 Patent Application Title |
Patent App Num. |
Date |
| Engineering zymogen for conditional toxicity | 20110023194 | 20110127 |
| The ADP-ribosyltransferase, Vip2, exerts its intracellular toxicity in insects by modifying actin and preventing actin polymerization. Due to the nature of this toxin, expression of Vip2 in planta is lethal to the plant. Described herein are methods of making zymogens of toxic proteins that are benign in a non-target organism and are activated in a target organism. Disclosed herein are methods of engineering a random propeptide library at a terminus of a toxic protein and selecting for malfunctional variants in yeast. Using this method a selected proenzyme possesses reduced enzymatic activity as compared to the wild-type Vip2 protein, but remains a potent toxin towards corn rootworm larvae. The Vip2 zymogen can be proteolytically activated by corn rootworm digestive proteases.
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| Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids | 20110023185 | 20110127 |
| The invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids coding for polypeptides with acyltransferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences coding for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, and constructs, vectors and organisms comprising the nucleic acid sequences. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their... |
| Fusion protein comprising a caspase domain and a nuclear hormone receptor binding domain and methods and uses thereof | 20110023137 | 20110127 |
| The present invention relates to a fusion protein comprising a Caspase domain or a functionally active variant thereof and a ligand binding domain of a nuclear hormone receptor, a nucleic acid coding for the fusion protein, a vector or cell comprising the nucleic acid, a method of producing the fusion protein, a non-human transgenic animal containing the nucleic acid, the use of the fusion protein for ligand-mediated induction of apoptosis of a cell, or for studying the function of a cell, tissue and/or organ or the use of a transgenic organism for studying the function of a cell at various developmental stages or as a disease model, a method for inducing apoptosis of a cell expressing a fusion protein or for identifying a ligand, or a... |
| Catheter securement device | 20110021997 | 20110127 |
| An improved catheter securement device, the device having a main body assembly for securing a catheter housing, the assembly adapted to adhesively adher to the skin of a patient, wherein the improvement is a thin, flexible base extension member that is adapted to adher to the patient's skin, the base extension member being provided with an elongated slit dividing the base extension member into two leg portions. The catheter securement device is adhered to the patient such that the venous catheter portion extends through the slit at the insertion site when the catheter housing is properly retained. Preferably, the adhesive utilized to adhere the base extension member to the patient's skin incorporates an anti-microbial composition to combat microorganisms in the area of the insertion site.
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| Selective treatments for chronic rhinosinusitis | 20110021971 | 20110127 |
| Method for treating chronic rhinosinusitis in a human patient. In the method a photosensitizing agent such as indocyanine green can be applied to color a nasal or sinal treatment site harboring infectious microorganisms. The photosensitizing agent can have an energy absorption peak in a near infrared wavelength region of the electromagnetic spectrum. The method can also include applying light energy from a laser source at a near infrared red wavelength or wavelengths to the colored treatment site, for a duration sufficient to control the microorganisms. Apparatus for performing the method is also disclosed.
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| Sulfur-containing proanthocyanidin oligomer composition and production method thereof | 20110021792 | 20110127 |
| Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
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| Material comprising microbially synthesized cellulose associated with a support like a polymer and/or fibre | 20110021701 | 20110127 |
| The invention relates to a material comprising cellulose in association with a support selected from a polymer and/or a fibre, wherein said cellulose is produced by a micro-organism. The cellulose-reinforced material is provided for incorporation into a composite.
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| Plants extracts for use in brain modulation | 20110021613 | 20110127 |
| wherein the substituents are as defined in the description.
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| Means and methods for the specific inhibition of genes in cells and tissue of the cns and/or eye | 20110021605 | 20110127 |
| Described is a method for the specific modulation of the expression of target genes in cells and/or tissues of the CNS and/or eye, wherein a composition comprising one or more doubled stranded oligoribonucleotides (dsRNA) is introduced into the cell, tissue or organism outside the blood-brain or blood-retina barriers. Furthermore, a method for the identification and validation of the function of a gene is provided, wherein the method provides a test cell, test tissue or test organism, which allow information to be gained on the function of the target gene. In addition, compositions and kits are described useful for those methods. In particular, components and methods for the diagnostic use and/or therapy of disorders related to the CNS and/or eye are provided which are based on RNA... |
| Methods and compositions for medical articles produced from proteinaceous compounds | 20110021431 | 20110127 |
| The invention disclosed herein provides compositions and methods for biocompatible biomaterials with improved control of microorganisms, improved biocompatibility, lower toxicity, and reduce vCJD transmission potential. These combined benefits cascade to provide improved efficacy, improved patient compliance and improved performance, while limiting clinical complications in treatment.
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| Recombinant expression plasmid vector and recombinant strain to be used in producing oxalate decarboxylase, and method of producing recombinant oxalate decarboxylase | 20110020938 | 20110127 |
| An object is to provide a means of highly producing an oxalate decarboxylase originating in a microorganism. A recombinant expression plasmid vector, which contains an α-amylase promoter belonging to the genus Bacillus and an oxalate decarboxylase gene originating in a microorganism that is provided under the control of the promoter, is constructed. A host bacterium is transformed with this vector to prepare an oxalate decarboxylase producing bacterium. A recombinant oxalate decarboxylase is produced by culturing the producing bacterium and then recovering the oxalate decarboxylase thus produced.
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| Extraction of co2 gas | 20110020916 | 20110127 |
| A photo-bioreactor is used for extraction of carbon dioxide from exhaust gases of an engine used for compression of natural gas by providing a series of vessels and in each contacting the gases with a labyrinthine flow of water containing photo-synthetic organisms. Each vessel receives the gases in series and is controlled to manage the temperature and dwell time to take into account the reducing CO2 content. The gases are introduced using directional diffusers at the bottom of the bath which generate a flow in the water. Each vessel has a separate water supply and harvesting system so that the excess organisms grown are extracted from each for harvesting. A gas recirculation system is controlled to manage the gas dwell time in the vessel. The divider... |
| Extraction of co2 gas | 20110020915 | 20110127 |
| A photo-bioreactor is used for extraction of carbon dioxide from exhaust gases of an engine used for compression of natural gas by providing a series of vessels and in each contacting the gases with a labyrinthine flow of water containing photo-synthetic organisms. Each vessel receives the gases in series and is controlled to manage the temperature and dwell time to take into account the reducing CO2 content. The gases are introduced using directional diffusers at the bottom of the bath which generate a flow in the water. Each vessel has a separate water supply and harvesting system so that the excess organisms grown are extracted from each for harvesting. A gas recirculation system is controlled to manage the gas dwell time in the vessel. The divider... |
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| Methods for enhancing growth of organisms in an aqueous growth medium | 20110020914 | 20110127 |
| The present invention encompasses a method for enhancing the growth, lipid content and/or protein content of bacteria, microalgae, and fungus grown in an aquatic growth medium.
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| Composition | 20110020892 | 20110127 |
| There is provided an anti-fouling composition comprising (i) a surface coating material; (ii) an enzyme obtained or obtainable from a marine organism; and (iii) (a) a substrate for the enzyme; and/or (b) a precursor enzyme and a precursor substrate, wherein the precursor enzyme and the precursor substrate are selected such that a substrate for the enzyme is generatable by action of the precursor enzyme on the precursor substrate; wherein the enzyme and the substrate are selected such that an anti-foulant compound is generatable by action of the enzyme on the substrate.
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| Process for providing ethanol from plant material | 20110020891 | 20110127 |
| The presently disclosed subject matter relates to processes that comprise the vacuum extrusion of plant materials. In some embodiments, the plant materials are subjected to a change in pressure of −3 kPa or more. The vacuum extrusion can be used to break open the cell walls of the plant material and of any undesirable micro-organisms associated with the plant material. In some embodiments, the vacuum extrusion can be used as a step in a process for producing ethanol from plant materials, such as from sugar beets. In some embodiments, the vacuum extrusion can be used in a process for providing a desired plant cell-derived molecule, such as a sugar or starch.
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| Increased ethanol production by bacterial cells | 20110020890 | 20110127 |
| Fermentation processes for production of ethanol include supplying a thermophilic microorganism lacking lactate dehydrogenase activity with sugars under conditions in which they metabolise them predominantly by the pyruvate-formate lyase pathway. Importantly, the processes also include supplying sufficient glycerol to convert all of the sugars to ethanol. A further embodiment of the invention includes supplying additional glycerol sufficient to convert the exogenous acetate present in biomass hydrolysates into ethanol. Any type of fermentation system can be used for these processes, but a preferred embodiment includes continuous cultures at high temperatures in which ethanol is removed continuously by vacuum evaporation.
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| Yeast organism producing isobutanol at a high yield | 20110020889 | 20110127 |
| The present invention provides recombinant mircoorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
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| Use of glyphosate to produce shikimic acid in microorganisms | 20110020885 | 20110127 |
| The present invention provides methods for producing shikimic acid. In particular the invention provides methods for producing and isolating shikimic acid from a microorganism. Additionally, the invention provides methods for synthesizing compounds such as oseltamivir and 6-fluoroshikimic acid using shikimic acid produced from microorganisms.
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| Method for the conversion of plant materials into fuels and chemicals by sequential action of two microorganisms | 20110020884 | 20110127 |
| A process is disclosed for converting complex plant polysaccharides, including cellulosic materials, into fuels and other chemicals. In preferred embodiments, the process comprises sequential hydrolysis of the plant polysaccharides by two or more microorganisms
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| Acyl-acp thioesterase genes and uses therefor | 20110020883 | 20110127 |
| The present invention provides novel genes encoding Class II acyl-ACP thioesterases and variants thereof that are active on C8, C10, C12, C14, C16, and C18 acyl-ACP substrates. The thioesterases can be introduced into transgenic organisms, including microorganisms and photosynthetic organisms, for producing fatty acids and fatty acid products.
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| Microorganism producing cyclic compound | 20110020872 | 20110127 |
| A microorganism which produces compounds useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, such as mycotic sinusitis, is provided. The present inventors have conducted intensive studies on naturally-occurring microorganisms as a research for antifungal compounds, and found a fungus Acremonium persicinum which produces cyclic compounds having a potent antifungal activity and useful as a medicament, particularly an antifungal agent, and the present invention was completed.
