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Photodynamic Therapy

Photodynamic Therapy-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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System for treatment by photodynamic therapy and method for preparation of such system
Universite De Lille 2 Droit Et Sante
December 07, 2017 - N°20170348542

System for treatment by photodynamic therapy comprising: —an illuminating device (10) including a light emitting surface for illuminating an internal surface to be treated with a light adapted to activate a photosensitizer compound, the light emitting surface emitting light with a distribution of light power comprising fractions of light power decreasing from a maximum at the light emitting surface, the ...
New scaffolds and multifunctional intermediates for imaging psma and cancer therapy
The Johns Hopkins University
November 23, 2017 - N°20170333576

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to psma are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express psma or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express psma or for photodynamic therapy.
Photodynamic therapy device
The Johns Hopkins University
November 02, 2017 - N°20170312537

A light source (2) including a plurality of leds (4); a light detector (3) that detects intensity of light emitted by the plurality of leds (4) as light intensity distribution of light emitted by the light source (2); and a light intensity distribution control circuit (6) that controls current, by which each of the plurality of leds (4) is driven, such that the intensity of the light ...
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Assembly for photodynamic therapy
The Johns Hopkins University
October 05, 2017 - N°20170281965

An assembly for photomedicine therapy comprising: (a) at least partially transparent body having an internal cavity; the internal cavity provided with input and output pipes configured for circulating a cooling agent via said internal cavity; and (b) at least one electrically energizable light source disposed within said internal cavity such that radiation from said at least one light source propagates ...
Photodynamic therapy composition
Case Western Reserve Univerity
October 05, 2017 - N°20170281789

A phthalocyanine compound or targeted conjugate thereof having the formula (i).
Multimodal ultrasound and photoacoustic contrast agent based on polymeric microparticles
Fujifilm Sonosite B.v.
September 07, 2017 - N°20170252467

The invention provides a multimodal ultrasound and photoacoustic contrast agent based on polymeric microparticles having a gas core and carrying at least one photoacoustic agent in its shell that stabilizes the gas core, for use in ultrasound and photoacoustic imaging. Such multimodal ultrasound and photoacoustic contrast agent is also suitable as a carrier of drugs and for use in photodynamic ...
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Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof
The University Of Chicago
August 17, 2017 - N°20170231903

Metal-organic frameworks (mofs) comprising photosensitizers are described. The mofs can also include moieties capable of absorbing x-rays and/or scintillation. Optionally, the photo sensitizer or a derivative thereof can form a bridging ligand of the mof. Further optionally, the mof can comprise inorganic nanoparticles in the cavities or channels of the mof or can be used in combination with an ...
Adjustable illuminators and methods for photodynamic therapy and diagnosis
Dusa Pharmaceuticals, Inc.
August 03, 2017 - N°20170216616

An illuminator for photodynamically diagnosing or treating a surface includes a plurality of panels. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of panels. The plurality of light sources are configured to irradiate the surface with substantially uniform intensity visible light. The illuminator also includes a heat source configured to emit heat ...
Induced photodynamic therapy using nanoparticle scintillators as transducers
University Of Georgia Research Foundation, Inc.
July 27, 2017 - N°20170209575

Photodynamic therapy systems comprising a nanoparticle that emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic radiation, a photosensitizer which absorbs electromagnetic radiation of said first wavelength and a biocompatible mesoporous material are disclosed herein. In some examples, the photodynamic therapy system comprises a core comprising the nanoparticle, a first shell comprising the biocompatible mesoporous material, and a ...
Combinations of a photosensitizer with a hydrogen sulfide donor, thioredoxin inhibitor or nitroxide for use ...
University Of Exeter
July 20, 2017 - N°20170202966

Compounds for use the invention relates to a combination comprising (i) a compound a comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or ...
Photodynamic therapy photosensitizers
The Royal Institution For The Advancement Of Learning/mcgill University
July 13, 2017 - N°20170197993

