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This page is updated frequently with new Photodynamic Therapy-related patent applications.




 Radioluminescent compound for radiotherapy and deep photodynamic therapy and device for deep photodynamic therapy patent thumbnailRadioluminescent compound for radiotherapy and deep photodynamic therapy and device for deep photodynamic therapy
A radioluminescent compound for radiotherapy and deep photodynamic therapy (deep pdt), the radioluminescent compound including a molecular conjugate made up of a radioluminescent molecule and one photosensitizer, the radioluminescent molecule being suitable for absorbing an x-ray with energy higher than an absorption threshold and for emitting luminescent radiation in the visible domain, and the photosensitizer being suitable for absorbing the luminescent radiation and producing singlet oxygen. The radioluminescent compound is made up of a molecule of lanthanide chloride (lncl3); the photosensitizer is selected among the following photosensitizers: al(iii)phthalocyanine, mthpc, chlorin e6 (ce6), hypericin, hypocrellin, nile blue, oxazine 170, oxazine 1, protoporphyrin ix, 7-methoxycoumarin-4-acetic acid, bacteriochlorophyll, and auramin; and the photosensitizer is selected such as to maximize the energy transfer between an x-ray absorbed by the radioluminescent lanthanide 2 and the photosensitizer in order to produce singlet oxygen..
Synchrotron Soleil


 Space, luminous ceiling  conducting photodynamic therapy patent thumbnailSpace, luminous ceiling conducting photodynamic therapy
A space for conducting photodynamic therapy (pdt) for treatment of skin diseases, especially for treatment of superficial skin tumors such as actinic keratoses, basal cell carcinomas, and initial carcinomas, wherein an active ingredient is applied to a skin area to be treated in order to form porphyrins and irradiation with light is conducted to form singlet oxygen based on the porphyrins in order to destroy diseased skin cells, wherein the space has side walls, a ceiling, and a floor, as well as at least two lighting fixtures, which are separated from one another by at least 50 cm and illuminate at least a subregion of the space, wherein there is an illuminance of at least 8,000 lux at every point in the subregion and the subregion has horizontal dimensions of at least 1 m2 and a vertical height of at least 40 cm. This invention also relates to a luminous ceiling system and method for conducting pdt..
Swiss Red Ag


 Upconverting nanoparticles patent thumbnailUpconverting nanoparticles
Provided herein are lanthanide-containing upconverting nanoparticles, methods of their preparation, compositions, and methods of using the same. The polymers and compositions provided herein may be used, for example, in photodynamic therapy..

 Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy patent thumbnailProstate-specific membrane antigen-targeted photosensitizers for photodynamic therapy
Urea-based photosensitizers, which target prostate-specific membrane antigen (psma) for imaging and targeted therapy of psma-expressing tumors and cancers are disclosed.. .
The Johns Hopkins University


 Methods for use of small molecule activators of hem-y / protoporphyrinogen oxidase (ppo) patent thumbnailMethods for use of small molecule activators of hem-y / protoporphyrinogen oxidase (ppo)
Wherein r1 is h, alkyl, aryl, heteroaryl, r2 is h, halogen, alkyl, aryl, heteroaryl, r3 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r4 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r5 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r6 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r7 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r8 is —cr3, o, s, wherein r5 and r6, r7 and r6, r5 and r4, r4 and r3 can cyclize forming a 3-10 member ring comprising c, o, s, and/or n optionally substituted with one or more r3; and administering light therapy, such as a photodynamic therapy (pdt) light source.. .

 Thiobase compounds for photodynamic therapy patent thumbnailThiobase compounds for photodynamic therapy
A method of using a compound in a phototherapy procedure includes administering to a subject in need of treatment a therapeutically effective amount of a thio-substituted nucleobase, nucleoside, nucleotide, and/or analogs thereof; and exposing the administered compound to electromagnetic radiation.. .
Case Western Reserve University


 Therapeutic  photodynamic therapy for investigating curved portion patent thumbnailTherapeutic photodynamic therapy for investigating curved portion
The therapeutic apparatus for photodynamic therapy according to the present disclosure allows irradiation of light by unfolding tissues of the curved portion in the living body, using an unfolding part capable of being unfolded depending on the user's selection and the light irradiation part coupled to the unfolding part, there is an effect of allowing the use of the photodynamic therapy even in a portion that cannot be conventionally treated using the photodynamic therapy.. .

 Treatment of polypoidal chroidal vasculopathy patent thumbnailTreatment of polypoidal chroidal vasculopathy
Patients with polypoidal choroidal vasculopathy receive a combination of both (i) a photodynamic therapy, such as verteporfin and (ii) a non-antibody vegf antagonist.. .

