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Photodynamic Therapy patents

      

This page is updated frequently with new Photodynamic Therapy-related patent applications.




 Apparatus and  multiwavelength photodynamic therapy patent thumbnailApparatus and multiwavelength photodynamic therapy
A method for treating a condition in a tissue, includes the steps: (1) providing a ps within the tissue; (2) irradiating the tissue containing the ps with a first light of a first wavelength; and (3) irradiating the tissue containing the ps with a second light of a second wavelength so as to treat the condition in the tissue, wherein: (a) the ps absorbs light at the first wavelength and the second wavelength; and (b) the second light is more strongly absorbed by the tissue than the first light or vice versa, so as to achieve a predetermined absorbed photon density gradient. An apparatus for conducting the method includes first and second light sources, a power supply, a focusing device, and a controller which adjusts light emission such that i(d)=i(λ1 at d=0)×exp (μeff (λ1)×d)+i(λ2 at d=0)×exp (μeff(λ2)χd)..
Theralase Technologies, Inc.


 Methods for cross-linking corneal collagen with verteporfin for the treatment of disorders of the eye patent thumbnailMethods for cross-linking corneal collagen with verteporfin for the treatment of disorders of the eye
Described are compositions and methods of using verteporfin-based photodynamic therapy (pdt) to increase the biomechanical strength of the cornea. More particularly, described herein are compositions and methods for cross-linking collagen in corneal tissue which are useful in the treatment of corneal ectatic disorders..
Massachusetts Eye And Ear Infirmary


 Metal-glycoprotein complexes and photodynamic therapy of immune privileged sites with same patent thumbnailMetal-glycoprotein complexes and photodynamic therapy of immune privileged sites with same
Compositions of the invention include glycoproteins, such as transferrin, and metal-based coordination complexes, which are preferably chemotherapeutic compounds and more preferably tunable photodynamic compounds. The compositions are useful as in vivo diagnostic agents, and as therapeutic agents for treating or preventing diseases including those that involve hyperproliferating cells in their etiology, such as cancer.
Theralase Technologies, Inc.


 Lung targeting dual drug delivery system patent thumbnailLung targeting dual drug delivery system
The american cancer society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the united states of which 219,440 would be lung and bronchus related. The standard treatments for nsclc include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer.
Rutgers, The State University Of New Jersey


 Methods and compositions for treating conditions of the eye patent thumbnailMethods and compositions for treating conditions of the eye
Provided are methods and compositions for treating ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example neovascular age-related macular degeneration. The selectivity and sensitivity of, for example, a photodynamic therapy (pdt)based approach can be enhanced by combining the pdt with an anti-fasl factor, for example, an anti-fasl neutralizing antibody..
Massachusetts Eye And Ear Infirmary


 Uniform core-shell tio2 coated upconversion nanoparticles and use thereof patent thumbnailUniform core-shell tio2 coated upconversion nanoparticles and use thereof
An upconversion nanoparticle (ucn) coated with a layer of semiconductor material is disclosed. The ucn core acts as a nanotransducer to convert near infrared (nir) to visible and/or ultraviolet (uv) light while the semiconductor shell serves as a photocatalyst.
National University Of Singapore


 Dual panel photodynamic therapy lamp patent thumbnailDual panel photodynamic therapy lamp
A photodynamic therapy lamp includes two lamp modules comprising an array of leds. Each of the lamp modules is movable between a first position in which an angle between the lamp modules is from 157 degrees to 180 degrees, and a second position in which the angle between the lamp modules is from 50 degrees to 70 degrees..
Photocure Asa


 Combination artemisinin and chemiluminescent photodynamic therapy and uses therefor patent thumbnailCombination artemisinin and chemiluminescent photodynamic therapy and uses therefor
photodynamic therapy-based methods of treating diseases such as cancer and malaria are disclosed. These methods include administering 5-aminolevulinic acid (ala), luminol and artemisinin (art).
Washington University


 Composition for prevention or treatment of treatment-resistant cancer patent thumbnailComposition for prevention or treatment of treatment-resistant cancer
[solution] a preventive or therapeutic composition for a therapy-resistant cancer having therapy-resistant cancer cells, which is for use in photodynamic therapy, wherein the composition comprises alas.. .

