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This page is updated frequently with new Polynucleotide-related patent applications. Subscribe to the Polynucleotide RSS feed to automatically get the update: related Polynucleotide RSS feeds. RSS updates for this page: Polynucleotide RSS RSS


Date/App# patent app List of recent Polynucleotide-related patents
05/21/15
20150143588
 Universal donor system for gene targeting patent thumbnailnew patent Universal donor system for gene targeting
A universal donor polynucleotide is described that can be inserted at targeted locations in plant genomes to facilitate rapid and high throughput integration of a donor molecule within a specific genomic location.. .
Dow Agrosciences Llc
05/21/15
20150143583
 Use of the soybean sucrose synthase promoter to increase plant seed lipid content patent thumbnailnew patent Use of the soybean sucrose synthase promoter to increase plant seed lipid content
Recombinant dna constructs comprising the soybean sucrose synthase promoter operably linked to polynucleotides encoding transcription factors such as odp1, lec1 and fusca3 are disclosed. These constructs are used for increasing oil content while maintaining normal germination in oilseed plants.
Pioneer Hi-bred International Inc
05/21/15
20150143581
 Nucleic acid molecules and other molecules associated with plants and uses thereof patent thumbnailnew patent Nucleic acid molecules and other molecules associated with plants and uses thereof
Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
Monsanto Technology Llc
05/21/15
20150143580
 Compositions and methods for controlling leptinotarsa patent thumbnailnew patent Compositions and methods for controlling leptinotarsa
Disclosed herein are methods of controlling insect pests, in particular leptinotarsa spp. Which infest crop plants, and methods of providing plants resistant to such pests.
Monsanto Technology Llc
05/21/15
20150143579
 Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics patent thumbnailnew patent Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased tolerance to abiotic stress (e.g., high or low temperature, drought, flood).. .
Ceres, Inc.
05/21/15
20150143556
 Mutant alpha-synuclein, and methods using same patent thumbnailnew patent Mutant alpha-synuclein, and methods using same
The present invention relates to a mutant human alpha-synuclein with increased toxicity compared to wild-type alpha-synuclein, or a homologue thereof, wherein the mutant alpha-synuclein or homologue thereof comprises at least one amino acid substitution selected from the group consisting of a substitution at the alanine at position 56 (a56), at the alanine at position 76 (a76), at the methionine at position 127 (m127) and/or at the valine at position 118 (v118), as defined in the claims. Further, the invention relates to a polynucleotide encoding the mutant alpha-synuclein or homologue thereof, or an expression vector comprising said polynucleotide, a cell comprising the polynucleotide or expression vector, as defined in the claims.
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
05/21/15
20150141622
 Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy patent thumbnailnew patent Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy
The present invention provide purified flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.. .
Vegenics Limited
05/21/15
20150141494
 Treatement of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf patent thumbnailnew patent Treatement of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
Oligonucleotide compounds modulate expression and/or function of vascular endothelial growth factor (vegf) polynucleotides and encoded products thereof. Methods for treating diseases associated with vascular endothelial growth factor (vegf) comprise administering one or more oligonucleotide compounds designed to inhibit the vegf natural antisense transcript to patients..
Curna, Inc.
05/21/15
20150141331
 Long-acting polypeptides and methods of producing and administering same patent thumbnailnew patent Long-acting polypeptides and methods of producing and administering same
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed..
Opko Biologics Ltd.
05/21/15
20150141285
 Detection of unlabeled nucleic acids by changing solubility of surface-associating probes patent thumbnailnew patent Detection of unlabeled nucleic acids by changing solubility of surface-associating probes
Provided are methods and devices for detection of unlabeled nucleic acids. The detection methods are based on change of solubility of hydrophobic probes upon hybridization with a polynucleotide.
New York University
05/21/15
20150140665
new patent

Site-specific integration of transgenes into human cells


Methods for inserting a polynucleotide sequence into the genome of a human cell are provided. The present methods result in insertion of a polynucleotide sequence of interest into the h11 locus in the genome of a human cell.
The Board Of Trustees Of The Leland Stanford Junior University
05/21/15
20150140638
new patent

