 Patent Application Title |
Patent App Num. |
Date |
| Treatment pad for treating obstructive sleep apnea syndrome | 20130098369 | 20130425 |
 A treatment pad includes a base member, at least one treatment layer, a plurality of neck supporting members, and an adhesive layer. The treatment layer is peripherally extended from the base member, wherein the treatment layer has a mid portion and two side portions. The neck supporting members are longitudinally extended along the side portions of the treatment layer respectively, wherein each of the neck supporting members has a height gradually increasing from the an inner side edge of the corresponding side portion of the treatment layer to an outer side edge of the corresponding side portion of the treatment layer to define an inclined supporting surface of the corresponding neck supporting member. The adhesive layer is provided on the treatment layer and the neck supporting... |
| Devices and methods for sleep apnea treatment | 20130085546 | 20130404 |
 Devices and methods for improving the coupling between the soft palate and the genioglossus. This may be accomplished, for example, but shortening or stiffening the palatoglossal arch. Improved coupling between the soft palate and the genioglossus may be beneficial to a patient suffering from obstructive sleep apnea (OSA) as a stand-alone procedure, or in combination procedures and devices that cause anterior displacement of the tongue such as hypoglossal nerve stimulation, genioglossus advancement surgery, mandibular advancement surgery, mandibular advancement (oral) appliances, etc.
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| Sling-based treatment of obstructive sleep apnea | 20130056009 | 20130307 |
 Slings, kits, and methods useful in the treatment of Obstructive Sleep Apnea (OSA) are described. An exemplary sling comprises a main body extending along a lengthwise axis and having first and second opposing ends, first and second opposing sides, and first and second opposing surfaces. Each end defines an end loop that defines a passageway extending through the main body. An exemplary method of treatment comprises creating two openings in the mandible of a patient; creating two longitudinal tunnels in the tongue of the patient; creating a transverse tunnel in the tongue of the patient; advancing a sling through the transverse tunnel; pulling each end of the sling through one of the longitudinal tunnels and through one of the openings in the mandible; pulling the tongue... |
| Devices for treating obstructive sleep apnea and/or snoring | 20130014766 | 20130117 |
 A garment for the treatment of sleep apnea and/or snoring includes a member for attachment to an individual afflicted with sleep apnea and an elongate, position control member at the rear of the garment and extending outwardly therefrom. The elongate member is a continuous member having transversely spaced-apart side surfaces, and the side surfaces are joined to an outer wall of the position control member at elongate side edges. The side surfaces and/or side edges are located to engage a mattress or other sleeping surface when an individual wearing the garment is sleeping in a lateral position to aid in supporting the individual in a lateral position.
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| Method and apparatus for providing positive airway pressure to a patient | 20120325212 | 20121227 |
 Methods and apparatus for treatment of medical disorders such as obstructive sleep apnea and congestive heart failure are disclosed. A method involves delivering pressurized air, oxygen or other breathing gas to a patient during a respiratory cycle, where pressure of the air is decreased according to an expiratory unloading factor during expiration. The timing and magnitude of the pressure change may be fully automated and responsive to feedback from a motor load sensor, optionally in combination with a pressure sensor.
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| Centralized hospital monitoring system for automatically detecting upper airway instability and for preventing and aborting adverse drug reactions | 20120330118 | 20121227 |
| A system and method for the automatic diagnosis of obstructive sleep apnea in a centralized hospital critical care monitoring system for the monitoring of a plurality of patients in at least one of a critical care, step down, and cardiac ward by telemetry. The system includes a central processor having a display, and a plurality of telemetry units for mounting with patients, each of the telemetry units has a plurality of sensors for connection with each patient, the telemetry unit is capable of the transmission of multiple signals derived from the sensors to the central processor, in one preferred embodiment the method comprising steps of programming the system to analyze the signals and to automatically identify the presence and severity of obstructive sleep apnea and to... |
| Method of performing multiple oral and nasal surgical procedures | 20120310274 | 20121206 |
| The method of performing multiple oral and nasal surgical procedures may be applied to various different but related medical procedures, but is particularly well adapted for the performance of multiple operations for correcting various ear, nose, and throat conditions that cause obstructive sleep apnea (OSA) in the patient. The method allows the surgeon to perform multiple operating procedures in the nose, mouth, and/or throat in a single operating session, due to the use of hemostatic sheet and gel treatments in lieu of suturing and post-operative nasal hemostatic packs that preclude nasal breathing. A tracheal breathing tube is placed in the patient during the operation, leaving the surgeon free to perform multiple operations in the nose, mouth, and/or throat with hemostatic packs being placed immediately following each... |
| Patient ventilation device and components thereof | 20120285454 | 20121115 |
| The invention relates to a patient ventilation or breathing device and components therefore for use in all forms of respiratory apparatus ventilation systems including invasive and non-invasive ventilation, positive airway pressure therapy, Continuous Positive Airway Pressure (CPAP), and particularly Bi-Level therapy and treatment for sleep disordered breathing (SDB) conditions such as Obstructive Sleep Apnea (OSA), and for various other respiratory disorders and diseases. The invention particularly relates to a blower, to a blade, to a gasket, to a cable, to an impeller, to a gas inlet and inlet member, to an improved air path or fluid flow path and components thereof, and/or to a modular ventilation or breathing device as referred to above and particularly incorporating one or more of the other aspects of the invention.
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| Respiration monitoring for heart failure using implantable device | 20120283527 | 20121108 |
| An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central... |
| Systems and methods for sleep apnea detection from breathing sounds | 20120271199 | 20121025 |
| A method is disclosed of detecting obstructive sleep apnea in subject. The method includes the steps of placing a head of an electronic stethoscope at the subject's suprasternal notch, providing an electrical signal representative of the sounds detected by the head of the electronic stethoscope within a frequency range, determining an obstructive sleep apnea index based on a ratio of the amount of the electrical signal that is associated with a frequency below a cut-off frequency with respect to a total amount of energy associated with the entire frequency range, and identifying the subject as having obstructive sleep apnea if the obstructive sleep apnea index is above a window maximum or below a window minimum.
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| Devise for snoring and obstructive sleep apnea treatment | 20120255561 | 20121011 |
| A device for snoring and obstructive sleep apnea treatment has an oral elastic glove portion adapted to removably cover a free moving portion of a user's tongue. Three vacuum suction cups are used to attach the device to the hard palate and the dorsal and ventral surfaces of the tongue in order to hold the device in place without allowing the tongue to move backwards. A vacuum creating cannula and a syringe attached to a tip of the device to create a vacuum once the device in positioned in the user's mouth. In addition, a balloon is provided to prevent soft palate vibrations. A skin attachment pad is removably attached to the user's face close to the mouth and holds the end of a string provided... |
| Energy-harvesting respiratory method and device | 20120234323 | 20120920 |
| This invention is a method, device, and system to provide respiratory assistance to people with Obstructive Sleep Apnea (OSA), or other respiratory conditions, comprising harvesting and storing energy from gas outflow during exhalation and using that stored energy to increase gas inflow during inhalation. In an example, this invention may provide Positive End-Expiratory Pressure (PEEP) or Continuous positive Airway Pressure (CPAP). This invention can be embodied in a self-contained energy-harvesting positive airway pressure mask, nasal inserts, or mouth appliance. This invention offers a combination of the following five benefits for Obstructive Sleep Apnea (OSA) treatment: minimally-invasive; energy self-sufficient; freedom of movement; hypercapnia avoidance; and adjustable energy harvesting over multiple respiratory cycles.
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| Snoring and obstructive sleep apnea prevention and treatment device | 20120234331 | 20120920 |
| The present invention is a safe, inexpensive, easy to use and effective anti-snoring and anti-sleep apnea treatment device. The device has a vertical and horizontal bar. The horizontal bar is placed inside the mouth, behind or between the molar teeth with palatine and tongue shelves to prevent snoring and movement of the tongue backwards. The device is tethered to the hard palate by vacuum cups to prevent the movement of the tongue backwards during sleep to prevent sleep apnea. The proximal end of the vertical bar is anchored to string at the distal end with hook and loop fabric closure adhesive attachment and to the lips outside the mouth to prevent the accidental swallowing and aspiration of the device; and at the same time holds the... |
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| Snoring and obstructive sleep apnea prevention and treatment device | 20120234332 | 20120920 |
| A anti-snoring and anti-obstructive sleep apnea apparatus has a plate or metal frame tongue shelf splint to prevent the flaccid tongue falling back, a palate shelf splint projection to elevate the soft palate and prevents its vibration, incisors teeth receptacles or pockets sockets for jaw displacer to hold the mandible moved forwards, and to prevent it falling back held between the bite block, catheter-tubing to administer oxygen supplementation from the external source which reduces air turbulence and promotes nasal breathing, a submental suprahyoid muscle stimulator placed below the tongue, and above the mucous membrane. An injection port is provided to administer any therapeutic agents and local anesthetics to reduce the sensitivity of the tongue and oral cavity mucus membrane lining to the foreign objects. This device... |
| Mask assembly | 20120216819 | 20120830 |
| A respiratory mask for treatment of obstructive sleep apnea using gas pressurized in the range of about 4 to 20 cm H2O, the mask comprising a mask body, a flexible inlet tube having a first end coupled to the mask body and second end adapted to extend upwardly over a patient's head in use for connection to an air delivery tube. a cushion supported by the mask body, a harness to support the mask body and cushion on the patient's head, an elongated clip extending from each lateral side of the mask body, each said clip having a slot to receive an engaging strap of the harness, a ball and socket joint including a ball portion and a socket, wherein the ball portion comprises a part-spherical... |
| Method and apparatus to detect and monitor the frequency of obstructive sleep apnea | 20120209127 | 20120816 |
| The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus measures sinus tachycardia and a change in the atrial-ventricular conduction, and includes a controller for receiving the measurement of the sinus tachycardia and the change in the atrial-ventricular conduction to detect obstructive sleep apnea based upon the sinus tachycardia and the change in the atrial-ventricular conduction.
