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 Amino acid sequence analyzing method and system patent thumbnailnew patent Amino acid sequence analyzing method and system
peptide-fragment mixtures obtained by fragmenting a sample with each of multiple enzymes which cause cleavage at different sites are subjected to mass spectrometry. De novo sequencing is performed on the obtained results to deduce partial sequence candidates for various kinds of fragments (s1 and s2).
Shimadzu Corporation


 Method for measurement of hba1c using amadoriase that reacts with glycated peptide patent thumbnailnew patent Method for measurement of hba1c using amadoriase that reacts with glycated peptide
This invention provides an amadoriase that can react with a wide variety of glycated peptides generated upon hydrolysis of the β chain of hemoglobin alc (hbalc) to generate hydrogen peroxide, a method for measurement of hbalc using such amadoriase, and a reagent kit for measurement of hbalc using such amadoriase. Provided is an amadoriase obtained by substitution of one or more amino acids at positions corresponding to amino acids selected from the group consisting of amino acids 62, 63, 102, 106, 110, 113, and 355 in the amino acid sequence of the amadoriase derived from the genus coniochaeta or the like which amadoriase is capable of oxidizing a wide variety of glycated peptides to generate hydrogen peroxide.
Kikkoman Corporation


 Biomarkers to improve prediction of heart failure risk patent thumbnailnew patent Biomarkers to improve prediction of heart failure risk
The present disclosure relates to the field of laboratory diagnostics. Specifically, methods are disclosed for determining a patient's risk of suffering from heart failure (hf) based on the detection of nt-probnp, troponin t, and/or a natriuretic peptide.

 Multiplex mrm assay for evaluation of cancer patent thumbnailnew patent Multiplex mrm assay for evaluation of cancer
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (er), progesterone receptor (pr), and/or antigen ki67 (ki67) proteins that are particularly advantageous for quantifying the er, pr, and/or ki67 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


 Method for biomarker and drug-target discovery for prostate cancer diagnosis and treatment as well as biomarker assays determined therewith patent thumbnailnew patent Method for biomarker and drug-target discovery for prostate cancer diagnosis and treatment as well as biomarker assays determined therewith
The invention relates to biomarker assays based on protein/peptide biomarkers which show a pronounced differential behaviour between healthy and cancerous sample proteomes e.g. By mass spectrometric measurement and/or antibody-based assays such as an enzyme-linked immunosorbent assay (elisa) determination of the protein biomarkers in serum, plasma or blood itself..
Kantonsspital St. Gallen


 Zwitterionic reagents patent thumbnailnew patent Zwitterionic reagents
Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility.
Siemens Healthcare Diagnostics Inc.


 Quantitative controls and calibrators for cellular analytes patent thumbnailnew patent Quantitative controls and calibrators for cellular analytes
A method and apparatus that serve as a control and calibrator for assays performed on cells and tissues mounted on a microscope slide is described. The apparatus comprises a quality control moiety, such as a peptide epitope, linked to a particulate object, such as a clear spherical bead and the bead is preferably approximately the size of a cell.
Medical Discovery Partners Llc


 In situ hybridization detection method patent thumbnailnew patent In situ hybridization detection method
The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ish) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target.
Dako Denmark A/s


 Peptide nucleic acid probe, kit and  the detection and/or quantification of esherichia coli o157:h7 and applications thereof patent thumbnailnew patent Peptide nucleic acid probe, kit and the detection and/or quantification of esherichia coli o157:h7 and applications thereof
The present invention also includes the development of the kit of detection and respective procedure for the specific identification of escherichia coli o157:h7 using the above referred sample types.. .

 Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same patent thumbnailnew patent Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
Ikeda Food Research Co., Ltd.


new patent

Method of producing fr901228


Depsipeptides and congeners thereof are disclosed having structure (i), wherein m, n, p, q, x, r1, r2 and r3 are as defined herein. These compounds, including fr901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant.
Astellas Pharma Inc.


new patent

Enone reductases


The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations..
Codexis, Inc.


new patent

Use of meganucelases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof


A single chain homing endonuclease, comprising a first variant of i-crei having the amino acid sequence of accession number pdb 1g9y and a second variant of i-crei variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide.. .
Cellectis S.a.