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| Constructs and methods for efficient transformation of micro-organisms for production of carbon-based products of interest | 20110020867 | 20110127 |
| Improved constructs for increasing efficiency of transformation of thermophilic host cells for production of carbon-based products of interest and methods for producing carbon-based products of interest are provided.
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| Method for the real-time detection of microorganisms in a liquid culture medium by agglutination | 20110020861 | 20110127 |
| a method for detecting and identifying at least one target microorganism that may be present in a sample.
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| Method for detection of microorganism and kit for detection of microorganism | 20110020821 | 20110127 |
| d) the step of detecting the microorganism in the test sample treated with the nuclear stain agent by flow cytometry.
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| Method for detection of microorganism and kit for detection of microorganism | 20110020820 | 20110127 |
| d) the step of detecting the microorganism in the test sample treated with the nuclear stain agent by flow cytometry.
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| Use of regulatory sequences for specific, transient expression in neuronal determined cells | 20110020790 | 20110127 |
| The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating... |
| Internal-resistance measuring device for response-delay type fuel cell | 20110020671 | 20110127 |
| One object is to provide a measuring device configured to evaluate the power generation characteristics of a response-delay type fuel cell automatically, precisely, and with excellent reproducibility with consideration of the response delay against power load fluctuations, and effectively acclimatize and develop microorganisms that are provided to generate power. A potentio-galvanostat is connected to a microbial fuel cell provided as an exemplary response-delay type fuel cell. Further, an automatic measuring device is connected to the potentio-galvanostat. The automatic measuring device has a program function and measures the internal resistance of the microbial fuel cell at set time. The internal resistance measurement is executed through the automatic measuring device that instructs the potentio-galvanostat to change a current value flowing to the microbial fuel cell and that repeatedly... |
| Capsule containing nutritional ingredients and method of delivery of a nutritional liquid from the capsule | 20110020497 | 20110127 |
| The invention proposes a capsule (9) for use in a beverage production device, the capsule containing ingredients for producing a nutritional liquid when a liquid is fed into the capsule (9) at an inlet face (8) thereof, the capsule (9) furthermore containing heat sensitive bioactive ingredients such as probiotic microorganisms (21) which are physically separated from the other nutritional ingredients in the capsule.
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| Probiotic, lactic acid-producing bacteria and uses thereof | 20110020306 | 20110127 |
| The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the utilization of one or more species or strains of lactic acid-producing bacteria, preferably strains of Bacillus coagulans, for the control of gastrointestinal tract pathogens, including antibiotic-resistant gastrointestinal tract pathogens, and their associated diseases by both a reduction in the rate of colonization and the severity of the deleterious physiological effects of the colonization of the antibiotic-resistant pathogen. In addition, the present invention relates to the utilization of therapeutic compounds comprised of lactic acid -producing bacteria and anti-microbial agents such as antibiotics, anti-fungal compounds, anti-yeast compounds, or anti-viral compounds. The present invention also discloses methodologies for: (i) the selective breeding and isolation of... |
| Use of regulatory sequences for specific, transient expression in neuronal determined cells | 20110016547 | 20110120 |
| The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating... |
| Information processing system using nucleotide sequence-related information | 20110015870 | 20110120 |
| This invention constructs a highly safe system for processing information for providing semantic information and/or information associated with the semantic information useful for each individual organism through effective utilization of differences in nucleotide sequence-related information among individual organisms. This system comprises steps of: (a) obtaining positional information representing a position in a nucleotide sequence in accordance with a request for an object and/or service; and (b) evaluating adequacy of transmission of nucleotide sequence-related information corresponding to the positional information obtained in step (a), based on the flag information associated with the positional information for evaluating adequacy of transmission of nucleotide sequence-related information associated with the positional information representing a position in a nucleotide sequence.
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| Method for redesign of microbial production systems | 20110015867 | 20110120 |
| A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored.
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| Production of oil in microorganisms | 20110015417 | 20110120 |
| The invention provides methods of cultivating oil-bearing microbes using xylose alone or in combination with other depolymerized cellulosic material. Also provided are microorganisms comprising an exogenous gene encoding a polysaccharide degrading enzyme, such as a cellulase, a hemicellulase, a pectinase, or a driselase. Some methods of microbial fermentation are provided that comprise the use of xylose and depolymerized cellulosic materials for the production of oil-bearing microorgansims.
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| Rna interference mediated inhibition of human immunodeficiency virus (hiv) gene expression using short interfering nucleic acid (sina) | 20110015251 | 20110120 |
| This invention relates to compounds, compositions, and methods useful for modulating human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of human immunodeficiency virus (HIV) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of HIV genes. The small nucleic acid molecules are useful in the treatment of HIV infection, AIDS, and/or disease and conditions related to... |
| Methods for identifying genetic linkage | 20110015084 | 20110120 |
| The present invention provides a high-throughput system for determining linkage of distinct polynucleotides and determining the sequence of polynucleotides that are linked to the distinct polynucleotides. The methods are particularly useful for analyzing transgenes in a transformed host organism. The disclosed methods provide for the detection of linkage between distinct transgenic polynucleotides in transformed hosts and sequencing of DNA regions linked to the distinct transgenic polynucleotides. Methods for identifying a transgenic plant containing a transgene insertion in an undesirable genomic location are also disclosed.
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| Arabidopsis thaliana genome sequence and uses thereof | 20110014706 | 20110120 |
| The present invention relates to nucleic acid sequences from the dicotyldonus plant Arabidopsis thaliana and, in particular, to genomic DNA sequences. The invention encompasses nucleic acid molecules present in non-coding regions as well as nucleic acid molecules that encode proteins and fragments of proteins. In addition, proteins and fragments of proteins so encoded and antibodies capable of binding the proteins are encompassed by the present invention. The invention also encompasses oligonucleotides including primers, e.g. useful for amplifying nucleic acid molecules, and collections of nucleic acid molecules and oligonucleotides, e.g. in microarrays. The invention also provides constructs and transgenic cells and organisms comprising nucleic acid molecules of the invention. The invention also relates to methods of using the disclosed nucleic acid molecules, oligonucleotides, proteins, fragments of proteins,... |
| Production of 1,4 butanediol in a microorganism | 20110014669 | 20110120 |
| A biological method for the conversion of L-glutamate to 1,4-butanediol that involves a decarboxylation step and avoids production of 4-hydroxybutyrate as an intermediate is described. The method includes: (a) conversion of L-glutamate to L-glutamate 5-phosphate; (b) conversion of L-glutamate 5-phosphate to L-glutamate 5-semialdehyde; (c) conversion of L-glutamate 5-semialdehyde to 5-hydroxy-L-norvaline; (d) conversion of 5-hydroxy-L-norvaline to 5-hydroxy-2-oxopentanoate; (e) conversion of 5-hydroxy-2-oxopentanoate to 4-hydroxybutanal; and (f) the conversion of 4-hydroxybutanal to 1,4-butanediol.
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| Organisms for the production of cyclohexanone | 20110014668 | 20110120 |
| A non-naturally occurring microbial organism has cyclohexanone pathways that include at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. A pathway includes a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on C—C bond), a 2-ketocyclohexane-1-carboxylate decarboxylase and an enzyme selected from a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxyl-CoA transferase, and a 2-ketocyclohexane-1-carboxyl-CoA synthetase. A pathway includes an enzyme selected from a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on C—C bond), a 6-ketocyclohex-1-ene-1-carboxyl-CoA synthetase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on thioester), a 6-ketocyclohex-1-ene-1-carboxyl-CoA transferase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA reductase, a 6-ketocyclohex-1-ene-1-carboxylate decarboxylase, a 6-ketocyclohex-1-ene-1-carboxylate reductase, a 2-ketocyclohexane-1-carboxyl-CoA synthetase, a 2-ketocyclohexane-1-carboxyl-CoA transferase, a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxylate decarboxylase, and a cyclohexanone dehydrogenase. A pathway includes an adipate semialdehyde dehydratase, a cyclohexane-1,2-diol dehydrogenase, and a cyclohexane-1,2-diol dehydratase. A pathway includes a 3-oxopimelate decarboxylase,... |
| Production of oil in microorganisms | 20110014665 | 20110120 |
| The invention provides methods of cultivating oil-bearing microbes using cellulosic material. Also provided are microorganisms containing one or more exogenous genes that facilitate the use of cellulosic materials as a feedstock. Also provided are microorganisms and methods for manufacturing non-alcohol-based fuels and fuel feedstocks through a process of converting cellulosic materials into oils.
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| Polypeptide having glyoxalase iii activity, polynucleotide encoding the same and uses thereof | 20110014666 | 20110120 |
| The invention also relates to the production of commodity chemicals, especially 1,2-propanediol, acetol, and lactic acid by fermenting microorganisms wherein their glyoxalase III activity is modulated.
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| Method of producing sialylated oligosaccharides | 20110014661 | 20110120 |
| The present invention relates to a method for the large scale in vivo synthesis of sialylated oligosaccharides, culturing a microorganism in a culture medium, optionally comprising an exogenous precursor such as lactose, wherein said microorganism comprises heterologous genes encoding a CMP-Neu5Ac synthetase, a sialic acid synthase, a GlcNAc-6-phosphate 2 epimerase and a sialyltransferase, and wherein the endogenous genes coding for sialic acid aldolase (NanA) and for ManNac kinase (NanK) have been deleted or inactivated. The invention also relates to these micoorganisms which are capable of producing internally activated sialic acid.
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| Method for production of n36-binding peptide | 20110014649 | 20110120 |
| The present invention relates to the production of an N36-binding peptide at low cost and in a large quantity utilizing a microorganism. More specifically, the present invention relates to a method for producing an N36-binding peptide comprising introducing a recombinant vector into which a DNA molecule encoding an N36-binding peptide that binds to an N36 protein derived from a retrovirus that causes immunodeficiency in a mammal has been incorporated into E. coli as a host to produce a transformant.
