 Patent Application Title |
Patent App Num. |
Date |
| Nucleic acid sequences encoding proteins associated with abiotic stress response | 20110321196 | 20111229 |
| The present invention pertains transgenic plant cells and mature plants comprising Oxidoreductase Stress Related Proteins (ORSRP) resulting in increased tolerance and/or resistance to environmental stress as compared to non-transformed wild type cells and methods of producing such plant cells or plants. Further object of the present invention are isolated ORSRPs or ORSRP encoding nucleic acids from plants.
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| Novel modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors | 20110311620 | 20111222 |
| The present disclosure relates to novel dosage forms of xanthine oxidoreductase inhibitors.
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| Flexible fuel cell | 20110287328 | 20111124 |
| Disclosed herein is a flexible fuel cell including, one or a plurality of cell sections, and a sealing sheet covering the cell section or sections, wherein the cell section has, at least, a pair of electrode sheets which form an anode and a cathode and at least one of which is accompanied by an oxidoreductase present at a surface thereof, a separator which is disposed between the electrode sheets and which has a proton-permeable membrane, a pair of current collectors which are electrically conductively connected respectively to the electrode sheets with a conductive adhesive, and a fuel reservoir section which is provided at such a position as to make contact with the anode at least and in which a fuel solution containing a fuel component is... |
| Fuel cell | 20110281183 | 20111117 |
| A fuel cell includes: one or a plurality of cell sections having an electrode with an oxidoreductase present at a surface thereof; and a container in which the cell section or sections are contained; wherein the container is provided with a fuel solution pouring port through which to pour a fuel solution into the cell section or sections, and the fuel solution pouring port is oriented in a fixed direction at least at the time of pouring the fuel solution.
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| Fuel analyzing method and fuel analyzing device for fuel cell, and fuel cell | 20110281182 | 20111117 |
| Disclosed herein is a fuel analyzing method for a fuel cell, including the steps of: measuring a physical property and/or an electric characteristic of a fuel to be used in a biofuel cell having an electrode with an oxidoreductase present at a surface thereof; and determining the quantity of an effective component which contributes to power generation in the fuel, from the physical property and/or the electric characteristic.
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| Enzyme-assisted effluent remediation | 20110278223 | 20111117 |
| This invention relates to methods to reduce the levels of contaminants in effluent produced in industrial operations, e.g., refinery operations. The invention relates to method to reduce the level of organic contaminants in industrial effluent wherein said effluent lacks sufficient dissolved oxygen to support enzymatically-catalyzed removal of organic contaminants comprising adding to the effluent one or more enzymes in an amount effective to reduce the level of organic contaminants in said effluent, wherein said enzymes require oxygen for enzymatic activity; and adding an in-situ source of dissolved oxygen. The enzyme may be an oxidoreductase (laccase, tyrosinase, or other oxidoreductase enzyme which requires oxygen for enzymatic activity).
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| Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding oxidoreductase motif polypeptides | 20110219474 | 20110908 |
| This invention is in the field of plant molecular biology. More specifically, this invention pertains to isolated nucleic acid fragments encoding ORM proteins in plants and seeds and the use of such fragments to modulate expression of a gene encoding ORM protein activity in a transformed host cell.
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| Methods of xylitol preparation | 20110207190 | 20110825 |
| The invention provides spray-dried preparations of microbes useful for oxidoreductase reactions, e.g., xylitol production, and methods of making and using those microbes.
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| Plants with increased yield (lt) | 20110195843 | 20110811 |
| A method for producing a plant with increased yield as compared to a corresponding wild type plant comprising at least the following step: increasing or generating in a plant or a part thereof one or more activities selected from the group consisting of 3-phosphoglycerate dehydrogenase, Adenylate kinase, B2758-protein, Cyclic nucleotide phosphodiesterase, cysteine synthase, Exopolyphosphatase, geranylgeranyl reductase, Mating hormone A-factor precursor, mitochondrial succinate-fumarate transporter, modification methylase HemK family protein, Myo-inositol transporter, oxidoreductase subunit, peptidy-prolyl-cis-trans-isomerase, protein kinase, Ribose-5-phosphate isomerase, slr1293-protein, YDR049W-protein, YJL181W-protein, and YPL109C-protein-activity.
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| Protein electron mediator | 20110136158 | 20110609 |
| The present invention relates to an electron mediator for glucose oxidoreductase comprising extracellular secretion type cytochrome, a fusion body in which the electron mediator is fused with glucose oxidoreductase, a composition for glucose measurement including the electron mediator or fusion body, a gene encoding a new extracellular secretion type cytochrome, and a measurement method using extracellular secretion type cytochrome and an enzyme, an electrode, and a sensor.
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| Protein electron mediator | 20110045513 | 20110224 |
| The present invention relates to an electron mediator for glucose oxidoreductase comprising extracellular secretion type cytochrome, a fusion body in which the electron mediator is fused with glucose oxidoreductase, a composition for glucose measurement including the electron mediator or fusion body, a gene encoding a new extracellular secretion type cytochrome, and a measurement method using extracellular secretion type cytochrome and an enzyme, an electrode, and a sensor.
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| Anti-microbial additive for use in flower vase water | 20110039697 | 20110217 |
| The present invention relates to anti-microbial compositions that may advantageously be added to vase water of cut flowers in order to prevent microbial growth, especially in vase water containing added cut flower nutrients and/or water uptake stimulants. One aspect of the invention relates to the use of an EC 1.1.3 oxidoreductase as an antimicrobial additive for vase water of cut flowers. Another aspect of the invention concerns a method of putting cut flowers into vase water, said method comprising immersing the stems of one or more cut flowers into vase water and adding an antimicrobial composition containing an EC 1.1.3 oxidoreductase to the vase water before, after or at the same time as the cut flowers are immersed into the vase water
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| Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them | 20110033391 | 20110210 |
| This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine+2-oxoglutarate<=>pyruvate+D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid+H2O+acceptor<=>a 2-oxo acid+NH3+reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising... |
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| Biosensor system, sensor chip, and method of measuring analyte concentration in blood sample | 20110027816 | 20110203 |
| The present invention provides a biosensor system that can prevent a measurement error caused by the temperature of the environment in use from occurring. A biosensor system 100 includes a measuring instrument 101 having an operation part 306, and a sensor chip 200 that is insertable into and removable from the measuring instrument 101 and into which a blood sample is introduced. The sensor chip 200 includes a measurement part 41 (a measurement part A) that acquires Data a related to the concentration of an analyte in a blood sample based on the amount of electric current that flows in the blood sample due to a reaction in which an oxidoreductase with the analyte used as a substrate is involved, and a measurement part 42 (a... |
| Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using | 20110020882 | 20110127 |
| The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.
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| Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol | 20110008858 | 20110113 |
| A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.
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| Multimeric oxidoreductases | 20110003353 | 20110106 |
| The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
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| Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol | 20110008858 | 20110113 |
| A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.
