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Polynucleotide patents



      
           
This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
07/24/14
20140208458
 Plant having complex disease resistance patent thumbnailnew patent Plant having complex disease resistance
The present invention relates to plants that have been transformed so as to have both disease resistance and acceptable agronomic traits. More specifically, the present invention relates to transgenic plants that have acquired disease resistance through expression in the plants of a polynucleotide encoding the transcription factor wrky45 in an infection-responsive manner, and methods for generating the transgenic plants..
07/24/14
20140208457
 Nuclease fusion protein and uses thereof patent thumbnailnew patent Nuclease fusion protein and uses thereof
The present invention is concerned with nuclease fusion proteins and various uses thereof. Specifically, it relates to a polynucleotide encoding a polypeptide comprising (i) a first module comprising at least a first dna binding domain derived from a homing endonuclease, (ii) a linker, and (iii) a second module comprising at least a second dna binding domain and a cleavage domain derived from a restriction endonuclease, wherein said polypeptide functionally interacts only with dna comprising a dna recognition site for the first dna binding domain and a dna recognition site for the second dna binding domain, and wherein said cleavage domain cleaves dna within a specific dna cleavage site upon binding of the polypeptide.
07/24/14
20140206852
 Signal-sensor polynucleotides patent thumbnailnew patent Signal-sensor polynucleotides
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmrna molecules.. .
07/24/14
20140206755
 Modified polynucleotides for treating arylsulfatase a protein deficiency patent thumbnailnew patent Modified polynucleotides for treating arylsulfatase a protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/24/14
20140206594
 Polypeptides having protease activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having protease activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/24/14
20140206554
 Methods and systems for processing polynucleotides patent thumbnailnew patent Methods and systems for processing polynucleotides
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing..
07/24/14
20140206057
 Novel yeast strains patent thumbnailnew patent Novel yeast strains
There is provided an alkene-producing yeast cell comprising a bacterial fatty acid decarboxylase enzyme, which may comprise the amino acid sequence seq id no:1 or a functional variant or portion thereof. The alkene may have 15, 17 or 19 carbon atoms.
07/24/14
20140206035
 Polypeptides having glucoamylase activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having glucoamylase activity and polynucleotides encoding same
Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains..
07/24/14
20140206026
 Method for screening alpha-amylases patent thumbnailnew patent Method for screening alpha-amylases
The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
07/24/14
20140205652
 Novel method and compositions patent thumbnailnew patent Novel method and compositions
The present invention relates to, inter alia, a method of raising an immune response against a pathogen which comprises administering (i) one or more first immunogenic polypeptides derived from said pathogen; (ii) one or more adenoviral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from said pathogen; and (iii) an adjuvant; wherein the one or more first immunogenic polypeptides, the one or more adenoviral vectors and the adjuvant are administered concomitantly. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing said polypeptides, adenoviral vectors and adjuvants..
07/24/14
20140205604
new patent Antigen binding constructs
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain fc region of an antibody, wherein each epitope binding domain in capable of binding to vegf, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with vegf signalling, such as diabetic macular edema (dme), wet age-related macular degeneration (wet amd). Diabetic retinopathy, retinal vein occlusion (rvo), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs..
07/17/14
20140201871
Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/17/14
20140201864
Polynucleotides and polypeptides in plants
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
07/17/14
20140201861
Polynucleotides and polypeptides that confer increased yield, size or biomass
The present description relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant, including the traits of increased yield, size or biomass.. .
07/17/14
20140200264
Modified polynucleotides for treating carboxypeptidase n, polypeptide 1 protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140200263
Modified polynucleotides for treating galactosidase, alpha protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140200262
Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140200261
Signal-sensor polynucleotides for the alteration of cellular phenotypes
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140199762
Immunotherapeutic methods using epitopes of wt-1 and gata-1
A peptide comprising the amino acid sequence rmfpnapyl or a portion or variant thereof provided that the peptide is not intact human wt-1 polypeptide or a peptide comprising the amino acid sequence cmtwnqmnl or a portion or variant thereof provided that the peptide is not intact human wt-1 polypeptide or a peptide comprising the amino acid sequence hlmpfpgpll or a portion or variant thereof provided that the peptide is not intact human gata-1 polypeptide, and polynucleotides encoding these peptides. The peptides and polynucleotides are useful as cancer vaccines..
