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Therapy for constipation

Therapy for constipation

Systems, environment and methods for identification and analysis of recurring transitory physiological states and events…

Systems, environment and methods for identification and analysis of recurring transitory physiological states and events…


Date/App# patent app List of recent Patio-related patents
08/20/15
20150231213 
 Nutritional compositions containing a prebiotic and lactoferrin and uses thereof patent thumbnailNutritional compositions containing a prebiotic and lactoferrin and uses thereof
Provided is a composition and method for modulating serotonergic receptor expression, reducing anxiety-like behavior and stress-induced inflammatory response in a pediatric subject, the method including administering to the pediatric subject a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides. Further provided is a method for reducing constipation in a pediatric subject by providing a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides..
Mead Johnson Nutrition Company


08/20/15
20150231139 
 Therapy for constipation patent thumbnailTherapy for constipation
A method is disclosed of treating acute, sub-acute or chronic constipation in a patient having a condition requiring such treatment. The method includes administering a lipase inhibitor.

08/13/15
20150223731 
 Systems, environment and methods for identification and analysis of recurring transitory physiological states and events using a wearable data collection device patent thumbnailSystems, environment and methods for identification and analysis of recurring transitory physiological states and events using a wearable data collection device
In one aspect, the systems, environment, and methods described herein support anticipation and identification of adverse health events and/or atypical behavioral episodes such as autistic behaviors, epileptic seizures, heart attack, stroke, and/or narcoleptic “sleep attacks” using a portable data collection device. In another aspect, the systems, environment, and methods described herein support measurement of motions and vibrations associated with recurring transitory physiological states and events using a portable data collection device.

08/06/15
20150216806 
 Laxative compositions and methods for treating constipation and related gastrointestinal diseases and conditions patent thumbnailLaxative compositions and methods for treating constipation and related gastrointestinal diseases and conditions
In alternative embodiments, the invention provides compositions, e.g., formulations or preparations, used for treating, ameliorating or preventing constipation and other disorders with related gastrointestinal symptoms. In alternative embodiments, the invention provides compositions, e.g., formulations or preparations, used for treating, ameliorating or preventing conditions which benefit from increasing or speeding bowel transit, including for example: cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue syndrome (cfs), bloating, proctalgia fugax, small intestinal bacterial overgrowth (sibo) and large intestinal bacterial overgrowth (libo), chronic nausea, functional dyspepsia and bloating.
Salix Pharmaceuticals, Inc.


07/30/15
20150210646 
 Benzomorphan compounds as opioid receptors modulators patent thumbnailBenzomorphan compounds as opioid receptors modulators
The present invention is directed to benzomorphan analog compounds of the formula (i), formula (ia), formula (ib), formula (ic), or formula (id) as shown below, wherein r1, r2a, r2b, r3, r4, z, and g are as defined herein. Compounds of the invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and orl-1 receptors..
Purdue Pharma L.p.


07/23/15
20150203504 
 Buprenorphine analogs patent thumbnailBuprenorphine analogs
Compounds of the invention may be useful for preparing medicaments useful for treating pain, constipation, and other conditions modulated by activity of opioid and orl-1 receptors. Compounds of the invention may be useful for treating conditions such as pain, constipation, and others modulated by activity of opioid and orl-1 receptors..

07/09/15
20150192914 
 Automation and control system with inference and anticipation patent thumbnailAutomation and control system with inference and anticipation
An automation system is disclosed in which a system controller has access to the signals transmitted by each sensor device that is relevant to the environment being controlled. Each sensor device monitors a particular physical condition, senses changes in the condition being monitored, and reports states of the condition, which is made available to the system controller.
Etc Sp. Z.o.o.


07/09/15
20150190634 
 Neuromodulatory  treating functional gastrointestinal disorders patent thumbnailNeuromodulatory treating functional gastrointestinal disorders
One aspect of the present disclosure relates to a method for treating a functional gastrointestinal (gi) disorder in a subject, such as functional dyspepsia or functional constipation. One step of the method can include inserting a therapy delivery device into a vessel of the subject.
Ohio State Innovation Foundation


06/18/15
20150172958 
 Predictive load balancing patent thumbnailPredictive load balancing
Managing connections to be established between clients and access points for the purposes of accessing wireless services is contemplated. The connections may be managed according to a predictive load balancing strategy where connections may be established and adjusted in anticipation of predicted client demands, such as to achieve an optimized throughput..
Cable Television Laboratories, Inc.


