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Operon patents

      

This page is updated frequently with new Operon-related patent applications.




 Rhamnose promoter expression system patent thumbnailRhamnose promoter expression system
The prokaryotic signal sequence is selected from signal peptides of periplasmatic binding proteins for sugars, amino acids, vitamins and ions. The expression of the nucleic acid sequence is controlled by the promoter region.

 Methods for producing microcompartments patent thumbnailMethods for producing microcompartments
To produce a bacterial microcompartment shell, or a designed shell based on naturally occurring bacterial microcompartment shells in a new host organism, a synthetic operon is constructed that contains the desired shell protein genes and translation efficiency is controlled by host specific ribosomal binding sites. Proteins or other molecules can be encapsulated in the microcompartment shells by various methods described herein.
The Regents Of The University Of California


 Decreased light-harvesting antenna size in cyanobacteria patent thumbnailDecreased light-harvesting antenna size in cyanobacteria
The invention provides methods and compositions for increasing photosynthetic efficiency and biomass production in cyanobacterial cultures by minimizing the phycobilisome light-harvesting antenna size through disruption of the phycocyanin-encoding cpc-operon.. .
The Regents Of The University Of California


 Stabilizied bioactive peptides and methods of identification, synthesis and use patent thumbnailStabilizied bioactive peptides and methods of identification, synthesis and use
An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon.
Peptide Biosciences, Inc.


 Mutated lux operon sequences patent thumbnailMutated lux operon sequences
The present disclosure relates to mutated genes of the lux operon and their use in producing autoluminescent plants and bacteria exhibiting improved light output.. .
Bioglow, L.l.c.


 Production and use of bacterial histamine patent thumbnailProduction and use of bacterial histamine
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine.
Biogaia Ab


 Enhanced protein expression patent thumbnailEnhanced protein expression
The present invention relates in general to bacterial cells having a genetic alteration that results in increased expression of a protein of interest and methods of making and using such cells. Aspects of the present invention include gram positive microorganisms, such as bacillus species, having a genetic alteration that modifies activity of a protein encoded by the ykf operon and results in enhanced expression of a protein of interest..
Danisco Us Inc.


 Method for propagating adenoviral vectors encoding inhibitory gene products patent thumbnailMethod for propagating adenoviral vectors encoding inhibitory gene products
The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetr), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein.
Genvec, Inc.


 Production of magnetic nanoparticles in recombinant host cells patent thumbnailProduction of magnetic nanoparticles in recombinant host cells
The present invention relates to a recombinant host cell, comprising in its genome preferably heterologous gene expression cassettes capable of being expressed in the host cell, the gene expression cassettes encoding a nucleic acid sequence encompassing at least 80% of the full-length sequence of the mamab operon, the mamgdfc operon, and the tmms6 operon of a magnetotactic alphaproteobacterium, respectively, and preferably further comprising gene expression cassettes capable of being expressed in the host cell, the gene expression cassettes encoding a nucleic acid sequence encompassing at least 80% of the full-length sequence of the mamxy operon and/or the feoabi operon of a magnetotactic alphaproteobacterium; wherein the recombinant host cell, upon expression of the gene expression cassettes in their entirety, is capable of producing magnetic nanoparticles. Preferably, the recombinant host cell is derived from rhodospirillum rubrum.
Ludwig-maximilians-universität München


 Methods of using salmonella enterica presenting c. jejuni n-glycan or derivatives thereof patent thumbnailMethods of using salmonella enterica presenting c. jejuni n-glycan or derivatives thereof
The present invention relates to salmonella enterica comprising at least pgl operon of campylobacter jejuni or a functional derivative thereof and presenting at least one n-glycan of campylobacter jejuni or n-glycan derivative thereof on its cell surface and, in particular, to medical uses and pharmaceutical compositions thereof as well as methods for treating and/or preventing campylobacter and optionally salmonella infections and methods for producing these salmonella strains.. .
Eidge-noessische Technische Hochschule Zuriche


Methods and compositions for bacteria infections

Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam.
The University Of Chicago

Method for producing l-leucine, l-valine, l-isoleucine, alpha-ketoisovalerate, alpha-keto-beta-methylvalerate, or alpha-ketoisocaproate using recombinant corynebacteria that contain the ilvbn operon which can be induced by propionate

The invention relates to a process for the production of amino acids and keto acids using microorganisms, in which a promoter inducible by propionate makes possible the regulated expression of certain genes.. .
Evonik Degussa Gmbh

Bacterial mutants with improved transformation efficiency

Provided herein are bacillus mutants having improved transformation efficiency, comprising a disruption of an endogenous epsa-o operon. Also described are methods for producing the mutants, methods for generating transformants using the mutants, and methods for producing a polypeptide or fermentation product using the mutants..
Novozymes A/s

Strain having enhanced l-valine productivity and l-valine production method using the same

The present invention relates to a novel l-valine-producing strain which is transformed so as to strengthen the expression of l-valine operon by having a nucleotide sequence, for coding a leader peptide in a regulatory region of ilvbn operon, entirely deleted, or partially deleted or substituted. In addition, the present invention relates to a method for producing l-valine using the novel l-valine-producing strain.

