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Oma patents



      
           
This page is updated frequently with new Oma-related patent applications. Subscribe to the Oma RSS feed to automatically get the update: related Oma RSS feeds. RSS updates for this page: Oma RSS RSS


Method and system for permitting access to resources based on instructions of a code tagged with an identifier assigned…

Cross-domain security for data vault

Systems and methods for improving server and client performance in fingerprint acr systems

Date/App# patent app List of recent Oma-related patents
07/17/14
20140201861
 Polynucleotides and polypeptides that confer increased yield, size or biomass patent thumbnailPolynucleotides and polypeptides that confer increased yield, size or biomass
The present description relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant, including the traits of increased yield, size or biomass.. .
07/17/14
20140201822
 Method and system for permitting access to resources based on instructions of a code tagged with an identifier assigned to a domain patent thumbnailMethod and system for permitting access to resources based on instructions of a code tagged with an identifier assigned to a domain
A method including: assigning identifiers to respective domains, where each of the domains is allocated a corresponding set of resources, and where the resources in the sets of resources are accessible at respective physical addresses; storing permissions to access the physical addresses, where each of the permissions indicates which of the physical addresses one or more of the domains are permitted to access. The method also includes: assigning a code to a first domain, where the code includes instructions, and where each of the instructions includes a corresponding one of the physical addresses; tagging each of the instructions by adding the identifier assigned to the first domain to each of the instructions; and during execution of each of the instructions, comparing the identifier included in the corresponding instruction to one of the permissions; and based on the comparison, permitting access to the set of resources allocated to the first domain..
07/17/14
20140201811
 Cross-domain security for data vault patent thumbnailCross-domain security for data vault
Cross-domain security for data vault is described. At least one database is accessible from a plurality of network domains, each network domain having a domain security level.
07/17/14
20140201787
 Systems and methods for improving server and client performance in fingerprint acr systems patent thumbnailSystems and methods for improving server and client performance in fingerprint acr systems
A system and method are disclosed that improve the efficiency and performance of an automatic content recognition (acr) system. Several approaches are described that may be used alone or in combination to reduce total system computational costs related to the manner in which such an acr means takes samples, called “fingerprints,” of digital content being played by a television display device and transmits said fingerprints to a remote server to be compared to a database of fingerprints from known programming.
07/17/14
20140201774
 Systems and methods for multi-broadcast differentiation patent thumbnailSystems and methods for multi-broadcast differentiation
A system and method is disclosed for resolving false positives in a centralized, real-time automatic content recognition system that is ingesting, fingerprinting, and attempting to match for recognition purposes, multiple streams of broadcast content that are simultaneously arriving from a plurality of sources. In particular, the problem of identifying which specific broadcast of certain programming has been matched, including the episode of a series, as well as the channel, time zone and time of broadcast and whether the programing is being watched “live” as broadcast or from a dvr time-shifted source, is addressed.
07/17/14
20140201772
 Systems and methods for addressing a media database using distance associative hashing patent thumbnailSystems and methods for addressing a media database using distance associative hashing
A system, method and computer program utilize a distance associative hashing algorithmic means to provide a highly efficient means to rapidly address a large database. The indexing means can be readily subdivided into a plurality of independently-addressable segments where each such segment can address a portion of related data of the database where the sub-divided indexes of said portions reside entirely in the main memory of each of a multiplicity of server means.
07/17/14
20140201735
 Master automation service patent thumbnailMaster automation service
A method and system is provided for managing virtual machine instances (vms) and other computing and network infrastructure within a data center. A user designates a computing device or resource (whether physical or virtual) as a master automation object (e.g., a virtual machine instance may be designated as a virtual template for command replication).
07/17/14
20140201731
 Distributing and executing software code patent thumbnailDistributing and executing software code
Systems and methods for distributing and executing software code. In some embodiments, a method may include storing program instructions configured to invoke interactions with one or more of a plurality of automation devices, the plurality of automation devices divided into sets of one or more automation devices, each set of one or more automation devices associated with a respective distributed execution system (des) node.
07/17/14
20140201614
 Annotating search results with images patent thumbnailAnnotating search results with images
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for annotating search results. Images associated with a plurality of different websites are obtained and associated with respective domains of the websites.
07/17/14
20140201398
 Rate controlled first in first out (fifo) queues for clock domain crossing patent thumbnailRate controlled first in first out (fifo) queues for clock domain crossing
First in, first out (fifo) queues may be used to transfer data between a producer clock domain and a number of consumer clock domains. In one implementation, a control component for the fifo queues may include a number of counters, corresponding to each of the consumer clock domains, each of the counters maintaining a count value relating to an amount of data read by the corresponding consumer clock domain.
