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This page is updated frequently with new Platelet-related patent applications. Subscribe to the Platelet RSS feed to automatically get the update: related Platelet RSS feeds. RSS updates for this page: Platelet RSS RSS


Methods and systems for fabricating platelets of a monochromator for x-ray photoelectron spectroscopy

Methods and systems for fabricating platelets of a monochromator for x-ray photoelectron spectroscopy

Date/App# patent app List of recent Platelet-related patents
02/26/15
20150056643
 Microfluidic devices for measuring platelet coagulation and associated systems and methods patent thumbnailnew patent Microfluidic devices for measuring platelet coagulation and associated systems and methods
The present technology relates generally to microfluidic devices for measuring platelet coagulation, and associated systems and methods. In some embodiments, a fluidics device includes an array of microstructures including pairs of generally rigid blocks and generally flexible posts.
University Of Washington Through Its Center For Commercialization
02/26/15
20150056604
 Compositions and  methods for preserving platelet function patent thumbnailnew patent Compositions and methods for preserving platelet function
Compositions and methods for maintaining platelet functionality and extending the shelf-life of platelets are described. Platelet preservation compositions include a photosensitizer and a plurality of platelet preservation agents.
Biovec Transfusion, Llc
02/26/15
20150056602
 Apheresis platelets with fixed residual plasma volume patent thumbnailnew patent Apheresis platelets with fixed residual plasma volume
Methods and systems for obtaining platelets are disclosed. Platelets are collected in a pre-determined volume of plasma and a determined amount of a combined storage medium including the pre-determined amount of plasma and a volume of a synthetic additive solution..
Fenwal, Inc.
02/26/15
20150052723
 Methods and systems for fabricating platelets of a monochromator for x-ray photoelectron spectroscopy patent thumbnailnew patent Methods and systems for fabricating platelets of a monochromator for x-ray photoelectron spectroscopy
Methods and systems for fabricating platelets of a monochromator for x-ray photoelectron spectroscopy (xps) are disclosed. For example, a method of fabricating a platelet of a monochromator for x-ray photoelectron spectroscopy involves placing a crystal on a stage of an x-ray measuring apparatus, the crystal having a top surface.
02/19/15
20150050677
 Methods and systems for measuring whole blood platelet reactivity patent thumbnailMethods and systems for measuring whole blood platelet reactivity
The invention relates to a novel approach and related methods and systems, which provide accurate and easily implemented measurement and analyses of whole blood platelet reactivity, and impact on treatment thereof.. .
University Of Massachusetts Medical School
02/19/15
20150050641
 Method for the enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates patent thumbnailMethod for the enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates
A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic acid staining dye that stains dna (micronuclei) in erythrocyte populations. Because the fluorescent emission spectra of the first and second fluorescent labeled antibodies do not substantially overlap with one another or with the emission spectra of the nucleic acid staining dye, upon excitation of the labels and dye it is possible to detect the fluorescent emission and light scatter produced by the erythrocyte populations and platelets, and count the number of cells from one or more erythrocyte populations in said sample.
Litron Laboratories, Ltd.
02/19/15
20150050331
 Method for making a topical composition comprising growth factors derived from human umbilical cord blood platelets patent thumbnailMethod for making a topical composition comprising growth factors derived from human umbilical cord blood platelets
The present invention is directed to a method of making a stable composition comprising growth factors, which may include platelet derived growth factors and transforming growth factors. The method comprises providing human umbilical cord blood plasma containing platelets, but substantially free of whole blood cells, and lysing the platelets to extrude growth factors into the plasma.
Novo Solutions Md, Llc
02/19/15
20150050325
 Organic compounds patent thumbnailOrganic compounds
The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to a drug-eluting stent comprising said compounds and methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery..
The Rockefeller University
02/12/15
20150044574
 Polymer electrolyte membranes for rechargeable batteries patent thumbnailPolymer electrolyte membranes for rechargeable batteries
An electrolyte membrane for use in a rechargeable battery includes a polymer layer and platelet particles, where the polymer layer is reinforced with a fiber mat, and the polymer layer retains an electrolyte. A rechargeable battery uses the membrane in a position between a positive electrode and negative electrode where the membrane serves as an ion conductor for the battery..
02/12/15
20150044469
 Mineral composition made from a mixed solid phase of calcium and magnesium carbonates,  preparing same and use thereof patent thumbnailMineral composition made from a mixed solid phase of calcium and magnesium carbonates, preparing same and use thereof
A mineral composition made from a mixed solid phase of calcium and magnesium carbonates, method of preparing same and use thereof. A mineral composition made from a mixed solid phase of calcium and magnesium carbonates, formed from a crystallised calcium portion and a crystallised magnesium portion in the form of platelets, the crystals of the calcium portion and those of the magnesium portion being aggregated in the form of composite aggregates, said aggregates themselves being at least partially agglomerated, said calcium portion comprising at least one carbonate chosen from the group consisting of calcite, aragonite and the mixtures thereof, said magnesium portion comprising hydromagnesite in platelet form, said mixed solid phase having a bulk density less than or equal to 250 kg/m3, and greater than or equal to 80 kg/m3, measured according to standard en 459.2..
S.a. Lhoist Recherche Et Developpement
02/05/15
20150038492

