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Peptide patents



      
           
This page is updated frequently with new Peptide-related patent applications. Subscribe to the Peptide RSS feed to automatically get the update: related Peptide RSS feeds. RSS updates for this page: Peptide RSS RSS


Date/App# patent app List of recent Peptide-related patents
08/14/14
20140230098
 Polypeptides having endoglucanase activity and polynucleotides encoding same patent thumbnailPolypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230097
 Polypeptides having xylanase activity and polynucleotides encoding same patent thumbnailPolypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230096
 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same patent thumbnailPolypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230094
 Yield increase in plants overexpressing the shsrp genes patent thumbnailYield increase in plants overexpressing the shsrp genes
A transgenic crop plant transformed by a serine hydroxymethyltransferase-like stress-related polypeptide (shsrp) coding nucleic acid, wherein expression of the nucleic acid sequence in the crop plant results in the plant's increased root growth, and/or increased yield, and/or increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic crop plants.
08/14/14
20140230081
 Polynucleotide, polypeptide, animal model and method for the development of complement system modulators patent thumbnailPolynucleotide, polypeptide, animal model and method for the development of complement system modulators
The present invention is in the field of molecular biology, more particularly, the present invention relates to nucleic acid sequences and amino acid sequences of a hamster c5ar1 and the use of hamster as an animal model for the characterization of complement system modulators within drug discovery.. .
08/14/14
20140229114
 Genomic/proteomic sequence representation, visualization, comparison and reporting using bioinformatics character set and mapped bioinformatics font patent thumbnailGenomic/proteomic sequence representation, visualization, comparison and reporting using bioinformatics character set and mapped bioinformatics font
Genomic or proteomic data are encoded as a genomic or proteomic character string comprising characters of a bioinformatics character set (20). Each base or peptide of the genomic or proteomic data is represented by a single character of the bioinformatics character set, and each character of the bioinformatics character set encodes (i) a base or peptide and (ii) at least one annotated datum value associated with the base or peptide.
08/14/14
20140228551
 Compositions, methods of synthesis and use of carbohydrate targeted agents patent thumbnailCompositions, methods of synthesis and use of carbohydrate targeted agents
The invention provides d02s derivatives conjugated to monosaccharide ligands directly or through a linker and optionally chelated to a metal, wherein the d02s derivatives having the following structure: wherein r1′, r2′ are each independently —oh or —o-alkyl; r1 is a hydrogen, a linker, or a ligand; r3 is a linker and/or a ligand; and n is an integer from 1 to 10; the linker is an amino acid, a peptide, an amino alcohol, a polyethylylene glycol, an alkyl, an alkenyl, an alkynyl, an azide, an aromatic compound, a carboxylic acid, or an ester, the alkyl, alkenyl, or alkynyl is optionally substituted with an alkyl, a halogen, a nitro group, a hydroxyl group, an amino group, or a carboxyl group; the ligand is a glut1 targeting moiety.. .
08/14/14
20140228548
 Viral clearance methods patent thumbnailViral clearance methods
The invention provides methods for separating a polypeptide of interest (such as an antibody) from a virus. In some embodiments, the methods involve eluting the polypeptide of interest from a protein a resin with an elution buffer have a particular range of conductivity values that minimizes the amount of virus that co-elutes with the polypeptide of interest..
08/14/14
20140228546
 Serum albumin binding proteins patent thumbnailSerum albumin binding proteins
The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.. .
08/14/14
20140228544
 Constructs and libraries comprising antibody surrogate light chain sequences patent thumbnailConstructs and libraries comprising antibody surrogate light chain sequences
The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising vpreb sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same..
08/14/14
20140228542
Method for producing peptide fractions and use thereof
The invention relates to a method for producing enriched peptide fractions from protein-containing raw materials, in which protein hydrolysates are separated using chromatography, according to the physiochemical properties thereof, by means of stationary phases with an aqueous solution as an elution agent.. .