 Therapy-progress-level monitoring device and method patent thumbnailTherapy-progress-level monitoring device and method
The provided is a therapy-progress-level monitoring device and a method thereof, providing information, in real time during a therapy, regarding the depth of extracellular photodynamic therapy. A photodynamic therapy progress-level monitoring device includes an irradiation unit configured to irradiate, with excitation light of a wavelength capable of exciting a photosensitive substance, a photosensitive substance distributed and sustainably supplied by vascular permeability in the extracellular fluid and the transcellular fluid of a living body; detection units configured to detect the fluorescence intensity produced when the photosensitive substance excited by a reaction between the excitation light and the photosensitive substance is inactivated into a ground state; a depth calculation unit configured to calculate in real time an indicator value estimating the volume or the depth of a therapy region by using the fluorescence intensity; and output units configured to output the indicator value in real time to a display or a storage..
Arai Medphoton Research Laboratories, Corporation


 Self-assembled pharmaceutical composition for photodynamic therapy patent thumbnailSelf-assembled pharmaceutical composition for photodynamic therapy
The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand a which is separated at a specific ph range, and a ligand b of which surface charge changes at a specific ph range and a method for manufacturing the same..
The Catholic University Of Korea Industry-academic Cooperation Foundation


Photosensitizer particles for medical imaging and/or photodynamic therapy


Disclosed herein are photosensitizer particle contrast agents suitable for medical imaging and/or photodynamic therapy. The photosensitizer particle contrast agent has a shell and a core encased by the shell.
National Chung Hsing University


Photodynamic therapy laser


A laser system including: a laser source operable to emit a first laser beam having a first operating wavelength and a second laser beam having a second operating wavelength; a fiber optic cable to guide and homogenize the first and second laser beams; an expander to increase the diameter of the first and second laser beams; a cylinder to guide the first and second laser beams and limit respective diameters of the first and second laser beams, wherein the cylinder is positioned after the expander on an optical path of the laser beam; a first optical system to collimate the first and second laser beams, wherein the optical system is positioned after the cylinder on the optical path of the first and second laser beams; a spot-size selector comprising a plurality of apertures, wherein the spot-size selector is positioned after the first optical system on the optical path of the first and second laser beams; and a second optical system to focus the first and second laser beams on a tissue of the patient.. .
Valeant Pharmaceuticals International, Inc.


Photodynamic therapy


There is herein described apparatus and a method for performing photodynamic therapy (pdt) and apparatus for performing pdt. More particularly, there is herein described a method of using pdt and associated apparatus over a prolonged period for the treatment of a range of therapies such as wound healing, cancer treatment (including both skin and internal body cancer) and psoriasis..
Ambicare Health Limited


Catheter/stent system for activation of photodynamic therapy within the catheter/stent system


A catheter/stent has multiple leds set in it along its length, connected to a voltage source such as a medical battery. The catheter/stent is inserted into the bile duct, to provide relief for tumor in growth that would otherwise obstruct the flow of bile through the bile duct.
University Of Rochester


Irradiation device


An irradiation device for insertion into an orifice of the body to provide photodynamic therapy comprises: a housing moulded from a resilient material and adapted to be fully inserted and secured in the orifice, the housing enclosing an led lamp system 22 and a power source 41 for powering the led lamp system 22; wherein the device is independently operational while located in the orifice; characterised in that: the housing comprises a first housing part 2 for holding the power source 41 and a second housing part 4 for holding the led lamp system 22, the first and second housing parts 2, 4 being separable and being preferably formed separately from the led lamp system 22; and in that the first housing part 2 consists of a chamber 6 for holding the power source 41 and an opening 26 into the chamber 6 is provided through a resilient opening part 8, wherein the chamber 6 is closed when the first housing part 2 is joined to the second housing part 4.. .
Photocure Asa


Methods and compositions for treating ocular glaucoma


The invention provides a photodynamic therapy-based method for treating ocular glaucoma. A photosensitizer, for example, a benzoporphyrin derivative photosensitizer, is administered to a mammal either having or at risk of developing ocular glaucoma.
Massachusetts Eye And Ear Infirmary


Methods of treating acne using dual panel photodynamic therapy lamp


A photodynamic therapy lamp includes two lamp modules comprising an array of leds. Each of the lamp modules is movable between a first position in which an angle between the lamp modules is from 157 degrees to 180 degrees, and a second position in which the angle between the lamp modules is from 50 degrees to 70 degrees..
Photocure Asa


Quantum-dot laser diode


Aspects of the present disclosure relate to the field of laser technology, specifically semiconductor lasers, and to novel biomedical applications of such lasers, including novel methods of photodynamic therapy. Exemplary embodiments of the present disclosure include a semiconductor laser diode having an active region having a gain medium with one or more ingaas/inas quantum dot layers; and wherein the laser diode can be arranged in operation to emit laser light having a central wavelength within spectral range of wave lengths.
University Of Dundee


Phthalocyanine probes and uses thereof


The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (<50 kda) protein or peptide or a small molecule that is conjugated to a phthalocyanine dye, such as irdye® 700dx..
Li-cor, Inc.