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| Partially erodable systems for treatment of obstructive sleep apnea | 20120197070 | 20120802 |
| The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material. The deformable portion of the device has a preferred shape that corresponds to the desired final shape of the device once placed in an airway. In making a transplant-ready device, however, the deformable portion is placed into a deformed shape and constrained in that shape by the bioerodible material. After implantation, the device gradually assumes the preferred shape as the constraining bioerodible material erodes. As the device gradually reforms toward the preferred shape, it reforms the tissue into the therapeutically desirable... |
| Methods for treating obstructive sleep apnea | 20120197235 | 20120802 |
| The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.
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| Screening devices and methods for obstructive sleep apnea therapy | 20120197340 | 20120802 |
| Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position. An adequate response of the upper airway during the tongue protrusion maneuver is indicative of likely therapeutic success with hypoglossal nerve stimulation, and may be used for making clinical decisions. The principles of the present invention may be applied to other therapeutic interventions for OSA involving the upper airway.
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| Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues | 20120197361 | 20120802 |
| Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.
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| Device and method for correcting obstructive sleep apnea | 20120184799 | 20120719 |
| An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone, where the ferric element is disposed to face along a treatment vector from the hyoid bone, and the treatment vector is oriented relative to a sagittal plane of a human. The orthotic obstructive sleep apnea treatment device further includes an external orthotic neck device having a contoured housing with a shape disposed to conform about a neck of the human subject, where the housing includes a force delivery element disposed at an exterior-front neck region of the human subject and is disposed to provide an attractive force to the ferric element along the treatment vector. A force sensor is disposed... |
| Tongue advancement device for reducing obstructive sleep apnea condition | 20120160249 | 20120628 |
| A tongue advancement device according to various embodiments can include at least one first magnet provided in a mouthpiece and a tongue implantation device. The at least one first magnet comprises a substantially flat surface that aligns with a peripheral edge of the mouthpiece, such that the at least one first magnet does not extend from the mouthpiece. The tongue implantation device, such as a tongue piercing, includes a second magnet that magnetically interacts with the at least one first magnet to retain the tongue of the user in a forward position when the mouthpiece is worn. The device can also include a tongue cover consisting of a flexible tubular body having an opened end, a closed end and a magnet attached to the closed end.... |
| Pre-emptive fluid shifts to treat osa | 20120157900 | 20120621 |
| A method of treating obstructive sleep apnea comprising reducing an effective amount of extracellular fluid of a patient suffering from obstructive sleep apnea.
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| Method and apparatus for treating airway obstruction | 20120136440 | 20120531 |
| Methods and Devices for treating airway openings and breathing disorders including obstructive sleep apnea are disclosed. Structures and methods disclosed herein maintain and preserve airway openings against posterior collapse of the tongue.
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| Nasally inserted airway opening device for obstructive sleep apnea treatment | 20120118297 | 20120517 |
| A nasally inserted airway opening device with inflatable cuff is provided to treat obstructive sleep apnea. The airway opening device includes a hollow flexible tube extending between a proximal end and a distal end, and an inflatable cuff attached to the tube at or near the distal end. The inflatable cuff may be inflated and deflated via the tube. The inflatable cuff defines an interior through hole extending along the length thereof. When deflated, the inflatable cuff may be packed closely to the tube and may be inserted or removed through a nostril of a user. When inserted through the user's nostril and positioned in the user's oropharynx or naso-oropharynx and inflated, the inflatable cuff prevents soft tissue in the user's naso-oropharynx from collapsing toward the... |
| Devices for diagnosing sleep apnea or other conditions and related systems and methods | 20120123286 | 20120517 |
| A system includes a sensor device having a body configured to be inserted into an airway of a patient and one or more sensors mounted in or on the body. The one or more sensors are configured to collect sensor data associated with the airway of the patient. The system also includes a signal analyzer configured to analyze the sensor data. The one or more sensors could include one or more microphones. The signal analyzer could identify volume and/or pitch characteristics of the sensor data, perform pattern recognition to identify one or more patterns using the volume and/or pitch characteristics, and use the one or more patterns to identify a type, a location, and/or a degree of airway obstruction. This could be done, for instance, to... |
| Grooved electrode and wireless microtransponder system | 20120065701 | 20120315 |
| A grooved electrode adapted for interfacing cellular matter is provided. The grooved electrode includes grooves adapted for electrically interfacing the grooved electrode with cellular matter growing along the body of the grooved electrode. Further, the grooved electrode includes a wireless transponder adapted to electrically interface with cellular matter and to relay such interactions via RF signals. The RF signals received by the wireless transponder are modulated in response to electrical signals generated by the cellular matter, which are detected by the transponder. The grooved electrode may be implanted within peripheral nerves for treating various neurological conditions, which may include nerve rehabilitation and prosthetic actuation, severe pain, obstructive sleep apnea and so forth.
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| Novel use of fibrates | 20120035197 | 20120209 |
| The present invention, which is applicable in the pharmaceutical industry, relates to the use of fibrates, in particular fenofibrate, especially in the form of a solid oral composition, for the manufacture of a drug for the treatment of sleep apnea, sleep apnea syndrome, in particular obstructive sleep apnea or obstructive sleep apnea syndrome.
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| Method and device for the treatment of obstructive sleep apnea and snoring | 20120017920 | 20120126 |
| The device relates to methods and devices for the treatment of obstructive sleep apnea syndrome.
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| Method and device for the treatment of obstructive sleep apnea and snoring | 20120022389 | 20120126 |
| The device relates to methods and devices for the treatment of obstructive sleep apnea syndrome.
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| Methods for the treatment of respiratory depression | 20110003835 | 20110106 |
| This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic,... |
| Obstructive sleep apnea demonstration model device | 20100330546 | 20101230 |
| The present invention is an obstructive sleep apnea demonstration model device for a user and a patient. The device includes a vertical display stand with a horizontal base, a vertical front surface and a horizontal flange, a vertical side profile base with a removed oral cavity portion attached to the display stand and disposed within the horizontal flange, a top movable side piece with an upper lip, a set of upper teeth, a hinge and a palate. The device also includes a back elongated movable side piece disposed behind the top side piece that hinges on the palate, a chin assembly side piece with a chin, a lower lip, a set of lower teeth and a tongue and an intraoral appliance that is placed between the... |
| System for monitoring of and managing compliance with treatment for obstructive sleep apnea using oral appliance therapy and method therfor | 20100312484 | 20101209 |
| A system and method for monitoring of and managing compliance with treatment for obstructive sleep apnea using oral appliance therapy comprises a sensor module installed in an oral appliance, a data communications facility for communicating with the oral appliance, a control module, and a central database for storing data. Data stored on the sensor module is transferred to the data communications facility for local storage. The control module validates the locally stored temperature data and uploads the validated data into the central database. Temperature data stored in the central database may be viewed remotely via a secure computer network connection in graphical form by authorized users using role-based access controls. Authorized users may include the patient, the patient's provider, system administrators, and stake holders including insurance... |
| Oral tongue positioning device | 20100311008 | 20101209 |
| The invention relates to a device for positioning the tongue for the treatment of disorders including snoring and obstructive sleep apnoea (OSA) and OSA Syndrome, comprising an anchoring body (10) and means (13, 14, 15, 16, 17, 18) for retracting the tongue, said means being connected to said anchoring body. The tongue retracting means comprises at least two elongated arms arranged on a respective side of said anchoring body, and extending along different sides of the midline of the tongue. There is also provided a method of preventing Obstructive Sleep Apnea (OSA), comprising attaching tongue retracting means to permanently attached members in the tongue of a patient suffering from OSA at positions posterior of the tongue tip (apex), preferably to the corpus lingua and/or tongue root... |
| Oral respiration interface and a digital container | 20100311003 | 20101209 |
| The invention relates to oral appliances configured to maintain users upper airway unobstructed, facilitating improved breathing and elimination of snoring and obstructive sleep apnea. This invention covers mechanical and pneumatic means of maintaining users airway open. A smart container for appliances is also disclosed to be used in conjunction with any oral appliance as a system for wirelessly recording patient biofeedback, treatment compliance and live monitoring of the users medical condition.
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| Bicyclic amides for the treatment of respiratory depression | 20100286177 | 20101111 |
| This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic,... |
| 3-substituted-1,2,3-triazin-4-one's and 3 substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses | 20100267728 | 20101021 |
| This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic,... |
| Headgear pad for cpap interface | 20100258132 | 20101014 |
| The protective pad also incorporates a plurality of pairs of attachments extending from the opposite ends which facilitate the placement of the pad along the straps. Further, the invention provides color and design for an otherwise unattractive facial apparatus. Persons suffering from obstructive sleep apnea are often assigned this apparatus for therapy. The decorative quality improves the appearance and the attitude of the wearer thereby facilitating adjustment to a challenging change in lifestyle and thus improves compliance of therapy for this serious condition.
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| Toll-like receptor agonist regulation of vegf-induced tissue responses | 20100256085 | 20101007 |
| The present invention encompasses compositions and compounds as well as methods of their use for the regulation of a VEGF-induced tissue response. A VEGF-induced tissue response may include angiogenesis, inflammation, increased vascular permeability, increased vascular leak, hemorrhage, or mucus metaplasia. As such, the present invention encompasses methods of treating diseases where a VEGF-induced tissue response is part of the disease's clinical presentation. Specifically, the present invention provides compounds and compositions as well as methods for treating acute lung injury (ALI), acute respiratory distress syndrome (ARDS), asthma, chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), idiopathic pulmonary fibrosis (IPF), tuberculosis, pulmonary hypertension, pleural effusion, and lung cancer.