Benzamides and nicotinamides as syk modulators


The present invention is directed to compounds of formula i and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as non hodgkin's lymphoma..
Portola Pharmaceuticals, Inc.
02/05/15
20150038449

Maintenance of platelet inhibition during antiplatelet therapy


A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients in need of antiplatelet therapy or at risk of thrombosis.
The Medicines Company
02/05/15
20150037821

Methods of identifying hit-antibodies and pf4 antagonists and cell lines for use therein


Methods and cells or cell lines for identifying antibodies or fragments thereof that activate heparin-induced thrombocytopenia (hit) are described. The methods comprise contacting a hematopoietic cell or cell line that comprises, in operative association, the platelet receptor fcyriia under the control of a suitable promoter, and a reporter construct comprising a reporter gene under the control of a promoter and transcription factor, which transcription factor is regulated downstream of the signaling cascade of activated fcyriia, with a test sample from a mammalian subject; a platelet factor 4 (pf4), a wild-type or variant of pf4 or a fragment thereof; and heparin; and detecting or measuring the level of reporter gene expression..
The University Of Birmingham
02/05/15
20150037431

Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities


Methods and kits for treating a cardiac arrhythmia using a platelet rich plasma (prp) composition are provided. Any type of arrhythmia may be treated using the prp composition.
Bioparadox, Llc
02/05/15
20150037430

Formulation of a blood composition that is rich in platelet and/or growth factors and contains gelled proteins, and a its preparation


Formulation comprising, or derived from, an initial blood composition, wherein the formulation is rich in platelets and/or growth factors and proteins originating from the initial blood composition, and wherein the proteins are in a gelled state. The invention also refers to method for preparing the formulation, comprising the steps of heating and then cooling the initial blood composition at certain temperatures and times.
Biotechnology Institute, I Mas D, S.l.
02/05/15
20150037239

Dispersion and retrieval of de-bundled nanotubes


A method for dispersing nanotubes, comprising forming a nanocomposite solution with associated nanotubes and nanoplatelets, mixing a surfactant to the nanocomposite solution, separating the nanocomposite in solution, wherein the nanotubes remain suspended in the surfactant solution, and isolating the nanotubes in solution. In certain instances, the method further comprises functionalizing the nanotubes in solution..
The Texas A&m University System
02/05/15
20150034990

Controlling led emission pattern using optically active materials


A light emission device comprising a light emitting element, a wavelength conversion (e.g. Phosphor) element, and a filter that reduces color over angle (coa) effects by at least partially reflecting light from the light emitting element that strike the filter at near-normal angles of incidence.
Koninklijke Phillips N.v.
01/29/15
20150031567

Mirna biomarkers for ulcerative colitis


Methods for diagnosing inflammatory bowel disease and ulcerative colitis using mirna biomarkers for these diseases are provided. Differential expression of the mirna biomarkers in blood fractions, e.g., platelets, of diseased individuals as compared to expression levels in normal individuals indicates the presence of ibd or ulcerative colitis.
Genisphere, Llc
01/29/15
20150030578

