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Polymerase Chain Reaction patents



      
           
This page is updated frequently with new Polymerase Chain Reaction-related patent applications. Subscribe to the Polymerase Chain Reaction RSS feed to automatically get the update: related Polymerase RSS feeds. RSS updates for this page: Polymerase Chain Reaction RSS RSS


Detection and quantification of biomolecules using mass spectrometry

Dna fragment detection method, dna fragment detection kit and the use thereof

Date/App# patent app List of recent Polymerase Chain Reaction-related patents
08/21/14
20140236496
 Methods and systems for visualizing and evaluating data patent thumbnailnew patent Methods and systems for visualizing and evaluating data
A computer-implemented method of generating a digital polymerase chain reaction (dpcr) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period.
08/21/14
20140235464
 Detection and quantification of biomolecules using mass spectrometry patent thumbnailnew patent Detection and quantification of biomolecules using mass spectrometry
The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry.
08/21/14
20140234850
 Dna fragment detection method, dna fragment detection kit and the use thereof patent thumbnailnew patent Dna fragment detection method, dna fragment detection kit and the use thereof
The disclosure claims a cleaved deoxyribonucleic acid (dna) detection method, a dna fragment detection kit and use thereof. Wherein, the method includes the steps of: designing primers according to a test site or a test region of the dna fragment; cyclizing the dna fragment to obtain acyclized dna; implementing polymerase chain reaction (pcr) amplification for the cyclized dna by using the primers; and detecting the pcr amplification product.
08/14/14
20140228256
 Method and kit for constructing plasma dna sequencing library patent thumbnailMethod and kit for constructing plasma dna sequencing library
The disclosure relates a method and a kit for constructing a plasma deoxyribonucleic acid (dna) sequencing library. The method provided by the disclosure includes: extracting a plasma dna; making the plasma dna ligate to a sequencing linker, and purifying a ligation product; performing polymerase chain reaction (pcr) amplification for the purified ligation product, purifying the pcr amplification product, and obtaining the plasma dna sequencing library, wherein, the method does not include the step of performing 5′-terminus phosphorylation for the plasma dna.
08/14/14
20140228223
 High throughput paired-end sequencing of large-insert clone libraries patent thumbnailHigh throughput paired-end sequencing of large-insert clone libraries
The present invention is related to genomic nucleotide sequencing. In particular, the invention describes a paired end sequencing method that improves the yield of long-distance genomic read pairs by constructing long-insert clone libraries (i.e., for example, a fosill library or a foscn library) and converting the long-insert clone library using inverse polymerase chain reaction amplification or shearing and recircularization of shortened fragments into a library of co-ligated clone-insert ends.
07/31/14
20140213485
 Methods for preparing cdna from low quantities of cells patent thumbnailMethods for preparing cdna from low quantities of cells
Methods for preparing cdna libraries from single and low quantities of cells are disclosed. The methods are based on the principles of multi-strand displacement amplification or semi-random primed polymerase chain reaction.
07/31/14
20140212884
 Composition and methods for rt-pcr comprising an anionic polymer patent thumbnailComposition and methods for rt-pcr comprising an anionic polymer
The present invention is in the fields of molecular biology. The present invention is directed to novel compositions, methods and kits useful for the generation of nucleic acids from an rna template and further nucleic acid replication.
07/24/14
20140206855
 Methods and compositions for detecting cancers associated with methylation of hmlh1 promoter dna patent thumbnailMethods and compositions for detecting cancers associated with methylation of hmlh1 promoter dna
Methods are provided for detection of cancers associated with methylation of hmlh1 promoter dna in a subject. The method comprise assaying for the presence of methylated hmlh1 promoter dna in a bodily fluid from a subject.
07/17/14
20140200167
 Functionally integrated device for multiplex genetic identification patent thumbnailFunctionally integrated device for multiplex genetic identification
A biochip for multiplex genetic identification is disclosed. An biochip for separating and detecting a plurality of dna fragments includes a set of inputs and chambers for receiving a sample matrix of genetic material and reagents needed to conduct a polymerase chain reaction amplification of the genetic material.
07/17/14
20140199731
 Assay and other reactions involving droplets patent thumbnailAssay and other reactions involving droplets
The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments, the droplet or emulsion may be hardened to form a gel.
