|| List of recent Peptide-related patents
| Nuclease fusion protein and uses thereof|
The present invention is concerned with nuclease fusion proteins and various uses thereof. Specifically, it relates to a polynucleotide encoding a polypeptide comprising (i) a first module comprising at least a first dna binding domain derived from a homing endonuclease, (ii) a linker, and (iii) a second module comprising at least a second dna binding domain and a cleavage domain derived from a restriction endonuclease, wherein said polypeptide functionally interacts only with dna comprising a dna recognition site for the first dna binding domain and a dna recognition site for the second dna binding domain, and wherein said cleavage domain cleaves dna within a specific dna cleavage site upon binding of the polypeptide.
| Novelcrosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof|
The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable.
| Peptides modified with triterpenoids and small organic molecules: synthesis and use in cosmeceutical|
The present invention relates to the synthesis of triterpenoid peptides and mechanism of action for anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix.
| Peptide synthesis apparatus and methods using infrared energy|
Apparatus and methods utilizing infrared energy for heating reactions associated with peptide synthesis, such as activation, deprotection, coupling, and cleavage. Thorough agitation of the contents of reaction vessels during heating and real-time monitoring and adjustment of temperature and/or reaction duration are also described.
| Compositions and methods for recognition of rna using triple helical peptide nucleic acids|
Peptide nucleic acids containing thymidine and 2-aminopyridine (m) nucleobases formed stable and sequence selective triple helices with double stranded rna at physiologically relevant conditions. The m-modified pna displayed unique rna selectivity by having two orders of magnitude higher affinity for the double stranded rnas than for the same dna sequences.
| Targeting vector-phospholipid conjugates|
Peptide vectors having high kdr binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions.
| Mrm/srm assay for death receptor 5 protein|
Specific peptides, and derived ionization characteristics of those peptides from death receptor 5 (dr5) protein are provided that are particularly advantageous for quantifying the dr5 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
| Srm/mrm assay for the fatty acid synthase protein|
Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
| Expression of il-12 family heterodimers|
The present invention provides methods of improving the levels and stability of expression of interleukin-12 family cytokine polypeptides by expressing the alpha and beta subunits of the polypeptides at their determined relative molar ratios that increase the levels and stability of expression of the heterodimer, e.g., in comparison to heterodimer expressed at an equimolar ratio.. .
| Methods and compositions for inhibiting cellular proliferation and surgical adhesion|
The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The present invention relates to the discovery that a synthetic anionic polymer consisting of dextran-sulfate (anionic carbohydrate) conjugated to tirofiban (an anti-platelet agent which prevents platelet activation and aggregation) can effectively inhibit adhesions that form during surgery.
| Polypeptides for treating and/or limiting influenza infection|
Polypeptides are disclosed herein, which recognize and are strong binders to influenza a hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection.. .
| Kisspeptide-pentasaccharide conjugates|
The invention relates to kisspeptide-pentasaccharide conjugates having the general formula (i) wherein z1 is tyr or d-tyr; z3 is trp, hyp, phe or lys(r2); z5 is thr, aib or ala; z7 is gly or azagly; z8 is leu; or z7 and z8 together represent; z10 is phe or trp; n is 0 or 1; or r2, when present, represents a pentasaccharide derivative having the formula (ii) wherein r is methyl or so3x; x is a positively charged counterion; with the proviso that when r2 is present, r1 is h or (c1-6) alkylcarbonyl; r3 is h or (c1-3)alkyl; and l represents a pharmacologically inactive linker moiety having 10-50 atoms; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same as well as to the use of said kisspeptide-pentasaccharide conjugates in the treatment of female infertility.. .
| Treatment of prostate cancer and a method for determining the prognosis for prostate cancer patients|
The present invention relates to a wnt5a protein or peptide thereof possessing wnt5a signaling properties, such as foxy5, for use in the treatment of prostate cancer, in particular in patients that have undergone or will undergo radical prosteatectomy. The invention also relates to a method for determining a prognosis for a patient having prostate cancer and a kit for performing said method.
| Stable peptide-based pace4 inhibitors|
It is provided pace4 inhibitors and their uses for treating infection, cancer. Particularly, it is provided a method or use for the treatment of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the pace4 inhibitors or the composition disclosed..
| Cancer therapy method|
This invention describes a method for treating cancer by increasing the nuclear localization of the commd1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the commd1 protein, in the manufacture of a medicament for cancer therapy.
| T cell receptors and related materials and methods of use|
The invention provides t cell receptors (tcrs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions.
| Peptide for inducing regeneration of tissue and use thereof|
(means for solution) multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a pdgfrα-positive bone marrow mesenchymal stem cell line (msc-1).
