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Osteoporosis

Osteoporosis-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Llp2a-bisphosphonate conjugates for osteoporosis treatment
The Regents Of The University Of California
June 22, 2017 - N°20170174722

The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e. G. Llp2a, conjugated with a bisphosphonate drug, e. G. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α4β1 integrin on mesenchymal ...
Protease inhibitors
The Regents Of The University Of California
June 15, 2017 - N°20170166538

Or a pharmaceutically acceptable salt, n-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin k, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases:
Novel therapeutic uses of benzylideneguanidine derivatives for the treatment of proteopathies
Inflectis Bioscience
June 01, 2017 - N°20170151196

The present invention relates to novel uses of a compound of formula (i), or a tautomer and/or a pharmaceutically acceptable salt thereof, in treating a disorder associated with the ppp1r15a pathway and associated with protein misfolding stress and in particular with accumulation of misfolded proteins selected in the group of tauopathies, synucleinopathies, polyglutamine and polyalanine diseases, leukodystrophies, ...
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Triphenylethylene compounds and uses thereof
Inflectis Bioscience
May 25, 2017 - N°20170144975

Triphenylethylene compounds as dual aromatase inhibitors and selective estrogen receptors modulators are described. Also described are methods for treating patients of breast cancers, and patients of breast cancer comorbid with osteoporosis, using the described triphenylethylence compounds or pharmaceutical formulations thereof.
Calcitonin mimetics for treating diseases and disorders
Inflectis Bioscience
May 25, 2017 - N°20170143800

Calcitonin mimetic peptides having an amino acid sequence in accordance with seq id no:8 or seq id no:53, each of which may be carboxylated at its n-terminal or otherwise modified to reduce the positive charge of the first amino acid and independently of that may be amidated at its c-terminal, and in each of which the 1 and 7 position cysteine residues ...
Compositions and methods for the diagnosis and treatment of bone fractures and disorders
Universität Für Bodenkultur Wien
May 11, 2017 - N°20170130268

The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected micro rnas in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy individuals is indicative of the disorder.
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Calcium carbonate composition for ameliorating, preventing and treating osteoporosis, and manufacturing method therefor
Medience Co., Ltd.
May 04, 2017 - N°20170119815

The present invention relates to a calcium carbonate composition for ameliorating, preventing and treating osteoporosis, and a manufacturing method therefor. More specifically, the present invention relates to a calcium carbonate composition for alleviating, preventing and treating osteoporosis, the composition comprising calcium, magnesium and zinc, and having calcium carbonate microparticles formed by the supply of carbon dioxide gas. The present invention ...
Therapeutic agents for reducing parathyroid hormone levels
Kai Pharmaceuticals, Inc.
April 27, 2017 - N°20170114095

Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, x1-x2-x3-x4-x5-x6-x7, wherein the x1 subunit comprises a thiol-containing moiety and the distribution of charge on the x2-x7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, ...
Urea compounds and their use as enzyme inhibitors
Kai Pharmaceuticals, Inc.
April 13, 2017 - N°20170101381

Or a pharmaceutically acceptable salt or derivative thereof. The compound may be used in the treatment or prevention of a disorder selected from appetite regulation, obesity, metabolic disorders, cachexia, anorexia, pain, inflammation, neurotoxicity, neurotrauma, stroke, multiple sclerosis, spinal cord injury, parkinson's disease, levodopa-induced dyskinesia, huntington's disease, gilles de la tourette's syndrome, tardive dyskinesia, dystonia, amyotrophic lateral sclerosis, alzheimer's disease, epilepsy, ...
Fibronectin based scaffold domain proteins that bind to myostatin
Bristol-myers Squibb Company
March 30, 2017 - N°20170088602

The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or ...
Use of peptidic drugs for osteoporosis treatment and bone regeneration
Universidad Nacional Autonoma De Mexico
March 30, 2017 - N°20170088584