07/17/14
20140199730
Assays and other reactions involving droplets
The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments, the droplet or emulsion may be hardened to form a gel.
07/03/14
20140186828
Methods for determining cell viability using molecular nucleic acid-based techniques
The present invention relates to novel methods, and kits, for selectively excluding dead cells from a mixture containing live and dead cells, such as microbe cells in clinical samples, blood products, medical/biotechnology products and food products where subsequent interrogation of the selected live cells are an indicator of the presence of microbe viability. In particular, the invention relates to improved methods for performing direct nucleic acid amplification techniques such as polymerase chain reaction (pcr) and isothermal techniques in blood and other body fluids, for correlation with microbe cell viability from bacteremia and fungemia samples.
06/26/14
20140178880
Method of preparing a reaction mixture and related products
The invention relates to a method of preparing a reaction mixture for polymerase chain reaction (pcr) assay and a solution set for pcr. The method comprises providing a sample solution comprising a biological sample to be amplified in said pcr assay and first colorant providing the solution a first color, providing a reagent solution comprising at least one other substance required for performing said assay and second colorant providing the solution a second color different from the first color, and mixing the sample solution and the first reagent solution for providing a mixed solution to be subjected to the pcr process, the mixed solution having, due to said first and second colorants, a third color different from the first and second colors.
06/19/14
20140171334
Gene analysis method using sdl-pcr
According to the sdl-pcr method of the present invention, non-specific amplification can be minimized by removing non-ligated probes or genomic dna using a tag, and separation can be achieved within a shorter time compared to a separation method that is performed using exonuclease. In addition, ligation, separation and polymerase chain reaction processes can be performed in a single solution in a single tube, and thus a plurality of genes can be amplified at the same time in an accurate and rapid manner..
06/19/14
20140170706
Low-mass sample block with rapid response to temperature change
A sample block for use in the polymerase chain reaction, dna sequencing, and other procedures that involve the performance of simultaneous reactions in multiple samples with temperature control by heating or cooling elements contacting the bottom surface of the block is improved by the inclusion of hollows in the block that are positioned to decrease the mass of the block in the immediate vicinity of the wells.. .
06/12/14
20140162321
Preparation of gene-specific templates for the use in single primer amplification
This disclosure relates to methods for creating engineered templates that are useful for amplification of one or more antibody genes without the use of gene-specific primers. More specifically, templates engineered using these methods in a polymerase chain reaction setting which allows for the specific amplification of one or more antibody genes..
06/12/14
20140162267
Dry composition of reaction compounds with stabilized polymerase
The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (pcr) amplification after re-solubilization..
06/12/14
20140162266
Methods for polymerase chain reaction copy number variation assays
This disclosure provides methods for measuring the copy number for highly amplified and/or abundant genomic loci. Recognized herein is a need for methods for determining nucleic acid copy number, particularly in instances where one locus to be quantified (i.e., the target) is relatively more abundant than a locus of known abundance (i.e., the reference).
06/12/14
20140162261
Detection kit for identifying genotype in depression patients and method of using the same
The present invention relates to a rs6311 test kit, which includes a probe, a primer, and a polymerase chain reaction solution, wherein said probe sequence is as follows: rs6311t-fam: ctgtgagtgtctggc (seq. Id.
06/05/14
20140154681
Methods to predict breast cancer outcome
The present invention provides methods for predicting the outcome of a subject having breast cancer. The prediction model is based on the gene expression profile of the genes listed in table 1a or 1b.
05/29/14
20140147849
Quantitation of human genomic and mitochondrial dna
Methods are provided for determining, in a single polymerase chain reaction (pcr) reaction, the quantity, quality, and gender of origin of dna in a sample, and whether or not the sample contains pcr amplification inhibitors. The methods involve carrying out a single pcr multiplex reaction utilizing primer sets specific for amplifying: the human amelogenin locus; an x- and/or y-chromosome specific gene that is shorter than the amelogenin gene; at least one mitochondrial dna sequence, and preferably two differently-sized mitochondrial sequences; and a heterologous, non-human reporter gene..
05/22/14
20140141419
Single tube quantitative polymerase chain reaction (pcr)
Provided herein are systems and methods for quantitatively monitoring target amplicons produced by polymerase chain reaction (pcr). In particular, quantitative monitoring of target amplicon(s) in a single-tube pcr reaction without separate calibration reactions are provided..