 Pulse photodynamic treatment of skin conditions patent thumbnailPulse photodynamic treatment of skin conditions
A pulse photodynamic therapy (or pulse pdt) treatment of skin complaints is described herein. The skin complaint being treated can be actinic keratosis (ak) or a basal cell carcinoma (bcc)..
Galderma Research & Development


Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers

Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering rna (sirna) or microrna, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different sirnas.
The University Of North Carolina At Chapel Hill

Pulse photodynamic treatment of acne

A pulse photodynamic therapy (or pulse pdt) treatment of acne is described herein.. .
Galderma Research & Development

Device and use of photodynamic therapy

An apparatus including a light source provides for intracranial treatment of a tissue region of a brain of a patient. The intracranial treatment apparatus comprises an outer shaft having a proximal end and a distal end for positioning within the tissue region of the brain.

Photodynamic therapy for treating clostridium difficile infection using chitosan and tetracycline

Effective photodynamic therapy (pdt) against c. Difficile is provided using a composition including chitosan and tetracycline..
Catholic University Industry Academic Cooperation Foundation

Pulse photodynamic treatment of photodamaged skin

A pulse photodynamic therapy (or pulse pdt) treatment of photodamaged skin is described.. .
Galderma Research & Development

Radioluminescent compound for radiotherapy and deep photodynamic therapy and device for deep photodynamic therapy

A radioluminescent compound for radiotherapy and deep photodynamic therapy (deep pdt), the radioluminescent compound including a molecular conjugate made up of a radioluminescent molecule and one photosensitizer, the radioluminescent molecule being suitable for absorbing an x-ray with energy higher than an absorption threshold and for emitting luminescent radiation in the visible domain, and the photosensitizer being suitable for absorbing the luminescent radiation and producing singlet oxygen. The radioluminescent compound is made up of a molecule of lanthanide chloride (lncl3); the photosensitizer is selected among the following photosensitizers: al(iii)phthalocyanine, mthpc, chlorin e6 (ce6), hypericin, hypocrellin, nile blue, oxazine 170, oxazine 1, protoporphyrin ix, 7-methoxycoumarin-4-acetic acid, bacteriochlorophyll, and auramin; and the photosensitizer is selected such as to maximize the energy transfer between an x-ray absorbed by the radioluminescent lanthanide 2 and the photosensitizer in order to produce singlet oxygen..
Synchrotron Soleil

Space, luminous ceiling conducting photodynamic therapy

A space for conducting photodynamic therapy (pdt) for treatment of skin diseases, especially for treatment of superficial skin tumors such as actinic keratoses, basal cell carcinomas, and initial carcinomas, wherein an active ingredient is applied to a skin area to be treated in order to form porphyrins and irradiation with light is conducted to form singlet oxygen based on the porphyrins in order to destroy diseased skin cells, wherein the space has side walls, a ceiling, and a floor, as well as at least two lighting fixtures, which are separated from one another by at least 50 cm and illuminate at least a subregion of the space, wherein there is an illuminance of at least 8,000 lux at every point in the subregion and the subregion has horizontal dimensions of at least 1 m2 and a vertical height of at least 40 cm. This invention also relates to a luminous ceiling system and method for conducting pdt..
Swiss Red Ag

Upconverting nanoparticles

Provided herein are lanthanide-containing upconverting nanoparticles, methods of their preparation, compositions, and methods of using the same. The polymers and compositions provided herein may be used, for example, in photodynamic therapy..

Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy

Urea-based photosensitizers, which target prostate-specific membrane antigen (psma) for imaging and targeted therapy of psma-expressing tumors and cancers are disclosed.. .
The Johns Hopkins University

Methods for use of small molecule activators of hem-y / protoporphyrinogen oxidase (ppo)

Wherein r1 is h, alkyl, aryl, heteroaryl, r2 is h, halogen, alkyl, aryl, heteroaryl, r3 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r4 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r5 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r6 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r7 is h, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, r8 is —cr3, o, s, wherein r5 and r6, r7 and r6, r5 and r4, r4 and r3 can cyclize forming a 3-10 member ring comprising c, o, s, and/or n optionally substituted with one or more r3; and administering light therapy, such as a photodynamic therapy (pdt) light source.. .