Polypeptides having endoglucanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.
05/21/15
20150140636
new patent

Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression


The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.. .
Promega Corporation
05/21/15
20150140620
new patent

Biosynthetic pathways, recombinant cells, and methods


This disclosure describes engineered biosynthetic pathways, recombinant cells, and methods relating to biosynthesis of esters. The recombinant cells may be modified to exhibit increased biosynthesis of an ester compared to a wild-type control.
Regents Of The University Of Minnesota
05/21/15
20150140614
new patent

Variants of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase


The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.. .
Evonik Degussa Gmbh
05/21/15
20150140588
new patent

Lipase variants and polynucleotides encoding same


The present invention relates to variants with improved activity in an amide-bond reaction. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s
05/21/15
20150140574
new patent

Method for producing horseradish peroxidase recombinant protein using filamentous fungus


A modified polynucleotide has a different base sequence in at least one codon from a wild-type base sequence encoding a horseradish peroxidase polypeptide. The usage frequency of the modified codon of the polynucleotide corresponds to the codon usage frequencies of three filamentous fungal species in humicola, aspergillus, and trichoderma.
Meiji Seika Pharma Co., Ltd.
05/21/15
20150140547
new patent

Methods and compositions for assessing copy number of target polynecleotides


The present invention relates to methods and compositions for assessing copy number of a target polynucleotide in a sample, methods and compositions for establishing a standard curve for a target polynucleotide, and the uses of the methods and compositions for detecting a pathogen, e.g., human papillomavirus (hpv).. .
Ningbo Health Gene Technology Co., Ltd.
05/21/15
20150139993
new patent

Hemojuvelin fusion proteins and uses thereof


The present invention provides a hemojuvelin (hjv) fusion protein (e.g., a human hjv.fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a hjv fusion protein to a patient in need thereof..
The General Hospital Corporation
05/14/15
20150135366

Isopentenyl transferase sequences and methods of use


Methods and compositions for modulating plant development are provided. polynucleotide sequences and amino acid sequences encoding isopentenyl transferase (ipt) polypeptides are provided.
05/14/15
20150135364

Method and materials for making plants heat-resistant


The invention pertains to a method for generating a heat-resistant plant, including the step of introducing a polynucleotide, having a first sequence portion for transcriptionally driving a second sequence portion that is operably linked to a second sequence portion encoding for a mirna156 family member into a plant cell, wherein the first sequence portion is heat-stress inducible.. .
05/14/15
20150135362

Plant regulatory elements and uses thereof


The invention provides dna molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and plant cells. Transgenic plants, plant cells, plant parts, seeds, and commodity products comprising the dna molecules operably linked to heterologous transcribable polynucleotides are also provided, as are methods of their use..
05/14/15
20150135360

Stress tolerance in plants


Transcription factor polynucleotides and polypeptides incorporated into nucleic acid constructs, including expression vectors, have been introduced into plants and were ectopically expressed. Transgenic plants transformed with many of these constructs have been shown to be more resistant to disease (in some cases, to more than one pathogen), or more tolerant to an abiotic stress (in some cases, to more than one abiotic stress).
05/14/15
20150133526

Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of discs large homolog (dlg), in particular, by targeting natural antisense polynucleotides of discs large homolog (dlg). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorder associated with the expression of dlg..
05/14/15
20150133379

Cosmetic composition for improving skin conditions comprising fusion protein


The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a transformant comprising the expression vector, a method for preparing the fusion protein, a cosmetic composition for improving skin conditions, which comprises the fusion protein, and a pharmaceutical composition for external skin use, which comprises the fusion protein. The fusion protein of the invention comprises a skin-penetrating peptide bound to a physiologically active protein.
05/14/15
20150133345