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| Sleep apnea therapy with naso-phyrangeal bypass | 20100242967 | 20100930 |
| Naso-pharyngeal devices for treating sleep apnea can perform two functions simultaneously: keeping an open airway through an inner lumen of the device; and support for the tissue in the airway, because keeping the tissue from completely collapsing creates the possibility of some air movement around the device in the critical areas associated with obstructive sleep apnea.
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| Implant systems and methods for treating obstructive sleep apnea | 20100234946 | 20100916 |
| A system for treating obstructive sleep apnea includes a body implantable in a soft palate, and a fastening element at a proximal end of the body for connecting the body with a hard palate. In one embodiment, the body is curved and has a convex top surface and a concave bottom surface. The curved body is adapted to support and/or change the shape of the soft palate for minimizing the likelihood of airway obstructions during sleep. The fastening element, secureable to the hard palate, includes at least one barb adapted to engage the hard palate for anchoring the body to the hard palate. In one embodiment, the body has a surface adapted to promote tissue in-growth. The implant body may be made of materials including nitinol,... |
| Sleep appliance | 20100224197 | 20100909 |
| A device for reducing snoring and/or sleep apnea comprising, in combination, a dental oral appliance, removably attached to a continuous positive airway pressure machine, to open the airway for a sleeping individual who suffers with snoring or obstructive sleep apnea, said dental oral appliance comprising, a body portion covering the inside of the upper teeth, said body having an open-palate, means to removably affix the appliance to the upper teeth, means to prevent occlusion of the upper and lower teeth, and a transpalatal bar that extends from the inside of the right teeth to the inside of the left teeth, to inhibit and restrain the tongue from upward and backward movement.
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| Apparatus for supplying gases to a patient | 20100218763 | 20100902 |
| The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature, of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.
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| Magnetic implants and methods for treating an oropharyngeal condition | 20100211184 | 20100819 |
| Magnetic devices and implantation methods are provided for use in the treatment of obstructive sleep apnea. The devices include a sheet-like element having ferromagnetic qualities. The device may also include a permanent magnet attached to the sheet-like element by magnetic forces. The devices are implanted in soft tissue surrounding the airway and in tissue space beneath the pharyngeal wall to exert forces on and/or change the shape of the soft tissue. The magnetic devices may also include a bladder containing a magnetorheological fluid that stiffens soft tissue when exposed to a magnetic field.
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| Treatment of obesity | 20100209385 | 20100819 |
| The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and signals via interaction with a gp130/LIF receptor heterodimer. In a related aspect, the present invention provides a method of increasing insulin sensitivity in a mammal. The method of present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by unwanted lipid accumulation (such as obesity, obesity induced-metabolic disorders, type II diabetes, dyslipidemia, glucose intolerance, insulin resistance, obstructive sleep apnea, cardiovascular disease or non-alcoholic fatty liver disease) or inadequate insulin sensitivity.
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| System and method for treating patient with obstructive sleep apnea | 20100206313 | 20100819 |
| A method for treating obstructive sleep apnea includes providing MAD therapy via an adjustable mandibular advancement device structured to advance the position of the patient's lower jaw, providing CPAP therapy via a mask system structured to deliver a supply of pressurized air to a patient, and selectively adjusting the mask system and/or the mandibular advancement device to alternate and/or balance between CPAP therapy and MAD therapy.
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| apparatus, system and method for therapeutic treatment of obstructive sleep apnea | 20100198306 | 20100805 |
| An implantable neurostimulator for treating obstructive sleep apnea comprises an implant configured to at least partially surround a Hypoglossal nerve (HGN) and a plurality of electrodes each attached to the implant. Each electrode configured to contact the HGN and electrically stimulate one or more regions or groups of the HGN.
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| Obstructive sleep apnea treatment devices, systems and methods | 20100174341 | 20100708 |
| Devices, systems and methods of neurostimulation for treating obstructive sleep apnea.
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| Bicyclic amide derivatives for enhancing glutamatergic synaptic responses | 20100173902 | 20100708 |
| This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord... |
| Method and device for treatment of obstructive sleep apnea | 20100139668 | 20100610 |
| This invention relates to devices and methods for maintaining upper airway patency during sleep for the treatment of sleeping disorders, upper airway resistance syndrome, snoring and obstructive sleep apnea.
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| Implant systems and methods for treating obstructive sleep apnea | 20100137905 | 20100603 |
| A system, method and kit for treating obstructive sleep apnea. The system includes a first implant adapted for implantation in an inframandibular region and having at least one aperture therethrough, and a ribbon-like element having first and second ends and a substantially uniform, non-circular cross section along its length. The ribbon-like element is adapted for implantation in a tongue with the first and second ends extending through the at least one aperture in the first implant for coupling the ribbon-like element with the first implant.
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| Implant systems and methods for treating obstructive sleep apnea | 20100132719 | 20100603 |
| A system for treating obstructive sleep apnea includes an anchoring element having scar tissue located in an inframandibular region, and a tongue implant having at least one arm extending therefrom, whereby the tongue implant is implantable in a tongue with the at least one arm being connectable with the anchoring element for coupling the tongue implant with the anchoring element. In one embodiment, the anchoring element includes a first implant part such as a flexible layer implantable in the inframandibular region and the scar tissue is formed on, in, and/or around the first implant part. The tongue implant is coupled with the anchoring element and/or the scar tissue through the at least one arm. The length of the at least one arm may be adjusted for... |
| Method of treating obstructive sleep apnea using electrical nerve stimulation | 20100131029 | 20100527 |
| A method for treating a medical condition, such as obstructive sleep apnea, includes the step of stimulating a nerve, particularly the hypoglossal nerve, using at least one of the following techniques: (a) continuous low-level electrical stimulation; (b) electrical stimulation synchronized with a physical process, such as inspiration, without feedback from the nerve being stimulated; and (c) intermittent electrical stimulation at controlled intervals based on the patient's metabolism.
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| Di-substituted amides for enhancing glutamatergic synaptic responses | 20100120764 | 20100513 |
| This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic,... |
| Implant systems and methods for treating obstructive sleep apnea | 20100108077 | 20100506 |
| A method of treating obstructive sleep apnea includes providing an elongated element having a central buttress area and first and second arms extending from opposite ends of the central buttress area. The method includes implanting the central buttress area in a tongue so that a longitudinal axis of the central buttress area intersects an anterior-posterior axis of the tongue. The first and second arms are advanced through the tongue until the first and second arms engage inframandibular musculature. Tension is applied to the first and second arms for pulling the central buttress area toward the inframandibular musculature for moving a posterior surface of the tongue away from an opposing surface of a pharyngeal wall. The first and second arms are anchored to the inframandibular musculature for... |
| Methods and devices for the indirect displacement of the hyoid bone for treating obstructive sleep apnea | 20100106246 | 20100429 |
| An implant for treating obstructive sleep apnea includes an elongated body having a central region, a first end, and a second end opposite the first end. The central region of the elongated body engages inframandibular musculature that extends between a mandible and a hyoid bone. The first and second ends of the elongated body are optionally anchored to the mandible. The elongated body is under tension for urging the inframandibular musculature in an inferior direction, which, in turn, pulls the hyoid bone anteriorly for minimizing the likelihood of occurrence of obstructive sleep apnea episodes.
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| Mouth-closing device for sleep disorder treatments | 20100095970 | 20100422 |
| The invention relates to devices designed to be used in conjunction with continuous positive airway pressure devices in order to improve the performance of the positive airway pressure in treating a disorder in breathing during sleep. In one embodiment, connection points on each side of both a maxillary and mandibular bite form are connected in order to maintain a space between the teeth substantially equal to the maximum intercuspal distance or space. Used with available continuous positive airway pressure devices, the invention can substantially improve obstructive sleep apnea or similar treatments with lower failure or patient non-compliance rates.
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| Method of stimulating a hypoglossal nerve for controlling the position of a patient's tongue | 20100094379 | 20100415 |
| A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.
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| Treatment of impaired respiratory function with gaboxadol | 20100093787 | 20100415 |
| The present invention relates to a method for treating impaired respiratory function in a human patient suffering from sleep apnea, such as central sleep apnea or obstructive sleep apnea, comprising administering to said patient an effective amount of gaboxadol per day.
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| Apparatus and method for treating obstructive sleep apnea | 20100087896 | 20100408 |
| The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position
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| Hyoid suspension for obstructive sleep apnea | 20090319046 | 20091224 |
| In an improved method for surgically treating a sleep-related breathing disorder, comprising hyoid distruction/expansion and hyo-mandibular suspension, an implant comprises a polypropylene and/or reticulated elastomeric biostable polyurethane matrix. The matrix is positioned between two or more segments of the distructed hyoid bone. A single or multiple midline or paramedian incisions are made under a patient's chin; soft tissues overlying the mandible are cleaned; a first screw is inserted into the edge of the mandible; a second screw is inserted into the inferior edge of the mandible; a second horizontal incision is made over the body of the hyoid; the infrahyoid muscles are separated from the body of the hyoid bone; the hyoid is refracted and stabilized; the sternohyoid and thyrohyoid muscles are detached from the body... |
| Very fast time resolved imaging in multiparameter measurement space | 20090318433 | 20091224 |
| The present invention provides new method of treatment of Parkinson's disease, obstructive sleep apnea, narcolepsy, dementia with Lewy bodies, vascular dementia with non-imidazole alkylamine derivatives that constitute antagonists of the H3-receptors of histamine.