08/14/14
20140228541
Methods and compositions for improved f-18 labeling of proteins, peptides and other molecules
The present application discloses compositions and methods of synthesis and use of 18f- or 19f-labeled molecules of use in pet, spect and/or mr imaging. Preferably, the 18f or 19f is conjugated to a targeting molecule by formation of a complex with a group iiia metal and binding of the complex to a bifunctional chelating agent, which may then be directly or indirectly attached to the targeting molecule.
08/14/14
20140228540
Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
The present invention relates to timp-3 binding compositions, methods of producing such compositions, and methods of using such compositions, including in the treatment of various conditions.. .
08/14/14
20140228312
Antibiotic composition and its uses
The present invention relates to a composition comprising: an antibiotic selected from the group consisting of an aminoglycoside antibiotic, a beta-lactam antibiotic, an ansamycin antibiotic, a macrolide antibiotic, a sulfonamide antibiotic, a quinolone antibiotic, an oxazolidinone antibiotic, a glycopeptide antibiotic, and a mixture thereof; and a fatty acid represented by formula (i), a stereoisomer, a salt or an ester thereof, wherein r1 is a substituted or unsubstituted aliphatic group.. .
08/14/14
20140228296
Diagnosis, prognosis, and treatment of kidney disease
The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin.
08/14/14
20140228295
Inhibitors of beta integrin-g protein alpha subunit binding interactions
Provided herein are compounds that inhibit a binding interaction between a β integrin and a g protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog.
08/14/14
20140228294
Natriuretic polypeptides with unique pharmacologic profiles
This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity.
08/14/14
20140228291
Post procedure skin care gel and methods of use thereof
Compositions and methods are provided for a post-procedure care following the treatment of skin with cosmetic skin resurfacing treatments, which include without limitation a variety of laser treatments, chemical peeling and dermabrasion, by applying a silicone-based gel formulation in combination with therapeutic peptides. Peptides of interest include one or more of transforming growth factor, epidermal growth factor, and basic fibroblast growth factor.
08/14/14
20140228289
Modified and stabilized gdf propeptides and uses thereof
Modified and stabilized propeptides of growth differentiation factor proteins, such as gdf-8 and bone morphogenetic protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial.
08/14/14
20140228288
Pharmaceutical compositions
The present invention provides pharmaceutical compositions comprising at least one polypeptide having glp-1 activity wherein an effective dose of said pharmaceutical composition comprises 15 mg, 30 mg, 50 mg or 100 mg of said polypeptide having glp-1 activity. Also provided are methods of administering the pharmaceutical compositions of the invention..
08/14/14
20140228284
Pharmaceutical compositions
The present invention provides pharmaceutical compositions comprising at least one polypeptide having glp-1 activity wherein an effective dose of said pharmaceutical composition comprises 15 mg, 30 mg, 50 mg or 100 mg of said polypeptide having glp-1 activity. Also provided are methods of administering the pharmaceutical compositions of the invention..
08/14/14
20140228277
Peptide inhibitors of bace1
The invention provides peptide inhibitors of bace1 that bind to the active site in a noncanonical fashion, and methods of use thereof.. .
08/14/14
20140228274
Liquid detergent composition
In a liquid detergent comprising a subtilisin and optionally a second (non-subtilisin) enzyme, the combination of a peptide aldehyde (or hydrosulfite adduct thereof) with a salt of a monovalent cation and a monovalent organic anion has a synergistic stabilizing effect on the subtilisin and/or the second enzyme. The improved enzyme stability is of particular interest in liquid detergent compositions where the enzyme would otherwise have poor storage stability..
08/14/14
20140228249
Detection and assay devices and methods of making and using the same
An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described..
08/14/14
20140228238
Genes and polypeptides relating to breast cancers
The present application provides novel human genes a7322, whose expression is markedly elevated in breast cancer. The present application also provides human genes f3374 whose expression is markedly elevated in breast cancer.
