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Obstructive Sleep Apnea patents

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 System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue patent thumbnailSystem for stimulating a hypoglossal nerve for controlling the position of a patient's tongue
A system for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the hypoglossal nerve to stimulate at least one muscle of the tongue. The system may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle.
Imthera Medical, Inc.


 System and  treating obstructive sleep apnea and correcting malocclusion simultaneously patent thumbnailSystem and treating obstructive sleep apnea and correcting malocclusion simultaneously
A system and method for simultaneously (i) treating a patient's malocclusion by repositioning teeth from an initial tooth arrangement to a final tooth arrangement and (ii) treating obstructive sleep apnea (“osa”) by forcing the mandible forward comprises a plurality of (e.g., 10-30) sets of individual appliances. The appliances are configured to be placed successively on the patient's upper and lower dental arches and to incrementally reposition the teeth and forcing the jaw forward, during sleep.

 Obstructive sleep apnea and snoring prevention dental appliance patent thumbnailObstructive sleep apnea and snoring prevention dental appliance
Some embodiments of the present disclosure include a dental appliance for treating/preventing sleep apnea and snoring. The dental appliance may be a wedge-shaped device designed to be positioned between the lower and upper jaw, wherein the device is thicker within a front area of the mouth and thinner within a back area of the mouth.

 Method of stimulating a hypoglossal nerve for controlling the position of a patient's tongue patent thumbnailMethod of stimulating a hypoglossal nerve for controlling the position of a patient's tongue
A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle.

 Stimulation of a hypoglossal nerve for controlling the position of a patient's tongue patent thumbnailStimulation of a hypoglossal nerve for controlling the position of a patient's tongue
A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve, applying an electric signal through the electrode to the hypoglossal nerve to stimulate at least one muscle of the tongue at least until the number of obstructive sleep apnea occurrences are reduced from an initial level to a treatment level, and reducing the application of the electric signal while the number of obstructive sleep apnea occurrences remain generally at or below the treatment level.. .

 Negative pressure oral apparatus patent thumbnailNegative pressure oral apparatus
This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off.
Somnics, Inc.


 Obstructive sleep apnea treatment device patent thumbnailObstructive sleep apnea treatment device
17. .

 Discrimination of cheyne-stokes breathing patterns by use of oximetry signals patent thumbnailDiscrimination of cheyne-stokes breathing patterns by use of oximetry signals
Methods and apparatus provide cheyne-stokes respiration (“csr”) detection based on a blood gas measurements such as oximetry. In some embodiments, a duration, such as a mean duration of contiguous periods of changing saturation or re-saturation occurring in an epoch taken from a processed oximetry signal, is determined.
Resmed Limited


 Obstructive sleep apnea treatment devices, systems and methods patent thumbnailObstructive sleep apnea treatment devices, systems and methods
A method of treating a patient, comprising: sensing a biological parameter indicative of respiration; analyzing the biological parameter to identify a respiratory cycle; identifying an inspiratory phase of the respiratory cycle; and delivering stimulation to a hypoglossal nerve of the patient, wherein stimulation is delivered if a duration of the inspiratory phase of the respiratory cycle is greater than a predetermined portion of a duration of the entire respiratory cycle.. .
Cyberonics, Inc.


 Distinguishing between central and obstructive sleep apnea patent thumbnailDistinguishing between central and obstructive sleep apnea
Apparatuses and methods for detecting sleep apnea and classifying the events as obstructive sleep apnea (osa) and/or central sleep apnea (csa) are disclosed herein. The apparatuses can include respiratory treatment devices that have an auto adjusting algorithm that is able to classify a sleep apnea as csa or osa so that an appropriate pressure can be applied to the patient depending on the type of sleep apnea detected.
Fisher & Paykel Healthcare Limited


Devices and methods for sleep apnea treatment


Devices and methods for improving the coupling between the soft palate and the genioglossus. This may be accomplished, for example, but shortening or stiffening the palatoglossal arch.
Cyberonics, Inc.