The present invention provides osteogenic peptides derived from the cementum-derived attachment protein (hacd1/cap) and another derived from the cementum protein 1 (cemp1) and pharmaceutical compositions of these peptides for the prevention and treatment of osteopenia and osteoporosis. These peptides increase bone mineral density in an osteoporotic model and without in vivo side effects, demonstrating clinical effectiveness in the prevention and ...
Furo[3,4-b]pyran compounds and pharmaceutical uses
Victoria Link Limited
March 30, 2017 - N°20170087124

Furo[3,4-b]pyran compounds similar in chemical structure to the natural product known as tan-2483b and their use for treating cancer, osteoporosis, type 2 diabetes, or immune diseases.
Peptides for preventing or treating bone diseases and use thereof
Kyungpook National University Industry - Academic Cooperation Foundation
March 23, 2017 - N°20170081367

The present disclosure relates to a novel peptide for preventing or treating bone diseases. Further, the present disclosure relates to a polynucleotide encoding the peptide, a vector including the polynucleotide, a host cell transformed by the vector, and a method for producing the peptide by using the host cell. Furthermore, the present disclosure relates to a composition for preventing or ...
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Compositions and methods for treatment of osteoporosis and other indications
Transdermal Biotechnology, Inc.
March 23, 2017 - N°20170080016

The present invention generally relates to compositions and methods for treatment of subjects having or at risk of osteoporosis or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles ...
Selective elimination of erosive cells
Novo Nordisk A/s
March 16, 2017 - N°20170073417

The current invention relates to the treatment of diseases characterized by cartilage destruction and/or bone erosion. In particular the present invention relates to the treatment of osteoarthritis, osteoporosis, psoriatic arthritis or rheumatic arthritis with an anti-nkg2a antibody.
Compositions and methods for controlled localized delivery of bone forming therapeutic agents
University Of Rochester
March 16, 2017 - N°20170072062

The present invention provides compositions and methods for providing controllable local delivery of a therapeutic agent to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with osteoporosis, bone cancer or bone fracture. The invention provides a therapeutic agent that is tethered to a polymer to form a therapeutic-tethered macromer, where the therapeutic ...
Use of organic sulphur, antioxidants, and amino acids in conjunction with exercise and electromagnetic stimulation ...
University Of Rochester
March 16, 2017 - N°20170071977

Through the use of a combination of naturally occurring substances, application of mechanical energy by way of exercise, and application of a pulsed electromagnetic field (pemf), new bone formation at lines of stress can be promoted. This bone forming activity is useful in the treatment and prevention of osteoporosis. The naturally occurring substances consist of organic sulphur, antioxidants, and amino ...
Calcium supplement having enhanced absorption
Delavau Llc
March 02, 2017 - N°20170056443

Dietary calcium supplements comprising highly bioavailable forms of calcium carbonate and methods of using these calcium carbonate forms to improve calcium balance, strengthen bones, and prevent, treat, and/or ameliorate bone loss associated with osteoporosis are provided.
Oxazolidine-based compound and selective androgen receptor agonist comprising same
Dong-a St Co., Ltd.
February 23, 2017 - N°20170050955

Provided are novel selective androgen receptor agonists, a preparation method thereof, and a pharmaceutical composition including the same at a pharmaceutically effective amount. The selective androgen receptor agonists according to the present invention act on androgen receptors to increase androgen activity, thereby being usefully applied as a therapeutic and prophylactic agent for diseases or conditions, of which symptoms may be ...
Inhibitor of inflammatory conditions
Compton Developments Ltd.
February 23, 2017 - N°20170049833

The invention relates to boswellia frereana and particularly an extract of same for treating a range of inflammatory disorder or conditions selected from the group comprising: inflammatory bowel disease (ibd), all forms of muscular dystrophy especially duchenne muscular dystrophy, sepsis, sepsis syndrome, osteoporosis, ischemic injury, graft vs. Host disease, reperfusion injury, asthma, diabetes, cancer, myelogenous and other leukemias, psoriasis and ...
Isoform nell-1 peptide
The Regents Of The University Of California
February 16, 2017 - N°20170042968

This application is drawn to a method of using an isoform nell-1 peptide, and compositions thereof for bone formation or for treating, preventing, or ameliorating osteoporosis.
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