|| List of recent Onset-related patents
| Olfactory receptor copy number association with age at onset of alzheimer's disease|
The present invention concerns determination of risk for an early age of onset for alzheimer's disease in an individual. In specific embodiments, it concerns identification of copy number at chromosome 14q11.2 or a region thereof and associating a high copy number with an earlier age of onset of alzheimer's disease..
| Enhancing aqm to combat wireless losses|
In order to maintain a small, stable backlog at an internet router buffer, active queue management (aqm) algorithms drop packets probabilistically at the onset of congestion. This causes transmission control protocol (tcp) data flow rates to reduce.
|Methods of diagnosing acute cardiac disorders using bnp-sp|
The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring bnp signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.. .
|Doped low-temperature phase barium metaborate single crystal, the manufacturing method thereof and wave changing elements therefrom|
The present invention relates generally to the field of synthetic crystal, and more particularly, this invention relates to doped low-temperature phase barium metaborate single crystal, growth method and frequency-converter. Molten salt method was adopted.
|Method and system for engine control|
Methods and systems are provided for a vehicle engine. One example method comprises delivering a first fuel to an engine cylinder at least partially during an intake stroke, and initiating combustion in the cylinder via injection of a second fuel into the cylinder.
|Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies|
Antibodies and fragments thereof have high affinity for human α-synuclein protofibrils and low binding of α-synuclein monomers, wherein the antibodies or fragments have specified complementarity determining region (cdr) sequences. Compositions comprise such an antibody or fragment and methods of detecting α-synuclein protofibrils use such an antibody or fragment.
|Low phosphorous oxygen scavenging compositions requiring no induction period|
The present invention provides a composition comprising: a polyester base polymer; at least one non-polymeric oxidizable organic compound; at least one transition metal in a positive oxidation state, said metal being present in the composition in an amount of from about 10 to about 400 ppm, wherein the polyester base polymer comprises less than about 40 ppm phosphorous. The compositions of the present invention do not exhibit an induction period prior to the onset of oxygen scavenging upon formation into a container..
|Nickel-free stainless steel stent|
A nickel-free stainless steel stent using a stainless steel which does not substantially contain ni in the stainless steel, has a metal allergy onset-preventing effect, and is excellent in terms of precision workability, strength, and ductility, is provided. The nickel-free stainless steel stent is characterized by using a stainless steel containing, as a chemical composition, from 15 to 30% by mass of cr, from 0.97 to 2% by mass of mo, and from 0.5 to 1% by mass of n, with the remainder being fe, and optionally containing inevitable impurities..
|Composition for preventing and treating mastitis|
The purpose of the present invention is to reduce the amounts of nitrate nitrogen and ammonia, which can be absorbed through the digestive tract and are factors for causing mastitis in livestock animals, thereby reducing the incidence rate of mastitis. A composition for preventing and treating mastitis for livestock animals comprises a rock powder containing silicic acid and aluminum oxide as active ingredients.
|Retinal fundus surveillance method and apparatus|
A method and apparatus for quantitative imaging of the retinal fundus. The method for retinal health assessment comprises imaging the retinal fundus of a patient's eye at different wavelengths within a spectral range and determining spectral reflectivity of the retina for each pixel within a field of view (fov).
|Universal website preference management|
Systems, apparatus, methods, and computer program products for universal user website preference management. The invention provides for a user to define website preferences that will be applied universally across multiple websites.
|Method and system of longitudinal detection of dementia through lexical and syntactic changes in writing|
The present invention is a method and system for detecting linguistic markers as signs and indicators of mental illness, even prior to onset of symptoms of the mental illness. The linguistic markers may be detected in diachronic analyses of writing or speech samples.
|Method for producing exfoliated graphite-polymer composite material|
Provided is a production method which can attain exfoliating treatment of graphite and a process of grafting a polymer onto exfoliated graphite simultaneously and thus makes it possible to easily obtain an exfoliated graphite-polymer composite material in a short time. A method for producing an exfoliated graphite-polymer composite material includes a step of mixing graphite or primary exfoliated graphite, a depolymerizable monomer of which the polymer is decomposed by heating to generate radicals and also to form a monomer or an oligomer, or the polymer a of the monomer, or a polymer b which forms radicals at a temperature close to its decomposition temperature to obtain a mixture; and a heating step of putting the mixture in a non-open container to heat the mixture to a first temperature range from the ceiling temperature or higher to the onset decomposition temperature or lower, or to a temperature higher than the first temperature range..
