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|| List of recent Phage-related patents
| Devices, systems, and methods for controlling temperature in pediatric subjects|
Methods, devices, and systems for temperature management of a pediatric patient in a perioperative environment are disclosed. Methods, devices, and systems for maintaining normothermia in a pediatric patient in a perioperative environment are disclosed.
| Injectable microspheres for dermal augmentation and tissue bulking|
The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation.
| Antibody with specificity for gm-csf (ii)|
The present invention relates to antibodies with specificity for granulocyte-macrophage colony stimulating factor (gm-csf). More particularly, the invention relates to humanized monoclonal antibodies that bind specifically to human gm-csf with high affinity.
| Agents and method for treating inflammation-related conditions and diseases|
Gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages. Gene-modified, inflammation-specific macrophages that comprise a 1-alpha-hydroxylase gene.
| Staphylococcus haemolyticus prophage phish2 endolysin is lytic for staphylococcus aureus|
Methicillin-resistant (mrsa) and multi-drug resistant strains of staphylococcus aureus are becoming increasingly prevalent in both human and veterinary clinics. S.
| Prevention and remediation of petroleum reservoir souring and corrosion by treatment with virulent bacteriophage|
There is provided a safe, natural, environmentally sound means of controlling bacterial contamination, corrosion, and souring of oil and gas wells and reservoirs that result from bacteria-contaminated water in a well. In one aspect it is a process for remediation of souring of petroleum reservoirs and coalbeds by adding to the water used in flooding and “fracing” operations an effective amount of virulent (non-lysogenic) bacteriophages (phages) specific for problematic target bacteria.
|Cell model and method for screening c-fms kinase inhibitors|
The present invention provides a cell model and a method for screening c-fms tyrosine kinase inhibitors. Specifically, the present invention provides a cell that expresses macrophage colony stimulating factor receptor and stat1 protein simultaneously.
|Methods and vectors for generating asialylated immunoglobulins|
The properties of an fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the fc region by transfecting the cell line expressing the fc-containing protein with a vector sequence encoding a sialidase. The modified fc-containing proteins have therapeutic utility in diseases or conditions in which it is desirable to control the affinity for one or more of the fcγri, fcγriia, and fcγriiia receptors, adcc activity, macrophage or monocyte activation, serum half-life, and avidity..
|Treatment and diagnosis of macrophage mediated disease|
Where the group ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group x comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, x comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis..
|Self-adjusting gastric band|
A self-adjusting gastric band comprises an inflatable portion that includes a fluid such as saline. A reservoir is spaced from the inflatable portion according to a distance related to a wavelength of a peristaltic wave that propagates through the esophageal-gastric junction.
|Recombinant super-compound interferon and uses thereof|
This invention provides a method for treating tumors in a subject, comprising administering to the subject an effective amount of a recombinant interferon, wherein the interferon has the amino acid sequence of seq id no:2 and is encoded by the nucleotide sequence seq id no:1, wherein the tumors are selected from the group consisting of skin cancer, basal cell carcinoma, liver cancer, thyroid cancer, rhinopharyngeal cancer, solid carcinoma, prostate cancer, esophageal cancer, pancreatic cancer, superficial bladder cancer, hemangioma, epidermoid carcinoma, cervical cancer, glioma, leucocythemia, acute leucocythemia, chronic leucocythemia, lymphadenoma, and polycythemia vera.. .
|Treatment of immune-related and inflammatory diseases|
Provided herein are methods of using compounds and compositions for modulating leukocytic activity, including activity of b cells and/or t cells monocytes, macrophages, and other lymphoid or myeloid-derived cell types, in immune-related diseases or inflammatory diseases. Pharmaceutical compositions and dosing regimens for use in the methods are also provided herein..
|Tivozanib response prediction|
A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (av-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor.
|Agent for preventing bacterial wilt disease, and method for preventing bacterial wilt disease|
Provided are: an agent for preventing bacterial wilt disease, which agent can prevent the development of bacterial wilt disease caused by various different bacterial wilt disease strains, that is, the development of bacterial wilt disease in various different plant varieties; and a method for preventing bacterial wilt disease utilizing the agent for preventing bacterial wilt disease. The agent for preventing bacterial wilt disease comprises as an active ingredient a wilt bacterium (ralstonia solanacearum) infected with the φrsm1-type filamentous phage and/or the φrsm3-type filamentous phage.
|Microvesicles derived from nucleated, mammalian cells and use thereof|
The present invention relates to a microvesicle that is derived from nucleated mammalian cells, which are smaller than the nucleated cells. The microvesicles of the present invention can be used in the delivery of a therapeutic or diagnostic substance to specific tissues or cells, and more particularly, relates to microvesicles derived from monocytes, macrophages, dendritic cells, stem cells or the like, which can be used to deliver specific therapeutic or diagnostic substances for treating and/or diagnosing tissue associated with cancer, diseased blood vessels, inflammation, or the like..
|Implantable device for directional control of flow within the anatomic tracts of the body|
The systems and methods described herein related generally to a device that enables the directional control of flow through an anatomical tract of the body. More particularly, the device described herein includes a valve from a plurality of projections.
|Method of treating of gastroesophageal reflux disease|
The development of agents for gastroesophageal reflux disease, in which existing treatment is not effective, is strongly demanded. An object of the present invention is to provide an agent for preventing or relapse-preventing, treating or ameliorating such gastroesophageal reflux disease.
