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Peptide patents



      
           
This page is updated frequently with new Peptide-related patent applications. Subscribe to the Peptide RSS feed to automatically get the update: related Peptide RSS feeds. RSS updates for this page: Peptide RSS RSS


Date/App# patent app List of recent Peptide-related patents
03/26/15
20150089687
 Novel antifungal proteins and methods of use patent thumbnailnew patent Novel antifungal proteins and methods of use
Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for novel variants of antipathogenic polypeptides generated through dna shuffling that exhibit improved antipathogenic activity.
Pioneer Hi Bred International Inc
03/26/15
20150087816
 Doped materials for reverse phase chromatography patent thumbnailnew patent Doped materials for reverse phase chromatography
A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 μmol/m2 to 0.8 μmol/m2 referred to the surface of the solid support for a material with a total amount of surface modifying groups of 3.6 μmol/m2. Such material and suitable purification conditions for active pharmaceutical ingredients (apis) like peptides can be evaluated by (a) determining the isoelectric point (pi) of the api of interest, (b) choosing a ph in a range where the solid phase material is stable, (c) determining the difference pi-ph and (d) if the difference pi-ph is positive, choosing an anion exchange (aiex) material, or if the difference pi-ph is negative, choosing an cation exchange (ciex) material..
Zeochem Ag
03/26/15
20150087815
 Vaccine compositions patent thumbnailnew patent Vaccine compositions
The present disclosure relates to vaccine compositions, particularly klh-peptide conjugates, and methods of making such compositions. The present disclosure further relates to methods of reducing abnormal cell growth using the compositions described herein..
Celldex Research Corporation
03/26/15
20150087811
 Glycoprotein synthesis and remodeling by enzymatic transglycosylation patent thumbnailnew patent Glycoprotein synthesis and remodeling by enzymatic transglycosylation
A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of glcnac-protein and glcnac-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (engase), to transfer the oligosaccharide moiety to the acceptor and yield the homogeneous glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline.
University Of Maryland, Baltimore
03/26/15
20150087810
 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof patent thumbnailnew patent Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (mmp), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one mmp protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one mmp protease in a variety of therapeutic, diagnostic and prophylactic indications.. .
Cytomx Therapeutics, Inc.
03/26/15
20150087809
 Hla-binding peptides, precursors thereof, dna fragments and recombinant vectors that code for those peptide sequences patent thumbnailnew patent Hla-binding peptides, precursors thereof, dna fragments and recombinant vectors that code for those peptide sequences
An hla-binding peptide binding to an hla-a type molecule, said hla-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of seq id nos: 1 to 183, and not less than 8 and not more than 11 amino acid residues is provided. Any of the amino acid sequence is predicted to have the binding property to a human hla-a type molecule by a predicting program using an active learning experiment method as illustrated in fig.
Kochi University
03/26/15
20150087808
 Process for the manufacture of cyclic undecapeptides patent thumbnailnew patent Process for the manufacture of cyclic undecapeptides
The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as alisporivir.. .
Novartis Ag
03/26/15
20150087807
 Lipopolysaccharide-targeted peptide mimic vaccine against q fever patent thumbnailnew patent Lipopolysaccharide-targeted peptide mimic vaccine against q fever
A vaccine and method of vaccination for conferring immunity to q fever is described. The vaccine comprises a polypeptide with a sequence of sltwhkhelhrk (m1e41920) or sppwhkhelhrk (m1e44), or at least 90% identity to m1e41920 or m1e44.
03/26/15
20150087806
 Glycopeptide and uses thereof patent thumbnailnew patent Glycopeptide and uses thereof
A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof..
University Of Georgia Research Foundation, Inc.
03/26/15
20150087755
 Isoindolo[2, 1-a]quinazoline derivatives for stabilization of organic materials patent thumbnailnew patent Isoindolo[2, 1-a]quinazoline derivatives for stabilization of organic materials
The present invention relates to a composition, which comprises a) an organic material susceptible to oxidative, thermal or light-induced degradation, which is a polymer, an oligohydroxy compound, a wax, a fat or a mineral oil, with the proviso that the polymer is not a polypeptide, agar-agar or a component of agar-agar and the oligohydroxy compound is not glucose or a component of agar-agar; and b) a compound of formula (i) n is 1, 2, 3 or 4; when n is 1, r5 is h, c1-c30-alkyl, c3-c10-cycloalkyl, c6-c10-aryl, which is unsubstituted or substituted by c1-c8-alkyl, c1-c8-alkoxy, halogen or one phenyl, c7-c13-aralkyl, c2-c22-alkenyl, c3-c12-alkinyl, oh, c1-c30-alkyloxy, c3-c10-cycloalkyloxy, c6-c12-aryloxy, c7-c13-aralkyloxy, hydroxy-c1-c8-alkyl, carboxy-c1-c12-alkyl, c1-c12-alkoxycarbonyl-c1-c12-alkyl, c2-c30-alkyl, which is interrupted by one or more oxygen atoms, c2-c16-alkyl, which is interrupted by one sulfur atom, or nr′1r′2; when n is 2, r5 is c1-c12-alkane-diyl, c6-c14-arylene, c4-c8-cycloalkane-bis-(c1-c4-alkylene), c6-c14-arene-bis-(c1-c4-alkylene), c4-c24-alkane-diyl, which is interrupted by one or more oxygen atoms, c4-c20-alkane-diyl, which is interrupted by one or more —nh—, —n(c1-c8-alkyl)- or —n(hydroxy-c1-c8-alkyl)-, piperazine-n,n′-bis-(c1-c4-alkylene) or c2-c10-alkane-diyl, which is interrupted by one sulfur atom; r1 to r4 and r6 to r9 are each independently from each other h, c1-c12-alkyl, c3-c10-cycloalkyl, c3-c22-alkenyl, c1-c12-alkoxy, c1-c12-alkylsulfanyl, hydroxy-c1-c8-alkyl, halogen, nr″1r″2, no2, cn, phenyl, phenyloxy or r1 and r2 or r2 and r3 or r3 and r4 or r6 and r7 or r7 and r8 or r8 and r9 are linked together to form a five- or 6-membered alicylic, aromatic or heterocyclic ring together with their 2 corresponding carbons atoms, to which they are attached.. .
Basf Se
03/26/15
20150087690
new patent