new patent

Manipulation of plasmodesmal connectivity to improve plant yield and fitness


Plants are provided that express a modified plasmodesmata localized protein 5 (pdlp5). The modified pdlp5 protein may modify plasmodesmal connectivity.
University Of Delaware


new patent

Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement


Recombinant polynucleotides and recombinant polypeptides useful for improvement of plants are provided. The disclosed recombinant polynucleotides and recombinant polypeptides find use in production of transgenic plants to produce plants having improved properties..
Monsanto Technology Llc


new patent

Resource use efficiency improvement in plants


Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased yield, increased resource use efficiency, increased water use efficiency, increased light use efficiency, increased photosynthetic capacity, increased photosynthetic rate, increased photosynthetic resource use efficiency, greater vigor, and/or greater biomass as compared to a control plant..
Mendel Biotechnology, Inc.


new patent

Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics


Provided are isolated polypeptides which are at least 80% homologous to seq id nos: 710-1153 and 9276-15726, isolated polynucleotides which are at least 80% identical to seq id nos: 1-709 and 1157-9275, nucleic acid constructs comprising same, transgenic cells expressing same, transgenic plants expressing same and method of using same for increasing yield, abiotic stress tolerance, growth rate, biomass, vigor, oil content, photosynthetic capacity, seed yield, fiber yield, fiber quality, fiber length, and/or nitrogen use efficiency of a plant.. .
Evogene Ltd.


new patent

Compositions and methods for differential regulation of fatty acid unsaturation in membrane lipids and seed oil


Aspects of the invention provide methods for differential regulation of fatty acid unsaturation in seed oil and membrane lipids of plants based on modulation of a previously unknown biosynthetic pathway involving a novel phosphatidylcholine:diacylglycerol cholinephosphotransferase (pdct) that regulates phosphatidylcholine biosynthesis in developing oil seed plants. Specific aspects relate to inventive pdct polypeptides including, for example, variants, deletions, muteins, fusion proteins, and orthologs thereof (collectively pdct proteins), to nucleic acids encoding same, to plants comprising such pdct sequences or proteins or devoid or depleted of such pdct proteins or sequences, and to methods for generating plants having altered or no pdct expression and/or activity, including but not limited to methods comprising mutagenesis, recombinant dna, transgenics, etc..
Washington State University


new patent

Tobacco enzymes for regulating content of plant metabolites, and use thereof


The present invention provides a polynucleotide having a function of regulating a content of a plant metabolite, a polypeptide having a function of regulating a content of a plant metabolite, a vector containing the polynucleotide or a part of the polynucleotide, and a transformed plant produced by using the vector. Examples of such polynucleotides or polypeptides include polynucleotides or polypeptides with homology with quinolinate synthase or those which are predicted to be transcription factors.
Japan Tobacco Inc.


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new patent

Compositions and methods containing a constitutive promoter to modify the expression of genes of interest in plants


The present invention relates to a new promoter of the expression of genes in plants. More specifically, the invention relates to regulatory sequences of polynucleotides that are isolated from soy plants and can initiate and activate polynucleotide transcription, and to the use of these regulatory sequences to modify the transcription of endogenous and/or heterologous polynucleotides and to produce polypeptides.
Empresa Brasileira De Pesquisa Agropecuária - Embrapa


new patent

Method for producing peptide library, peptide library, and screening method


An object of the present invention is to provide a method for producing a peptide library capable of incorporating an arbitrary number of arbitrary proteinogenic and/or non-proteinogenic amino acids in an arbitrary site. The invention provides a method for producing a peptide library including 1×106 or more kinds of peptides containing amino acids encoded by n1n2n3, including a step of preparing an mrna library including mrnas which encode peptides of the peptide library and each contain at least one n1n2n3; and a step of translating each mrna of the mrna library in a cell-free translation system added with trna containing an anticodon to any one of n1n2n3 codons and charged with an amino acid corresponding to the codon (wherein, n1, n2, and n3 are each independently selected from adenine (a), guanine (g), cytosine (c), and uracil (u) and an arbitrary amino acid is reassigned to each n1n2n3)..
Peptidream Inc.


new patent

Acyltransferases and uses thereof in fatty acid production


The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides.
Basf Plant Science Company Gmbh


new patent

Polypeptide composition and culture pluripotent stem cell using same


A polypeptide composition induces a pluripotent stem cell culturing property, particularly, an excellent cell growth ability. The polypeptide composition contains a predetermined polypeptide including an amino acid sequence of human vitronectin or an amino acid sequence of a predetermined first region derived from human vitronectin.
Fujifilm Corporation


new patent

Ntrk2 fusions


The invention provides to ntrk (“neurotrophic tyrosine receptor kinase) gene fusions, ntrk. Fusion proteins, and fragments of those genes and polypeptides.
Blueprint Medicines Corporation


new patent

Antibodies and fragments thereof raised against the alpha-3 domain of hla-g protein, methods and means for their preparation, and uses thereof


