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Operon patents



      
           
This page is updated frequently with new Operon-related patent applications. Subscribe to the Operon RSS feed to automatically get the update: related Operon RSS feeds. RSS updates for this page: Operon RSS RSS


Date/App# patent app List of recent Operon-related patents
02/12/15
20150044734
 Metabolic engineering of the shikimate pathway patent thumbnailMetabolic engineering of the shikimate pathway
The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to recombinant nucleic acids encoding operons that increase production of aromatic amino acids and the aromatic amino acid intermediate shikimate; microorganisms with increased production of aromatic amino acids and the aromatic amino acid intermediate shikimate; and methods related to the production of aromatic amino acids, the aromatic amino acid intermediate shikimate, and commodity chemicals derived therefrom..
The Regents Of The University Of Califonia
01/22/15
20150026840
 Constructs and  producing microcompartments patent thumbnailConstructs and producing microcompartments
To produce a bacterial microcompartment shell, or a designed shell based on naturally occurring bacterial microcompartment shells in a new host organism, a synthetic operon is constructed that contains the desired shell protein genes and translation efficiency is controlled by host specific ribosomal binding sites. Proteins or other molecules can be encapsulated in the microcompartment shells by various methods described herein.
The Regents Of The University Of California
01/08/15
20150010915
 Crystal structure of the nanr and mannac-6p complex, and uses thereof patent thumbnailCrystal structure of the nanr and mannac-6p complex, and uses thereof
The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of nanr which is a key pathogenic regulatory protein of vibrio vulnificus and manna6p which is a nanr regulator. Further, the present invention relates to a modified nanr protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector.
Korea Research Institute Of Bioscience And Biotechnology
12/18/14
20140370561
 Genetically modified clostridium thermocellum engineered to ferment xylose patent thumbnailGenetically modified clostridium thermocellum engineered to ferment xylose
One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals.
Mascoma Corporation
12/04/14
20140356518
 Microorganism for simultaneously producing l-amino acid and riboflavin, and  producing l-amino acid and riboflavin using same patent thumbnailMicroorganism for simultaneously producing l-amino acid and riboflavin, and producing l-amino acid and riboflavin using same
The present invention relates to a method for producing highly-concentrated l-amino acid and riboflavin simultaneously, and a microorganism for simultaneously producing l-amino acid and riboflavin. Specifically, the present invention relates to a modified microorganism for producing l-lysine or l-threonine, and riboflavin simultaneously, wherein the microorganism belonging to corynebacterium sp.
11/27/14
20140349400
 Programmable modification of dna patent thumbnailProgrammable modification of dna
A self-reconfiguring genome uses a cassette having operons or dna sequences that code for guide rna, reverse transcriptase, donor rna, and a crispr cleavage enzyme. A self-reconfiguring genome may be based on lambda recombineering of in situ generated oligonucleotides.
11/27/14
20140349348
 Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides patent thumbnailMutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides
The present invention relates to mutated and/or transformed microorganisms for the synthesis of various compounds. More specifically, the present invention discloses microorganisms mutated in the genes encoding for the regulators arca and iclr.
11/20/14
20140342362
 Compositions, kits, and related methods for detecting and/or monitoring shiga toxin producing escherichia coli patent thumbnailCompositions, kits, and related methods for detecting and/or monitoring shiga toxin producing escherichia coli
Ecf, such as the ecf operon/gene cluster (e.g., ecf2-1- and ecf2-2 described herein) may be used to detect virulent stecs including virulent non-0157:h7 stec and virulent non-0157:h7 ehec. Use of this nucleic acid target, in combination with other targets, such as z5866, rfb0157, wzx0157, wzy0157, z0344, z0372, sil0157, and katp junction provides a robust, sensitive assay for distinguishing 0157:h7 from virulent non-0157:h7 stec.
11/13/14
20140335579
 Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms patent thumbnailDesaturases and process for the production of polyunsaturated fatty acids in transgenic organisms
The present invention relates to polynucleotides from cochliobolus heterostrophus c5, cyanothece sp. Ccy0110, mycocentrospora acerin and hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids.
10/30/14
20140325707
 Growth enhancement of plants patent thumbnailGrowth enhancement of plants
The present invention provides means and methods for producing plants with enhanced growth and yield. Particularly, the present invention provides plants to which an expression construct comprising the entire prn operon was introduced, wherein said plants produce pyrrolnitrin and show enhanced growth and yield production compared to corresponding control plants not harboring the prn operon..
10/09/14
20140302558

Modified bordetella pertussis strains


Recombinant bordetella pertussis strains derived from parent strain tohama are provided. The new strains are obtained by homologous recombination using a allelic exchange vector pss4245, which allows the replacement of sections of the bacterial chromosome without leaving any accessory mutations.
09/18/14
20140273237

Stable genomic integration of multiple polynucleotide copies


Methods of constructing a cell comprising in its chromosome one or more copies of an open reading frame (orf) or operon encoding at least one polypeptide of interest, each copy being under the transcriptional control of a heterologous promoter using a site specific recombinase and in vivo integration by recombination; means for carrying out the methods, resulting cells, and methods for producing a polypeptide of interest using the resulting cells.. .
09/18/14
20140273228

