|| List of recent Peptide-related patents
| Plants having enhanced yield-related traits and making the same|
A method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid up-regulated upon overexpression of a nac1 or nac5-encoding gene, referred to herein as a nug or nac up-regulated gene, is provided. Plants having modulated expression of a nug, which plants have enhanced yield-related traits relative to corresponding wild type plants or other control plants, are also provided.
Crop Functional Genomic Center
| Prephenate dehydrogenases and arogenate dehydrogenases that are insensitive to effector feedback inhibition and methods of using the same|
Prephenate dehydrogenases and arogenate dehydrogenase polynucleotide and polypeptide sequences are provided herein. These polypeptides are all insensitive to effector based feedback inhibition.
Wisconsin Alumni Research Foundation
| Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase|
The invention relates to a polypeptide comprising an amino acid having a bicyclo[6.1.0]non-4-yn-9-ylmethanol (bcn) group, particularly when said bcn group is present as: a residue of a lysine amino acid. The invention also relates to a method of producing a polypeptide comprising a bcn group, said method comprising genetically incorporating an amino acid comprising a bcn group into a polypeptide.
Medical Research Council
| Gamma amino acid building blocks|
The michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The michael adducts can be efficiently converted to cyclically constrained protected γ-amino acid residues, which are essential for systematic conformational studies of γ-peptide foldamers.
| Single-chain insulin agonists exhibiting high activity at the insulin receptor|
Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can be used to link human insulin a and b chains, or analogs or derivatives thereof, wherein the carboxy terminus of the b25 amino acid of the b chain is linked to the amino terminus of the a1 amino acid of the a chain via the intervening linking moiety.
Indiana University Research And Technology Corporation
| Prostacyclin compounds, compositions and methods of use thereof|
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described.
| Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators|
The present invention relates to novel amide derivatives of n-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the n-formyl peptide receptor like-1 (fprl-1) receptor.. .
| Method for inhibiting growth of cancer cells|
A method of inhibiting the growth of cancer cells is disclosed in which cancer cells that contain an enhanced amount relative to non-cancerous cells of one or more of phosphorylated mtor, akt1, erk2 and serine2152-phosphorylated filamin a are contacted with an flna-binding effective amount of a compound or a pharmaceutically acceptable salt thereof that binds to the pentapeptide of filamin a (flna) of seq id no: 1 and exhibits at least about 60 percent of the fitc-labeled naloxone binding amount when present at a 10 μm concentration and using unlabeled naloxone as the control inhibitor at the same concentration. A compound that binds to the flna pentapeptide preferably also contains at least four of the six pharmacophores of figs.
Pain Therapeutics, Inc.
| Novel peptides and analogs for use in the treatment of macrophage activation syndrome|
Innate defense regulators (idrs) interact with intracellular signaling events and modulate the innate defense response. Whereas much of the initial work with the idrs focused on their role in fighting infection, recent results in animal models of chemotherapy- or radiation-induced mucositis and wound healing suggest that idrs can be beneficial during the responses to a broader range of damage-inducing agents beyond pathogens.
| Peptides effectife in the treatment of conditions requiring the removal or destruction of cells|
The embodiments are directed to peptides, compositions, and methods of treating conditions requiring removal or destruction of harmful or unwanted cells in a patient, such as benign and malignant tumors, using compounds containing or based on peptides.. .
Peptide inhibitors of caspase 2 activation
The present invention relates to compositions, including membrane permeable complexes, comprising a caspase 2 activation inhibitory peptide having the amino acid sequence afdafc as well as methods of using the same for the treatment of neurodegenerative conditions associated with apoptosis in the central nervous system, such as alzheimer's disease, mild cognitive impairment, parkinson's disease, amyotrophic lateral sclerosis, huntington's chorea, and creutzfeld-jacob disease.. .
The Trustees Of Columbia University In The City Of New York
Method and pharmaceutical composition for hair growth
The present disclosure relates to a method and a pharmaceutical composition for hair growth. The pharmaceutical composition includes a hair growth peptide (hgp) which includes all or part of the amino acid sequence seq id no: 1.
