotoxic organisms. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides and/or polypeptides of the saxitoxin biosynthetic pathways..
Newsouth Innovations Pty Limited


06/02/16
20160153019 

Production of glycoproteins having increased n-glycosylation site occupancy


The present disclosure relates to compositions and methods useful for the production of heterologous proteins with increased n-glycosylation site occupancy in filamentous fungal cells, such as trichoderma cells. More specifically, the invention provides a filamentous fungal cell comprising i.
Glykos Finland Oy


06/02/16
20160152998 

Transgenic expression of archaea superoxide reductase


This invention provides a stably transformed plant, plant part and/or plant cell, comprising a heterologous polynucleotide encoding a superoxide reductase (sor) from an archaeon species, wherein said stably transformed plant, plant cell, and/or plant part has increased disease resistance. The invention further provides a method of increasing disease resistance in a plant, plant cell, or plant part, comprising: introducing into said plant, plant cell, or plant part a heterologous polynucleotide encoding a superoxide reductase from an archaeon species to produce a stably transformed plant, plant cell, or plant part, thereby producing a plant, plant part, or plant cell having increased disease resistance as compared to a control.
North Carolina State University


06/02/16
20160152995 

Methods and compositions to improve the spread of chemical signals in plants


Compositions and methods are provided which employ a chemical-gene switch which may comprise at least three components. The first component comprises a polynucleotide encoding a chemically-regulated transcriptional repressor; the second component comprises a repressible promoter operably linked to a polynucleotide of interest, and the third component comprises a gene silencing construct operably linked to a second repressible promoter, wherein the gene silencing construct encodes a silencing element that decreases the level of mrna encoding the chemically-regulated transcriptional repressor.
E.i. Du Pont De Nemours And Company


06/02/16
20160152993 

Promoters for expressing genes in a fungal cell


The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides encoding polypeptides. The present invention also relates to methods for producing such polypeptides..
Novozymes, Inc.


06/02/16
20160152992 

Promoter exhibiting high expression activity in mortierella microorganisms


The present invention provides a polynucleotide which contains any one nucleotide sequence selected from the group consisting of seq id nos: 1 to 28, or a variant thereof.. .

06/02/16
20160152991 

Recombinant protein production in heterologous systems


Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide..
Yeda Research And Development Co. Ltd.


06/02/16
20160152971 

Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunits


The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells.
Vaccinex, Inc.


06/02/16
20160152963 

Protease variants and polynucleotides encoding same


The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


06/02/16
20160152962 

Subtilase variants and polynucleotides encoding same


The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


06/02/16
20160152961 

Polypeptides having endoglucanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novoyzmes A/s


06/02/16
20160152960 

Glucoamylase variants and polynucleotides encoding same


The present invention relates to glucoamylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


06/02/16
20160152925 

Polypeptides having anti-redeposition effect and polynucleotides encoding same


The present invention relates to methods for reducing or preventing soil redeposition using a detergent composition comprising an isolated polypeptide having xanthan lyase activity optionally with a gh9 endoglucanase for dish wash and laundry. The invention also relates to polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


06/02/16
20160152698 

Anti-ngf antibodies and methods using same


The invention concerns anti-ngf antibodies (such as anti-ngf antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain..
Rinat Neuroscience Corp.


06/02/16
20160152688 

Targeted therapeutics based on engineered proteins that bind egfr


The present invention relates to single domain proteins that bind to epidermal growth factor receptor (egfr). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications.
Bristol-myers Squibb Company


06/02/16
20160152683 

Novel activin receptor and uses thereof


The present invention provides novel activin iib5 receptor polypeptides capable of binding and inhibiting the activities of activin a, myostatin, or gdf-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides.
Amgen Inc.


06/02/16
20160152678 

Modified polynucleotides for the production of oncology-related proteins and peptides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmrna molecules.. .
Moderna Therapeutics, Inc.


06/02/16
20160151516 

Modified polynucleotides for the production of proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


06/02/16
20160151478 

Novel flavivirus antigens


The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability to induce an immune response to flaviviruses. The polypeptides and polynucleotides of the invention are useful in methods of inducing immune response against flaviviruses, including dengue viruses.
Altravax, Inc.


