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Structure, synthesis, and applications for oligo phenylene ethynylenes
Novel compounds generally referred to herein as cationic oligomeric phenylene ethynylenes (OPEs), methods of synthesizing OPEs and various uses for the OPEs are described. The compounds can be synthesized in both symmetrical (S-OPE) and non-symmetrical (N-OPE) forms. Suitable uses include sensor and biocidal applications. Reusable structures incorporating the OPEs that are...

Compositions and methods for treating hypophosphatasia
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which...

Method for producing and stabilizing oligoaminosilanes
The invention relates to a method for producing oligoaminosilanes of the general formula (I) SinY2n+2, wherein oligohalosilanes of the general formula (II) SinX2n+2 are reacted with primary amines of the general formula (III) R—NH2 in hydrocarbons as solvents, wherein X is selected from among chlorine, bromine, and iodine, Y is a...

Polymeric hair dyes
Polymeric dye comprising oligo and polypeptides selected from natural or synthetic aminoacids bearing at least one covalently bounded cationic dye. Very good dyeing results on human hair are obtained with these dyes....

Rapid oligo probes
Disclosed are methods, rapid probes, and kits for general purpose nucleic acid detection....

Second generation tape
Jan Claren Mar. 2008 7,347,813 B2 Karen Pilney Montpetit Jul. 2008 7,393,320 B2 Eva S. Snitkin Apr. 2006 7,025,063 B2 Patrice Suslian Oct. 2003 6,638,211 B2 Jorn Lehe Aug. 2001 6,273,852 B1 U.S. Patent Documents 6. Scales JT. Materials for hernia repair. Proc R. Sac...

Synthesis of labile base protected - modified deoxy & modified ribo nucleosides, corresponding phosphoramidites and supports and their use in high purity oligonucleotide synthesis
This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base, nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-acetyl protected guanine as nucleoside base protecting group, which is significantly faster base labile...

Method of synthesizing single-stranded cdna, method of preparing microarray sample, and method of detecting nucleic acid
In order to provide a method of amplifying nucleic acid which can produce a nearly constant amount of amplified products despite the amount of RNA to be used as a template, the primer is used at a final concentration of 500 pM to 500 nM in a reaction which synthesizes a...

Method for producing organo-oligo silsesquioxanes
Silsesquisiloxanes are produced in high yield and purity in a minimal number of process steps by reacting quaternary ammonium silicates with disiloxanes in a precipitant liquid which causes the silsesquisiloxane product to be precipitated in high purity....

Rapid display method in translational synthesis of peptide
Provided are linkers suitable for preparing a conjugate of a nucleic acid and a peptide as a translation product thereof in a reconstituted cell-free translation system in genotype-phenotype mapping (display methods), said linkers comprising a single-stranded structure region having a side chain base pairing with the base at the 3′-end of...

Solid surface reservoirs
An apparatus for forming a surface reservoir to hold a sample for a desirable period of time is described. The apparatus contains a platform, a solid surface disposed onto the platform, and an assembly of a bottomless vessel mounted on the solid surface. Also described is an apparatus that forms an...

Systems and methods for validating and customizing oligonucleotides sequences
A system and method is provided to customize and validate an oligonucleotide plate and/or tube design. A graphical user interface enables a user to submit oligo design data in a series of steps. One or more rules are used to validate the oligo plate design data as it is submitted. The...

Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
Compositions and methods for down modulating target gene expression with RNA interference, as well as methods for administering said compositions are disclosed. The method comprises administering a first strand to a cell, incubating the cell for a time period suitable for uptake of the first oligo prior to administering a second...

Structure, synthesis, and applications for oligo phenylene ethynylenes (opes)
The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and anti-fungal activity....

Polymeric coupling agents and pharmaceutically-active polymers made therefrom
(iv) n is selected from 2-50. The compounds are useful as biomaterials, particularly, providing antibacterial activity in vivo. Also provided are biological coupling agents useful as intermediates in the preparation of the pharmaceutically-active polymeric compounds. (iii) m is 1-40; and ...

Dithiolane based thiol modifier for labeling and stronger immobilization of bio-molecules on solid surfaces
The thiol modified oligonucleotides have vast number of applications in the field of nucleic acid chemistry. The conjugates generated by mono thiol groups are unstable at higher temperature, in high salt concentration buffers and in presence other thiols. There is strong need to develop a novel thiol modifier probes that can...

Polyether polyol resins compositions
The invention relates to compositions of polyether polyol resins (hydroxyfunctional oligo or poly ether) comprising a mixture of α,α-branched alkane carboxylic glycidyl esters derived from butene oligomers characterized in that the sum of the concentration of the blocked and of the highly branched isomers is maximum 55%, preferably below 40%, and...

Polyether polyol resins compositions
The invention relates to compositions of polyether polyol resins (hydroxyfunctional oligo or poly ether) comprising a mixture of α,α-branched alkane carboxylic glycidyl esters derived from butene oligomers characterized in that the sum of the concentration of the blocked and of the highly branched isomers is at least 50%, preferably above 60%...

Preparation of oligo conjugates
Conjugated molecules are prepared that comprise a predetermined number of oligo conjugation components. The conjugated molecules also may comprise one or more detectable labels. Preparation of these molecules can be implemented according to an asymmetric or a symmetric conjugation strategy....

Preparation of oligo conjugates
Conjugated molecules are prepared that comprise a predetermined number of oligo conjugation components. The conjugated molecules also may comprise one or more detectable labels. Preparation of these molecules can be implemented according to an asymmetric or a symmetric conjugation strategy....

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