Industrial Technology Research Institute
Oleanoyl peptide composition and collagen enhancement
Disclosed is the a method of skin repair and firming, said method comprising the step of bringing into contact a pentapeptide conjugate of oleanolic acid with skin cells so that the effect of increased cellular communication at the molecular level to bring about gene and protein expression in the cells of the skin that enable repair and firming is realized. The invention demonstrates the effect of the pentapeptide conjugate of oleanolic acid in increasing transforming growth factor-β and fibroblast growth factor gene expressions in the skin..
Controlled-released peptide formulations
Described herein are methods and compositions for modulating the release and/or drug loading characteristics of encapsulated bioactive agents in polymer-based delivery systems via direct modification of the isoelectric point and/or net charge of the bioactive agent.. .
Corden Pharma, Ltd.
Fibroblast growth factor mutants having improved functional half-life and methods of their use
Mutant fibroblast growth factor (fgf) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human fgf-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human fgf-1 with a tryptophan (based on the 140 amino acid numbering scheme of human fgf-1) are provided. Other amino acid mutations or substitutions may be combined.
Florida State University Research Foundation
Long-acting polypeptides and methods of producing and administering same
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (ctp) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed..
Opko Biologics Ltd.
Toxic peptide production, peptide expression in plants and combinations of cysteine rich peptides
New insecticidal proteins, nucleotides, peptides, their expression in plants, methods of producing the peptides, new processes, production techniques, new peptides, new formulations, and new organisms, a process which increases the insecticidal peptide production yield from yeast expression systems. The present invention is also related and discloses selected endotoxins we call cysteine rich insecticidal peptides (crips) which are peptides derived from bacillus thuringiensis (bt) and their genes and endotoxins in combination with toxic peptides known as inhibitor cystine knot (ick) genes and peptides as well as with other types of insecticidal peptides such as trypsin modulating oostatic factor (tmof) peptide sequences used in various formulations and combinations; of both genes and peptides, useful for the control of insects..
Salt and protease-resistance of antimicrobial peptide and the manufacture thereof
The present invention provides an antimicrobial peptide, wherein the amino terminal and/or carboxyl terminal of the peptide is linked with at least one artificial bulkyl amino acid to increase the salt resistance and protease resistance of the antimicrobial peptide. The antimicrobial peptide of the invention has a high salt resistance, a high protease resistance, and a low hemolytic activity, simultaneously..
National Tsing Hua University
Analyte mass spectrometry quantitation using a universal reporter
Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.. .
Surface anchored light chain bait antibody display system
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host.
Merck Sharp & Dohme Corp.
Methods and compositions for personalized medicine by point-of-care devices for brain natriuretic peptide
Methods, devices, reagent, systems and kits for the detection, diagnosis of ovarian cancer as well as for the monitoring of ovarian cancer progression and for monitoring the progress of ovarian cancer treatments using bnp as a biomarker.. .
Serological markers for cancer diagnosis using blood sample
The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein involved in cancer progress. More particularly, the present invention relates to a cancer diagnosis peptide marker which is screened by the steps of: separating a glycoprotein aberrantly glycosylated according to the occurrence and progress of cancer from the blood of a lung cancer patient by using lectin; and selecting a marker peptide produced by the hydrolysis of the glycoprotein isolated by lectin.
Korea Basic Science Institute
Polypeptide substrate for the detection of von williebrand factor cleaving protease adamts13
In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (adamts13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von willebrand factor a2 domain sequence set forth in seq id no:2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of seq id no: 2 is mutated from q to k; (ii) the amino acid corresponding to position 1610 of seq id no: 2 is mutated from n to c; and (iii) the amino acids corresponding to q1624 to r1641 of seq id no: 2 are deleted. In another aspect, there is provided an adamts13 polypeptide substrate that is from 50 to 75 amino acids in length and has an amino acid sequence that is substantially similar to part of the von willebrand factor a2 domain sequence set forth in seq id no:2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of seq id no: 2 is mutated from q to k; (ii) the amino acid corresponding to position 1610 of seq id no: 2 is mutated from n to c; (iii) the amino acid corresponding to position 1629 of seq id no: 2 is mutated from g to e; and (iv) the amino acids corresponding to g1631 to r1641 of seq id no: 2 are deleted..