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| Targeted chromosomal mutagenesis using zinc finger nucleases | 20110014601 | 20110120 |
| The present invention provides for a method or methods of targeted genetic recombination or mutagenesis in a host cell or organism, and compositions useful for carrying out the method. The targeting method of the present invention exploits endogenous cellular mechanisms for homologous recombination and repair of double stranded breaks in genetic material. The present invention provides numerous improvements over previous mutagenesis methods, such advantages include that the method is generally applicable to a wide variety of organisms, the method is targeted so that the disadvantages associated with random insertion of DNA into host genetic material are eliminated, and certain embodiments require relatively little manipulation of the host genetic material for success. Additionally, it provides a method that produces organisms with specific gene modifications in a short... |
| Microwave disinfection and sterilization | 20110014331 | 20110120 |
| A method and apparatus comprising microwave radiation pulses to reduce a microorganism population in an object.
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| Method for the automatable production of raw sausage | 20110014323 | 20110120 |
| The invention relates to a process for the automatable production of raw sausage by mincing and mixing parts or pieces of meat and adding starter cultures, spices or similar materials. According to the invention, the parts or pieces of meat are supplied as feed stock to the mincing and mixing space (14) over a transport system, especially a multi-piston/cylinder system (1, 2), which can be operated separately from the mincer on the drive side, as a function of the capacity of the mincer (5) or mincers (5) in such a manner, that damming up as well as an increase in temperature and, with that, damage to the feed stock, is avoided. A drying container (6), which takes up exchangeable adsorbents in order to take up water... |
| Compositions comprising dehydrated micro-organisms, method for preparing same, and uses thereof | 20110014278 | 20110120 |
| The invention relates to a composition comprising revivable dehydrated micro-organisms. The invention is characterised in that it further comprises particles at least 50% of which have a mean diameter greater than 250 μm. The invention is applicable, in particular, to human or veterinary pharmaceuticals, to dietetics or to food products.
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| Cosmetic use of microorganism(s) for the treatment of scalp disorders | 20110014248 | 20110120 |
| The present invention relates to a use of an effective amount of at least one probiotic microorganism and/or a fraction thereof and/or a metabolite thereof for preventing and/or treating dandruff disorders of the scalp, as well as a cosmetic process for preventing and/or treating a dandruff condition including the administration a first cosmetic active agent and of at least a second cosmetic active agent, topically, the said first and second cosmetic active agents being formulated in separate compositions, the first cosmetic active agent being chosen from probiotic microorganisms, and mixtures thereof, and the second cosmetic active agent being chosen from antidandruff active agents.
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| Cross-reactive determinants and methods for their identification | 20110014225 | 20110120 |
| Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.
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| Inactivating organisms using carbon dioxide at or near its supercritical pressure and temperature conditions | 20110014184 | 20110120 |
| Whole organisms are inactivated by at least a factor of 106 using carbon dioxide at or near its supercritical pressure and temperature conditions.
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| Probiotics spore-forming lactic acid bacteria sl153 | 20110014166 | 20110120 |
| The present invention relates to the novel Sporolactobacillus vineae SL153 strain (Accession No: KCTC 11493BP) having probiotic activity, precisely Sporolactobacillus vineae SL153 having antimicrobial activity against Vibrio genus pathogenic microorganisms and other pathogens. The Sporolactobacillus vineae SL153 strain of the present invention has excellent intestinal adherence and growth inhibitory effect on pathogenic microorganisms including Vibrio genus microorganisms, so that it can be effectively used as a composition for the prevention and treatment of disease caused by pathogenic microorganisms.
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| Rna interference mediating small rna molecules | 20110014123 | 20110120 |
| Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3′ ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.
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| method and apparatus for on-site nitrate production for a water processing system | 20110014091 | 20110120 |
| An electric plasma arc apparatus and method produces nitrogen compounds, solely using ambient air extracted in proximity to the apparatus. The nitrogen compounds are brought into contact with a water processing system, forming nitrate on-site. Hydrogen sulfide present in the water processing system is removed, and the production of hydrogen sulfide by sulfate-reducing bacteria (SRB) is eliminated by introducing nitrate into the system, whereby denitrifying microorganisms, using the nitrate, outcompete the sulfate-reducing bacteria for the available carbon nutrients, thus preventing the SRB from producing hydrogen sulfide. Nitrate ions generated in the water processing system which contains the denitrifying microorganisms can enhance oil recovery by means of microbial enhanced oil recovery mechanisms. Further, the electric plasma arc apparatus and methodology eliminate major costs of conventional treatment techniques,... |
| Guide apparatus for inducing downward flow of surface water | 20110013987 | 20110120 |
| A guide apparatus for inducing the downward flow of surface water guides a water flow, formed by a tidal current or a wind-driven current, to guide the surface water toward deep water, thereby mixing polluted surface water with deep water such that supersaturated dissolved oxygen of the surface water is transferred to the deep water, and thus, oxygen is fed into a predetermined region of the deep water, which is being rotten due to the deficiency of dissolved oxygen, thereby allowing aerobic microorganisms to metabolize. The guide apparatus includes a hollow floating unit, which is immersed in the water; a balance unit placed on a top end of the floating unit to balance the floating unit; and a balance member attached to a bottom end of... |
| Photoactive nanostructure and method of manufacturing same | 20110012096 | 20110120 |
| A nanostructure comprising at least one semiconductor nanoparticle bound to a photocatalytic unit of a photosynthetic organism is disclosed. The nanoparticle and a binding between the nanoparticle and the photocatalytic unit are selected such that transfer of electrons from the photocatalytic unit to the nanoparticle is prevented or suppressed relative to transfer of excitons from the nanoparticle to the photocatalytic unit. Uses of same and methods of fabricating devices with same are also disclosed. Nanostructures comprising electrically conductive nanoparticles are also disclosed.
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| Removal of selenium in contaminated wastewater streams | 20110011798 | 20110120 |
| Compositions and methods for the removal of selenium species from water containing high-salt concentrations and/or petroleum contaminants are described. The compositions and methods use a selenium-reducing microorganism adapted to adverse environments.
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| System for improving total water qualities in eutrophicated and contaminated water area utilizing water purifying functions of various plants and microorganisms | 20110011780 | 20110120 |
| A system for improving the total water qualities in an eutrophicated and contaminated water area utilizes the water purifying functions of various plants and microorganisms. The system takes the form of a floating inland with plants, which have functions of absorbing eutrophication components from the roots and thus purifying water. The system also contains an anchor for fixing the floating island to the bottom, a weight for controlling the floating conditions of the floating island, and a connecting member for connecting the floating island, the anchor and the weight together. An aquatic plant or an aerobic or anaerobic microorganism capable of absorbing eutrophication components is stuck to at least the lower part of the system in a manner suitable for the environmental conditions of the contaminated... |
| Treated electrical cable | 20110011614 | 20110120 |
| Improved electrical cables employ a protective material thereon for antimicrobial prevention. The electrical cable is formed by a metallic strip helically wound with interlocking edges to define an armor having an inner hollow area within which is housed a plurality of electrical conductors. The armor is treated with a coating which may be used for corrosion protection. The coating is treated with an antimicrobial and/or antifungal additive inhibiting the proliferating or these microorganisms on the cable.
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| Grain wine manufacturing kit using a filter bag | 20110011269 | 20110120 |
| This invention provides a grain wine manufacturing kit which enables a consumer to manufacture grain wine easily. The disclosed gain wine manufacturing kit comprises a filter bag; and grain wine fermentation ingredients including dried and steamed grain and fermentation microorganisms which are filled in the filter bag.
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| Method of directing the evolution of an organism | 20110010806 | 20110113 |
| The present disclosure relates to a method of directing the evolution of an organism by modifying the mutation rate of an organism. The increase in genetic diversity may be used to facilitate the selection of a desired hereditary trait in an organism.
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| Radiosynthesis as an alternative energy utilization process in melanized organisms and uses thereof | 20090328258 | 20091231 |
| This present invention provides methods of enhancing the growth of a microorganism or plant by increasing its melanin content and exposing it to radiation, and methods of using melanized microorganisms to contain or exclude radiation.
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| Novel vip3 toxins and methods of use | 20090328254 | 20091231 |
| Nucleic acid molecules encoding novel Vip3 toxins that are highly active against a wide range of lepidopteran insect pests are disclosed. The nucleic acid molecules can be used to transform various prokaryotic and eukaryotic organisms to express the Vip3 toxins. These recombinant organisms can be used to control lepidopteran insects in various environments.
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| Galactosyltransferase | 20090328251 | 20091231 |
| The present invention provides a method of expressing a plant Lewis-type β1,3-galactosyltransferase in an organism comprising the step of providing the organism with a nucleic acid molecule comprising a sequence A which is defined as being selected from: a) a sequence according to SEQ ID NO: 1 with an open reading frame from base pair 1-1932, j) a sequence which is at least 50% identical with SEQ ID NO: 1, k) a sequence which hybridizes with SEQ ID NO: 1 under stringent conditions, or l) a sequence which has degenerated to SEQ ID NO: 1 due to the genetic code, wherein the sequences a) to d) encode a plant protein having Lewis-type β1,3-galactosyltransferase activity, or m) a sequence which is complementary to one of the sequences... |
| Constitutive plant promoters | 20090328248 | 20091231 |
| Strong, constitutive plant promoters are provided, referred herein to as AA6 promoters, which remain strong and constitutive under biotic and/or abiotic stress conditions. Also provided are transgenic cells and organisms, especially plant cell and plants, comprising an AA6 promoter and methods for expressing nucleic acid sequences in cells and organisms using AA6 promoters.
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| Replication of undifferentiated cells in a weightless environment, uses thereof and a facility for such replication and the acceleration of the evolution of plants and animals | 20090328242 | 20091231 |
| The present invention provides manufacturing processes for biological replication of undifferentiated plant and animal cells and tissue in a weightless condition, including those systems used in current stem cell research and development and use of undifferentiated parenchyma in plants. The present invention further provides methods for adapting plants and animals to survive outside their native environments. In particular, undifferentiated cells from plants or animals are replicated under weightless conditions in which cell replication or proliferation is accelerated and sustained. Under such conditions, the undifferentiated cells can be “forced” to express sets of genes useful for survival in particular environmental conditions. In this manner, cells surviving prolonged exposure to specific environmental conditions can be selected for and cultivated to produce an organism adapted to that particular environment... |
| Genetically modified mice as predictors of immune response | 20090328240 | 20091231 |
| The invention is directed to novel genetically modified organisms and uses thereof. In particular, the invention is directed to novel genetically modified mice and uses of such mice to assess the immunogenic potential of human therapeutic antigens and to predict immune responses.