G protein-coupled purinergic receptor gpr17 mediates orexigenic effects of foxo1 in agrp neurons


G protein-coupled receptor (gpcr) gpr17 expressed in hypothalamic agouti-related peptide-expressing (agrp) neurons increases appetite and glucose tolerance and insulin sensitivity. By contrast, increasing gpr17 reduced glucose tolerance and increased appetite.
The Trustees Of Columbia University In The City Of New York
03/26/15
20150087642
new patent

Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions


Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.. .
Satiogen Pharmaceuticals, Inc.
03/26/15
20150087606
new patent

Pharmaceutical composition for preventing or treating amyloid beta peptide-associated diseases or conditions


A pharmaceutical composition containing isoacteoside to the acteoside is provided, which is able to inhibit formation, accumulation or aggregation of amyloid β peptides, and is thus useful in preventing or treating amyloid beta peptide-associated diseases or conditions, wherein a weight ratio of the isoacteoside to the acteoside is 4:1 to 1:4.. .
Sinphar Tian-li Pharmaceutical Co., Ltd. (hangzhou)
03/26/15
20150087604
new patent

Anti-fatty acid synthase polypeptide and use thereof


The present invention relates to a polypeptide that is capable of inhibiting transcription and expression of fatty acid synthase (fas) and the polynucleotides encoding therefor, as well as the use thereof. Specifically, the present invention relates to a polypeptide that can inhibit the transcription and expression of fas at the molecular level, the cellular level and in vivo, and can therefore prevent the overexpression of fas.
Tianjin Toptech Bio-science & Technology Co., Ltd.
03/26/15
20150087603
new patent

Modified peptide toxins


The invention relates to toxin peptides capable of selectively inhibiting a kv1.3 potassium channel protein. The toxin peptides of the invention are modified anuroctonus scorpion toxin peptides..
University Of Debrecen
03/26/15
20150087599
new patent

Peptide-conjugated oligonucleotide therapeutic and making and using same


In which the peptide is a homing peptide which directs the conjugate to cells of a particular type, antisense is an antisense oligonucleotide having a sequence selected to provide sequence-specific inhibition of the target protein, and hbl is a heterobifunctional linker having reactivity towards amino and sulfhydryl groups.. .
03/26/15
20150087598
new patent

Treating muc1-expressing cancers with helicase inhibitors


The invention provides method of treating cancers that express muc1 by the administration of eif4a helicase inhibitors. These inhibitors may advantageously be combined with peptides that inhibit muc1 oligomerization, or with other standard anticancer therapies such as chemo-, radio- and surgical therapies..
Dana-farber Cancer Institute, Inc.
03/26/15
20150087597
new patent