... |
| Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity | 20090312435 | 20091217 |
| Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
... |
| Method and apparatus for providing positive airway pressure to a patient | 20090301488 | 20091210 |
| Methods and apparatus for treatment of medical disorders such as obstructive sleep apnea and congestive heart failure are disclosed. A method involves delivering pressurized air, oxygen or other breathing gas to a patient during a respiratory cycle, where pressure of the air is decreased according to an expiratory unloading factor during expiration. The timing and magnitude of the pressure change may be fully automated and responsive to feedback from a motor load sensor, optionally in combination with a pressure sensor.
... |
| Magnetic resonance imaging (mri) guided ablation | 20090264730 | 20091022 |
| Systems, methods, and other embodiments associated with tracking an ablative device and monitoring an ablation produced by the ablative device are described. One example method includes acquiring a magnetic resonance (MR) image of an ablative device inserted in a body and selectively controlling positioning of the ablative device based, at least in part on the MR image. The MR image may be continuously provided in real-time by an interventional MR imaging apparatus programmed to image using a tri-orthogonal plane sequence. The method may also include acquiring an MR image of an ablation performed by the ablative device, and selectively controlling the ablative device based, at least in part, on the MR image. The MR image may also be provided by the IMRI apparatus operating according to... |
| Real-time magnetic resonance imaging and peripheral arterial tone in sleep apnea diagnosis | 20090216108 | 20090827 |
| Obstructive sleep apnea diagnosis based on peripheral arterial tone (PAT) and real-time magnetic resonance imaging (MRI) is provided. PAT and other physiological data are used to identify respiratory events experienced by a subject with obstructive sleep apnea. MRI images are recorded at least during the respiratory events to identify airway obstructions responsible for the sleep apnea events. The MRI images are recorded in real-time at a high frame rate during the sleep apnea events. The PAT signals and MRI images are collected while the subject is in a sleep state. PAT signals can also be used to identify sleep apnea events and trigger an MRI device to begin recording, thereby reducing the costs associated with recording extraneous and large amounts of MRI data.
... |
| Real-time magnetic resonance imaging and peripheral arterial tone in sleep apnea diagnosis | 20090216108 | 20090827 |
| Obstructive sleep apnea diagnosis based on peripheral arterial tone (PAT) and real-time magnetic resonance imaging (MRI) is provided. PAT and other physiological data are used to identify respiratory events experienced by a subject with obstructive sleep apnea. MRI images are recorded at least during the respiratory events to identify airway obstructions responsible for the sleep apnea events. The MRI images are recorded in real-time at a high frame rate during the sleep apnea events. The PAT signals and MRI images are collected while the subject is in a sleep state. PAT signals can also be used to identify sleep apnea events and trigger an MRI device to begin recording, thereby reducing the costs associated with recording extraneous and large amounts of MRI data.
... |
| Real-time magnetic resonance imaging and peripheral arterial tone in sleep apnea diagnosis | 20090216108 | 20090827 |
| Obstructive sleep apnea diagnosis based on peripheral arterial tone (PAT) and real-time magnetic resonance imaging (MRI) is provided. PAT and other physiological data are used to identify respiratory events experienced by a subject with obstructive sleep apnea. MRI images are recorded at least during the respiratory events to identify airway obstructions responsible for the sleep apnea events. The MRI images are recorded in real-time at a high frame rate during the sleep apnea events. The PAT signals and MRI images are collected while the subject is in a sleep state. PAT signals can also be used to identify sleep apnea events and trigger an MRI device to begin recording, thereby reducing the costs associated with recording extraneous and large amounts of MRI data.
... |
| Real-time magnetic resonance imaging and peripheral arterial tone in sleep apnea diagnosis | 20090216108 | 20090827 |
| Obstructive sleep apnea diagnosis based on peripheral arterial tone (PAT) and real-time magnetic resonance imaging (MRI) is provided. PAT and other physiological data are used to identify respiratory events experienced by a subject with obstructive sleep apnea. MRI images are recorded at least during the respiratory events to identify airway obstructions responsible for the sleep apnea events. The MRI images are recorded in real-time at a high frame rate during the sleep apnea events. The PAT signals and MRI images are collected while the subject is in a sleep state. PAT signals can also be used to identify sleep apnea events and trigger an MRI device to begin recording, thereby reducing the costs associated with recording extraneous and large amounts of MRI data.
... |
| Real-time magnetic resonance imaging and peripheral arterial tone in sleep apnea diagnosis | 20090216108 | 20090827 |
| Obstructive sleep apnea diagnosis based on peripheral arterial tone (PAT) and real-time magnetic resonance imaging (MRI) is provided. PAT and other physiological data are used to identify respiratory events experienced by a subject with obstructive sleep apnea. MRI images are recorded at least during the respiratory events to identify airway obstructions responsible for the sleep apnea events. The MRI images are recorded in real-time at a high frame rate during the sleep apnea events. The PAT signals and MRI images are collected while the subject is in a sleep state. PAT signals can also be used to identify sleep apnea events and trigger an MRI device to begin recording, thereby reducing the costs associated with recording extraneous and large amounts of MRI data.
... |
| Method and apparatus to detect and monitor the frequency of obstructive sleep apnea | 20090209880 | 20090820 |
| The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus includes an intracardiac impedance sensor to measure intracardiac impedance, a movement sensor to measure an amount of movement of a patient, and a controller operatively coupled to said intracardiac impedance sensor and said movement sensor, said controller adapted to receive at least one of an intracardiac impedance and the amount of movement of the patient and detect obstructive sleep apnea based upon said intracardiac impedance and said movement.
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| Method and apparatus to detect and monitor the frequency of obstructive sleep apnea | 20090209880 | 20090820 |
| The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus includes an intracardiac impedance sensor to measure intracardiac impedance, a movement sensor to measure an amount of movement of a patient, and a controller operatively coupled to said intracardiac impedance sensor and said movement sensor, said controller adapted to receive at least one of an intracardiac impedance and the amount of movement of the patient and detect obstructive sleep apnea based upon said intracardiac impedance and said movement.
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| Dental appliance | 20090178684 | 20090716 |
| The present invention is a dental oral appliance to open the airway for a sleeping individual who suffers with snoring or obstructive sleep apnea. The appliance includes a base to secure the appliance within the mouth for the individual. Typically, the base will fit over and secure to the lower teeth of the individual. The appliance also includes a tongue restraining device connected to the base. The tongue restraining device has a substantial breach formed therein to permit movement of the tongue so that the user can more easily swallow saliva. A ramp might also be attached to the anterior portion of the base to advance the mandible.
... |
| Cpap system and method of use | 20090173344 | 20090709 |
| A system and method for treating obstructive sleep apnea(OSA) by means of a Continuous Positive Airway Pressure(CPAP) system in which is included an ultra-violet light source to remove bacteria and contaminants which may cause respiratory infection in a patient being treated. The ultravoilet light source is contained in a specially designed chamber comprising aluminum or equivalent suitable materials. The ultraviolet chamber is positioned directly downstream of a humidification unit and includes specially positioned baffles to protect connecting elements and other system components from any possible damage.
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| Partially erodable systems for treatment of obstructive sleep apnea | 20090177027 | 20090709 |
| The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material. The deformable portion of the device has a preferred shape that corresponds to the desired final shape of the device once placed in an airway. In making a transplant-ready device, however, the deformable portion is placed into a deformed shape and constrained in that shape by the bioerodible material. After implantation, the device gradually assumes the preferred shape as the constraining bioerodible material erodes. As the device gradually reforms toward the preferred shape, it reforms the tissue into the therapeutically desirable... |
| Sleep apnea prevention and relief device | 20090177124 | 20090709 |
| A sleep apnea prevention and relief device is provided that is useful for a patient diagnosed with obstructive sleep apnea. For example, a form-fitting neck device is provided with a suction generation or creation means to create continuous or lasting negative pressure upon or around the neck in order to urge substantially outward expansion of the soft tissues that are compressing the pharynx and creating the obstruction.
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| Parameter optimization in sleep apnea treatment apparatus | 20090151725 | 20090618 |
| The present invention includes a method and apparatus for the optimized treatment of obstructive sleep apnea. The present invention includes a pressure source configured to provide positive airway pressure to a patient who is resting at home. The pressure source receives control signals from control electronics that define a pressure profile to be delivered to the patient. The control electronics select parameters to define the pressure profile based on factors such as a user selection, information received from a sensor, and/or a prescription.
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| Inhibitors of the task-1 and task-3 ion channel | 20090149496 | 20090611 |
| The invention relates to the use of Kv1.5 inhibitors for the therapy or prophylaxis of respiratory disorders, sleep-related respiratory disorders, central and obstructive sleep apneas, upper airway resistance syndrome, Cheyne-Stokes respiration, snoring, disrupted central respiratory drive, sudden child death, postoperative hypoxia and apnea, muscle-related respiratory disorders, respiratory disorders after long-term ventilation, respiratory disorders during adaptation in high mountains, acute and chronic lung disorders with hypoxia and hypercapnia, neurodegenerative disorders, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cancer disorders, breast cancer, lung cancer, colon cancer and prostate cancer.