07/17/14
20140201325
Adaptive communication interface
Embodiments of the invention include a communication interface and protocol for allowing communication between devices, circuits, integrated circuits and similar electronic components having different communication capacities or clock domains. The interface supports communication between any components having any difference in capacity and over any distance.
07/17/14
20140201087
Touch screen having integrated epp, and input information processing method for automated teller machine using same
The present invention relates to a touch screen having an integrated epp and an input information processing method for an automated teller machine using the same, and more particularly, to a touch screen provided as user interface in an automated teller machine, wherein the touch screen and an epp module are formed integrally such that a screen displayed on the touch screen is configured to be controlled by a security cpu of the epp module integrated with the touch screen when a customer using the automated teller machine inputs information required to be encrypted, such as a password required for a financial transaction, through the touch screen of the automated teller machine during the financial transaction, thereby initially preventing the leakage of important financial information through the illegal hacking of the cpu of the automated teller machine and the like.. .
07/17/14
20140201072
Alternative billing modes for security and automation applications
A method and system facilitate the one or more operating modes for monitoring of an intelligent home system. The method and system facilitate the detection of an adverse condition in a building, the generation of an alert based on the detection of adverse condition, sending a notification to a user about the alert, asking the user how to respond to the alert via a message sent to a mobile device, and determining whether to send the alert to a central monitoring system to facilitate notification of an appropriate responder for the adverse condition.
07/17/14
20140200944
Automation of meeting scheduling and task list access permissions within a meeting series
A computer software for managing electronic meetings. The meeting management system includes a meeting series feature.
07/17/14
20140200878
Multi-domain machine translation model adaptation
A method adapted to multiple corpora includes training a statistical machine translation model which outputs a score for a candidate translation, in a target language, of a text string in a source language. The training includes learning a weight for each of a set of lexical coverage features that are aggregated in the statistical machine translation model.
07/17/14
20140200817
Seismic data processing including data-constrained surface-consistent correction
Methods and systems for constraining surface consistent amplitude corrections are described. An amplitude map generated from pre-stack or post-stack seismic data can constrain, through the bin term, the surface consistent inversion.
07/17/14
20140200808
Phase-based electromagnetic surveys for geological formations
An electromagnetic (em) data acquisition method for a geological formation may include operating em measurement devices to determine phase and amplitude data from the geological formation. The em measurement devices may include at least one first em measurement device within a borehole in the geological formation, and at least one second em measurement device at a surface of the geological formation.
07/17/14
20140200688
System and method for distributing and exchanging elements for planning and/or for operating automation operating equipment
A system and method are disclosed for distributing and exchanging elements for planning and/or operating automation operating equipment, which include at least one interface device, at least one processing device and at least one data store, wherein the interface device effects an integrated connection to at least one engineering tool and/or an integrated link to at least one engineering tool such that functionalities of the at least one interface device and of the at least one processing device can be retrieved from the respective engineering tool and carried out. The respective processing device, the respective interface device, and the respective engineering tool, elements created and/or marked by a first engineering tool can be transferred to the respective processing device and processed and/or can be made available on the at least one data store to be retrieved and/or to be transferred to and/or implemented in at least one second engineering tool..
07/17/14
20140200595
Endoscopic instrument
An endoscopic surgical instrument includes a flexible tube, a grasping and fastening end effector coupled to the distal end of the tube, and a manual actuator coupled to the proximal end of the tube. The manual actuator is coupled to the end effector by a plurality of flexible cables which extend through the tube.
07/17/14
20140200568
Method and apparatus for tissue ablation
Devices and methods for tissue ablation include injecting a conductive medium into a target tissue and then delivering an ablative agent to the conductive medium to ablate the target tissue. Optionally, the contents of the target tissue are removed using the ablation device prior to injection of the conductive medium.
07/17/14
20140200564
Devices for the treatment of biological tissue
An apparatus for treating a subcutaneous fat region is provided. The apparatus includes a housing that has a skin contacting portion defining a chamber.
07/17/14
20140200538
Wetness sensors, wetness monitoring system, and related methods
An aspect of the invention is a liquid sensor having a galvanically energizable power source capable of activating a remotely detectable signal in response to liquid. In a preferred embodiment, a liquid sensor includes a plurality of electrodes, a circuit, and a transmitter thereon.
07/17/14
20140200537
Ostomy ring
The ostomy ring offers a reliable means of attaching an ostomy or other type bag to a patient via a surgically implanted magnetically susceptible material ring and an approximately sized magnetic ring placed over the skin and bag to secure the union and prevent leakage. Even a blind person could change their own bags without fear of leakage.