Use of a photosensitive agent capable of producing reactive oxygen species in the production of a drug for the photodynamic therapy of a disease related to stem cells, in vitro use, and pharmaceutical composition


The invention relates to the use of a photosensitive agent, or the precursor thereof, capable of producing reactive oxygen species (ros) in the production of a drug that can be used for the photodynamic therapy (pdt)-based treatment of a disease related to a patient's stem cells, preferably epidermal stem cells.. .
Consejo Superior De Investigaciones Cientificas


Halogenated compounds for photodynamic therapy


Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes.
Nanoquantum Sciences, Inc.


Nanoparticle therapy in cancer


Nanoparticles comprising a metal oxide and a platinum cluster having a height to base ratio greater than 1 and compositions containing the same are disclosed. Methods of using the nanoparticles in producing hydroxyl radicals and in photodynamic therapy, for example, in the treatment of hyperproliferative disease such cancer, are also disclosed..
The Regents Of The University Of Michigan


Cyanine dye compound and preparation method therefor, and dual-function agent for photodynamic therapy and preparation method therefor


Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver.
Zhejiang Hisun Pharmaceutical Co., Ltd.


Nonlinear optical photodynamic therapy (nlo-pdt) of the cornea


The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue..
The Regents Of The University Of California


Chlorin derivative useful in photodynamic therapy and diagnosis


The present invention relates to chlorin e4 sodium and a process for its preparation. Chlorin e4 sodium is suitable for use in photodynamic therapy, cytoluminescent therapy and photodynamic diagnosis, for example for treating or detecting a tumour.
Rmw Cho Group Limited


Methylene blue nanoparticle for bioimaging and photodynamic therapy and use thereof


The present invention relates to a methylene blue nanoparticle for bioimaging and photodynamic therapy, and a use thereof as a cancer therapeutic agent and a contrast agent. The methylene blue nanoparticle of the present invention for use as a topical cancer targeting photo therapeutic agent is composed of only a material of which the composition is clinically used or derived from human bodies, and thus a nanopreparation in which a barrier to clinical entry is low and the possibility of commercialization is very high, exhibits near-infrared fluorescence along with cancer targeting property, capacity of generating singlet oxygen and the like, and thus may be used for both bioimaging diagnosis such as optical imaging, and cancer targeting photodynamic therapy..
Korea Institute Of Science And Technology


Method and optical inhibition of photodynamic therapy


A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue.
The General Hospital Corporation D/b/a Massachusetts General Hospital


Water soluble anionic bacteriochlorophyll derivatives and their uses


The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological ph, preferably bchls having a group coo<->, cos<->, so3<->, po3<2->, cooh, cosh, so3h, and/or po3h2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic bchl molecule, for photodynamic therapy and diagnosis.. .
Yeda Research And Development Co. Ltd.


Irradiation device


An irradiation device for insertion into an orifice of the body for providing photodynamic therapy or diagnosis comprises: a housing adapted to be fully inserted and secured in the orifice, the housing enclosing an led lamp system and a power source for powering the led lamp system wherein the device is independently operational while located within the orifice.. .
Photocure Asa


Leukocytes as delivery cells for imaging and disease therapy


Theranostic methods are described herein, which are useful in diagnosing and/or treating infection, inflammation, and/or cancer. The methods utilize naturally-occurring leukocytes for in situ photodynamic therapy and imaging, and for the delivery of targeted therapies to the infection, inflammation, and/or cancer..