05/15/14
20140134633
Detergent free polymerases
The present invention relates to a formulation of a thermostable dna polymerase which is completely free of detergents and its particular use in real time polymerase chain reaction (pcr). Such a formulation may be obtained if the selected purification method does not require the addition of a detergent at any purification step..
05/08/14
20140127702
Polymerization of nucleic acids using proteins having low isoelectric points
This disclosure relates to the use of one or more proteins (e.g., globular proteins) having a low isoelectric point and/or a limited number (e.g., zero) of modifying groups in nucleic acid polymerization and/or amplification reactions such as polymerase chain reaction (pcr).. .
04/24/14
20140113299
Inhibition-resistant polymerases
Provided herein are mutant polymerase enzymes resistant to inhibitors encountered in polymerase chain reactions (pcr). Also provided are nucleic acids or constructs encoding isolated polypeptides having polymerase activity.
04/10/14
20140099644
Novel compositions, methods and kits for real time polymerase chain reaction (pcr)
The present disclosure is directed to compositions, methods and kits for amplifying target nucleic acids while reducing non-specific amplification and undesired amplification products using a dual hot start reaction mixture that comprise at least two different hot start mechanisms.. .
04/10/14
20140099636
Field-based qpcr microbial monitoring
Dna/rna monitoring of microbes at an oil field to determine the presence and activity of harmful microbes is accomplished with a portable qpcr (quantitative polymerase chain reaction) machine. This permits the monitoring to occur on-site in the field and reduces the variability that may occur from the transportation of samples..
04/03/14
20140093942
Gene, ars-r anchorage cassette, ars-r expression-anchorage cassette, recombinant plasmid, bacterial transgenic lineage, use of said gene, use of said lineage in environmental bioremediation processes
The present invention relates to the construction and insertion of a dna plasmid vector of broad spectrum for gram-negative bacteria, that carries a gene sequence which, when expressed, enables the anchorage of a chelator protein for arsenic ions on the gram-negative bacteria cellular surface. For that end, the structural sequence of the regulatory arsr gene without stop codon (seq id no 1) was amplified by polymerase chain reaction (pcr) using as a template the chromosome 1 of cupriavidus metallidurans, ch34 lineage and inserted into the pgem-t cloning vector, yielding the pgemt-as plasmid (seq id no 2).
04/03/14
20140093872
Method of mutation detection in blood cell-free dna using primer extension (pe) and pcr
A method of detecting mutation in blood cell-free dna, includes providing a serum sample, isolating dna from the serum sample, amplifying the dna by polymerase chain reaction (pcr), subjecting the pcr product to primer extension (pe), and separating the pe reaction product and identifying the mutation by gel electrophoresis. In order to improve accuracy and sensitivity, the pe reaction can be carried out by using a primer that blocks the extension of the wild or non-mutated sequence..
03/20/14
20140080133
Thermally controlled chamber with optical access for high-performance pcr
Novel methods and systems for polymerase chain reaction (pcr) are disclosed. A pcr device has a bottom heater layer, a central reacting layer, and a top heater layer.
03/06/14
20140066322
Mouse cell line authentication
A multiplex polymerase chain reaction assay that targets nine tetranucleotide short tandem repeat (str) markers in the mouse genome. Unique profiles were obtained from seventy-two mouse samples that were used to determine the allele distribution for each str marker.
03/06/14
20140065702
Polymerase chain reaction
A polymerase chain reaction (pcr) device for a reverse transcriptase reaction (rt) and a convectively-driven polymerase chain reaction (cpcr) in the same device is provided. The pcr device comprises an upper temperature-controlling unit, a middle temperature-controlling unit and a lower temperature-controlling unit.
03/06/14
20140065609
Varietal counting of nucleic acids for obtaining genomic copy number information
A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (pcr) amplification, generating tag associated sequence reads by sequencing the product of the pcr reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion.. .
03/06/14
20140065603
Quantitative real-time assay for noroviruses and enteroviruses with built in quality control standard
A method is provided for reverse transcription-polymerase chain reaction (rt-pcr) comprising a) amplifying a reverse transcribed cdna in a mixture comprising norovirus genogroup i and norovirus genogroup ii primers and probes, wherein said norovirus primers and probes distinguish between genogroup i and genogroup ii viruses; b) quantifying virus; and c) normalizing data based on a universal internal rna control. Optionally, the method may also include primers and probes for enteroviruses.