Allelic disorders caused by mutations in trpv4

The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily v, member 4 (trpv4). In particular, mutations are detected in trpv4 to detect diseases such as scapuloperoneal spinal muscular atrophy (spsma) and hereditary motor and sensory neuropathy type iic (hmsn iic) or charcot-marie-tooth disease type 2c (cmt2c)..

Resistance against hyaloperonospora parasitica in diplotaxis tenuifolia

The invention relates to a rucola plant of the species diplotaxis tenuifolia which may comprise genetic determinant b and optionally a that leads to expression of resistance against at least hyaloperonospora parasitica isolates pp0615 and pp1248, which genetic determinant b is obtainable from a diplotaxis tenuifolia plant which may comprise said genetic determinant, representative seed of which was deposited with the ncimb under deposit number ncimb 42151 and which genetic determinant a is obtainable from a diplotaxis tenuifolia plant which may comprise said genetic determinant, representative seed of which was deposited with the ncimb under deposit number ncimb 41811. The invention further provides seeds that can grow into a plant that is resistant to at least hyaloperonospora parasitica isolates pp0615 and pp1248, to progeny of the rucola plant, to propagation material suitable for producing the plant, to seed and to parts of the plant and food products which may comprise the plant parts..

Attenuated chlamydia vaccine

The invention provides vectors, attenuated pathogens, compositions, methods, and kits for use in preventing or treating infection by an infectious pathogen, especially chlamydia trachomatis. The vectors comprise the plasmid encoded ppg genes from chlamydia, ppg1, ppg2, ppg3, ppg5, ppg6, ppg7 and/or ppg8, but lack ppg4, a regulator of virulence associated genes.
The United States Of America,as Represented By The Secretary, Department Of Health & Human Services

Methods and cell-free microfluidic-assisted biosynthesis

A trans-disciplinary system for cell-free biosynthesis includes a cell-free transcription-translation (tx-tl) tool and modular, generalizable microfluidic architectures. Both components of the system are independently functional and are combinable into a cell-free biosynthesis platform.
Massachusetts Institute Of Technology

Method for bacterial species identification and strain typing

The present disclosure describes a method for identifying a strain or species of bacteria using a single locus sequence typing technique. The single locus useful in the method is the promoter region of the 16s rrna operon.
The Regents Of The University Of Michigan

Modified bacteria for the production of bioalcohol

The present invention provides a modified bacterial strain capable of fermenting both hexose and pentose sugars for production of bioalcohol wherein a promoter of pyruvate dehydrogenase operon (pdh) is replaced with a promoter of a gene that is expressed under anaerobic conditions. The present invention further provides a method of obtaining modified bacterial strain capable of fermenting both hexose and pentose sugar for production of bioalcohol.
International Centre For Genetic Engineering And Biotechnology (icgeb)

Antibiotic methods and compositions for bacteria infections

Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam.

Method for producing l-amino acid

A method for producing of an l-amino acid is provided. An l-amino acid is produced by culturing a bacterium belonging to the family enterobacteriaceae and having an l-amino acid-producing ability, which has been modified so that the acpp-fabf operon is attenuated, in a medium, and collecting the l-amino acid from the medium or cells of the bacterium..
Ajinomoto Co., Inc.

Bacteriophages for use against bacterial infections

The present invention relates to a composition comprising obligate lytic bacteriophages generated by a method comprising subjecting normally in vivo lysogenic, pseudolysogenic or temperate bacteriophages to genetic modifications in vitro, which alters the biological activity of one or more of the individual gene products for establishing, maintaining, controlling or regulating the lysogenic life cycle of the bacteriophages, thereby converting them to obligate lytic bacteriophages, wherein the genetic modification includes modification of a single gene in the operon containing a gene resulting in a gene product for establishing, maintaining, controlling or regulating the lysogenic life cycle of the bacteriophages.. .

Microorganism of the genus escherichia having enhanced l-tryptophan productivity and a producing l-tryptophan using the same

The present invention relates to microorganisms of escherichia coli having enhanced l-tryptophan productivity and to a method for producing l-tryptophan using the same. More particularly, the present invention relates to an escherichia coli variant in which repression and attenuation control of the tryptophan operon is released and accumulation of anthranilate is reduced and thereby enhancing l-tryptophan productivity.
Cj Cheiljedang Corporation

Metabolic engineering of the shikimate pathway

The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to recombinant nucleic acids encoding operons that increase production of aromatic amino acids and the aromatic amino acid intermediate shikimate; microorganisms with increased production of aromatic amino acids and the aromatic amino acid intermediate shikimate; and methods related to the production of aromatic amino acids, the aromatic amino acid intermediate shikimate, and commodity chemicals derived therefrom..
The Regents Of The University Of Califonia

Constructs and producing microcompartments

To produce a bacterial microcompartment shell, or a designed shell based on naturally occurring bacterial microcompartment shells in a new host organism, a synthetic operon is constructed that contains the desired shell protein genes and translation efficiency is controlled by host specific ribosomal binding sites. Proteins or other molecules can be encapsulated in the microcompartment shells by various methods described herein.
The Regents Of The University Of California