|Non-nucleoside reverse transcriptase inhibitors|
Are hiv reverse transcriptase inhibitors, wherein r1, r2, r3, r4 and r5 are defined herein. The compounds of formula i and their pharmaceutically acceptable salts are useful in the inhibition of hiv reverse transcriptase, the prophylaxis and treatment of infection by hiv and in the prophylaxis, delay in the onset or progression, and treatment of aids.
|Methods and compositions for the treatment of metabolic disorders|
Embodiments described herein are directed to methods for the treatment and control of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, including atherosclerosis and non-insulin dependent diabetes. In addition, embodiments are directed to methods of treating coronary heart disease and metabolic syndrome.
|Nanoparticles in the shape of nanosnowman with a head part and a body part, a preparation method thereof and a detection method using the same|
The present invention relates to nanoparticles in the shape of nanosnowman with a head part and a body part, a preparation method thereof, and a detection method using the same. More particularly, the present invention relates to nanoparticles in the shape of nanosnowman with head and body parts, which can offer platforms for dna-based assembly of various aligned and unconventional nanostructures and is highly applicable to the detection of dna and an analyte associated with the onset and progression of a particular disease, a preparation method thereof, and a detection method using the same..
A composition of an olfactory stimulus mechanism for stimulating the production of testosterone. A method of increasing the level of testosterone in an individual by smelling the truffle extract, causing androgens in the truffle extract to attach to the olfactory bulb in the individual, and inducing testosterone production.
|Signatures of electroencephalographic oscillations|
The present invention provides, in some aspects, methods for identifying and evaluating signatures in electroencephalographic oscillations that occur during onset of an exploratory activity in a subject.. .
|Patient condition detection and mortality|
When prediction onset of a medical condition for a patient, multiple sources of knowledge (112) are aggregated and modeled into a format that is usable by multiple algorithms including an inference algorithm (134), a bayesian network (136), and a state machine (138). The outputs (116) of the multiple algorithms are then combined to more accurately predict condition onset.
|Pacing sequence optimization|
An implantable medical device is connected to a multipolar lv lead and an implantable sensor. The sensor signal from the sensor is used to identify a time point of mitral valve closure for a cardiac cycle when a ventricular pulse generator generates pacing pulses that are applied to the electrodes of the multipolar lv lead according to a pacing sequence.
|Recombinant vaccinia virus having hemagglutinin protein genes derived from novel influenza viruses|
Provided are a highly-safe recombinant vaccinia virus that is effective in preventing the onset of symptoms due to infection by novel influenza viruses, and a vaccine for the novel influenza viruses containing the recombinant vaccinia virus. This recombinant vaccinia virus is capable of expressing the hemagglutinin protein genes of the novel influenza virus.
|Time resolved optical microscopy ("trom") process for measuring the rate of crystallization of solid inks|
A system is disclosed for measuring the crystallization of crystalline-amorphous mixtures. The system includes a sample holder.
|Anti-blooming circuit for integrating photodiode pre-amplifiers|
An input clamping circuit of a photo detector preamplifier is activated when an input transistor is turned off by an input overload, and the drain voltage of the input transistor is pulled toward ground by a current source. Even with extreme overloads, the operating conditions (vgs and id) of the input transistor remain within normal range.
|Drug delivery system and method for conscious sedation/analgesia|
Inhalant anesthetics are developed with a number of properties including rapid onset and recovery, controllability, and, ideally, a broad safety profile. The efficacy of these agents is measured by their ability to create anesthesia within the framework of the other desirable properties.
|Monitoring a condition of a subject|
A method of predicting an onset of apnea is described. Motion of a subject, including at least breathing-related motion, is sensed, and a signal corresponding to the sensed motion is generated.
|Compositions and their uses directed to huntingtin|
Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing huntington's disease (hd) progression using an antisense compound targeted to huntingtin.