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| Tongue grasping and restraining apparatus and methods | 20090126742 | 20090521 |
| A tongue grasping and restraining device holds the tongue securely during sleep in order to minimize the risk of the tongue slipping back and blocking the throat, a condition known as obstructive sleep apnea. Plural tongue gripping projections are coupled to upper and lower supports. The projections engage and hold the tongue. The upper and lower supports are biased toward one another into a tongue engaging position. The upper support is coupled to the user's upper jaw, for example, to a denture, dental appliance or by upper teeth engaging mechanisms. The lower support can be hinged or otherwise joined to the upper support or can be separate therefrom. A tube and rod mechanism in one embodiment couples the upper and lower supports together. Exemplary methods of... |
| Sleep appliance | 20090120448 | 20090514 |
| A dental oral appliance for use with patients who suffer with sleep disorders, to reduce or eliminate snoring or obstructive sleep apnea and to open the airway for a sleeping patient. Retention for the appliance is provided by an occlusal coverage of the upper or lower teeth. A raised incisor ramp (110) that extends from the incisal tip of the incisor toward the lingual, or posterior ramps, separate the posterior teeth to open the airway. A transpalatal member (28), which extends from the lingual of the right molars to the lingual of the left molars, inhibits the upward and backward movement of the tongue. The tranpalatal member may be curved and may slidably fit in the body of the appliance. A posterior tongue restrainer may be... |
| Method and apparatus for improved flow limitation detection of obstructive sleep apnea | 20090078256 | 20090326 |
| In a respiratory apparatus for treatment of sleep apnea and other disorders associated with an obstruction of a patient's airway and which uses an airflow signal, an obstruction index is generated which detects the flattening of the inspiratory portion of the airflow. The flattening index serves as an obstruction index used to differentiate normal and obstructed breathing. The obstruction index is based upon comparison of values of airflow in different sectors of the inspiratory peak of the wave function and is particularly suitable for distinguishing M shaped or square shaped respiratory patters indicative of partially obstructed airways.
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| Auto-titration of positive airway pressure machine with feedback from implantable sensor | 20090078257 | 20090326 |
| Systems and methods for detecting and treating an obstructive sleep apnea event are disclosed herein. The systems and methods may use an electrical output generating ionic polymer metal composite sensor attached to a region in an airway passage in an oral cavity. The electrical output may be wirelessly transmitted as a signal for indication of an obstructive sleep apnea event. The signal may be further analyzed by a positive airway pressure system for treatment of the obstructive sleep apnea event.
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| Smart mandibular repositioning system | 20090078273 | 20090326 |
| Systems and methods for detecting an obstructive sleep apnea event are disclosed herein. The systems and methods may use an electrical output generating ionic polymer metal composite sensor attached to a region in an airway passage in an oral cavity. The electrical output may be wirelessly transmitted as a signal for indication of an obstructive sleep apnea event. The signal may be further processed by a smart mandibular repositioning system for treatment of the obstructive sleep apnea event.
... |
| Implantable obstructive sleep apnea sensor | 20090078274 | 20090326 |
| Systems and methods for detecting an obstructive sleep apnea event are disclosed herein. The systems and methods may use an electrical output generating ionic polymer metal composite sensor attached to a region in an airway passage in an oral cavity. The electrical output may be wirelessly transmitted as a signal for indication of an obstructive sleep apnea event. The signal may be further analyzed for treatment of the obstructive sleep apnea event.
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| Parameter optimization in sleep apnea treatment apparatus | 20090065004 | 20090312 |
| The present invention includes a method and apparatus for the optimized treatment of obstructive sleep apnea. The present invention includes a pressure source configured to provide positive airway pressure to a patient who is resting at home. The pressure source receives control signals from control electronics that define a pressure profile to be delivered to the patient. The control electronics select parameters to define the pressure profile based on factors such as a user selection, information received from a sensor, and/or a prescription.
... |
| Sleep appliance | 20090056724 | 20090305 |
| A dental oral appliance for use with patients who suffer with sleep disorders, to reduce or eliminate snoring and to open the airway for a sleeping individual who suffers with obstructive sleep apnea. The appliance covers the inside (lingual) of the upper teeth and has an open palate. Retention for the appliance is provided by either clasps placed over the upper right and left molars and a retainer in the anterior area or by an occlusal coverage of the upper teeth. A raised incisor ramp that extends from the incisal tip (biting edge) of the incisors toward the lingual, or posterior raised ramps, separate the posterior teeth to reduce spasm on the temporalis muscle. A transverse, transpalatal member, which extends from the inside (lingual) of the... |
| Thio-substituted biarylmethanesulfinyl derivatives | 20090062284 | 20090305 |
| wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.
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| Respiratory device for treating obstructive sleep apnea and method for controlling said device | 20090020122 | 20090122 |
| The use of a respiratory device of this type for the treatment of sleep apnea substantially decreases the strain on the respiratory musculature of the patient, makes the course of treatment more pleasant, and decreases potential secondary effects of the treatment.
... |
| Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity | 20090023765 | 20090122 |
| Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
... |
| Method and device for the treatment of obstructive sleep apnea and snoring | 20090014012 | 20090115 |
| The device relates to methods and devices for the treatment of obstructive sleep apnea syndrome.
... |
| Grooved electrode and wireless microtransponder system | 20080319506 | 20081225 |
| A grooved electrode adapted for interfacing cellular matter is provided. The grooved electrode includes grooves adapted for electrically interfacing the grooved electrode with cellular matter growing along the body of the grooved electrode. Further, the grooved electrode includes a wireless transponder adapted to electrically interface with cellular matter and to relay such interactions via RF signals. The RF signals received by the wireless transponder are modulated in response to electrical signals generated by the cellular matter, which are detected by the transponder. The grooved electrode may be implanted within peripheral nerves for treating various neurological conditions, which may include nerve rehabilitation and prosthetic actuation, severe pain, obstructive sleep apnea and so forth.
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| Device for treating snoring sounds, interruptions in breathing and obstructive sleep apnea | 20080289637 | 20081127 |
| The invention relates to a device (1) for treating snoring sounds, interruptions in breathing and obstructive sleep apnea (OSA) and for diagnosing and treating obstructions and vibrations in the pharyngeal region, with the device (1) being used intra-orally. The device (1) is comprised of at least one oral transverse (2a, 2b) and of means (3) which are placed at the rear end of the oral transverse (2a, 2b) for stabilizing the velum; the means (3) can be individually adapted to the patient's anatomy; during intra-oral use of the device (1), the velum is held at a distance from the pharyngeal wall and the connective tissue in the upper pharynx behind the velum is stabilized in order to prevent obstructions. Different means can advantageously complement the device... |
| Methods and compositions for treating sleep-related breathing disorders | 20080293823 | 20081127 |
| Provided herein are methods of treating a sleep-related breathing disorder, such as obstructive sleep apnea, comprising the administration of O-desmethylvenlafaxine or duloxetine.
... |
| Method and device for the treating sleep apnea | 20080276938 | 20081113 |
| An improved treatment of obstructive sleep apnea is disclosed. A method and various device combinations are presented. The device combinations describe optimal adjustments to properly position a nasal pillow in each of a patient's nares. A novel swivel joint is described to which a nasal pillow is slip-fit over. The swivel joint prevents loss of a proper seal between the nasal pillow and nare which may otherwise occur as a result of head movement. Also presented is an improved obturator mouthpiece design which substantially eliminates air flow through the oral cavity resulting from leakage in the oropharynx.
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| Device to treat snoring and obstructive sleep apnea in adults and to prevent infants from sleeping non-supine | 20080264426 | 20081030 |
| This is a position sensing monitor that provides private sensory biofeedback to adults, in the form of auditory stimulus or tactile sensation (vibration), to promote non-supine sleep. The essential feature of this invention is to eliminate/reduce position-related snoring and obstructive sleep apnea and not disrupting sleep of bed partner. A variation of this concept is its use in infants to promote sleeping supine by parental notification of rolling from supine to side or prone positions, allow re-position to supine and thereby reducing the risk for SIDS.
... |
| Method and apparatus for treatment of snoring and sleep apnea | 20080264427 | 20081030 |
| An anti-snoring device that attaches to a specific area of the neck. The attachment means can be an adhesive, a clip or an implant. The device exerts a predetermined pulling force on this area of the neck, causing this area of the neck to expand outward from its normal position. This expansion opens a blockage in the throat of a sleeping person, thereby eliminating snoring and helping some people with obstructive sleep apnea.
... |
| Treatment of impaired respiratory function with gaboxadol | 20080269278 | 20081030 |
| The present invention relates to a method for treating impaired respiratory function in a human patient suffering from sleep apnea, such as central sleep apnea or obstructive sleep apnea, comprising administering to said patient an effective amount of gaboxadol per day.
... |
| Emergency and mass casualty ventilator | 20080257348 | 20081023 |
| This invention pertains generally to ventilation devices, and more particularly to a low cost constant pressure, variable flow blower powered ventilation device that is fully functional with a mask and which can be adapted to a number of applications including (1) a respiratory device used for automatic resuscitation of patients needing emergency ventilation, (2) emergency backup ventilation capabilities for hospitals and other healthcare institutions, and (3) positive pressure support therapy for patients suffering from obstructive sleep apnea among other diseases and respiratory conditions.
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| Method and means of preventing and treating sleep disordered breathing | 20080261931 | 20081023 |
| A method of treating or preventing snoring, obstructive sleep apnea (OSA) and/or central sleep apnea (CSA) comprises administering a pharmacologically effective amount a salt of acetylhomotaurine (AcHT) such as calcium acamprosate (CA) to a patient. Also disclosed is the use of AcHT and CA for the manufacture of a medicament for treating or preventing snoring, OSA and/or CSA and of a diagnostic device, kit or composition; a protective patch comprising AcHT or CA; and a pharmaceutical composition comprising AcHT or CA and an agent capable of alleviating the effects of snoring OSA and/or CSA, in combined amounts effective in the treatment of snoring OSA and/or CSA, and a carrier.
... |
| Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity | 20080234257 | 20080925 |
| Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.
... |
| Method and apparatus for treating airway obstruction | 20080223367 | 20080918 |
| Methods and Devices for treating airway openings and breathing disorders including obstructive sleep apnea are disclosed. Structures and methods disclosed herein maintain and preserve airway openings against posterior collapse of the tongue.