|Compositions for the symptomatic relief of stomach pain or gastrooesophageal reflux|
Compositions useful for relieving the symptoms commonly known as stomach acidity, heartburn or, more technically, esophageal reflux (gerd), that comprise a fatty acid and a plant extract. These compositions have been tried in patients with clinical records of previous diagnosis of gerd, chronic heartburn, or esophagitis, with a high degree of success..
|Composition comprising expression or activity inhibitors of ninjurin1 for the prevention and treatment of inflammatory disease|
The present invention relates to a composition comprising a ninjurin1 expression or activity inhibitor for the prevention and treatment of inflammatory disease. Ninjurin1 protein is specifically expressed in macrophages around blood vessels, increases cell-cell adhesion and cell-matrix adhesion, increases expressions of wnt7b (wingless-type mmtv integration site family, member 7b) and ang2 (angiopoietin-2), but reduces expression of ang1 to induce apoptosis of vascular endothelial cells.
|Cell-based, anti-cancer vaccines|
The present invention relates to cancer vaccines and more particularly to compositions and methods for producing activated antigen presenting cells (dendritic cells, macrophages, monocytes, or other cells capable of presenting antigen to t lymphocytes); to pharmaceutical compositions including such cells; and to methods of using such cells (e.g., in treating patients who are suffering from or at risk of developing cancer).. .
|Beneficial effects of bacteriophage treatments|
The invention relates to use of one or more bacteriophages in vivo in a human or animal in order to induce sensitivity to chemical antibiotics in bacterial cells, where such susceptibility is heritable, independent of continuing bacteriophage metabolism within those cells, and does not relate to the destruction of a biofilm to induce such sensitivity.. .
|Il-25 treatment of obesity and metabolic disorders|
The present invention provides a method for reducing the weight of a subject, preventing weight gain in a subject, lowering blood glucose, or treating hepatic steatosis, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising interleukin-25 or il-25-activated macrophages. In addition, the present invention provides a method of treating cachexia or promoting weight gain in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising an inhibitor or antagonist of interleukin-25 in a mammal in the treatment of cachexia..
|Implantable devices for controlling the internal circumference of an anatomic orifice or lumen|
An implantable device for controlling the circumference of internal anatomic passages corrects physiologic dysfunctions resulting from a structural lumen which is either too large or too small. Implants area disclosed which employ various means for adjusting and maintaining the size of an orifice to which they are attached.
|Non-invasive device for diagnosing gastroesphageal reflux|
The present invention provides compositions and methods useful in the diagnosis and management of gastroesophageal reflux. Specifically, the inventions provide a device and methods of using the device for accurately, quantitatively, and non-invasively diagnosing gastroesophageal reflux disease (gerd) in both patients at risk for gerd and patients demonstrating reflux-like symptoms.
|Serum-based mirna microarray and its use in diagnosis and treatment of barrett's esophagus (be) and esophageal adenocarcinoma (eac)|
Robust and reliable molecular diagnostic screening tools for early detection of esophageal and gastrointestinal tract cancers and pre-cancerous lesions, such as barrett's esophagus, and esophageal adenocarcinoma are provided. Included in the invention is an array of mirna probes specific for identifying, diagnosing and prognosticating esophageal and gastrointestinal tract cancers and pre-cancerous lesions in subjects from blood or serum samples.
|Electrically conductive polymer electrodes with incorporated viruses|
Grafting m13 bacteriophage into an array of poly(3,4-ethylenedioxythiophene) (pedot) nanowires generated hybrids of conducting polymers and replicable genetic packages (rgps) such as viruses. The incorporation of rgps into the polymeric backbone of pedot occurs during electropolymerization via lithographically patterned nanowire electrodeposition (lpne).
|Sortase-mediated modification of viral surface proteins|
The present invention, in some aspects, provides methods, reagents, and kits for the functionalization of proteins on the surface of viral particles, for example, of bacteriophages, using sortase-mediated transpeptidation reactions. Some aspects of this invention provide methods for the conjugation of an agent, for example, a detectable label, a binding agent, a click-chemistry handle, or a small molecule to a surface protein of a viral particle.
|Bacteriophage treated food products|
Food treated with bacteriophage, as to reduce or prevent the growth of undesirable bacteria. The food may be coated with bacteriophage and rubbed to distribute the phage on the food surface.
|Methods and compositions for remediating microbial induced corrosion and environmental damage, and for improving wastewater treatment processes|
A method for remediating bacterially-induced corrosion, environmental damage, and/or process inefficiencies in an industrial process includes identifying an industrial process where target bacteria adversely affect corrosion, environmental impact, and/or process efficiencies. The process also includes identifying the strains of the target bacteria, obtaining a bacteriophage virulent against one or more of the strains of the target bacteria, and exposing the target bacteria to the bacteriophage.
|Macrophage activating factor for pharmaceutical compositions|
Pharmaceutical compositions including macrophage activating factor (maf) and method of producing same, particularly to maf compositions essentially devoid of glycosidase enzymes. The compositions of the present invention and pharmaceutical compositions including same are particularly suitable for intravenous administration..
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Phage topics: Esophageal, Macrophage, Antagonist, Nucleic Acid, Antibodies, Physiologic, Oligodendrocyte, Nucleic Acids, Therapeutics, Myelination, Endogenous, Dysfunction, Differentiation, Monoclonal, Thromboxane
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