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| Anti-microbial photodynamic therapy | 20090326434 | 20091231 |
| Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The key to these conjugates is a special spacer connecting at least one photosensitizer to a microorganism receptor (vector) which in turn binds selectively to the surface of a microorganism bringing about photo-destruction upon irradiation. Spacers having hydrophilic structure such as ethylene glycol units and amino carboxyl end capped ethylene glycol units must be used for linking the vector to the photosensitizer. In a preferred embodiment a spacer would have at least 3 ethylene glycol units and be end capped with a carboxyl group on one end and a amino group at the other end. The present invention effectively works to combat bacterial infection in... |
| Detecting infection in reduced pressure wound treatment | 20090326416 | 20091231 |
| Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site. Additionally, a porous pad comprising luciferase is provided.
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| Protection of normal cells | 20090326073 | 20091231 |
| The invention provides compositions comprising sulindac, R-epimer sulindac, S-epimer sulindac, derivatives, metabolites, and structural analogs thereof which protect normal cells against damage caused by solar rays, oxidative damage, environmental factors, diseases and organisms.
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| Antiviral use of cationic surfactant | 20090326031 | 20091231 |
| Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the protection against the growth of the microorganisms. The cationic surfactants of this type are also effective against virus infections. Addition of LAE to cultures of Herpes virus type 1 Vaccinia virus and bovine parainfluenzae 3 virus leads to nearly complete reduction of the virus organisms in these cultures, such effects being observed after 5 and 60 minutes.
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| Gyrase inhibitors and uses thereof | 20090325955 | 20091231 |
| The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
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| Novel glyphosate-n-acetyltransferase (gat) genes | 20090325804 | 20091231 |
| Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.
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| Pro-apoptotic bacteria and compositions for delivery and expression of antigens | 20090325298 | 20091231 |
| Whole-cell vaccines and methods for enhancing the immunogenicity of cellular microorganisms for use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria or for use as vectors to express exogenous antigens and induce responses against other infectious agents or cancer cells. The present invention involves an additional method of enhancing antigen presentation by intracellular bacteria in a manner that improves vaccine efficacy. After identifying an enzyme that has an anti-apoptotic effect upon host cells infected by an intracellular microbe, the activity of the enzyme produced by the intracellular microbe is reduced by expressing a mutant copy of the enzyme, thereby modifying the microbe so that it increases immunogenicity.
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| High eicosapentaenoic acid producing strains of yarrowia lipolytica | 20090325265 | 20091231 |
| Lysophosphatidic acid acyltransferase [“LPAAT”] participates in the second step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty acids [“LC-PUFAs”] produced in oils of oleaginous organisms. An LPAAT isolated from Mortierella alpina [“MaLPAAT1”] that is suitable for use in the manufacture of oils enriched in LC-PUFAs in oleaginous organisms is disclosed. Most desirably, the substrate specificity of the instant MaLPAAT1 will be particularly useful to enable increased C18 to C20 elongation conversion efficiency and increased Δ4 desaturation conversion efficiency in recombinant host cells producing LC-PUFAs.
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| Highly active xylose reductase from neurospora crassa | 20090325254 | 20091231 |
| A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a preference of NADPH over NADH. This enzyme is utilized in production of xylitol and other sugar alcohols such as sorbitol and also in the metabolic enhancement of organisms used for fermentation of plant biomass into ethanol.
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| Methods and systems for production of biofuels and bioenergy products from sewage sludge, including recalcitrant sludge | 20090325253 | 20091231 |
| The present invention provides methods and systems (SLUDFUEL system) for producing biofuel and bioenergy products using, as starting raw material, municipal, industrial, and/or farm sewage sludge, including recalcitrant sludge containing high concentrations of heavy metals, and produced after waste treatment. In accordance with the invention, municipal, industrial, and farm sewage sludge, including recalcitrant sludge, can serve as a carbon source to support the metabolism of synthetic microorganisms to produce biofuels and bioenergy products.
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| Method for producing amino acids using glycerol | 20090325243 | 20091231 |
| The present invention relates to an amino acid-producing microorganism capable of simultaneously utilizing glycerol as a carbon source, a method for preparing the microorganism, and a method for producing amino acids using the microorganism. According to the present invention, amino acids can be efficiently produced using a byproduct of biodiesel production, glycerol, thereby substituting a cheaper material for the conventional fermentation materials such as glucose.
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| Tissue sample preparation and maldi ms imaging thereof | 20090325222 | 20091231 |
| Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis.
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| Methods and apparatus for sterility testing | 20090325220 | 20091231 |
| Methods and apparatus for testing the sterility of a product to be administered to a patient. The sterility of the product is tested by monitoring the pH change of a culture medium in contact with any culturable organisms (e.g., bacteria) that are collected by filtration of the product to be tested.
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| Determination of lipid, hydrocarbon or biopolymer content in microorganisms | 20090325218 | 20091231 |
| y represents the weight % of the cell biomass in the cell culture.
... |
| Data standard for biomaterials | 20090325212 | 20091231 |
| Provided are systems and/or methods that facilitate sensing, detecting, logging, or treatment of a condition or need of a living body using a genetically engineered organism and a data standard.
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| Kit and method for quantitatively detecting multiplepathogens without gene amplification | 20090325161 | 20091231 |
| A non-amplification multiple quantitative detection kit is characterized in that there are provided a single strand poly nucleotide having a base sequence invented to recognize a specific gene portion of a multilepathogens microorganism to be detected by a fishing probe, and a double strand poly nucleotide indicated with a tag having a base sequence invented to recognize different gene portions which are not duplicated with the recognition portion of the fishing probe in the specific genes of the multilepathogens microorganism to be detected by a reporter probe.
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| Molecularly imprinted polymers for detecting microorganisms | 20090325147 | 20091231 |
| The invention described herein provides molecularly imprinted polymers (MIPs) that are capable of binding to a microorganism, and methods for detecting and/or identifying microorganisms utilizing Molecularly Imprinted Polymers (MIPs). The microorganisms of the invention include prokaryotes, eukaryotes, virus and prions. The methods of the invention comprise detecting all or part, including epitopes, of macromolecules associated with the microorganisms. The macromolecules of the invention include polysaccharides, proteins, glycoproteins, peptidoglycans, lipoproteins, peptides, polypeptides, and polynucleotides, associated with said microorganisms. The invention also provides for methods of diagnosing a subject infected with the microorganisms utilizing MIPs, in addition to diagnostic kits.
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| Peracid and 2-hydroxy organic acid compositions and methods for treating produce | 20090324789 | 20091231 |
| Methods and compositions for treating produce to control microorganisms are provided. The method treats produce by contacting the surface of the produce with an aqueous solution comprising i) an organic peracid of the formula RC(O)OOH wherein R is methyl, ethyl, n-propyl, or s-propyl; ii) a 2-hydroxy organic acid selected from tartaric acid, citric acid, malic acid, mandelic acid, and lactic acid; and (optionally) iii) an anionic surfactant; wherein the aqueous solution has a pH from 2.5 to 6.0.
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| Compositions and methods for treating and preventing infection | 20090324643 | 20091231 |
| This invention relates to cholesterol-sequestering agents and methods of using cholesterol-sequestering agents to treat or prevent infection. The compositions of the invention can be used in vitro or in vivo to decrease the load of a microorganism in a biological sample. Methods of generating an immune response against a microorganism are also included.
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| Microorganism capable of controlling plant diseases and plant disease-controlling agent using the microorganism | 20090324564 | 20091231 |
| The object of the present invention is to provide a microorganism which places little burden on the environment, shows an extremely low possibility of a resistant pathogenic bacterium to emerge, and has a superior controlling ability against various plant diseases (in particular, soft rot and canker of leaf and root vegetables); a plant disease controlling agent containing the microorganism; and a method for controlling plant diseases comprising applying the plant disease controlling agent to the plant and/or the grove soil thereof. A plant disease controlling agent is used which contains a bacterial cell of Pseudomonas rhodesiae having controlling ability against plant diseases, preferably a bacterial cell of Pseudomonas rhodesiae FERM BP-10912 or its variant having controlling ability against plant diseases.
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| Composition and method for inhibition of microorganisms | 20090324550 | 20091231 |
| A composition and method for the inhibition of microorganisms.
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| Methods and composition for treating a material | 20090324514 | 20091231 |
| A composition and method are described for sanitizing or otherwise treating a material such as a non-living surface, living tissue, soil or atmosphere which may be contaminated by a toxin, chemical warfare agent, insect, prion, microorganism or other infectious agent. The composition generally includes an aqueous composition mixture that includes: (a) lower alkanol; (b) an alkalinating agent, and (c) a fatty acid salt and/or ester. The components are present in an effective amount to sanitize (or treat) a material (or modifying a chemical contained thereon) to which the composition is applied. Also described are methods of making the composition.
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| Surfactant gas pressurized liquid composition and method and package for delivering | 20090324505 | 20091231 |
| A self gassing composition comprising at least one surfactant and a fermentation base including a gas producing organism and at least one sugar is disclosed. Use of a nonionic surfactant in the self gassing composition allows the fermentation base to continue reacting and producing gas. Additionally, a personal care cleansing product and method for storing and delivering an aqueous composition having at least one surfactant and pressurized gas dissolved therein is disclosed. In one aspect, the composition is stored in an internal reservoir in a container such that when a sealing device is removed from a valveless opening, the composition foams and plumes out the opening of the container as the gas dissolved in the composition is released. In addition to the self gassing composition, a... |
| Screen for inflammatory response modulators | 20090324500 | 20091231 |
| The present invention relates to transgenic aquatic vertebrate organisms and methods of their use in screening for, or identifying agents that are useful in modulating the inflammatory response and particularly for identifying agents useful for treating inflammatory disorders.