An antibody or antigen-binding fragment thereof which specifically binds the α3 domain of a hla-g protein, in particular binds the β2-microglobulin free hla-g protein exhibiting an α3 domain. The nucleic acid molecules encoding a human hla-g α3 domain polypeptide, which is selected from a group of specific sequences, and vectors for the cloning and/or expression of such nucleic acid molecules, recombined cells or cell lines and compositions for use in a host in need thereof to interfere with and neutralize the immune down-regulation due to hla-g proteins, and/or improving or treating conditions showing hla-g+ lesions, and/or improving or treating a neoplasic condition or disease.
Invectys


new patent

Smart car devices, de car polypeptides, side cars and uses thereof


The present invention relates generally to the field of rna control devices and/or destabilizing elements (de) combined with chimeric antigen receptors (cars) in eukaryotic cells. The present invention also relates to split cars (side-cars) in eukaryotic cells.
Chimera Bioengineering, Inc.


new patent

Chemokine receptor binding polypeptides


The present invention relates to polypeptides directed against or specifically binding to chemokine receptor cxcr2 and in particular to polypeptides capable of modulating signal transduction from cxcr2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of cxcr2..
Novartis Ag


new patent

Anti-pd-l1 monoclonal antibodies and fragments thereof


The present invention is based, in part, on the discovery of monoclonal antibodies that specifically bind to the cytoplasmic domain of pd-l1 antibodies useful for diagnostic, prognostic, and therapeutic applications, as well as immunoglobulins polypeptides, and nucleic acids thereof.. .
Dana-farber Cancer Institute Inc.


new patent

Vstm5 antibodies, and uses thereof for treatment of cancer, infectious diseases and immune related diseases


The present invention relates to vstm5-specific antibodies, antibody fragments, and vstm5 polypeptides, conjugates and compositions comprising same, for modulating (antagonizing or agonizing) one or more of the effects of vstm5 expression on immunity. More specifically, the present invention relates to vstm5-specific antibodies, antibody fragments, and vstm5 polypeptides, conjugates and compositions comprising same for treating and aiding in the diagnosis of cancer, infectious diseases and immune related diseases, e.g., those associated with aberrant (higher or lower than normal) vstm5 expression by diseased and/or immune cells and/or aberrant (increased or reduced) vstm5-mediated effects on immunity..
Compugen Ltd.


new patent

Cdca1 epitope peptides and vaccines containing the same


peptide vaccines against cancer are described herein. In particular, the present invention describes epitope peptides derived from cdca1 that elicit ctls.
Oncotherapy Science, Inc.


new patent

Compositions and methods for treating conditions associated with y-herpesviruses


One object of certain embodiments of the present invention is therapeutic agents and compositions to treat conditions associated with activation of yhv. In certain embodiments, the therapeutic agent is a synthetic peptide that preferentially binds to a viral bcl-2 homolog over a cellular bcl-2 homolog.
Ndsu Research Foundation


new patent

Yap protein inhibiting polypeptide and application thereof


Provided in the present invention are a yap protein inhibiting polypeptide and application thereof. In particular, the present invention obtains a key binding site of yap protein and tead, screens a polypeptide with best yap inhibitory activity and modifies the polypeptide, such as adding a disulfide linkage, replacing an amino acid, removing and/or adding (for example, adding a cell-penetrating element), and finally screens and verifies the obtaining of a series of polypeptides with yap protein activity inhibiting effect and good stability.
Bao Kang Biomedical Healthcare Inc


new patent

Streptavidin muteins and methods of using them


The invention concerns novel streptavidin muteins. In one embodiment such a mutein (a) contains at least one mutation in the region of the amino acid positions 115 to 121 with reference to the amino acid sequence of wild type streptavidin as set forth at seq id no: 15 and (b) has a higher binding affinity than each of (i) a streptavidin mutein that comprises the amino acid sequence val44-thr45-ala46-arg47 (seq id no: 98), or (ii) a streptavidin mutein that comprises the amino acid sequence he44-gly45-ala46-arg47 (seq id no: 99) at amino acid positions 44 to 47, or (iii) wild type-streptavidin (seq id no: 15) for peptide ligands comprising the amino acid sequence trp-ser-his-pro-gln-phe-glu-lys (seq id no: 100)..
Iba Gmbh


new patent

Novel amylin and calcitonin receptor agonist


The present invention relates to peptides comprising an amino acid sequence seq id no: 1 (easelstaalgrlsaelhelatlprtetgpesp), analogues and derivatives thereof and pharmaceutical compositions comprising such peptides and derivatives. This invention further regards the use of these peptides according to seq id no: 1, analogues and derivatives thereof as medicaments..
Novo Nordisk A/s


new patent

Glycopeptide antibiotic analogs effective against vancomycin-resistant bacterial strains