08/14/14
20140227799
Method for measuring anti-wt1 antibody
Provided is an invention relating to a method for measuring an anti-wt1 antibody in a sample allowing measurement and evaluation of the anti-wt1 antibody with higher accuracy and to use of the method. The method for measuring an anti-wt1 antibody in a sample includes using a polypeptide having antigenicity to the anti-wt1 antibody selected from a polypeptide comprising the amino acid sequence of positions 294-449 in seq id no: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides and/or a polypeptide having antigenicity to the anti-wt1 antibody selected from a polypeptide comprising the amino acid sequence of positions 181-324 in seq id no: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides..
08/14/14
20140227788
Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering metabolism in a cell using isolated and/or purified polypeptides and nucleic acid sequences from alicyclobacillus acidocaldarius..
08/14/14
20140227773
Enzymatic cleavage based lateral flow assays
Methods and devices for detecting a target enzyme include an anchored or trapped peptide complex. The peptide complex includes an anchor particle immobilized on a sample analysis device or trapped in a reaction receptacle including a filter, a peptide, with at least one enzyme cleavage site for a target enzyme, bound to the anchor particle, at least one detectable label, and at least one first tag bound to the peptide on a side of the enzyme cleavage site opposite the anchor particle.
08/14/14
20140227765
Compositions and methods related to viruses of the genus negevirus
Certain embodiments are directed to negevirus and their polynucleotides and polypeptides.. .
08/14/14
20140227763
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227761
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227760
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227759
Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use
An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The ogluc variant polypeptide has at least 60% amino acid sequence identity to seq id no: 1 and at least one amino acid substitution at a position corresponding to an amino acid in seq id no: 1.
08/14/14
20140227739
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227738
Polypeptides having protease activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227727
Unconventional protein secretion
The present invention relates to an expression cassette comprising a nucleotide sequence encoding an amino acid sequence, a fragment or variant thereof which directs unconventional protein secretion and a nucleotide sequence encoding a protein of interest. Also contemplated is a vector which comprises the expression cassette, host cells comprising the vectors as well as methods and uses for the production of a polypeptide of interest..
08/14/14
20140227724
Nucleic acid construct for use in screening for peptide antibody, and screening method using same
The present invention provides a novel tool for simply screening a candidate molecule for an antibody and a method for screening a candidate molecule for an antibody using the tool. A nucleic acid construct includes: (x) an encoding nucleic acid of an antibody candidate, obtained by inserting an encoding nucleic acid of any peptide into an encoding nucleic acid of an antibody; (y) an encoding nucleic acid of a peptide tag; and (z) an encoding nucleic acid of an aptamer that is bindable to the peptide tag are used.
08/14/14
20140227708
Methods and kits used in identifying microrna targets
Described herein are methods and kits used to identify an endogenously expressed target mrna of a microrna of interest. The method involves the use of a dominant negative gw182 polypeptide that forms a stable complex with the target mrna.
08/14/14
20140227391
Polypeptides having alpha-glucosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
08/14/14
20140227348
Peptides that target dorsal root ganglion neurons
The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (drg) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example.
08/14/14
20140227346
Immunogenic combination compositions and uses thereof
This invention generally relates to immunogenic compositions that comprise an rna component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in rna-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens..
08/14/14
20140227344
Cell penetrating peptides for intracellular delivery of molecules
The présent invention relates to cell-penetrating peptides characterized in that it comprises an amino acid séquence selected in the group consisting of x1lx2ralwx9lx3x9x4lwx9lx5x6x7x8, x1lx2larwx9lx3x9x4lwx9lx5x6x7x8 and x1lx2arlwx9lx3x9x4lwx9lx5x6x7x8, wherein x1 is beta-a or s, x2 is f or w, x3 is l, w, c or i, x4 is s, a, n or t, xs is l or w, x6 is w or r, x7 is k or r, x8 is a or none, and x9 is r or s. Thèse peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-pentrating peptides around the cargo..
08/14/14
20140227323
Recombinant adenylate cyclase toxin of bordetella induces t cell responses against tumoral antigens
An immunogenic composition comprising a recombinant protein comprising a bordetella cyaa, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided.