Fluorescence detector for microfluidic diagnostic system


The present technology provides for a fluorescent detector that is configured to detect light emitted for a probe characteristic of a polynucleotide. The polynucleotide is undergoing amplification in a microfluidic channel with which the detector is in optical communication.
05/14/15
20150133317

Identification of polynucleotides associated with a sample


Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample.
05/14/15
20150132824

Polypeptides having xanthan degrading activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xanthan degrading activity, catalytic domains and polynucleotides encoding the polypeptides and catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and catalytic domains..
05/14/15
20150132822

Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
05/14/15
20150132807

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds


The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.. .
05/14/15
20150132806

Ketoreductase polypeptides


The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4s)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4s)-3-[(5s)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4s)-3-[(5s)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making ezetimibe..
05/14/15
20150132770

Pregnancy-associated plasma protein-a2 (papp-a2) polynucleotides


The present invention provides pregnancy associated plasma protein a2 (papp-a2), its nucleotide and amino acid sequences, antisense molecules to the nucleotide sequences which encode papp-a2, expression vectors for the production of purified papp-a2, antibodies capable of binding specifically to papp-a2, hybridization probes or oligonucleotides for the detection of papp-a2-encoding nucleotide sequences, genetically engineered host cells for the expression of papp-a2, and methods for screening for pathologies in pregnant and non-pregnant patients. Methods for screening for altered focal proliferation states in pregnant and/or non-pregnant patients, which include detecting levels of papp-a2, are also described..
05/14/15
20150132754

Method for increasing accuracy in quantitative detection of polynucleotides


Disclosed is a method for improving the sensitivity and accuracy of quantitative detection of polynucleotides in a sample, such a clinical specimen, by a method that utilizes a two- or three-step process of tagging/labeling target molecules and adding an adapter sequence for adding a universal primer for efficient amplification of targets while decreasing target amplification bias. When combined with the step of statistically correcting for sequencing errors, the method can significantly increase the accuracy of quantitative detection of polynucleotides in a sample..
05/14/15
20150132383

Phytases, nucleic acids encoding them and methods for making and using them


This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures.
05/14/15
20150132332

Anti-hiv vaccine constructed based on amino acid mutations in attenuated live eiav vaccine


Provided are antigenic polypeptides of hiv envelope glycoproteins which are constructed based on amino acid mutation of attenuated live vaccine of equine infectious anemia virus, dna constructions and recombinant virus vectors comprising polynucleotides encoding said polypeptides, antibodies against said polypeptides as well as uses thereof in preventing and treating hiv infection. Said antigenic polypeptides and vaccines can induce high titer neutralization antibodies against hiv in organism..
05/14/15
20150132293

Immunostimulatory sequence oligonucleotides and methods of using the same


The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.. .
05/14/15
20150132277

Monomeric forms of human aminoacyl-trna synthetases having non-canonical biological activities


Isolated monomeric aminoacyl-trna synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.. .
05/14/15
20150132265

Methods and compositions for treating disease


The present invention relates to methods and compositions for treating a subject comprising destroying diseased cells in the subject. The methods comprise obtaining a population of cells from a subject and determining the activity of at least one disease marker gene within the population of the obtained cells.
05/14/15
20150132224

Antibodies to il-6 and use thereof


The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for il-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the vh, vl and cdr polypeptides described herein, and the polynucleotides encoding them.
05/14/15
20150129761

Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy


The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion.. .
05/07/15
20150128305

Polynucleotide encoding catlp1 protein and uses thereof


The present invention provides herein a polynucleotide sequence encoding the tubby-like protein, catlp1, from chickpea (cicer arientium l.) that is responsive to abiotic stress and is involved in plant growth and development. Further, the recombinant dna construct and recombinant vector comprising the polynucleotide sequence encoding catlp1, host cell comprising the recombinant vector and a process for producing a transgenic plant that expresses the catlp1 protein are also provided herein..
National Institute Of Plant Genome Research
05/07/15
20150126587

Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of tumor protein 63 (p63), in particular, by targeting natural antisense polynucleotides of tumor protein 63 (p63). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of p63..
Curna, Inc.
05/07/15
20150126461