Method for producing activated autologous platelet rich and platelet poor plasma and methods of use


A method and kit to produce activated autologous platelet rich and platelet poor plasma (aaprpp) and methods of use to treat pain. The method to produce aaprpp generally comprising (1) obtaining whole blood from patient; (2) centrifuging whole blood in a collection tube; (3) extracting platelet rich and platelet poor plasma mixture from collection tube; and (4) transferring platelet rich and platelet poor plasma mixture to an activation tube containing at least one platelet aggregator and at least one platelet activator to obtain a resulting platelet concentration.
01/29/15
20150030500

Irradiation inactivating pathogens and/or leukocytes in a biological fluid and process


The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising: a casing (2), a support member (3) for carrying at least one irradiation bag (19) containing the biological fluid, a light source (4) comprising two banks of light (5, 6) disposed above and below the support member (3), and an agitating system (25) for moving the support member (3), the light source generating uvc light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to uvc.. .
Maco Pharma S.a.
01/29/15
20150027900

Production of graphene


A method for the production of graphene and graphite nanoplatelet structures having a thickness of less than 100 nm in an electrochemical cell, wherein the cell comprises: (a) a negative electrode which is graphitic; (b) a positive electrode which may be graphitic or another material; and (c) an electrolyte which is ions in a solvent where the cations are organic ions and metal ions; and wherein the method comprises the step of passing a current through the cell.. .
The University Of Manchester
01/22/15
20150025223

System and producing interleukin receptor antagonist (ira)


The present invention relates to a system and method for producing high levels of autologous il-1ra cytokine, comprising: a blood collection vessel (1), a cover (4), a portion of separation gel (2), an anticoagulant portion (3), a plasma collection syringe comprising a sharp needle (9), a buffy coat collection syringe (11) and an incubation tube with cover (15). The vessel is adapted such that, when containing the whole blood (5), and centrifuged after treatment, yields separation fractions comprising, a first fraction of rbcs sediment (6), a second fraction of said gel (2), a third fraction comprising wbcs, platelets and), and fourth fraction of plasma solution (8)..
Estar Technologies Ltd
01/22/15
20150025030

Hydroxysafflor yellow a sodium and preparation as well as application thereof


A hydroxysafflor yellow a sodium compound as shown in a formula (i) and preparation as well as medicinal application thereof are provided. According to the present invention, the safflower is utilized as a raw material.
Zhejiang Yongning Pharmaceutical Co Ltd
01/22/15
20150024431

Thrombopoietic compounds


The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal..
Amgen Inc.
01/22/15
20150024042

Phased dosing of clopidogrel


The present invention provides for novel formulations of clopidogrel to provide for phased/spaced release for use as improved antiplatelet therapies in stroke and cardiovascular indications.. .
Pozen Inc.
01/22/15
20150023976

Antibody polypeptides that antagonize cd40l


Antibody polypeptides that specifically bind human cd40l are provided. The antibody polypeptides do not activate platelets.
Domantis Limited
01/22/15
20150023975

Par-1 activation by metalloproteinase-1 (mmp-1)


Matrix metalloproteases (mmps) play many important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis and cancer. This invention relates to the activation of protease-activated receptor-1 (par-1) by endogenous platelet mmp-1 collagenase on the surface of platelets.
Tufts Medical Center, Inc.
01/22/15
20150021196

Electrochemical producing nano graphene platelets


A method of producing nano-scaled graphene platelets with an average thickness smaller than 30 nm from a layered graphite material. The method comprises (a) forming a carboxylic acid-intercalated graphite compound by an electrochemical reaction; (b) exposing the intercalated graphite compound to a thermal shock to produce exfoliated graphite; and (c) subjecting the exfoliated graphite to a mechanical shearing treatment to produce the nano-scaled graphene platelets.
01/15/15
20150018754

Devices, compositions and methods for treating acute and chronic tissue damage


A device to prepare and deliver a bioactive substance such as stem cells, platelet rich plasma, and/or other bioactive compositions. The device can utilize a hallow interior or cavity to deliver bioactive substances during a surgical procedure or to an area of cartilage defect or cartilage disorder.
01/15/15
20150018522