06/02/16
20160151423 

Methods, compositions, and kits for improving pancreatic beta cell viability and treating diseases or conditions related to beta cell destruction


The present disclosure provides novel methods for increasing β-cell viability in islets by delivering rlip76 polypeptides or gsta4 polypeptides, or a combination thereof; or rlip76 polynucleotides or gsta4 polynucleotides, or a combination thereof, to the islets. The disclosure also provides novel methods for treating a disease or condition in a subject, such as type 1 diabetes mellitus, by delivering rlip76 polypeptides or gsta4 polypeptides, or a combination thereof; or rlip76 polynucleotides or gsta4 polynucleotides, or a combination thereof, to islets and transplanting the islets into the subject to treat the disease or condition.
City Of Hope


06/02/16
20160151409 

Synergistic enhancement of the delivery of nucleic acids via blended formulations


Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs. The blended compositions are generally characterized as being able to efficiently deliver polynucleotides to target cells and by their ability to enhance the expression of such polynucleotides and the production of functional proteins by target cells..
Shire Human Genetic Therapies, Inc.


06/02/16
20160150807 

Polypeptides having alpha-xylosidase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having α-xylosidase activity, catalytic domains and polynucleotides encoding the polypeptides, catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and catalytic domains..
Novozymes A/s


05/26/16
20160145667 

Methods for producing secreted polypeptides having biological activity


The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.. .
Novozymes, Inc.


05/26/16
20160145645 

Targeted integration


The present disclosure encompasses an isolated cell comprising an exogenous nucleic acid sequence located within or proximal to a predetermined genomic locus, wherein the exogenous nucleic acid sequence comprises at least one recognition sequence which can be exploited by one or more polynucleotide modification enzymes for targeted integration of a recombinant protein. The disclosure further provides methods for preparing such cells, and methods for retargeting such cells for the production of recombinant proteins, and kits for the same..
Sigma-aldrich Co. Llc


05/26/16
20160145633 

Woody plants having improved growth characteristics and making the same


The present invention pertains to a novel and extensive analytical platform for selecting genes with a possible commercial phenotype from a large group of candidate genes identified using tools in bioinformatics, data from est sequencing and dna array. An aspect of the invention provides a method of producing a transgenic plant having an increased growth compared to its wild type.
Swetree Technologies Ab


05/26/16
20160145604 

An integrated system for library construction, affinity binder screening and expression thereof


A recombinant polynucleotide suitable for use in a display vector is provided. The recombinant polynucleotide includes from 5′ to 3′: a first nucleic acid sequence (or insert) encoding an amino acid sequence to be displayed on a surface; a first pre-selected restriction site; a second nucleic acid sequence encoding a surface peptide capable of being displayed on the surface; and a second pre-selected restriction site.
Adagene Inc.


05/26/16
20160145596 

Subtilase variants and polynucleotides encoding same


The present invention relates to novel subtilase variants exhibiting increased stability and preferably on par or improved wash performance. The variants of the invention are suitable for use in e.g.
Novozymes A/s


05/26/16
20160145595 

Subtilase variants and polynucleotides encoding same


The present invention relates to novel subtilase variants exhibiting increased stability and optionally on par or improved wash performance. The variants of the invention are suitable for use in e.g.
Novozymes A/s


05/26/16
20160145594 

Protease variants and polynucleotides encoding same


The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


05/26/16
20160145592 

Glucoamylase variants and polynucleotides encoding same


The present invention relates to glucoamylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


05/26/16
20160145586 

Aad-1 event das-40278-9, related transgenic corn lines, and event-specific identification thereof


This invention relates in part to plant breeding and herbicide tolerant plants. This invention includes a novel aad-1 transformation event in corn plants comprising a polynucleotide sequence, as described herein, inserted into a specific site within the genome of a corn cell.
Dow Agrosciences Llc


05/26/16
20160145540 

Detergent compositions comprising metalloproteases


The present invention relates to the use of and compositions comprising isolated polypeptides having protease activity and polynucleotides encoding the polypeptides. The invention also relates to cleaning compositions, and the use of the polypeptides in cleaning processes..
Novozymes A/s


05/26/16
20160145354 

Bispecific t cell activating antigen binding molecules


The present invention generally relates to novel bispecific antigen binding molecules for t cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides.
Roche Glycart Ag


05/26/16
20160145351 

Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof


The present invention provides compositions and methods relating to or derived from antigen binding proteins activate fgf21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-klotho; (ii) fgfr1c, fgfr2c, fgfr3c or fgfr4; or (iii) a complex comprising β-klotho and one of fgfr1c, fgfr2c, fgfr3c, and fgfr4.
Amgen Inc.