06/18/15
20150169691 
 Pre-fetching information in anticipation of a user request patent thumbnailPre-fetching information in anticipation of a user request
A system may pre-fetch search result information in anticipation of a user request for the search result information. The system may receive a user search query and request initial search results from a server based on the search query.
Google Inc.


06/11/15
20150163320 

Social-driven precaching of accessible objects


A precaching system identifies an object, such as a media file, that a user accesses and then analyzes a social graph of the user to identify social graph contacts that may be interested in the object. Based on the content of the object—and the interests and connections of contacts in the social graph—the precaching system determines whether a particular contact in the user's social graph is likely also to access the object.
Cisco Technology, Inc.


06/11/15
20150160655 

Automatic guidance system with stability control for an agricultural vehicle


A non-transitory computer-readable medium may store computer executable code. The computer executable code may include instructions to identify a turn to be taken by an agricultural vehicle and to receive a first set of data from at least one of a spatial locating system, one or more speed sensors, and one or more measurement devices.
Cnh Industrial America Llc


06/04/15
20150156440 

Apparatus, a media device pre-operation


Systems and methods are operable to perform pre-operations at a media device in anticipation of an occurrence of a user action. An exemplary embodiment receives an in-use signal from an electronic device that is remotely proximate to the media device, wherein the received in-use signal corresponds to a user interaction with the electronic device; and performs the pre-operation at the media device.
Echostar Ukraine Llc


06/04/15
20150153935 

Reservation system


A reservation system associated with an app installed on a user device can be used to regulate access to network-based features of a primary software service offered by the app. Network-based features can include providing access to online content items.
Dropbox, Inc.


06/04/15
20150150863 

Compositions and methods for treating pelvic pain and other conditions


Methods are provided for treating conditions including chronic pelvic pain, in which there are palpable trigger points of local areas of muscle restriction and spasticity that recreate or refer pain of patients complaints upon palpation, chronic pelvic pain syndrome, pelvic floor myalgia, pelvic floor dysfunction, interstitial cystitis, levator ani syndrome, coccygodynia, prostatodynia, piriformis syndrome, anal sphincter pain, bowel movement pain, post bowel movement pain, ejaculatory pain, post ejaculatory pain, sitting pain, post bowel movement pain, rectal pain, tailbone pain, urinary frequency, urinary urgency, urinary hesitancy, post urinary pain, overactive bladder, perineal pain, penile pain, vaginismus, anismus, sexual dysfunction, reduced level of ejaculate or reduced penile erection, myofascial pain in muscle tissue of a patient who has one or more trigger points in the muscle tissue, or the pain/sensitivity of pelvic floor muscle trigger points and specific areas of myofascial restriction detected upon palpation in a patient comprising administering to the one or more trigger points of the patient in need thereof a therapeutically effective amount of a calcium channel blocker, or l-arginine, or a combination of a calcium channel blocker and l-arginine, or pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof; the application of the topical form of the drug can be applied by the patient regularly as part of a self treatment program to heal muscle related pain and muscle related pelvic pain and each optionally together with a corticosteroid such as cortisone of hydrocortisone. The invention further provides methods for myofascial release, trigger point release, and the use of dilators with and without calcium channel blockers for pain conditions.

05/28/15
20150143977 

System for calculating the tempo of music


A music tempo calculation system uses a microphone to input ambient music; the input is then processed in real time to display beats per minute (bpm). Input from the microphone is decomposed by a detector into a plurality of digital signals ranging from a most sensitive signal to a least sensitive signal.
Clevx, Llc


05/21/15
20150141631 

Pyrazole derivative and use thereof for medical purposes


The present invention provides pyrazole derivatives, uses thereof for medical purposes and so on. More particularly, the present invention relates to pharmaceuticals useful for the prevention or treatment of constipation, which comprise as an active ingredient 3-(3-{4-[3-(β-d-glucopyranosyloxy)-5-isopropyl-1h-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide, or a pharmaceutically acceptable salt thereof.
Kissei Pharmaceutical Co., Ltd.