Catalytic domains of beta(1,4)-galactosyltransferase i having altered metal ion specificity


Disclosed are mutants of galactosyltransferases that can catalyze formation of oligosaccharides in the presence of magnesium; mutants of galactosyltransferases having altered donor and acceptor specificity which can catalyze formation of oligosaccharides in the presence of magnesium; methods and compositions that can be used to synthesize oligosaccharides; methods for increasing the immunogenicity of an antigen; and methods to stabilize platelets.. .
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servic
01/15/15
20150017404

Injection-moulded decorative moulded article with effect pigments and manufacturing method


A decorative moulding and a method for the production thereof. The decorative moulded article has at least one injection-moulded main body made of thermoplastic material; with a deep 3d surface structure on a visible surface and a cover layer of transparent plastic applied at least to the visible surface.
Daimler Ag
01/08/15
20150011982

Devices and methods for effecting faster healing of orthopedic and other wounds


Disclosed are medical devices, e.g., surgical sutures, surgical staples, surgical pads, surgical meshes, surgical scaffolds etc., and methods of use at a wound in a patient to facilitate the rapid healing of the tissue at the situs of the wound with minimal fibrous tissue formation. The devices are arranged to be brought into engagement with tissue adjacent the wound to close the wound and include a core formed of a piezo-electric material and an outer layer covering the core.
01/08/15
20150011583

Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof


Optically active 2-hydroxytetrahydrothienopyridine derivatives represented by formula i and pharmaceutically acceptable salts, preparation method and use in the manufacture of a medicament thereof are disclosed. The pharmacodynamic experiment results show that the present compounds of formula i are useful for inhibiting platelet aggregation.
Jiangsu Vcare Pharmatech Co., Ltd.
01/08/15
20150011507

Compositions comprising lecithin oils and nsaids for protecting the gastrointestinal tract and providing enhanced therapeutic activity


A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (nsaids) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a nsaid-containing formulation that possess low gastrointestinal (gi) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulsion for internal, oral, direct or topical administration..
The Board Of Regents Of The University Of Texas System
01/08/15
20150011371

Blood component separation device


Provided is a blood component separation device that can shorten the overall time to collect high-concentration platelet liquid for blood component donation, thereby reducing time to keep a donor for blood drawing. The blood component separation device includes a temporary storage bag (also used as a buffy coat bag) which is also used as a whole blood bag for storing whole blood drawn from the donor.
Terumo Kabushiki Kaisha
01/08/15
20150010995

Microchip-based examining platelet composite functions


There is provided a microchip-based platelet multi-function test apparatus. The apparatus includes a sample container configured to accommodate a blood sample therein, a stirrer that is installed inside the sample container and induces a shear flow in the blood sample, a parallel channel configured to divide and flow the blood stirred by the stirrer into a plurality of paths, a vacuum device that is connected to an end of each parallel channel, maintains constant pressure, allows the stirred blood to flow along the parallel channel, a light source that is installed in a rear side of the parallel channel and radiates light to the parallel channel, and an image sensor that receives light transmitted through the blood in the parallel channel, converts the light into an electrical signal, and measures a flowing distance of a blood flow..
Korea University Research And Business Foundation
01/08/15
20150010589

Aegyptin and uses thereof


The present invention relates to the discovery of the aegyptin gene and aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed..
The Regents Of The University Of California
01/08/15
20150007840

Replacement hair strand having a hair-joining element


The invention relates to a replacement hair strand having a hair-joining element, consisting of a flat thermoplastic platelet having a replacement hair strand embedded in the end thereof, wherein in order to ensure a secure join with a head hair strand at least one rib running obliquely with respect to the strand direction protrudes from one of the two flat sides of the platelet. At the base thereof, the rib can have approximately the thickness of the platelet, and towards the free end thereof, the rib can be tapered.
Hairdreams Haarhandels Gmbh
01/01/15
20150005374

Compounds and methods for delivery of prostacyclin analogs


This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.. .
United Therapeutics Corporation
01/01/15
20150005149

Centrifuge


Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. platelet rich plasma (prp) and or platelet poor plasma (ppp) can be obtained rapidly and is ready for immediate injection into the host.
Kensey Nash Corporation
01/01/15
20150004694

