|| List of recent Ocular-related patents
|Adjustable toric intraocular lens|
An adjustable astigmatism-reducing intraocular lens includes a toric optic with a long axis. The optic is rotationally coupled to haptics, and a plurality of struts extend between the optic and the haptics.
|Plunger tip coupling device for intraocular lens injector|
The present disclosure is directed to devices, systems, and methods directed to mounting a plunger tip to a plunger of an iol injection device. A plunger tip wrench that is operable to releasably retain a plunger tip may be coupled to a holder extending from an end of the iol injection device to align the plunger tip with the plunger of the iol injection device.
|Pre-loaded iol insertion system|
A system for easily transferring an intraocular lens (iol) from an inserter into a patient's eye. The system includes an inserter handpiece with a holding station for receiving or storing an iol.
|Robust laser cutting methods for ophthalmic surgery|
A method and apparatus for performing ophthalmic laser surgery using a pulsed laser beam is provided. The method includes establishing an initial cutting pattern comprising a plurality of original photodisruption points, establishing an enhanced cutting pattern comprising a plurality of enhanced photodisruption points selected to decrease potential adverse effects due to patient movement and having increased density over a fixed area as compared with the plurality of original photodisruption points, and performing an ocular surgical procedure according to the enhanced cutting pattern.
|Rnai-mediated inhibition of select receptor tyrosine kinases for treatment of pathologic ocular neovascularization-related conditions|
Rna interference is provided for inhibiton of expression of select receptor tyrosine kinase (rtk) targets in ocular neovascularization-related conditions, including those cellular changes resulting from the signal transduction activity of the select rtk targets that lead directly or indirectly to ocular nv, abnormal angiogenesis, retinal vascular permeability, retinal edema, diabetic retinopathy particularly proliferative diabetic retinopathy, diabetic macular edema, exudative age-related macular degeneration, sequela associated with retinal ischemia, and posterior segment neovascularization.. .
|Cyclosporin derivatives for treating ocular and dermal diseases and conditions|
—n═c(r8)(nr9r10), i.e. Amidines wherein r3-r10 is h, alk, ar or (ch2)nar wherein ar is an aryl group and n is an integer of from 1 to 13 or r3 and r4 or r4 and r5 or r5 and r7 or r3 and r7, or r9 and r10, together may be —ch2—ch2— or —ch2—ch2—ch2— and r2 is selected from the group consisting of hydroxyl, lower alkyl and hydroxyl-substituted lower alkyl and r2 is selected from the group consisting of hydroxy and lower alkyl..
|Sustained release intraocular implants and methods for treating ocular neuropathies|
Biocompatible intraocular implants include a beta adrenergic receptor antagonist and a polymer associated with the beta adrenergic receptor antagonist to facilitate release of the beta adrenergic receptor antagonist into an eye for an extended period of time. The beta adrenergic receptor antagonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers.
|Intraocular lens insertion device|
There is provided an intraocular lens insertion device capable of appropriately regulating the motion of a rear supporting portion during a process of moving an intraocular lens, and reducing the possibility of reoperation being required after the intraocular lens is inserted into an eye. An intraocular lens insertion device 1 comprises a main body 2, and a slider 3 and a plunger 4 that are attached to the main body 2.
|System and method of performing femtosecond laser accomodative capsulotomy|
Disclosed is a system and method for making a first incision in an anterior capsule of a capsular bag, the first incision being less than or equal to approximately 3.5 mm in diameter and making a second incision in the anterior capsule, the second incision being less than or equal to approximately 3.0 mm in diameter. The first incision and the second incision are positioned off-center from a center portion of the anterior capsule.
|Auto-regulation system for intraocular pressure|
A device and system for controlling pressure via fluid exchange in the body is presented. The device and system may be used to control intraocular eye pressure.
|Silk compositions and methods of using same|
The present invention provides for silk-derived compositions for treating a wide variety of ocular conditions. The composition is produced by processing the silk cocoon into a water-based solution (i.e., a dissolved silk), which is then cast into a film.
|Anti-pdgfr-beta antibodies and uses thereof|
The present invention provides antibodies that bind to platelet derived growth factor receptor beta (pdgfr-beta) and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human pdgfr-beta with high affinity.
|Method for the pre-operative selection of an intraocular lens to be implanted in an eye|
A method for the preoperative selection of an intraocular lens to optimise the results of refractive surgery on the eye. On the basis of an eye model comprising the individual biometric parameters of the eye, potentially suitable iols are selected on the basis of their optical parameters such as optical power, asphericity and toricity, and the residual refraction of potentially suitable iols is calculated using ray tracing.
