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Polymerase

Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Qualitative and quantitative detection of microbial nucleic acids
Roche Molecular Systems, Inc.
October 12, 2017 - N°20170292145

The present invention relates to new methods and uses for the qualitative and quantitative detection of microbial nucleic acids using at least a first control nucleic acid, or a first and a second control nucleic acid in different concentrations. The method is based on amplification of nucleic acids, for example the polymerase chain reaction. Further provided are kits comprising components ...
Compositions, methods, and kits for synthesis and detection of nucleic acids
Life Technologies Corporation
October 12, 2017 - N°20170292144

Compositions, methods, and kits for synthesizing, detecting, and/or quantifying nucleic acids are provided herein. Embodiments comprise a nucleic acid amplification composition comprising a thermostable dna polymerase and agents which improve nucleic acid synthesis, amplification, detection, and/or quantification of nucleic acid targets in a crude extract or crude lysate sample.
Rna polymerase i inhibitors and uses thereof
Tel Hashomer Medical Research Infrastructure And Services, Ltd.
October 12, 2017 - N°20170290842

Provided are novel compounds which are capable of inhibiting an activity of rna polymerase i, and uses thereof in treating diseases or disorders modulated by rna polymerase i, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.
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Methods and apparatus for single molecule sequencing using energy transfer detection
Life Technologies Corporation
October 05, 2017 - N°20170283868

Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide ...
Microfluidic siphoning array for nucleic acid quantification
Combinati, Inc.
October 05, 2017 - N°20170283855

A microfluidic device can have a plurality of microchambers connected to a microchannel via siphon apertures. The microfluidic device may be formed from a thermoplastic and capped by a thermoplastic thin film. The microfluidic device may be used for digital polymerase chain reactions by forcing reagent into the microchambers at low pressure via an inlet, forcing any gas trapped in ...
Compositions and methods relating to synthetic rna polynucleotides created from synthetic dna oligonucleotides
New England Biolabs, Inc.
October 05, 2017 - N°20170283797

Compositions and methods are provided for forming a single rna polynucleotide from a plurality of dna oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. Dna polymerase, rna polymerase and single stranded (ss) dna oligonucleotides are combined where each dna oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss ...
Polymerase Patent Pack
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Polymerase Patent Applications
Download 270+ Polymerase-related PDFs
For professional research & prior art discovery
inventor
  • 270+ full patent PDF documents of Polymerase-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Nucleic acid amplification reaction method, nucleic acid amplification reaction apparatus, and nucleic acid amplification reaction ...
Seiko Epson Corporation
September 28, 2017 - N°20170275682

A nucleic acid amplification reaction method includes subjecting a reaction mixture containing a nucleic acid amplification reaction reagent to be used for amplifying a nucleic acid to a thermal cycle for amplifying the nucleic acid, wherein in the thermal cycle, a heating time for an annealing reaction and an elongation reaction is 1 sec or more and 10 sec or less, the ...
Polymerases
Illumina Cambridge Limited
September 28, 2017 - N°20170275602

Modified dna polymerases have an affinity for dna such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate dna templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-dna complexes in each reaction cycle. The modified polymerases may be used in a number of dna ...
Inhibitors of hepatitis c virus polymerase
Cocrystal Discovery, Inc.
September 28, 2017 - N°20170273962

The present invention provides, among other things, compounds represented by the general formula i: and pharmaceutically acceptable salts thereof, wherein x, y, r2, and r3 are as defined in classes and subclasses herein and compositions (e. G., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis c virus polymerase, and thus are useful, for example, as ...
Ph measurement for sequencing of dna
The Board Of Trustees Of The Leland Stanford Junior University
September 21, 2017 - N°20170268053

The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a complementary base (dntp) in the presence of appropriate reagents (dna polymerase, and ...
Polymerase-template complexes
Genia Technologies, Inc.
September 21, 2017 - N°20170268052

The present disclosure provides methods and compositions for enhancing the processivity of a polymerase in catalyzing template-dependent dna synthesis in high concentrations of salt. Also disclosed are methods and compositions for enhancing the assembly of polymerase-template complex compatible with active dna synthesis in the presence of low levels of nucleotides and at a high temperature, such as temperatures at or ...
Nucleic acid detection method
Kabushiki Kaisha Toshiba
September 21, 2017 - N°20170268049

The nucleic acid detection method includes maintaining a reaction liquid containing the sample, a marker substance, polymerase, a primer set, and salt of a predetermined concentration in the reaction field which include a substrate and a probe, under an amplification condition, detecting a signal from the marker substance and determining existence and/or quantity of the target nucleic acid. The ...
Exonuclease deficient polymerases
Genia Technologies, Inc.
September 21, 2017 - N°20170267983

Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have ...
Polymerase Patent Pack
Download 270+ patent application PDFs
Polymerase Patent Applications
Download 270+ Polymerase-related PDFs
For professional research & prior art discovery
inventor
  • 270+ full patent PDF documents of Polymerase-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Antiviral azasugar-containing nucleosides
Biocryst Pharmaceuticals, Inc.
September 21, 2017 - N°20170267681

Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral rna polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are ...
Integrated on chip detector and zero waveguide module structure for use in dna sequencing
International Business Machines Corporation
September 14, 2017 - N°20170263801

A semiconductor structure for use in single molecule real time dna sequencing technology is provided. The structure includes a semiconductor substrate including a first region and an adjoining second region. A photodetector is present in the first region and a plurality of semiconductor devices is present in the second region. A contact wire is located on a surface of a ...
Genetic detection platform
Pharmozyme, Inc.
September 14, 2017 - N°20170260580

Disclosed herein are methods, compositions, apparatus, systems and kits for performing polynucleotide amplification utilizing a pure polynucleotide polymerase. In some cases, disclosed herein are methods, compositions, apparatus, systems and kits for sequencing polynucleotides.
Sequencing reactions with lithium for pulse width control
Pacific Biosciences Of California, Inc.
September 14, 2017 - N°20170260579

Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having lithium that control the median pulse width for incorporated nucleotides are disclosed. The levels of lithium are used to control pulse width while allowing other sequencing parameters to remain within a desirable range.
Method for improving nucleic acid synthesis reaction
Takara Bio Inc.
September 14, 2017 - N°20170260578

Provided are the following: a method, for improving reactivity of an acid synthesis reaction, comprising a step for adding an ω-amino acid to a reaction solution; a composition, for a nucleic acid synthesis reaction, comprising dna polymerase, reaction buffer, at least one primer, at least one deoxyribonucleoside triphosphate, and an ω-amino acid; and a reaction buffer, ...
Polymerase compositions, methods of making and using same
Life Technologies Corporation
September 14, 2017 - N°20170260512

The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified ...
Inhibitors for steroid response elements and rna polymerase ii and related methods
Life Technologies Corporation
September 14, 2017 - N°20170260169

The present invention relates to polyamides capable of inhibiting are-, gre- and ere-mediated gene regulation in cells. The present invention also relates to polyamides capable of modulating the activity of rna polymerase ii and p53. The invention also relates to methods to treat diseases related to are-, gre- and ere-mediated gene regulation and to rna polymerase ii and p53 activity.
Devices and methods for molecular diagnostic testing
Click Diagnostics, Inc.
September 14, 2017 - N°20170259263

A hand-held molecular diagnostic test device includes a housing, an amplification (or pcr) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (pcr) on the input sample. The detection module is configured ...
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