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Polymerase

Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Isotachophoresis enhanced isothermal nucleic acid amplification
University Of Washington
April 12, 2018 - N°20180100183

The present disclosure relates generally to the integration of isotachophoresis (itp) and isothermal nucleic acid amplification methods such as recombinase polymerase amplification (rpa). One aspect of the disclosure relates to a method for concentrating and amplifying a nucleic acid, the method including an isotachophoresis device, the isotachophoresis device including a porous matrix, and first and second electrodes, having a leading ...
Test kits and methods for their use to detect genetic markers for transitional cell carcinoma ...
Pacific Edge Limited
April 05, 2018 - N°20180094323

This invention relates to methods for detecting the presence of genetic markers for transitional cell carcinoma of the bladder. Specifically, this invention relates to detection of expression of overexpressed and underexpressed genetic markers and calculation of ratios of expression of these markers. In additional aspects, the invention relates to polymerase chain reaction (pcr) based kits for carrying out these methods.
Nucleic acid amplification
Theranos, Inc.
April 05, 2018 - N°20180094306

Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such nucleic acid polymerases and primers.
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Polymerase variants
Roche Molecular Systems, Inc.
April 05, 2018 - N°20180094249

The present disclosure provides variant pol6 polymerase polypeptides, compositions comprising the pol6 variant polypeptides, and methods for using the variant pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental pol6 polypeptides ...
Tricyclic inhibitors of poly(adp-ribose)polymerase
Newgen Therapeutics, Inc.
April 05, 2018 - N°20180094010

The invention provides for compositions comprising phosphorous containing tricyclic compounds, including phthalazin-1(2h)-one derivatives. The compounds are potent inhibitors of the enzyme poly(adp-ribose)polymerase (parp), particularly parp-1 and potentially parp-2. The also show good cellular activity in inhibiting poly(adp-ribose) oligomer formation. The compounds may be useful as mono-therapy or in combination with other therapeutic agents in the ...
Salts and polymorphs of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6...
Pfizer Inc.
April 05, 2018 - N°20180092925

The present invention relates to novel polymorphic forms of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(adp-ribose) polymerase activity including the disease condition such as ...
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Polymerase Patent Applications
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  • 270+ full patent PDF documents of Polymerase-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction
Roche Molecular System, Inc.
March 29, 2018 - N°20180087090

The present disclosure relates to a method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction (dpcr) and to a method for determining the amount or concentration of a nucleic acid of interest in a sample with dpcr.
Single nucleotide detection method
Base4 Innovation Ltd
March 22, 2018 - N°20180080074

A method of sequencing a nucleic acid such as dna or rna is provided. It is characterised by the steps of (1) generating a stream of single nucleoside triphosphates by progressive pyrophosphorolysis of the nucleic acid; (2) producing at least one substantially double-stranded oligonucleotide used probe by reacting in the presence of a polymerase and a ligase at least one of the ...
Method and system for sequencing nucleic acids
Omniome, Inc.
March 22, 2018 - N°20180080073

Provided are compositions, methods and systems for determining the sequence of a template nucleic acid using a polymerase-based, sequencing-by-binding procedure. An examination step involves monitoring the interaction between a polymerase and template nucleic acid in the presence of one or more nucleotides. Identity of the next correct nucleotide in the sequence is determined without incorporation of any nucleotide into the ...
Led driven plasmonic heating apparatus for nucleic acids amplification
The Regents Of The University Of California
March 22, 2018 - N°20180080064

Systems and methods for plasmonic heating by combined use of thin plasmonic film-based 2d and 3d structures and a light-emitting diode (led) for nucleic acids amplification through fast thermal cycling of polymerase chain reaction (pcr) are described.
Whole expressed cell as antigen carrier, and use thereof in preparing vaccine or diagnostic agent, ...
Formosa Biomedical Inc.
March 22, 2018 - N°20180080042

A mammalian cell co-transfect with an expression plasmid comprising t7 promoter and an open reading frame (orf) of target antigen, and a vt7 recombinant vaccinia virus expressing t7 polymerase. The entire antigen expressing cell is used as a carrier of the target antigen for preparing a vaccine or diagnostic agent, and screening monoclonal antibodies.
Microfluidic siphoning array for nucleic acid quantification
Combinati Incorporated
March 22, 2018 - N°20180078935