|Vision measurement and training system and method of operation thereof|
A binocular viewer, a method of measuring and training vision that uses a binocular viewer and a vision measurement and training system that employs a computer to control the binocular viewer. In one embodiment, the binocular viewer has left and right display elements and comprises: (1) a variable focal depth optical subsystem located in an optical path between the display elements and a user when the user uses the binocular viewer and (2) a control input coupled to the left and right display elements and the variable focal depth optical subsystem and configured to receive control signals operable to place images on the left and right display elements and vary a focal depth of the variable focal depth optical subsystem.
|Retinal prosthesis techniques|
Apparatus for use with an external non-visible light source is provided. The apparatus comprises an intraocular device configured for implantation in a human eye, and comprising an energy receiver.
|Back loaded iol insertion cartridge|
A rear-loaded injector cartridge for an intraocular lens (iol) having a proximal opening that provides a haptic slot. The haptic slot receives a leading haptic of an iol loaded therein, and temporarily retains the leading haptic while the optic of the iol is inserted into a holding area of the cartridge.
|Intraocular lens insertion device|
A cartridge for an intraocular lens insertion device is disclosed. An example cartridge may include an intraocular lens insertion cartridge body having a distal end and a proximal end and configured to receive an intraocular lens for insertion into a patient's eye through an incision; the intraocular lens insertion cartridge body having an inner surface comprising at least one polymeric material having a hardness greater than about 50d and an elongation at break greater than about 150%; the inner surface of the intraocular lens insertion cartridge body defining an at least partially tapering insertion pathway disposed within the intraocular lens insertion cartridge body and extending from the proximal end to the distal end of the intraocular lens insertion cartridge body..
|Ocular pressure regulation|
Disclosed are devices and methods of treating an ocular disorder including forming a self-sealing incision in a cornea into an anterior chamber of an eye; introducing through the incision a fluid drainage tube having a distal end, a proximal end and a longitudinal, internal lumen extending through the fluid drainage tube, wherein at least the proximal end passes through the anterior chamber; and implanting the distal end of the fluid drainage tube in fluid communication with the suprachoroidal space such that the proximal end of the fluid drainage tube remains in fluid communication with the anterior chamber.. .
|Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof|
The present invention provides tromethamine salt of 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” the invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension..
|Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof|
The invention provides new crystalline forms of 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid. This compound is commonly referred to as “bimatoprost acid.” the novel crystalline forms are designated forms i, ii, and iii.
The present invention relates a composition comprising diclofenac and salts thereof wherein diclofenac or its salts are present in an amount of 25-200 mg. The composition is suitable for the parenteral administration through intramuscular, intravenous route; also for oral, dermal, subcutaneous, cutaneous, nasal, ocular drops, as rectal suppository, vaginal pessaries, intra-articular, and otic delivery.
|Dual mechanism inhibitors for the treatment of disease|
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (mat) act to improve the disease state or condition. Further provided are compositions comprising the compounds.
|Compounds and methods of use thereof for treating neurodegenerative disorders|
Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.. .
|Ocular drug delivery devices|
A method of forming an ocular delivery device includes exposing a solid, shaped cellulose polymer to a solution including an active pharmaceutical ingredient (api) and a solvent capable of solubilizing the api, wherein the polymer absorbs at least a portion of the solution, including the api and solvent. The method may further include removing at least a portion of the absorbed solvent from the polymer by allowing the absorbed solvent to evaporate from the polymer or by drying the polymer.
The present invention relates to compositions and methods for eye and contact lens care. More particularly, the invention relates to ophthalmic compositions which contain at least one bioflavonoid component for ocular care, preserving ophthalmic solutions and/or disinfecting contact lenses..
|Compositions and methods for long acting molecules|
The invention relates, in part, to compositions and methods that utilize a peptide tag that binds to hemagglutanin (ha). The ha tag can be linked to a molecule such as a protein or nucleic acid which, when administered to the eye, results in an increase in ocular half-life and/or mean residence time, and or a decrease in ocular clearance of the protein or nucleic acid.
|Compositions and methods for treating ocular diseases and conditions|
The present invention relates to compositions and methods for prevention and treatment of ocular diseases and conditions, particularly glaucoma and ocular hypertension. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1-phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted.
|Optical microscope apparatus|
An optical microscope system and method having a birefringent material for decomposing light from a light source into ordinary and extraordinary waves, a first prism for directing the decomposed light sequentially through a specimen and an objective along a light path and a second prism positioned in the light path of the decomposed light, said second prism positioned subsequent the objective and prior to an ocular assembly.. .
|Intraocular lens or lens system to provide monofocal vision at multiple pre-defined focal points|
An accommodative intraocular lens is described that provides monofocal vision at multiple pre-defined focal points during accommodation. The intraocular lens includes a lens element having a series of stacked optics that can be formed utilizing multiple different materials, each of which can have a different stiffness.
|Accommodating intraocular lens providing progressive power change|
An accommodating intraocular lens for providing a range of accommodative vision includes a deformable optic. The deformable optic includes a plurality of layers that have a progressively increasing hardness and/or refractive index characteristic from the outermost layer to the innermost layer to provide a range of accommodative power..