The invention is directed to glycopeptide antibiotics and their aglycones that are engineered to overcome bacterial resistance by replacement of a single, specific peptide carboxamide group in the core peptide of the glycopeptide antibiotic with an amidine group. The amidine pseudopeptide analog of the glycopeptide is effective in killing vancomycin-resistant bacteria at therapeutically achievable concentrations in a patient.
The Scripps Research Institute


new patent

Immunomodulators


The present disclosure provides novel macrocyclic peptides which inhibit the pd-1/pd-l1 and pd-l1/cd80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.. .
Bristol-myers Squibb Company


new patent

Wnt family-derived peptides and use thereof


The present invention relates to a wnt-derived novel peptide and use thereof. Wnt-derived peptide of the present invention possesses identical or similar activities to natural-occurring wnt protein, and has much higher stability and skin penetration potency than natural-occurring wnt protein.
Caregen Co., Ltd.


new patent

Inhibition of pulmonary fibrosis with nutlin-3a and peptides


In fibrotic lung fibroblasts, basal levels of p53 protein (and mir-34a) are markedly suppressed, leading to reduced p53-mediated inhibition of upa and upar, or concurrent induction of pai-1. These changes contribute to excessive fl-fibroblast proliferation and production of extracellular matrix (ecm), and, therefore, pulmonary fibrosis.
Board Of Regents, The University Of Texas System


new patent

Photolabile linker for the solid-phase synthesis of hydrazides and pyranopyrazoles


The photolabile hydrazine linker of the present invention is based on the o-nitro-veratryl group, which is capable of releasing hydrazide derivatives upon uv irradiation. The linker allows for a new solid-phase peptide synthesis (spps) strategy which is fully orthogonal to the most commonly used protecting groups and chemical methods in spps and shows excellent compatibility with peptide composition, notably the 20 naturally occurring a-amino acid residues (even in their side-chain protected form) are accepted in the c-terminal of the peptide hydrazides.
Danmarks Tekniske Universitet


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new patent

Novel reagents for universal site-specific labeling and modifications of nucleic acids


The present invention discloses a method of harnessing versatile phosphoramidation reactions to regioselectively incorporate alkynyl/azido groups into post-synthetic nucleic acids primed with phosphate at the 5′ termini. With and without the presence of copper, the modified nucleic acids were subjected to azide-alkyne cycloaddition to obtain various nucleic acid conjugates including a peptide-oligonucleotide conjugate (poc) with a high yield..
Kaohsiung Medical University


new patent

Compounds and methods for the enhanced degradation of targeted proteins


The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a vhl ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein.
Yale University


new patent

Phenylcarbamate derivatives as formyl peptide receptor modulators


The present invention relates to n-phenyl carbamate derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the n-formyl peptide 2 receptor.. .
Allergan, Inc.


new patent

Catalytic hydrogenation for producing amines from carboxylic acid amides, carboxylic acid diamides, di-, tri-, or polypeptides, or peptide amides


The present invention relates to a process for the preparation of amines, comprising the following steps: a. Reaction of a (i) carboxylic acid amide of the general formula (i), or (ii) carboxylic acid diamide of the general formula (ii), or (iii) di-, tri- or polypeptide, or (iv) peptide amide with carboxy-terminal amide function with an alkylating agent, b.
Evonik Degussa Gmbh


new patent

Combination therapies for the treatment of alzheimer's disease and related disorders


The present invention relates to combination therapies for treating alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits ab peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with tau or alpha-synuclein; or regulates amyloid peptide washout..
The General Hospital Corporation


new patent

Peptidic nanodelivery composition targeting two receptors


A polypeptide conjugate for use in a method for binding and/or internalization of the polypeptide conjugate to a mammalian cell having a transferrin receptor (tfrc) and/or receptor for advanced glycation end products (rage). The polypeptide conjugate may be used in a method for targeting of a drug delivery system or diagnostic delivery system..