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| Multimeric oxidoreductases | 20110003353 | 20110106 |
| The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
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| Organisms for the production of 1,3-butanediol | 20100330635 | 20101230 |
| A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase... |
| Electrode, enzyme sensor using the electrode, fuel battery, electronic device, and method for decomposing polyol | 20100311133 | 20101209 |
| An electrode that can generate reduced coenzymes from a desired substrate in multiple stages is provided. An electrode includes a 2-hydroxycarboxylic acid synthase, a 2-oxo acid synthase, and a 2-oxo acid carboxylyase. The electrode includes a 2-oxo acid carboxylyase, which is a decarboxylase, in addition to a 2-hydroxycarboxylic acid synthase and a 2-oxo acid synthase, which are oxidoreductases; therefore, oxidation products having carboxyl groups, reactions of which do not proceed with oxidoreductases, can be decarboxylated and modified into substances with which oxidoreductases can act. Thus, oxidation reactions and decarboxylation reactions can repeatedly proceed with respect to desired substrates, and large quantities of reduced coenzymes can be generated thereby.
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| Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties | 20100305078 | 20101202 |
| The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods for screening for metallo-oxidoreductase inhibitors, and methods of treating an oxidoreductase related disorder by administering a metallo-oxidoreductase inhibitor to a subject in need of treatment thereof.
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| Oxygen indicator and package | 20100276325 | 20101104 |
| An oxygen indicator using an optical absorption spectral change reaction caused by a substrate in the presence of oxygen via an enzymatic catalysis, which comprises an oxygen sensitive solution containing at least a coloring substrate, an oxidoreductase, and a reducing agent capable of reducing the oxidized coloring substrate.
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| Method of measuring blood component, sensor used in the method, and measuring device | 20100270177 | 20101028 |
| The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The sensor for measuring a component in blood has a first analysis portion and a second analysis portion. The first analysis portion has a first electrode system (11,12) and a reagent layer (14), and the reagent layer (14) has an oxidoreductase that acts on the component and a mediator. In the first analysis portion, the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and... |
| Cruciferous 3h-1,2-dithiole-3-thione (d3t) and methods of protecting against cell injury | 20100261783 | 20101014 |
| Astrocytes possess important roles in maintaining normal brain function and providing trophic support to the neurons. They also suffer a range of toxic insults, being a chief target of prooxidants such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+), 6-hydroxydopamine (6-OHDA), 4-hydroxy-2-nonenal (HNE), and acrolein. Recently, we have observed that the cellular antioxidants and phase 2 enzymes can be upregulated by 3H-1,2-dithiole-3-thione (D3T), a nutraceutical found in cruciferous vegetables, against many prooxidants in human neuroblastoma cell lines (SH-SY5Y). However, the regulation of the above cellular factors by D3T in astrocytes and their role in ameliorating the neurotoxic effects of the above neurotoxins have not been investigated. In this study, we show that incubation of human primary astrocytes with micromolar concentrations (5-100 IM) of D3T for 24 h resulted in... |
| Peg-modified arginine/lysine oxidoreductase | 20100254963 | 20101007 |
| The present invention is directed to an arginine/lysine oxidoreductase modified with polyethylene glycol and to a production method thereof and to methods of treating disorders responsive to a modification of amino acid levels reactive oxygen species and/or ammonium.
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| reagent compositions for use in electrochemical detection | 20100227355 | 20100909 |
| Biological reagent compositions with improved sensitivity to the concentration of blood glucose in patient samples for use in measuring systems and methods. The reagent compositions comprise a glucose oxidoreductase enzyme, a flavin nucleoside coenzyme and a mediator formulation. The mediator formulation comprises at least one electroactive organic molecule and at least one coordination complex.
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| Electron transfer mediator modified enzyme electrode and biofuel cell comprising the same | 20100178572 | 20100715 |
| The present invention provides an electron transfer mediator modified enzyme electrode which can obtain a high current density and exhibit a stable electrode performance by covalently bonding an electron transfer mediator with a surface of a conductive base material constituting the electrode via a specific spacer, and a biofuel cell comprising the electron transfer mediator modified enzyme electrode. An electron transfer mediator modified enzyme electrode comprising a conductive base material connected to an external circuit, an oxidoreductase electron-transferable with the conductive base material and an electron transfer mediator which can mediate electron transfer between the conductive base material and the oxidoreductase, wherein the electron transfer mediator is covalently bonded to the surface of the conductive base material via a spacer containing at least a straight-chain structure,... |
| Oxidoreductases and processes utilising such enzymes | 20100167311 | 20100701 |
| In Cu-containing nitrite reductase from Alcaligenes faecalis S-6 the axial methionine ligand of the type 1 site was replaced (M150G) to make the copper atom accessible to external ligands that might affect the enzyme's catalytic activity. The type-1 site optical spectrum of M150G (A460/A600=0.71) differs significantly from that of the native nitrite reductase (A460/A600=1.3). The reduction potential of the type-1 site of nitrite reductase M150G (EM=312−5 mV versus hydrogen) is higher than that of the native enzyme (EM=213−5 mV). M150G has a lower catalytic activity (kcat=133−6 s−1) than the wild-type nitrite reductase (kcat=416−10−s 1). The binding of external ligands to M150G restores spectral properties, reduction potential (EM<225 mV), and catalytic activity (kcat=374−28 s−1). Also the M150H (A460/A600=7.7, EM=104−5 mV, kcat=0.099−0.006 s−1) and M150T (A460/A600=0.085, EM=340−5 mV,... |
| Method for predicting the response to a therapy | 20100159458 | 20100624 |
| The present invention relates to cancer treatment and particularly to a method for predicting the response of a cancer subject to a given therapy. The invention provides a gene or gene product useful as a predictive marker for classifying the subjects. Also disclosed are diagnostic tools, test kits and compositions and their use in the method. The invention is based on the use of NAD(P)H:Quinone oxidoreductase 1, NQO1, which enables the identification and classification of subjects who would benefit from being excluded from a treatment, particularly from anthracycline-based adjuvant chemotherapy with epirubicin.
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| Recombinant microorganisms having modified production of alcohols and acids | 20100151543 | 20100617 |
| Recombinant acetogenic Clostridia are engineered to modulate production of aliphatic C2-C6 alcohols and aliphatic C2-C6 organic acids from synthetic gases. One aspect of the invention provides a method of producing an aliphatic C2-C6 alcohol using an acetogenic Clostridium micro-organism having at least one genetic modification that reduces or eliminates C2-C6 carboxylic acid production by the modified organism. Another aspect of the invention provides a method of producing an aliphatic C2-C6 alcohol using an acetogenic Clostridium micro-organism having one or more genetic modifications that cause increased enzyme activity of carbon monoxide dehydrogenase, aldehyde ferredoxin oxidoreductase, NADPH-dependent alcohol dehydrogenase, or alcohol dehydrogenase. Yet another aspect of the invention provides a method of producing aliphatic C2-C6 alcohols using acetogenic Clostridium micro-organisms that have been genetically modified to increase C2-C6... |
| Antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme | 20100135926 | 20100603 |
| The present invention relates to an antimicrobial and immunostimulatory system, applications thereof and a process for the production of the antimicrobial and immunostimulatory system. The present invention provides a storage-stable antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme, a substrate for the oxidoreductase enzyme and hydrogen peroxide in an aqueous solution wherein the substrate for the oxidoreductase enzyme is present up to 90% by weight and water is present up to 20% by weight based on the weight of the total composition; the system has a pH from approximately 4 to 8; and the system provides a two-stage hydrogen peroxide release.