Apparatus, systems, and methods for treating obstructive sleep apnea


Apparatus, systems, and methods are provided for treating obstructive sleep apnea. A unitary valve assembly removably located inside the exterior profile of a nasal pillow mask uses positive airway pressure from a low-flow hose to automatically create an on-demand therapeutic air splint in the pharynx.
Fresca Medical Inc.


Treatment of sleep apnea with a combination of a carbonic anhydrase inhibitor and an aldosterone antagonist


This invention relates generally to methods and pharmaceutical formulations useful in treating patients suffering from sleep apnea, including obstructive sleep apnea syndrome (osas). Treatment is effected by administering a carbonic anhydrase inhibitor to the patient in combination with an aldosterone antagonist.
Vivus, Inc.


Compositions and methods related to obstructive sleep apnea


The technology concerns methods and compositions for diagnosing obstructive sleep apnea, a common condition observed in children. In certain embodiments, there are methods and compositions relating to the use of novel biomarkers to diagnose obstructive sleep apnea..
The University Of Chicago


Devices for diagnosing sleep apnea or other conditions and related systems and methods


A system includes a sensor device having a body configured to be inserted into an airway of a patient and one or more sensors mounted in or on the body. The one or more sensors are configured to collect sensor data associated with the airway of the patient.

Device for the hindrance of snoring and obstructive sleep apnea


A head-wearable device is disclosed. The head-wearable device includes a headgear support structure, a band structure for securing the headgear support structure to the wearer's head, and a protrusion assembly affixed to the headgear superstructure for hindering the wearer's head from assuming a supine position during sleep.
Nitecap, Inc.


Tongue deformation implant


There is provided a method and apparatus for a tongue implant to induce deformation of the tongue made of nitinol in superelastic state at body temperature for the treatment of obstructive sleep apnea. In one embodiment the implant has a function of a v shaped spring, one leg helically inserted into the tongue, the other leg beneath the root of the tongue, to permanently compress the tongue.

Tissue crosslinking for treatment of snoring and obstructive sleep apnea


A method of treating snoring and/or osa in a subject in need of such treatment. The method includes crosslinking proteins of the subject's soft palate tissue or pharynx tissue.
Orthopeutcs. L.p.


Preparations for the treatment of sleep-related respiratory disorders


The present invention is directed to combinations of sedating antihistamines and at least one, and preferably two or more dietary supplements, which can be indole-based, such as tryptophan, 5-hydroxytryptophan, serotonin, n-acetyl-5-hydroxytryptamine and melatonin, and to their use for treating and thereby improving the health and quality of life of those suffering from sleep-related respiratory disorders, characterized by abnormal breathing during sleep. These include snoring, sleep disordered breathing, sleep apneas, upper airway resistance syndrome, obstructive sleep apnea, central sleep apnea and obesity hypoventilation syndrome and associated ailments..
Requis Pharmaceuticals Inc.


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Methods and devices for soft palate tissue elevation procedures


A self-retaining suture having particular application for treating obstructive sleep apnea and use thereof. The suture includes rising an elongated suture body having a periphery and first and second tissue-penetrating ends each with a bi-curve needle, and a plurality of first retainers on a first segment and oriented to the first end, and a plurality of second retainers a second segment and oriented to the second end, and a retainer-free transition segment disposed between the pluralities of first and second retainers..
Ethicon, Inc.


Oral devices, kits and methods for reducing sleep apnea, snoring, and/or nasal drainage


Apparatus for reducing obstructive sleep apnea, snoring and/or nasal drainage. One apparatus includes an upper member fitting the interior and exterior surfaces of a user's upper dentition, and a lower member fitting similarly adjacent a user's lower dentition.
W. R. Wagner Family Limited Partnership


Implanted tongue pulling device, pull plate, pull line, retractor and method


An implanted tongue pulling device including a pull plate, a pull line, a retractor and a method thereof are provided. The tongue pulling device is implanted in the mandible and tongue of a human body, respectively, for tightening the tongue dorsum and/or the tongue base for treating obstructive sleep apnea/hypopnea syndrome (osahs).