Method for propagating adenoviral vectors encoding inhibitory gene products


The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetr), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein.
07/24/14
20140206054

Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation


Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established.
04/17/14
20140106341

Stabilized bioactive peptides and methods of identification, synthesis, and use


An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon.
02/20/14
20140051132

Method for producing an l-amino acid belonging to the glutamate family, using a coryneform bacterium


The present invention provides a method for producing an l-amino acid belonging to the glutamate family, using a coryneform bacterium which has been modified so that expression of one or more gene(s) of the ncgl_2067-ncgl_2065 operon in said bacterium is/are attenuated.. .
02/06/14
20140038235

Methods for producing hyaluronan in a recombinant host cell


The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign to the hyaluronan synthase encoding sequence; and (b) recovering the hyaluronic acid from the cultivation medium. The present invention also relates to an isolated nucleic acid sequence encoding a hyaluronan synthase operon comprising a hyaluronan synthase gene and a udp-glucose 6-dehydrogenase gene, and optionally one or more genes selected from the group consisting of a udp-glucose pyrophosphorylase gene, udp-n-acetylglucosamine pyrophosphorylase gene, and glucose-6-phosphate isomerase gene.
01/23/14
20140022849

Solid state drive memory device comprising secure erase function


A memory device such as a solid state memory device have a dual-hardware, secure erase feature. A memory controller operating in a memory controller domain provides general memory management and interface operons.
11/28/13
20130316330

Non-toxic solvent for chromogenic substrate solution and uses thereof


The present invention relates to a non-toxic dipolar solvent for chromogenic substrate for detecting presence of lacz gene and/or gene activity, which comprises a stabilizing amount of a solubilizing agent. The present invention also relates to a method for inducing lac operon in screening assay, comprising the step of contacting an agar plate with at least one essential oil in a concentration sufficient to induce the lac operon.
07/18/13
20130183671

Allelic disorders caused by mutations in trpv4


The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily v, member 4 (trpv4). In particular, mutations are detected in trpv4 to detect diseases such as scapuloperoneal spinal muscular atrophy (spsma) and hereditary motor and sensory neuropathy type iic (hmsn iic) or charcot-marie-tooth disease type 2c (cmt2c)..
07/04/13
20130171189

Inducible and repressible vaccinia viruses with improved safety


Described herein are recombinant vaccinia viruses that provide the efficacy of the current smallpox vaccine, but with a built-in safety mechanism, giving the physician or vaccine recipient (vaccinee) control over the vaccine virus replication. Specifically, genetic elements of the tetracycline (tet) operon and modified tet repressor genes are used to control the expression of vaccinia virus genes that are essential for viral replication, thereby allowing replication of the virus to be accurately regulated through the addition or removal of antibiotics (tetracyclines).
06/13/13
20130149291

Production and use of bacterial histamine


A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an.
05/23/13
20130130231

Bioinformatically detectable group of novel viral regulatory genes and uses thereof


The present invention relates to a group of novel viral rna regulatory genes, here identified as “viral genomic address messenger genes” or “vgam genes”, and as “genomic address genes” or “gr” genes. Vgam genes selectively inhibit translation of known host target genes, and are believed to represent a novel pervasive viral attack mechanism.
05/16/13
20130121967

Bacteriophages for use against bacterial infections


The present invention relates to a composition comprising obligate lytic bacteriophages generated by a method comprising subjecting normally in vivo lysogenic, pseudolysogenic or temperate bacteriophages to genetic modifications in vitro, which alters the biological activity of one or more of the individual gene products for establishing, maintaining, controlling or regulating the lysogenic life cycle of the bacteriophages, thereby converting them to obligate lytic bacteriophages, wherein the genetic modification includes modification of a single gene in the operon containing a gene resulting in a gene product for establishing, maintaining, controlling or regulating the lysogenic life cycle of the bacteriophages.. .
04/25/13
20130102044

Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation


Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established.
03/28/13
20130078694

Pantothenic acid biosynthesis in zymomonas


Zymomonas is unable to synthesize pantothenic acid and requires this essential vitamin in growth medium. Zymomonas strains transformed with an operon for expression of 2-dehydropantoate reductase and aspartate 1-decarboxylase were able to grow in medium lacking pantothenic acid.
03/21/13
20130074221

Autoluminescent plants including the bacterial lux operon and methods of making same


In one aspect, the invention relates to a transgenic autoluminescent plant including an expressible heterologous nucleotide sequence comprising a bacterial lux operon, which includes lux a. Lux b.
01/24/13
20130022586

Production and use of bacterial histamine


A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine.
01/03/13
20130004616

Streptococcus thermophilus bacterium


The present invention provides an improved streptococcus thermophilus. The invention is based on the surprising finding that a putative lantibiotic operon in streptococcus thermophilus is required for community formation.


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Operon topics: Recombinant, Prophylaxis, Lactic Acid, Antibiotic, Pantothenic Acid, Prokaryotic, Neuropathy, Muscular Atrophy, Tooth Disease, Spinal Muscular Atrophy, Ion Channel, Hereditary Motor And Sensory Neuropathy, Repressor Gene, Oncolytic Viruses, Smallpox Vaccine

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