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| Fuel cell, using oxidoreductase type enzymes in the cathodic compartment and possibly in the anodic compartment | 20100112414 | 20100506 |
| A proton exchange membrane fuel cell comprises an cathodic compartment including a cathode, an oxidant consisting of oxygen and at least one enzyme catalyst, an anodic compartment comprising an anode, a fuel and at least one catalyst. The anodic and cathodic compartments are arranged at either end of the membrane. The cell is characterized in that the enzyme catalyst of the anodic compartment is an oxidoreductase type enzyme capable of catalyzing the reduction of oxygen into hydrogen peroxide and the hydrogen peroxide is a direct receptor of the electrons from the cathode.
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| Amino acid producing microorganism and a method for producing an amino acid | 20100093044 | 20100415 |
| A microorganism is provided which has an ability to produce an L-amino acid such as L-lysine, L-tryptophan, L-phenylalanine, L-valine, L-leucine, L-isoleucine and L-serine, and has been modified to increase the activity of pyruvate synthase or pyruvate:NADP+ oxidoreductase. This microorganism is cultured in a medium containing ethanol or an aliphatic acid as the carbon source to produce and accumulate the L-amino acid in the medium or cells, and the L-amino acid is collected from the medium or the cells.
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| Novel oxidoreductases and uses thereof | 20100074991 | 20100325 |
| The invention relates to newly identified polynucleotide sequences comprising a gene that encodes a novel oxidoreductase isolated from Aspergillus niger. The invention features the full length nucleotide sequence of the novel gene, the cDNA sequence comprising the full length coding sequence of the novel oxidoreductase as well as the amino acid sequence of the full-length functional protein and functional equivalents thereof. The invention also relates to methods of using these enzymes in baking and in dairy applications. Also included in the invention are cells transformed with a polynucleotide according to the invention and cells wherein a oxidoreductase according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.
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| Detergent composition comprising carbohydrate:acceptor oxidoreductase | 20100056418 | 20100304 |
| The present invention relates to a detergent composition comprising carbohydrate:acceptor oxidoreductase.
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| Biocatalytic hydrophilization of polyolefines | 20100047533 | 20100225 |
| A new process for enhancing the hydrophilicity of the surface of a polyolefin or polyolefin copolymer article is characterized in that the surface is treated with an enzyme selected from oxidoreductases, especially of the cytochrome P450 family or enzymes classified as EC 1.13 or EC 1.14. The process is especially useful for the treatment of polypropylene films, fibres, or fabrics, inter alia for use in sanitary articles, threads, yarns, fabrics, textiles, garments, technical or household articles, printed or dyed cover films or packaging films.
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| Improved method for detecting chemical substances | 20100041089 | 20100218 |
| The present invention provides an assay method for conveniently and easily detecting existence or a quantity of a chemical substance in the environment without relying on expensive measurement devices used in fluorometry. More specifically, the present invention is characterized in that a transformed cell which is transformed by operably linking a polynucleotide encoding oxidoreductase at a downstream of a promoter gene for monitoring whose promoter activity varies with responding to a chemical substance is used.
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| Method of measuring blood component and sensor used in the method | 20090321281 | 20091231 |
| A sensor for blood component analysis that can correct the effect of a hematocrit easily is provided. The sensor includes an analysis portion including a working electrode, a counter electrode, and a reagent portion. The reagent portion includes an oxidoreductase that reacts with the blood component and a mediator, and the blood component is measured by causing a redox reaction between the blood component and the oxidoreductase in the presence of the mediator and detecting a redox current generated by the redox reaction by the working electrode and the counter electrode. In this sensor, the reagent portion further includes a hemolyzing agent (e.g., sodium cholate) for hemolyzing an erythrocyte, and when detecting the redox current, the erythrocyte is hemolyzed with the hemolyzing agent so as to... |
| Oxidoreductases for the stereoselective reduction of keto compounds | 20090311762 | 20091217 |
| The invention relates to a process for the enantioselective enzymatic reduction of a keto compound to the corresponding chiral hydroxy compound, wherein the keto compound is reduced with an oxidoreductase in the presence of a cofactor, and is characterized in that an oxidoreductase is used which has an amino acid sequence in which (a) at least 70% of the amino acids are identical to the amino acids of one of the amino acid sequences SEQ ID No 1, SEQ ID No 6 and SEQ ID No 8, or (b) at least 55% of the amino acids are identical to the amino acids of the amino acid sequence SEQ ID No 2, or (c) at least 65% of the amino acids are identical to the amino acids... |
| Test-sensor production monitoring using xrf spectrometry | 20090310743 | 20091217 |
| A sensor for determining the presence of an analyte in a test sample, said sensor comprising a nanoparticulate membrane comprising nanoparticles of at least one inorganic oxide of an element selected from Group IA, IIA, IIIA, IVA, IB, IIB, IIIB, IVAB, VB, VIB, VIII3 or V11113 of the Periodic Table, and wherein an oxidoreductase and an electrochemical activator are diffusibly dispersed in said nanoparticulate membrane.
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| Topical use of plant extract for skin detoxification | 20090306219 | 20091210 |
| Specific plant extracts are applied topically to upregulate genes which code for proteins to prevent the build-up of and mitigate the activity of various harmful materials within the skin. These upregulated proteins include glutathione transferases, peroxiredoxins, oxidoreductases, glutaredoxins and glutathione syntheses. These proteins produce additional glutathione, glyoxalase I, maintain cellular redox homeostasis, reduce hydrogen peroxide and alkylhydroperoxides, and conjugate glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Keratinocytes have been induced to significantly upregulate glutathione and glyoxalase I protein expression. Additionally, keratinocytes pre-treated with diallyl trisulfide have increased viability when exposed to ozone, UV radiation or cigarette smoke extract. The active material can be extracted from plants such as garlic, onions, shallots, leeks, chives, scallions, brussel sprouts, broccoli, cabbage, cauliflower, bok choy, kale,... |
| Resistance of plants to biotic and abiotic stresses by overexpression of protochlorophyllide oxidoreductase c and its isoforms | 20090291476 | 20091126 |
| A process for the construction of plant transformation vector comprising: digesting a binary vector pCAMBIA 1304 with EcoRI and Sal I; subjecting the digested binary vector to the step of end filling by Klenow; re-ligating the said binary vector by known method; obtaining CaMV 35 8 promoter cassette with Ω enhancer from pSH9; incorporating the said Camv35S promoter cassette into the Hind III site of the said binary vector to obtain modified pCAMBIA 1304 vector; subjecting pore DNA fragment (1206 bp) to the step of amplification using a pair of primers; introducing EcoRI restriction sites to both the primers; ligating the said amplified cDNA fragment to pGEM T-easy; extracting EcoRI digested porC cDNA fragment from cloned pGEM T-easy; inserting said EcoRI digested porC cDNA fragment into... |
| Process for the enantioselective reduction and oxidation, respectively, of steroids | 20090280525 | 20091112 |
| c) an additional oxidoreductase/alcohol dehydrogenase is used for the oxidation of the secondary alcohol of general formula RXRYCHOH or of the cycloalkanol, respectively.