Devices, the treatment of sleep apnea


A medical appliance for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient, the appliance comprising: a biasing member for inserting behind and exerting a force upon the patient's soft palate or tongue, wherein the biasing member is inserted in a reduced or minimized form and then expanded or firms once in place to exert the force. The appliance may be nasally inserted or be placed through the mouth.
Lumen Devices Llc


Screening devices and methods for obstructive sleep apnea therapy


Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position.
Cyberonics, Inc.


Method of deciding risk of obstructive sleep apnea syndrome, deciding sinking of hyoid bone, programs, x-ray diagnostic system, and making oral appliance


The method of includes detecting at least the hyoid bone, sella s, gonion go and menton me by lateral head and neck radiography of the subject; and deciding whether the center of the body or the whole of the body of the detected hyoid bone is included in an area above a perpendicular drawn toward the extended line of the segment s-go from me or not.. .

System and limiting flow and/or pressure compensation during limited flow respiratory therapy


The present disclosure pertains to a pressure support system (10) configured to deliver a pressurized flow of breathable gas to the airway of a subject (12). The system (10) is configured to treat obstructive sleep apnea, other sleep disordered breathing, and/or other respiratory issues with limited flow respiration therapy, and/or other therapies.
Koninklijke Philips N.v.


Respiratory patient interfaces


Various embodiments of respiratory patient interfaces that may be used to treat a variety of disorders involving upper airway obstruction, such as, without limitation, obstructive sleep apnea (osa), obstructive sleep hypopnea, and upper airway resistance syndrome (uars). A number of the embodiments employ a nasal pillow assembly including a frame that supports a nasal pillow sleeve and a clip that is slid over a flange of the fame to couple the nasal pillow sleeve to the frame..
Koninklijke Philips N.v.


"therapeutic use of peptide inhibitors of nadph oxidase; aerosolization as a delivery mechanism"


A method is provided for treatment of a condition mediated by nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by nox2.
University Of Pittsburgh-of The Commonwealth System Of Higher Education


System and sleep apnea assessment


A computer system and method for determining an appropriate risk group of having obstructive sleep apnea (osa) for an individual are disclosed. The system includes: an electronic data store storing a plurality of user profiles and a questionnaire; an input means for receiving one or more user inputs from a user related to the questionnaire; and an analytics module configured to determine if the user is obese or not based on the one or more user inputs, and further to determine the appropriate risk group of having osa for the user based on the one or more user inputs..

Methods and apnea therapy stimulation


Disclosed herein, among other things, are methods and apparatus related to apnea therapy. One aspect of the present subject matter provides a method for apnea directed therapy.

Discrimination of apnea type by medical device


Disclosed herein, among other things, are methods and apparatus related to identification of apnea type. One aspect of the present subject matter provides a method for real-time apnea discrimination.

Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues


Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis..
Cryosa, Llc


Intraoral managing snoring and obstructive sleep apnea


A removable, adjustable intraoral apparatus having an upper plate and a lower plate, which, upon insertion into a user's mouth, cause advancement of the lower jaw relative to the upper jaw. One of either the lower plate or the upper plate can include length-adjustable blocks on the occlusal (biting) side thereof for causing further advancement of the lower jaw.
Map Laboratory Llc


Micro-mechanical device and obstructive sleep apnea treatment


A method for removing a volume of tissue from a tongue in a patient to treat sleep apnea may involve cutting tissue from the tongue using a tissue cutting device having a shaft and at least one moveable cutting member attached to the shaft at a distal end of the tissue cutting device and moving the cut tissue through a channel of the shaft in a direction from the distal end of the tissue cutting device toward a proximal end of the device. A device for removing a volume of tissue from a tongue in a patient to treat sleep apnea may include a shaft, at least one moveable cutting member disposed at a distal end of a distal tip of the shaft, a handle coupled with a proximal portion of the shaft, and an actuator..
Microfabrica Inc.