Preparation heteroatom doped multifunctional carbon quantum dot and application thereof


The present invention discloses a method for preparing heteroatom doped carbon quantum dot, and application thereof in fields of biomedicine, catalysts, photoelectric devices, etc. The various kinds of heteroatom doped carbon quantum dots are obtained by using a conjugated polymer as a precursor and through a process of high temperature carbonization.
Technical Institute Of Physics And Chemisty Of The Chinese Academy Of Sciences


Pyridinone compounds for use in photodynamic therapy


A compound which is a compound of formula (i) or any salt thereof: wherein r1 is a ci-c6 alkyl group, r2 is h or a ci-c6 alkyl group, r3 is h or a ci-c6 alkyl group, and n is an integer from 0 to 5.. .
University Of Exeter


Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof


The present disclosure includes and provides compositions comprising photosensitizing agents and their use in photodynamic therapy for the treatment of dermatological conditions.. .
Dermira, Inc.


Conjugate of a photosensitiser and chitosan and uses thereof


The present invention relates to novel chitosan-based conjugates, e.g. Nanocarriers, comprising a derivative of the biocompatible polymer chitosan conjugated to a photosensitising agent, and uses thereof in photochemical internalisation (pci) and photodynamic therapy (pdt).
Pci Biotech As


Apparatuses for positioning within an internal channel


Methods and apparatuses for positioning medical devices onto (or close to) a desired portion of the interior wall of an internal channel, such as for scan imaging, for photodynamic therapy and/or for optical temperature measurement. In one embodiment, a catheter assembly has a distal portion that can be changed from a configuration suitable for traversing the internal channel to another configuration suitable for scan at least a spiral section of the interior wall of an internal channel, such as an artery.
Advanced Cardiovascular Systems, Inc.


Dualistic substituted phthalocyanine zinc formula, process of separating the same and use thereof


The invention discloses a pharmaceutical formula used in photodynamic therapy (pdt) for cancer or precancerous lesions. The formula includes four components of disulfonic acid diphthaloyl iminomethyl dualistic substituted phthalocyanine zinc alkali salt.
Fuzhou University


Implementation of non-pathogenic bioluminescent bacteria as a sub-micron light emitting source for photo-dynamic therapy in the lungs


Systems and methods for treating a pathogenic bacterial infection are provided. The treatment may include introducing bioluminescent bacteria into a lung of a human or animal subject, and performing photodynamic therapy on the lung using light emitted from the bioluminescent bacteria..
Nomir Medical Technologies, Inc.


Abnormal electrical conduction blocking apparatus using photodynamic therapy (pdt)


There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer..
Keio University


Series of drugs using photofrin to catalyze decomposition of hydrogen peroxide


The present invention relates to a series of new drugs which refer to chemical series capable of catalyzing the decomposition of h2o2 to generate singlet oxygen (1o2). The drugs relate to therapeutic mechanisms, different from traditional photodynamic therapy, in which the specific affinity of photofrin to focus, such as tumors, vascular plaques and skin diseases is utilized.
Wuxi Zhaozhen Radiation Technology Co., Ltd.


Novel photoimmunoconjugates for use in photodynamic therapy


The photosensitizer is coupled to the binding protein via o6-alkylguanine-dna alkyltransferase (hagtm), a modified human dna repair protein.. .

Illuminator for photodynamic therapy


An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally u-shaped fluorescent tubes that are driven by electronic ballasts.
Dusa Pharmaceuticals, Inc.


Functionalized porous silicon nanoparticles and use thereof in photodynamic therapy


Disclosed are nanovectors of formula (i) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (i), (aa) is a porous silicon nanoparticle..
Ecole National Superieure De Chimie De Montpellier


Guided photodynamic therapy


A photodynamic therapy (pdt) system with an elongated interventional device (idv) with a bundle of optical fibers (f1, f2, f3) forming respective light exit ports which can be individually accessed. The bundle has an optical shape sensing fiber (oss), e.g.
Koninklijke Philips N.v.


Ultrafine nanoparticles as multimodal contrast agent


The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions.
Universite Joseph Fourier


Handheld device for delivering photodynamic therapy


The present invention relates to a handheld dental device that provides photodynamic therapy. The device of the present invention may have an elongated housing; an applicator tip extending from the distal end of the housing; wherein the applicator tip has a lumen defined by a wall; an optic fiber extending through the lumen of the applicator tip; at least one power source attached to or residing within the housing; at least one light source that provides light to the optic fiber and emits a wavelength that ranges from about 650 nm to about 1400 nm; and at least one oxygen source that provides oxygen to a passage that communicates with the oxygen source and the applicator tip.
The Forsyth Institute


Device for photodynamical therapy of cancer


A method and device for photodynamic therapy for treating cancer. The method includes: providing a photodynamic therapeutic device for treating cancer.