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| Process for the enantioselective reduction and oxidation, respectively, of steroids | 20090280525 | 20091112 |
| c) an additional oxidoreductase/alcohol dehydrogenase is used for the oxidation of the secondary alcohol of general formula RXRYCHOH or of the cycloalkanol, respectively.
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| Ehrlichia disulfide bond formation proteins and uses thereof | 20090275102 | 20091105 |
| Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the E. chaffeensis and E. canis Dsb proteins are at most only 31% or less homologous to other known Dsb proteins, the Ehrlichia Dsbs contain a cysteine active site, Cys-Gly-Tyr-Cys, similar to those in known Dsb proteins. As predicted by 15-amino acid identical N-terminal signal peptides, the proteins are primarily localized in the periplasm of E. chaffeensis and E. canis, possibly playing a role in antigenicity and pathogenesis. The present invention provides the nucleotide and amino acid sequences and expression vectors for the E. chaffeensis and E. canis dsb genes, antisera directed against the proteins, and kits to determine whether an individual or animal... |
| Ehrlichia disulfide bond formation proteins and uses thereof | 20090275102 | 20091105 |
| Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the E. chaffeensis and E. canis Dsb proteins are at most only 31% or less homologous to other known Dsb proteins, the Ehrlichia Dsbs contain a cysteine active site, Cys-Gly-Tyr-Cys, similar to those in known Dsb proteins. As predicted by 15-amino acid identical N-terminal signal peptides, the proteins are primarily localized in the periplasm of E. chaffeensis and E. canis, possibly playing a role in antigenicity and pathogenesis. The present invention provides the nucleotide and amino acid sequences and expression vectors for the E. chaffeensis and E. canis dsb genes, antisera directed against the proteins, and kits to determine whether an individual or animal... |
| Lactic acid-producing yeast cells having nonfunctional l- or d-lactate:ferricytochrome c oxidoreductase cells | 20090253189 | 20091008 |
| Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced I, or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
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| Process for the biological production of 1,3-propanediol with high titer | 20090253192 | 20091008 |
| The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanediol is achieved by the use of an E. coli transformed with the Klebsiella pneumoniae dha regulon genes dhaR, orfY, dhaT, orfX, orfW, dhaB1, dhaB2, dhaB3, and orfZ, all these genes arranged in the same genetic organization as found in wild type Klebsiella pneumoniae. In another aspect of the present invention, an improved process for the production of 1,3-propanediol from glucose using a recombinant E. coli containing genes encoding a G3PDH, a G3P phosphatase, a dehydratase, and a dehydratase reactivation factor compared to an identical process using a... |
| Lactic acid-producing yeast cells having nonfunctional l- or d-lactate:ferricytochrome c oxidoreductase cells | 20090253189 | 20091008 |
| Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced I, or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
... |
| Process for the biological production of 1,3-propanediol with high titer | 20090253192 | 20091008 |
| The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanediol is achieved by the use of an E. coli transformed with the Klebsiella pneumoniae dha regulon genes dhaR, orfY, dhaT, orfX, orfW, dhaB1, dhaB2, dhaB3, and orfZ, all these genes arranged in the same genetic organization as found in wild type Klebsiella pneumoniae. In another aspect of the present invention, an improved process for the production of 1,3-propanediol from glucose using a recombinant E. coli containing genes encoding a G3PDH, a G3P phosphatase, a dehydratase, and a dehydratase reactivation factor compared to an identical process using a... |
| Food ingredients and food products treated with an oxidoreductase and methods for preparing such food ingredients and food products | 20090238917 | 20090924 |
| A method of making an aldobionate product is described. The method may include providing a milk product having one or more reducing sugars, and maintaining a pH of the milk product at about 5.5 or more by adding a buffer compound to the milk product. The method may also include adding an oxidoreductase enzyme to the milk product, where at least a portion of the reducing sugar is oxidized into the aldobionate product. In addition, a method of making an aldobionate product is described that includes the steps of providing a milk product comprising a reducing sugar, mixing oxygen into the milk product, and adding an oxidoreductase enzyme to the milk product, where at least a portion of the reducing sugar is oxidized into the aldobionate... |
| Colorimetric method and reagent used for the same | 20090233322 | 20090917 |
| The present invention provides a colorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring reagent that produces color by reduction via a mediator by using an oxidoreductase; and performing qualitative or quantitative analysis of the analyte by measuring color produced in the coloring reagent. The enzyme reaction of this method is a single stage reaction, and the color production reaction occurs via the mediator. Therefore, the measurement can be performed in a short time. Since this reaction requires neither hydrogen peroxide nor oxygen, the measured values are highly reliable.
... |
| Colorimetric method and reagent used for the same | 20090233322 | 20090917 |
| The present invention provides a colorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring reagent that produces color by reduction via a mediator by using an oxidoreductase; and performing qualitative or quantitative analysis of the analyte by measuring color produced in the coloring reagent. The enzyme reaction of this method is a single stage reaction, and the color production reaction occurs via the mediator. Therefore, the measurement can be performed in a short time. Since this reaction requires neither hydrogen peroxide nor oxygen, the measured values are highly reliable.
... |
| Reagents for the detection of protein phosphorylation in leukemia signaling pathways | 20090220991 | 20090903 |
| The invention discloses nearly 480 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, acetyltransferases, actin binding proteins, adhesion proteins, apoptosis proteins, calcium-binding proteins, cell cycle regulation proteins, cell surface proteins, channel proteins, chaperone proteins, contractile proteins, cytokine proteins, cytoskeletal proteins, G protein regulators and GTPase activating proteins, guanine nucleotide exchange factors, helicase proteins, immunoglobulin superfamily proteins, inhibitor proteins, protein kinases, lipid kinases, ligases, lipid binding proteins, methytransferases, motor proteins, oxidoreductases, phosphotases, phosphodiesterases, phospholipases,... |
| Process for the enantioselective enzymatic reduction of hydroxy keto compounds | 20090221044 | 20090903 |
| c) the reduction of the hydroxy ketone and the oxidation of the secondary alcohol are catalyzed by the same oxidoreductase.
