Second generation tape
Karen Pilney Montpetit
Eva S. Snitkin
U.S. Patent Documents
6. Scales JT. Materials for hernia repair. Proc R. Sac...
Synthesis of labile base protected - modified deoxy & modified ribo nucleosides, corresponding phosphoramidites and supports and their use in high purity oligonucleotide synthesis
This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base, nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-acetyl protected guanine as nucleoside base protecting group, which is significantly faster base labile...
Method of synthesizing single-stranded cdna, method of preparing microarray sample, and method of detecting nucleic acid
In order to provide a method of amplifying nucleic acid which can produce a nearly constant amount of amplified products despite the amount of RNA to be used as a template, the primer is used at a final concentration of 500 pM to 500 nM in a reaction which synthesizes a...
Method for producing organo-oligo silsesquioxanes
Silsesquisiloxanes are produced in high yield and purity in a minimal number of process steps by reacting quaternary ammonium silicates with disiloxanes in a precipitant liquid which causes the silsesquisiloxane product to be precipitated in high purity....
Rapid display method in translational synthesis of peptide
Provided are linkers suitable for preparing a conjugate of a nucleic acid and a peptide as a translation product thereof in a reconstituted cell-free translation system in genotype-phenotype mapping (display methods), said linkers comprising a single-stranded structure region having a side chain base pairing with the base at the 3′-end of...
Solid surface reservoirs
An apparatus for forming a surface reservoir to hold a sample for a desirable period of time is described. The apparatus contains a platform, a solid surface disposed onto the platform, and an assembly of a bottomless vessel mounted on the solid surface. Also described is an apparatus that forms an...
Systems and methods for validating and customizing oligonucleotides sequences
A system and method is provided to customize and validate an oligonucleotide plate and/or tube design. A graphical user interface enables a user to submit oligo design data in a series of steps. One or more rules are used to validate the oligo plate design data as it is submitted. The...
Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
Compositions and methods for down modulating target gene expression with RNA interference, as well as methods for administering said compositions are disclosed. The method comprises administering a first strand to a cell, incubating the cell for a time period suitable for uptake of the first oligo prior to administering a second...
Structure, synthesis, and applications for oligo phenylene ethynylenes (opes)
The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and anti-fungal activity....
Polymeric coupling agents and pharmaceutically-active polymers made therefrom
(iv) n is selected from 2-50. The compounds are useful as biomaterials, particularly, providing antibacterial activity in vivo. Also provided are biological coupling agents useful as intermediates in the preparation of the pharmaceutically-active polymeric compounds.
(iii) m is 1-40; and