A compound of formula (i) useful as a photosensitizer in photodynamic therapy is provided. There is also provided a photosensitizing composition for use in photodynamic therapy comprising this compound. Finally, there are provided a method of killing cells under oxidative stress conditions and a method for the selective delivery of singlet oxygen (1o2) to cells having an increased reactive oxygen ...
Device and method for use of photodynamic therapy
The Royal Institution For The Advancement Of Learning/mcgill University
June 22, 2017 - N°20170173351

An apparatus including a light source provides for intracranial treatment of a tissue region of a brain of a patient. The intracranial treatment apparatus comprises an outer shaft having a proximal end and a distal end for positioning within the tissue region of the brain. The outer shaft defines a lumen extending between the proximal end and the distal end ...
Polymers and oligomers with aggregation-induced emission characteristics for imaging and image-guided therapy
The Hong Kong University Of Science And Technology
June 15, 2017 - N°20170168041

A fluorophore or conjugated polymer with aggregation-induced emission characteristics useful for drug tracking and delivery, identification and labeling of biological subjects, such as cells or parts of a cell, as well as for imaging, and image-guided photodynamic therapy are described herein.
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Water soluble anionic bacteriochlorophyll derivatives and their uses
The Hong Kong University Of Science And Technology
May 25, 2017 - N°20170143988

The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological ph, preferably bchls having a group coo<−>, cos<−>, so3<−>, ...
Multi-modal bioprobe for bladder cancer imaging and photodynamic therapy
Hong Kong Baptist University
April 20, 2017 - N°20170107238

The present invention relates to a new generation of pdt agents based on porphyrin-lanthanide complexes with specific functional groups which can specifically localize on particular tumors, and their pdt processes can be monitored via nir emission from erbium. In particular, the present invention provides a multi-modal lanthanide-porphyrin pdt agent (er—r3) that are capable of killing the bladder tumor ...
Adjustable illuminator for photodynamic therapy and diagnosis
Dusa Pharmaceuticals, Inc.
April 20, 2017 - N°20170106205

An adjustable illuminator for photodynamically diagnosing or treating a surface includes a plurality of first panels and at least one second panel. The plurality of first panels have wider widths and the at least one second panel has a narrower width. The narrower width is less than the wider widths. The illuminator further includes a plurality of light sources, each ...
Diagnostic device, therapeutic device, and uses thereof
Cerca Solutions, Llc
April 13, 2017 - N°20170100073

Apparatus, method, computing devices, and computer programs related to photodiagnosis and photodynamic therapy, methods of use thereof, and a method for detecting abnormal tissue, are provided,
Novel polygonum cuspidatum extracts and their use as photodynamic inactivating agents
Photodynamic Inc.
April 06, 2017 - N°20170095521

The present invention describes extracts of polygonum cuspidatum and related compositions that are capable of photodynamic inactivation (pdi) of microorganisms such as bacteria, viruses, fungi, and protozoa, and capable of killing or inactivating cancer cells. The present invention further describes methods of using said polygonum cuspidatum extracts and photodynamic inactivation (pdi) as a therapy for the treatment of microbial infection ...
Focal photodynamic therapy methods
Steba Maor Sa
March 30, 2017 - N°20170087375

Improved methods of treating prostate cancer by vascular-targeted photodynamic therapy, and improved methods of planning treatment, are presented using a light density index to plan and guide effective treatment.
Photodynamic therapy, formulation usable for this purpose, and method for the production and use thereof
Sanochemia Pharmazeutika Ag
March 30, 2017 - N°20170087249

A treatment of cancer, such as, for example, bladder cancer, uses a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone.
Irradiation device
Photocure Asa
March 16, 2017 - N°20170072217

An irradiation device for insertion into an orifice of the body for providing photodynamic therapy or diagnosis comprises: a housing 1, 21, 31, 51, 61, 71 adapted to be fully inserted and secured in the orifice, the housing 1, 21, 31, 51, 61, 71 enclosing an led lamp system 5, 25, 35, 45, 54, 62, 72 and a power source 41, 68, 78, for powering the led lamp system 5, 25, 35, 45, 54, 62, 72, wherein the device is independently operational while located within the orifice.
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