... |
| Method for controlling nad(p)/nad(p)h ratio by oxidoreductase | 20090215145 | 20090827 |
| Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
... |
| Method for controlling nad(p)/nad(p)h ratio by oxidoreductase | 20090215145 | 20090827 |
| Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
... |
| Method for controlling nad(p)/nad(p)h ratio by oxidoreductase | 20090215145 | 20090827 |
| Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
... |
| Method for controlling nad(p)/nad(p)h ratio by oxidoreductase | 20090215145 | 20090827 |
| Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
... |
| Method for controlling nad(p)/nad(p)h ratio by oxidoreductase | 20090215145 | 20090827 |
| Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
... |
| Reagent compositions for use in electrochemical detection | 20090186372 | 20090723 |
| Biological reagent compositions with improved sensitivity to the concentration of blood glucose in patient samples for use in measuring systems and methods. The reagent compositions comprise a glucose oxidoreductase enzyme, a flavin nucleoside coenzyme and a mediator formulation. The mediator formulation comprises at least one electroactive organic molecule and at least one coordination complex.
... |
| Bladder cancer treatment and methods | 20090163570 | 20090625 |
| Disclosed herein are various bladder cancer treatments and methods. The present disclosure can take advantage of propylene glycol concentrations and/or NAD(P)H:quinone oxidoreductase-1 (NQO1), Cytochrome P450 Oxidoreductase (P450R) and Glucose transporter 1 (Glut-1) protein expression in human transitional cell carcinoma of the bladder to offer individually targeted bladder cancer treatments.
... |
| Bladder cancer treatment and methods | 20090163570 | 20090625 |
| Disclosed herein are various bladder cancer treatments and methods. The present disclosure can take advantage of propylene glycol concentrations and/or NAD(P)H:quinone oxidoreductase-1 (NQO1), Cytochrome P450 Oxidoreductase (P450R) and Glucose transporter 1 (Glut-1) protein expression in human transitional cell carcinoma of the bladder to offer individually targeted bladder cancer treatments.
... |
| Electrochemical system and method thereof | 20090152129 | 20090618 |
| An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10−21 M). In embodiments, the invention provides a cyclic voltammetry system comprising a working electrode, an oxidoreductase, and an electric field generator, wherein the oxidoreductase is immobilized on the working electrode; and the electric field generator generates an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by that the electrical field enhances quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between... |
| Method for producing chiral alcohols | 20090148917 | 20090611 |
| The invention relates to a method for producing an enantiopure alcohol of general formula (Ia) or (Ib), wherein R1, R2, R3, R4, R5 and R6 each represent hydrogen, halogen, a C1-C6 alkyl or C1-C6 alkoxy group, with the proviso that at least one of the groups R1, R2, R3, R4, R5 and R6 is different from the remaining five groups and with the additional proviso that at least one of the groups R1, R2, R3, R4, R5 and R6 is a halogen. The invention is characterized in that a ketone of general formula (II), wherein R1, R2, R3, R4, R5 and R6 are defined as above, is enzymatically reduced in the presence of an S-specific or R-specific dehydrogenase/oxidoreductase using NADH or NADPH as the cofactor.
... |
| Methods for producing a vegetable product | 20090142445 | 20090604 |
| The present invention relates to methods for producing vacuum packed pre-boiled vegetable products as well as to for packaging a vegetable product. TIhe invention further relates to vacuum packed pre-boiled vegetable products obtained by the methods of the present invention, wherein an effective amount of an oxidoreductase enzyme composition is added to the vegetable product.
... |
| Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors | 20090124623 | 20090514 |
| The present invention relates to methods of preserving or increasing renal function in a subject in need thereof by administering a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting compound or salt thereof. The present invention also relates to methods of increasing renal function in a subject in need thereof by administering a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting compound or salt thereof.
... |
| Engineered microorganisms for increasing product yield in biotransformations, related methods and systems | 20080293101 | 20081127 |
| There are disclosed recombinant microorganisms engineered to increase product yield in a biotransformation. In an embodiment, the microorganisms are engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. There are also disclosed methods and systems for using recombinant microorganisms engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. Other embodiments are also disclosed.
... |
| Multimeric oxidoreductases | 20080293124 | 20081127 |
| The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
... |
| Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production | 20080286870 | 20081120 |
| A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism. It also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
... |
| Methods for preserving renal function using xanthine oxidoreductase inhibitors | 20080269226 | 20081030 |
| The present invention relates to methods of preserving renal function in a subject in need thereof by administering a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting compound or salt thereof.
... |
| 2031 oxidoreductase | 20080206220 | 20080828 |
| and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), (v) or (vi), wherein binding or modulation of (i), (ii), (iii), (iv), (v) or (vi) indicates that the candidate substance is an anti-fungal agent.
... |
| Novel mycobacterium tuberculosis protein composition | 20080199869 | 20080821 |
| Mycobacterium tuberculosis proteins and protein compositions that are components of a desaturase complex are provided. The Mycobacterium tuberculosis desaturase complex may include a desaturase and an oxidoreductase. The complex may include the rv3229c and rv3230c gene products of Mycobacterium tuberculosis. Vectors for expressing the desaturase and the oxidoreductase can be packaged together, including a label that indicates their use as a complex for analyzing desaturation of fatty acids. In addition, methods for screening target ligands specific for a desaturase complex are also provided.
... |
| Ethanol production using xylitol synthesis mutant of xylose-utilizing zymomonas | 20080187973 | 20080807 |
| Production of ethanol using a strain of xylose-utilizing Zymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.
... |
| Expression systems for mammalian and mycobacterial desaturases | 20080182249 | 20080731 |
| Expression system for components of a desaturase complex is provided. The system includes expression of a desaturase and an oxidoreductase. The system may be used for expression of mycobacterial desaturases or for expression of mammalian desaturases. The system may further include cell-free expression of other components of the desaturase complex. The expression system may include expression of stearoyl-CoA. The expression system may further include expression of cytochrome b5. The expression system may also include expression of cytochrome b5 reductase. The expression system may also include expression of Rv3230c. In addition, methods for assaying the activity of a stearoyl-CoA desaturase in vitro are provided.
... |
| Method for the enantioselective enzymatic reduction of keto compounds | 20080153140 | 20080626 |
| The present invention relates to a process for the enantioselective enzymatic reduction of keto compounds, in particular of 4-halo-3-oxobutyric acid esters, to the corresponding R-alcohols or S-4-halo-3-hydroxybutyric acid esters, respectively, using an R-specific oxidoreductase in the presence of a cofactor.
