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Pharmaceutically Acceptable Salt

Pharmaceutically Acceptable Salt-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Tricyclic benzoxaboroles as antibacterial agents
Daiichi Sankyo Company, Limited
June 22, 2017 - N°20170174709

The present invention provides a tricyclic compound represented by general formula (i), a pharmaceutical salt thereof, or a stereoisomer thereof exhibits excellent antibacterial activity against gram-negative bacteria resistant bacteria thereof, and also being excellent in terms of safety. Furthermore, the present invention provides production processes, pharmaceutical compositions comprising a tricyclic compound, a pharmaceutically acceptable salt thereof, or a stereoisomer thereof ...
NEW Spiro-oxazines, indolinones and preparation thereof
Council Of Scientific & Industrial Research
June 22, 2017 - N°20170174706

The present invention relates to novel spiro-oxazine analogues of formula-i and indolinone compounds of formula-ii or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-i formula-ii further the invention provides transition-metal free multicomponent reaction (mcr) process for the preparation of said compounds of formula-i and ii using aryne precursor, n-substituted isatin and n-heteroaromatic compound as the nucleophile, ...
NEW Soluble guanylate cyclase stimulators
Council Of Scientific & Industrial Research
June 22, 2017 - N°20170174693

Or a pharmaceutically acceptable salts thereof, wherein x, y, z, r1, r2, r4, ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cgmp”), and are generally suitable for the therapy and prophylaxis of diseases which are associated ...
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NEW Substituted indoles
Syros Pharmaceuticals, Inc.
June 22, 2017 - N°20170174688

Wherein r1, r2, r3, r4, r5, and r6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by suv420h1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (i).
NEW Pyridazine compounds as jak inhibitors
Portola Pharmaceuticals, Inc.
June 22, 2017 - N°20170174673

In one aspect, the invention provides a compound according to formula i, as well as tautomers, pharmaceutically acceptable salts, and hydrates thereof. Pharmaceutical compositions, methods of inhibiting janus kinases (jaks), and methods for treating a condition or disorder mediated at least in part by jak kinase activity are also described.
NEW Pyrazolone compounds and uses thereof
Inception 2, Inc.
June 22, 2017 - N°20170174666

The invention disclosed herein is directed to compounds of formula i [formula should be entered here] and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, acute or chronic myeloid leukemia, melanoma, and other cancers. The invention also includes pharmaceutical compositions comprising a therapeutically effective amount of compound of formula ...
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NEW 2-phenylbenzofuran derivatives, method for preparing the same and use of the same for treating inflammatory ...
Dongguk University Industry-academic Cooperation Foundation
June 22, 2017 - N°20170174645

The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing ...
NEW Primary carboxamides as btk inhibitors
Dongguk University Industry-academic Cooperation Foundation
June 22, 2017 - N°20170174624

Pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
NEW Fenfluramine compositions and methods of preparing the same
Zogenix International Limited
June 22, 2017 - N°20170174613

Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; ...
NEW Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
Cydex Pharmaceuticals, Inc.
June 22, 2017 - N°20170173178

The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (sae-cd). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The sae-cd serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of ...
NEW Composition for preventing or treating muscle wasting-related disease and use thereof
Samsung Electronics Co., Ltd.
June 22, 2017 - N°20170173064

Provided is a pharmaceutical composition for preventing or treating a muscle wasting-related disease of a subject, the composition including one or more compounds selected from the group consisting of isotretinoin, vismodegib, and lincomycin, pharmaceutically acceptable salts, stereoisomers, derivatives, or solvates thereof, or combinations thereof, and a method of preventing or treating a muscle wasting-related disease using the same.
NEW Methods of treating ovarian cancer
Cipla Limited
June 22, 2017 - N°20170173052

Disclosed herein are methods of treating ovarian cancer comprising administering to a subject in need thereof an effective amount of methacycline, or a pharmaceutically acceptable salt thereof. The methacycline can be administered as part of treatment regimen, which also can include other chemo- or immune-therapies, radiation therapy, and/or surgical treatments.
NEW Withacnistin compounds for treatment of cancer
University Of South Florida
June 22, 2017 - N°20170173049

The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of stat3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing one or more withacnistin compounds, or a pharmaceutically acceptable salt or derivative thereof. In one embodiment, the subject invention concerns a composition comprising a mixture of ...
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NEW Pharmaceutical formulations of a pan-raf kinase inhibitor, processes for their preparation, and methods of use
Millennium Pharmaceuticals,inc.
June 22, 2017 - N°20170173033

The invention relates to a pharmaceutical composition comprising compound 1 or a pharmaceutically acceptable salt thereof for the treatment of cancer and a process for its preparation. The invention also relates to administering the pharmaceutical composition to a patient according to an intermittent dosing regimen.
NEW Combination of a pi3 kinase inhibitor with pacitaxel for use in the treatment or prevention ...
Novartis Ag
June 22, 2017 - N°20170173032

A pharmaceutical combination comprising (a) a phosphatidylinositol-3-kinase (pi3k) inhibitor compound of formula (i), as defined herein, or a pharmaceutically acceptable salt thereof and (b) paclitaxel or a pharmaceutically acceptable salt thereof for simultaneous, separate or sequential use, for the treatment of a cancer of the head and neck; a pharmaceutical composition comprising said combination; the use of said ...
NEW 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4h-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
Novartis Ag
June 22, 2017 - N°20170173025

And pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme mpo and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions.
NEW Combination therapy for cancer
Eli Lilly And Company
June 22, 2017 - N°20170173013

The present invention provides preparation of medicaments for use in treating and methods of treating non-small cell lung cancer in a patient comprising: [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3h-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine, or a pharmaceutically acceptable salt thereof, in combination, as further described herein, with an anti-vegfr2 antibody, preferably, ramucirumab.
NEW Pyridazinone compounds and their use as daao inhibitors
Takeda Pharmacuetical Company Ltd.
June 22, 2017 - N°20170173007

The present invention provides compounds of formula (i) and pharmaceutically acceptable salts thereof, wherein r1 and r2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
NEW Particulate materials
Nektar Therapeutics
June 22, 2017 - N°20170173006

Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing such particles or formulations. In one embodiment, a composition of an aerosol formulation is provided and contains a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 μ...
NEW Methods for treating inflammatory conditions
Melior Discovery, Inc.
June 22, 2017 - N°20170173004

The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising tenilsetam or pharmaceutically acceptable salts thereof that are useful in modulating inflammation. In particular, the compounds or pharmaceutically acceptable salts thereof are useful for treating or preventing a disease or disorder involving inflammation, including, but not limited to, delayed type hypersensitivity and contact hypersensitivity.
NEW Treatment of androgen deprivation therapy associated symptoms
Eli Lilly And Company
June 22, 2017 - N°20170172992

The present invention provides a method of treating symptoms associated with androgen deprivation therapy comprising administering to a patient in need of such treatment an effective amount of a compound of formula i: [formula should be inserted here] or a pharmaceutically acceptable salt thereof.
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