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| Use of an anode for elimination or reduction of microbial impurities in liquids. | 20080314760 | 20081225 |
| The present invention relates to the use of an anode suitable for use in inter alia a reactor for elimination or reduction of microbial impurities from liquids, such as inter alia waste water and water intended for human or animal consumption. The anode comprises an expanded metal plate, preferably titanium, covered with a non-corrosive metal layer, preferably a platinum layer. The surface of the anode is endowed with dents, which enhances the electrochemical effect between the anode and the corresponding cathode and thereby enhances the microbial effect and at the same time reduces the energy required to obtain an efficient kill of the microorganisms,
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| Apparatus and method for the treatment of waste | 20080314828 | 20081225 |
| A facility for treating solid and liquid waste includes a receiving station, a screening station, a preprocessing station, a press station and a processing station. The screening station is connected to an inlet capable of receiving liquid and solid waste and includes a screen for capturing at least some of the solid waste. The preprocessing station is in fluid communication with the screening station, and includes a degrit chamber for settling out an additional amount of the solids. The press station included at least one alkali mixing tank and a screw press for separating out an additional portion of the solids. The processing station includes at least one aerobic microorganism generating unit for converting nitrites into nitrogen gas and consuming carbon-based waste material.
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| Method for treating microorganisms and/or infectious agents | 20080317702 | 20081225 |
| This invention relates to a method comprising contacting a microorganism and/or an infectious agent with an effective amount of a polymer composition to reduce or eliminate the reproductivity, metabolism, growth and/or pathogenicity of the microorganism and/or infectious agent, the polymer composition comprising water, a water-soluble film forming polymer, a chelating agent, and a surfactant.
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| Bioconjugated nanoparticles | 20080317768 | 20081225 |
| The present disclosure relates to compositions and methods for the treatment of a disease, e.g., cancer or pathogenic infection, using a bioconjugated nanoparticle comprising a biocompatible quantum dot conjugated to a targeting moiety. The targeting moiety allows for the nanopaticle to bind to a cancer cell or pathogenic organism. The quantum dot, upon excitation by soft x-rays, emits electromagnetic radiation at a frequency of ultraviolet light, thereby allowing for the disruption of the DNA found in the cancer cell or pathogenic organism.
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| Vaccine | 20080317785 | 20081225 |
| The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis (M. ptb) substantially free of whole organisms of that species either dead or alive. The secreted protein may be obtained from a culture of M. ptb with the microorganisms being removed by centrifugation and subsequent filtration. The vaccine may be used for vaccination against Johne's disease
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| Use of k -252a and kinase inhibitors for the prevention or treatment of hmgb1-associated pathologies | 20080317809 | 20081225 |
| The present invention relates to the use of K-252a, a physiologically active substance produced by microorganisms, and of its salts or synthetic and/or chemically modified derivatives for the prevention or treatment of HMGB1 associated pathologies. More particularly, the present invention relates to the use of K-252a for the prevention or treatment of restenosis.
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| Induction of a physiological dispersion response in bacterial cells in a biofilm | 20080317815 | 20081225 |
| where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required... |
| High pressure processing of bioactive compositions | 20080317823 | 20081225 |
| The present invention relates to a method of pressure treating a bioactive composition comprising at least one bioactive component to prevent the growth of at least one unwanted microorganism while retaining a desired level activity of the at least one bioactive component. The bioactive component is selected from one or more proteins protein hydrolysates, one or more lipids or lipid hydrolysates, one or more carbohydrates, one or more probiotic factors, or mixtures thereof. The pressure treatment is at a predetermined pressure from about 350 to 1000 MPa.
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| Devices and methods for the selection of agents with efficacy against biofilm | 20080318268 | 20081225 |
| This invention is a diagnostic plate that can be used to select antibiotic combinations with efficacy against microorganisms growing as a biofilm. The plate allows growth of biofilm on a plurality of projections, and the subsequent simultaneous challenge of biofilms on all projections of the plate to independent concentrations and combinations of anti-biofilm agents. Resistance of microorganisms to antibiotics is higher when they grow as a biofilm, as compared to when they grow in a planktonic state which is usually used to determine their level of antibiotic sensitivity. Growth of microorganisms that slough off the biofilm in the anti-biofilm agent challenge determines the Minimum Inhibitory Concentration (MIC) which relates to sensitivity of the microorganisms in a planktonic state. Growth of any surviving microorganisms from the biofilm... |
| devices and methods for the analysis of biofilm | 20080318269 | 20081225 |
| This invention is a diagnostic plate that can be used to select antibiotic combinations with efficacy against microorganisms growing as a biofilm. The plate allows growth of biofilm on a plurality of projections, and the subsequent simultaneous challenge of biofilms on all projections of the plate to independent concentrations and combinations of anti-biofilm agents. Resistance of microorganisms to antibiotics is higher when they grow as a biofilm, as compared to when they grow in a planktonic state which is usually used to determine their level of antibiotic sensitivity. Growth of microorganims that slough off the biofilm in the anti-biofilm agent challenge determines the Minimum Inhibitory Concentration (MIC) which relates to sensitivity of the microorganisms in a planktonic state. Growth of any surviving microorganims from the biofilm... |
| Methods and compositions for combinatorial-based production of multivalent recombinant antigens | 20080318274 | 20081225 |
| The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.
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| Processes for producing a fermentation product | 20080318284 | 20081225 |
| The present invention relates to processes for producing a fermentation product comprising (a) saccharifying starch-containing material below the initial gelatinization temperature in the presence of i) from 0.001-50 AGU/g DS, preferably 0.01 to 10 AGU/g DS alpha-glucosidase activity more than the native amount of endogenous alpha-glucosidase present in the starch-containing material, and ii) from 0 (zero) to 10 FAU-F/g DS of alpha-amylase activity, and (b) fermenting using a fermenting organism. The invention also relates to an enzymatic composition for use in a process of the invention.
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| P1-35 expression units | 20080318286 | 20081225 |
| The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
... |
| Fermentative production of organic compounds using substances containing dextrin | 20080318287 | 20081225 |
| enzymes which hydrolyze the dextrins to monosaccharides being added in an amount of less than 0.001% by weight based on the total weight of the starch feedstock employed, or not at all.
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| Fermentation processes for the preparation of tacrolimus | 20080318289 | 20081225 |
| The present invention relates to improved fermentation processes for the preparation of tacrolimus or a salt or derivative thereof by culturing a microorganism capable of producing tacrolimus or a salt or derivative thereof under submerged aerobic conditions with fed-batch processing at a high aeration rate.
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| Anaerobic microbial composition and methods of using same | 20080318303 | 20081225 |
| A microbial composition for concurrent dechlorination of a mixture of chlorinated ethanes and chlorinated ethenes includes a isolated consortium of bioremediative microorganisms comprising strains of microorganism comprising Clostridium, Acetobacterium, Dehalobacter, Bacteroides, and Proteobacteria. The composition may also include Methanomicrobia.
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| Microbe-resistant hair removal paddle | 20080318508 | 20081225 |
| In connection with microbe resistance, advantageous rubber components are also presented.
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| Modulators of the development of mychorrizal fungi with arbuscules, and uses thereof | 20080318773 | 20081225 |
| The identification of compounds, strigolactones, having the ability to stimulate the growth and/or development of arbuscular mycorrhizal fungi (AM fungi). Such compounds are, for example, the natural strigolactones strigol, alectrol, sorgolactone, orobanchol, or their synthetic analogs GR7, GR24, Nijmegen-1, demethylsorgolactone. New ways of developing an agriculture that is more respectful of the environment, and permits the implementation, on a small or large scale, of advanced mycorrhization techniques aimed at optimizing the production of fungic inoculum, the use of AM fungi in soils or cultivation substrates, and intensifying the symbiotic interaction between these microorganisms and cultivated plants.
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| Suspension of active compounds in glycerol | 20080318774 | 20081225 |
| The present invention relates to active compound suspensions comprising at least 60% by weight of glycerol, agrochemically active compounds, wetting agents, dispersants and antifoams, and also optionally agents for adjusting rheological properties, acids for adjusting the pH, preservatives and further components, such as formulation auxiliaries, surfactants and solvents. The active compound suspensions and the agrochemical compositions obtainable therefrom can be used for controlling harmful organisms.
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| Process for the production of fine chemicals | 20080318790 | 20081225 |
| The present invention relates to a process for the production of methionine in an organism such as a microorganism, a non-human animal or plant. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.
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| Methods and compositions regarding polychalcogenide compositions | 20080318864 | 20081225 |
| The present invention concerns the use of polychalcogenide compositions on cells, tissue, organs, and organisms to enhance their survivability. It includes compositions, compounds, methods, articles of manufacture and apparatuses for enhancing survivability and for protecting them from or treating them for injury or damage. In specific embodiments, there are also therapeutic methods and apparatuses for hypoxic/ischemic injury, organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the polychalcogenide compositions described.
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| Methods for altering gene expression and methods of treatment utilizing same | 20080318884 | 20081225 |
| The present disclosure describes methods for altering the expression of a target gene comprising a rare cluster of codons, including, but not limited to, trinucleotide repeats. The method utilizes, in part, on amino acid deprivation or the limiting of specific charged tRNAs. The methods for altering target gene expression may be used in treatment methods to treat diseases in a subject organism in need of such treatment. Such methods for altering target gene expression have not been heretofore recognized in the art. Exemplary diseases that may be treated using the methods of the present disclosure include any disease where altering the expression of the target gene would provide treatment. Such diseases include all forms of cancer, ageing, infectious disease, metabolic disorders, inflammation, neurological disorders, diabetes, psychiatric... |
| Medical-use two part reactive adhesive and medical-use resin having self-degradation property | 20080319101 | 20081225 |
| Medical-use two-part adhesive comprising; first part comprised of an aqueous solution or a powder of aldehyde-groups-introduced alpha-glucan; and second part comprised of an aqueous solution or a powder of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000; as well as medical-use hydrogel resin obtained by curing the adhesive. A mixture of the first and second parts, at a time of mixing them to form the hydrogel has pH in a range of 5.0 to 8.0. In a preferred embodiment, the amino-groups-containing polymer is epsilon-poly-L-lysine produced by microorganism or by enzyme.
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| Implantable power sources and sensors | 20080319287 | 20081225 |
| A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be... |
| Alteration of the skin and nail for the prevention and treatment of skin and nail infections | 20080319517 | 20081225 |
| The method of prevention and treatment of microbial infections that occur on, or just below, the skin and nails of a person consisting of applying a means to inactivate the microbes thus rendering them harmless. The treatment consists of applying a means which alters the skin or nail so that the skin or nail will either no longer serve as a food source, will be inhibitory to the organism, will be toxic to the organism, or will be altered in a manner that makes it more responsive to treatment of infections.