... |
| Oxidative, reductive, hydrolytic and other enzymatic systems for oxidizing, reducing, coating, coupling or cross-linking natural and artificial fiber materials, plastic materials or other natural or artificial monomer to polymer materials | 20080070284 | 20080320 |
| The invention relates to methods for oxidizing (redox reactions, preferably pulp delignification/bleaching), for carrying out coupling reactions (grafting polymer materials) or for carrying out cross-linking reactions on natural (i.e. having natural origin) or artificial (i.e. synthetically produced polymers) monomers to polymers or of mixtures of natural and artificial polymers or of fibre materials, of lignocellulose-containing, cellulose-containing or protein-like natural polymers or fibre materials such as pulp, textiles like cotton and wool. The invention is characterized in that 1) these oxidation, coupling or cross-linking reactions are carrying out using hydrolases such as lipases, esterases, proteases, amidases, transferases, acylases, glycosidases or glycotransferases or oxidoreductases, such as preferably peroxidases, chloroperoxidases and laccases, either individually or in combination with one another; and 2) that these reactions ( oxidation, coupling or... |
| Electrode compositions and configurations for electrochemical bioreactor systems | 20070298472 | 20071227 |
| Electrodes and configurations for electrochemical bioreactor systems that can use electrical energy as a source of reducing power in fermentation or enzymatic reactions and that can use electron mediators and a biocatalyst, such as cells or enzymes, to produce electricity are disclosed. Example electrodes in the system may comprise: (1) neutral red covalently bound to graphite felt; (2) a carboxylated cellulose bound to the graphite felt, neutral red bound to the carboxylated cellulose, NAD+ bound to the graphite felt, and an oxidoreductase (e.g., fumarate reductase) bound to the graphite felt; or (3) a metal ion electron mediator bound to graphite. Various biocatalysts, such as an oxidoreductase, cells of Actinobacillus succinogenes, cells of Escherichia coli, and sewage sludge, are suitable for use in the electrochemical bioreactor system.
... |
| Fungicidal compositions based on pyridylmethylbenzamide derivatives and at least one complex iii inhibiting compound | 20070293549 | 20071220 |
| 1) Fungicidal compositions comprising: a) at least one pyridylmethylbenzamide derivative of Formula (I), in which the various radicals are as defined in the description; and b) at least one compound (II) capable of inhibiting the transport of electrons of the respiratory chain of mitochondrial ubiquinol:ferricytochrome-c oxidoreductase or complex III in phytopathogenic fungal organisms. 2) Process for curatively or preventively controlling the phytopathogenic fungi of crops, characterized in that an effective and nonphytotoxic quantity of one of these fungicidal compositions is applied to the aerial parts of plants.
... |
| Method and device for detection of nucleic acids and/or polypetides | 20070248964 | 20071025 |
| A method for the detection and/or quantification of at least one target nucleic acid or target polypeptide in a sample of nucleic acids or polypeptides comprising the steps of: a) providing a sample comprising nucleic acids or polypeptides; b) labeling the nucleic acids or polypeptides with a ligand conjugate, the ligand conjugate comprising a first element binding to the nucleic acids or polypeptides and a second element which is a capture ligand; c) contacting the nucleic acid-ligand conjugates or polypeptide-ligand conjugates with at least one capture probe, the capture probe hybridising with or binding to at least one target nucleic acid or target polypeptide; d) adding i) an oxidoreductase enzyme, wherein the oxidoreductase enzyme is recognised by the capture ligand, or ii) a complex comprising an... |
| Oxidoreductase from pichia capsulata | 20070243594 | 20071018 |
| The invention relates to a NADH-dependent oxidoreductase obtained from yeasts, for example, of the genus Pichia, more particularly from Pichia capsulata. The oxidoreductace used in an enzymatic process for enantioselective reduction of organic ketocompounds to the corresponding (S)-hydroxy compounds and in an enzymnatic process for anantioselective preparation of (S)-hydroxy compounds in a two phase system using the isolated, recombinantly overexpressed oxidoreductacse from Pichia capsulata.
... |
| Methods of modulating inflammatory reactions by modulating xanthine oxidoreductase activity | 20070224287 | 20070927 |
| Evidence is presented that inflammation and injury involves activation of xanthine oxidoreductase (XOR) in the newly recruited mononuclear phagocytes (MNP). XOR has been shown to be increased predominantly in the MNP that increase rapidly in the lungs of rats that develop acute lung injury (ALI) following intratracheal cytokine insufflation. XOR was recovered from the MNP largely converted to its oxygen radical generating, reversible O-form, and alveolar MNP exhibited increased oxidative stress as evidenced by increased nitrotyrosine staining. Cytokine insufflation also increased alveolar cell apoptosis. A functional role for XOR in cytokine induced inflammation was demonstrated. Tungsten and allopurinol decreased MNP XOR induction, nitrotyrosine staining, inflammatory cell infiltration, and alveolar cell apoptosis. Transfer of control or allopurinol treated MNP into rat lungs and confirmed a specific role... |
| Method for the enzymatic production of chiral alcohols | 20070212766 | 20070913 |
| R1 and R2 being different and each being an organic radical, an oxidoreductase and a co-substrate is reacted to form a chiral secondary alcohol with the adsorbent being associated with the oxidoreductase. The adsorbent associated with the oxidorecutase is separated off from the biotransformation composition after completion of the reaction.
... |
| Production of (s)-2-butanol by oxidative racemate resolution | 20070207529 | 20070906 |
| A method for producing (S)-2-butanol of an optical purity ee of >90% comprises reacting a biotransformation composition comprising, as starting materials, a racemic mixture of 2-butanol (rac-2-butanol), an oxidoreductase, a redox cofactor and a cosubstrate, (R)-2-butanol being selectively oxidized to 2-butanone, and (S)-2-butanol being retained in an optical purity ee of >90%.
... |
| Bladder cancer treatment and methods | 20070203112 | 20070830 |
| Disclosed herein are various bladder cancer treatments and methods. The present disclosure can take advantage of propylene glycol concentrations and/or NAD(P)H:quinone oxidoreductase-1 (NQO1), Cytochrome P450 Oxidoreductase (P450R) and Glucose transporter 1 (Glut-1) protein expression in human transitional cell carcinoma of the bladder to offer individually targeted bladder cancer treatments.
... |
| Skin dressings | 20070190122 | 20070816 |
| A skin dressing of the general form disclosed in WO 03/030800 comprises oxidoreductase enzyme in hydrated condition in a hydrated hydrogel of hydrophilic polymer material, wherein hydrogel comprises at least 25% by weight of the polymer material. A currently preferred dressing comprises a lower, skin-contacting layer (18) comprising a hydrated hydrogel comprising 30% by weight sodium poly-AMPS and 5% by weight glucose, and an upper layer (16) comprising a hydrated hydrogel comprising 15% by weight sodium poly-AMPS, 15% by weight ammonium poly-AMPS, and glucose oxidase. Using hydrogels with a higher concentration of polymer material is found to affect the rate of oxygen generation and hence the oxygen concentration profile beneath the dressing in use in a manner beneficial to wound healing.