Or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula i′, processes for preparing compounds of formula i′, intermediates useful for preparing compounds of formula i′ and therapeutic methods for treating the proliferation of the hiv virus, treating aids or delaying the onset of aids or arc symptoms in a mammal are also provided..
|Biomarkers for the diagnosis of als|
Methods for determining the onset of als in a subject are provided. One method includes analyzing a sample obtained from the subject for the presence or amount of one or more biomarkers indicative of als.
|Estriol therapy for multiple sclerosis and other autoimmune diseases|
The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, more particularly, th1-mediated (cell-mediated) autoimmune diseases including: multiple sclerosis (ms), rheumatoid arthritis (ra), autoimmune thyroiditis and uveitis. Most preferably the invention is used to treat a patient with a therapeutically effective amount of estriol of 8 milligrams once daily via oral administration to treat the symptoms or prevent the onset of multiple sclerosis..
|Method for treating type 1 diabetes|
The invention relates to use of the natural cytotoxicity receptor nkp46 for preventing and treating diabetes, including type i diabetes (tid) and type 2 diabetes. In particular, the invention provides compositions comprising a fragment of the extracellular region of nkp46 for preventing the onset and progression of diabetes..
|Media recorder that selects when to record media content that is available at multiple times|
A particular method includes receiving program data designating media content to be recorded at a media recorder. An electronic program guide accessible to the media recorder includes multiple scheduled delivery times for the media content.
|Systems and methods for detecting the onset of compressor stall|
Embodiments of the present application include a stall detection system for a gas turbine engine. The system may include a compressor and a number of variable stator vanes associated with the compressor.
|Comprehensive glaucoma determination method utilizing glaucoma diagnosis chip and deformed proteomics cluster analysis|
Provided is a technique for determining a physiological attribute in a mammal, including the onset or progression of human glaucoma, with high accuracy. The results of the determination of genotype date and the results of the determination of cytokine date are consolidated by a consolidated determination unit (114); comparison is made for determining as to which is larger, the number of case determination procedures or the number of control determination procedures (s330); and it is determined as case (glaucoma) when the number of case determination procedures is larger and it is determined as control (normal person) when the number of control determination procedures is larger..
|System and method for disease diagnosis through iterative discovery of symptoms using matrix based correlation engine|
A system and method for disease diagnosis through iterative discovery of symptoms using matrix based correlation engine. The dialog manager uses the correlation engine to drive the dialogue with the user and presents optimum number of right questions based on which the system correlates and identifies probable disease (s) and the symptom (s) that has the maximum potential to narrow down the search, so as to reach a particular conclusion on disease type.
|Flux saturation controller|
Transformer flux is monitored to determine if an onset of flux saturation is detected. If flux saturation is not detected, the transformer drive signal is received to a switch that maintains the polarity of the transformer flux.
|Models for diagnosis, prevention and treatment of alzheimer's disease|
A transgenic fly whose genome is modified to express enhanced levels of glutamate-cysteine ligase (gcl) gene is provided. The fly displays phenotypes associated with alzheimer's disease (ad).
|Method, apparatus and computer program product for predicting ventricular tachyarrhythmias|
A method, apparatus, and computer program product for predicting ventricular tachyarrhythmia (vta) are disclosed. To provide a mechanism that allows prediction of vta events efficiently within a few hours before the onset of the actual event, a set of repolarization parameters indicative of ventricular repolarization in a subject's heart is determined in successive time segments, thereby to obtain a time series of the set of repolarization parameters.
|Highly sensitive biomarker panels|
Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of chf in plasma.
|Neuropeptide y treatment of autoimmune disease|
The present invention provides a method for treating or delaying the onset of an autoimmune condition in a human subject comprising orally administering to the subject at an effective dose of neuropeptide y.. .
|System and method for appliance activation and deactivation in accordance with religious observance|
The invention consists of an electrical circuit having an internal cpu with clock, and means for switching external loads. By means of the cpu, clock, and possibly internal lookup tables, times during which certain circuits are to be switched off or on are determined.
|Monitoring or predicting system and method of monitoring or predicting|
A monitoring or predicting system to detect the onset of a neurological episode, the system comprising: a neurological electrical input, the input being a digital representation of a neurologically derived signal; a converter to convert the digital signal into a digital data string; a pattern analyser to identify recurring patterns in the digital data string; and a monitor to measure a pattern-derived parameter, wherein an output from the monitor gives an indication of the onset or occasion of a neuronal activity in dependence on the pattern-derived parameter.. .
|System and methods of acoustical screening for obstructive sleep apnea during wakefulness|
A system and methods using tracheal sound intensity variations to screen patients suspected of obstructive sleep apnea during wakefulness. The system includes a mechanism positioning the patient and a sound input device attached to a recording device to receive breathing sound signals.