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Peptide

Peptide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods for mass spectrometry of mixtures of protein or polypeptides using proton transfer reaction
Thermo Finnigan Llc
April 12, 2018 - N°20180102243

A method comprises: (1) making an extract of a biological sample; (2) repeatedly: (a) choosing a respective one of a plurality of pre-determined protein or polypeptide analyte compounds; (b) introducing a portion of the extract into an electrospray ionization source, thereby generating positive ions comprising a plurality of ion species; (c) isolating a plurality of subsets of the ion species comprising respective ...
Dna methylation markers for metastatic prostate cancer
The Johns Hopkins University
April 12, 2018 - N°20180100196

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (tm) and allele-specific methylation (asm) alternation, this method, ...
Nucleic acid construct
Ucl Business Plc
April 12, 2018 - N°20180100163

The present invention provides a nucleic acid construct comprising the following structure: a-x-b in which a and b are nucleic acid sequences encoding a first and a second polypeptide of interest (poi); and x is a nucleic acid sequence which encodes a cleavage site, wherein either the first or second poi is a transmembrane protein which comprises an intracellular retention ...
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  • 265+ full patent PDF documents of Peptide-related inventions.
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S. pyogenes cas9 mutant genes and polypeptides encoded by same
Integrated Dna Technologies, Inc.
April 12, 2018 - N°20180100148

This invention pertains to mutant cas9 nucleic acids and proteins for use in crispr/cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant cas9 protein, wherein the isolated mutant cas9 protein is active in a crispr/cas endonuclease system, wherein the crispr/cas endonuclease system displays reduced off-target editing activity and maintained ...
Prostate-specific membrane antigen binding proteins and related compositions and methods
Aptevo Research And Development Llc
April 12, 2018 - N°20180100021

The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (psma) and are useful for the treatment of prostate cancer (e. G., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (bph). In one embodiment, the multi-specific poly-peptide therapeutics bind both psma-expressing cells and the t-cell receptor complex on t cells to ...
Antibodies to il-6 and use thereof
Alderbio Holdings Llc
April 12, 2018 - N°20180100013

The present invention is directed to antibodies and fragments thereof having binding specificity for il-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the vh, vl and cdr polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-il-6 antibodies and binding fragments thereof conjugated ...
Peptide Patent Pack
Download 265+ patent application PDFs
Peptide Patent Applications
Download 265+ Peptide-related PDFs
For professional research & prior art discovery
inventor
  • 265+ full patent PDF documents of Peptide-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Fc containing polypeptides with altered glycosylation and reduced effector function
Genzyme Corporation
April 12, 2018 - N°20180100010

Provided are binding polypeptides (e. G., antibodies), and drug conjugates thereof, comprising an fc domain with an altered glycosylation profile and reduced effector function. In particular embodiment, the fc domain comprises: an asparagine residue at amino acid position 298, according to eu numbering; and a serine or threonine residue at amino acid position 300, according to eu numbering. Also provided are nucleic ...
Polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin a
Vhsquared Limited
April 12, 2018 - N°20180100009

There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin a.
Polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin b
Vhsquared Limited
April 12, 2018 - N°20180100008

There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin b.
Method for the expression of polypeptides using modified nucleic acids
Hoffmann-la Roche Inc.
April 12, 2018 - N°20180100006

Herein is reported a method for recombinantly producing a polypeptide in a cell comprising the step of cultivating a cell which comprises a nucleic acid encoding the polypeptide, and recovering the polypeptide from the cell or the cultivation medium, wherein each of the amino acid residues of the polypeptide is encoded by at least one codon, whereby the different codons ...
Novel peptides and combination of peptides for use in immunotherapy against various tumors
Immatics Biotechnologies Gmbh
April 12, 2018 - N°20180100005

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Hepcidin analogues and uses thereof
Protagonist Therapeutics, Inc.
April 12, 2018 - N°20180100004

The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and ...
Bifunctional stapled polypeptides and uses thereof
President And Fellows Of Harvard College
April 12, 2018 - N°20180100001

The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e. G., proteins). Certain aspects relate to bifunctional stapled or stiched peptides that bind to an effector biomolecule through the effector domain and ...
Peptide Patent Pack
Download 265+ patent application PDFs
Peptide Patent Applications
Download 265+ Peptide-related PDFs
For professional research & prior art discovery
inventor
  • 265+ full patent PDF documents of Peptide-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Novel a4b7 thioether peptide dimer antagonists
Protagonist Therapeutics, Inc.
April 12, 2018 - N°20180099995

The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of α4β7 to the mucosal addressing cell adhesion molecule (madcam) in vivo.
Nucleic acid construct
Ucl Business Plc
April 12, 2018 - N°20180099994

The present invention provides a nucleic acid construct comprising the following structure: a-x—b in which a is nucleic acid sequence encoding a first polypeptide which comprises a first signal peptide; b is nucleic acid sequence encoding a second polypeptide which comprises a second signal peptide and x is a nucleic acid sequence which encodes a cleavage site, wherein ...
Short synthetic peptide for treating diseases and/or conditions related to angiogenesis
Mackay Memorial Hospital
April 12, 2018 - N°20180099993

Disclosed herein are synthetic peptides and compositions comprising the same, for the treatment and/or prophylaxis of a disease or a condition related to angiogenesis. Also disclosed herein are methods of treating and/or preventing a disease or a condition related to angiogenesis, by administering to a subject in need of such treatment a composition containing a therapeutically effective amount ...
Nanoplatforms for arginase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase detection by posttranslational modification
Kansas State University Research Foundation
April 12, 2018 - N°20180099057

A nanoplatform assembly for detection of arginase, indoleamine 2,3-dioxygenase 1, and/or tryptophan 2,3-dioxygenase. The nanoplatform comprises an oligopeptide, which is used as a linker between two particles. More preferably, the linker is comprised of an oligopeptide containing a substrate for the target enzyme, where the substrate is chemically or physically modified by the target enzyme (but not cleaved). A central ...
Chimeric peptides against htlv-1
April 12, 2018 - N°20180099042

A method of immunizing against htlv-1 is disclosed. The method may include preparing a dna sequence corresponding to a chimeric peptide which may have immunogenic epitopes of htlv-1. These epitopes can include a tax epitope, a gp21 epitope, a gp46 epitope, and/or a gag epitope. The method also includes production of the chimeric peptide using the dna sequence and ...
Therapeutic compositions and methods for treating hiv including identification and manipulation of particular domains associated ...
The Regents Of The University Of California
April 12, 2018 - N°20180099041

Selection of hiv vaccine antigens by use of intrapatient sequence variation to identify mutations in the hiv envelope glycoprotein that affect the binding of broadly neutralizing antibodies and polypeptides identified by these methods.
Novel mhc-independent tumor-associated antigens
Universitaet Duisburg-essen
April 12, 2018 - N°20180099033

The present invention relates to novel tumor-associated antigens, which elicit independently from a presentation via mhc a cd8-positive t-cell response. Gm-csf-receptor alpha chain (csf2ra) and tyrosinase-related protein 2 (trp-2) were found to be targets of cd8-positive t-cell clones which could detect the proteins on the surface of hla i negative melanoma cells. Thus, the invention provides proteins, protein ...
Vaccine compositions and methods of use thereof
University Of Miami
April 12, 2018 - N°20180099032

Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e. G., monoclonal antibody) production, and for the effective delivery of peptides, proteins, sirna, rna or dna to papcs or mhc class ii positive cells (e. G. Tumor cells). Antigens may be, for example, dna that results ...
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