... |
| Flow diverter for controlling the pressure and flow rate in cpap device | 20080210237 | 20080904 |
| A flow diverter valve is used in controlling the pressure and/or flow rate of a breathable gas supplied to the airways of a patient by a breathable gas flow generator supply apparatus during, for example, ventilatory assistance treatments such as non-invasive positive pressure ventilation and nasal Continuous Positive Airway Pressure (CPAP) treatment of Obstructive Sleep Apnea. The flow diverter valve includes a vane and a housing. The housing has an inlet port, an outlet port, and an exhaust port. The exhaust port opens to atmosphere, and the inlet port is in fluid communication with the flow generator. The outlet port is in fluid communication with a patient mask via a conduit. The vane is configured with respect to the housing such that a blower associated with... |
| Sleep appliance | 20080210244 | 20080904 |
| A dental oral appliance to reduce or eliminate snoring or obstructive sleep apnea and to open the airway for a sleeping patient. The appliance covers the inside (lingual) of the upper or lower teeth and has an open palate. Retention for the appliance is provided by an occlusal coverge of the upper or lower teeth. A raised incisor ramp that extends from the incisal tip of the incisors toward the lingual, or posterior ramps, separate the posterior teeth to open the airway. A transpalatal bar, which extends from the inside (lingual) of the right molars to the inside of the left molars, inhibits the upward and backward movement of the tongue. An anterior tongue restrainer which is attached to the transpalatal bar at one end and... |
| Method and apparatus for treating sleep apnea and snoring | 20080195173 | 20080814 |
| A method and device for treating snoring and obstructive sleep apnea, in which one sensor senses the onset of an episode of snoring or sleep apnea and causes production of an electrical stimulating signal consisting of a combination of direct current and a train of alternating pulses, with the respective functions of opening up restricted airway passages by stimulation of related muscle groups and eliciting a response of partial arousal, in which the condition is corrected. The onset of the episodes is sensed by an acoustic transducer, the episodes being differentiated by their unique acoustical signature by means of appropriate signal processing, the acoustical transducer also carrying one of two stimulation electrodes, which are held in light contact against the throat of the subject by means... |
| System and method for treating a patient with obstructive sleep apnea | 20080173312 | 20080724 |
| A method for treating obstructive sleep apnea includes providing MAD therapy via an adjustable mandibular advancement device structured to advance the position of the patient's lower jaw, providing CPAP therapy via a mask system structured to deliver a supply of pressurized air to a patient, and selectively adjusting the mask system and/or the mandibular advancement device to alternate and/or balance between CPAP therapy and MAD therapy.
... |
| Head positioning device for treatment of sleep apnea | 20080156332 | 20080703 |
| A user or assistant operated device for elevation and forward thrusting of the jaw for mild to moderate obstructive sleep apnea is disclosed. The device includes a base configured to contact a torso of a wearer, a chin support configured to contact a jaw of the wearer, and a jack extending between the base and the chin support. In this regard, the jack is length adjustable and configured to elevate the chin support relative to the base such that the jaw is thrust forward relative to the torso.
... |
| Awake airway, including two variants | 20080149110 | 20080626 |
| The Awake Airway is an oral device designed with two arches to gently hold both the maxillary and mandibular dental arches in a fixed position angled slightly open in such a way as to not stimulate any part of the oral cavity or oropharynx so a fully wide awake user would tolerate it. It would be made of a resilient material such as a soft plastic with a foam insert to hold the teeth or edentulous arches. It is shaped to conform to the teeth and maxillary and mandibular anatomy, and easily inserted by the user him/herself. By gently maintaining the mouth slightly open it would enhance the patency of the airway. It's usefulness would include that of a clinical airway in awake to sedated or... |
| Awake airway: a glossal variant | 20080149114 | 20080626 |
| The Awake Airway is an oral device designed with two arches to gently hold both the maxillary and mandibular dental arches in a fixed position angled slightly open in such a way as to not stimulate any part of the oral cavity or oropharynx so a fully wide awake user would tolerate it. It would be made of a resilient material such as a soft plastic with a foam insert to hold the teeth or edentulous arches. It is shaped to conform to the teeth and maxillary and mandibular anatomy, and easily inserted by the user him/herself By gently maintaining the mouth slightly open it would enhance the patency of the airway. The mandibular (jaw) thrust feature capitalizes on the unique anatomy of the human tempormandibular... |
| Awake airway: mandibular (jaw) thrust feature to enhance a patent airway | 20080153056 | 20080626 |
| The Awake Airway is an oral device designed with two arches to gently hold both the maxillary and mandibular dental arches in a fixed position angled slightly open in such a way as to not stimulate any part of the oral cavity or oropharynx so a fully wide awake user would tolerate it. It would be made of a resilient material such as a soft plastic with a foam insert to hold the teeth or edentulous arches. It is shaped to conform to the teeth and maxillary and mandibular anatomy, and easily inserted by the user him/herself. By gently maintaining the mouth slightly open it would enhance the patency of the airway. The mandibular (jaw) thrust feature capitalizes on the unique anatomy of the human tempormandibular... |
| Awake airway: non-stimulating (non-gagging) feature | 20080153057 | 20080626 |
| The Awake Airway is an oral device designed with two arches to gently hold both the maxillary and mandibular dental arches in a fixed position angled slightly open in such a way as to not stimulate any part of the oral cavity or oropharynx so a fully wide awake user would tolerate it. It would be made of a resilient material such as a soft plastic with a foam insert to hold the teeth or edentulous arches. It is shaped to conform to the teeth and maxillary and mandibular anatomy, and easily inserted by the user him/herself. By gently maintaining the mouth slightly open it would enhance the patency of the airway. It's usefulness would include that of a clinical airway in awake to sedated or... |
| Method and device for improving efficiency of breathing | 20080142014 | 20080619 |
| A system for treating respiratory disease, obstructive sleep apnea (OSA) and snoring and for improving breathing efficiency is described. In one embodiment, the system includes a valve system having a first valve adapted to be positioned over a person's mouth and a second valve adapted to be positioned over a person's nose. The valves are selected such that in one application the valve system allows the person to inhale through the nose only and exhale through the mouth only while in another application the valve system allows the person to exhale through the nose only and inhale through the mouth only.
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| Apnea risk evaluation system - automated prediction of risk for perioperative complications | 20080146893 | 20080619 |
| A system for predicting risk for perioperative complications is described including a user device for receiving a set of risk factors to determine perioperative complications for a patient including patient data useful to determine the likelihood of obstructive sleep apnea. The system also includes an acquisition module to receive data from an obstructive sleep apnea sleep study of the patient. Further a determination module can determine the severity of obstructive sleep apnea for the patient. The system can also include an analysis module having a predictive model that incorporates one or more prediction equations for predicting perioperative complications derived from one or more databases having multiple patient data relevant to predict perioperative complications. The analysis module can be configured to apply the one or more prediction... |
| Rfid-based apparatus, system, and method for therapeutic treatment of obstructive sleep apnea | 20080109046 | 20080508 |
| Provided is an implantable RFID-enabled micro-electronic neurostimulator system for treating obstructive sleep apnea, comprising an implant having a top and a bottom layer, the bottom layer serving as an attachment mechanism such that the bottom layer of the implant encompasses the hypoglossal nerve and attaches to the top layer of the implant; a printed circuit board (PCB) attached to the top layer of the implant, the PCB having a first and a second opposing sides; a neural interface attached to the second side of the PCB; a core subsystem (CSS) attached to the first side of the PCB and electrically connected to the neural interface; and a radio frequency (RF) interface attached to the first side of the PCB and electrically connected to the CSS, wherein... |
| Obstructive sleep apnea treatment devices, systems and methods | 20080103407 | 20080501 |
| Devices, systems and methods for nerve stimulation for OSA therapy.
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| Obstructive sleep apnea treatment devices, systems and methods | 20080103545 | 20080501 |
| Devices, systems and methods for nerve stimulation for OSA therapy.
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| Tongue implant for sleep apnea | 20080078411 | 20080403 |
| A patient's obstructive sleep apnea is treated by identifying a patient with sleep apnea attributable at least in part to movement of a base of a tongue of said patient toward a pharyngeal wall of said patient. The method includes identifying a region in the tongue extending from a mandibular-geniohyoid interface to the base of the tongue and stiffening a tissue of the tongue throughout the identified region.
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| Tongue implant | 20080078412 | 20080403 |
| A patient's obstructive sleep apnea is treated by identifying a patient with sleep apnea attributable at least in part to movement of a base of a tongue of the patient toward a pharyngeal wall of the patient. The tongue is stiffened by an implant sized to be placed within the tongue. A distal portion of the implant is sized to extend within the tongue from a first end near a mandibular-geniohyoid interface to a second end near a base of the tongue. A proximal portion is attached to the first end and adapted to be secured to a jaw bone of the patient following a period of healing after placement of the implant in the tongue.
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| Managing obstructive sleep apnea and/or snoring using local time released agents | 20080082041 | 20080403 |
| A method for managing at least one breathing condition may include storing an agent near a patient's airway and delivering the agent to the mucosal tissue in the pharyngeal area in a time-released manner during a sleep period. The delivered agent may cause increased contraction of muscle tissue in the pharyngeal area.