03/06/14
20140065602
Human exhaled aerosol droplet biomarker system and method
A system and method for detecting a biomarker in exhaled breath condensate nanodroplets comprises noninvasively collecting exhaled breath condensate nanodroplets of a subject, and analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction to detect one or more target biomarkers.. .
02/27/14
20140057863
Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation
This invention also provides an effective process to quantify the viral load, and in particular bvdv, hcv or west nile virus load, in a host, using real-time polymerase chain reaction (“rt-pcr”). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample..
02/27/14
20140057279
Devices and methods for biological sample-to-answer and analysis
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk.
02/27/14
20140057210
Methods of fabrication of cartridges for biological analysis
Methods to fabricate reaction cartridges for biological sample preparation and analysis are disclosed. A cartridge may have a reaction chamber and openings to allow fluids to enter the chamber.
02/20/14
20140051159
Micro-fluidic modules on a chip for diagnostic applications
A chip having a substrate for amplifying genetic material includes a substrate heater having a plurality of substrate heating resistors. The heating resistors define a first temperature zone for maintaining a first temperature, a second temperature zone for maintaining a second temperature below the first temperature, and a third temperature zone for maintaining a third temperature between the first and second temperatures, on the substrate.
02/20/14
20140051155
Thermal cycler apparatus and related methods
An apparatus for thermal cycling can transfer heat uniformly and efficiently. The apparatus can be used in a method that reduces condensation on sample wells.
02/13/14
20140045250
Real-time optical system for polymerase chain reaction
An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.. .
02/13/14
20140045190
Method and device for monitoring real-time polymerase chain reaction (pcr) utilizing electro-active hydrolysis probe (e-tag probe)
A method for real-time electrochemical monitoring of pcr amplicons using a hydrolysis probe that is labeled with electro-active indicators and a microchip for implementing the method. The method provided is simpler and has higher specificity compared with the prior art.
02/06/14
20140038896
Retroelements and mental disorders and methods of measuring l1 retrotransposition
A method of treating increased non-ltr retrotransposition in a cell. The method includes exposing a neural cell to a retrotransposition inhibitor in an amount sufficient to decrease the non-ltr retrotransposition in the neural cell or a progeny of the neural cell.
01/30/14
20140031241
Paired end bead amplification and high throughput sequencing
The present invention is related to genomic nucleotide sequencing. In particular, the invention describes a paired end sequencing method that enables the sequencing of unique read pairs by co-localizing both 5′ ends on a single emulsion polymerase chain reaction bead.
01/02/14
20140005073
Method and apparatus for analyzing nucleic acid by compensating for crosstalk in polymerase chain reaction data and other data
A method of analyzing nucleic acid by compensating for crosstalk in polymerase chain reaction (pcr) data and other data, wherein crosstalk signals associated with multiple fluorescent dyes are corrected by using fluorescent intensity variations detected from a concentration difference of the fluorescent dyes, and apparatus for performing the method.. .
12/26/13
20130344539
Non-thermal cycling for polymerase chain reaction
Techniques, systems, and devices are disclosed for non-thermal cycling of polymerase chain reaction (pcr). In one aspect, a method for cycling pcr includes receiving an electrolytic fluid including ions, primers, polymerase enzymes, nucleotides, and a double-stranded nucleic acid in a fluid chamber having a first electrode and a second electrode, applying an electric field across the first and the second electrodes to generate a first ph level of the electrolytic fluid to denature the double-stranded nucleic acid to at least partial single strands, and applying a second electric field across the first and second electrodes to produce a second ph level of the electrolytic fluid, in which the second ph level enables binding of a polymerase enzyme and a primer with a corresponding segment of the single strands..
12/19/13
20130337444
Nano46 genes and methods to predict breast cancer outcome
The present invention provides methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype.
12/19/13
20130337434
Method of preparing magnetic bead type nasopharyngeal enzyme immunoassay reagents by polymerase chain reaction
A method of preparing magnetic bead type nasopharyngeal enzyme immunoassay reagents by polymerase chain reaction according to this invention offers in-vitro diagnostic reagents by means of utilizing nanotechnology. This method uses magnetic beads to coat ebv nuclear antigen (epstein-barr virus nuclear antigen, ebna1) or early antigen (early antigen, ea).