Thiobase compounds for photodynamic therapy

A method of using a compound in a phototherapy procedure includes administering to a subject in need of treatment a therapeutically effective amount of a thio-substituted nucleobase, nucleoside, nucleotide, and/or analogs thereof; and exposing the administered compound to electromagnetic radiation.. .
Case Western Reserve University

Therapeutic photodynamic therapy for investigating curved portion

The therapeutic apparatus for photodynamic therapy according to the present disclosure allows irradiation of light by unfolding tissues of the curved portion in the living body, using an unfolding part capable of being unfolded depending on the user's selection and the light irradiation part coupled to the unfolding part, there is an effect of allowing the use of the photodynamic therapy even in a portion that cannot be conventionally treated using the photodynamic therapy.. .

Treatment of polypoidal chroidal vasculopathy

Patients with polypoidal choroidal vasculopathy receive a combination of both (i) a photodynamic therapy, such as verteporfin and (ii) a non-antibody vegf antagonist.. .

Therapy-progress-level monitoring device and method

The provided is a therapy-progress-level monitoring device and a method thereof, providing information, in real time during a therapy, regarding the depth of extracellular photodynamic therapy. A photodynamic therapy progress-level monitoring device includes an irradiation unit configured to irradiate, with excitation light of a wavelength capable of exciting a photosensitive substance, a photosensitive substance distributed and sustainably supplied by vascular permeability in the extracellular fluid and the transcellular fluid of a living body; detection units configured to detect the fluorescence intensity produced when the photosensitive substance excited by a reaction between the excitation light and the photosensitive substance is inactivated into a ground state; a depth calculation unit configured to calculate in real time an indicator value estimating the volume or the depth of a therapy region by using the fluorescence intensity; and output units configured to output the indicator value in real time to a display or a storage..
Arai Medphoton Research Laboratories, Corporation

Self-assembled pharmaceutical composition for photodynamic therapy

The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand a which is separated at a specific ph range, and a ligand b of which surface charge changes at a specific ph range and a method for manufacturing the same..
The Catholic University Of Korea Industry-academic Cooperation Foundation

Photosensitizer particles for medical imaging and/or photodynamic therapy

Disclosed herein are photosensitizer particle contrast agents suitable for medical imaging and/or photodynamic therapy. The photosensitizer particle contrast agent has a shell and a core encased by the shell.
National Chung Hsing University

Photodynamic therapy laser

A laser system including: a laser source operable to emit a first laser beam having a first operating wavelength and a second laser beam having a second operating wavelength; a fiber optic cable to guide and homogenize the first and second laser beams; an expander to increase the diameter of the first and second laser beams; a cylinder to guide the first and second laser beams and limit respective diameters of the first and second laser beams, wherein the cylinder is positioned after the expander on an optical path of the laser beam; a first optical system to collimate the first and second laser beams, wherein the optical system is positioned after the cylinder on the optical path of the first and second laser beams; a spot-size selector comprising a plurality of apertures, wherein the spot-size selector is positioned after the first optical system on the optical path of the first and second laser beams; and a second optical system to focus the first and second laser beams on a tissue of the patient.. .
Valeant Pharmaceuticals International, Inc.