Skin-permeating peptide


The present invention relates to a skin-permeating peptide, and more particularly, the present invention relates to an isolated peptide capable of permeating the skin to deliver a drug to the skin, to an isolated polynucleotide coding the peptide, to a composition for transdermal delivery comprising the peptide, and to a peptide/cargo composite comprising the peptide and cargo.. .
Lg Household & Health Care, Ltd.
05/07/15
20150126445

Long-acting polypeptides and methods of producing and administering same


A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed..
Opko Biologics Ltd.
05/07/15
20150125951

Mutant alpha-synuclein, and methods using same


The present invention relates to a mutant human alpha-synuclein with increased toxicity compared to wild-type alpha-synuclein, or a homologue thereof, wherein the mutant alpha-synuclein or homologue thereof comprises at least one amino acid substitution selected from the group consisting of a substitution at the alanine at position 56 (a56), at the alanine at position 76 (a76), at the methionine at position 127 (m127) and/or at the valine at position 118 (v118), as defined in the claims. Further, the invention relates to a polynucleotide encoding the mutant alpha-synuclein or homologue thereof, or an expression vector comprising said polynucleotide, a cell comprising the polynucleotide or expression vector, as defined in the claims.
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
05/07/15
20150125933

Production of fatty acids and derivatives thereof having improved aliphatic chain length and saturation characteristics


The invention relates to compositions, including polynucleotide sequences, amino acid sequences, recombinant microorganisms, and recombinant microorganism cultures that produce compositions of fatty acids and derivatives having target aliphatic chain lengths and/or preferred percent saturation. Further, the invention relates to methods of making and using the compositions.
Ls9, Inc.
05/07/15
20150125910

Ketoreductase polypeptides for the production of (r)-3-hydroxythiolane


The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds..
Codexis, Inc.
05/07/15
20150125902

Polypeptides having glucoamylase activity and polynucleotides encoding same


Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains..
Novozymes A/s
05/07/15
20150125458

Anti-ccl17 antibodies


The present invention relates to antibodies specifically binding ccl17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.. .
Janssen Biotech, Inc.
05/07/15
20150125433

Methods and compositions for the treatment of insulin-associated medical conditions


A method of increasing insulin content in a pancreatic beta cell is disclosed. The method comprising expressing in the pancreatic beta cell an exogenous polynucleotide encoding at least one microrna or a precursor thereof, wherein the microrna is selected from the group consisting of mir-15, mir-16, mir-24, mir-26, mir-27, mir-29, mir-30, mir-129, mir-141, mir-148, mir-182, mir-200, mir-376 and let-7, thereby increasing the insulin content in the pancreatic beta cell..
Yeda Research And Development Co. Ltd.
05/07/15
20150125424

Bacteriophage for biocontrol of salmonella and in the manufacturing or processing of foods


The invention relates to the field of microbiology, specifically to a bacteriophage, polypeptide and a corresponding polynucleotide, a nucleic acid molecule and/or vector and/or cell comprising such polynucleotide, a composition comprising said bacteriophage, polypeptide, polynucleotide, construct, vector and/or cell, preferably for preventing, treating or diagnosing contamination with and/or a condition in an individual related to salmonella. The invention further relates to an antimicrobial composition for medical use or for use as a food additive or as a disinfectant, or for detecting bacteria, preferably in a diagnostic application, wherein said antimicrobial composition comprises a bacteriophage, polypeptide, corresponding polynucleotide, construct and/or vector and/or cell comprising such polypeptide and/or composition according to the present invention..
Micreos B.v.
04/30/15
20150121573

Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same


Nucleic acid constructs are provided. These constructs comprise any of the, nucleic acid sequences at least 85% identical to nucleotide sequences selected from the group consisting of seq id nos: 68, 1, 4, 5, 8, 9, 11, 13, 16, 19, 20, 23, 24, 27, 30, 32, 37, 42, 49, 50, 51, 53, 54, 55, 56, 57, 58, 64, 69, 70, 73, 77, 78, 79, 80, 84, 86, 87, 93, 94, 98, 101, 102, 103, 104, 105, 106, 107, 108 and 109 and a promoter sequence capable of directing transcription of said nucleic acid sequence in a host cell.
Evogene Ltd.
04/30/15
20150120265