Crystal structure of the nanr and mannac-6p complex, and uses thereof

The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of nanr which is a key pathogenic regulatory protein of vibrio vulnificus and manna6p which is a nanr regulator. Further, the present invention relates to a modified nanr protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector.
Korea Research Institute Of Bioscience And Biotechnology

Genetically modified clostridium thermocellum engineered to ferment xylose

One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals.
Mascoma Corporation

Microorganism for simultaneously producing l-amino acid and riboflavin, and producing l-amino acid and riboflavin using same

The present invention relates to a method for producing highly-concentrated l-amino acid and riboflavin simultaneously, and a microorganism for simultaneously producing l-amino acid and riboflavin. Specifically, the present invention relates to a modified microorganism for producing l-lysine or l-threonine, and riboflavin simultaneously, wherein the microorganism belonging to corynebacterium sp.

Programmable modification of dna

A self-reconfiguring genome uses a cassette having operons or dna sequences that code for guide rna, reverse transcriptase, donor rna, and a crispr cleavage enzyme. A self-reconfiguring genome may be based on lambda recombineering of in situ generated oligonucleotides.

Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides

The present invention relates to mutated and/or transformed microorganisms for the synthesis of various compounds. More specifically, the present invention discloses microorganisms mutated in the genes encoding for the regulators arca and iclr.

Compositions, kits, and related methods for detecting and/or monitoring shiga toxin producing escherichia coli

Ecf, such as the ecf operon/gene cluster (e.g., ecf2-1- and ecf2-2 described herein) may be used to detect virulent stecs including virulent non-0157:h7 stec and virulent non-0157:h7 ehec. Use of this nucleic acid target, in combination with other targets, such as z5866, rfb0157, wzx0157, wzy0157, z0344, z0372, sil0157, and katp junction provides a robust, sensitive assay for distinguishing 0157:h7 from virulent non-0157:h7 stec.

Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms

The present invention relates to polynucleotides from cochliobolus heterostrophus c5, cyanothece sp. Ccy0110, mycocentrospora acerin and hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids.

Growth enhancement of plants

The present invention provides means and methods for producing plants with enhanced growth and yield. Particularly, the present invention provides plants to which an expression construct comprising the entire prn operon was introduced, wherein said plants produce pyrrolnitrin and show enhanced growth and yield production compared to corresponding control plants not harboring the prn operon..

Modified bordetella pertussis strains

Recombinant bordetella pertussis strains derived from parent strain tohama are provided. The new strains are obtained by homologous recombination using a allelic exchange vector pss4245, which allows the replacement of sections of the bacterial chromosome without leaving any accessory mutations.

Stable genomic integration of multiple polynucleotide copies

Methods of constructing a cell comprising in its chromosome one or more copies of an open reading frame (orf) or operon encoding at least one polypeptide of interest, each copy being under the transcriptional control of a heterologous promoter using a site specific recombinase and in vivo integration by recombination; means for carrying out the methods, resulting cells, and methods for producing a polypeptide of interest using the resulting cells.. .

Method for propagating adenoviral vectors encoding inhibitory gene products

The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetr), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein.

Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation

Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established.

Stabilized bioactive peptides and methods of identification, synthesis, and use

An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon.

Method for producing an l-amino acid belonging to the glutamate family, using a coryneform bacterium

The present invention provides a method for producing an l-amino acid belonging to the glutamate family, using a coryneform bacterium which has been modified so that expression of one or more gene(s) of the ncgl_2067-ncgl_2065 operon in said bacterium is/are attenuated.. .

Methods for producing hyaluronan in a recombinant host cell

The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign to the hyaluronan synthase encoding sequence; and (b) recovering the hyaluronic acid from the cultivation medium. The present invention also relates to an isolated nucleic acid sequence encoding a hyaluronan synthase operon comprising a hyaluronan synthase gene and a udp-glucose 6-dehydrogenase gene, and optionally one or more genes selected from the group consisting of a udp-glucose pyrophosphorylase gene, udp-n-acetylglucosamine pyrophosphorylase gene, and glucose-6-phosphate isomerase gene.

Solid state drive memory device comprising secure erase function

A memory device such as a solid state memory device have a dual-hardware, secure erase feature. A memory controller operating in a memory controller domain provides general memory management and interface operons.



Operon topics:
  • Recombinant
  • Prophylaxis
  • Lactic Acid
  • Antibiotic
  • Pantothenic Acid
  • Prokaryotic
  • Neuropathy
  • Muscular Atrophy
  • Tooth Disease
  • Spinal Muscular Atrophy
  • Ion Channel
  • Hereditary Motor And Sensory Neuropathy
  • Repressor Gene
  • Oncolytic Viruses
  • Smallpox Vaccine


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    This listing is a sample listing of patent applications related to Operon for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Operon with additional patents listed. Browse our RSS directory or Search for other possible listings.


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