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Pathologic patents

      

This page is updated frequently with new Pathologic-related patent applications.




 Dual receptor antagonistic antigen-binding proteins and uses thereof patent thumbnailDual receptor antagonistic antigen-binding proteins and uses thereof
This disclosure relates to antagonistic dual receptor antigen-binding proteins, e.g. Antibodies and methods of using the dual receptor antibodies for treatment of pathological diseases.
Amgen Inc.


 Methods of modulating inflammasome activity to treat inflammatory conditions patent thumbnailMethods of modulating inflammasome activity to treat inflammatory conditions
Compositions and methods for reducing inflammation in the central nervous system (cns) of a mammal that has been subjected to a stroke, traumatic injury to the cns such as traumatic brain injury (tbi), spinal cord injury (sci), or having an autoimmune or cns disease have been developed. The compositions and methods described herein include antibodies that specifically bind to at least one component (e.g., asc, nalp1) in a mammalian inflammasome (e.g., the nalp1 inflammasome) and have use as treatments for sci, tbi, stroke, and autoimmune and cns diseases in a mammal.
University Of Miami


 Haemophilus influenzae type iv pili patent thumbnailHaemophilus influenzae type iv pili
The invention described herein relates to a haemophilus influenzae (h. Influenzae) regulon encoding type iv pili.
Nationwide Children's Hospital, Inc.


 Composition for preventing and treating non-alcoholic fatty liver diseases patent thumbnailComposition for preventing and treating non-alcoholic fatty liver diseases
A composition includes a black chokeberry extract and at least one of a thistle extract, a black hoof mushroom extract and a mixture thereof. The composition is effective in preventing and treating non-alcoholic fatty liver disease caused by accumulation of fat in the liver due to excessive intake of nutrients or metabolic syndrome regardless of alcohol intake.
Jbk Natural Medicine Institute


 Mouse model of retinal degeneration patent thumbnailMouse model of retinal degeneration
The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (amd).
The Cleveland Clinic Foundation


 Anti-angiogenesis therapy for the treatment of breast cancer patent thumbnailAnti-angiogenesis therapy for the treatment of breast cancer
This invention concerns in general treatment of diseases and pathological conditions with anti-vegf antibodies. More specifically, the invention concerns the treatment of human subjects susceptible to or diagnosed with breast cancer using an anti-vegf antibody, preferably in combination with one or more additional anti-tumor therapeutic agents..
Genentech, Inc.


 Optimized variants of anti-vegf antibodies patent thumbnailOptimized variants of anti-vegf antibodies
The present invention provides anti-vegf antibodies and compositions that include anti-vegf antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression..
Genentech, Inc.


 Methods for treatment of cd14-mediated disorders and responses patent thumbnailMethods for treatment of cd14-mediated disorders and responses
A method for blocking, inhibiting and/or decreasing cluster of differentiation 14 (cd14) function, cd14-mediated cellular response and/or treating cd14-mediated pathological conditions is disclosed. The method comprises administering to a subject in need thereof a pharmaceutical composition comprising: (a) a therapeutically effective amount of a recombinant protein comprising an amino acid sequence that is at least 80% identical to seq id no: 1, wherein the recombinant protein does not comprises a lectin-like domain 1 of a human thrombomodulin; and (b) a pharmaceutically acceptable vehicle, carrier, diluent, excipients, and/or salt..

 Inhibitors of kidney stone formation and calcium deposition patent thumbnailInhibitors of kidney stone formation and calcium deposition
A pharmaceutical composition for the treatment of pathological calculus and plaque formation is provided. The composition includes conjugates of polymers and metal binding agents that are particularly effective in inhibiting crystal nucleation, growth, and aggregation in the body, such as that observed in the formation of kidney stones.

 Substituted indol-5-ol derivatives and their therapeutical applications patent thumbnailSubstituted indol-5-ol derivatives and their therapeutical applications
The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.. .
Nantbioscience, Inc.