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| Airway implants and methods and devices for insertion and retrieval | 20080066769 | 20080320 |
| Embodiments of the present invention relate to methods and devices for the treatment of airway obstruction, such as obstructive sleep apnea, and devices and methods that facilitate insertion and retrieval of the same. In one embodiment, disclosed is a tissue tensioner that includes an elongate flexible tether having a first end and a second end, a bone anchor configured to be connected to a patient's mandible, a tissue ingrowth implant configured to be implanted in a patient's tongue and connected to the second end of the tether, and an adjustment mechanism configured to be held by the bone anchor adjacent the patient's mandible and configured to receive the first end of the tether and configured to adjust tension in the flexible tether between the patient's mandible... |
| Method and apparatus for providing positive airway pressure to a patient | 20080053442 | 20080306 |
| A system including methods and apparatus for treatment of a medical disorder such as obstructive sleep apnea or congestive heart failure. The system involves applying a gain to flow rate of pressurized gas delivered to a patient during inspiratory and/or expiratory phases of a respiratory cycle to deliver the pressurized gas in proportion to the respective gains during inspiration and/or expiration. A base pressure may be applied in addition to the gain-modified pressures and an elevated pressure profile may be employed to assist or control inspiration. The system may be fully automated responsive to feedback provided by a flow sensor that determines the estimated patient flow rate. A leak computer can be included to instantaneously calculate gas leakage from the system. The system may be utilized... |
| Stiffening procedure for sleep apnea | 20070295340 | 20071227 |
| A patient's obstructive sleep apnea is treated by placing a fibrosis-inducing agent is placed within the tongue in a region extending substantially from a hyoid bone rearward toward a back surface of the tongue and upwardly along the back wall toward a free end of a soft palate of the patient.
... |
| Oral appliance for treatment of snoring and sleep apnea | 20070292819 | 20071220 |
| An oral appliance is provided for the treatment of snoring and obstructive sleep apnea. The oral appliance includes an upper tray adaptable to conform to a user's maxillary dentition and a plurality of lower trays, each of the lower trays adaptable to conform to the user's mandibular dentition. At least some of the lower trays are structured to engage the upper tray, each of the lower trays are structured to impart a different fixed amount of mandibular advancement.
... |
| Positive airway pressure device | 20070283958 | 20071213 |
| A new Continuous/Bi-Level Positive Airway Pressure device (C/BiPAP) is operable to deliver breathing gas such as air, oxygen or a mixture thereof at relatively higher and lower pressures (i.e., generally equal to or above ambient atmospheric pressure) to a patient either as preset or in proportion to the patient's respiratory flow for treatment of Obstructive Sleep Apnea Syndrome (OSAS). The device can be for a single patient or a Dual C/BiPAP having similar elements to the C/BiPAP. A control system can receive inputs for a delta coefficient. The delta coefficient allows a medical professional or the user to designate a stepwise or segmented increase or decrease in pressure from the start of the treatment and/or during the treatment. The C/BiPAP can also include a humidifier, a... |
| Method and apparatus for treating obstructive sleep apnea by using negative oral pressure to a patient | 20070277818 | 20071206 |
| The present invention provides a method and apparatus for treating obstructive sleep apnea by using negative oral pressure to a patient. The present apparatus includes a vacuum unit for controlling and maintaining negative pressure of an oral cavity of the patient, a tube with one end thereof connecting to the vacuum unit to suck out air in the oral cavity to generate the negative pressure therein, and a mouthpiece connecting to the other end of the tube and fitting into and sealing the patient's mouth to prevent the oral cavity from air leakage. By using negative pressure in the oral cavity, the patient's soft palate is pulled toward the oral cavity and the patient's tongue is pulled toward an upper palate so as to maintain the... |
| Method of treating and diagnosing sleep disordered breathing and means for carrying out the method | 20070281005 | 20071206 |
| A method of treating or preventing Obstructive Sleep Apnea (OSA) comprises the administration of a pharmacologically effective amount of zonisamide to a patient in need thereof, with the proviso that OSA caused by external mechanical obstruction of the airways, such as by mucus, is excluded. Also disclosed is the use of zonisamide for the manufacture of a medicament useful in the treatment; a protective patch comprising zonisamide and a pharmaceutically acceptable carrier for transdermal or transmucosal administration to a person suffering from OSA; and the use of zonisamide for the manufacture of a diagnostic device, kit or composition for the diagnosis of sleep disordered breathing.
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| Two-tier model to screen patients with sleep-disordered breathing | 20070265506 | 20071115 |
| A two tier model for screening patients with sleep-disordered breathing includes collecting clinical information of a number of patients are collected, including gender, age, and body mass index, and performing form surveys including the Epworth Sleepiness Scale and the Snore Outcomes Survey to obtain a respiratory disturbance index (RDI). Receiver operating characteristics (ROC) are calculated with an initial strategy to maximize prediction sensitivity for patients with obstructive sleep apnea syndrome(OSAS). The associations between pulse oximeter data (desaturation index of 3%, DI3) against RDI was the second strategy to maximize prediction specificity.
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| Method and apparatus for fractional light-based treatment of obstructive sleep apnea | 20070265606 | 20071115 |
| An apparatus and method are described that uses fractional light based treatment to shrink soft tissue in the mouth or throat to reduce obstruction of the airways for patients suffering from obstructive sleep apnea. A light delivery probe with scanning optics can be used to deliver treatment. Cooling systems can be added to reduce damage to epithelial layers of tissue. Light based treatment can be nonablative or ablative and is preferably performed with a laser.
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| Devices for treating obstructive sleep apnea and/or snoring | 20070256695 | 20071108 |
| A garment for the treatment of sleep apnea and/or snoring includes a member for attachment to an individual afflicted with sleep apnea and an elongate, position control member at the rear of the garment and extending outwardly therefrom. The elongate member is a continuous member having transversely spaced-apart side surfaces, and the side surfaces are joined to an outer wall of the position control member at elongate side edges. The side surfaces and/or side edges are located to engage a mattress or other sleeping surface when an individual wearing the garment is sleeping in a lateral position to aid in supporting the individual in a lateral position.
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| System and method of predicting efficacy of tongue-base therapies | 20070239056 | 20071011 |
| A method, computer-readable medium, and system for predicting a response to tongue-base therapies (particularly as it relates to obstructive sleep apnea) are provided. The method includes generating with a processing element a plurality of images of at least a portion of a patient's anatomy, acquiring data indicative of the portion of the patient's anatomy from the images, and determining a probability of a patient's response to a tongue-base treatment based on the acquired data.
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| Snoring treatment apparatus and methods of managing snorers | 20070215156 | 20070920 |
| Method and apparatus are provided for the treatment of a user's sleeping disorder, e.g., snoring. Positive pressure gas in the range of 8 cm H2O or less, preferably about 3-6 cm H2O, is provided to the user's airways. If the pressure is greater than 6 cm H2O, or between 6-8 cm H2O, an indication or alert is provided to treat or diagnose the user with obstructive sleep apnea (OSA).
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| Inventory and patient management system | 20070198357 | 20070823 |
| A system and/or method for managing patients and products used in the treatment of their sleep-disordered breathing (SDB) is provided. A barcode scanner preferably scans product data and wirelessly communicates it to a database for use in an inventory management system for tracking and generating product and patient information for Obstructive Sleep Apnea (OSA) treatment, for example, when receiving items into stock, dispensing products, returning loaned, rented, and/or defective products, etc. Custom patient reminders, notes, reports, and the like may be generated automatically based on the scanned data.
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| Method and apparatus for preventing obstructive sleep apnea | 20070173893 | 20070726 |
| A method and device for creating an afferent stimulus for preventing obstructive sleep apnea are disclosed. The device includes at least one electrode and a stimulator, of which at least one electrode stimulates the genioglossus muscle of a patient having obstructive sleep apnea. The electrode is capable of conducting selected electrical stimulation generated by the stimulator, and the system is capable of delivering the selected electrical stimulation during a selected time of day. The electrical stimulation is selected to maintain sufficient muscle tone of the genioglossus muscle to prevent it from obstructing the airway during sleep, preferably at a stimulus intensity low enough to avoid awakening the patient during sleep. A removable mouthpiece having a battery, at least one electrode, and a controller, and optionally a... |
| Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity | 20070155820 | 20070705 |
| Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
... |
| System to prevent airway obstruction | 20070144534 | 20070628 |
| Devices and methods are provided for the treatment of obstructive sleep apnea. An implantable device is inserted into the tongue. The implantable device is a flexible elongated structure, which may be a curved or jointed filament; of a sufficient length and diameter to provide support, when implanted, sufficient to restrain obstructive movement of the tongue during sleep.
... |
| Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity | 20070149622 | 20070628 |
| Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
... |
| Sleep disorder screening program | 20070129644 | 20070607 |
| A method of screening for the risk of a sleep disorder such as obstructive sleep apnea proceeds by first providing a sleep health education to a member of an organization, offering and following up by providing a portable screening device for use by the member at home, which monitors a respiratory parameter such as airflow and/or oxygen saturation. The data from the monitoring is then analysed to determine the presence of the sleep disorder and the results are then reported.
... |
| Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties | 20070112031 | 20070517 |
| Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
... |
| Intraoral mandibular advancement device for treatment of sleep disorders, including snoring, obstructive sleep apnea, and gastroesophageal reflux disease and method for delivering the same | 20070079833 | 20070412 |
| An intraoral mandibular advancement device to treat problems associated with sleep disorders in a user having an obstructed airway, the disorders including, without limitation, snoring, obstructive sleep apnea, gastroesophageal reflux disease and/or bruxism having a main body for attachment to the user's mouth and having a central portion; a protrusive element distending from the central portion of the main body such that when worn by the user the element causes mandibular advancement sufficient to expand the oropharangeal space and reduce the obstruction; and a retainer extending from the main body for retention of the device in the user's mouth when worn during the user's sleep state. The main body is either complimentary with the user's palate and lingual surfaces of the maxillary teeth, rests against the... |
| Method and apparatus useful in the diagnosis of obstructive sleep apnea of a patient | 20070051371 | 20070308 |
| Patients may operate a CPAP system to deliver appropriate airway pressure at their home. A patient's apnea problem can be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
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| Formulations for alteration of biophysical properties of mucosal lining | 20070053844 | 20070308 |
| Conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment, and methods of use, have been developed. One or more active agents, such as antivirals, antimicrobials, anti-inflammatories, proteins or peptides, may optionally be included with the formulation. The active agent may be administered with or incorporated into the formulation, or may be administered after the conductive formulation is administered. When applied to mucosal lining fluids, the formulation alters the physical properties such as the surface tension, surface elasticity, and bulk viscosity of the mucosal lining. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. The formulations may... |
| Breathing gas delivery method and apparatus | 20070044796 | 20070301 |
| An improved methodology and systems for delivery of breathing gas such as for the treatment of obstructive sleep apnea through application of alternating high and low level positive airway pressure within the airway of the patient with the high and low airway pressure being coordinated with the spontaneous respiration of the patient, and improved methods and apparatus for triggering and for leak management in such systems.
