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Photodynamic Therapy

Photodynamic Therapy-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW 5-ala derivatives and use thereof
Universite De Geneve
May 17, 2018 - N°20180133320

The present invention is directed to new 5-ala derivatives, particles and formulation thereof, related methods of preparation and methods of use thereof. In particular, the invention relates to compounds of the invention, particles and formulation thereof useful in the treatment of a cancer and/or the diagnosis of a cancer cell such as in photodynamic therapy or photodynamic diagnosis.
Conjugated porphyrin carbon quantum dots for targeted photodynamic therapy
Hong Kong Baptist University
May 10, 2018 - N°20180125976

The present disclosure relates to porphyrin containing carbon quantum dots useful for bioimaging and/or phytodynamic therapy.
Light irradiation method, light irradiation device, light irradiation system, device system for photodynamic diagnosis or ...
Sony Corporation
April 05, 2018 - N°20180093104

The present invention provides a light irradiation method using a pulse laser, which can be applied to technology of pdd and/or pdt, and a system for treating a tumor, which has an enhanced tumoricidal effect. A light irradiation method of irradiating a cell into which a photosensitive compound capable of generating singlet oxygen has been incorporated with a pulse ...
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Method for the production of a formulation of a hypericin salt
Sanochemia Pharmazeutika Ag
March 01, 2018 - N°20180055935

Photodynamic therapy of tumors such as bladder tumors includes photosensitizing with a photosensitizer that is a complex or a compound of hypericin and a polymeric complexing agent. The photosensitizer is formed from an alkali salt of hypericin and the polymeric complexing agent. The alkali salt of hypericin is a sodium salt or a potassium salt. The complexing agent is a ...
Formulation for photodynamic therapy
Sanochemia Pharmazeutika Ag
March 01, 2018 - N°20180055934

Photodynamic therapy of tumors such as bladder tumors includes photosensitizing with a photosensitizer that is a complex or a compound of hypericin and a polymeric complexing agent. The photosensitizer is formed from an alkali salt of hypericin and the polymeric complexing agent. The alkali salt of hypericin is a sodium salt or a potassium salt. The complexing agent is a ...
Specifically meso-substituted porphyrins and chlorins for photodynamic therapy
Freie Universität Berlin
February 08, 2018 - N°20180036284

Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for pdt of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and pdt treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, opthamological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. ...
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Phenothiazine-pyridine compounds and uses thereof
The Chinese University Of Hong Kong
January 04, 2018 - N°20180002348

The present invention provides a novel phenothiazine-pyridine compound that is an effective photosensitizer useful for photodynamic therapy. Also provided is a method for inhibiting cell proliferation or for treating a disease involving inappropriate cell proliferation.
System for treatment by photodynamic therapy and method for preparation of such system
Universite De Lille 2 Droit Et Sante
December 07, 2017 - N°20170348542

System for treatment by photodynamic therapy comprising: —an illuminating device (10) including a light emitting surface for illuminating an internal surface to be treated with a light adapted to activate a photosensitizer compound, the light emitting surface emitting light with a distribution of light power comprising fractions of light power decreasing from a maximum at the light emitting surface, the ...
New scaffolds and multifunctional intermediates for imaging psma and cancer therapy
The Johns Hopkins University
November 23, 2017 - N°20170333576

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to psma are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express psma or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express psma or for photodynamic therapy.
Photodynamic therapy device
November 02, 2017 - N°20170312537

A light source (2) including a plurality of leds (4); a light detector (3) that detects intensity of light emitted by the plurality of leds (4) as light intensity distribution of light emitted by the light source (2); and a light intensity distribution control circuit (6) that controls current, by which each of the plurality of leds (4) is driven, such that the intensity of the light ...
Use of alpha-(8-quinolinyloxy) mono-substituted phthalocyanine zinc for treatment of psoriasis
October 19, 2017 - N°20170296662