05/14/15
20150134161 

Load-based vehicle operating control


A hybrid electric vehicle includes an engine and an electric machine, both capable of providing propulsion power. A clutch is configured to selectively couple the engine to the electric machine.

05/14/15
20150129871 

Semiconductor device


A semiconductor device includes a transistor, a light-emitting element, a first wiring, a driver circuit having a function of controlling the potential of the first wiring, a second wiring, a first switch, a second switch, a third switch, a fourth switch, a first capacitor, and a second capacitor. One of a source and a drain of the transistor is connected to the light-emitting element.

05/07/15
20150128123 

System and preparing vehicle for remote reflash event


Implementations of the present disclosure contemplate utilizing the communicative connections between a telematics service provider (tsp) and a telematics unit in a vehicle to schedule a remote reflash event, issue instructions to the vehicle to prepare for the remote reflash event, and to administer the remote reflash event. A tsp may determine that the vehicle is presently running software for which an update is desirable.
General Motors Llc


04/30/15
20150119322 

Nutritional compositions containing a prebiotic and lactoferrin and uses thereof


Provided is a composition and method for modulating serotonergic receptor expression, reducing anxiety-like behavior and stress-induced inflammatory response in a pediatric subject, the method including administering to the pediatric subject a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides. Further provided is a method for reducing constipation in a pediatric subject by providing a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides..
Mead Johnson Nutrition Company


04/30/15
20150118665 

System and anticipating activity


A system for anticipating activity includes an apparatus for anticipating activity. The apparatus includes an activity anticipation module that anticipates an activity based on an archive.
Jaybird Llc


04/30/15
20150117035 

Heat sink for chip mounting substrate and manufacturing the same


Provided is a heat sink for a chip mounting substrate in which a heat dissipation material is embedded. The heat sink includes: an accommodation portion configured to accommodate a substrate whereon a chip is mounted or to be mounted, and support or fix the accommodated substrate; and a heat dissipation portion configured to insulate the accommodated substrate, and dissipate heat generated from the substrate or the chip mounted on the substrate to an outside through a heat dissipation material contained in the heat dissipation portion.
Point Engineering Co., Ltd.


04/23/15
20150112284 

Implantable medical devices including septum-based indicators


An access port for providing subcutaneous access to a patient is disclosed. The access port includes a septum including palpable identification indicia thereon.
C.r. Bard, Inc.


04/23/15
20150106992 

Article of apparel


The present invention is directed toward an article of apparel effective to regulate the temperature of the wearer. In an embodiment, the article of apparel includes a base textile with a thermal regulation membrane.
Under Armour, Inc.


04/09/15
20150099762 

Compounds as rearranged during transfection (ret) inhibitors


This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ret dysfunction or where modulation of ret activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (ibs) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, von hippel-lindau syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased ret kinase activity.. .
Glaxosmithkline Intellectual Property Development Limited


04/09/15
20150099713 

Method of treating constipation-predominant irritable bowel syndrome


Disclosed is a method of manipulating the rate of gastrointestinal transit in a mammalian subject. Also disclosed is the use, in the manufactiurc of a medicament for the treatment of constipation, of a selective inhibitor of methanogensis, a methanogen-displacing probiotic agent, or a prebiotic agent that inhibits the growth of methanogenic bacteria or promotes the growth of competing non-methanogenic intestinal flora.
Cedars-sinai Medical Center


04/02/15
20150095608 

Verification of dynamic logical partitioning


Embodiments of the present invention disclose a method, computer program product, and system for verifying transitions between logical partition configurations. A computer system divides the physical resources of a processing core into logical partitions, each of which has at least one processing subcore.
International Business Machines Corporation


04/02/15
20150095607 

Verification of dynamic logical partitioning


Embodiments of the present invention disclose a method, computer program product, and system for verifying transitions between logical partition configurations. A computer system divides the physical resources of a processing core into logical partitions, each of which has at least one processing subcore.
International Business Machines Corporation


04/02/15
20150094272 

Treatments for gastrointestinal disorders


The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (ibs), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (gerd), duodenogastric reflux, crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase c (gc-c) receptor.. .
Ironwood Pharmaceuticals, Inc.