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| Electrodeposition baths containing a mixture of boron-containing compounds and chlorhexidine | 20080308423 | 20081218 |
| Disclosed is an electrodeposition bath comprising a mixture of (i) at least one boron-containing compounds and (ii) chlorhexidine for controlling the growth of microorganisms in the electrodeposition bath. The combination of (i) and (ii) at a low concentration provides better control of microbes than does either (i) or (ii) at higher concentrations.
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| Biological treatment and filtration system equipment | 20080308479 | 20081218 |
| The present invention provides a biological treatment and filtration system equipment that can reliably remove most of materials harmful to the human body and arsenic components not capable of being removed until now, which are contained in the raw water, by a series of purification operations. A biological treatment and filtration system equipment includes a filter sand layer 111 that treats raw water by microorganism to filter impurities; a raw-water supplying unit 112 that is provided on the upper side of the filter sand layer; an outlet 113 that is provided on the lower side of the filter sand layer and is used to take out filtered water; a filtering net 114 that is detachably held on the upper side of the filter sand layer in... |
| System and method of organism identification | 20080310692 | 20081218 |
| A system and method for identifying organisms by analysis of scattergrams of colonies is disclosed. cattergrams are obtained by culturing samples and illuminating the resultant colonies by a laser. The forward scattered light is imaged and subject to a feature extraction process. The feature vector may include Zernike or Chebyshev moments and may also include Harelick texture features. Feature vectors may be used to train a classification process using either supervised or unsupervised machine learning techniques. The classification process may be used to associate a colony phenotype with the genotype of the sample.
... |
| Transmissive window for hydrooptic disinfection system | 20080311012 | 20081218 |
| Some demonstrative embodiments of the invention include an illumination-based liquid disinfection device. The disinfection device may include, for example, a conduit to carry a flowing liquid to be disinfected, the conduit having an inlet to receive the liquid and an outlet to discharge the liquid; at least one illumination source external to the conduit to illuminate the liquid with light through a shaped non-flat window. The non-flat window may redistribute the light in the conduit so as to improve uniformity of light-dose received by entities such as micro-organisms and or chemicals within the liquid.
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| Preparation of soluble and colloidal molecularly imprinted polymers by living polymerization | 20080311072 | 20081218 |
| The present invention describes a method for synthesis of relatively low molecular weight imprinted polymers using living polymerization, and their application in analytical chemistry, pharmacology, medicine and the food industry. Specifically the low-molecular weight polymers are synthesized by the polymerization of functional monomers in the presence of a template, such as a biological receptor, enzyme, nucleic acid, cell, virus, microorganism, tissue sample or drug using living initiator. The conditions of living polymerization ensure a relatively small size of synthesized molecules. Synthesized in this way molecules (dimers, oligomers, polymers, or their mixture) have a higher affinity to the template than the original monomers and can rebind it in vitro and/or in vivo. As a further aspect of the present invention, polymers synthesized as described above can be... |
| Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material | 20070295505 | 20071227 |
| Methods of stimulating biogenic production of a metabolic product with enhanced hydrogen content are described. The methods may include accessing a consortium of microorganisms in a geologic formation that includes a carbonaceous material. They may also include providing a phosphorous compound to the microorganisms. The phosphorous compound stimulates the consortium to metabolize the carbonaceous material into a metabolic product with enhanced hydrogen content. Also, methods of stimulating biogenic production of a metabolic product with enhanced hydrogen content by providing a yeast extract amenment to a consortium of microorganisms is described. The yeast extract amendment stimulates the consortium to metabolize carbonaceous material in the formation into the metabolic product with enhanced hydrogen content.
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| Robust expression of a bioactive mammalian protein in chlamydomonas chloroplast | 20070298050 | 20071227 |
| Methods and compositions are disclosed to engineer chloroplast comprising heterologous mammalian genes via a direct replacement of chloroplast Photosystem II (PSII) reaction center protein coding regions to achieve expression of combinant protein above 5% of total protein. When algae is used, algal expressed protein is produced predominantly as a soluble protein where the functional acitivity of the peptide is intact. As the host algae is edible, production of biologics in this organism for oral delivery or proteins/peptides, especially gut active proteins, without purification is disclosed.
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| Method for depletion of caries-causing bacteria in the oral cavity | 20070298060 | 20071227 |
| Herein is provided a method for treating or preventing caries by applying a caries-causing agent removal device, a device capable of selectively and preferentially binding the caries-causing agent compare with other surrounding non-cariogenic organisms. There is also provided a set of compounds for formulating the device thereof. Exemplary compounds include glycosidic polymers such as Sephadex®. Specific examples of a device of the present invention include candy, chewing gums, mouthwash, and toothpaste
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| Physiologically active agents containing vicinal dithioglycols and use thereof in various branches of economy | 20070298081 | 20071227 |
| The invention relates to the food and medical industries, medical cosmetics, dermatology, agriculture and the mixed feed industry. According to the invention vicinal dithioglycole (common formula RCH(SH)CH(SH)R−1 (I)) is used as a food additive, a food product, physiologically-active substances and active ingredients of forage additives and of forage, in cosmetic and/or dermatological and skin-therapeutic remedies. The invention comprises methods for producing such additives, products and remedies. The substance of formula (I) stimulates physiological processes, increases human and animal immunity, inhibits undesirable process in organisms and food products, produces curative and preventive action of skin, hair and nails and after vicinal dithioglycole is administered the intoxication effect of alcohol consumption known as hang-over is completely remored.
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| Tussi bag | 20070298086 | 20071227 |
| (c) Devise an appropriate means of disposal of the contaminated materials once the infection has run its course.
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| Method for protecting bioactive food ingredients using decoy ingredients | 20070298144 | 20071227 |
| The invention concerns a food product containing one or more living microorganisms and at least one bioactive food ingredient of interest, wherein said bioactive food ingredient(s) of interest are protected: physically, said bioactive food ingredient(s) of interest being preferably encapsulated; and/or by means of at least one decoy food ingredient contained in said food product such that their metabolization by said living microorganisms is reduced. More particularly, the invention concerns a food product containing living microorganisms, bioactive ingredients of interest and decoy ingredients.
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| Fluorescent proteins and chromoproteins from non-aequorea hydrozoa species and methods for using same | 20070298412 | 20071227 |
| The present invention provides nucleic acid molecules encoding a fluorescent and chromo-proteins and mutants, variants and derivatives thereof, as well as proteins and peptides encoded by these nucleic acids. The nucleic acid molecules and proteins of interest are isolated from non-Aequorea Hydrozoa species. The proteins of interest include yellow fluorescent protein, phiYFP, from Phialidium sp., green fluorescent protein hydr1GFP and purple chromoprotein, hm2CP from hydroid medusae of sub-order Anthomedusae. Also of interest are proteins that are substantially similar to, or derivatives, or homologues, or mutants of, the above-referenced specific proteins. Also provided are fragments of the nucleic acids and the peptides encoded thereby, as well as antibodies specific to the proteins and peptides of the invention. In addition, host-cells, stable cell lines and transgenic organisms comprising... |
| Constructs for gene expression analysis | 20070298417 | 20071227 |
| The present invention relates generally to constructs and their use in gene expression or gene regulation assays. More particularly, the present invention provides expression vectors and/or reporter vectors providing kinetics of protein expression with improved temporal correlation to promoter activity. Even more particularly, the invention provides expression vectors comprising a transcribable polynucleotide which comprises a sequence of nucleotides encoding a RNA element that modulates the stability of a transcript corresponding to the transcribable polynucleotide. The present invention provides, inter alia, novel vectors, useful for identifying and analysing cis- and trans-acting regulatory sequences/factors as well as vectors and genetically modified cell lines or organisms that are particularly useful for drug screening and drug discovery.
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| Identification of multiple biological (micro) organisms by specific amplification and detection of their nucleotide sequences on arrays | 20070298423 | 20071227 |
| The present invention is related to a method for identifying and/or quantifying an organism or part of an organism in a sample by detecting a nucleotide sequence specific of said organism, among at least 4 other nucleotide sequences from other organisms or from parts of the organism. The method includes the steps of: amplifying the specific nucleotide sequences by PCR into double stranded target nucleotide sequences using specific primers, as to produce full-length target nucleotide sequences having between 60 and 800 bases, said specific primers show a homology of less than 50% and even better less than 30% with the other primer pairs specific of the 4 other nucleotide sequences; contacting the target nucleotide sequences resulting from the amplifying step with at least 5 different single-stranded... |
| Method of preparing 2-deoxyribose 5-phosphate | 20070298467 | 20071227 |
| The present invention discloses a method of preparing 2-deoxyribose 5-phosphate by reacting glyceraldehyde 3-phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase but substantially no phosphatase or the enzyme derived from the microorganism. The present invention also discloses a method of preparing 2-deoxyribose 5-phosphate by reacting dihydroxyacetone phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase and triose-phosphate isomerase but substantially no phosphatase or the enzymes derived from the microorganism.
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| Method of preparing 2-deoxyribose 5-phosphate | 20070298468 | 20071227 |
| The present invention discloses a method of preparing 2-deoxyribose 5-phosphate by reacting glyceraldehyde 3-phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase but substantially no phosphatase or the enzyme derived from the microorganism. The present invention also discloses a method of preparing 2-deoxyribose 5-phosphate by reacting dihydroxyacetone phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase and triose-phosphate isomerase but substantially no phosphatase or the enzymes derived from the microorganism.
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| Isolated dna comprising one or more genes specific for 5s clavam biosynthesis, vectors comprising such dna and streptomyces hosts capable of improved clavulanic acid production | 20070298470 | 20071227 |
| Novel bacterial genes, microorganisms and processes for improving the manufacture of 5R clavams, eg. clavulanic acid.
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| Pentose-fermentative transformed zymobacter microorganisms | 20070298476 | 20071227 |
| This invention provides transformed microorganisms which can produce ethanol from pentose, by introducing pentose metabolizing enzymes into microorganisms belonging to genus Zymobacter which cannot utilize pentose.