Photodynamic therapy

There is herein described apparatus and a method for performing photodynamic therapy (pdt) and apparatus for performing pdt. More particularly, there is herein described a method of using pdt and associated apparatus over a prolonged period for the treatment of a range of therapies such as wound healing, cancer treatment (including both skin and internal body cancer) and psoriasis..
Ambicare Health Limited

Catheter/stent system for activation of photodynamic therapy within the catheter/stent system

A catheter/stent has multiple leds set in it along its length, connected to a voltage source such as a medical battery. The catheter/stent is inserted into the bile duct, to provide relief for tumor in growth that would otherwise obstruct the flow of bile through the bile duct.
University Of Rochester

Irradiation device

An irradiation device for insertion into an orifice of the body to provide photodynamic therapy comprises: a housing moulded from a resilient material and adapted to be fully inserted and secured in the orifice, the housing enclosing an led lamp system 22 and a power source 41 for powering the led lamp system 22; wherein the device is independently operational while located in the orifice; characterised in that: the housing comprises a first housing part 2 for holding the power source 41 and a second housing part 4 for holding the led lamp system 22, the first and second housing parts 2, 4 being separable and being preferably formed separately from the led lamp system 22; and in that the first housing part 2 consists of a chamber 6 for holding the power source 41 and an opening 26 into the chamber 6 is provided through a resilient opening part 8, wherein the chamber 6 is closed when the first housing part 2 is joined to the second housing part 4.. .
Photocure Asa

Methods and compositions for treating ocular glaucoma

The invention provides a photodynamic therapy-based method for treating ocular glaucoma. A photosensitizer, for example, a benzoporphyrin derivative photosensitizer, is administered to a mammal either having or at risk of developing ocular glaucoma.
Massachusetts Eye And Ear Infirmary

Methods of treating acne using dual panel photodynamic therapy lamp

A photodynamic therapy lamp includes two lamp modules comprising an array of leds. Each of the lamp modules is movable between a first position in which an angle between the lamp modules is from 157 degrees to 180 degrees, and a second position in which the angle between the lamp modules is from 50 degrees to 70 degrees..
Photocure Asa

Quantum-dot laser diode

Aspects of the present disclosure relate to the field of laser technology, specifically semiconductor lasers, and to novel biomedical applications of such lasers, including novel methods of photodynamic therapy. Exemplary embodiments of the present disclosure include a semiconductor laser diode having an active region having a gain medium with one or more ingaas/inas quantum dot layers; and wherein the laser diode can be arranged in operation to emit laser light having a central wavelength within spectral range of wave lengths.
University Of Dundee

Phthalocyanine probes and uses thereof

The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (<50 kda) protein or peptide or a small molecule that is conjugated to a phthalocyanine dye, such as irdye® 700dx..
Li-cor, Inc.

Use of a photosensitive agent capable of producing reactive oxygen species in the production of a drug for the photodynamic therapy of a disease related to stem cells, in vitro use, and pharmaceutical composition

The invention relates to the use of a photosensitive agent, or the precursor thereof, capable of producing reactive oxygen species (ros) in the production of a drug that can be used for the photodynamic therapy (pdt)-based treatment of a disease related to a patient's stem cells, preferably epidermal stem cells.. .
Consejo Superior De Investigaciones Cientificas

Halogenated compounds for photodynamic therapy

Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes.
Nanoquantum Sciences, Inc.

Nanoparticle therapy in cancer

Nanoparticles comprising a metal oxide and a platinum cluster having a height to base ratio greater than 1 and compositions containing the same are disclosed. Methods of using the nanoparticles in producing hydroxyl radicals and in photodynamic therapy, for example, in the treatment of hyperproliferative disease such cancer, are also disclosed..
The Regents Of The University Of Michigan

Cyanine dye compound and preparation method therefor, and dual-function agent for photodynamic therapy and preparation method therefor

Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver.
Zhejiang Hisun Pharmaceutical Co., Ltd.