07/17/14
20140199760
Plants having enhanced abiotic stress resistance
Means are provided of increasing the growth potential and abiotic stress resistance in plants, characterized by expression of polynucleotides stably integrated into a plant genome or stably incorporated in the plant. Further provided are isolated nucleic acids and their stable inclusion in transgenic plants.
07/17/14
20140199705
Glucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-d-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-d-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-d-glucans or xyloglucans and other plant material containing cellulosic parts.
07/17/14
20140199691
Methods of fetal abnormality detection
Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided.
07/17/14
20140199688
Conditionallly replication-competent adenovirus
The present invention provides a polynucleotide, which comprises human telomerase reverse transcriptase (htert) promoter, e1a gene, ires sequence and e1b gene in this order and which comprises a target sequence of a first mirna. The present invention also provides a recombinant adenovirus, which comprises a replication cassette comprising the above polynucleotide, wherein the replication cassette is integrated into the e1 region of the adenovirus genome..
07/17/14
20140199371
Modified polynucleotides encoding basic helix-loop-helix family, member e41
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140199332
Method of treating cancer with an hla-a*3303-restricted wt1 peptide and pharmaceutical composition comprising the same
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a wt1 protein, wherein an amino acid residue at position 2 in the amino acid sequence is selected from the group consisting of ala, ile, leu, val, phe, tyr, ser and asp and an amino acid residue at position 9 in the amino acid sequence is arg; a polynucleotide encoding the peptide; a pharmaceutical composition comprising the peptide; and a method of treating cancer using the peptide.. .
07/10/14
20140196177
Acyl-coa: diacylglycerol acyltransferase 1-like gene (ptdgat1) and uses thereof
An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel acyl-coa: diacylglycerol acyltransferase 1—like gene (ptdgat1) from the diatom phaeodactylum tricomutum is provided together with a composition which includes the isolated protein and a transgenic organism transformed by a polynucleotide encoding same. The invention also provides a method for producing or enhancing the production of oil or triacylglycerols with high saturated fatty acids content..
07/10/14
20140196175
Axmi221z, axmi222z, axmi223z, axmi224z and axmi225z delta-endotoxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
07/10/14
20140196173
Plants having altered agronomic characteristics under nitrogen limiting conditions and related constructs and methods involving genes encoding lnt6 polypeptides and homologs thereof
Isolated polynucleotides and polypeptides and recombinant dna constructs particularly useful for altering agronomic characteristics of plants under nitrogen limiting conditions, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter functional in a plant, wherein said polynucleotide encodes an lnt6 polypeptide or homolog thereof..
07/10/14
20140196162
Plant transcriptional regulators
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having improved tolerance to drought, shade, and low nitrogen conditions, as compared to wild-type or reference plants.. .
07/10/14
20140194494
Modified polynucleotides for treating protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/10/14
20140194365
Use of endostatin peptides for the treatment of fibrosis
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and polynucleotides are disclosed.
07/10/14
20140194355
Isolated nucleic acid molecules encoding variant activin receptor polypeptides
The present invention provides variant activin iib soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin a, myostatin, or gdf-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins.
07/10/14
20140194351
Hemipteran-and coleopteran active toxin proteins from bacillus thuringiensis
A novel bacillus thuringiensis crystal protein exhibiting insect inhibitory activity is disclosed. Growth of lygus insects is significantly inhibited by providing the novel crystal protein in lygus insect diet.
07/10/14
20140194323
Multitag sequencing ecogenomics analysis-us
Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis.
07/10/14
20140194322
Methods for creating and identifying functional rna interference elements
The invention relates to the control of gene expression. Specifically, the invention provides compositions and methods for the production and use of recombinant nucleic acid molecules that have the ability to specifically downregulate an expressed target gene in vivo.