... |
| Bladder cancer treatment and methods | 20070185188 | 20070809 |
| Disclosed herein are various bladder cancer treatments and methods. The present disclosure can take advantage of propylene glycol concentrations and/or NAD(P)H:quinone oxidoreductase-1 (NQO1), Cytochrome P450 Oxidoreductase (P450R) and Glucose transporter 1 (Glut-1) protein expression in human transitional cell carcinoma of the bladder to offer individually targeted bladder cancer treatments.
... |
| Methods for treating hypertension | 20070167454 | 20070719 |
| The present invention relates to methods of treating subjects suffering from pre-hypertension or hypertension by administering to a subject in need of treatment thereof a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting compound or salt thereof.
... |
| Process for producting 1,3-propanediol and or/3-hydroxypropionic acid | 20070148749 | 20070628 |
| This invention is intended to improve the efficiency of producing 1,3-propanediol from glycerol and to provide an industrially effective process for producing the same. Such process involves the use of a transformant comprising the gene encoding the large subunit of glycerol dehydratase and/or diol dehydratase, the gene encoding the medium subunit thereof, and the gene encoding the small subunit thereof, the gene encoding the large subunit of the reactivation factor for glycerol dehydratase and/or the reactivation factor for diol dehydratase and the gene encoding the small subunit thereof, the gene encoding aldehyde dehydrogenase, and the gene encoding 1,3-propanediol oxidoreductase and/or the gene encoding propanol dehydrogenase.
... |
| Sirna mediated post-transriptional gene silencing of genes involved in alopecia | 20070141009 | 20070621 |
| Compositions and methods for the use of inhibitory nucleic acids, for example small inhibitory ribonucleic acids (siRNA), to adjust, manipulate, prevent, inhibit, interfere, or block the androgen signal transduction pathway in a host cell, for example in a host's hair cell are provided. Aspects of the disclosure provide compositions and methods for interfering with the androgen signal transduction pathway by down regulating the expression of proteins involved in the androgen signal transduction pathway. Exemplary gene targets encoding proteins involved in the androgen signal transduction pathway include but are not limited to isozymes I and II of 5-α reductase, the androgen receptor, aromatase, 3-α-hydroxysteroiddehydrogenase, 3-β-hydroxysteroiddehydrogenase , 3-β-hydroxysteroiddehydrogenase-4-5-isomerase, 17-β-hydroxysteroidoxidoreductase, and steroid sulfatase. In some aspects, the inhibitory nucleic acids, for example siRNAs, interfere with the expression of targeted... |
| Method of preventing discoloration of dough, dough compositions, and dough products | 20070141201 | 20070621 |
| Described are dough compositions, dough products, and related methods for preventing discoloration of dough compositions, including particular embodiments involving a packaged dough product suitable for storage under low pressure conditions, and embodiments wherein the dough comprises an oxidoreductase enzyme such as glucose oxidase, and optionally catalase.
... |
| Alleles of the mqo gene from coryneform bacteria | 20070141680 | 20070621 |
| The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
... |
| Method of measuring blood component, sensor used in the method, and measuring device | 20070131565 | 20070614 |
| The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The sensor for measuring a component in blood has a first analysis portion and a second analysis portion. The first analysis portion has a first electrode system (11,12) and a reagent layer (14), and the reagent layer (14) has an oxidoreductase that acts on the component and a mediator. In the first analysis portion, the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and... |
| Inactivated enzyme variants and associated process and reagent system | 20070087398 | 20070419 |
| The present invention relates to oxidoreductase apoenzyme variants which are enzymaticaily inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA sequences and the use of these oxidoreductase apoenzyme variants in diagnostic applications.
... |
| Enzymatic electrochemical biosensor | 20070080073 | 20070412 |
| An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof.
... |
| Composition for the treatment of bad breath | 20070081952 | 20070412 |
| A composition suitable for treating bad breath and including a carrier material, at least one enzyme sulphite oxidase, an enzyme for breaking down the starch and/or cellulose present in the oral cavity to give glucose, an enzyme oxidoreductase, a source of halogen or pseudohalogen ions, and an enzyme peroxidase.
... |
| Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways | 20070072235 | 20070329 |
| The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein Kinases (including Receptor Tyrosine Kinases), Adaptor/Scaffold Proteins, Cellular Metabolism or Miscellaneous Enzymes, Oxidoreductases, Transcription Factors, Cytoskeletal Proteins, Translation Initiation Complexes, RNA Binding Proteins, Proteases, Acetyltransferases, G protein regulators/GTPases, Helicases, Apoptosis/Cell Cycle Regulation proteins, and Hydrolases.
... |
| Reagents for the detection of protein phosphorylation in t-cell receptor signaling pathways | 20070059845 | 20070315 |
| The invention discloses 95 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of the T-cell receptor, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Adhesion proteins, Calcium-binding proteins, Cell Cycle Regulation or Channel proteins, Chaperones, Cofactor proteins, Cytoskeletal proteins, DNA Binding proteins, G protein or GTPase Activating proteins, Ligases, Lipid Kinases and Binding proteins, Oxidoreductases, Protein Kinases, Protein Phosphatases, Receptor proteins, RNA Binding proteins, Transcription Factor/Initiation Complex proteins, Transcription Coactivator/Corepressor proteins, Translation Initiation Complex proteins, Ubitquitin Conjugating System proteins, and Vesicle... |
| Method for the enzymatic production of chiral 1-acylated 1,2-diols | 20070042475 | 20070222 |
| an oxidoreductase, a redox cofactor and a cosubstrate are reacted forming the chiral compound of the formula (I) which is subsequently isolated.
... |
| Biosensor | 20070042377 | 20070222 |
| A sensor for determining the presence of an analyte in a test sample, said sensor comprising a nanoparticulate membrane comprising nanoparticles of at least one inorganic oxide of an element selected from Group IA, IIA, IIIA, IVA, IB, IIB, IIIB, IVAB, VB, VIB, VIII3 or VIIII3 of the Periodic Table, and wherein an oxidoreductase and an electrochemical activator are diffusibly dispersed in said nanoparticulate membrane.
... |
| Biosensor and method for producing the same | 20070034512 | 20070215 |
| The present invention provides a biosensor that can prevent a mediator from being affected by oxygen, thereby allowing an analyte in a sample solution to be measured rapidly and easily with high accuracy. The biosensor can be produced by providing a substrate having electrodes, applying a solvent containing a mediator, a surfactant, a buffer, and a layered inorganic compound to surfaces of the electrodes to form an inorganic gel layer for preventing natural oxidation of the mediator, and forming an enzyme reagent layer containing an oxidoreductase on the inorganic gel layer. In this biosensor, due to the inorganic gel layer, the mediator having been reduced by the reaction between an analyte and the oxidoreductase can be measured electrochemically, without being reoxidized by dissolved oxygen or the... |
| Method for producing a soy protein product | 20070031577 | 20070208 |
| The present invention relates to a method for producing a soy protein product by treatment of soy protein with at least one oxidoreductase.