Polypeptides and methods of use


Described herein are fragments of fibronectin and vitronectin and variants thereof that have certain activities, including growth factor-binding activity. Also described are fragments of growth factors that bind to fibronectin and inhibit binding of full-length growth factors to fibronectin.
The Research Foundation For The State University Of New York
03/26/15
20150087596
new patent

Huwentoxin-iv variants and methods of use


The present invention relates to huwentoxin-iv variants, polynucleotides encoding them, methods of making and using the foregoing, and methods of alleviating pain with peptide inhibitors of nav1.7.. .
Janssen Biotech, Inc.
03/26/15
20150087595
new patent

Methods and compositions for the prevention and treatment neuropathy


The disclosure relates to methods for treating a subject suffering from hyperalgesia caused by drug-induced neuropathy by administering to the subject an effective amount of an aromatic-cationic peptide. The disclosure also relates to methods for protecting a subject from hyperalgesia caused by drug-induced neuropathy by administering an effective amount of an aromatic-cationic peptide to a subject at risk for developing the condition..
Stealth Peptides International, Inc.
03/26/15
20150087591
new patent

Novel composition for extracorporeal reduction of beta-amyloids and process for producing thereof


The present invention provides a safe, reliable, and economical process for preparing an improved dialysis fluid formulation effective for extracorporeal treatment, through a blood filtration process, of a beta-amyloid associated pathological condition in a subject, said process comprises preparing a composition comprising klvff peptide, or a variant thereof, as the capturing and binding agent, and a carrier therefor, and mixing said composition with a dialysate solution. The process utilizes a compact, inexpensive, and simple standard dialysis machine that extracorporeally removes beta-amyloids without allowing escape of the beta-amyloids back into a subject's body, without having to intricately evaluate the performance and characteristics of a dialysis membrane, and without putting the health condition of the subject at risk..
Amylex Pharmaceuticals, Inc.
03/26/15
20150087586
new patent

Pegylated c-peptide


The present invention relates to modified forms of c-peptide, and methods for their use. In one aspect, the modified forms of c-peptide comprise conjugated c-peptide derivatives which exhibit superior pharmacokinetic and biological activity in vivo..
Cebix, Inc.
03/26/15
20150087581
new patent

Immunosuppression modulating compounds


The present invention provides immunosuppression compounds to inhibit the programmed cell death 1 (pd1) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signaling induced by pd-1, pd-l1, or pd-l2 and therapies using them, immunopotentiative substrates included as the active ingredient.
Aurigene Discovery Technologies Limited
03/26/15
20150087580
new patent

Antimicrobial cationic peptides and formulations thereof


Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device..
Carrus Capital Corporation
03/26/15
20150087579
new patent

Antimicrobial peptides


A novel antimicrobial peptide includes at least eight successive amino acids, the peptide exhibiting a sequence having the following formula: ter1-x1-b1-x2-b2-x3-z1-z2-x4-ter2. The peptide can moreover also have modified termini.
Robert Bosch Gensellschaft FÜr Medizinische Forschung Mbh
03/26/15
20150087555
new patent

Method for immobilizing biologic molecules on solid surfaces


The invention provides a method for immobilization of biological molecules such as nucleic acids, peptides and proteins onto the surface of a glass or plastic solid support.. .
03/26/15
20150087554
new patent

Polypeptide markers for the diagnosis of alzheimer's disease


A method for the diagnosis of the probability of alzheimer's disease in a subject patient comprising the step of determining the presence or absence of at least three polypeptide markers in a sample, wherein the at least three polypeptide markers are at least three different markers selected from markers 1 to 50 (frequency markers) and markers 51 to 279 (amplitude markers), wherein the diagnosis is based on a comparison and ranking of the frequency and/or amplitude of the at least three polypeptide markers to the same at least three polypeptide markers obtained from control subjects with and without alzheimer's disease.. .
Mosaiques Diagnostics And Therapeutics Ag
03/26/15
20150087533
new patent

Ligand screening and discovery


Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second coding region encoding a second immunoglobulin variable domain, and c) a ribosomal binding site disposed between the first and second coding regions for translation of the second polypeptide in a first expression system, wherein the first and second coding regions are in the same translational orientation; (ii) modifying each nucleic acid cassette of the plurality in a single reaction mixture so that it is functional in a second expression system, wherein the first and second region remain physically attached during the modifying; (iii) introducing each modified nucleic acid cassette into a mammalian cell to produce a mixture of transfected cells; and (iv) expressing each modified nucleic acid cassette in the transfected cells.. .
Dyax Corp.
03/26/15
20150087526
new patent

Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation


The present disclosure provides peptide amino acid sequencing and identification methods and kits for performing such methods. For example, single-molecule detection of fluorophore-labeled peptides is disclosed using multiple rounds of standard edman degradation or using digestion by chemicals or enzymes.
The Regents Of The University Of Colorado, A Body Corporate
03/26/15
20150087073
new patent

Methods for quantifying polypeptides using mass spectrometry


A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of comprising an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent comprising an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent comprising an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole..
Waters Technologies Corporation
03/26/15
20150087047
new patent

Process for production of recombinant proteins as a soluble form


A target protein is prepared as soluble protein using a recombinant protein expression system. An expression vector is used that includes (1) an expression-inducible promoter sequence; (2) a first coding sequence including a polynucleotide coding for a polypeptide that is represented by the formula (z)n; and (3) a second coding sequence that includes a polynucleotide that codes for a target protein.
Jnc Corporation
03/26/15
20150087003
new patent

Method for obtaining peptides


The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.. .
Commissariat à I'energie Atomique Et Aux Energies Alternatives
03/26/15
20150087002
new patent

Methods and kits for detection of o-glcnac and n-glcnac modification of peptides and proteins


Methods and kits for detecting the presence of glcnac modification of a peptide or protein. The steps of detection may include combining the peptide or protein with pap35s and a sulfotransferase to produce a reaction product including 35s labeled glcnac modified protein or peptide, removing background labeling with a glycosidase, separating the 35s labeled glcnac modified protein or peptide from pap35s, free s-35 sulfate and labeled oligosaccharides if present, and detecting isotopic emissions from the 35s labeled glcnac modified peptide or protein.
Research And Diagnostic Systems, Inc.
03/26/15
20150087000
new patent

Diagnostic kits to detect sp22 and sp22 antibodies


Oral, topical and injectable contraceptives, which are based on sperm protein 22 kda (sp22) polypeptides and antibodies and infertility diagnostics and kits are provided.. .
U.s. Environmental Protection Agency
03/26/15
20150086636
new patent

Myostatin inhibition for enhancing muscle and/or improving muscle function


The present invention relates to methods for inhibiting myostatin, a regulator of muscle mass, for muscle enhancement (including inducing hypertrophy and/or hyperplasia) as well as improving muscle function (including decreasing atrophy and/or increasing endurance, force and/or strength). Some of the methods involve delivering genes to cells using gene delivery or other delivery techniques known in the art in order to inhibit myostatin.
Nationwide Children's Hospital
03/26/15
20150086617
new patent

Liposome structures and methods of use thereof


The present application relates to compositions comprising and methods of using a liposome comprising a phlip polypeptide, wherein a lipid bilayer of the liposome is substantially free of the phlip polypeptide.. .
Yale University
03/26/15
20150086611
new patent

Liposome including complex of hydrophobic active ingredient and polypeptide and use of the liposome


A liposome comprising a lipid bilayer encapsulating a complex containing a hydrophobic active ingredient and a polypeptide, a pharmaceutical composition including the liposome, and a method of delivering an active ingredient to a target site in the body of a subject.. .
Samsung Electronics Co., Ltd.
03/26/15
20150086589
new patent

Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof


The present invention relates to novel virus-like particles (vlps) comprising a matrix protein derived from a first plant enveloped virus and a surface polypeptide. The surface polypeptide comprises (a) a surface exposed portion derived from a target polypeptide (b) a transmembrane domain, and (c) a cytosolic tail derived from a transmembrane (e.g., glycoprotein) of a second plant enveloped virus.
Fraunhofer Usa Inc.
03/26/15
20150086588
new patent

Parainfluenza virus 5 based vaccines


The present invention provides safe, stable, efficacious, and cost-effective vaccines based on viral expression vectors that include a parainfluenza virus 5 (piv5) genome including a heterologous nucleotide sequence expressing a heterologous polypeptide. In some embodiments, the heterologous nucleotide sequence is inserted closer to the leader than between the hemagglutinin-neuroaminidase (hn) gene and the large rna polymerase protein (l) gene of the piv5 genome.
University Of Georgia Research Foundation, Inc.
03/26/15
20150086583
new patent