08/14/14
20140227313
Group a streptococcal m-related proteins and methods of use
Immunogenic group a streptococcus m-related polypeptides and peptides and immunogenic compositions comprising these m-related polypeptides and peptides are provided herein that evoke cross-opsonic and cross-protective anti-gas and anti-sdse antibodies in animals. Also provided are preparations comprising immunogenic compositions that comprise m-related polypeptides, peptides, or fusion proteins and that further comprise at least one additional group a streptococcus immunogen, such as an m peptide or spa peptide..
08/14/14
20140227312
A1 moiety of cholera toxin a subunit as an adjuvant for mucosal and systemic vaccines
The present invention relates to cholera toxin cta1 protein fragments, adjuvant compositions, and methods relating to adjuvants for vaccines. The invention also relates to using recombinant cta1 fragments conjugated to a polypeptide containing a protein transduction domain or cell-penetrating peptide as an immunomodulator..
08/14/14
20140227308
Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof
The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several hpv antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (cyaa) protein or of a fragment thereof, wherein said cyaa fragment retains the property of said adenylate cyclase protein to target antigen presenting cells. It also concerns polynucleotides encoding the same.
08/14/14
20140227306
Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
The present invention relates to use of multimeric multi-epitope peptide-based compositions for immunizing subjects against influenza by administering the compositions to the subject prior to or together with seasonal or pandemic influenza vaccines. The present invention also relates to compositions that include a multimeric multi-epitope polypeptide and a seasonal or pandemic preparation against influenza..
08/14/14
20140227305
Epstein-barr-virus vaccine
The present invention relates to a vaccine comprising a particle, said particle comprising (i) at least one epstein-barr virus (ebv) structural polypeptide, (ii) at least one ebv lytic polypeptide, (iii) membrane lipids, said particle being devoid of ebv dna, wherein (a) the b-cell transformation capacity of one or more ebv polypeptides required for b-cell transformation as comprised in said particle is disabled while their immunogenicity is maintained; and/or (b) said particle is devoid of one or more ebv polypeptides required for b-cell transformation. Furthermore, the invention relates to a method for generating a particle, to a cell obtained in the method of the invention, a kit comprising the vaccine or the particle generated according to the method of the invention.
08/14/14
20140227303
Methods for diagnosing and monitoring diseases or conditions using disease modified biomolecules and measurement of a functional immune response
Methods and assays for disease prognosis, detection and treatment monitoring are provided. The assays and methods measure functional immune responses to disease modified biomolecules (dmbs) that are characteristic of a disease of interest.
08/14/14
20140227301
Immunogenic compositions against human progastrin peptides
Immunogens against human extended-progastrin species comprise (a) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a n- and/or c-terminal processed species of a progastrin joined to (ii) a 7 amino-acid spacer coupled to (b) an immunogenic carrier. Illustrative of the mimetic peptide/spacer combination are a 21 amino-acid peptide (seq id no.: 1) and other, related polypeptides (seq id nos.: 2-5).
08/14/14
20140227293
Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
The present invention provides methods and compositions for the treatment and prevention of angiogenesis, or cancer, e.g., metastatic cancer by administering an effective amount of an inhibitor of immunoglobulin containing proline rich receptor-1 (igpr-1) protein or expression. In particular, the present invention provides methods and compositions for the treatment and prevention of cancer by administering an effective amount of an inhibitor of immunoglobulin containing proline rich receptor-1 (igpr-1) protein or expression which is a soluble extracellular domain igpr-1.
08/14/14
20140227278
Antibodies to human signal peptide-containing proteins
The invention provides a human signal peptide-containing proteins (sigp) and polynucleotides which identify and encode sigp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/14/14
20140227274
Prevention and treatment of amyloidogenic disease
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient.
08/14/14
20140227270
Bispecific anti-cxcr7 immunoglobulin single variable domains
The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting cxcr7 mediated tumour growth..
08/14/14
20140227267
Bovine fusion antibodies
Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (cdr3h) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the cdr3h.