Glp-1 receptor agonist compounds for obstructive sleep apnea


The disclosure provides, among other things, the use of glp-1 receptor agonist compounds to treat obstructive sleep apnea. The glp-1 receptor agonist compounds may be exendins, exendin analogs, glp-1 (7-37), glp-1 (7-37) analogs (e.g., glp-1 (7-36)-nh2) and the like.
Amylin Pharmaceuticals, Llc


Dental sleep appliance


A dental oral appliance for use with patients who suffer with sleep disorders, to reduce or eliminate snoring or obstructive sleep apnea and to open the airway for a sleeping patient. Retention for the appliance is provided by an occlusal coverge, or wire clasps, on the upper or lower teeth.

Treatment of obstructive sleep apnea syndrome with a combination of a carbonic anhydrase inhibitor and an additional active agent


This invention relates generally to methods and pharmaceutical formulations useful in treating patients suffering from obstructive sleep apnea syndrome (osas). Treatment of osas is effected by administering a carbonic anhydrase inhibitor to the patient in combination with at least one additional active agent.
Vivus, Inc.


Nasopharyngeal device for obstructive sleep apnea syndrome


The system and method for reducing or eliminating obstructive sleep apnea in patients with the use of a nasopharyngeal device. The nasopharyngeal device has at least one cup and a balloon-cuff located at opposing ends of a semi-rigid, solid-walled tube.

Systems and methods of detecting and treating obstructive sleep apnea


A method of providing a sleep apnea nerve stimulation therapy to a subject may include detecting a respiratory waveform of the subject with a sensor. The sensor may be configured for coupling to the subject.
Cyberonics, Inc.


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Intraoral functional device for relieving obstructive sleep apnea syndrom, snoring and/or other airway disorders


An intraoral device (1) includes upper cooperating elements (2) adapted to cooperate with the upper jaw (4) and lower cooperating elements (3) adapted to cooperate with the lower jaw (5); a bracket (19) fixed in the cooperating elements (2,3), the bracket (19) supports a target (18) aiming at inducing mandibular advancement and attracting the tip of the tongue; the target (18) being centered, in a transverse plane, with regard to the cooperating elements (2,3). The device (1) further includes stimulating elements (17) for stimulation of the tongue muscles, preferably the genioglossus, involving reflex exploration of the stimulating elements (17) by the tongue.

System and assessing treatment effects on obstructive sleep apnea


A system and method for assessing treatment effects on obstructive sleep apnea are provided. The apparatus includes a bio-signal measurement unit, a combined index calculation unit, and a treatment response assessment unit.
Seoul National University Bundang Hospital


Method of stimulating a hypoglossal nerve for controlling the position of a patient's tongue


A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle.
Imthera Medical, Inc.


Ultrasound localization of obstruction for obstructive sleep apnea


Techniques for ultrasound location of obstructions during osa include an ultrasound transducer array configured, upon receipt of a signal, to obtain first data that supports a plurality of ultrasound images representing a corresponding plurality of cross sections of an airway in a neck of a subject. Second data is received automatically on a processor, from an apnea event sensor set that is configured to collect automatically the second data sensitive to an apnea event in the subject.
University Of Maryland, Baltimore


Partially erodable systems for treatment of obstructive sleep apnea


A method of maintaining airway patency in an airway of a patient which includes the steps of implanting a device into tissue adjacent an airway, the device having a bioerodable material wound around a resiliently deformable body to temporarily maintain the deformable body in a stretched, deformed state, and permitting the bioerodable material of the device to bioerode to apply a force to maintain airway patency. The invention also provides devices for practicing the method..

Wireless closed-loop and system to detect and treat sleep apnea


A wireless implantable system is provided that is externally powered and comprises of a closed-loop feedback for treating both patients with obstructive and central sleep apnea. A method is provided for treating sleep apnea using an implantable device.
Pacesetter, Inc.