Photodynamic therapy for tumors with localized delivery


A system for treatment of tumors includes a vessel having a photosensitizing agent therein, a delivery device for communicating the photosensitizing agent from the vessel to tumor tissue, a light source for radiating the tumor tissue after the delivery device has delivered the photosensitizing agent to the tumor tissue, a catheter having at least one inflatable balloon positioned thereon, and a fluid source that repeatedly inflates and at least partially deflates the inflatable balloon such that a resecting outer surface of the balloon contacts the radiated tumor tissue and resects the tissue.. .

Photoacoustic contrast agent having lipid particle containing silicon naphthalocyanine analog


A conventional silicon naphthalocyanine-containing liposome is required to incorporate a dye dispersed therein for use in photodynamic therapy, and is thus low in dye content and also low in photoacoustic signal. According to a lipid particle containing a silicon naphthalocyanine analog, in which the ratio a/b of an absorption coefficient a at a first absorption local maximum to an absorption coefficient b at a second absorption local maximum in a range from 700 nm to 800 nm is 5.0 or less, the dye content in the lipid particle can be increased and the photoacoustic signal intensity can be improved..
Canon Kabushiki Kaisha


De novo synthesis of bacteriochlorins


To produce the bacteriochlorin, wherein r is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid.

Synthesis of upconversion nanocomposites for photodynamic therapy


The present invention refers to a composite material including at least one upconversion particulate material that under near infrared (nir) irradiation emits visible light of a wavelength between 380 and 740 nm, and at least one semiconductor particulate material that can absorb the visible light emitted by the at least one upconversion particulate material and upon absorbance generates reactive species, wherein the at least one upconversion particulate material and the at least one semiconductor particulate material are physiologically acceptable. The upconversion particulate material can comprises nayf4 doped with a one rare earth metal.

Immunogenic treatment of cancer


The present invention provides an immunomodulator for use in the treatment and/or control of a neoplastic disease in a patient intended to undergo immunogenic cell death therapy simultaneously, separately or sequentially with administration of the immunomodulator. The therapy can be selected from microwave irradiation, targeted radiotherapy, embolization, cryotherapy, ultrasound, high intensity focused ultrasound, cyberknife, hyperthermia, radiofrequency ablation, cryoablation, electrotome heating, hot water injection, alcohol injection, embolization, radiation exposure, photodynamic therapy, laser beam irradiation, and combinations thereof..

Compositions for photodynamic therapy chemically modified to increase epithelia penetration and cellular bioavailability


The present invention describes a photodynamic prodrug, i.e., a substituted 4-thiothymidine (4-tt), which is able to cross the body's epithelia tissues such as the skin, oral cavity, nasal cavity, pulmonary tract, digestive tract, and blood-brain barrier, including the use of such a prodrug in a topical application for the treatment of skin hyperplasias, including skin cancer, psoriasis, keloids, actinic keratosis, and the like.. .

Catheter for performing photodynamic ablation of cardiac muscle tissue via photochemical reaction


This invention provides a catheter used for blocking abnormal conduction in the cardiac muscle using photodynamic therapy or treating arrhythmia and a method for evaluating the therapeutic effects of the catheter. The catheter has a structure that freely bends at its end, which is used for performing photodynamic ablation of cardiac muscle tissue via photochemical reactions in the blood vessel or cardiac lumen.

Compositions and methods for reducing photosensitivity associated with photodynamic therapy


The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (pdt). The compositions and methods of the present method employ porphyrin complexing molecules as agents for reducing photosensitivity..

Halogenated compounds for photodynamic therapy


Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes.

Halogenated compounds for photodynamic therapy


Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes.

Multispectral therapeutic light source


A light source apparatus including light spectrum-converting materials that emit light primarily over large portions of the 360 nm-480 nm and the 590-860 nm spectral range is provided. This apparatus provides a cooled, high-luminance, high-efficiency light source that can provide a broader spectrum of light within these spectral ranges than has been cost-practical by using many different dominant peak emission leds.

Halogenated compounds for photodynamic therapy


Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes.

Immune-stimulating photoactive hybrid nanoparticles


Provides is a therapeutic technology that combines the phototoxic and immune-stimulating ability of photodynamic therapy with the widespread effectiveness of the immune system to reduce the viability of such as cancer cells and tumors. The nanoparticle compositions of the disclosure combine an immunostimulant with a photosensitizer using a nanoparticle delivery platform.

Method of targeting hydrophobic drugs to vascular lesions


This invention relates to the targeted delivery of hydrophobic drugs or combinations of hydrophobic drugs with photodynamic therapy agents to vascular lesions by complexation of the drugs to blood serum lipoproteins, which have an affinity for and accumulate in such vascular lesions.. .