04/02/15
20150094265 

Treatments for gastrointestinal disorders


The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (ibs), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (gerd), duodenogastric reflux, crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein. Using peptides and other agents that activate the guanylate cyclase c (gc-c) receptor..
Ironwood Pharmaceuticals, Inc.


03/26/15
20150087412 

Gaming system having eligibility routine for group play


Embodiments of the present invention set forth systems, apparatuses and methods for implementing an eligibility routine for group play involving one or more gaming devices. This routine includes making at least two distinct determinations regarding trigger conditions that need to be met before proceeding to a group play game event, such as a community bonus.
King Show Games, Inc.


03/19/15
20150080377 

Deuterium-enriched pyridinonecarboxamides and derivatives


Are partial or full agonists of serotonin (5-hydroxytryptamine or 5-ht) receptor subtype 4 (5-ht4), and are useful compounds for the prevention and treatment of alzheimer's disease, cognitive and memory dysfunction, mild cognition impairment, memory decline, cognitive impairment associated with schizophrenia, cognitive impairment associated with age-related dementia or alzheimer's disease, cognitive impairment associated with post-coronary bypass surgery, attention deficit hyperactivity disorder, obsessive compulsive disorder, depression, speech improvement in autistic children, sleep apnea in alzheimer's patients, age-related macular degeneration (amd), irritable bowel syndrome, gastroesophageal reflux disease, crohn's disease, emesis, nausea, vomiting, prokinesia, non-ulcer dyspepcia, anxiety, depression, pain, migraine, urinary incontinence, arterial fibrillation, arrhythmia, ischemic stroke, gastric emptying disorders, gastritis, gastrointestinal disorders, feeding disorders, obesity, anorexia, constipation, respiratory depression, and erectile dysfunction.. .

03/12/15
20150069455 

Heat dissipation material and light emitting diode package including a junction part made of the heat dissipation material


Disclosed are a heat dissipation material comprising a metallic glass and an organic vehicle and a light emitting diode package including at least one of a junction part, wherein the junction part includes a heat dissipation material including a metallic glass.. .

03/12/15
20150068114 

Control of ground surface radiative effects


Here invented is method and apparatus for control of ground surface radiative effects. A material is laid out in a field in anticipation of frost or in expectation of crop damage from powdery mildew.

03/05/15
20150066494 

Smart circular audio buffer


An audio buffer is used to capture audio in anticipation of a user command to do so. Sensors and processor activity may be monitored, looking for indicia suggesting that the user command may be forthcoming.
Amazon Technologies, Inc.


02/26/15
20150058641 

Adaptive power management of a cluster of host computers using predicted data


A power management system and method for performing power management operations in a distributed computer system uses predicted resource demands for a specified time in the future to change a power management option of a power management analysis algorithm prior to the specified time so that the power management analysis algorithm can be executed in anticipation of the predicted resource demands at the specified time.. .
Vmware, Inc.


02/26/15
20150057235 

Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders


The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase.
Synergy Pharmaceuticals, Inc.


02/26/15
20150055588 

Csi and ack reporting enhancements in lte/lte-a with unlicensed spectrum


Channel state information (csi) and acknowledgement (ack) reporting enhancements in long term evolution (lte)/lte-advanced (lte-a) enabling communications over an unlicensed spectrum are disclosed. For example, ack/nak may include unlicensed spectrum interference information, such as wifi interference.
Qualcomm Incorporated


02/12/15
20150046047 

Transmission with power downshift anticipation logic


A vehicle includes an internal combustion engine, an engine control module (ecm) programmed to estimate engine torque as a function of throttle request, and a transmission assembly. The transmission assembly includes a plurality of gear sets and clutches, including an offgoing clutch and an oncoming clutch for a power downshift, and a transmission control module (tcm).
Gm Global Technology Operations Llc


02/12/15
20150045555 

Conjugate of polyethylene gylcol and naloxone and pharmaceutical composition and use thereof


Provided are a peg-naloxone conjugate of general formula (ii) and a pharmaceutical composition comprising the conjugate. In the conjugate, n is an integer in the range of 1-20.
Jenkem Technology Co., Ltd. (tianjin)