The present invention relates to a use of alpha-(8-quinolinyloxy) mono-substituted phthalocyanine zinc for the treatment of psoriasis. The use is suitable for various type of psoriasis by utilizing photodynamic therapy. The photosensitizer is used to treat psoriasis by utilizing laser wave length of 670 nm, with high light sensitivity, fast photobleaching, short time needed in protection from light, and avoiding ...
Assembly for photodynamic therapy
October 05, 2017 - N°20170281965

An assembly for photomedicine therapy comprising: (a) at least partially transparent body having an internal cavity; the internal cavity provided with input and output pipes configured for circulating a cooling agent via said internal cavity; and (b) at least one electrically energizable light source disposed within said internal cavity such that radiation from said at least one light source propagates ...
Photodynamic therapy composition
Case Western Reserve Univerity
October 05, 2017 - N°20170281789

A phthalocyanine compound or targeted conjugate thereof having the formula (i).
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Conjugates of porphyrinoid photosensitizers and glycerol-based polymers for photodynamic therapy
Biolitec Unternehmensbeteiligungs Ii Ag
August 31, 2017 - N°20170247384

Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for pdt of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and pdt treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. ...
Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof
The University Of Chicago
August 17, 2017 - N°20170231903

Metal-organic frameworks (mofs) comprising photosensitizers are described. The mofs can also include moieties capable of absorbing x-rays and/or scintillation. Optionally, the photo sensitizer or a derivative thereof can form a bridging ligand of the mof. Further optionally, the mof can comprise inorganic nanoparticles in the cavities or channels of the mof or can be used in combination with an ...
Adjustable illuminators and methods for photodynamic therapy and diagnosis
Dusa Pharmaceuticals, Inc.
August 03, 2017 - N°20170216616

An illuminator for photodynamically diagnosing or treating a surface includes a plurality of panels. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of panels. The plurality of light sources are configured to irradiate the surface with substantially uniform intensity visible light. The illuminator also includes a heat source configured to emit heat ...
Induced photodynamic therapy using nanoparticle scintillators as transducers
University Of Georgia Research Foundation, Inc.
July 27, 2017 - N°20170209575

Photodynamic therapy systems comprising a nanoparticle that emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic radiation, a photosensitizer which absorbs electromagnetic radiation of said first wavelength and a biocompatible mesoporous material are disclosed herein. In some examples, the photodynamic therapy system comprises a core comprising the nanoparticle, a first shell comprising the biocompatible mesoporous material, and a ...
Combinations of a photosensitizer with a hydrogen sulfide donor, thioredoxin inhibitor or nitroxide for use ...
University Of Exeter
July 20, 2017 - N°20170202966

Compounds for use the invention relates to a combination comprising (i) a compound a comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or ...
Photodynamic therapy photosensitizers
The Royal Institution For The Advancement Of Learning/mcgill University
July 13, 2017 - N°20170197993

A compound of formula (i) useful as a photosensitizer in photodynamic therapy is provided. There is also provided a photosensitizing composition for use in photodynamic therapy comprising this compound. Finally, there are provided a method of killing cells under oxidative stress conditions and a method for the selective delivery of singlet oxygen (1o2) to cells having an increased reactive oxygen ...
Device and method for use of photodynamic therapy
June 22, 2017 - N°20170173351

An apparatus including a light source provides for intracranial treatment of a tissue region of a brain of a patient. The intracranial treatment apparatus comprises an outer shaft having a proximal end and a distal end for positioning within the tissue region of the brain. The outer shaft defines a lumen extending between the proximal end and the distal end ...
Polymers and oligomers with aggregation-induced emission characteristics for imaging and image-guided therapy
The Hong Kong University Of Science And Technology
June 15, 2017 - N°20170168041

A fluorophore or conjugated polymer with aggregation-induced emission characteristics useful for drug tracking and delivery, identification and labeling of biological subjects, such as cells or parts of a cell, as well as for imaging, and image-guided photodynamic therapy are described herein.
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