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Peptide patents



      
           
This page is updated frequently with new Peptide-related patent applications. Subscribe to the Peptide RSS feed to automatically get the update: related Peptide RSS feeds. RSS updates for this page: Peptide RSS RSS


Compositions and methods for substrate-selective inhibition of endocannabinoid oxygenation

Compositions and methods for substrate-selective inhibition of endocannabinoid oxygenation

Date/App# patent app List of recent Peptide-related patents
07/02/15
20150186595
 Bioinformatics platform for high-throughput identification and quantification of n--glycopeptide patent thumbnailnew patent Bioinformatics platform for high-throughput identification and quantification of n--glycopeptide
The present invention relates to a more efficient and accurate method for the identification and quantification of comparatively low abundant glycopeptides, compared with general peptides, using mass spectrum obtained by using high resolution mass spectrometer. Therefore, the method of the present invention can be effectively used for the techniques for identification of biotherapeutics and diagnosis of cancer or disease by screening glycopeptide, the disease marker (biomarker), from various samples..
07/02/15
20150185231
 Method and kit for detecting the early onset of renal tubular cell injury patent thumbnailnew patent Method and kit for detecting the early onset of renal tubular cell injury
A method and kit for detecting the early onset of renal tubular cell injury, utilizing ngal as an early urinary biomarker. Ngal is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury.
07/02/15
20150185223
 Compositions comprising rac mutants, and methods of use thereof patent thumbnailnew patent Compositions comprising rac mutants, and methods of use thereof
The present invention is based, in part, on the discovery of isolated nucleic acid molecules encoding mutant rac polypeptides, or fragments thereof, wherein the mutant rac polypeptides comprise one or more substitutions of an amino acid in the wild-type rac polypeptide that renders the mutant rac polypeptides constitutively active and oncogenic. Isolated mutant rac polypeptides encoded by such nucleic acid molecules, as well as vectors, host cells, methods of producing encoded polypeptides using such isolated nucleic acid molecules, as well as methods of using mutant rac nucleic acids and polypeptides for identifying, assessing, prognosing, and treating cancer, are also provided..
07/02/15
20150185222
 Method for detecting cancer patent thumbnailnew patent Method for detecting cancer
This invention provides: a method for detecting a cancer, comprising measuring the expression of a polypeptide having binding reactivity through antigen-antibody reaction with an antibody against caprin-1 having the amino acid sequence shown in any even-numbered seq id no of seq id nos: 2 to 30 in the sequence listing in a biological sample; a method for detecting a cancer which involves determining the presence and the amount of caprin-1 in a sample of a cancer patient in order to determine the administration of a caprin-1-targeting drug to the cancer patient; and a drug and a kit for the diagnosis of a cancer, comprising an anti-caprin-1 antibody.. .
07/02/15
20150185216
 Systemic discovery, maturation and extension of peptide binders to proteins patent thumbnailnew patent Systemic discovery, maturation and extension of peptide binders to proteins
The invention comprises systems, methods and arrays for identification and optimization of novel peptide binders to protein targets. Embodiments include steps of peptide binder discovery, core peptide maturation, n-terminal and c-terminal extension and kinetics analysis of the final peptide binder..
07/02/15
20150185205
 Fluorescent fusion polypeptide, biosensor comprising said polypeptide and uses thereof patent thumbnailnew patent Fluorescent fusion polypeptide, biosensor comprising said polypeptide and uses thereof
The present invention refers to a fluorescent fusion polypeptide capable of changing its localization within the cell from the cell cytoplasmic membrane to the retention vesicles, upon an increase in the concentration of second messengers within the cell cytoplasm, comprising a membrane localization peptide, a second messenger transduction protein binding peptide, a reticulum retention signal and a fluorescent peptide wherein: a. The membrane localization peptide is located at the n-terminus of the fluorescent fusion polypeptide and is physically bound, optionally through a linker, to the fluorescent peptide, which in turn is physically bound, optionally through a linker, to the second messenger transduction protein binding peptide; and b.
07/02/15
20150184249
 Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) patent thumbnailnew patent Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
Described herein are mutations that confer resistance to treatment with a btk inhibitor. Described herein are modified btk polypeptides that exhibit decreased inhibition (i.e.
07/02/15
20150184220
 Methods, peptides, and biosensors useful for detecting a broad spectrum of bacteria patent thumbnailnew patent Methods, peptides, and biosensors useful for detecting a broad spectrum of bacteria
Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (rsl) domain of the α1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates.
07/02/15
20150184215
 Development of the soluble recombinant crm197 production by e. coli patent thumbnailnew patent Development of the soluble recombinant crm197 production by e. coli
A method for recombinant production of a crm197 protein includes culturing a recombinant escherichia coli cell to produce said crm197 protein, and isolating said crm197 protein. The recombinant escherichia coli cell includes an expression vector, which contains a nucleic acid molecule that encodes a fusion protein that includes an e.
07/02/15
20150184211
 Novel lignases and aldo-keto reductases for conversion of lignin-containing materials to fermentable products patent thumbnailnew patent Novel lignases and aldo-keto reductases for conversion of lignin-containing materials to fermentable products
Termites have specialized digestive systems that overcome the lignin barrier in wood to release fermentable simple sugars. Using the termite reticulitermes flavipes and its gut symbionts, high-throughput titanium pyrosequencing and proteomics approaches experimentally compared the effects of lignin-containing diets on host-symbiont digestome composition.
07/02/15
20150184191
new patent