07/10/14
20140194312
Complex sets of mirnas as non-invasive biomarkers for dilated cardiomyopathy
The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of dilated cardiomyopathy in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of mirnas for diagnosing and/or prognosing of dilated cardiomyopathy in a body fluid sample from a subject.
07/10/14
20140193879
Dfpase enzymes from aplysia californica
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/10/14
20140193854
Method for mass-producing antifreeze protein derived from polar yeast
The present invention relates to a method for mass-producing an antifreeze protein derived from a polar yeast, and more particularly, to a method for mass-producing an antifreeze protein derived from leucosporidium sp., which is the polar yeast, for synthesizing a recombinant polynucleotide by optimizing and altering a gene, which codes the antifreeze protein derived from the polar yeast, for a yeast expression system, and for expressing same using the yeast expression system.. .
07/10/14
20140193822
Complex sets of mirnas as non-invasive biomarkers for kidney cancer
The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of mirnas for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject.
07/10/14
20140193821
Exonic splicing enhancers and exonic splicing silencers
Compounds and methods for regulation of exonic splicing enhancers and exonic splicing silencers. Compounds include polynucleotides targeted to aberrant exonic splicing enhancers and exonic splicing silencers.
07/10/14
20140193804
Biological specimen collection and transport system and method of use
Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay.
07/10/14
20140193482
Modified polynucleotides encoding v-myc avian myelocytomatosis viral oncogene homolog
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/10/14
20140193443
Method of treating cancer with an hla-a*3303-restricted wt1 peptide and pharmaceutical composition comprising the same
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a wt1 protein, wherein an amino acid residue at position 2 in the amino acid sequence is selected from the group consisting of ala, ile, leu, val, phe, tyr, ser and asp and an amino acid residue at position 9 in the amino acid sequence is arg; a polynucleotide encoding the peptide; a pharmaceutical composition comprising the peptide; and a method of treating cancer using the peptide.. .
07/10/14
20140193442
Method of treating cancer with an hla-a*3303-restricted wt1 peptide and pharmaceutical composition comprising the same
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a wt1 protein, wherein an amino acid residue at position 2 in the amino acid sequence is selected from the group consisting of ala, ile, leu, val, phe, tyr, ser and asp and an amino acid residue at position 9 in the amino acid sequence is arg; a polynucleotide encoding the peptide; a pharmaceutical composition comprising the peptide; and a method of treating cancer using the peptide.. .
07/10/14
20140193431
Anti-c-met antibody having hgf activity and use thereof
Disclosed are a human antibody comprising a human complementarity-determining region (cdr), which binds specifically to c-met, and a framework region (fr), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody b7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-met-specific human antibody can function as an hgf mimic that can be used as a wound healing composition.
07/03/14
20140189907
Transgenic cotton plants related to event 281-24-236 and to event 3006-210-23
This invention relates to plant breeding and the protection of plants from insects. More specifically, this invention includes novel transformation events of cotton plants comprising one or more polynucleotide sequences, as described herein, inserted into specific site(s) within the genome of a cotton cell..
07/03/14
20140189902
Compositions associated with soybean iron deficiency tolerance and methods of use
Molecular markers useful for identifying, selecting, and/or providing soybean plants displaying tolerance, improved tolerance, or susceptibility to iron deficiency, methods of their use, and compositions having one or more marker loci are provided. Methods comprise detecting at least one marker locus, detecting a haplotype, and/or detecting a marker profile.
07/03/14
20140187615
Therapeutic polynucleotides, compositions, and methods
This disclosure describes, in one aspect, a composition that generally includes an xna molecule comprising at least six nucleotides, in an amount effective to improve at least one indicator of myocyte function and a pharmaceutically acceptable carrier. In another aspect, this disclosure describes a method of treating cardiac disease.
07/03/14
20140187606
Treatment of frataxin (fxn) related diseases by inhibition of natural antisense transcript to fxn
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of frataxin (fxn), in particular, by targeting natural antisense polynucleotides of frataxin (fxn). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of fxn..