Formulations for alteration of biophysical properties of mucosal lining


Conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment, and methods of use, have been developed. One or more active agents, such as antivirals, antimicrobials, anti-inflammatories, proteins or peptides, may optionally be included with the formulation.
Pulmatrix, Inc.


Methods and compositions for treating sleep-related breathing disorders


Provided herein are methods of treating a sleep-related breathing disorder, such as obstructive sleep apnea, comprising the administration of o-desmethylvenlafaxine or duloxetine.. .
Sunovion Pharmaceuticals Inc.


Methods and kits for diagnosing obstructive sleep apnea


The presently-disclosed subject matter provides methods and kits for diagnosing obstructive sleep apnea (osa) in a subject, such as a human child, wherein a biological sample is provided from the subject and the amount of a urocortin iii peptide is determined from the sample. Further provided are methods for diagnosing osa in a subject wherein the amount of a urocortin iii peptide and one or more peptides selected from a uromodulin peptide, an orosomucoid 1 peptide, and a kallikrein 1 peptide are determined in a biological sample from a subject..
University Of Louisville Research Foundation, Inc.


Methods and apparatuses for performing remote titration of mandibular protrusion


Methods and apparatus for performing system validation and providing predictive criteria during remote titration of mandibular protrusion are disclosed herein. The effectiveness of oral appliance therapy can possibly be improved by screening obstructive sleep apnea subjects and prospectively identifying subjects suitable for oral appliance therapy.
Zst Holdings, Inc.


Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity


Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.. .
Auspex Pharmaceuticals, Inc.


Sleep apnea treatment


Apparatus and methods are described, including apparatus for treating a subject for obstructive sleep apnea (osa). The apparatus includes an implant, an imaging device, and a control unit.
Rainbow Medical Ltd.


Stimulation of a hypoglossal nerve for controlling the position of a patient's tongue


A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve, applying an electric signal through the electrode to the hypoglossal nerve to stimulate at least one muscle of the tongue at least until the number of obstructive sleep apnea occurrences are reduced from an initial level to a treatment level, and reducing the application of the electric signal while the number of obstructive sleep apnea occurrences remain generally at or below the treatment level.. .
Imthera Medical, Inc.


Device and correcting obstructive sleep apnea


An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone, where the ferric element is disposed to face along a treatment vector from the hyoid bone, and the treatment vector is oriented relative to a sagittal plane of a human. The orthotic obstructive sleep apnea treatment device further includes an external orthotic neck device having a contoured housing with a shape disposed to conform about a neck of the human subject, where the housing includes a force delivery element disposed at an exterior-front neck region of the human subject and is disposed to provide an attractive force to the ferric element along the treatment vector.
The Regents Of The University Of California


System and treating obstructive sleep apnea


One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source.
The Cleveland Clinic Foundation


Sleep apnea control device


Disclosed herein are various methods, systems, an apparatuses for determining appropriate situations to treat conditions such as sleep apnea. At appropriate times, treatment can be applied such as through electrical stimulation to a person (e.g., an electrical stimulation of a person's genioglossus muscle in response to detecting that the person is undergoing an obstructive sleep apnea precursor event).
Otologics, Llc


Compositions and methods for the treatment of neurological degenerative disorders and neurological diseases


The invention relates to the compounds of formula i or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i, and methods for the treatment of neurological degenerative disorders and neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.

Method and breathing assistance


Methods and system for treating obstructive sleep apnea and snoring are disclosed. The system generally comprises a mask for delivering pressurized air to patient's breathing orifice, a sensing mechanism for continuously assessing the state of patient's breathing and a pressure generator for generating the pressurized air in the mask.