07/17/14
20140200536
Leak proof equipment and method for the collection of stoma body wastes
An apparatus and system for reducing the area of exposure of intestinal effluent on a stoma wafer by 90% to 100%. The apparatus consists of substituting the pouch on a ring of a mechanically connecting ring ostomy pouch and wafer assembly by a membrane.
07/17/14
20140200440
Alignment of manipulable sensor assembly
A method for aligning a manipulable sensor assembly includes determination of a replica surface, which represents a field of view of a manipulable sensor assembly associated with an object when the object is located in a desired position and oriented at a desired orientation. Electromagnetic radiation and/or sound reflected from a surface of the region of interest is detected to provide a surface map of the region of interest, which is compared to the replica surface to determine a rotation and/or a translation for the manipulable sensor assembly to bring the surface map into alignment with the replica surface.
07/17/14
20140200406
Anti-fogging device for endoscope
Anti-fogging system for an endoscope including an endoscope having an outer housing, an imaging arrangement, and a distal window. A filter lens is located at the distal window, with the filter lens allowing a first portion of electromagnetic light to pass therethrough while absorbing a second portion of electromagnetic light in order to heat the filter lens..
07/17/14
20140200388
Concurrent stimulation of deep and superficial brain regions
Systems, devices and methods for applying therapeutic transcranial magnetic stimulation (tms) to at least one superficial cortical target brain region and at least one deep brain target so that the induced current points between the superficial cortical and deep brain targets. Systems may include two tms electromagnets configured for treating a patient by stimulating at least one deep brain region with one tms magnet at the same time that a second tms magnet stimulates at least one superficial cortical brain region.
07/17/14
20140200378
Method for producing monocyclic aromatic hydrocarbons
Method for producing monocyclic aromatic hydrocarbons includes a cracking and reforming reaction step of obtaining products containing monocyclic aromatic hydrocarbons having 6 to 8 carbon atoms and a heavy fraction having 9 or more carbon atoms by bringing the feedstock oil into contact with a catalyst for producing monocyclic aromatic hydrocarbons containing crystalline aluminosilicate to cause a reaction, a catalyst separation step of separating and removing the catalyst for producing monocyclic aromatic hydrocarbons together with tricyclic aromatic hydrocarbons contained in the products from a mixture of the products and a small amount of the catalyst for producing monocyclic aromatic hydrocarbons carried by the products, both of which are derived in the cracking and reforming reaction step, and a purification and recovery step of purifying and recovering the monocyclic aromatic hydrocarbons having 6 to 8 carbon atoms which are separated from the products formed in the cracking and reforming reaction step.. .
07/17/14
20140200377
Method for producing monocyclic aromatic hydrocarbons
The present method for producing monocyclic aromatic hydrocarbons is a method for producing monocyclic aromatic hydrocarbons having 6 to 8 carbon atoms. This method includes a cracking and reforming reaction step of bringing oil feedstock into contact with a catalyst to cause a reaction and obtain a product containing monocyclic aromatic hydrocarbons having 6 to 8 carbon atoms and a heavy fraction having 9 or more carbon atoms, a purification and recovery step of purifying and recovering the monocyclic aromatic hydrocarbons having 6 to 8 carbon atoms separated from the product formed by the cracking and reforming reaction step, and a first returning step of returning at least a portion of toluene obtained by the purification and recovery step to the cracking and reforming reaction step..
07/17/14
20140200374
Method of extracting lutein/xanthophylls from natural materials and highly purified lutein/xanthophylls obtained from the method thereof
The present invention provides the new method for extracting lutein from natural materials wherein the said method comprises of modification of natural lutein ester in the natural materials to free lutein and/or low molecular weight lutein ester, extraction of the said natural materials with supercritical fluid at the optimal conditions. The said method yields high amount of crude lutein with high purity due to the mild condition used for extraction.
07/17/14
20140200366
Method for reducing fouling during purification of (meth)acrylate esters
The present invention provides a method for reducing accumulation of solid materials when manufacturing a (meth)acrylic acid ester having low biacetyl content (less than 2 ppm) by adding an aromatic diamine under conditions which provide sufficient residence time and thorough mixing to react up to 100% by weight of the biacetyl in the crude (meth)acrylic acid ester stream, prior to separation and purification. A feedback method is also provided for reducing solids accumulation in the separation and purification equipment of such processes by measuring the biacetyl content and adjusting the aromatic diamine addition rate so that excess aromatic diamine can be minimized.
