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|| List of recent Omeprazole-related patents
|Crystalline s-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same|
Disclosed are a crystalline s-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, thermostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.. .
|Process for the preparation of esomeprazole magnesium dihydrate|
A process for preparing form a of (s)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1h-benzimidazole magnesium dihydrate, processes for preparing various intermediates useful in the preparation of form a of (s)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1h-benzimidazole magnesium dihydrate and a novel polymorphic form ii of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]thio]-1h-benzimidazole.. .
|Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals: oxidation of coordinated benzimidazole to omeprazole|
The present invention is directed to a process for the catalytic oxidation of the thioether 5-methoxy-2-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)methylthio)-1h-benzimidazole to its sulfoxide: 5-methoxy-2-((4-methoxy-3,5-dimethyl-2-pyridinyl) methyl) methylsulfinyl)-1h-benzimidazole comprising: reacting the thioether with: 1) a transition metal catalyst; and, 2) an oxygen source; wherein the thioether is oxidized to the sulfoxide commonly known as omeprazole and wherein one of either the r and s enantiomers is formed to an enantiomeric excess.. .
|Pharmaceutical compositions of nsaid and acid inhibitor|
The present invention relates a pharmaceutical composition comprising esomeprazole magnesium dihydrate, non-steroidal anti-inflammatory drug and one or more pharmaceutically acceptable excipients, wherein non-steroidal anti-inflammatory drug is present in two or more portions. More particularly, the invention relates to compositions comprising esomeprazole and naproxen and a process for preparation thereof.
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Omeprazole topics: Omeprazole, Esomeprazole, Esomeprazole Magnesium Dihydrate, Benzimidazole, Someprazole, Esomeprazole Magnesium, Omeprazole Magnesium, Polymorphic, Organic Molecules, S Omeprazole, Organic Molecule, Enantiomer, Lansoprazole
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