Therapeutic agent for allergic rhinitis


Provided is a therapeutic agent capable of treating allergic rhinitis in a safe, simple, and noninvasive manner substantially without side effects and physical distress to patients. Provided is a therapeutic agent for allergic rhinitis for 5-aminolevulinic acid-based photodynamic therapy (ala-pdt) comprising 5-aminolevulinic acid (ala) or a derivative thereof, or a salt of the 5-aminolevulinic acid or the derivative as an active ingredient, and used in ala-pdt in which light having a wavelength of 400 nm to 700 nm is irradiated; and particularly provided is a therapeutic agent for allergic rhinitis in a locally applied solution form, a water-soluble ointment-dissolved form, a jelly-dissolved form, or the like.

Radioisotope-photodynamic therapy for cancer treatment


The present invention provides compositions and methods for radioisotope-photodynamic therapy for treating cancer. Specifically, the invention relates to compositions and methods for administering a radiation emitter, a rare-earth doped down-converting nanophosphor and a photosensitizer for treating cancer..

Metallocorroles


Metallocorrole complexes of third row transition metals (see formula i below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of oleds.

Methods and compositions for treating conditions of the eye


Provided are methods and compositions for treating ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of, for example, a photodynamic therapy (pdt)-based approach can be enhanced by combining the pdt with an anti-fasl factor, for example, an anti-fasl neutralizing antibody..

Methods and compositions for treating conditions of the eye


Provided are methods and compositions for the photodynamic therapy (pdt) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the pdt method can be enhanced by combining the pdt with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor.

Novel phthalocyanine derivatives for therapeutic use


There are described phthalocyanine derivates, the pharmaceutical compositions and the medical devices that contain them, possibly in combination with chelating agents, such as edta, useful for treating, by means of photodynamic therapy, diseases characterised by cellular hyperproliferation, microbial infections caused by gram− bacteria, gram+ bacteria and fungi, and for treating various types of infected and non-infected ulcers.. .

Use of an agent that restores tissue perfusion and oxygenation


The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects.

Compositions and methods for cancer treatment using targeted carbon nanotubes


Compositions for detecting and/or destroying cancer tumors and/or cancer cells via photodynamic therapy are disclosed, as well as methods of use thereof. The compositions comprise a linking protein or peptide attached to or otherwise physically associated with a carbon nanotube to form a targeted protein-carbon nanotube complex..

In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles


Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (cpnp).

Rgd-containing peptidomimetics and uses thereof


The invention provides rgd-containing cyclic peptidomimetics; conjugates of said peptidomimetics and a moiety of a payload selected from fluorescent probes, photosensitizers, chelating agents, or cytotoxic agents; and pharmaceutical compositions comprising these conjugates. The conjugates of the invention are useful both for diagnostic purposes and treatment of various diseases, disorders and conditions.

Photodynamic therapy using photosensitizing agent or 5-aminolevulinic acid


It is to provide photodynamic therapy (pdt) and photodynamic diagnosis (pdd) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing pdt and pdd targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin ix, etc.) or alas such as 5-aminolevulinic acid (ala), ala methyl ester, ala ethyl ester, ala propyl ester, ala butyl ester, ala pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm..

Series of drugs using photofrin to catalyze decomposition of hydrogen peroxide


The present invention relates to a series of new drugs which refer to chemical series capable of catalyzing the decomposition of h2o2 to generate singlet oxygen (1o2). The drugs relate to therapeutic mechanisms, different from traditional photodynamic therapy, in which the specific affinity of photofrin to focus, such as tumors, vascular plaques and skin diseases is utilized.

New 5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis


And salts thereof, where r1 is an oxime or an alkylated oxime; the alkylated oxime comprises a linear or branched alkyl group of length c1 to c5; and r2 are each independently (a) an unsubstituted or substituted linear or branched alkyl group of chain length c1-7, (b) an aryl substituted alkyl group, where the aryl group is substituted, (c) an alkoxy substituted alkyl group, where the alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, or (d) an h atom, where the substituents in (a) and (b) are hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups. The compounds may be used as a medicament..

Dual panel photodynamic therapy lamp


A photodynamic therapy lamp includes two lamp modules comprising an array of leds. Each of the lamp modules is movable between a first position in which an angle between the lamp modules is from 157 degrees to 180 degrees, and a second position in which the angle between the lamp modules is from 50 degrees to 70 degrees..