Dot1 histone methyltransferases as a target for identifying therapeutic agents for leukemia
The present invention provides polypeptides with histone h3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest.
The University Of North Carolina At Chapel Hill
Ledgf peptides and formulations thereof for treatment of degenerative disorders
Ledgf peptides with anti-protein aggregation activity and methods of use are provided. The ledgf peptides disclosed herein demonstrate an ability to treat degenerative diseases and diseases with various cellular stresses including oxidative stress and protein-aggregation stress.
The Regents Of The University Of Colorado, A Body Corporate
Methods and compositions for oral administration of protein and peptide therapeutic agents
The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide..
Oshadi Drug Administration Ltd.
Method of inducing antibodies to human immunodeficiency virus involving the administration of mper peptide-liposome conjugates
The present invention relates to a method of inducing the production in a patient of anti-hiv antibodies. The method comprises administering to a patient in need thereof an amount of at least one liposome-peptide conjugate in an amount sufficient to effect that induction.
Sustained delivery of molecules using peptide surfactants and uses thereof
The present invention is directed to a drug delivery composition comprising a self-assembled nanostructure and biologically active molecule, wherein the nanostructure comprises surfactant peptides, and wherein the biologically active molecule is encapsulated in the nanostructure. The invention also encompasses methods of administering a biologically active molecule to a subject comprising administering the drug delivery composition and methods for the preparation of said composition..
Massachusetts Institute Of Technology
The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host.
Dsm Ip Assets B.v.
Immunogenic compounds comprising hiv gp41 peptide coupled to crm197 carrier protein
The present invention relates to the field of vaccines directed against viruses of the hiv family. More particularly, it relates to an immunogenic compound comprising a peptide of the following formula (i) nh2-[nt]y-p-w-n-x-s-x2-s-n-x3-x4-x-x6-x7-i-w-[ct]z-cooh (i) which is covalently linked to a carrier protein consisting of a crm197 protein.
Novel immunotherapy against several tumors including gastrointestinal and gastric cancer
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh
Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease..
New York University
Bordetella outer-membrane protein antigens and methods of making and using the same
An isolated protein or peptide selected from the group consisting of bordetella colonization factor a (bcfa) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.. .
Wake Forest University Health Sciences
Influenza treatment and/or characterization, human-adapted ha polypeptides; vaccines
The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.. .
Massachusetts Institute Of Technology
Serpin fusion polypeptides and methods of use thereof
This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an fc polypeptide or an amino acid sequence that is derived from an fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a wap domain containing polypeptide or a sequence derived from a wap containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules..
Wap domain fusion polypeptides and methods of use thereof
This invention relates to fusion proteins that include a whey acidic protein (wap) domain-containing polypeptide and a second polypeptide. Additionally, the invention relates to fusion proteins that include a wap domain-containing polypeptide a second polypeptide, and a third polypeptide.
N-terminal derivatisation of proteins with polysaccharides
The present invention relates to methods for producing n-terminal derivatives of proteins in which a polysaccharide, preferably having at least terminal sialic units, and preferably consisting essentially only of sialic acid units, is reacted at the n-terminus of a protein or peptide under controlled conditions to produce an n-terminal derivative. The controlled conditions include use of acidic ph for the derivatisation step and a higher ph for purification.
Lipoxen Technologies Limited
The same sample s is analyzed using an ion-trap (it) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (tof) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an it mass spectrum and a tof mass spectrum from the measured results.
Nucleic acid molecules encoding polypeptides involved in regulation of sugar and lipid metabolism and methods of use viii
This invention relates generally to nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to arabidopsis thaliana, brassica napus, glycine max and oryza sativa nucleic acid sequences encoding sugar and lipid metabolism regulator proteins and the use of these sequences in transgenic plants.
Basf Plant Science Gmbh
Nucleic acid molecules and other molecules associated with plants and uses thereof
Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
Monsanto Technology Llc
Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased tolerance to abiotic stress (e.g., high or low temperature, drought, flood).. .