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Polymerase

Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Tagged multi-nucleotides useful for nucleic acid sequencing
Roche Sequencing Solutions, Inc.
November 30, 2017 - N°20170342485

The present disclosure relates to tagged multi-nucleotide compounds, which comprise a single tag moiety covalently linked to a plurality of nucleoside-5′-oligophosphate moieties. As disclosed herein, these tagged multi-nucleotide compounds have improved characteristics as polymerase substrates and can be used in a range of nucleic acid detection and sequencing methods, including nanopore sequencing-by-synthesis.
Recombinase polymerase amplification
Alere San Diego, Inc.
November 30, 2017 - N°20170342473

This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed ...
Linear-expo-linear pcr (lel-pcr)
Bdrandeis University
November 23, 2017 - N°20170335383

Disclosed herein is a nucleic acid amplification process referred to as linear-expo-linear polymerase chain reaction (lel-pcr).
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Biocatalytic transamination process
Korea Advanced Institute Of Science And Technology
November 23, 2017 - N°20170335359

Employing dynamic kinetic resolution (dkr). The dkr process involves an enzymatic enantioselective amination reaction catalyzed by transaminases. The process can be used to manufacture key intermediates in the preparation of poly (adp-ribose) polymerase (parp) inhibitors which may be useful for the treatment of cancer.
Pyrimidine phosphonic acid esters
Concert Pharmaceuticals, Inc.
November 23, 2017 - N°20170334937

This invention relates to compounds of formula (a), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a viral dna polymerase inhibitor.
Methods for adding adapters to nucleic acids and compositions for practicing the same
Takara Bio Usa, Inc.
November 16, 2017 - N°20170327882

Provided are methods of adding adapters to nucleic acids. The methods include combining in a reaction mixture a template nucleic acid, a template switch oligonucleotide, a polymerase, and dntps. The reaction mixture components are combined under conditions sufficient to produce a product nucleic acid that includes the template nucleic acid and the template switch oligonucleotide each hybridized to adjacent regions ...
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Polymerase Patent Applications
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inventor
  • 270+ full patent PDF documents of Polymerase-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Analytical method for quanitification of viable bacteria contained in microbiota restoration therapy (mrt) compositions
Rebiotix, Inc.
November 16, 2017 - N°20170327862

Quantification of the viable bacterial microorganisms in a drug product for delivery via a gastro-nasal tube, an enema and/or a capsule or tablet. A molecular-based approach, such as pma (propidium monazide)-qpcr (quantitative polymerase chain reaction) assays may be useful for quantification of viable bacteria. By utilizing pma treatment in combination with qpcr, the number of viable bacterial cells ...
Thermostable reverse transcriptase
Board Of Regents, The University Of Texas System
November 16, 2017 - N°20170327818

Embodiments of the disclosure concern methods and compositions related to generation and/or use of proofreading reverse transcriptases, including those that are thermophilic or hyperthermophilic. The disclosure encompasses specific recombinant polymerases and their use. In some embodiments, the polymerases are utilized for rna sequencing in the absence of generation of a cdna intermediate.
Recombinant polymerases for improved single molecule sequencing
Pacific Biosciences Of California, Inc.
November 16, 2017 - N°20170327801

Provided are compositions comprising recombinant dna polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, ...
Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
Momentum Bioscience, Ltd.
November 09, 2017 - N°20170321287

An assay kit of reagents including a nucleic acid capable of acting as substrate for polymerase microorganism activity useful in a method of detecting polymerase activity as an indicator of the presence of a micro-organism in a sample are disclosed. The disclosed embodiments also relate to reagents for use in such methods, and to test kits comprising such reagents for ...
Method of determining the nucleotide sequence of oligonucleotides and dna molecules
Life Technologies Corporation
November 09, 2017 - N°20170321269

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of dna polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a dna fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base ...
Modified nucleotide reagents
Pacific Biosciences Of California, Inc.
November 09, 2017 - N°20170321268

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
Porous matrix comprising nucleic acid primer-carbon material composites and pcr using the same
Korea Institute Of Science And Technology
November 09, 2017 - N°20170321265

A porous matrix according to the present disclosure, wherein a nucleic acid primer-carbon material composite in which one or more nucleic acid primer of a forward primer and a reverse primer as a polymerase chain reaction (pcr) primer is bound to a carbon material is included in the pores of the matrix, provides improved amplification efficiency as compared to a ...
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inventor
  • 270+ full patent PDF documents of Polymerase-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods and reagents for reverse-transcription polymerase chain reaction
Ge Healthcare Uk Limited
November 09, 2017 - N°20170321250

The present invention provides a method of amplifying an rna molecule in a biological sample by reverse transcription pcr (rt-pcr), wherein the rt-pcr is carried out in a solution comprising a polar aprotic solvent; a serum albumin, and a polyol.
Polymerases
Illumina, Inc.
November 09, 2017 - N°20170321195

Presented herein are methods and compositions for thermostable dna polymerases that may be used to improve the pcr process and to improve the results obtained when using a thermostable dna polymerase in other recombinant techniques such as dna sequencing, nick-translation, and reverse transcription.
Methods for culturing and analyzing cells
Stokes Bio Limited
November 09, 2017 - N°20170320025

A system for analyzing a biological sample may include at least one sample acquisition stage comprising a sample acquisition device for acquiring the biological sample from a sample source; a droplet generator device for forming a droplet wrapped in an immiscible carrier fluid, wherein the wrapped droplet comprises at least the biological sample and a reagent, the droplet generator configured ...
Method of nucleic acid sequence determination
Stokes Bio Limited
November 02, 2017 - N°20170314072

Provided are sequencing-by-binding methods of detecting cognate nucleotides using a crippled dna polymerizing enzyme that possesses the ability to bind the next correct nucleotide downstream of a primer in a template-dependent fashion, but does not possess the activity needed to promote phosphodiester bond formation. Use of the crippled dna polymerase permits interrogation of one nucleotide at a time, without incorporation ...
Sequencing method employing ternary complex destabilization to identify cognate nucleotides
Stokes Bio Limited
November 02, 2017 - N°20170314064

Provided are methods and systems for detecting formation of nucleotide-specific ternary complexes comprising a dna polymerase, a nucleic acid, and a nucleotide complementary to the templated base of the primed template nucleic acid. The methods and systems facilitate determination of the next correct nucleotide without requiring chemical incorporation of the nucleotide into the primer. These results can even be achieved ...
Digital polymerase fidelity assay
Stokes Bio Limited
November 02, 2017 - N°20170314060

Methods of determining polymerase fidelity are provided. In one embodiment, the method comprises filling a gapped plasmid with a polymerase to form a gap-filled plasmid, wherein the gap-filled plasmid comprises a gene encoding an protein that is functional or non-functional depending on the polymerase fidelity; forming a plurality of partitions from a solution comprising the gap-filled plasmid and a label ...
Peptides useful for treating cancer
Stokes Bio Limited
November 02, 2017 - N°20170313746

Provided is a class of peptides which are useful for modulating the activity of poly (adp-ribose) polymerase (parp) and in particular for the treatment of cancer. The peptides include an active group and a cassette for delivering the active group to a cell. Also provided are peptides having an anionic group which is believed to act as a competitive inhibitor ...
Massive parallel method for decoding dna and rna
Stokes Bio Limited
November 02, 2017 - N°20170313737

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of dna in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable ...
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