02/12/15
20150045364 

Pyridine and pyrazine derivative for the treatment of cf


The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type cftr to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (ibs, ibd, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed..
Novartis Ag


02/12/15
20150043562 

Wireless network discovery method and apparatus


In a wireless network discovery operation, before a wifi station sends a network probe request in a wifi network to request for network information it needs to connect to an access point, it first listens to communications on a current channel of the wifi network for a preset period of time. When the wifi station receives on the current channel a network probe request message sent by another wifi station, it further delays sending the first network probe request by a second time period, in anticipation of some signals from the access point.
Huawei Device Co., Ltd.


01/29/15
20150031344 

Apparatuses and methods for downloading data


A method and network apparatus for downloading data from the network apparatus to a mobile device in anticipation of the mobile device entering a black spot zone. The network apparatus determines that the mobile device has entered a predetermined tracking zone related to the black spot zone and gathers information for defining a download zone for the mobile device taking into consideration a time necessary for downloading the data to the mobile device, and a predicted time interval until the mobile device enters the black spot zone.
Telefonaktiebolaget L M Ericsson (publ)


01/29/15
20150030697 

Treatments for gastrointestinal disorders


The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.. .
Ironwood Pharmaceuticals, Inc.


01/08/15
20150011894 

System for and quantifying on-body palpitation for improved medical diagnosis


A haptic sensor for performing palpation includes a deformable membrane having a reflective surface, a light source, a camera, and a processor. When the sensor is pressed against an object on a body, the deformable membrane deforms to contour to the shape of the object, light is reflected off the reflective surface, and captured by a camera.
The Regents Of The University Of California


01/01/15
20150006959 

Packet loss anticipation and preemptive retransmission for low latency media applications


In many low latency media applications it is important to transmit media data packets from a media source to one or more media destinations as promptly as possible, while also ensuring that all media data packets that may be lost due to transmission errors are retransmitted and received correctly at the media destination. This invention described a system to do this with a system and methods for anticipating media data packet loss and making preemptive media data packet retransmission requests by dynamically computing a metric and decision logic for retransmission request that includes a need based factor from the media consuming application..
Blackfire Research Corporation


12/25/14
20140379553 

Method and a system for sending an electronic message


Disclosed is a system for reducing latency. A message sender can send to an electronic message receiver an electronic message portion comprising at least one of a plurality of data packages for transmission that an electronic message has been divided between.
Zomojo Pty Ltd


12/18/14
20140372345 

Contextual prediction of user words and user actions


An operating sequence for a handheld computing device manages the device to automatically detect cues describing the device's environmental and user actions performed with the device, learn which cues and cue combinations are relevant to predict user actions, and then in response to occurrence of the relevant cues, predictively implementing the appropriate user action or configuring the device in anticipation of user action.. .
Nuance Communications, Inc.


12/18/14
20140372161 

Method for generating a discrete forecasted staff report


A computer-implemented method is disclosed for generating a discrete forecasted staff report. The method commences with the definition of a set of shifts, each shift having daily and weekly time segments.
Wal-mart Stores, Inc.


12/18/14
20140371255 

Non-peptidyl, potent, and selective mu opioid receptor antagonists and their use in treating opioid addiction and opioid induced constipation


Selective, non-peptide antagonists of the mu opioid receptor (mor) and methods of their use are provided. The antagonists may be used, for example, to identify mor agonists in competitive binding assays, and to treat conditions related to addiction in which mor is involved, e.g.
Virginia Commonwealth University


12/11/14
20140364448 

Quarternized buprenorphine analogs


The present invention is directed to buprenorphine analog compounds of the formula (i), formula (ia) or formula (ib) shown below, wherein r1, r1a, r2, r8, r3a, r3b, g, x, z, y, and a® are as defined herein. Compounds of the invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and orl-1 receptors..

12/11/14
20140364373 

Novel enteric combination therapy


There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers' diarrhoea, chronic idiopathic nausea, ibd-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, parkinson's disease, ms, alzheimer's disease, motor neurone disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers' diarrhoea, chronic idiopathic nausea, ibd-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, parkinson's disease, ms, alzheimer's disease, motor neurone disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment..