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| Process for stimulating production of hydrogen from petroleum in subterranean formations | 20070298479 | 20071227 |
| A process for stimulating microbial hydrogen production in a petroleum-bearing subterranean formation, comprising: (a) analyzing one or more components of the formation to determine characteristics of the formation environment; (b) detecting the presence of a microbial consortium, comprising at least one fermentative syntrophic microorganism, within the formation; (c) assessing whether the formation microorganisms are currently active; (d) determining whether the microbial consortium comprises one or more fermentative syntrophic microorganisms; (e) characterization of one or more fermentative syntrophic microorganism of the consortium, and comparing the one or more characterized organisms with at least one known characterized known microorganism having one or more known physiological and ecological characteristics; (f) characterizations of one or more hydrogen consuming microorganism, such as (but not exclusively) methanogens and sulphate reducers, of the... |
| Method to increase carotenoid production in a microbial host cell by down-regulating glycogen synthase | 20070298483 | 20071227 |
| A method to increase carotenoid production in carotenogenic microbial host cells is provided by down-regulating or disrupting glycogen synthesis. Disruption of glycogen synthase activity in a carotenogenic microbial host cell significantly increased carotenoid production. Carotenogenic microorganisms are also provided that have been optimized for the production of carotenoid compounds through the down-regulation and/or disruption of glycogen synthase activity.
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| Waste treatment apparatus | 20070298488 | 20071227 |
| A waste treatment apparatus decomposes waste by the microorganisms to perform annihilation treatment. The waste treatment apparatus includes a treatment tank which accommodates the microorganisms together with the waste, and an agitation device arranged to agitate the microorganisms together with the waste. The agitation device includes a plurality of agitating tools arranged at predetermined intervals in the axial direction of a rotation shaft. The agitating tools have paddle arms, respectively, which are disposed so as to be opposed to each other in a diameter direction of the rotation shaft, and blades, respectively, which are disposed at predetermined distances apart from an inner wall of the treatment tank and are inclined with respect to the axis of the paddle arms. The blade on one side is inclined... |
| Analyzing traslational kinetics using graphical displays of translational kinetics values of codon pairs | 20070298503 | 20071227 |
| Graphical displays are provided of translational kinetics values of codon pairs in a host organism plotted as a function of polypeptide-encoding nucleotide sequence. Such translational kinetics values of codon pair frequencies correspond to the predicted translational pausing properties of a codon pair in a host organism. The graphical displays provided reflect the relative over-representation or under-representation of each codon pair in an organism, thereby facilitating analysis of translational kinetics of an mRNA into polypeptide by comparing graphical displays of different codon pairs in sequences encoding the polypeptide. The graphical displays of translational kinetics values also can display codon pair properties on comparable numerical scales, thereby facilitating analysis of translational kinetics of an mRNA into polypeptide in different organisms by comparing comparably scaled graphical displays of the... |
| Casein hydrolyzate, process for producing the same and use thereof | 20070299014 | 20071227 |
| The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
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| Degradable polyurethane foams | 20070299151 | 20071227 |
| A method of synthesizing of a biocompatible and biodegradable polyurethane foam includes the steps of: mixing at least one biocompatible polyol, water, at least one stabilizer, and at least one cell opener, to form a resin mix; contacting the resin mix with at least one polyisocyanate to form a reactive liquid mixture; and reacting the reactive liquid mixture form a polyurethane foam. The polyurethane foam is preferably biodegradable within a living organism to biocompatible degradation products. At least one biologically active molecule having at least one active hydrogen can be added to form the resin mix.
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| Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system | 20070300313 | 20071227 |
| This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
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| Grg32: a novel epsp synthase gene conferring herbicide resistance | 20070300325 | 20071227 |
| Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include nucleic acid molecules encoding herbicide resistance or tolerance polypeptides, vectors comprising those nucleic acid molecules, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and in organisms, including microorganisms and plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, the present invention provides for isolated nucleic acid molecules comprising the nucleotide sequence set forth in SEQ ID NO:1 or 14, a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:2, the herbicide resistance nucleotide sequence deposited in a bacterial host as Accession Nos. NRRL B-30931,... |
| Grg33, grg35, grg36, grg37, grg38, grg39 and grg50: novel epsp synthase genes conferring herbicide resistance | 20070300326 | 20071227 |
| Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include nucleic acid molecules encoding herbicide resistance or tolerance polypeptides, vectors comprising those nucleic acid molecules, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, the present invention provides for isolated nucleic acid molecules comprising the nucleotide sequence set forth in SEQ ID NO:1, 3, 4, 6, 7, 9, 10, 12, 13, 15, 17, 18, 20, 21, or 23, a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:2, 5,... |
| Plant enzymes for bioconversion | 20070300327 | 20071227 |
| The invention provides a method for converting sesquiterpene. The method includes reacting a sesquiterpene substract with a sesquiterpene converting enzyme. The enzyme is from a species or organism containing sesquiterpenes. The sesquiterpene substrate is not naturally present in the species or organism.
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| Calcareous organism growth accelerator | 20070289546 | 20071220 |
| The purpose of this invention is to provide compositions useful for promoting the growth of calcareous organisms present in a closed system aquatic habitat. Particularly, to composition capable of efficiently delivering calcium and carbonate to the calcareous organisms. Most particularly, to a composition effective for enhanced delivery of aragonite to a closed system aquatic habitat where it dissociates into bioavailable supplements, such as, calcium, strontium, magnesium, and carbonate ions, whereby enhanced growth of the calcareous organisms is achieved.
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| Method of reducing volume of sludge and apparatus therefor | 20070289909 | 20071220 |
| The pH value of excess sludge taken out from a biological oxidation tank (2) is adjusted to 8 to 14, and the pH-adjusted sludge is injected into a solubilizing device (3). The sludge taken out from the solubilizing device (3) is heated to 110° C. to 350° C. at a pressure higher than saturated steam pressure to solubilize the sludge to a state readily degradable by microorganisms. The solubilized sludge is returned to a biological oxidizing tank (2), and the pH value of the sludge in the biological oxidizing tank (2) to 5 to 9. The use of the above method of treating excess sludge and an apparatus therefore enables substantially reducing the volume of excess sludge with economic advantage.
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| Filter with at least one membrane sputtering-coated with silver particles | 20070289914 | 20071220 |
| A filter that reduces microorganisms or chlorine from tap water and has at least one membrane that has at least one layer. The at least one layer is a fabric layer sputtering-coated with silver particles.
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| Method of treating waste liquid from production plant for hydrocarbons or oxygen-containing compounds | 20070289923 | 20071220 |
| A method for treating a formaldehyde-containing waste liquid, which is formed as a byproduct in a plant for the production of hydrocarbons or oxygen-containing compounds, containing the steps of: subjecting formaldehyde in the liquid to chemical treatment; and treating the resulting waste liquid, while being aerated, by using a membrane bioreactor that is composed of a microorganism or enzyme and a separation membrane.
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| Method of manufacture of a plate of releasable elements and its assembly into a cassette | 20070292312 | 20071220 |
| A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.
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| Use of viruses and virus-resistant microorganisms for controlling microorganism populations | 20070292395 | 20071220 |
| A lytic virus specific for a target strain of a microorganism and substantially free of undesirable genes may be utilized in processes including control of populations of microorganisms. The virus may include a host-range mutant, or “h-mutant.” A method for generating virus includes growing virus-resistant variants of a target strain of a microorganism in the presence of viruses that are specific for the target strain. Only h-mutant viruses will proliferate. Wild-type virus-resistant and virus-resistant variants of a microorganism are also disclosed, as are methods generating such variants. Methods for controlling target strain microorganisms include introducing virus into a treatment site where control of a population of a target strain microorganism is desired or introducing virus-resistant variants of a microorganism into treatment sites where the presence of... |
| Methods and compositions for producing insulin sensitization | 20070292409 | 20071220 |
| The invention herein provides a mode of treating metabolic syndrome, which includes Type 2 diabetes mellitus and insulin resistance in human and other subjects by identifying and administering an insulin sensitizing compound which modulates GRK2 function in the insulin signaling pathway. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable insulin sensitizing aspects are achieved by various embodiments of the present invention.
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| Method and composition to control the growth of microorganisms in aqueous systems and on substrates | 20060289354 | 20061228 |
| A method and composition for killing, preventing, or inhibiting the growth of microorganisms in an aqueous system or on a substrate capable of supporting a growth of microorganisms are provided by providing a lactoperoxidase, hydrogen peroxide or a peroxide source, a halide, other than a chloride, or a thiocyanate, and, optionally, an ammonium source, under conditions in which the lactoperoxidase, peroxide from the hydrogen peroxide or peroxide source, halide or thiocyanate and ammonium from the ammonium source interact to provide an antimicrobial agent to the aqueous system or substrate.
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| Method for treating ship ballast water | 20060289364 | 20061228 |
| A method for treating ship ballast water in which organisms viable in the ship ballast water are exterminated by adding to the ship ballast water hydrogen peroxide or a compound producing hydrogen peroxide in an amount such that a hydrogen peroxide concentration comes to be 10 to 500 mg/L and at least one type selected from a ferrous ion or a compound supplying ferrous ion in an amount such that a ferrous ion concentration comes to be 0.1 to 400 mg/L, catalase in an amount such that a concentration of catalase comes to be 0.5 to 2,500 unit/L and iodine or a compound supplying iodine amount such that an iodine concentration comes to be 0.1 to 100 mg/L.
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| Cytotoxic factors for modulating cell death | 20060292136 | 20061228 |
| Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
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| Sulfonated styrene polymers for medical articles and barrier web constructs | 20060292208 | 20061228 |
| Sulfonated styrene copolymer compositions and salts thereof, and their use in drug delivery devices, such as wound dressings, as well as their use for controlling chemical agents and for controlling biological organisms are presented.
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| Use of zeolithes for reducing the proportion of lactates and ammonium in human and animal organisms | 20060292242 | 20061228 |
| The invention relates to lowering the lactate values or the ammonium values in the blood of mammals, including humans. According to the invention, ground zeolites are administered orally in the form of a consumption product or a drug. In particular, the zeolite is chosen from the group of natural zeolites such as clinoptilolite, silver zeolite, mordenite, phillipsite, and analcite, and/or from the group of synthetic zeolites such as zeolite A, zeolite W, and zeolite X.
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| Neutralizing agent for toxin of clostridium microorganisms | 20060292247 | 20061228 |
| As a safe and easy-to-use neutralizing agent for toxins of Clostridium microorganisms, a neutralizing agent comprising Thearubigin as its effective component is provided.