Negative pressure on neck to treat obstructive sleep apnea


Systems and methods to treat obstructive sleep apnea draw soft tissue of the front of the neck of the subject, in particular at or near the oropharynx, into a cavity by applying negative pressure. The opening of the cavity is formed by a rim of a body that is configured to be engaged, externally, with a medial portion of the anterior side of the neck such that engagement between the rim and the neck forms a chamber that can be sealed from atmospheric pressure.
Koninklijke Philips N.v.


System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue


A system for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the hypoglossal nerve to stimulate at least one muscle of the tongue. The system may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle.
Imthera Medical, Inc.


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Obstructive sleep apnea treatment screening methods


Embodiments include a screening method for evaluating patient suitability for an implanted hypoglossal nerve stimulation (hgns) device. The screening method evaluates blood oxygen data relating to respiratory events, with the blood oxygen data providing mean blood oxygen desaturation values for comparison to severity thresholds to identify patients who are likely or unlikely to benefit from the implantation of the hgns device..
Cyberonics, Inc.


Airway implants and methods and devices for insertion and retrieval


Embodiments of the present invention relate to methods and devices for the treatment of airway obstruction, such as obstructive sleep apnea, and devices and methods that facilitate insertion and retrieval of the same. In one embodiment, disclosed is a tissue tensioner that includes an elongate flexible tether having a first end and a second end, a bone anchor configured to be connected to a patient's mandible, a tissue ingrowth implant configured to be implanted in a patient's tongue and connected to the second end of the tether, and an adjustment mechanism configured to be held by the bone anchor adjacent the patient's mandible and configured to receive the first end of the tether and configured to adjust tension in the flexible tether between the patient's mandible and tongue.
Koninklijke Philips N.v.


System and sleep disorder diagnosis and treatment


A system and method for sleep disorder diagnosis and treatment are disclosed. A particular embodiment is configured to: generate a first user interface for sleep disorder diagnosis, the first user interface including a plurality of questionnaires for prompting user input on a plurality of queries related to a user's sleep patterns, at least one questionnaire including queries related to the user's potential obstructive sleep apnea (osa) condition; generate a second user interface for sleep disorder treatment, the second user interface including a plurality of sleep disorder therapies to guide the user through a particular sleep disorder therapy automatically selected for the user based on the user's responses captured and processed by the first user interface, the second user interface being further configured to capture and retain a sleep log, the second user interface being further configured to generate a sleep efficiency assessment; and detect an osa condition in the user by use of a breathing disturbance metering system in wireless data communication with the first user interface and the second user interface..

Nostril inserts


Methods of use of a nasal insert to support smoking cessation, and methods of use of a nasal insert to reduce or eliminate snoring, and a method of use of a nasal insert to reduce the severity or to eliminate obstructive sleep apnea, and a method of use of a nasal insert to gain smoother, easier breathing through the nose. The nasal insert comprises a body having an inner surface which defines an air passageway surrounded by an outer surface of soft, flexible material.

Elastic tongue-dorsum retraction device, clamping pliers, installation pliers, line guide and implantation method


The present invention relates to an elastic tongue-dorsum refraction device for treating obstructive sleep apnea/hypopnea syndrome (osahs), clamping pliers, installation pliers, a line guide, and an implantation method. The elastic tongue-dorsum refraction device of the present invention includes a tongue dorsum connection mechanism, an elastic retractor and a tooth-side fastener.

Systems, methods and devices for diagnosing sleep apnea


Systems, methods and devices for diagnosing sleep apnea are provided herein. In one example, a device for detecting airway obstructions may be provided where the device may include a wearable hollow nasal tube to be positioned in an upper airway above a constriction point and an end imaging sensor coupled to the nasal tube to collect airway image data.

Tissue adjustment implant


Tissue adjustment implants useful for adjusting a position of tissue in a patient are described. In an embodiment, a tissue adjustment implant includes a main body having a series of outwardly-extending projections.