07/17/14
20140200360
Smb process
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (pufa) product from a feed mixture, which process comprises the steps of: (i) purifying the feed mixture in a first separation step in a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain an intermediate product; and (ii) purifying the intermediate product obtained in (i) in a second separation step using a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain the pufa product; wherein (a) the first and second separation steps are carried out sequentially on the same chromatography apparatus, the intermediate product being recovered between the first and second separation steps and the process conditions in the chromatography apparatus being adjusted between the first and second separation steps such that the pufa product is separated from different components of the feed mixture in each separation step; or (b) the first and second separation steps are carried out on separate first and second chromatography apparatuses respectively, the intermediate product obtained from the first separation step being introduced into the second chromatography apparatus, and the pufa product being separated from different components of the feed mixture in each separation step.. .
07/17/14
20140200354
Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof
And in which ar is an aromatic group.. .
07/17/14
20140200335
Catalytic biomass conversion
A biorefining method of processing a lignocellulosic biomass to separate lignin and hemicellulose from cellulose includes the steps of (a) reacting the biomass in an aqueous slurry having a ph less than 7, comprising a transition metal catalyst, hydrogen peroxide; and (b) separating a solid cellulose fraction from dissolved lignin and hemicellulose fractions. The method may also be used to treat cellulose and produce microcrystalline or nanocrystalline cellulose.
07/17/14
20140200331
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
The present invention provides heterodimer pairs comprising a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain. At least one of the heterodimers comprises amino acid modifications in the ch1 and/or cl domains, amino acid modifications in the vh and/or vl domains or a combination thereof.
07/17/14
20140200325
Crystalline thermoplastic polyimide resin
Wherein r1 represents a divalent group having from 6 to 22 carbon atoms containing at least one alicyclic hydrocarbon structure; r2 represents a divalent chain aliphatic group having from 5 to 12 carbon atoms; and x1 and x2 each independently represent a tetravalent group having from 6 to 22 carbon atoms containing at least one aromatic ring.. .
07/17/14
20140200323
Plastic lens
A plastic lens having excellent weather resistance, formed by polymerization of a composition containing a polyisocyanate compound having an aromatic ring and a polythiol compound is provided. The plastic lens is formed by polymerization of a composition that contains 100 parts by mass in total of (a) a polyisocyanate compound containing a polyisocyanate compound having an aromatic ring and (b) a polythiol compound, from 0.5 to 5.0 parts by mass of (c) a benzophenone compound having a hydroxyl group on at least the ortho position, and from 0.5 to 5.0 parts by mass of (d) a phenol compound..
07/17/14
20140200321
Branched conjugated diene copolymer, rubber composition and pneumatic tire
Wherein r2 represents an aromatic hydrocarbon group having 6 to 10 carbon atoms, and r5 represents a hydrogen atom or the like, and a copolymerization ratio (m) of the aromatic vinyl compound (2) is 45% by mass or more.. .
07/17/14
20140200320
Polymerizable compound, polymerizable composition, polymer, and optically anisotropic body
The present invention provides a polymerizable compound represented by the following formula (i), a polymerizable composition that includes the polymerizable compound and an initiator, a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic article that includes the polymer. The invention makes it possible to provide a polymerizable compound, a polymerizable composition, and a polymer that have a practical low melting point, exhibit an excellent solubility in a general-purpose solvent, can be produced at low cost, and may produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article.
07/17/14
20140200318
Methods for production of hydrocarbons and oxygen-containing hyrdrocarbons
Environmentally friendly, energy efficient methods for making hydrocarbons, including oxygen containing hydrocarbons, linear or branched polymers, oligomers, waxes, small hydrocarbon molecules, fuels, coatings and starting materials/reactants to be used for making other hydrocarbons. A c1 carbon source, such as coal, natural gas, petroleum or biomass (including non-food biomass), is converted to the desired hydrocarbon.
07/17/14
20140200314
Antimicrobial crosslinked polymers containing biomass derived materials
Novel, crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels and in antimicrobial compositions..
07/17/14
20140200311
(meth)allylsilane compound, silane coupling agent thereof, and functional material using the same
A (meth)allylsilane compound that a functional group of a (meth)allylsilyl group or a halogenosilyl group bonded to the (meth)allylsilyl group via a spacer group is bonded directly or through a divergent spacer group to a dehydrogenated residue of an amino group of an amino group-containing compound; a carbaminic acid ester group or an amide group derived from a dehydrogenated residue of the amino group; an aromatic compound; a polymerizable unsaturated groups; perfluoro group; a dehydrogenated residue of saccharide or a carbohydrate polyol (excluding when the divergent spacer group is an alkylene group, or an alkylene group and an arylene group); a dehydrogenated residue of an amino acid; a halogenosilyl group; or a substituted silyl group in which a halogen of the halogenosilyl group is substituted.. .