Yield and stress tolerance in transgenic plants iv


Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered c/n sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant..
07/02/15
20150184188
new patent

Plants with enhanced size and growth rate


Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention regulate transcription in these plants and have been shown to confer at least one regulatory activity that results in increased size, biomass, growth rate, and/or yield as compared to a control plant..
07/02/15
20150184173
new patent

Compositions and methods comprising sequences having meganuclease activity


Compositions and methods comprising polynucleotides and polypeptides having meganuclease activity are provided. Further provided are nucleic acid constructs, yeast, plants, plant cells, explants, seeds and grain having the meganuclease sequences.
07/02/15
20150184169
new patent

Sulfonylurea-responsive repressor proteins


Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound.
07/02/15
20150184161
new patent

Eml4-alk fusion gene


The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene.
07/02/15
20150184158
new patent

Translocation and mutant ros kinase in human non-small cell lung carcinoma


In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of sodium-dependent phosphate transporter isoform napi-3b protein (slc34a2) with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The slc34a2-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
07/02/15
20150184143
new patent

Cyaa-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses


The invention relates to a chimeric protein comprising or consisting of from n-terminal to c-terminal, (a) a n-terminal part of a bordetella cyaa protein (b) a heterologous polypeptide, and (c) a c-terminal part of a bordetella cyaa protein. The invention also relates to a polynucleotide encoding a deleted version of a bordetella cyaa, as well as a polynucleotide encoding this chimeric protein.
07/02/15
20150184142
new patent

Procoagulant compounds


The present disclosure provides protease-activatable procoagulant compounds comprising a procoagulant polypeptide, e.g., a procoagulant peptide and/or clotting factor, and a linker comprising a protease-cleavable substrate (e.g., a synthetic thrombin substrate) and a self-immolative spacer (e.g., p-amino benzyl carbamate). Upon cleavage of the protease-cleavable substrate by a protease (e.g., thrombin), the self-immolative spacer cleaves itself from the procoagulant polypeptide such that the polypeptide is in an underivatized and active form.
07/02/15
20150184128
new patent

Truncated epiderimal growth factor receptor (egfrt) for transduced t cell selection


A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human epidermal growth factor receptor polypeptide (egfrt) that lacks the membrane distal egf-binding domain and the cytoplasmic signaling tail, but retains an extracellular epitope recognized by an anti-egfr antibody is provided.
07/02/15
20150183884
new patent