| Glucagon/glp-1 receptor co-agonists|
Provided herein are peptides and variant peptides that exhibit enhanced activity at the glp-1 receptor, as compared to native glucagon.. .
| 4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication|
The variables are defined herein. Certain compounds of formula i are useful as antiviral agents.
| Engineered polypeptide agents for targeted broad spectrum influenza neutralization|
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (ha) polypeptides and/or ha receptors, and reagents and methods relating thereto.
| Design of ph-sensitive oligopeptide complexes for drug release under mildly acidic conditions|
The present invention discloses a design for a molecular delivery vehicle capable of delivering a molecular payload to a target cell and its intracellular compartments. Also disclosed are highly ph-sensitive nanoconstruct that takes advantage of the requirement of cationic charge for internalization of cpps to mask the non-specific internalization, compositions containing nanoconstruct, and methods for forming the same..
| Polypeptides having protease activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
| Universal fibronectin type iii binding-domain libraries|
Walk-through mutagenesis and natural-variant combinatorial fibronectin type iii (fn3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens..
| Biomarkers for psoriasis|
A group of polypeptides that are modulated in a psoriatic sample as compared to a normal sample is provided. These polypeptides can be used as biomarkers for diagnosis and monitoring treatment of psoriasis..
| Nucleic acid construct, nucleic acid-protein complex, and use thereof|
Using a nucleic acid construct, association of a polypeptide with a sequence coding therefor and screening of a polypeptide that binds to a target substance are carried out, which nucleic acid construct comprises a 5′-untranslated region and a coding region, wherein the above-mentioned coding region comprises a sequence coding for a polypeptide subjected to be displayed, a sequence coding for a first nucleic acid binding polypeptide, and a sequence coding for a second nucleic acid binding polypeptide; the above-mentioned 5′-untranslated region comprises a first sequence capable of binding to a first nucleic acid binding polypeptide and a second sequence capable of binding to second nucleic acid binding polypeptide; and, when the above-mentioned nucleic acid construct is introduced in a translation system, a fusion protein translated from the coding region of the above-mentioned nucleic acid construct forms a complex with an rna corresponding to the above-mentioned nucleic acid construct.. .
| Systems and methods for identifying replikin scaffolds and uses of said replikin scaffolds|
The present invention provides a new class of peptides related to rapid replication and high human mortality, and their use in diagnosing, preventing and treating disease including vaccines and therapeutics for emerging viral diseases and methods of identifying the new class of peptides and related structures.. .
| Maldi mass spectrometry method|
The problem is to provide a maldi mass spectrometry method that can be used for a mass spectrometry method by a general maldi method with which it is possible to measure multiple molecules to be measured that are contained in a sample quantitatively in a short period of time with good efficiency compared with conventional methods. The problem is solved by a maldi mass spectrometry method for a sample containing multiple molecules to be measured, which is a maldi mass spectrometry method characterized in that the multiple molecules to be measured are a saccharide mixture, a glycopeptide mixture, a glycopeptide-peptide mixture, a glycoprotein mixture, or a glycoprotein-protein mixture, and that a quantitative mass spectrum of the multiple molecules to be measured is obtained from an arbitrary point in the sample to be measured where a signal is detected without measuring and integrated averaging the entire sample to be measured..
| Cross-linking compositions and related methods of isotope tagging of interacting proteins and analysis of protein interactions|
An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (itip), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the ms/ms spectrum.
| Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins|
The present invention relates to the use of variable domains of camelid heavy-chain antibodies (vhh domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns vhh domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents..
| Vector with codon-optimised genes for an arabinose metabolic pathway for arabinose conversion in yeast for ethanol production|
The present invention relates to novel expression cassettes and expression vectors, comprising three nucleic acid sequences for araa, arab and arad, each coding for a polypeptide of an l-arabinose metabolic pathway, in particular, a bacterial l-arabinose metabolic pathway. The invention particularly relates to expression cassettes and expression vectors, comprising codon-optimised nucleic acid sequences for araa, arab and arad.
| Bioactive carbon nanotube composite functionalized with b-sheet polypeptide block copolymer, and preparation method thereof|
The present invention relates to a bioactive carbon nanotube composite functionalized with a β-sheet polypeptide block copolymer by combination self-assembly, which shows excellent water dispersion, and has biological activity so as to be used as stimulus-responsive and adaptable biomaterials or in the manufacture of cnt-based electronic biosensor devices. In addition, the bioactive carbon nanotube composite can be used as a composition for delivery of a biological active material into cells.
| Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy|
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell.