Sleep appliance with oxygen


A dental oral appliance to open the airway for a sleeping individual who suffers with snoring or obstructive sleep apnea comprising, a body, structure configured to removably affix the appliance to the upper or lower teeth, structure to prevent occlusion of the upper and lower teeth, a transpalatal member that extends from the lingual of the right molars to the lingual of the left molars, a posterior tongue restrainer attached to the transpalatal member, and one or more tubes extending from the anterior of the appliance to the posterior of the appliance for the delivery of oxygen into the oropharyngeal airway.. .

Simultaneous postive and negative airway pressure pump


A system and method of using both positive and negative airflow to create differential pressures in the oral and nasal cavities for support of the pharynx to treat obstructive sleep apnea.. .

Screening devices and methods for obstructive sleep apnea therapy


Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position.
Cyberonics, Inc.


System and hyoidplasty


Methods and devices are disclosed for manipulating the hyoid bone, such as to treat obstructive sleep apnea. A conformable implant is positioned adjacent a hyoid bone.
Koninklijke Philips N.v.


Apnea treatment


A closure for use during positive airway pressure treatment of obstructive sleep apnea for controlling air leakage through the lips and mouth of a person. The closure includes a first member formed of an air-sealing layer for extending over the lips of and to an adjacent region on the skin of the person.

Incremental and/or successive adjustable mandibular advancement device for preventing and treatment of snoring and obstructive sleep apnea


The current invention relates to an adjustable mandibular advancement device with a unique combination of resilient hinging and adjustability to prevent or reduce snoring and/or obstructive sleep apnea syndrome. The adjustability is described by means of two concepts of adjustability for the relative enlargement or diminution of the members of the device, incremental and successive advancement mechanisms, in either combination or separately.

Incremental and/or successive adjustable mandibular advancement device for preventing and treatment of snoring and obstructive sleep apnea


The current invention relates to an adjustable mandibular advancement device with a unique combination of resilient hinging, dentition engagement and adjustability, to prevent or reduce snoring and/or obstructive sleep apnea syndrome. The adjustability is described by means of two concepts of adjustability for the relative enlargement or diminution of the members of the device, incremental and successive advancement mechanisms, in either combination or separately.

System and anticipating the onset of an obstructive sleep apnea event


Systems and methods for detecting a general breathing event and for anticipating an onset of an obstructive sleep apnea (osa) event. The method for detecting a general breathing event includes receiving a plurality of signals from at least one microphone.

Devices for diagnosing sleep apnea or other conditions and related systems and methods


A system includes a sensor device having a body configured to be inserted into an airway of a patient and one or more sensors mounted in or on the body. The one or more sensors are configured to collect sensor data associated with the airway of the patient.

System and methods for estimating respiratory airflow


A system and methods for screening patients suspected of obstructive sleep apnea. The system includes a sound detection device configured for detecting tracheal respiratory sound signals of a patient and a sao2 detection device for detecting sao2 signals of the patient.

Apparatus and treating obstructive sleep apnea


The present invention describes an apparatus, a systems and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue an electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position..

Magnetic implants and methods for treating an oropharyngeal condition


Magnetic devices and implantation methods are provided for use in the treatment of obstructive sleep apnea. The devices include a sheet-like element having ferromagnetic qualities.

Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity


Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.. .

System and characterizing an upper airway using speech characteristics


The present invention relates to systems and methods for characterizing at least one anatomical parameter of an upper airway of a patient by analysing spectral properties of an utterance, comprising: a mechanical coupler comprising means for restricting the jaw position of the patient; means for recording an utterance; and processing means for determining at least one anatomical parameter of the upper airway from the recorded utterance and comparing the recorded utterance to a threshold value. In addition the present invention relates to the use of the above mentioned systems as a diagnostics tool for assessing obstructive sleep apnea..

Devices, kits, and methods for the treatment of obstructive sleep apnea


Devices, kits, and methods useful in the treatment of obstructive sleep apnea (osa) are described. Example devices include a jig, a first needle, a second needle, and a third needle.

Modular tissue securement systems


A system and method are disclosed for the securement of tissue and in particular for placement of a tongue base suspension fiber for the treatment of obstructive sleep apnea. The system incorporates disposable connectors with releasable needles to facilitate the placement of fibers with minimal increase in suture site dilation or trauma..