Alpha-enolase specific antibodies and methods of uses in cancer therapy


The present invention discloses an anti-human alpha-enolase (eno1) antibody, which can bind the peptides, comprising amino-acid sequence 296fd q d d w g a w q k f ta309 (seq id: #9) and/or 326k r i a k a v n ek s336 (seq id: #10) of human eno1 protein (genbank: aah50642.1), has a favorable binding activity (the binding affinity is around 2.19×10-10 mol/l) and a remarkable capability to inhibit the cell invasion and tumor metastasis of a varied of tumors. The recognized peptides and antibody of the invention are useful for diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface eno1 such as including lung, breast, pancreas, liver, colorectal, prostate cancers and solid tumors..
07/02/15
20150183873
new patent

Engineered immunoglobulin fc polypeptides


Methods and compositions involving polypeptides having an aglycosylated antibody fc domain. In certain embodiments, polypeptides have an aglycosylated fc domain that contains one or more substitutions compared to a native fc domain.
07/02/15
20150183869
new patent

Variable region sequences of il-31 monoclonal antibodies and methods of use


Novel compositions derived from antigen-binding sites of immunoglobulins having affinity for il-31 are provided. The compositions exhibit immunological binding properties of antibody molecules capable of binding specifically to a human il-31.
07/02/15
20150183864
new patent

Fusion protein capable of binding vegf-a and tnf-alpha


The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding vegf polypeptide and tnf polypeptide comprising: (a) a nucleotide sequence encoding a tnfr2 component and vegfr1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the tnfr2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of tnfr2, and wherein the vegfr1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of ig-like domain 2 of the extracellular domain of vegfr1.. .
07/02/15
20150183858
new patent

Peptide-hinge-free flexible antibody-like molecule


The present invention provides an antibody that can bind to targets with greater affinity. A flexible antibody-like molecule having a nonpeptide hinge part comprising: a group having a nonpeptide hinge part represented by a general formula (i): xy-asp-lys-thr-his-thr (seq id no.
07/02/15
20150183857
new patent

Methods and compositions comprising supramolecular constructs


The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, p170 glycoprotein.
07/02/15
20150183854
new patent

Therapeutic agent or prophylactic agent for dementia


The invention provides an antibody that participates in antigen-antibody reaction specifically with tau protein that has been phosphorylated in the vicinity of ser413 of seq id no: 1, and a therapeutic agent or prophylactic agent for cognitive disorders comprising as an active ingredient a peptide that has been phosphorylated in the vicinity of ser413.. .
07/02/15
20150183848
new patent

Treatment of lge-mediated disease


The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble cd23 (scd23) that binds and sequesters ige. Thus, the scd23 peptides, polypeptides and derivatives described herein are useful for treating conditions or disorders involving increased ige levels such as e.g., allergy, anaphylaxis, inflammation, lymphoma, and certain cancers..
07/02/15
20150183847
new patent

Protein and protein conjugate for diabetes treatment, and applications thereof


The present invention relates to the field of biopharmaceutics, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use for treating diabetes. The fusion protein of the present invention is obtained by linking two polypeptides, wherein one polypeptide is an interleukin-1 receptor antagonistic protein or an analogue thereof, and another polypeptide is glp-1 receptor binding polypeptide or an analogue thereof, or an insulin receptor binding polypeptide or an analogue thereof, or a gip receptor binding polypeptide or an analogue thereof.
07/02/15
20150183844
new patent

Chimeric neuregulins and making and use thereof


Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, erb 3, or erb 4 comparing to that of the first neuregulin..
07/02/15
20150183839
new patent

Soybean nodulation regulatory peptides and methods of use


peptide fragments of clavata3/esr-related (cle) proteins of soybean are provided which are activators of autoregulation of nodulation in soybean. Cle30 and cle80 peptide fragments may act systemically while cle60 peptides may act locally in the plant root.
07/02/15
20150183838
new patent

Biomass productivity regulator


The disclosure generally relates to methods and materials for modulating cell productivity. In particular, the present disclosure provides polynucleotides and polypeptides that when overexpressed in microorganisms result in increased in productivity, such as increased biomass productivity.
07/02/15
20150183837
new patent