07/03/14
20140187438
Methods and compositions for the diagnosis and treatment of epithelial cancers
Methods for detecting, diagnosing and monitoring an epithelial cancer in a patient are described comprising measuring in a sample from the patient ep-icd polypeptides and ep-icd polynucleotides. Methods for prognosis of breast cancer comprising measurement of nuclear ep-icd polypeptides and optionally epex polypeptides are provided.
07/03/14
20140187429
Apparatus and method for specific release of captured extension products
Apparatus and methods for separating different polynucleotide populations in a mixture are provided, wherein different polynucleotides or polynucleotide populations are captured on different solid support. After hybridization, polynucleotides are selectively released from a selected support by altering a physical property of that support.
07/03/14
20140186942
Methods for genomic modification
Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more integration polynucleotides comprising an exogenous nucleic acid to be integrated into a genomic target site, and a nuclease capable of causing a double-strand break near or within the genomic target site..
07/03/14
20140186924
Methods for transforming tarwi and for producing molecular farming products in transgenic tarwi seed
The present disclosure describes reproducible methods for the agrobacterium-mediated production of stable, genetically transformed, fertile tarwi plants (lupinus mutabilis sweet) having seed-specific expression of human adenosine deaminase enzyme (hada) or a functional variant thereof. The method involves slicing a tarwi seed embryo to produce an explant; infecting the explant in co-cultivation medium containing an agrobacterium having a polynucleotide sequence encoding hada or variant; thereby generating a transformed explant; elongating a transformed shoot from the transformed explant; and regenerating a transformed tarwi plant from the elongated shoot.
07/03/14
20140186906
Recombinant microbial cells that produce at least 28% eicosapentaenoic acid as dry cell weight
Recombinant microbial cells are disclosed herein that produce an oil comprising at least 28 percent eicosapentaenoic acid (epa) measured as a weight percent of dry cell weight. These cells may comprise a polynucleotide sequence encoding an active acyl-coa:lysophosphatidylcholine acyltransferase (lpcat) comprising at least one amino acid mutation in a membrane-bound o-acyltransferase motif.
07/03/14
20140186891
Polynucleotides encoding il-31 monoclonal antibodies
The invention provides humanized mouse anti-human il-31 antibodies and antibody fragments that are capable of binding il-31 and thereby neutralizing, inhibiting, limiting, or reducing the proinflammatory or pro-pruritic effects of il-31.. .
07/03/14
20140186844
Polynucleotide primers and probes
The present disclosure provides a novel technology that involves improved primer design. These primer pairs have a wide range of applications and provide high sensitivity and specificity..
07/03/14
20140186821
Noninterfering multipurpose compositions for collecting, transporting and storing biological samples
The invention is directed to compositions and methods for collecting, transporting, and storing microorganisms obtained from samples of biological, clinical, forensic, and environmental origin. Compositions preserve the viability of the collected organisms, permit long-term storage, and are compatible with subsequent manipulation including propagation and culture of collected microorganisms, or isolation, purification, detection, and characterization of proteins, nucleic acids and macromolecules.
07/03/14
20140186494
Pregastric esterase and derivatives thereof
The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms..
07/03/14
20140186432
Modified polynucleotides encoding cited4
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/03/14
20140186382
Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
The invention is related to polynucleotide-based cytomegalovirus vaccines. In particular, the invention is plasmids operably encoding hcmv antigens, in which the naturally-occurring coding regions for the hcmv antigens have been modified for improved translation in human or other mammalian cells through codon optimization.
07/03/14
20140186379
Novel macromolecule transduction domains and methods for identification and uses thereof
The present invention discloses novel macromolecule transduction domain (mtd) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the mtd peptides, methods of identifying the mtd peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the mtd peptides, methods of importing a biologically active molecule into a cell by using the mtd peptides, and uses thereof..
07/03/14
20140186334
Surface, anchored fc-bait antibody display system
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell.