Syndecan peptides and polypeptides and uses thereof

The invention provides for peptides from syndecan 4 and methods of use therefor. These peptides can inhibit α6β4 integrin interaction with egfr, thereby preventing tumor cell growth and tissue invasion, or inhibiting scarring and/or pathologic neovascularization..
Wisconsin Alumni Research Foundation

Capture and analysis of body sounds

One or more body sounds are captured using one or more acoustic sensors placed on one or more locations of a subject. The one or more body sounds are converted into one or more acoustic signals using one or more acoustic transducers.
International Business Machines Corporation

Grading of glandular tissue cancer by detailed image analysis of stained tissue slices

An improved histopathological score is obtained by identifying objects in images of glandular tissue from cancer patients. The objects are identified based on staining by a biomarker.
Definiens Ag

Anti-il1rap antibodies and their use for treating human

The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (il1rap) for use in inducing cell death and/or inhibiting the growth and/or proliferation of cells associated with a solid tumour, wherein the cells express il1rap. A related aspect of the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (il1rap) for use in detecting pathological cells associated with a solid tumour, wherein the cells express il1rap.
Cantargia Ab

Benzoxazepin pi3k inhibitor compounds and methods of use

Benzoxazepin compounds of formula i, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: z1 is cr1 or n; z2 is cr2 or n; z3 is cr3 or n; z4 is cr4 or n; and b is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of pi3k, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of formula i for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
Genentech, Inc.

Compositions and methods relating to proliferative diseases

Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described.
The Penn State Research Foundation

Novel lectins and applications for the detection of pathological state markers

Multimenic lectins having a β-propeller architecture, formed from monomer modules of approximately 30 to 60 amino acids, in which the binding sites to the glycans are situated on a given side of the proteins and the o-terminus and n-terminus ends of the peptide chains on the other side of the proteins, characterized in that they are formed from 4 to 7 monomer modules, a single, or a plurality of, or all of the adjacent modules being linked to one another by the linkers linking the n-terminus end of one module to the c-terminus end of the adjacent module.. .
Universite Joseph Fourier

Pyridone and aza-pyridone compounds and methods of use

Pyridone and aza-pyridone compounds of formula i are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting btk kinase, and for treating immune disorders such as inflammation mediated by btk kinase. Methods of using compounds of formula i for in intro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
Genentch Inc.

Systems and methods for diagnosis of middle ear conditions and detection of analytes in the tympanic membrane

Systems and methods are presented for the diagnosis of middle ear pathological conditions based on spectral signatures. Preferred embodiments provide for detection of one or more analytes from the tympanic membrane.
Connecticut Children's Medical Center

Par-1 activation by metalloproteinase-1 (mmp-1)

Matrix metalloproteases (mmps) play many important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis and cancer. This invention relates to the activation of protease-activated receptor-1 (par-1) by endogenous platelet mmp-1 collagenase on the surface of platelets.
Tufts Medical Center, Inc.

C5ar antagonists

Compounds are provided that are modulators of the c5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of c5a receptors..
Chemocentryx, Inc.

Antimicrobial compositions and methods and uses thereof

The invention relates to inhibitors of a bacterial biofilm formation that target the n′ loop extension of the periplasmic subunit of a bacterial phosphate specific transfer system (psts), specifically, of p. Aeruginosa.
Bar Ilan University

Cloud-based pathological analysis system and method

The present invention relates to a cloud-based pathological analysis system and method. The present invention provides a cloud-based pathological analysis system, including: a client device coupled to a microscope, and configured to acquire an image for a tissue sample via the microscope and generate a sample image; and a cloud server coupled to the client device over a network, and configured to receive sample image data from the client device over the network and store the sample image data; wherein the cloud server analyzes the received sample image data, and transmits analysis information to the client device..
Lunit Inc.