| Use of proline specific endoproteases to hydrolyse peptides and proteins|
The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a ph of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.. .
| Polypeptides having glucoamylase activity and polynucleotides encoding same|
Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains..
| Method for quantification of allergens|
C) quantifying the absolute amount of allergen by correlating the amount of the allergen calibration standard peptide(s) with the amount of the corresponding peptide(s) of the degraded allergen sample by mass analysis.. .
| Methods, kits & antibodies for detecting intact fibroblast growth factor 21|
Disclosed are methods, compositions and kits related to immunoassays for detection of fgf21 using antibodies specific to the n-terminal and/or c-terminal of fgf21. The present invention provides antibodies specific to n-terminal or c-terminal peptide of fgf21.
| Fc-function assay|
The present invention discloses a method of assaying fc-function in an immunoglobulin containing sample by contacting the sample, in the presence of a complement, with red blood cells modified to incorporate a f-s-l peptide-lipid construct. The f-s-l peptide construct comprises a functional group (f) that is a target antigen for a complement activating immunoglobulin, a spacer group (s) covalently linking f to l and a lipid group (l).
| Antibodies against fatty acid synthase|
The present invention relates to antibodies that immunospecifically bind to fas and certain fas related proteins. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders.
| Lysyl oxidase-like 2 assay and methods of use thereof|
The present disclosure provides an assay to detect and/or quantify circulating lysyl oxidase-like 2 (loxl2) poly-peptides in an individual. The assay is useful in diagnostic and prognostic applications, which are also provided..
| Flavor composition and edible compositions containing same|
A flavor composition containing at least one dipeptide or tripeptide compound that can be used to enhance the taste of edible compositions including sweet goods, such as confectionery goods, and savory goods, such as pet foods.. .
| Fermentation of fruit juices|
A method of introducing yeast into a fruit juice such as grape must to be fermented is disclosed. The method comprises feeding dry yeast into a flowing stream of the fruit juice and delivering the flowing stream of fruit juice with the yeast in it to a mixer (10).
| Dipeptides as feed additives|
The invention relates to feed additives containing dipeptides or salts thereof, in which one amino acid residue of the dipeptide is a dl-methionyl residue and the other amino acid residue of the dipeptide is an amino acid in the l-configuration selected from lysine, threonine, tryptophan, histidine, valine, leucine, isoleucine, phenylalanine, arginine, cysteine and cystine; feed mixtures containing these additives and method of producing the dipeptides.. .
| Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation|
The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed..
| Novel method and compositions|
The present invention relates to, inter alia, a method of raising an immune response against a pathogen which comprises administering (i) one or more first immunogenic polypeptides derived from said pathogen; (ii) one or more adenoviral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from said pathogen; and (iii) an adjuvant; wherein the one or more first immunogenic polypeptides, the one or more adenoviral vectors and the adjuvant are administered concomitantly. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing said polypeptides, adenoviral vectors and adjuvants..
| Stimulation of vaccination by angiotensin peptides|
The present invention provides angiotensin peptide compositions and methods for use of the compositions in vaccination.. .
| Methods to increase antigenicity of membrane-bound polypeptides produced in plants|
Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds from the plant is such that phospholipids are associated with the polypeptide. Reducing fat by supercritical fluid extraction increases antigenicity of such plant-produced membrane-bound polypeptides.
| Vaccines against influenza virus|
Were m2e is the influenza m2 ectodomain (m2e) peptide; cys is a cysteine amino acid residue present in the m2e peptide; s the sulfur present in the cysteine amino acid residue; ch2-co—nh—ch2-ch2-co the linking group; nh the amine group present in a lysine residue of the carrier; lys is a lysine amino acid residue and pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza ha protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza ha protein has been modified to remove an n-terminal leader amino acid sequence and a c-terminal transmembrane domain.
| Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders|
The present invention relates to amino acid sequences that are directed against rank-l, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes..
| Polypeptide that binds aberrant cells and induces apoptosis|
Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an mhc-peptide complex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes.
| Multimeric il-15 soluble fusion molecules and methods of making and using same|
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (il-15) polypeptide or a functional fragment thereof.
| Collecting and processing complex macromolecular mixtures|
This document provides methods and materials involved in collecting and processing complex macromolecular mixtures (e.g., stool samples). For example, stool collection devices, buffers for stabilizing nucleic acid and polypeptides present in stool, and kits for using sequence-specific capture probes (e.g., nucleic acid sequences designed to hybridize with particular target nucleic acids) to capture target nucleic acids directly from complex macromolecular mixtures (e.g., stool samples) without the need to perform prior steps to enrich, isolate, or purify the nucleic acid component are provided..