Medium and methods for the storage of platelets


Synthetic storage media are disclosed for use in the processing and the storing of platelets. The storage media includes a platelet storage solution and less than 20 percent plasma to preserve platelet function after at least 7 days of storage..
Fenwal, Inc.
01/01/15
20150004224

Dpa-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form


Dpa-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented. Also provided are methods of treating hypertriglyceridemia (200 mg/dl-500 mg/dl) by adjunctive administration of a statin and the pharmaceutical compositions described herein.
Chrysalis Pharma Ag
12/25/14
20140378456

Benzimidazole derivatives as pi3 kinase inhibitors


This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries.
Glaxosmithkline Llc
12/25/14
20140378290

Blood component separation device


A blood component separation device includes a centrifuge bowl for separating a blood component from blood, a plasma bag for storing a plasma component, a platelet intermediate bag for storing high-concentration platelet liquid having high-concentration of platelets, and a temporary storage bag (also used as a buffy coat bag) for storing low-concentration platelet liquid having low-concentration of platelets. The blood component separation device performs control, from the second cycle onward, to mix the low-concentration platelet liquid stored in the temporary storage bag in the immediately preceding cycle with whole blood to supply the mixed liquid to the centrifuge bowl.
Terumo Kabushiki Kaisha
12/25/14
20140377227

Tissue transplantation involving, and tissues modified by decellularization and recellularization of donor tissues for minimized or obviated rejection reactions


The method of tissue transplantation involving recellularizing of a donor organ with the utilization of the recipient's cytokines collected from the recipient's blood plasma at less than systemic pressure, and at the temperature greater than freezing and less than normal systemic temperature of the recipient's blood. Specifically, a method of harvesting a platelet-derived growth factors from platelet rich plasma (prp), the growth factors having increased weight..
12/25/14
20140377226

Tissue transplantation involving, and tissues modified by decellularization and recellularization of donor tissues for minimized or obviated rejection reactions


The method of tissue transplantation involving recellularizing of a donor organ with the utilization of the recipient's cytokines collected from the recipient's blood plasma at less than systemic pressure, and at the temperature greater than freezing and less than normal systemic temperature of the recipient's blood. Specifically, a method of harvesting a platelet-derived growth factors from platelet rich plasma (prp), the growth factors having increased weight..
12/25/14
20140377220

Gene expression signatures for staging and prognosis of prostate, breast and leukemia cancers


The present invention is drawn to methods of assessing and treating cancers such as erg-related, prostate, breast and leukemia, by examining the expression of combinations of particular genes disregulated in this disease state. The combinations of genes are selected from the following genes: inhibitor of growth family, member 3 (hstg3); lymphoid enhancer-binding protein factor 1 (lef1); frizzled-related protein (frzb); annexin a4 (anxa4); meis homeobox 2 (meis2); syndecan binding protein (syntenin) (sdcbp); ankyrin 3, node of ranvier (ankyrin g) (ank3); chromodomain helicase dna binding protein 5 (chd5); phospholipase a2, group vii (platelet-activating factor acetylhydrolase, plasma) (pla2g7); and wingless-type mmtv integration site family member 2 (wnt2)..
Uti Limited Partnership
12/25/14
20140377213

Wet-electrospun biodegradable scaffold and uses therefor


A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which comprises a mammalian blood product such as serum, plasma or platelet rich plasma. The matrix is useful as a cell-growth matrix and for repair of a tissue in a mammal, for instance by implantation in a mammal at a site in need of repair, such as in an abdominal wall..
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
12/18/14
20140371048

Integrated kit for separating blood and concentrating prp and extracting prp using the same


An integrated kit for separating blood and concentrating platelet rich plasma includes (a) a main body includes an upper storage portion, a lower storage portion, and a passage portion for connecting the upper storage portion and the lower storage portion; (b) a upper cover coupled to an upper end of the upper storage portion; (c) an inner stopper inserted into a lower end of the lower storage portion so as to seal the lower storage portion; (d) a closing adjustment screw which can move vertically while penetrating a hole formed at the inner stopper and seals the passage portion; and (d) a lower cover coupled to an outside of the lower end of the lower storage portion and the outside of the inner stopper to prevent the separation of the closing adjustment screw coupled to the inner stopper in case of centrifugation.. .
Rmedica Co., Ltd.
12/11/14
20140363423