In some aspects, the present disclose provides methods for amplifying and quantifying nucleic acids. Methods for amplifying and quantifying nucleic acids comprise isolating a sample comprising nucleic acid molecules into a plurality of microchambers, performing a polymerase chain reaction on the plurality of microchambers, and analyzing the results of the polymerase chain reaction. In some aspects, the present disclosure provides ...
Qualitative and absolute quantification kit for detecting hepatitis b virus cccdna
March 15, 2018 - N°20180073087

A composition for detecting hepatitis b virus cccdna includes an upstream primer having the dna sequence set forth in seq id no. 1, a downstream primer having the dna sequence set forth in seq id no. 2, and a taqman probe having the dna sequence set forth in seq id no. 3. A qualitative and absolute quantification kit for detecting hepatitis c virus ...
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Download 270+ patent application PDFs
Polymerase Patent Applications
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inventor
  • 270+ full patent PDF documents of Polymerase-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Dumbbell-structure oligonucleotide, nucleic acid amplification primer comprising same, and nucleic acid amplification method using same
Diogene Co., Ltd
March 15, 2018 - N°20180073082

The present invention relates to a dumbbell-structure oligonucleotide (dso), a nucleic acid amplification primer comprising the same, and a nucleic acid amplification method using the same and, more specifically, to a method for multi-gene amplification and single-nucleotide polymorphism analysis using a dumbbell-structure oligonucleotide capable of excluding non-specific amplification products prior to binding to a template in a first cycle in ...
Hairpin-mediated amplification method
Agilent Technologies, Inc.
March 15, 2018 - N°20180073068

In some embodiments, the amplification method may comprise producing a reaction mix comprising: a nucleic acid sample, a polymerase, nucleotides, a forward primer that hybridizes to a sequence in the bottom strand of a fragment in the sample, and a reverse primer. The reverse primer has a hairpin structure comprising a loop, a stem and a 3′ overhang of at ...
Methods for constructing consecutively connected copies of nucleic acid molecules
March 15, 2018 - N°20180073057

Methods for constructing consecutively connected and optionally truncated copies of nucleic acid molecules are disclosed. Consecutively connected copies of nucleic acid molecules can be used to perform sequencing of the same nucleic acid molecules several times, improving overall accuracy of sequencing. Sequencing of truncated copies of nucleic acid molecules can be used to deduce the sequences of nucleic acid molecules ...
Pcr method
Salisbury Nhs Foundation Trust
March 15, 2018 - N°20180073053

A method for generating amplicon constructs of a target sequence is disclosed, the method comprising providing a target sequence; an oligonucleotide probe, comprising a universal sequence and further comprising, at or towards its 5′ end, a target specific sequence capable of hybridising to the reverse complement of a sequence at, or flanking one of the 3′ ends of the target ...
Novel expression regulating rna-molecules and uses thereof
Universität Wien
March 15, 2018 - N°20180073026

The present application relates to a rna molecule comprising a rna-polymerase binding aptamer, wherein said rna-polymerase binding aptamer has a length of 15 to 60 nt, wherein said rna-polymerase binding aptamer binds to a rna-polymerase with a kd of 50 nm or lower. Furthermore, the application discloses a dna molecule comprising a sequence encoding an rna-polymerase binding aptamer of the invention, and a ...
Reaction mixtures
Roche Molecular Systems, Inc.
March 15, 2018 - N°20180073008

The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant dna techniques, especially nucleic acid amplification by the polymerase chain reaction (pcr).
Devices and methods for molecular diagnostic testing
Click Diagnostics, Inc.
March 15, 2018 - N°20180071734

A hand-held molecular diagnostic test device includes a housing, an amplification (or pcr) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (pcr) on the input sample. The detection module is configured ...
Pressurizable cartridge for polymerase chain reactions
Dxna Llc
March 15, 2018 - N°20180071733

A sample processing module includes a pcr assembly including at least one pcr reaction vial. A sample assembly is configured to hold a fluid sample therein, said sample assembly being attachable to said pcr assembly so as to form a closed system. A delivery channel is formed in said pcr assembly, said delivery channel being in fluidic communication with said ...
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