12/11/14
20140362830 

Enhancing jitter buffer performance through radio level feedback


A jitter buffer in a voice over lte receiver may be influenced by radio level feedback (rlf) from both local and remote endpoints to preemptively adjust the jitter buffer delay in anticipation of predicted future losses that have a high probability of occurring. The radio events of the rlf and the scenarios that trigger the preemptive adjustments may be identified, and their use may be expressed in terms of mathematical formulas.

11/27/14
20140350341 

Patient colonoscopy abdominal compression device and method


A patient colonoscopy abdominal compression device and method. Spaced pressure columns are configured to press on the iliac.

11/27/14
20140349948 

Treatment of chronic constipation


The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide.. .

11/20/14
20140342996 

Treatments for gastrointestinal disorders


The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.. .

11/06/14
20140330118 

Assemblies for identifying a power injectable access port


An assembly for identifying a power injectable vascular access port, including a vascular access port and an identification feature. The port is structured for power injection and includes a housing and a septum together defining a reservoir.

11/06/14
20140330068 

Method for modulating the enteric nervous system to treat a disorder


Non-invasive and/or natural orifice procedures, apparatus and methods for modulating the enteric nervous system using one or more energy modalities. A system may include a probe for insertion into a natural orifice (e.g., nasogastrically, orogastrically, nasojejunally) with or without a tube to therapeutically apply energy to modulate one or more portions of the enteric nervous system.

11/06/14
20140329765 

Methods and compositions for the treatment of gastrointestinal disorders


Compositions and related methods for treating ibs and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (gerd), duodenogastric reflux, crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase c (gc-c) receptor..

11/06/14
20140329738 

Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders


The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase.

11/06/14
20140328112 

Memory cell supply voltage reduction prior to write cycle


An integrated circuit device includes a memory cell coupled to a supply voltage line to receive a supply voltage and a voltage control circuit operable to reduce a magnitude of the supply voltage prior to a write cycle to the memory cell. The voltage control circuit includes a first capacitor that is selectively coupled between a supply voltage line and a first reference supply voltage line of the integrated circuit device in anticipation of a write cycle to the memory cell..

10/30/14
20140325343 

Systems and methods for processing web page data


Described herein are systems and methods for processing web page data. In overview, these make use of a downloadable api thereby to allow client-side processing of web page data (for example html data) in a manner that facilitates efficient generation of a web page, with the capability to execute scripts (such as scripts relating to advertising content) following the generation of a complete document object model (dom).

10/30/14
20140323920 

Stabilized device for remote palpation of tissue in two non-collinear directions


Described embodiments include a handheld or hand operated device and a method. The method includes contacting a skin surface of a patient and palpating tissue in two non-collinear directions using a tip of a palpation element carried by a handheld or hand operated device.

10/30/14
20140323904 

Stabilized device for remote palpation of tissue


Described embodiments include a handheld or hand operated device and a method. The method includes contacting a skin surface of a patient and palpating a tissue using a palpation element, the palpation element carried by a handheld or hand operated device and movable with respect to the handheld or hand operated device.

10/30/14
20140322302 

Therapeutic peptides


Therapeutic peptides having guanylyl cyclase c agonist activity are disclosed. The therapeutic peptides are analogues of the e.

10/23/14
20140313955 

System and uplink timing synchronization in conjunction with discontinous reception


Systems and methods for controlling sounding reference signal transmission are provided; a user equipment starts transmitting the sounding reference signal in anticipation of uplink data transmission, and then discontinues transmitting the sounding reference signal after completion of uplink data transmission.. .

10/09/14
20140303095 

Novel peptidomimetics and their application


Novel peptidomimetics exhibiting affinity for opioid receptors, possessing general formula show on fig. 1, for gastrointestinal or peripheral administration in the form of a pill, infusion, injection or implant in the treatment of peripheral opioids side effects, particularly constipation or/and respiratory depression..

10/02/14
20140298388 

Technique for providing program guide data through a communications network delivering programming content


In order to efficiently utilize the limited transmission bandwidth of a communications network, e.g., a cable network, guide data for constructing an interactive program guide (ipg) is delivered to a set-top terminal using different methodologies. For example, the guide data associated with those programs which are likely of interest to a user is automatically provided piecemeal in a broadcast stream.