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| Method and apparatus for optimizing the continuous positive airway pressure for treating obstructive sleep apnea | 20070016093 | 20070118 |
| A breathing apparatus is provided for the treatment of obstructive sleep apnea that optimizes the positive pressure to the airway of a patient. The apparatus is configured to detect flow limitations in the patient airway from an analysis of inspiratory flow waveforms. The airway pressure setting is raised, lowered or maintained depending on whether a flow limitation has been detected and on the previous actions taken by the apparatus. The apparatus may include a blower, a flow sensor, a pressure sensor, a microprocessor, a pressure controller and a nasal fitting. The apparatus is configured to increase the airway pressure when a flow limitation is detected in the airway of the patient and to decrease the airway pressure when a flow limitation is not detected.
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| Sleep appliance | 20060289013 | 20061228 |
| A dental oral appliance for use with patients who suffer with sleep disorders, to reduce or eliminate snoring and to open the airway for a sleeping individual who suffers with obstructive sleep apnea. The appliance covers the inside (lingual) of the upper teeth and has an open palate. Retention for the appliance is provided by either clasps placed over the upper right and left molars and a retainer in the anterior area or by an occlusal coverge of the upper teeth. A raised incisor ramp that extends from the incisal tip (biting edge) of the incisors toward the lingual, or posterior raised ramps, separate the posterior teeth to reduce spasm on the temporalis muscle. A transverse, transpalatal ramp, which extends from the inside (lingual) of the... |
| Ventilator systems targeting specific populations | 20060249154 | 20061109 |
| A portable ventilator system is loaded with specialized software that addresses specific needs of a targeted patient population. Particularly contemplated target patient populations include patients with chronic obstructive pulmonary diseases (asthma, bronchitis, emphysema, etc.), obstructive sleep apnea, congestive heart failure, neuromuscular paralysis, a high risk of sudden cardiac arrest, and individuals vocationally likely to encounter nuclear, biological, or chemical hazards. Preferred systems include a radio frequency transmitter that sends data from the system to a distal service provider. Contemplated data that can be sent includes location information, diagnostic and intervention information. In another aspect systems can be is integrated with a defibrillator.
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| Treatment for sleep apnea | 20060252685 | 20061109 |
| The present invention relates to compositions and methods of alleviating a symptom of sleep apnea, snoring associated with and independent of sleep apnea, and/or sudden infant death syndrome by administering oxytocin. Specifically, the invention includes a method of administering oxytocin or a salt thereof to an animal in order to treat obstructive sleep apnea, snoring associated with and independent of sleep apnea, and sudden infant death syndrome.
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| Implant for tongue | 20060235264 | 20061019 |
| A method and apparatus for treating a condition of a patient's airway includes identifying a patient with obstructive sleep apnea and identifying a muscle of a tongue of the patient. A first brace is implanted within the tongue at a first implant location near the top of the tongue. A second brace is implanted within the tongue at a second implant location below the upper location. The first and second braces are connected to compress the muscle group.
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| Method of treating obstructive sleep apnea using electrical nerve stimulation | 20060224211 | 20061005 |
| A method for treating a medical condition, such as obstructive sleep apnea, includes the step of stimulating a nerve, particularly the hypoglossal nerve, using at least one of the following techniques: (a) continuous low-level electrical stimulation; (b) electrical stimulation synchronized with a physical process, such as inspiration, without feedback from the nerve being stimulated; and (c) intermittent electrical stimulation at controlled intervals based on the patient's metabolism.
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| Centralized hospital monitoring system for automatically detecting upper airway instability and for preventing and aborting adverse drug reactions | 20060195041 | 20060831 |
| A system and method for the automatic diagnosis of obstructive sleep apnea in a centralized hospital critical care monitoring system for the monitoring of a plurality of patients in at least one of a critical care, step down, and cardiac ward by telemetry. The system includes a central processor having a display, and a plurality of telemetry unit for mounting with patients, each of the telemetry units has a plurality of sensors for connection with each patient, the telemetry unit is capable of the transmission of multiple signals derived from the sensors to the central processor, in one preferred embodiment the method comprising steps of programming the system to analyze the signals and to automatically identify the presence and severity of obstructive sleep apnea and to... |
| Combination sleep apnea treatment | 20060185673 | 20060824 |
| A method for treating a patient diagnosed with obstructive sleep apnea includes identifying a patient as having sleep apnea susceptible to a first positive airway treatment which is at a first operating pressure level in excess of that which is otherwise tolerable to the patient. The patient is treated with an airway treatment selected to alter a portion of an airway tissue of the patient. The patient is then treated with a second positive airway pressure treatment at a second pressure level, which is below the pressure threshold.
... |
| Customizable facial seal for masks delivering breathing gases in positive pressure ventilation systems | 20060185675 | 20060824 |
| This device is a facial seal containing an internal bladder that is filled or pressurized with a quick set compound while on the face of the patient. The quick set compound conforms to the face of the wearer while in the seal itself, resulting in a better, substantially leakproof, fit. This is critical in applications where breathing gases are being supplied to the patient at greater than air pressure. One such application involves inflating the airway for the treatment of obstructive sleep apnea.
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| System and method for hyoidplasty | 20060150986 | 20060713 |
| Methods and devices are disclosed for manipulating the hyoid bone, such as to treat obstructive sleep apnea. A conformable implant is positioned adjacent a hyoid bone. The spatial orientation of the hyoid bone is manipulated, to affect the configuration of the airway. The implant restrains the hyoid bone in the manipulated configuration. The implant is positioned adjacent to pharyngeal structures to dilate the pharyngeal airway and/or to support the pharyngeal wall against collapse. The implant may be attached to the hyoid bone using a clamp delivery tool that is adapted to releasably engage the implant.
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| Nadph oxidase inhibition pharmacotherapies for obstructive sleep apnea syndrome and its associated morbidities | 20060154856 | 20060713 |
| The invention relates to compositions and methods for treating Obstructive Sleep Apnea (OSA). Specifically, the invention relates to the use of NADPH Oxigenase inhibitors in compositions and methods for treating OSA in a subject.
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| Flow diverter for controlling the pressure and flow rate in cpap device | 20060144402 | 20060706 |
| A flow diverter valve is used in controlling the pressure and/or flow rate of a breathable gas supplied to the airways of a patient by a breathable gas flow generator supply apparatus during, for example, ventilatory assistance treatments such as non-invasive positive pressure ventilation and nasal Continuous Positive Airway Pressure (CPAP) treatment of Obstructive Sleep Apnea. The flow diverter valve includes a vane and a housing. The housing has an inlet port, an outlet port, and an exhaust port. The exhaust port opens to atmosphere, and the inlet port is in fluid communication with the flow generator. The outlet port is in fluid communication with a patient mask via a conduit. The vane is configured with respect to the housing such that a blower associated with... |
| System and method for treating obstructive sleep apnea | 20060145878 | 20060706 |
| There is disclosed a system and method for treating obstructive sleep apnea by terminating an obstructive sleep apnea event before the cessation of breathing occurs. The system comprises one or more microphones capable of detecting breathing sounds within an airway of a person. The microphones generate signals representative of the breathing sounds and send the signals to a controller. The controller uses digital signal processing to identify at least one signal pattern that is associated with a breathing pattern of the person that occurs at the onset of an obstructive sleep apnea event. When the controller detects a signal pattern that indicates the onset of an obstructive apnea event, the controller sends an alarm signal to a stimulus generator. The stimulus generator creates a stimulus (an... |
| Device and method for treating obstructive sleep apnea | 20060142815 | 20060629 |
| A device and method are provided for treating obstructive respiratory events by electrically stimulating tissue associated with the phrenic nerve or diaphragm to elicit a respiratory response.
... |
| Treatment of obstructive sleep apnea | 20060130833 | 20060622 |
| Obstructive sleep apnea and snoring are treated by administering a sedative or hypnotic drug, including barbiturates and antihistamines.
... |
| Method and apparatus to detect and monitor the frequency of obstructive sleep apnea | 20060079802 | 20060413 |
| The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus includes an intracardiac impedance sensor to measure intracardiac impedance, a movement sensor to measure an amount of movement of a patient, and a controller operatively coupled to said intracardiac impedance sensor and said movement sensor, said controller adapted to receive at least one of an intracardiac impedance and the amount of movement of the patient and detect obstructive sleep apnea based upon said intracardiac impedance and said movement.
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| System and method for airway manipulation | 20060070626 | 20060406 |
| Methods and devices are disclosed for manipulating the airway, such as to treat obstructive sleep apnea. An implant is positioned within the body with respect to the airway. The spatial orientation of the airway is manipulated, directly or indirectly, to affect the configuration of the airway. In general, the implant is manipulated to displace the trachea in an inferior direction, resist superior displacement of the trachea and/or to alter the tracheal wall tension. The implant restrains the trachea in the manipulated configuration.
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