Nonlinear optical photodynamic therapy (nlo-pdt) of the cornea

The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue..
The Regents Of The University Of California

Chlorin derivative useful in photodynamic therapy and diagnosis

The present invention relates to chlorin e4 sodium and a process for its preparation. Chlorin e4 sodium is suitable for use in photodynamic therapy, cytoluminescent therapy and photodynamic diagnosis, for example for treating or detecting a tumour.
Rmw Cho Group Limited

Methylene blue nanoparticle for bioimaging and photodynamic therapy and use thereof

The present invention relates to a methylene blue nanoparticle for bioimaging and photodynamic therapy, and a use thereof as a cancer therapeutic agent and a contrast agent. The methylene blue nanoparticle of the present invention for use as a topical cancer targeting photo therapeutic agent is composed of only a material of which the composition is clinically used or derived from human bodies, and thus a nanopreparation in which a barrier to clinical entry is low and the possibility of commercialization is very high, exhibits near-infrared fluorescence along with cancer targeting property, capacity of generating singlet oxygen and the like, and thus may be used for both bioimaging diagnosis such as optical imaging, and cancer targeting photodynamic therapy..
Korea Institute Of Science And Technology

Method and optical inhibition of photodynamic therapy

A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue.
The General Hospital Corporation D/b/a Massachusetts General Hospital

Water soluble anionic bacteriochlorophyll derivatives and their uses

The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological ph, preferably bchls having a group coo<->, cos<->, so3<->, po3<2->, cooh, cosh, so3h, and/or po3h2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic bchl molecule, for photodynamic therapy and diagnosis.. .
Yeda Research And Development Co. Ltd.

Irradiation device

An irradiation device for insertion into an orifice of the body for providing photodynamic therapy or diagnosis comprises: a housing adapted to be fully inserted and secured in the orifice, the housing enclosing an led lamp system and a power source for powering the led lamp system wherein the device is independently operational while located within the orifice.. .
Photocure Asa

Leukocytes as delivery cells for imaging and disease therapy

Theranostic methods are described herein, which are useful in diagnosing and/or treating infection, inflammation, and/or cancer. The methods utilize naturally-occurring leukocytes for in situ photodynamic therapy and imaging, and for the delivery of targeted therapies to the infection, inflammation, and/or cancer..

Preparation heteroatom doped multifunctional carbon quantum dot and application thereof

The present invention discloses a method for preparing heteroatom doped carbon quantum dot, and application thereof in fields of biomedicine, catalysts, photoelectric devices, etc. The various kinds of heteroatom doped carbon quantum dots are obtained by using a conjugated polymer as a precursor and through a process of high temperature carbonization.
Technical Institute Of Physics And Chemisty Of The Chinese Academy Of Sciences

Pyridinone compounds for use in photodynamic therapy

A compound which is a compound of formula (i) or any salt thereof: wherein r1 is a ci-c6 alkyl group, r2 is h or a ci-c6 alkyl group, r3 is h or a ci-c6 alkyl group, and n is an integer from 0 to 5.. .
University Of Exeter

Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof

The present disclosure includes and provides compositions comprising photosensitizing agents and their use in photodynamic therapy for the treatment of dermatological conditions.. .
Dermira, Inc.

Conjugate of a photosensitiser and chitosan and uses thereof

The present invention relates to novel chitosan-based conjugates, e.g. Nanocarriers, comprising a derivative of the biocompatible polymer chitosan conjugated to a photosensitising agent, and uses thereof in photochemical internalisation (pci) and photodynamic therapy (pdt).
Pci Biotech As

Apparatuses for positioning within an internal channel

Methods and apparatuses for positioning medical devices onto (or close to) a desired portion of the interior wall of an internal channel, such as for scan imaging, for photodynamic therapy and/or for optical temperature measurement. In one embodiment, a catheter assembly has a distal portion that can be changed from a configuration suitable for traversing the internal channel to another configuration suitable for scan at least a spiral section of the interior wall of an internal channel, such as an artery.
Advanced Cardiovascular Systems, Inc.



Photodynamic Therapy topics:
  • Photodynamic Therapy
  • Sensitizer
  • Fluorescence
  • Cancer Cells
  • Cancer Cell
  • Antibodies
  • Antimicrobial
  • Therapeutics
  • Hypertensive
  • Hypertension
  • Desmoplastic
  • Immunotherapy
  • Radiation Therapy
  • Digital Processing
  • Optical Fiber


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    This listing is a sample listing of patent applications related to Photodynamic Therapy for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Photodynamic Therapy with additional patents listed. Browse our RSS directory or Search for other possible listings.


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