06/26/14
20140182014
Isolated eif-5a and polynucleotides encoding same
The present invention relates to unique isoforms of eukaryotic initiation factor 5a (“eif-5a”): senescence-induced eif-5a; wounding-induced eif-5a; and growth eif-5a, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors.
06/26/14
20140179940
Methods and compositions for improved production of fatty acids and derivatives thereof
The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-coa, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadr.. .
06/26/14
20140179771
Modified polynucleotides for treating dolichyl-phosphate (udp-n-acetylglucosamine) n-acetylglucosaminephosphotransferase 1 (glcnac-1-p transferase) protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
06/26/14
20140179588
Polypeptides having cellulase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
06/26/14
20140179558
Method for detecting pancreatic cancer
This invention relates to a method for detecting pancreatic cancer using novel tumor markers. Specifically, the invention provides a method for detecting pancreatic cancer comprising measuring the presence or an amount of a polypeptide having an reactivity of binding via an antigen-antibody reaction to an antibody against caprin-1 protein in a sample separated from a subject, and to a reagent or kit for detecting pancreatic cancer comprising a caprin-1 protein or a fragment thereof, an antibody against the same, or a polynucleotide encoding the same..
06/26/14
20140179539
Novel ligase activity
Compositions and methods are provided for ligating polynucleotides having a length that is greater than 8 nucleotides on an rna splint. The ligation reaction provides consistent results in high or low atp concentrations.
06/26/14
20140178931
Mtor ligands and polynucleotides encoding mtor ligands
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mtor activity.
06/26/14
20140178885
Composition and kit for diagnosing breast cancer including polynucleotide within vesicle, and method of diagnosing breast cancer using the same
A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microrna (mirna) selected from the group consisting of hsa-mir-126, hsa-mir-23a, hsa-mir-24, hsa-mir-19b, hsa-mir-103, hsa-mir-142-3p, hsa-mir-144, hsa-mir-15a, hsa-mir-185, hsa-mir-93, and hsa-mir-30c in a vesicle, or a fragment of the microrna..
06/26/14
20140178881
Methods for detection of nucleotide modification
This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mc), 5-hydroxymethylcytosine (5hmc) and 5-formylcytosine (5fc) to be distinguished from cytosine (c) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence.
06/26/14
20140178856
Polynucleotide derived from novel hepatitis c virus strain and use thereof
A polynucleotide encoding the amino acid shown in seq id no:2 or seq id no: 5, or encoding an amino acid sequence having not less than 98% identity thereto; preferably a polynucleotide comprising replacement of the amino acid corresponding to glutamic acid at position 1202 of seq id no:2 (position 177 of seq id no:5) with glycine, replacement of the amino acid corresponding to glutamic acid at position 1056 (position 31 of seq id no:5) with valine, and replacement of the amino acid corresponding to alanine at position 2199 (position 1174 of seq id no:5) with threonine.. .
06/26/14
20140178460
Lyase enzymes, nucleic acids encoding them and methods for making and using them
This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
06/26/14
20140178423
Novel compositions and methods
The present invention is directed to a polypeptide which comprises: (i) an rv2386c protein sequence; (ii) a variant of an rv2386c protein sequence; or (iii) an immunogenic fragment of an rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis..
06/26/14
20140178409
Sema5b peptides and vaccines including the same
As discussed in detail herein, isolated epitope peptides derived from sema5b bind to an hla antigen and induce cytotoxic t lymphocytes (ctl) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines. The inventive peptides encompass both the above mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite hla binding and/or ctl inducibility of the original sequences.
06/26/14
20140178345
Thymidine kinase
A polynucleotide comprising a nucleotide sequence encoding a thymidine kinase wherein at least one of the nucleotides corresponding to the splice donor site nucleotides is replaced by another nucleotide and wherein the nucleotides of the splice acceptor sites are not altered.. .
06/26/14
20140178333
Homogenous preparations of il-28 and il-29
Homogeneous preparations of il-28a, il-28b, and il-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity.


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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