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Peptide

Peptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Identification of the presence of specific polypeptides by liquid chromatography and mass spectrometry
Genysis Lab Inc.
January 11, 2018 - N°20180011107

Disclosed are methods for determining the presence of one or more proteins in a sample, the methods comprising: enzymatically digesting the sample with a protease activity to generate a plurality of proteolytic peptides; separating the plurality of proteolytic peptides using liquid chromatography; performing mass spectrometry on the separated plurality of peptides; and wherein a protein is present in the sample ...
Hcv ns4a/modified ns3 polypeptides and uses thereof
Grifols Worldwide Operations Limited
January 11, 2018 - N°20180011096

Modified hepatitis c virus polypeptides are described. The polypeptides include the hcv ns4a domain and modified ns3 domain. The polypeptides retain conformational epitopes. Hcv immunoassays including the polypeptides are also described.
Assessing retinal pigment epithelial cell populations
Cell Cure Neurosciences Ltd.
January 11, 2018 - N°20180011092

A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (pmel17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (cralbp), lecithin retinol acyltransferase (lrat) and sex determining region y-box 9 (sox 9) in the population of cells.
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Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions
The Regents Of The University Of California
January 11, 2018 - N°20180010148

In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, ...
Methods for altering polypeptide expression
The Trustees Of Columbia University In The City Of New York
January 11, 2018 - N°20180010136

The invention is directed to methods and metric suitable for use in modulating the expression of a polypeptide encoded by a nucleic acid sequence. In certain aspects, the invention also relates to methods for introducing modifications in a polypeptide, for example through substitution of one or more nucleic acids in an untranslated sequence or in a coding sequence of a ...
Methods of identifying and validating affinity reagents
Axiomx, Inc.
January 11, 2018 - N°20180010118

The invention features methods of identifying and validating affinity reagents, such as antibodies. The methods of the invention generally involve screening an antibody library by, for example, phage display on bacteria (e. G., e. Coli) to identify particular antibody clones capable of binding a desired target polypeptide. Clones identified in this way can then be validated using yeast 2-hybrid. In ...
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Peptide Patent Applications
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For professional research & prior art discovery
inventor
  • 265+ full patent PDF documents of Peptide-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Novozymes, Inc.
January 11, 2018 - N°20180010112

The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Polypeptide fragments comprising endonuclease activity and their use
Centre National De La Recherche Scientifique
January 11, 2018 - N°20180010109

The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the pa subunit of a viral rna-dependent rna polymerase or variants thereof possessing endonuclease activity, wherein said pa subunit is from a virus belonging to the orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide ...
Herbicide-resistant rice plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use
Instituto Nacional De Tecnologia Agropecuaria
January 11, 2018 - N°20180010101

Herbicide-resistant rice plants, isolated polynucleotides that encode herbicide resistant and wild-type acetohydroxy-acid synthase large subunit 1 (ahasl1) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described. Methods of using the polynucleotides to enhance the resistance ...
Biocatalysts for the preparation of hydroxy substituted carbamates
Codexis, Inc.
January 11, 2018 - N°20180010100

The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.
Hydrogel comprising a scaffold macromer crosslinked with a peptide and a recognition motif
Massachusetts Institute Of Technology
January 11, 2018 - N°20180010091

Methods of forming, dissolving, and functionalizing an extracellular matrix gel on demand based on cross-linking, modification, and dissolution of hydrogels using transpeptidase (e. G. Sortase) are disclosed. Also provided are hydrogels comprising one or more macromers crosslinked to a mixture of peptides, wherein all or a portion of the peptides in the mixture comprise a recognition motif cleavable by a ...
Methods for the treatment of disease using immunoglobulins having fc regions with altered affinities for ...
Macrogenics, Inc.
January 11, 2018 - N°20180009902

The present invention relates to methods of treating or preventing cancer and other diseases using molecules, particularly polypeptides, more particularly immunoglobulins (e. G., antibodies), comprising a variant fc region, wherein said variant fc region comprises at least one amino acid modification relative to a wild-type fc region, which variant fc region binds an fcγr that activates a ...
Anti-ror1 antibodies
Eureka Therapeutics, Inc.
January 11, 2018 - N°20180009892

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for receptor tyrosine kinase-like orphan receptors (ror), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and ...
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Peptide Patent Applications
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For professional research & prior art discovery
inventor
  • 265+ full patent PDF documents of Peptide-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders
Technophage, InvestigaÇÃo E Desenvolvimento Em Biotecnologia, S.a.
January 11, 2018 - N°20180009883

The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the ...
Polypeptides
Vhsquared Limited
January 11, 2018 - N°20180009881

There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain comprising three complementarity determining regions (cdr1-cdr3) and four framework regions, wherein: (a) at least one lysine residue in cdr1, cdr2 and/or cdr3 has been substituted with at least one histidine residue, and/or (b) at least one arginine residue in cdr1, cdr2 and/or cdr3 ...
Multistep final filtration
Hoffmann-la Roche Inc.
January 11, 2018 - N°20180009878

Herein is reported a method for the final filtration of concentrated polypeptide solutions comprising the combination of two immediately consecutive filtration steps with a first filter of 3. 0 μm and 0. 8 μm pore size and a second filter of 0. 45 μm and 0. 22 μm pore size.
Glucagon-receptor selective polypeptides and methods of use thereof
Intarcia Therapeutics Inc.
January 11, 2018 - N°20180009871

This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of ...
Fusion protein comprising leptin and methods for producing and using the same
Askgene Pharma, Inc.
January 11, 2018 - N°20180009869

The present invention provides fusion proteins comprising leptin and a second protein. The presence of the second protein provides increased biological activity and/or increased half-life in vivo. The present invention also provides human, canine and feline leptin molecules fused to peptides, antibodies or antibody fragments which enhances the abilities of the leptin molecules to transport through the blood-brain-barrier (bbb). ...
Mutant chicken interleukin-1beta protein as chicken interleukin-1beta antagonist and uses thereof
National Tsing Hua University
January 11, 2018 - N°20180009867

The present invention provides a mutant chicken interleukin-1β protein as a chicken interleukin-1β antagonist, which has a substituted peptide at position 117 and/or 118 of wild-type chicken interleukin-1β peptides. The mutant chicken interleukin-1β protein is created by using point mutation in a method genetic engineering; it can significantly inhibit proliferation of avian virus, ...
Bmp-2 peptides and methods of use
Lifenet Health
January 11, 2018 - N°20180009865

The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.
Synthetic promoters for high throughput screening and gene modulation
The Regents Of The University Of California
January 11, 2018 - N°20180009864

The present invention provides nucleic acid constructs, expression vectors, transgenic cell and methods of making and using the same, wherein the nucleic acid construct includes a synthetic promoter designed from the endogenous promoter of birc5 and lamc2. In illustrative working embodiments of the invention, an exogenous nucleic acid fragment encoding thymidine kinase is operably linked to the synthetic promoter which ...
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