Method for signal and data analysis for determining warning signals for pathological conditions as well as corresponding devices and systems

A method, device, system data analysis determines warning signals for pathological conditions. Measured data is collected from a patient data management system with a data interface.
DrÄgerwerk Ag & Co. Kgaa

Biomarker for diagnosis of irritable bowel syndrome

To provide a biomarker which is a metabolite included in a biological sample, and which can be collected in a noninvasive method and detected in a convenient analysis method, and which varies according to progression of pathological conditions of irritable bowel syndrome (ibs). Furthermore, such biomarkers are useful for determination of the presence or absence of morbidity of ibs, determination of severity of ibs, determination of types of ibs, determination of necessity of treatment of ibs, and confirmation of drug efficacy of an ibs therapeutic agent..
Ono Pharmaceutical Co., Ltd.

Pathologic staging compression apparatus and methods

A filtration assembly for separating solids from liquids contained in a sample, and a method for preparing such a sample are disclosed herein. According to one embodiment, the filtration assembly includes an inner element (100) with proximal and distal ends (102,103) and a sample (200) disposed therein.
Parker Isaac Instruments, Llc

Method of detecting ocular diseases and pathologic conditions and treatment of same

Methods of detecting and treating diseases and pathological conditions of the eye are disclosed. In particular a genetic variant of the htra1 gene is correlated to age related macular degeneration (amd).
University Of Utah Research Foundation

Novel glycosaminoglycan-antagonising fusion proteins and methods of using same

The present invention relates to novel monomeric fusion proteins derived from human gag binding proteins such as chemokines with increased glycosaminoglycan (gag) binding affinity and knocked-out or reduced gpcr activity compared to wild type gag binding proteins, which are highly selectively competitive and are of increased bioavailability, and to their use for prevention or treatment of pathological cell movement as in metastasis.. .
Antagonis Biotherapeutics Gmbh

Active agent-particle combination supporting bone regeneration

The invention provides for a bioactive composition comprising solid particles, such as e.g. Calcium phosphate particles, loaded with an active agent, preferably an osteoconductive/osteoinductive agent or an anti-resorptive agent like a bisphosphonate.
Ecole Polytechnique Federale De Lausanne (epfl)

Fusion proteins for treating pathological blood clots

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed..
Immunwork Inc.

Pharmaceuticals in joint-linker configurations for treating pathological blood clots

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed..
Immunwork Inc.

Multi-arm linker constructs for treating pathological blood clots

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed..
Immunwork Inc.

Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions

Method of using dopamine reuptake inhibitors, e.g., sydnonimine derivatives, for the management of diabetic symptoms and associated complications or conditions, such as hyperglycemia and diabetic neuropathy.. .
Caliper Life Sciences, Inc.

Method of lowering cholesterol

The present invention relates to the diagnosis, risk assessment, prevention, and treatment of senile dementia of the alzheimer's type (sdat). More specifically the present invention relates to the measurement of ethanolamine phospholipids in human serum.
Phenomenome Discoveries Inc.

Surgical linear stapler

Disclosed is a surgical linear stapler comprising: a staple cartridge which is internally loaded with staples for stapling a surgical site; a cartridge accommodating channel which is formed with a cartridge accommodating groove to accommodate the staple cartridge therein; an anvil which corresponds to the staple cartridge and shapes the staple discharged from the staple cartridge; and a cutter which moves along a lengthwise direction of the staple cartridge by external force and cuts a surgical site arranged in between the staple cartridge and the anvil, in which distances from the cutting section of the surgical site to opposite stapling lines are different from each other, thereby stably and conveniently obtaining tissue for pathological examination, which is not damaged by a staple.. .
Medi Tulip Co., Ltd

Biomarkers and methods of treating pd-1 and pd-l1 related conditions

Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using pd-1/pd-l1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto..
Genentech, Inc.