08/14/14
20140227266
Nogo receptor antagonists
Disclosed are immunogenic nogo receptor-1 polypeptides, nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are nogo receptor antagonist polynucleotides.
08/14/14
20140227264
Drug fusions and conjugates with extended half life
The present invention relates to drug fusions and conjugates that have improved serum half lives. These fusions and conjugates comprise immunoglobulin (antibody) single variable domains and insulinotropic and/or incretin and/or gut peptide molecules.
08/14/14
20140227263
Use of fgfr1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in fgfr2
The present invention relates to the use of fibroblast growth factor receptor i (fgfr1) extracellular domain (ecd) polypeptides for treatment of cancers characterized by ligand dependent activating mutations in fibroblast growth factor receptor 2 (fgfr2). For example, the present invention relates to the treatment of endometrial cancers and other cancers wherein tumor cells express fgfr2 mutants in the igii-igiii hinge region or igiii domain of the protein, such as at amino acid positions 252 and/or 253..
08/14/14
20140227259
Modified proteins and peptides
The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise c-terminal additions, extensions or tags and/or certain amino acid substitutions.
08/14/14
20140227254
Antagonists of bmp9, bmp10, alk1 and other alk1 ligands, and uses thereof
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase i (alk1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of bmp9 and/or bmp10, ligands for alk1, may also be used to inhibit angiogenesis in vivo..
08/14/14
20140227238
Peptides having protective effect towards the inflammatory activity of peptide 31-43 of a-gliadin in celiac disease
The present invention concerns peptides having protective effect towards inflammatory activity of a-gliadin 31-43 peptide in celiac disease and therefore can be used for preventive and therapeutic purpose by administration thereof to subjects at high risk to develop celiac disease and/or celiac subjects just before a gluten containing meal to be ingested.. .
08/14/14
20140227185
Glutathione-based drug delivery system
The invention relates to methods of targeted drug delivery of compounds, including, chemical agents, (poly)peptides and nucleic acid based drugs (like dna vaccines, antisense oligonucleotides, ribozymes, catalytic dna (dnazymes) or rna molecules, sirnas or plasmids encoding thereof). Furthermore, the invention relates to targeted drug delivery of compounds to extravascular and intracellular target sites within cells, tissues and organs, in particular to target sites within the central nervous system (cns), into and across the blood-brain barrier, by targeting to glutathione transporters present on these cells, tissues and organs.
08/14/14
20140227181
Method of labelling a biologically active molecule with 5-fluoro-5-deoxypentose or a 3-fluoro-3-deoxypentose
The invention provides a conjugate of a biologically active molecule and a 5-fluoro-5-deoxypentose or a 3-fluoro-3-deoxypentose, wherein the biologically active molecule is selected from the group consisting of proteins, peptides, nucleic acids, oligosaccharides and polysaccharides.. .
08/14/14
20140227180
Antibody-sn-38 immunoconjugates with a cl2a linker
The present invention concerns improved methods and compositions for preparing sn-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the sn-38 is attached to the antibody or antibody fragment using a cl2a linker, with 1-12, more preferably 6 or less, most preferably 1-5 sn-38 moieties per antibody or antibody fragment.
08/14/14
20140227174
Skin permeating and cell entering (space) peptides and methods of use therefor
Compositions that facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (sc) and/or the cellular membranes of viable cells are provided. In some embodiments, the compositions include a peptide, an active agent, and a carrier that includes the active agent, wherein the peptide has an amino acid sequence set forth in any of seq id nos: 1-18; the peptide is associated with and/or conjugated to the active agent, the carrier, or both; the carrier is selected from the group consisting of a micelle, a liposome, an ethosome, and combinations thereof; and the composition is capable of penetrating a stratum corneum (sc) layer when contacted therewith or penetrating a cell when contacted therewith, and optionally wherein the composition further includes one or more free peptides having an amino acid sequence set forth in any of seq id nos: 1-18.


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This listing is a sample listing of patent applications related to Peptide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Peptide with additional patents listed. Browse our RSS directory or Search for other possible listings.
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