10/02/14
20140298117 

Detection of user behavior using time series modeling


The embodiments provide a way to predict when a storage device will be accessed. In order to enhance performance, the storage device may proactively prepare for the access operation, and thus, minimize the access-time response of the storage device.

10/02/14
20140296163 

Methods and compositions for the treatment of gastrointestinal disorders


Compositions and related methods for treating ibs and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (gerd), duodenogastric reflux, crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase c (gc-c) receptor..

09/25/14
20140283821 

Introducer for surgical airway catheters


In one embodiment, an introducer has a round handle; a first curved, flattened (i.e., oval) section connected to the handle; a first straight, unflattened (i.e., circular) section connected to the first curved section; a second curved, flattened section connected to the first straight section; and a last straight, unflattened section connected to the second curved section. The curved, flattened sections allow the introducer to unbend in the anterior-posterior direction to enable a user to introduce a tube or other airway catheter into a surgical airway.

09/18/14
20140278465 

Method, apparatus, and system for providing health monitoring event anticipation and response


A contact center is described along with various methods and mechanisms for administering the same. In particular, the contact center may be configured to execute a work assignment engine and the contact center may also contain a health monitoring module that is configured to monitor events in the work assignment engine, compare the monitored events with a grammar defining expected events and an expected sequence of the expected events, and determine whether the work assignment engine is behaving appropriately based on the comparison..

09/18/14
20140275117 

Buprenorphine analogs


Compounds of the invention may be useful for preparing medicaments useful for treating pain, constipation, and other conditions modulated by activity of opioid and orl-1 receptors. Compounds of the invention may be useful for treating conditions such as pain, constipation, and others modulated by activity of opioid and orl-1 receptors..

09/18/14
20140275111 

Novel compounds as rearranged during transfection (ret) inhibitors


This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ret dysfunction or where modulation of ret activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (ibs) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, von hippel-lindau syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased ret kinase activity.. .

09/11/14
20140259170 

Internet security cyber threat reporting system and method


A risk assessment and managed security system for network users provides security services for dealing with formidable cyber threats, malware creations and phishing techniques. Automated solutions in combination with human-driven solutions establish an always-alert positioning for incident anticipation, mitigation, discovery and response.

09/11/14
20140259067 

Apparatus, pre-tuning a second tuner in anticipation of a channel surfing activity


Two-tuner media device systems and methods are operable to pre-tune a second tuner in anticipation of a channel surfing activity. An exemplary embodiment receives a first content stream associated with a currently presented channel at a first tuner, determines an anticipated channel based upon the currently presented channel and a historical channel surfing pattern, receives a second content stream associated with the anticipated channel at a second tuner, detects an initiation of a channel surfing activity, and presents at least a video portion of the second content stream associated with the anticipated channel in response to detecting the initiation of the channel surfing activity..

08/28/14
20140244013 

Pre-caching of audio content


Embodiments are provided for causing a playback device to pre-cache audio content in anticipation that a user will provide input to cause the playback device to render the audio content. The playback device may be configured to detect, using a proximity sensor on the playback device, movement in relation to the playback device, responsively retrieve audio content by the playback device from a networked audio source, prior to receiving a user command to play the audio content, storing the audio content in memory on the playback device, and cause the playback device to render the audio content upon receiving the user command.

08/21/14
20140236434 

System and route identification using a low cost gps system


A system and method for identifying and analyzing a route using an inexpensive gps system is provided. The system and method provides a location for storing gps and vehicle operating data for at least one route, requiring a plurality of runs over the at least one route.

08/21/14
20140235665 

Anti-constipation composition


Where x1 and x2 are preferably both fluorine atoms. The composition can be used to treat constipation without substantive side-effects, such as stomachache..

08/21/14
20140235532 

Immunogenic escherichia coli heat stable enterotoxin


The present invention relates to methods and compositions for the treatment and prevention of diarrhea and diarrheal related diseases and disorders in both animals and humans. In some embodiments, the invention relates to the treatment of said diarrhea and diarrheal related diseases and disorders with a vaccine.