05/26/16
20160145342 

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof


Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible tnf receptor (gitr). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer.
Bristol-myers Squibb Company


05/26/16
20160145337 

Cd19 specific chimeric antigen receptor and uses thereof


The present invention relates to chimeric antigen receptors (car). Cars are able to redirect immune cell specificity and reactivity toward a selected target exploiting the ligand-binding domain properties.
Cellectis


05/26/16
20160145292 

Phosphoroamidate esters, and use and synthesis thereof


Phosphoramidate esters and related nucleotide analogs useful in polynucleotide sequencing techniques, and synthetic methods for preparing those compounds, are disclosed. These compounds include nucleotide phosphoramidates analogs that are modified on the alpha-phosphate to enable attachment of a variety of application-specific substituents such as tether molecules..
Stratos Genomics, Inc.


05/26/16
20160144333 

Assembly of high fidelity polynucleotides


Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically, design of support-bound template oligonucleotides is disclosed.
Gen9, Inc.


05/26/16
20160144057 

Methods for expressing a polynucleotide of interest in the retina of a subject


The present invention relates to methods for expressing a polynucleotide of interest in the retina of a subject. In particular, the present invention relates to a method for expressing a polynucleotide of interest in the retina of a subject comprising the step consisting of injecting into the vitreous an amount of a vector containing the polynucleotide of interest in combination with an amount of an inhibitor of dp71 expression..
Centre National De La Recherche Scientifique (cnrs)


05/26/16
20160143969 

Gene-modified coxsackievirus


A modified coxsackievirus showing improved safety and/or aggressiveness to be used for oncolytic virotherapy is provided. A modified coxsackievirus showing tissue-specific suppression of proliferation and comprising a imitated genome consisting of the genome of coxsackievirus b3 wild-type (cvb3-wt) inserted with at least one polynucleotide consisting of a target sequence of tissue-specific micror na (mirna) is provided.
Kyushu University National University Corporation


05/26/16
20160143309 

Polypeptides having phospholipase c activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having phospholipase c activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


05/19/16
20160138117 

Complex sets of mirnas as non-invasive biomarkers for colon cancer


Described herein are non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer a body fluid sample from a subject. Further described herein are sets of polynucleotides or sets of primer pairs for detecting sets of mirnas for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject.
Comprehensive Biomarker Center Gmbh


05/19/16
20160138101 

Method and device for identifying nucleotide, and for determining nucleotide sequence of polynucleotide


The present invention provides technology that uses current measurements to identify nucleotides and determine a nucleotide sequence in polynucleotides. The present invention calculates a modal value of a tunnel current that arises when a nucleotide or polynucleotide for analysis passes through between electrodes, and then employs the calculated modal value.
Osaka University


05/19/16
20160138047 

Improved polynucleotide sequences encoding tale repeats


The present invention is in the field of the gene editing molecular tools. The present invention relates to rewritten nucleic acid sequences encoding repeated dna recognition motifs of tale (transcription activator-like effector) proteins.
Cellectis


05/19/16
20160138046 

Compositions and methods directed to crispr/cas genomic engineering systems


The invention relates to engineered crispr/cas9 systems for genomic modification in mammalian cells. The present specification describes the design and testing of a polynucleotide encoding the streptococcus pyogenes (s.
System Biosciences, Llc


05/19/16
20160138042 

Wheat stem rust resistance gene


The present invention relates to a transgenic plant which has integrated into its genome an exogenous polynucleotide encoding a polypeptide which confers resistance to puccinia graminis f sp. Tritici, such as the ug99 group of races puccinia graminis f.
Commonwealth Scientific And Industrial Research Organisation


05/19/16
20160138039 

Methods of increasing abiotic stress tolerance and/or biomass in plants


Provided are methods of increasing the tolerance of a plant to abiotic stresses and/or increasing the biomass and/or increasing the yield of a plant by expressing within the plant an exogenous polynucleotide encoding a polypeptide homologous to seq id no:240, such as the polynucleotide set forth by seq id no:14.. .
Evogene Ltd.


05/19/16
20160138034 

Novel genes involved in biosynthesis


The invention provides a novel myb class transcription factor gene (nucleic acid sequences, protein sequences, and variants and fragments thereof) designated myb14 by the applicants, that is useful for manipulating the production of flavonoids, specifically condensed tannins, in plants. The invention provides the isolated nucleic acid molecules encoding proteins with at least 70% identity to any one of myb14 polypeptide sequences of seq id no: 14 and 46 to 54.
Grasslanz Technology Limited


05/19/16
20160138023 

Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of brain derived neurotrophic factor (bdnp), in particular, by targeting natural antisense polynucleotides of brain derived neurotrophic factor (bdnf). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of bdnf..
Curna, Inc.




Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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