new patent

Insulin-like growth factor mimetics for use in therapy


This relates to the use of an igf-1 mimetic in human therapy. In particular, disclosed herein is the use of an igf-1 precursor protein, particularly a human igf-1 precursor protein, comprising the e-peptide for the treatment of spinal and bulbar muscular atrophy (sbma) in a patient suffering from said disease..
National Institutes Of Health


new patent

Acylated glucagon analogues


The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral ph, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity..
Novo Nordisk A/s


new patent

Hydrogels formed from polypeptide micelles and methods of use thereof


The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand..
Duke University


new patent

Dual peptide-mediated targeted delivery system


This invention is generally related to a dual-peptide delivery system, where one peptide exhibits a receptor-targeting moiety and the other peptide exhibits an endosome-disruptive bioactivity.. .
Clemson University


new patent

Subunit vaccine platform based on multimeric ribonucleoproteins comprising nucleoproteins of a non-segmented negative-strand rna virus as carriers of heterologous polypeptides


The present invention relates to a subunit vaccine platform based on multimeric ribonucleoproteins (rnps) comprising nucleoproteins of a non- segmented negative-strand ribonucleic acid (rna) virus as carriers of heterologous polypeptides. The present invention also relates to multimeric rnps resulting from the assembly of at least 200 fusion proteins with a cellular rna, or to recombinant yeasts or yeast lysates expressing these multimeric rnps.
Universite Paris Diderot - Paris 7


new patent

Methods of reducing corneal endothelial cell loss


Provided herein are methods of reducing corneal endothelial cell loss (e.g., nerve loss-related corneal endothelial cell loss) that include selecting a subject identified as having an eye with reduced numbers of corneal nerves as compared to a reference eye, e.g., an eye of a healthy control, and administering vasoactive intestinal peptide (vip) or a nucleic acid encoding vip to the selected subject.. .
Schepens Eye Research Institute


new patent

Compositions and methods for using and identifying antimicrobial agents


As disclosed herein methods are provided to identify compounds with antimicrobial activity, and methods for treating subjects by administering the compounds. In particular, the invention provides methods for treating and/or preventing microbial diseases and infections.
University Of Virginia Patent Foundation


new patent

Modulators of syndecan-2 and uses thereof


Modulators of syndecan-2, such as an antibody to syndecan-2 that cross-links syndecan-2 on the cell surface or a syndiecan-2 polypeptide that interferes with syndecan-2 receptor binding, is used to regulate a th17 mediated disease such as an autoimmune disease, fibrosis or cancer.. .
Orbsen Therapeutics Limited


new patent

N-acyldipeptide derivatives and their uses


N-acyldipeptide derivatives are described. Compositions comprising the n-acyldipeptide derivatives are therapeutically effective for treating disorders and condition associated with the nervous system or musculoskeletal system, such as pain, weakness, numbness, arthritis, joint inflammation, weakness of muscles or joints, and myopia..

new patent

Nanoparticle-containing hydrogels


There is provided a nanoparticle-containing hydrogel comprising metal nanoparticles and at least one peptide. The nanoparticle-containing hydrogel may possess antibacterial activity.
Agency For Science, Technology And Research


new patent

Combination therapies for the treatment of alzheimer's disease and related disorders


The present invention relates to combination therapies for treating alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits ab peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with tau or alpha-synuclein; or regulates amyloid peptide washout..
The General Hospital Corporation


new patent

Polyethylene glycol-cactus oligopeptide bonding rapamycin derivatives


The present invention provides compounds represented by formula (i) and pharmaceutical acceptable salts thereof, preparation method therefor and pharmaceutical composition containing the compounds represented by formula (i) and pharmaceutical acceptable salts thereof. In the compounds of the present invention, each terminal group of polyethylene glycol molecule can bond with a plurality of rapamycin molecules by cactus oligopeptide, with the loading rate of the pharmaceutical being increased.
Jenkem Technology Co., Ltd.


new patent

Peptides for skin rejuvenation and methods of using the same


The invention provides compositions for stimulating the formation of one or more extracellular matrix components that contain a lipoaminoacid derivative of the tripeptide carnosine such as n-octanoyl carnosine. Also provided are compositions containing n-octanoyl carnosine in combination with selected tripeptide and/or tetrapeptides as well as pharmaceutical and/or cosmetic compositions containing such compositions.
Neocutis Sa


new patent

Combination therapies for the treatment of alzheimer's disease and related disorders


The present invention relates to combination therapies for treating alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits ab peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with tau or alpha-synuclein; or regulates amyloid peptide washout..
The General Hospital Corporation


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new patent

Peptide composition and respective uses


Thus, the present invention aims to provide a composition for treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.. .





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This listing is a sample listing of patent applications related to Peptide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Peptide with additional patents listed. Browse our RSS directory or Search for other possible listings.


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