Photodynamic therapy or diagnostic agent, using infrared-spectrum light


It is intended to provide a therapeutic and/or diagnostic agent that can be used in photodynamic therapy (pdt) or photodynamic diagnosis (pdd) capable of utilizing infrared-spectrum light such as near-infrared light (nir), infrared light, or far-infrared light, which attains a deep body penetration. The present invention provides a photodynamic therapeutic or diagnostic agent or a photodynamic therapeutic or diagnostic kit for cancer or infectious disease, comprising: a particle (e.g., a lanthanide particle) that emits upconversion luminescence by infrared-spectrum light such as near-infrared light having a wavelength of 0.7 μm to 2.5 μm; and a photosensitizer (e.g., porphyrin) or a 5-aminolevulinic acid group..

Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and use thereof


The present invention provides a photodynamic therapy to a patient having at least one tumor comprising the steps of: administering a compound of formula 6 (wherein r1 and r2 are defined as the above) in a pharmaceutically acceptable carrier to the patient; waiting for a sufficient time to allow the administered compound to be taken up by a target tissue having the at least one tumor; and irradiating a region of the patient containing the target tissue, wherein growth of the tumor is inhibited.. .

Light diffuser and process for producing the same


A light diffuser, which is particularly suitable for introducing diffuse light into a tissue, is produced by interpenetration of a diffuser material in a liquid state into a boundary layer of a porous shaping material, by which process a diffuser surface is formed having a surface structure which represents essentially a negative of the pore structure of the shaping material and includes undercut structures induced by a surface tension. The light diffuser is e.g.

Continuous low irradiance photodynamic therapy system and method


Systems and methods are providing for treating a patient with continuous low irradiance photodynamic therapy. A disclosed method includes applying a photosensitizer to the patient; applying a conformable skin facing light applicator to the patient; and providing continuous low irradiance photodynamic therapy through the light applicator.

Diagnostic device, therapeutic device, and uses thereof


Apparatus, method, computing devices, and computer programs related to photodiagnosis and photodynamic therapy, methods of use thereof, and a method for detecting abnormal tissue, are provided.. .

Use of fusarochromanone and its derivatives in the diagnosis and treatment of cancer and other diseases


A method of photodynamic therapy to treat diseased cells in an animal is generally provided. According to the method, 5-amino-2,2-dimethyl-6-[3′-(r,s)amino-4′-hydroxy-butan-1-one]-2,3-dihydro-4h-1-benzopyran-4-one or an analog thereof is administered to the animal such that the 5-amino-2,2-dimethyl-6-[3′-(r,s)amino-4′-hydroxy-butan-1-one]-2,3-dihydro-4h-1-benzopyran-4-one or an analog thereof accumulates in the diseased cells.

Two-way photodynamic therapy stereo colposcope for diagnosing and treating diseases of the female genital tract


A stereo colposcope having variable linearity filter systems for both the excitation step and the suppression step, and can be used universally with any fluorescent compound or drug, as is the case of photodynamic diagnosis (pdd). The colposcope is a two-way colposcope because the treatment can be administered by an optical system or by a light-producing radio-frequency electrical current with a diathermic effect which facilitates photodynamic treatment.

Water soluble anionic bacteriochlorophyll derivatives and their uses


The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological ph, preferably bchls having a group coo<−>, cos<−>, so3<−>, po3<2−>, cooh, cosh, so3h, and/or po3h2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic bchl molecule, for photodynamic therapy and diagnosis.. .

Nonlinear optical photodynamic therapy (nlo-pdt) of the cornea


The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue..

Method for treating a patient via photodynamic therapy comprising a macromolecular capsule


A composition for photodynamic therapy including a polymer capsule having a diameter of about 10 nm to about 2000 nm synthesized by copolymerization of a flat aromatic compound represented by formula 1 (see the specification) and an organic compound represented by formula 2 (see the specification).. .

Nanoprobe comprising gold colloid nanoparticles for multimodality optical imaging of cancer and targeted drug delivery for cancer


The present invention is directed to a nanoparticle loaded with a light sensitive molecule and a method of preparing the nanoparticle, wherein the nanoparticle is a colloidal gold nanoparticle and the light sensitive molecule is non-covalently adsorbed to the surface of the nanoparticle. The present invention is also directed to a nanoprobe comprising the nanoparticle and further comprising a targeting moiety covalently coupled to the surface of the nanoparticle.

Catheter for photodynamic therapy


The present invention provides a multi-functional catheter that can be used to irrigate a treatment site located within a body cavity, to suction waste materials from the treatment site, and to deliver a treatment composition in a generally uniform distribution pattern onto the treatment site. The present invention also provides a method to use this multi-functional catheter for various applications including medical applications (e.g., photodynamic therapy treatment of chronic recurrent sinusitis)..