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| Treatment to reduce microorganisms with carbon dioxide by multiple pressure oscillations | 20060292274 | 20061228 |
| Apparatus and methods to non-thermally treat goods for human consumption with carbon dioxide. Apparatus and methods rely on multiple pressure changes of carbon dioxide to affect one of three processes. A first process rapidly freezes and thaws water on the surface of the goods in rapid succession multiple times to detrimentally affect pathogens. A second process raises the pressure and temperature of carbon dioxide to supercritical conditions to detrimentally affect the lipids in the membranes of pathogens. A third process adjusts the pressure to form a dense carbon dioxide liquid with a low pH that may also detrimentally affect pathogens. All processes may be repeated or performed in succession, or in any order. Optionally, thereafter, the goods may be stored at low temperature in substantially 100%... |
| Method for optimising gene expressing using synonymous codon optimisation | 20060292566 | 20061228 |
| The present invention discloses a method for modulating the quality of a selected phenotype that is displayed by an organism or part thereof and that results from the expression of a polypeptide-encoding polynucleotide by replacing at least one codon of that polynucleotide with a synonymous codon that has a higher or lower preference of usage by the organism or part thereof to produce the selected phenotype than the codon it replaces. The present invention is also directed to the use of a codon-modified polynucleotide so constructed for modulating the quality of a selected phenotype displayed by an organism or part thereof.
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| Human orthologues of wart | 20060292573 | 20061228 |
| The present invention relates in part to hWART nucleic acid molecules. The invention also relates in part to nucleic acid molecules encoding portions of hWART full-length proteins, nucleic acid vectors containing hWART nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that modulate the function of an hWART polypeptide. Also disclosed are methods for diagnosing abnormal cell proliferative conditions in an organism using hWART-related molecules or compounds.
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| Automated vntr genotyping method | 20060292574 | 20061228 |
| The invention provides an automated VNTR genotyping method using multiple variable-number tandem repeats (VNTRs) loci based on mycobacterial interspersed repetitive units (MIRU) undergoing multiplex PCR and high throughput MegaBACE® capillary electrophoresis system. The method uses fluorescent dyes of 6-carboxytetramethylrhodamine(TAMRA), 6-carboxy fluorescein (FAM) and 6-carboxy-2′,4,4′,5′,7,7′-hexachlorofluorescein (HEX) labeling PCR primers. The method results in an efficient VNTR genotyping with low cost, less labor-requirement and less reaction time. The method is applicable in organism analyses by VNTR genotyping, such as microorganisms, parasites, animals or plants.
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| Assay systems, kits and methods for detecting microorganisms | 20060292588 | 20061228 |
| The present invention relates to an assay system, kits and methods for detecting microorgansims (especially for M. tuberculosis) of suspected patient. The present invention also relates to an apparatus for performing the integration of thermal and magnetic control in the same apparatus to largely reduce the whole process of M. tuberculosis detection is less than 5 hours.
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| Rapid genotyping analysis and the device thereof | 20060292601 | 20061228 |
| The present invention discloses the use of Allele-Specific-oligonucleotide (ASO) as a detection assay for human HLA classification. Using Reversed-Dot-Blotting format and flow through hybridization process, more efficient, faster and less expensive HLA classification can be achieved. A simplified procedure for HLA genotyping is also described. This invention further provides a Single Nucleotide Polymorphism (SNP)-based DNA fingerprining method for rapid and accurate genotyping, identification as well as DNA analyses of genetic data from human beings and different organisms. In addition this invention also discloses a new device for rapid and sensitive analyses of nucleic acids, proteins and other analysts for diagnosis.
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| Compositions and methods for detecting single gene copies in-situ | 20060292615 | 20061228 |
| Compositions and methods are provided for detecting single copies of a gene in-situ using brightfield microscopy in detection of various target nucleic acid sequences, such as genes or nucleic acid of microorganisms in a cell. In particular, nucleic acid probes for various target nucleic acid sequences in a cell are utilized in conjunction with enzymes and their substrates to produce chromogenic composition associated with the target nucleic acid sequences in the cell.
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| Substrate detection assay | 20060292652 | 20061228 |
| Methods and compositions for evaluating nicotinamide-releasing activities as well as cell and organism-based evaluation methods are provided herein.
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| Galleria mellonella derived composition for detecting peptidoglycan, a method for use thereof, and a diagnostic kit containing the same | 20060292662 | 20061228 |
| The present invention relates to a composition for selectively detecting an extremely small amount of peptidoglycan in sample, a preparation method of the composition, and a detection kit for peptidoglycan. It is possible to quantify a small amount of peptidoglycan contained in human blood, tissue, body fluid, water or food, and to diagnose an infection of microorganism with peptidoglycan as a component of cell wall using the composition and the detection kit. In addition, the composition can be applied for a diagnosis reagent of detecting an infection of Gram-positive bacteria in animal or human being in advance, and thus, can be used for the prevention or treatment of food poisonings and bacterial sepsis.
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| Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins | 20060292674 | 20061228 |
| Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of PTS genes in this organism.
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| Cross-beta structures on microbial organisms | 20060292683 | 20061228 |
| The present invention discloses the use of a protease inhibitor in the preparation of a medicament for the treatment of microbial infections. The invention further discloses the use of a compound binding to a cross-β structure or an antibody specific for a cross-β structure in the preparation of a medicament for the treatment of microbial infections. The invention further discloses methods for attenuating microbial pathogens by deleting at least part of a gene encoding a cross-β structure forming protein. The invention also discloses an antimicrobial composition, and a kit for detecting microbial contamination in a solution or a substance.
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| Method of sustained microbial production of hydrogen gas in a bioreactor utilizing an equalization tank | 20060292685 | 20061228 |
| The present invention provides a method of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The method further includes an equalization tank that provides improved control of flow rates, particularly when combining the hydrogen production system with an industrial process such that organic feed material obtained from the industrial process is utilized in the hydrogen production system. The environment in the bioreactor is preferably maintained between about 3.5 and 6.0 pH.
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| Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina) | 20060292691 | 20061228 |
| The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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| Synergistic acidic ternary biocidal compositions | 20060293214 | 20061228 |
| Aqueous dilutions of acidic ternary compositions having unusually synergistic antimicrobial activity against Staphylococcus aureus and Salmonella choleraesuis microorganisms are disclosed. The compositions encompass ternary component mixtures of an alpha-hydroxycarboxylic acid, a monohydric water soluble alkanol and an anionic tenside having a Ternary Ratio residing within a defined phase region wherein synergistic antimicrobial activity is observed; whereas mixtures outside of the defined phase region and those lacking any one of the components do not exhibit synergistic activity. Compositions, methods and articles employing the inventive ternary synergistic compositions, and their utility in sanitizing and disinfecting hard surfaces are described.
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| Preparation for preventing contact of pathogenic matter with living organism | 20060293263 | 20061228 |
| Intermolecular mutual recognition between pathogenic matter, such as allergen group or disease-causing microbe, capable of functioning at the attachment thereof to living organism and a living organism is inhibited by the use of pectins or nucleic acids.
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| Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina) | 20060293271 | 20061228 |
| The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
... |
| Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina) | 20060293272 | 20061228 |
| The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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| Oxazolidinone derivatives as antimicrobials | 20060293307 | 20061228 |
| The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
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| Communication system, communication terminal comprising virtual network switch, and portable electronic device comprising organism recognition unit | 20060294249 | 20061228 |
| The communication terminal of a communication system comprises a virtual network switch which can forcibly alter the destination of data being transmitted/received between the communication terminal and a network. Data is transmitted/received between the network and the communication terminal through a portable electronic device. Various functions, including a security function, can be supplemented by providing the function in software mounted on the portable electronic device. Even if a communication terminal connected directly with the network is not provided with such functions as a VPN, firewall or virus check, high-safety communication is ensured utilizing these security ensuring means mounted on the portable electronic device.
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| Compositions, organisms and methodologies employing a novel human kinase | 20060294601 | 20061228 |
| This invention provides compositions, organisms and methodologies employing a novel human protein kinase, HPK3P23. The novel human kinase has sequence homology to the catalytic domains of several protein kinases. The gene encoding this novel protein kinase is localized in or near the 3p23 locus of the human chromosome 3. The sequence similarity between the novel human protein and the catalytic domain of protein kinases indicates that the novel human protein may function as a protein kinase.
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| Fluid purification system with ultra violet light emitters | 20060283786 | 20061221 |
| A system for purifying a fluid uses ultra violet (UV) light to inactivate micro-organisms present in the fluid. The system has an arrangement of UV light emitters on perforated plates. The fluid, while passing through perforations in the perforated plates, is exposed to the UV light emitted by the UV light emitters. Micro-organisms present in the fluid pass very close to the UV light emitters. The UV light absorbed by the micro-organisms causes genetic damage and inactivation. The system has feedback units providing feedback about the physical properties of the fluid to a power unit supplying power to the UV light emitters. The power unit varies the amount of power supplied to the UV light emitters, based on the feedback.
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| Biological whole cell mass spectrometer | 20060284074 | 20061221 |
| A method for identifying a biological organism that includes providing a biological sample corresponding to the biological organism, ionizing the biological sample to produce an ionized sample of the biological sample, performing a mass spectrometry analysis of the ionized sample, and identifying the biological organism in accordance with the mass spectrometry analysis.
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| Electrically conductive cellulose composite | 20060286434 | 20061221 |
| An electrically conductive cellulose composite includes a cellulose matrix and an electrically conductive carbonaceous material incorporated into the cellulose matrix. The electrical conductivity of the cellulose composite is at least 10 μS/cm at 25° C. The composite can be made by incorporating the electrically conductive carbonaceous material into a culture medium with a cellulose-producing organism, such as Gluconoacetobacter hansenii. The composites can be used to form electrodes, such as for use in membrane electrode assemblies for fuel cells.
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| Time-of-addition assay for identifying anti-viral compounds | 20060286547 | 20061221 |
| The present invention relates to a multi-well assay for identifying a compound inhibiting the replication cycle of a micro-organism, for example, HIV, and to an apparatus for carrying out an assay according to the present invention. The invention further relates to compounds identifiable with an assay according to the invention and pharmaceutical compositions comprising a therapeutically effective amount of such compounds. The identified compounds may be used as medicaments, and in particular for the manufacture of a medicament for treating infectious diseases and in method for treating infectious diseases including AIDS.
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