Method of detecting ocular diseases and pathologic conditions and treatment of same

Ocular diseases affecting the macula or the vasculature of the eye affect a wide variety of individuals. In particular, age-related macular degeneration (amd) is the most common cause of irreversible vision loss in the developed world and has a significant genetic predisposition.
University Of Utah Research Foundation

Syndecan peptides and polypeptides and uses thereof

The invention provides for peptides from syndecan 1 and methods of use therefor. These peptides can inhibit α4β6 interaction with her2, thereby preventing tumor cell growth and tissue invasion.
Wisconsin Alumni Research Foundation

Otoscope and otoscopic method based on spectral analysis

The invention relates to an otoscope device (10), especially configured to be manipulated by a layperson during its application, comprising a radiation sensing unit (40.1) configured for detecting radiation reflected by the patient's outer ear, especially by the eardrum; wherein the otoscope device further comprises electronic and/or optic means (44) configured for determining spectral information of reflected radiation, especially with respect to wavelengths shorter than 500 nm to 480 nm, and configured for determining a ratio of radiation in the spectrum below 480 nm to 500 nm to radiation in the spectrum above 480 nm to 500 nm, especially based on a specific intensity of reflected radiation within the spectrum of blue light and/or uv radiation. Further, the invention relates to a method of identifying and/or locating objects in a subject's ear or to a method of identifying or characterizing an eardrum.
Helen Of Troy Limited

Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation

The invention relates to a compound having ssao/vap-1 inhibitor activity for use in the treatment of hyperalgesia and allodynia implicated in traumatic neuropathy or neurogenic inflammation. Accordingly, the invention relates to a compound having ssao/vap-1 inhibitor activity for use in the inhibition of pathological activation and dysfunctions of peptidergic sensory nerves caused by mechanical damage or chemical activation of peptidergic sensory nerves in neurogenic inflammation..
PÉcsi TudomÁnyegyetem

Treatment of abnormal cutaneous scarring

The invention relates to the prevention and treatment of pathologic scars using apc or analogue thereof.. .
Zz Biotech Llc

Intra-operative medical image viewing system and method

An intra-operative medical image viewing system can allow a surgeon to maintain a viewing perspective on the patient while calling-up visual images on-the-fly. A digital image source has at least one image file representative of an anatomical or pathological feature of a patient.
Surgerati, Llc

Device and transmitting and detecting electromagnetic signal propagating through cranial sutures

The embodiments of present invention disclose a device and a method of transmitting and detecting electromagnetic signal propagating through cranial sutures. The device comprises: a positioning strap and a differential amplifier circuit, wherein, the positioning strap on the inside thereof is provided with several electrode pads; at least one of the several electrode pads functions as an emitter electrode pad, at least two of the several electrode pads function as two receiver electrode pads, which are connected to two input terminals of the differential amplifier circuit, respectively; all the electrode pads are arranged on the inside surface of the positioning strap, and the shape of distribution of the electrode pads on the positioning strap matches the shape of at least one cranial suture on a cranium of an object under examination when the strap is placed around.
Chong Qing Born-fuke Medical Equipment Co., Ltd

Methods and kits for determining a personalized treatment regimen for a subject suffering from a pathologic disorder

The invention relates to methods and kits for determining and optimizing a personalized treatment regimen for a subject suffering from a pathologic disorder based on calculating the value of m, that indicates the ability of said subject to eliminate said disorder. The invention specifically relates to optimization of interferon treatment of viral disorders..
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.



Pathologic topics:
  • Pathologic
  • Pharmaceutically Acceptable Salts
  • Pharmaceutically Acceptable Salt
  • Human Papillomavirus
  • Theophylline
  • Inflammation
  • Neurological
  • Intestinal Diseases
  • Gastrointestinal Diseases
  • Gastrointestinal
  • Psychiatric
  • Urogenital
  • Gastrointestinal Disease
  • Inflammatory Disease
  • Blood Typing


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    This listing is a sample listing of patent applications related to Pathologic for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Pathologic with additional patents listed. Browse our RSS directory or Search for other possible listings.


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