Immunogenic compositions and methods of use thereof


Embodiments of the disclosure encompass compositions and methods for generating immune responses in an animal or human host. Embodiments of the compositions encompass proteins derived from the surface proteins of bacteria and protozoa, and in particular the flagellum component flagellin, and which have adjunctival properties when administered in conjunction with an immunogen.
07/02/15
20150183835
new patent

Stabilized gp120


The present invention provides an isolated polypeptide comprising an hiv gp120 polypeptide or soluble gp140 polypeptide stabilized in a conformation which exposes both cd4-bound and cd4-binding site epitopes. The invention also provides immunogenic compositions and methods of treating and preventing infection with hiv..
07/02/15
20150183834
new patent

Filoviral immunosuppressive peptides


The invention provides a region of strong secondary structure conservation between the c-terminus domain of the envelope glycoprotein of filoviruses and an immunosuppressive domain found in retroviral envelope glycoproteins. The invention provides filoviral peptides and modified derivatives thereof with strong immunosuppressive bioactivity.
07/02/15
20150183832
new patent

Use of pedf-derived polypeptides for promoting stem cells proliferation and wound healing


Disclosed herein is a synthetic peptide, which has an amino acid sequence that has 20-39 amino acid residues. The synthetic peptide has at least 80% amino acid sequence identity to seq id no: 1, and includes at least 20 consecutive residues that has at least 90% amino acid sequence identity to residues 11-30 of seq id no: 1.
07/02/15
20150183831
new patent

Method for producing cereulide and derivative thereof, intermediate for production of cereulide, and cereulide derivative


The purpose of the present invention is to provide a novel method for producing cereulide and a derivative thereof; an intermediate for cereulide; and a novel cereulide derivative. A novel didepsipeptide, a novel tetradepsipeptide, a novel octadepsipeptide and a novel dodecadepsipeptide are prepared.
07/02/15
20150183830
new patent

Methods for preparing purified lipopeptides


The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics.
07/02/15
20150183829
new patent

Rfamide-related peptides and methods thereof


Provided herein methods and compositions directed to rfrp-1 polypeptides for modulating cardiac contractile function, for preventing and/or treating cardiac disorders.. .
07/02/15
20150183828
new patent

Self-assembling peptides incorporating modifications and methods of use thereof


The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule.
07/02/15
20150183827
new patent

Cell penetrating peptides & methods of identifying cell penetrating peptides


The present invention relates to cell penetrating peptides and methods of identifying cell penetrating peptides based upon hydrophobicity and polarity.. .
07/02/15
20150183826
new patent

Cd44v6-derived peptides for treating metastasizing cancer


The present invention relates to compounds, pharmaceutical compositions and methods for treating different forms of pancreatic cancer.. .
07/02/15
20150183824
new patent

Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including beta-amino acids prepared via mukaiyama aldol addition


The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine.
07/02/15
20150183823
new patent

Cosmetic or pharmaceutical compositions including tripeptides capable of stimulating cyclic adenosine monophosphate synthesis and their use in the treatment and/or care of the skin and/or hair


Its stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, in the treatment and/or care of conditions, disorders and/or diseases of the skin and/or hair by stimulating cyclic adenosine monophosphate synthesis (camp).. .
07/02/15
20150183822
new patent

Angiotensin-converting-enzyme inhibiting dipeptide


[problem] to provide a useful dipeptide-containing composition derived from dried bonito flakes and the like, having an angiotensin-converting-enzyme inhibiting activity that imparts a blood pressure reducing function. [solution] a composition containing a dipeptide derived from a fish meat protein having an angiotensin-converting-enzyme inhibiting activity.
07/02/15
20150183737
new patent

Compositions and methods for substrate-selective inhibition of endocannabinoid oxygenation


Methods for selectively inhibiting endocannabinoid oxygenation but not arachidonic acid oxygenation. In some embodiments, the methods include contacting a cox-2 polypeptide with an effective amount of a substrate-selective cox-2 inhibitor.


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This listing is a sample listing of patent applications related to Peptide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Peptide with additional patents listed. Browse our RSS directory or Search for other possible listings.
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