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|| List of recent Operon-related patents
|Method for producing an l-amino acid belonging to the glutamate family, using a coryneform bacterium|
The present invention provides a method for producing an l-amino acid belonging to the glutamate family, using a coryneform bacterium which has been modified so that expression of one or more gene(s) of the ncgl_2067-ncgl_2065 operon in said bacterium is/are attenuated.. .
|Methods for producing hyaluronan in a recombinant host cell|
The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign to the hyaluronan synthase encoding sequence; and (b) recovering the hyaluronic acid from the cultivation medium. The present invention also relates to an isolated nucleic acid sequence encoding a hyaluronan synthase operon comprising a hyaluronan synthase gene and a udp-glucose 6-dehydrogenase gene, and optionally one or more genes selected from the group consisting of a udp-glucose pyrophosphorylase gene, udp-n-acetylglucosamine pyrophosphorylase gene, and glucose-6-phosphate isomerase gene.
|Solid state drive memory device comprising secure erase function|
A memory device such as a solid state memory device have a dual-hardware, secure erase feature. A memory controller operating in a memory controller domain provides general memory management and interface operons.
|Non-toxic solvent for chromogenic substrate solution and uses thereof|
The present invention relates to a non-toxic dipolar solvent for chromogenic substrate for detecting presence of lacz gene and/or gene activity, which comprises a stabilizing amount of a solubilizing agent. The present invention also relates to a method for inducing lac operon in screening assay, comprising the step of contacting an agar plate with at least one essential oil in a concentration sufficient to induce the lac operon.
|Allelic disorders caused by mutations in trpv4|
The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily v, member 4 (trpv4). In particular, mutations are detected in trpv4 to detect diseases such as scapuloperoneal spinal muscular atrophy (spsma) and hereditary motor and sensory neuropathy type iic (hmsn iic) or charcot-marie-tooth disease type 2c (cmt2c)..
|Inducible and repressible vaccinia viruses with improved safety|
Described herein are recombinant vaccinia viruses that provide the efficacy of the current smallpox vaccine, but with a built-in safety mechanism, giving the physician or vaccine recipient (vaccinee) control over the vaccine virus replication. Specifically, genetic elements of the tetracycline (tet) operon and modified tet repressor genes are used to control the expression of vaccinia virus genes that are essential for viral replication, thereby allowing replication of the virus to be accurately regulated through the addition or removal of antibiotics (tetracyclines).
|Production and use of bacterial histamine|
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an.
|Bioinformatically detectable group of novel viral regulatory genes and uses thereof|
The present invention relates to a group of novel viral rna regulatory genes, here identified as “viral genomic address messenger genes” or “vgam genes”, and as “genomic address genes” or “gr” genes. Vgam genes selectively inhibit translation of known host target genes, and are believed to represent a novel pervasive viral attack mechanism.
|Bacteriophages for use against bacterial infections|
The present invention relates to a composition comprising obligate lytic bacteriophages generated by a method comprising subjecting normally in vivo lysogenic, pseudolysogenic or temperate bacteriophages to genetic modifications in vitro, which alters the biological activity of one or more of the individual gene products for establishing, maintaining, controlling or regulating the lysogenic life cycle of the bacteriophages, thereby converting them to obligate lytic bacteriophages, wherein the genetic modification includes modification of a single gene in the operon containing a gene resulting in a gene product for establishing, maintaining, controlling or regulating the lysogenic life cycle of the bacteriophages.. .
|Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation|
Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established.
|Pantothenic acid biosynthesis in zymomonas|
Zymomonas is unable to synthesize pantothenic acid and requires this essential vitamin in growth medium. Zymomonas strains transformed with an operon for expression of 2-dehydropantoate reductase and aspartate 1-decarboxylase were able to grow in medium lacking pantothenic acid.
|Autoluminescent plants including the bacterial lux operon and methods of making same|
In one aspect, the invention relates to a transgenic autoluminescent plant including an expressible heterologous nucleotide sequence comprising a bacterial lux operon, which includes lux a. Lux b.
|Production and use of bacterial histamine|
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine.
|Streptococcus thermophilus bacterium|
The present invention provides an improved streptococcus thermophilus. The invention is based on the surprising finding that a putative lantibiotic operon in streptococcus thermophilus is required for community formation.
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Operon topics: Recombinant, Prophylaxis, Lactic Acid, Antibiotic, Pantothenic Acid, Prokaryotic, Neuropathy, Muscular Atrophy, Tooth Disease, Spinal Muscular Atrophy, Ion Channel, Hereditary Motor And Sensory Neuropathy, Repressor Gene, Oncolytic Viruses, Smallpox Vaccine
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