08/21/14
20140232291 

Semiconductor device


A semiconductor device includes a transistor, a light-emitting element, a first wiring, a driver circuit having a function of controlling the potential of the first wiring, a second wiring, a first switch, a second switch, a third switch, a fourth switch, a first capacitor, and a second capacitor. One of a source and a drain of the transistor is connected to the light-emitting element.

08/14/14
20140228431 

Method of treating constipation


Disclosed is a method of manipulating the rate of gastrointestinal transit in a mammalian subject. Also disclosed is the use, in the manufacture of a medicament for the treatment of constipation, of a selective inhibitor of methanogensis, a methanogen-displacing probiotic agent, or a prebiotic agent that inhibits the growth of methanogenic bacteria or promotes the growth of competing non-methanogenic intestinal flora.

08/14/14
20140228376 

Heterocyclic compounds for the treatment of cf


The present invention provides pyridin-oxadiazole/thiadiazole derivatives of formula i wherein a is n or cr 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type cftr to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (ibs, ibd, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed..

08/07/14
20140221419 

Benzomorphan analogs and the use thereof


Compounds of the invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and orl-1 receptors.. .

07/31/14
20140214889 

Anticipatorily retrieving information in response to a query of a directory


A technique includes receiving a query to a directory in a file system. In response to the query, both information targeted by the query and additional information are retrieved in anticipation of another query for the additional information..

07/31/14
20140212863 

Pregnant abdominal system and associated devices, systems, and methods


Simulated pregnant abdominal systems and associated devices, systems, and methods are provided. The pregnant abdominal systems allow an interactive scenario simulating a routine gestation palpation of a fetal baby, the performance of an external cephalic version as well as the leopold's maneuvers.

07/31/14
20140212494 

Methods of improving digestive health


A method of treating constipation is disclosed. The method includes administering starch-entrapped microbeads..

07/24/14
20140205989 

System and detecting a point of originality in a writing


This paper proposes a new method for the objective evaluation of student work through the identification of original content in writing assignments. Using wordnet as a lexical reference, this process allows instructors to track how key phrases are employed and evolve over the course of a student's writing, and to automatically visualize the point at which the student's language first demonstrates original thought, phrased in their own, original words.

07/17/14
20140201836 

Automated internet threat detection and mitigation system and associated methods


A risk assessment and managed security system for network users provides security services for dealing with formidable cyber threats, malware creations and phishing techniques. Automated solutions in combination with human-driven solutions establish an always-alert positioning for incident anticipation, mitigation, discovery and response.

07/17/14
20140198882 

Systems, apparatus, and methods for receiving paging messages by creating fat paths in fast fading scenarios


This disclosure provides systems, methods, and apparatus for receiving paging messages in fast fading scenarios. In one aspect, a method of demodulating a paging message during an assigned time slot by a wireless communications apparatus operating in an idle mode is provided.

06/26/14
20140181818 

Optimization of packet processing by delaying a processor from entering an idle state


Some embodiments facilitate high performance packet-processing by enabling one or more processors that perform packet-processing to determine whether to enter an idle state or similar state. As network packets usually arrive or are transmitted in batches, the processors of some embodiments determine that more packets may be coming down a multi-stage pipeline upon receiving a first packet for processing.

06/26/14
20140181288 

User profile-based wireless device system level management


Techniques for user profile-based system level management (slm) and creation of system level agreements of a wireless device are generally disclosed. In some examples, a predictor may be provided to predict a future task to be performed by a wireless device, including resource requirements, based at least in part on a profile of a user and at least one of a profile of a communication partner the user, an operational recommendation, a performance model or a current state.

06/19/14
20140172451 

Systems and methods for medical information management


Systems and method for communication of information to one or more medical care providers. The systems and methods may utilize a client with which a user may interact.

06/19/14
20140165633 

Air compressor


An air compressor system is disclosed that includes a housing sized to enclose an air compressor pump as well as a dryer structured to remove moisture from air that is compressed by the compressor pump. The air compressor pump may be intermittently placed into operation, but the dryer itself is structured in one form to continuously maintain a heat exchanger in a desired temperature range in anticipation of operation of the air compressor pump.

06/12/14
20140162963 

Treatment of constipation-predominant irritable bowel syndrome


The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.. .



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