Photodynamic therapy system, device and associated treatment


As one example, a photodynamic therapy system can include a flexible panel comprising a plurality of light sources distributed across a conformable light delivery surface thereof. The plurality of light sources can be configured to provide a treatment light to achieve a desired therapeutic effect at a predetermined distance from the light delivery surface.

Focal photodynamic therapy methods


Improved methods of treating prostate cancer by vascular-targeted photodynamic therapy, and improved methods of planning treatment, are presented using a light density index to plan and guide effective treatment.. .

Modelling of the action of an optical fibre in photodynamic therapy treatment, and assistance in the planning of said treatment


A method (200) for planning of a treatment with photodynamic therapy for a patient includes performing a measurement (230) of the volume of the treatment area by volume reconstruction from digital processing of contours inputted directly into a series of digital images of the area being treated, then determining (250) by calculating the number of optical fibers used, their position relative to the brachytherapy grid and their insertion length which optimizes the correspondence of a total theoretical action volume calculated with the measured volume of the treatment area. The total theoretical action volume is calculated based on the position of each fiber, and an elementary theoretical action volume of a fiber corresponding to the volume of a cylinder with predetermined action radius r, and height corresponding to the insertion length of the fiber..

Novel compositions and uses of anti-hypertension agents for cancer therapy


Methods and compositions for improving the delivery and/or efficacy of a therapy (e.g., a cancer therapy) are disclosed. In one embodiment, methods and compositions for treating or preventing a cancer (e.g., a solid tumor such as a desmoplastic tumor) by administering to a subject an anti-hypertensive agent, as a single agent or in combination with a microenvironment modulator and/or a therapy, e.g., a cancer therapy (for example, a therapeutic agent or therapy, including immunotherapy (e.g., antibodies, vaccine, cell-based), nanotherapeutics, radiation therapy, photodynamic therapy, low molecular weight chemotherapeutics, molecularly targeted therapeutics and/or oxygen radical) are disclosed..

Photodynamic therapy laser


A laser system including: a laser source operable to emit a first and a second laser beam having first and second operating wavelengths, respectively; a fiber optic cable to guide and homogenize the laser beams; an expander to increase the diameter of the laser beams; a cylinder to guide the laser beams and limit respective diameters of the first and second laser beams, wherein the cylinder is positioned after the expander on an optical path of the laser beam; a first optical system to collimate the laser beams, wherein the optical system is positioned after the cylinder on the optical path of the laser beams; a spot-size selector comprising a plurality of apertures, wherein the spot-size selector is positioned after the first optical system on the optical path of the laser beams; and a second optical system to focus the laser beams on a tissue of the patient.. .

Renilla/gaussia transfected cells as a light source for in-situ photodynamic therapy of cancer


A method for photodynamic therapy treatment of cancerous cells and tissue is provided. The method comprises administering tumor-trophic cells expressing a luminescent protein to a subject.

Halogenated compounds for photodynamic therapy


Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes.

Acne therapeutic agent and sebum secernent inhibitor which comprise indole-3-alkylcarbo xylicacid, and kits for photodynamic therapy containing the same


The present invention relates to novel uses of indole-3-alkylcarboxylic acid and derivatives thereof as a photosensitizer for the treatment of acne or for the inhibition of sebum secretion. More particularly, the present invention is directed to a photosensitizer for photodynamic therapy, a photodynamic therapy kit and photodynamic therapeutic composition comprising thereof, which contain indole-3-alkylcarboxylic acid being activated by light.

Methods and devices for crosslinking of corneal collagen and for treatment of disorders of the eye


Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye.

Photolabile caged transition metal complexes and methods of using the same


Along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.. .

Pheophorbide-alpha conjugates and their uses


The present invention relates to a pheophorbide-α conjugate or its salt, solvate or hydrate. The pheophorbide-α conjugate of the present invention exhibiting fluorescence upon its introduction into cells and degradation inhibits the survival of various cancer cells.

Multifunctional nanoplatforms for fluorescence imaging and photodynamic therapy developed by post-loading photosensitizer and fluorophore to polyacrylamide nanoparticles


A composition comprising paa nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.. .



Photodynamic Therapy topics:
  • Photodynamic Therapy
  • Sensitizer
  • Fluorescence
  • Cancer Cells
  • Cancer Cell
  • Antibodies
  • Antimicrobial
  • Therapeutics
  • Hypertensive
  • Hypertension
  • Desmoplastic
  • Immunotherapy
  • Radiation Therapy
  • Digital Processing
  • Optical Fiber


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