System for polynucleotide construct design, visualization and transactions to manufacture the same


The present invention disclose a computerized system for designing nucleic acid sequences for gene expression comprising; (a) a server [103] for hosting a database [106] (b) a network connection [102] and (c) a computer readable medium [101] comprising functional modules including (i) a design module for enabling designing of nucleic acid constructs; (ii) interactive user interface module for visualizing biological information relating to design operations; (iii) transaction module for purchasing a user-designed or pre-stocked nucleic acid constructs (iv) a detecting module for detecting designed nucleic acid sequences comprises harmful sequences; the system is operating in a method of: (a) visualizing biological information; (b) designing nucleic acid sequences; (c) detecting and notifying when harmful sequences are designed; (d) providing means for transactions regarding ordering and purchasing said synthesized nucleic acids.. .
Genome Compiler Corporation
04/30/15
20150119451

Treatment of interferon regulatory factor 8 (irf8) related diseases by inhibition of natural antisense transcript to irf8


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of interferon regulatory factor 8 (irf8), in particular, by targeting natural antisense polynucleotides of interferon regulatory factor 8 (irf8). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of irf8..
Curna, Inc.
04/30/15
20150119450

Compositions for use in treating or diagnosing bone disorders and/or cardiovascular disorders


Compositions of an inhibitor of a polynucleotide for use in treating or preventing bone disorders such as osteoporosis, osteopenia, bone fracture, bone cancer, as well as impaired bone homeostasis. Preferred compounds to be used in these medical interventions are antagonistic compounds, like nucleic acid molecules, directed against mir-31 and derivatives thereof.
Universitat Fur Bodenkultur Wien
04/30/15
20150119403

Mutant ros expression in human cancer


The invention provides the identification of the presence of mutant ros protein in human cancer. In some embodiments, the mutant ros are fig-ros fusion proteins comprising part of the fig protein fused to the kinase domain of the ros kinase.
Cell Signaling Technology, Inc.
04/30/15
20150119343

Production of tsg-6 protein


A method of producing a protein or polypeptide, such as, for example, tsg-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells.
The Texas A & M University System
04/30/15
20150119325

Methods for the production of cytoprotective asialo-erythropoietin in plants and its purification from plant tissues


The present invention provides methods for the high-level production of recombinant human erythropoietin (rhuepo) derivative, asialoerythropoietin (asialo-rhuepo), in plants. The methods for producing asialo-rhuepo comprise making a plant or at least one plant cell that comprises a promoter that drives expression in a plant cell operably linked to a polynucleotide encoding a human erythropoieting fusion protein and a promoter that drives expression in a plant cell operably linked to a polynucleotide encoding n-glycosylation modification enzyme, particularly a mammalian β1,4-galactosyltransferase.
North Carolina Central University
04/30/15
20150119293

Synthetic ligation reassembly in directed evolution


A directed evolution process for rapid and facilitated production from a progenitor polynucleotide template, of a library of mutagenized progeny polynucleotides wherein each of the 20 naturally encoded amino acids is encoded at each original codon position. This method, termed site-saturation mutagenesis, or simply saturation mutagenesis, is preferably based on the use of the degenerate n,n,g/t sequence.
Bp Corporation North America Inc.
04/30/15
20150119292

Method for retaining even coverage of short insert libraries


The invention relates to a method of preparing a library of template polynucleotides with uniform sequence representation and to use of a library of templates prepared using this method for solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends, which contains even representation of all the fragments present in a starting sample of nucleic acid before fragmentation.
Illumina Cambridge Limited
04/30/15
20150119291

Nucleic acid amplification


The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mrna, using oligonucleotides, dna and rna polymerases are provided.
Life Technologies Corporation
04/30/15
20150118754