|Edge design for reducing unwanted photic effects in intraocular lenses|
An intraocular lens (iol) has an optic, a peripheral rim, and a reduced thickness region connecting the optic to the peripheral rim. The peripheral rim has a continuously curving outer edge that it does not include any tangents parallel to the optical axis either along its length or at the intersection of the outer edge with the anterior or posterior surfaces of the iol..
|Accommodative intraocular lens|
An accommodating intraocular lens implant includes an anterior floating lens unit, a posterior lens unit, an anterior lens link, a posterior lens link, and an anterior rim link, which comprises an anterior rim jointed element. An anterior rim complex is disposed such that the anterior floating lens unit is movable toward and away from the anterior rim complex, in an anterior-posterior direction.
|Accommodating intraocular lens|
A dynamic accommodative intraocular lens is provided in which a central lens portion of the intraocular lens undergoes dynamic change in curvature to adjust focus from distant objects to those nearby in response to natural accommodative actions of the patient's eye. The intraocular lens utilizes fluid movement from flexible fluid reservoirs defined along or adjacent haptic elements of the intraocular lens, which are engaged and compressed by the accommodating movements of the ciliary body of the patient's eye to cause expansion and flattening of the intraocular lens to adjust the optic power of the lens..
|Curvature changing accommodative intraocular lens|
A curvature changing accommodative intraocular lens is provided in which the anterior surface of the intraocular lens undergoes dynamic change in curvature to focus light from distant objects to those nearby. The lens utilizes fluid movement from bladders defined as junctions between haptic elements and lens element or bladders positioned between the haptic elements and lens element periphery to change the curvature..
|Curvature changing accommodative intraocular lens|
A curvature changing accommodative intraocular lens for implantation into the eye of a patient includes a lens body having a base lens which has a base lens power, and a haptic structure including haptic elements projecting from the base lens. An actuator is placed into engagement with the lens body, and includes actuator haptic elements.
|Accommodating intraocular lens|
An accommodating intraocular lens (iol) comprises an anterior lens, a posterior surface and an articulating member joining the anterior lens and the posterior surface to define an enclosed cavity. The articulating member comprises anterior and posterior arms coupling the anterior lens and the posterior surface, respectively.
|Intraocular lens insertion device|
An instrument for inserting an intraocular lens capable of securely and safely pushing out the lens by a simple structure. An instrument (1) for inserting comprises: a body (3) having a lens placement part (8) on which the lens (2) with a pair of loop parts (2b) at its optic part (2a) is installed, a transition part (12) deforming the lens (2), and a nozzle part (11) discharging the lens (2); and a lens push-out mechanism (4) pushing out the lens (2) placed on the lens placement part (8).
|Intraocular lens insertion device|
An intraocular insertion device (1) capable of safely performing discharge operation of a lens (2) by a simpler construction. The intraocular lens insertion device (1) has a body (5) provided with a lens placement section (3) where the lens (2) is placed and a tube section (4) for inserting the lens (2) into an eye and has a plunger (6) for discharging the lens (2) placed on the lens placement section (3).
|Lacrimal implants and related methods|
Lacrimal implants for treating diseases or disorders are disclosed. More particularly, lacrimal implants, methods of making such implants, and methods of treating ocular, respiration, inner ear or other diseases or disorders using such implants are disclosed..
|Intraocular shunt placement|
Methods are provided for using an intraocular shunt deployment device to deploy an intraocular shunt from the device and into an eye.. .
|Method and apparatus for monitoring eye tremor|
An apparatus consistent with the present invention comprises a sensor for receiving a signal representing eye tremor and a processor for monitoring eye tremor while receiving the signal. A method consistent with the present invention includes receiving a signal representing eye tremor, comparing the received signal representing eye tremor to at least one reference value; and classifying a patient's brain stem function using the comparison of the received signal representing eye tremor to at least one reference value.
|Apparatus and method for detecting amyloid in a retina in a diagnosis, advancement, and prognosing of alzheimer's disease, traumatic brain injury, macular degeneration and a plurality of neurodegenerative dissorders, and ocular diseases|
The present invention is an apparatus and method to produce an image of an eye of a patient that includes an optical head that includes imaging optics, illumination source optics and a camera housing with a perimeter that houses the video camera optics and the illumination source optics, a slit lamp chinrest and joystick assembly that includes an adjustable head support, a movable base, a joystick that adjusts a position of the camera housing relative to the head support and the housing support that mounts the video camera, a rubber eyecup that provides an interface between the camera housing and the patient's eye that protrudes outward from the perimeter and a computer system that analyzes images and data for the presence of amyloid in a retina, and other deposits and provides a diagnosis of macular degeneration, alzheimer's disease, traumatic brain injury, multiple concussive injury, neurodegenerative and other ocular disorders.. .