Mucin-associated surface protein as vaccine against chagas disease


Use of synthetic peptides derived from trypanosoma cruzi antigens and their use in vaccination against trypomastigote infection and chagas disease. T.
Board Of Regents, The University Of Texas System
03/26/15
20150086578
new patent

Human cytomegalovirus vaccine


Combination peptides, polypeptides and proteins that elicit high titer neutralizing antibodies against cytomegalovirus (cmv) are provided. The combination peptides, polypeptides and proteins encompass epitopes located within the ul130 and ul131 components of the gh/gl/ul128-131 protein complex, in particular, epitopes located within amino acid residues 27-46 of ul130 and amino acid residues 90-106 of ul131.
Virginia Commonwealth University
03/26/15
20150086576
new patent

Sortase-modified vhh domains and uses thereof


In some aspects, polypeptides comprising single domain antibodies and methods of identifying single domain antibodies are provided. In some embodiments polypeptides comprising a single domain antibody and a sortase recognition sequence, are provided.
Whitehead Institute For Biomedical Research
03/26/15
20150086560
new patent

Influenza vaccine and therapy


The present invention is directed generally to m1 polypeptides that can be utilized as vaccines and/or antigens for generation of anti-m1 polypeptide antibodies for prophylactic treatment of individuals who are susceptible to infection by influenza virus. The anti-m1 polypeptide antibodies of the invention are useful for treatment of individuals infected with influenza virus, or useful for prophylactic treatment of individuals who are susceptible to infection by influenza virus, or for immune-suppressed individuals who cannot generate an effective antibody response..
Engen Bio Inc.
03/26/15
20150086556
new patent

Anti-activin a antibodies and uses thereof


The disclosure provides compositions and methods relating to or derived from anti-activin a binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin a antibodies that bind human activin a, activin a-binding fragments and derivatives of such antibodies, and activin a-binding polypeptides comprising such fragments.
Amgen Inc.
03/26/15
20150086553
new patent

Polypeptide binding to annexin a1 and use thereof


A polypeptide binding to annexin a1, an antagonist against annexin a1 including the polypeptide, an anti-annexin a1 antibody including the polypeptide or an antigen-binding fragment thereof, and methods of preventing, treating and/or diagnosing a disease, including administering the antagonist and/or the antibody or an antigen-binding fragment thereof to a subject.. .
Samsung Electronics Co., Ltd.
03/26/15
20150086525
new patent

Prebiotic composition or pharmaceutical composition synthesized from catalytic domains producing highly alpha-1,2 branched dextran


The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with .alpha.(1.fwdarw.2) sidechains, comprising at least one region for bonding to glucan and a catalytically active region situated beyond the region bonding to glucan. The invention further relates to polynucleotides coding for said enzymes and vectors containing the same..
Institut National Des Sciences Appliquees (insa)
03/26/15
20150086515
new patent

Imaging-aided gene therapy using mesenchymal stem cells as target-delivery vehicle


Compositions and methods of use thereof encompass engineered mesenchymal stem cells as a vehicle to deliver secreted tissue necrosis factor-rgd4c fusion polypeptides for tumor treatment, thereby reducing side effects of tnf. A reporter gene can be included in vector constructs to monitor the localization and viability of engineered mscs after administration into a recipient animal.
The Board Of Trustees Of The Leland Stanford Junior University
03/26/15
20150086508
new patent

Compositions and methods for enhancing epidermal repair and cutaneous innate immunity


The invention disclosed herein relates to the field of epidermal repair and skin innate immunity. More particularly, the invention concerns the use of a mix of cytokines to inhibit keratinocyte differentiation, activate skin innate immunity, increase the expression of anti-microbial peptides, and improve epidermal repair.
03/26/15
20150086506
new patent

Alteration of cell membrane for new functions


Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene therapy, without the introduction of exogenous dna. Dna sequences, the proteins and polypeptides embodying these sequences are disclosed for modulating the immune system.
University Of Louisville Research Foundation, Inc.
03/26/15
20150086482
new patent

Dye conjugated peptides for fluorescent imaging


The present application discloses compositions and methods of use of peptide targetable constructs for detection, diagnosis and/or imaging of cancer. In preferred embodiments, the targetable construct comprises at least one hapten, at least one fluorescent probe, a chelating moiety and a group iiia metal-18f complex attached to the chelating moiety.
Immunomedics, Inc.


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