Wearable positive airway pressure (pap) with primary and bolus airflow


This invention can be embodied as a wearable self-contained device that provides energy-efficient positive airway pressure (pap) to treat obstructive sleep apnea (osa). This device includes a primary airflow member and a bolus airflow member which operate together in a coordinated manner to provide just the right amount of pressure that is needed at any given time in order to keep the person's airway open in the most energy-efficient manner.

Partially erodable systems for treatment of obstructive sleep apnea


The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material.

Method and device for treating obstructive sleep apnea


Methods and devices comprised of a collapsible insert member and shaping member for treating obstructive sleep apnea are described. The insert member is placed in the tongue or other tissue forming the airway of the patient and has a lumen to accommodate the shaping member.

Auto-feedback valve for a sleep apnea device


A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator.

Auto-feedback valve for a sleep apnea device


A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator.

Methods for treating obstructive sleep apnea


The present invention relates to methods for treating obstructive sleep apnea (osa), alleviating a negative osa symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments..

Method of stimulating a hypoglossal nerve for controlling the position of a patient's tongue


A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle.

Obstructive sleep apnea treatment devices, systems and methods


A method of treating a patient, comprising: sensing a biological parameter indicative of respiration; analyzing the biological parameter to identify a respiratory cycle; identifying an inspiratory phase of the respiratory cycle; and delivering stimulation to a hypoglossal nerve of the patient, wherein stimulation is delivered if a duration of the inspiratory phase of the respiratory cycle is greater than a predetermined portion of a duration of the entire respiratory cycle.. .

System and detecting sleep disorders


An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity.

Device for the hindrance of snoring and obstructive sleep apnea


Snoring and obstructive sleep apnea are mitigated or controlled by restricting head movement during sleep. A headgear is disclosed with extensions at the rear of the headgear which impedes or blocks sleeping with the head in the supine position.

Screening devices and methods for obstructive sleep apnea therapy


Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position.

Breathing disorder identification, characterization and diagnosis methods, devices and systems


Disclosed herein are breathing disorder identification, characterization and diagnosis methods, devices and systems. In general the disclosed methods, devices and systems may rely on the characterization of breath sound amplitudes, periodic breath sounds and/or aperiodic breath sounds to characterize a breathing disorder as obstructive (e.g.

Device and predicting and preventing obstructive sleep apnea (osa) episodes


A wireless sleep apnea treatment system comprises a garment having at least one ecg monitor, a wireless signal acquisition board in communication with the ecg monitor and the computer and providing the electrical reading from the ecg monitor to the computer, and a patient stimulator controlled by the computer through the wireless signal acquisition board.. .

Method and improved flow limitation detection of obstructive sleep apnea


In a respiratory apparatus for treatment of sleep apnea and other disorders associated with an obstruction of a patient's airway and which uses an airflow signal, an obstruction index is generated which detects the flattening of the inspiratory portion of the airflow. The flattening index serves as an obstruction index used to differentiate normal and obstructed breathing.

Acoustic system and methodology for identifying the risk of obstructive sleep apnea during wakefulness


Disclosed are a system and methods for screening a patient for obstructive sleep apnea using features of tracheal breath sounds obtained from the patient during wakefulness.. .

Treatment of obesity


The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the il-6 receptor and signals via interaction with a gp130/lif receptor heterodimer.



Obstructive Sleep Apnea topics:
  • Sleep Apnea
  • Obstructive Sleep Apnea
  • Epinephrine
  • Hypoglossal Nerve
  • Extensions
  • Electrical Signal
  • Transducer
  • Rheumatoid Arthritis
  • Osteoarthritis
  • Vasoconstriction
  • Pheochromocytoma
  • Cardiac Hypertrophy
  • Cardiac Arrhythmia
  • Norepinephrine
  • C Syndrome


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