07/17/14
20140200279
Catalyst for methanation of carbon dioxide, preparation method and usage thereof
A catalyst for methanation of carbon dioxide. The catalyst is formed by mixing ash from a biomass power plant with a nickel compound and calcining the resulting mixture.
07/17/14
20140200275
Method for treating skin cancer
A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.. .
07/17/14
20140200245
Inhibitors of c-fms kinase
Wherein z, x, j, r2 and w are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of formula i, are also provided..
07/17/14
20140200234
Adjuvant chemotherapy for anaplastic gliomas
The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-pbn) in the treatment and prevention of gliomas. The 2,4-ds-pbn may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization..
07/17/14
20140200217
Smoothened antagonism for the treatment of hedgehog pathway-related disorders
The invention provides methods for modulating, e.g., antagonizing, the activity of the hedgehog signaling pathway, and for treating hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as ptch loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or gli gain-of-function by administering to a mammal combinations of smoothened inhibitors (e.g., a compound of formula i, formula ii, or formula iii, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), gli inhibitors, and/or phosphatidylinositol 3-kinase (pi3k) inhibitors..
07/17/14
20140200216
Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the pim kinases, and are useful in the treatment of diseases related to the activity of pim kinases including, e.g., cancer and other diseases..
07/17/14
20140200200
Antagonists of cb1 receptor
The invention relates to an antagonist of cb1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.. .
07/17/14
20140200192
Topoisomerase 2b as a predictor of susceptibility to anthracycline-induced cardiotoxicity
Biomarkers of anthracycline cardiotoxicity are provided. In certain aspects, methods are provided for determining whether a subject will develop cardiotoxicity upon treatment with an anthracycline, such as doxorubicin, by measuring the level of top2b expression in the subject.
07/17/14
20140200184
Chitinase-3-like protein 1 as a biomarker of recovery from kidney injury
The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/brp-39/ykl-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney..
07/17/14
20140200169
High temperature oil
The invention relates to novel high temperature oils based on aromatic esters, such as trimellitic acid esters, pryomellitic acid esters, trimesic acid esters or a mixture thereof or derivatives of phloroglucinol and a fully hydrated or a hydrated polyisobutylene or a mixture thereof.. .
07/17/14
20140200156
Genes inducing agonistic effects by anti-c-met antibody treatment and drug screening method using the genes
Biomarkers for screening drugs reducing side effects of anti-c-met antibodies and a method of screening using the biomarkers, and more particularly, biomarkers commonly enhancing or reducing gene expression and a method of screening anti-c-met antibodies having reduced side effects using the biomarkers or a method of screening drugs that reduce side effects of anti-c-met antibodies.. .
07/17/14
20140200155
Prognostic marker for endometrial carcinoma
The present invention relates to a method for diagnosing or determining the status of endometrial carcinoma in an individual afflicted with or suspected to be afflicted with endometrial carcinoma based on the phosphorylated stathmin compound whereby said stathmin is phosphorylated at position serine 38. Moreover, the present invention relates to a method for evaluating the probability of survival, the clinical outcome or the treatment course of an individual afflicted with or suspected to be afflicted with endometrial carcinoma.
07/17/14
20140200151
Biomarkers
The invention relates to a method of differential diagnosis of schizophrenia or other psychotic disorder from a further psychiatric disorder.. .
07/17/14
20140200150
Biomarkers
The invention relates to a method of differentially diagnosing schizophrenia, bipolar disorder and major depressive disorder.. .
07/17/14
20140200145
Method of metabolic evolution
The invention relates to a method for metabolic evolution of a variant of a natural small aromatic molecule product of a metabolic pathway, by somatic in vivo assembly and recombination of said metabolic pathway employing a gene mosaic of at least one gene a, which comprises a) in a single step procedure (i) transforming a cell with at least one gene a having a sequence homology of less than 99.5% to another gene to be recombined that is an integral part of the cell genome or presented in the framework of a genetic construct, (ii) recombining said genes, (iii) generating a gene mosaic of the genes at an integration site of a target genome, wherein said at least one gene a has a single flanking target sequence either at the 5′ end or 3′ end anchoring to the 5′ or 3′ end of said integration site, (iv) recombining eventual further genes of said metabolic pathway, and b) selecting clones comprising said gene mosaic and said eventual further genes capable of expressing said variant, methods of preparing a library of cells producing variants of natural small aromatic molecule products of a metabolic pathway, the libraries so produced and used to prepare said variants.. .


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