... |
| Process for biochemical production of glyoxylic acid | 20070026510 | 20070201 |
| The present invention provides an industrially advantageous process for biochemical production of glyoxylic acid from glyoxal. More specifically, the present invention provides a process for production of glyoxylic acid, which is characterized in that the process comprises allowing oxidoreductase that can convert glyoxal into glyoxylic acid, such as oxidase and dehydrogenase, to act on glyoxal, so as to convert glyoxal into glyoxylic acid.
... |
| Pyridine nucleotide dehydrogenase based biosensor electrodes | 20070009983 | 20070111 |
| The invention provides an electrode for the electrochemically reversible interconversion of the oxidised and reduced versions of a pyridine nucleotide comprising: an electrically conducting surface; an isolated pyridine nucleotide dehydrogenase module of an enzyme; wherein said isolated pyridine nucleotide dehydrogenase module is applied to the electrically conducting surface. The isolated pyridine nucleotide dehydrogenase module may be the Iλ subcomplex of bovine mitochondrial NADH: ubiquinone oxidoreductase. Electrochemical cells comprising these electrodes are also provided by the invention.
... |
| Skin dressings containing oxidoreductase enzyme | 20060275350 | 20061207 |
| A skin dressing comprises a first dressing component (16) carrying oxidoreductase enzyme in dried condition; and a second dressing component (18) carrying a source of water, such that when the first and second dressing components are placed in fluid communication with each other, water migrates from the second component towards the first comportent and acts to hydrate enzyme carried by the first component, at least at the surface of the first component. The dressing components are kept separate before use, e.g. being sealed in separate sterile, water-impervious packages such as laminated aluminium foil pouches. In use of the dressing, the second dressing component is located on the skin of a human or animal, e.g. over a wound to be treated or on a region of skin... |
| Antitumor agents | 20060251640 | 20061109 |
| An antitumor agent, which is a combination of an oxidoreductase, such as xanthine oxidase chemically conjugated to a polymer such as poly ethylene glycol, for initial administration and accumulation in the tumor tissue followed by administration and of a substrate for the oxidoreductase which releases reactive oxygen species. Improved tumor selective cytotoxic activity results.
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| Methods for treating nephrolithiasis | 20060252808 | 20061109 |
| The present invention relates to methods of treating subjects suffering from nephrolithiasis by administering to a subject in need of treatment thereof a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting compound or salt thereof.
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| Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme b12 synthesis | 20060246562 | 20061102 |
| Recombinant organisms are provided comprising genes encoding cob(II)alamin reductase, cob(I)alamin adenosyltransferase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for the production of 1,3-propanediol from a variety of carbon substrates.
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| Method of scavenging intermediate formed by reaction of oxidoreductase with substrate | 20060235558 | 20061019 |
| A process system 1 comprises a process apparatus 10 which performs a predetermined process on a wafer W, a plurality of detection means which detect statuses in the process apparatus 10, an abnormality detection section 15 which detects an abnormality in detection information from the plurality of detection means, an alarm generation section 16 which generates an alarm when the abnormality detection section 15 detects an abnormality, an information storage section 17 which stores the detection information from the detection means in the process apparatus 10 and alarm information as a process history of the process apparatus 10, an alarm-related information acquisition section 18 which selectively acquires information relating to an alarm selected from the information storage section 17, and a display section 21 which displays... |
| [1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-s-transferase and nadph quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular | 20060194846 | 20060831 |
| wherein wherein the symbols have the meanings given in the specification.
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| Medium containing water with increased viscosity, method for production and use thereof | 20060165802 | 20060727 |
| The invention concerns a water-containing medium with an increased viscosity containing a gellable polymer component with phenolic substituents modified with the aid of oxidases, characterized in that it was modified by a) a protein with polyphenol oxidase activity and/or b) an enzyme mixture containing hydrolases, oxidoreductases and peroxidases. The medium modified in this manner can be a gel that is preferably in a (partially) dried or (partially) rehydrated state, whose viscosity or gel strength can be selectively adjusted and which, even after a drying process and rehydration, again stably attains the original viscosity or gel strength. In addition the water-containing medium does not have any by-products that could have an adverse effect on quality of the gel or its sensory properties. In addition to the water-containing... |
| Alleles of the mqo gene from coryneform bacteria | 20060166338 | 20060727 |
| The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
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| Process for the biological production of 1,3-propanediol with high titer | 20060148053 | 20060706 |
| The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanediol is achieved by the use of an E. coli transformed with the Klebsiella pneumoniae dha regulon genes dhaR, orfY, dhaT, orfX, orfW, dhaB1, dhaB2, dhaB3, and orfZ, all these genes arranged in the same genetic organization as found in wild type Klebsiella pneumoniae. In another aspect of the present invention, an improved process for the production of 1,3-propanediol from glucose using a recombinant E. coli containing genes encoding a G3PDH, a G3P phosphatase, a dehydratase, and a dehydratase reactivation factor compared to an identical process using a... |
| Process for the biological production of 1,3-propanediol with high titer | 20060121588 | 20060608 |
| The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanediol is achieved by the use of an E. coli transformed with the Klebsiella pneumoniae dha regulon genes dhaR, orfY, dhaT, orfX, orfW, dhaB1, dhaB2, dhaB3, and orfZ, all these genes arranged in the same genetic organization as found in wild type Klebsiella pneumoniae. In another aspect of the present invention, an improved process for the production of 1,3-propanediol from glucose using a recombinant E. coli containing genes encoding a G3PDH, a G3P phosphatase, a dehydratase, and a dehydratase reactivation factor compared to an identical process using a... |
| Method of improving the hydration of pasta and preparation of pasta products | 20060115567 | 20060601 |
| A method of improving the hydration of pasta or pasta products, comprising adding to the pasta or to pasta dough or to pasta dough ingredients an effective amount of an oxidoreductase which is at least capable of oxidizing a carbohydrate. Preferably the oxidoreductase is at least capable of oxidizing maltose.
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| Inactivated enzyme variants and associated process and reagent system | 20060094099 | 20060504 |
| The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA sequences and the use of these oxidoreductase apoenzyme variants in diagnostic applications.
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| Oxidizing composition and uses for dyeing, for permanently reshaping or for bleaching keratin fibres | 20060080789 | 20060420 |
| The present application relates to a cosmetic composition intended for treating keratin fibres, comprising, in a support which is suitable for keratin fibres: (a) at least one enzyme of 2-electron oxidoreductase type in the presence of at least one donor for the said enzyme;(b) at least one aminosilicone; as well as to processes for treating keratin fibres, in particular processes for dyeing, permanently reshaping or bleaching the hair, using this composition.
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