Stable expression system for eukaryotic cells


The present invention related to a polynucleotide sequence and an expression vector comprising at least one gene encoding a stress resistance protein, at least one gene encoding a selection marker, at least one gene encoding an expression protein, at least one matrix attachment region and a transcription terminator, all of which are operably connected to each other. The present invention further relates to a host cell comprising the expression vector.
Biogenomics Limited
04/30/15
20150118732

Genetically stable live attenuated respiratory syncytial virus vaccine and its production


Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability.
The United States Of America, As Rep. By The Sec. Dept. Of Health And Human Services
04/30/15
20150118719

Biocatalysts and methods for hydroxylation of chemical compounds


The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts.
Codexis, Inc.
04/30/15
20150118684

Method for processing polynucleotide-containing samples


Methods and systems for processing polynucleotides (e.g., dna) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and ph) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic ph).
Handylab, Inc.
04/30/15
20150118262

Haemophilus influenzae type iv pili


The invention described herein relates to a haemophilus influenzae (h. Influenzae) regulon encoding type iv pili.
Nationwide Children's Hospital, Inc.
04/30/15
20150118241

Lingo-2 antagonists for treatment of conditions involving motor neurons


The invention provides methods of treating diseases, disorders or injuries involving motor neuron survival and axonal growth, including amylotrophic lateral sclerosis, by the administration of a lingo-2 antagonist. An exemplary method for promoting survival of a motor neuron, comprising contacting said motor neuron with an effective amount of a composition comprising a lingo-2 antagonist selected from the group consisting of: (i) a soluble lingo-2 polypeptide; (ii) a lingo-2 antibody or antigen-binding fragment thereof; (iii) a lingo-2 antagonist polynucleotide; (iv) a lingo-2 aptamer; and (v) a combination of two or more of said lingo-2 antagonists..
Biogen Idec Ma Inc.
04/30/15
20150118185

Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same


Compositions containing conjugates of heparosan polymer with at least one drug are disclosed, along with methods of production and use thereof.. .
The Board Of Regents Of The University Of Oklahoma
04/23/15
20150113668

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same


The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides..
Omt, Inc.
04/23/15
20150111957

Endothelial cell-specific polynucleotides and use thereof


An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of hif-1alpha, the polypeptide being stably expressed and constitutively active. Isolated polypeptides encoded by same are also disclosed and uses thereof..
Vascular Biogenics Ltd.
04/23/15
20150111955

Aav vector compositions and methods for gene transfer to cells, organs and tissues


The invention relates to adeno-associated virus (aav) serotype aav-rh74 and related aav vectors, and aav-rh74 and related aav vector mediated gene transfer methods and uses. In particular, aav-rh74 targets polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences..
The Children's Hospital Of Philadelphia
04/23/15
20150111282

Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same


Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as seq id no: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.. .
Mogam Biotechnology Research Institute
04/23/15
20150111268

Enzyme used in biosynthesis of 1, 4-bdo and screening the same


Recombinant butyraldehyde dehydrogenases (blds) with improved production of 1,4-bdo, as well as recombinant microorganisms comprising polynucleotides encoding the recombinant blds, and methods of producing 1,4-bdo by using the recombinant microorganisms.. .
Ajou University Industry-academic Cooperation Foundation
04/23/15
20150111260

Aldolases, nucleic acids encoding them and methods for making and using them


This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, hmg and/or khg aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, hmg and/or khg aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
Cargill, Incorporated
04/23/15
20150111248

In vivo production of proteins


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.
04/23/15
20150111197

Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof


The present invention concerns wild-strains of chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions..
Institut Pasteur


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Polynucleotide topics: Nucleotide, Polynucleotide, Polypeptide, Antagonist, Nucleic Acid, Cancer Cell, Drug Resistance, Chromosome, Glycoprotein, Gastrointestinal, Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Tumor, Cellobiohydrolase, Human Disease, Inflammation

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