11/28/13
20130315886
Retroelements and mental disorders and methods of measuring l1 retrotransposition
A method of treating increased non-ltr retrotransposition in a cell. The method includes exposing a neural cell to a retrotransposition inhibitor in an amount sufficient to decrease the non-ltr retrotransposition in the neural cell or a progeny of the neural cell.
11/21/13
20130310269
Hot-start digital pcr
The present disclosure provides methods and compositions for performing nucleic acid reactions, such as hot-start digital polymerase chain reaction (dpcr).. .
11/21/13
20130309724
Step-up method for cold-pcr enrichment
Methods of using polymerase chain reactions to enrich a target sequence in a sample containing reference sequences and target sequences having high homology and amplifiable by the same primer pair are provided herein. In particular the methods provide a robust means to improve the fold enrichment of the target sequence and minimize reaction-to-reaction, well-to-well and run-to-run variations in the enrichment methods..
11/21/13
20130309684
Nucleic acid-free thermostable enzymes and methods of production thereof
The present invention provides thermostable enzymes, such as dna polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in amplifying or sequencing nucleic acid molecules, including through use of the polymerase chain reaction (pcr)..
11/14/13
20130303390
System for integrated analysis of real-time polymerase chain reaction and dna chip and method for integrated analysis using the same
Provided are a system for integrated analysis of a real-time polymerase chain reaction and a dna chip and a method for integrated analysis using the same, and more particularly to an apparatus for integrated analysis of a real-time polymerase chain reaction and a dna chip and a method for integrated analysis using the same. According to the method for integrated analysis of a biomaterial of the present invention, gene amplification proceeds and subsequently hybridization proceeds in a single reactor, thereby preventing contamination of the sample due to external factors, which may be caused while the sample is transferred for reaction, and automating a series of procedures such as injection of the sample, reaction of the biomaterial, and detection and analysis of results..
11/07/13
20130295663
Pressurizable cartridge for polymerase chain reactions
Methods and apparatus for use in connection with the performance of the polymerase chain reaction are provided. An exemplary sample processing module is described that includes a sample assembly and a pcr assembly, the sample processing module being configured to hold the sample therein at a pressure higher than ambient pressure.
10/31/13
20130288238
Methods and compositions for detecting serotypes of chlamydia trachomatis capable of causing lymphogranuloma venereum
Disclosed are methods and compositions for conducting assays utilizing real-time polymerase chain reactions (“pcrs”) in detection of serotypes l i, l ii, and l iii, but not stereotype b, of chlamydia trachomatis, capable of causing lymphogranuloma venereum (“lgv”). These assays take advantage of a deletion occurring in the cytotoxin gene locus specific to the l i, l ii, and l iii serotypes.
10/31/13
20130288229
Method for detection, differentiation and quantification of t cell populations by way of reverse transcription quantitative real time pcr (rt-qpcr) technology
The present invention relates to a method for detection, differentiation and quantification of t cell populations, comprising the following steps a) contacting a first aliquot of a body fluid of an individual with at least one antigen, wherein the body fluid contains antigen presenting cells (apc) and t cells, b) incubating the first aliquot with at least one antigen for a certain period of time, c) detection and differentiation of the t cell population by detecting in the first aliquot and in a second aliquot of the body fluid of the individual, which has not been incubated with the at least one antigen, at least a first marker of the apc induced by t cells in a specific t cell population using reverse transcription quantitative real time-time polymerase chain reaction (rt-qpcr), and d) detection and quantification of the t cell population by determining the ratio of the detected marker of the apc of the first aliquot to the second aliquot as well as a kit for performing the method.. .
10/24/13
20130282294
Methods and systems for processing data
The present invention is directed to methods and systems for applications relating to correction of numerical data resulting from dynamic changes to a true value. Such methods and systems may be used in accurate and unbiased quantitative polymerase chain reaction measurement..
10/17/13
20130274122
Assay for chlamydia trachomatis by amplification and detection of chlamydia trachomatis pmpa gene
A region of the chlamydia trachomatis pmpa gene has been identified which is useful for performing amplification assays to determine specifically whether c. Trachomatis is present in the sample being tested.