Peptide compounds for inhibition of platelet aggregation


The invention relates to a peptide compound and its pharmaceutical composition for inhibiting platelet aggregation and preventing/treating thrombogenic diseases. The invention develops pentapeptides and hexapeptides derived from snake venom c-type lectin-like proteins (clps) fragments, which can inhibit platelet aggregation and have antithrombotic activity without hemorrhagic tendency.
12/11/14
20140363412

Platelet activation using long electric field pulses


Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses.
12/11/14
20140360944

System and obtaining a cellular sample enriched with defined cells such as platelet rich plasma (prp)


The invention relates to a system and method for obtaining a cellular fraction enriched with defined cells effective in promoting a defined cellular response from an in vivo cellular sample comprising: a collection tube for collecting a cell suspension (1), an anticoagulant portion (4), a portion of separation gel (3), a first collection syringe for collecting a cell depleted fluid (10), a second collection syringe for collecting the enriched cellular portion (11) and at least one needle (1o) for attaching to each syringe. The system is closable to the atmosphere, further wherein the cell suspension collection tube contains the gel (3) and the anticoagulant (4), the tube is adapted such that, when containing cell suspension and centrifuged after treatment yields separation fractions, a first fraction comprising cellular fluid (6), a second fraction comprises gel layer (3), a third fraction comprises enriched cellular portion (7) on top of the gel layer and a fourth fraction comprises a cell poor portion (8)..
12/04/14
20140357731

Healing cream


A method for formulating a cationic and non-ionic oil in water emulsion, preferably in a cream form, containing growth factors, preferably platelet derived growth factors, specific matrikine peptides, botanicals, emollients, nano-molecules, antioxidants, antiseptics, neuro-peptides, anti-dermatophytics, polysaccharides, sensorial peptides, osmotically driven moisturizers, and siloxane barriers. For application to the feet and other affected parts of the body for the relief of diabetic skin and tissue trauma..
12/04/14
20140357465

Systems and methods for extracting platelet-rich plasma for therapeutic injection


Systems and methods are provided for processing blood or a fluid containing blood plasma and platelets. The blood or fluid is continuously added into a fluid separation chamber, which is used to isolate platelet-rich plasma therein.
12/04/14
20140356893

Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation


Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions, and the use of compositions containing platelet-rich plasma to accelerate or complete the differentiation of a cell line. Particularly, use of platelet-rich plasma in conjunction with cell differentiation..
12/04/14
20140356851

System and the re-anticoagulation of platelet rich plasma


A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a prp container. The method may then transfer the anticoagulant within the prp container to a red blood cell container, and collect a volume of platelet rich plasma within the prp container.
12/04/14
20140356387

Method for inducing immune tolerance through targetted gene expression


A method of inducing immune tolerance against a protein of interest comprising the steps of (a) transducing hematopoietic stem cells with a gene for the protein of interest wherein the gene is operably connected to a platelet specific promoter, and (b) transplanting the transfected cells of step (a) into to a subject, wherein the protein is expressed, and wherein the subject develops immune tolerance against the protein.. .
11/27/14
20140350037

Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity


The present invention relates to a regimen for the administration of a pyrimidylaminobenzamide of formula i as defined herein for the treatment of proliferative disorders, particularly solid and liquid tumors, and other pathological conditions mediated by the bcr-abl oncoprotein, the cell transmembrane tyrosine kinase receptor c-kit, ddr1 (discoidin domain receptor 1), ddr2 (discoidin domain receptor 2) or pdgf-r (platelet derived growth factor receptor) kinase activity.. .


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Platelet topics: Growth Factor, Fibroblast, Nanoparticle, Autologous, Leukocytes, Circulation, Transforming Growth Factor, Therapeutical, Platelet Derived Growth Factor, Bone Morphogenetic Protein, Endothelial, Recombinant, Stem Cells, Respiratory System, Dispensing System

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