10/17/13
20130273535
Ndm-1 polymerase chain reaction (pcr) assay
Provided herein are compositions, methods, and kits for detection, identification, and analysis of ndm-1 variant nucleic acid. In particular, provided herein are kits, compositions, and methods for the detection, identification, and analysis of the ndm-1 variant nucleic acid and bacteria o other organisms carrying the ndm-1 variant nucleic acid..
10/10/13
20130266948
Apparatus and methods for integrated sample preparation, reaction and detection
Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided, as are methods for using such cartridges. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction.
10/03/13
20130259899
Detection of fusobacterium in a gastrointestinal sample to diagnose gastrointestinal cancer
Fusobacterium is a genus of gram-negative, filamentous, anaerobic bacteria found as normal flora in the mouth and large bowel, and often in necrotic tissue. A comparison of microbial ribonucleic acids (rna) between colorectal carcinoma (crc) tissue and adjacent normal control tissue found the over-representation of f.
09/26/13
20130252238
Polymerase chain reaction detection system
The present invention relates to methods and kits for nucleic acid detection in an assay system.. .
09/19/13
20130244286
Compositions and methods for cdna synthesis
Compositions are also provided comprising mixtures of reagents, including reverse transcriptases, buffers, cofactors and other components, suitable for immediate use in conversion of rna into cdna and rt pcr without dilution or addition of further components. These compositions are useful, alone or in the form of kits, for cdna synthesis or nucleic acid amplification (e.g., by the polymerase chain reaction) or for any procedure utilizing reverse transcriptases in a variety of research, medical, diagnostic, forensic and agricultural applications..
09/12/13
20130237428
Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions
Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid..
09/05/13
20130230848
Oligonucleotides useful in methods for detecting and characterizing aspergillus fumigatus
Methods for using oligonucleotides in the detection of aspergillus fumigatus are disclosed. The oligonucleotides of the invention have nucleotide sequences derived from the gene encoding the cytochrome p450 14 alpha-sterol demethylase (the cyp51a protein) of aspergillus fumigatus.
09/05/13
20130230529
Novel paramyxovirus and uses thereof
Described herein are isolated paramyxovirus, a morbillivirus (fmopv), isolated nucleic acids encoding the genome of fmopv, isolated amino acid sequences of fmopv proteins, antibodies to fmopv and its proteins, and uses thereof. In certain embodiments, the modified fmopv is a feline morbillivirus.
08/29/13
20130225426
Reactivity-dependent and interaction-dependent pcr
Methods, reagents, compositions, and kits for reactivity-dependent polymerase chain reaction (rd-pcr) and interaction-dependent polymerase chain reaction (id-pcr) are provided herein. Rd-pcr is a technique useful for determining whether a reactive moiety can form a covalent bond to a target reactive moiety, for example, in screening a library of candidate reactive moieties for reactivity with a target reactive moiety, and in identifying an enzyme substrate, for example, in protease substrate profiling.
08/29/13
20130224746
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (pcr) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence.
08/22/13
20130217112
Reaction tube for performing isothermal polymerase chain reaction therein
A reaction tube for performing isothermal polymerase chain reaction therein is provided and includes an upper section, a lower capillary section, a linkage connecting the upper section and the lower capillary section, and a thermal conductor. The lower capillary section has an annealing portion, an annular heating groove, and a close end.
08/22/13
20130217071
Methods and compositions for performing nucleic acid amplification reactions
The present disclosure provides methods and compositions for performing nucleic acid reactions, such as the reverse transcriptase-polymerase chain reaction (rt-pcr).. .
08/22/13
20130217025
Chimeric dna identifier
Devices and methods for delivering a chimeric deoxyribonucleic acid (dna) marking agent to a target and identifying the target from the chimeric dna marking agent are provided. A delivery device may be a projectile, a spray canister or a wet/dry article.


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Polymerase Chain Reaction topics: Polymerase Chain Reaction, Polymerase, Nucleic Acid, Nucleotide, Quantitative, Amplification, Chlamydia Trachomatis, Nucleic Acids, Transcription, Oligonucleotide, Sequencing, Real Time Pcr, Differentiation, Lymphogranuloma Venereum, Recombinant

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