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|| List of recent Nucleotide-related patents
|Gene combinations for producing punicic acid in transgenic plants|
Transgenic plants with enhanced punicic acid accumulation result from over-expression of pgfadx and pgfad2, and optionally, one or more of pgdgat1, pgdgat2, and pgpdat1. The invention also relates to novel isolated punica granatum diacylglycerol acyltransferases: type 1 (pgdgat1), type 2 (pgdgat2) and phospholipid:diacylglycerol acyltransferases (pgpdat1); polynucleotide sequences encoding the dgats and pdat enzymes; polynucleotide constructs, vectors and host cells incorporating the polynucleotide sequences; and methods of producing and using same..
|Compositions having dicamba decarboxylase activity and methods of use|
Compositions and methods comprising polynucleotides and polypeptides having dicamba decarboxylase activity are provided. Further provided are nucleic acid constructs, host cells, plants, plant cells, explants, seeds and grain having the dicamba decarboxylase sequences.
|Polypeptides having xylanase activity and polynucleotides encoding same|
Provided are isolated polypeptides having xylanase activity, catalytic domains and cellulose binding domains, and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains..
|Enhancing cell wall properties in plants or trees|
The present invention relates to a method for enhancing cell wall properties in plants. The method comprises introducing into the plant, at least one nucleotide construct comprising a nucleic acid molecule operatively linked to a regulatory region active in the plant, wherein said nucleic acid molecule encodes a polypeptide with galactinol synthase (gols)-like activity and growing the plant under conditions that permit the expression of the nucleic acid, thereby enhancing the cell wall property of the plant..
|Modulating beta-damascenone in plants|
A mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a neoxanthin synthase and having at least 60% sequence identity to seq id no:1 or seq id no. 6; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide having at least 66% sequence identity to seq id no:2 or at least 60% sequence identity to seq id no.
|Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics|
Provided are isolated polynucleotides at least 80% identical to seq id nos: 1-479, 813-5173, 8511, 8513, 8515, 8517, 8519, 8521, 8523, 9096-9141 and 9142; and isolated polypeptides at least 80% homologous to an amino acid sequence selected from the group consisting of seq id nos: 624, 480-623, 625-812, 5174-7015, 7017-7021, 7024, 7026-8510, 8512, 8514, 8516, 8518, 8520, 8522, 8524, 9143-9177, such as the polypeptides set forth in seq id no:480-812, 5174-8510, 8512, 8514, 8516, 8518, 8520, 8522, 8524, and 9143-9177, nucleic acid constructs comprising same, transgenic cells and plants expressing same and methods of using same for increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, nitrogen use efficiency, and/or abiotic stress tolerance of a plant.. .
|Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants|
Methods and materials for modulating low-nitrogen tolerance levels in plants are disclosed. For example, nucleic acids encoding low nitrogen tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells.
The present disclosure provides methods and compositions relating to a polynucleotide comprising a dsrna region that is complementary to a particular region of the ns1 gene segment in the influenza virus genome that targets a sequence comprising two overlapping reading frames, one encoding ns1 and the second encoding the nep polypeptide. Thus, the polynucleotide of the invention is able to target two message rnas and is effective at inhibiting the replication of influenza virus in a cell..
|Production of transgenic avians using improved retroviral vectors|
A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.. .
The present invention relates to a process for preparing a short oligonucleotide comprising the steps of: (i) preparing a crude mixture comprising the oligonucleotide (ii) subjecting the mixture formed in step (i) to a desalting step; wherein the process does not comprise a chromatographic purification step.. .
A novel class of pharmaceuticals which comprises a locked nucleic acid (lna) which can be used in antisense therapy. These novel oligonucleotides have improved antisense properties.
|Method for detecting and quantifying wheat endogenous gene|
Provided is a method of detecting or quantifying a wheat species-specific dna in a test sample by polymerase chain reaction. The method comprises a step of amplifying a nucleic acid molecule having at partial sequence of a nucleotide sequence identified as seq id no: 1 using a nucleic acid molecule in the test sample or a nucleic acid molecule extracted from the test sample as the template and using a primer pair capable of amplifying the partial sequence and a step of detecting or quantifying the amplified nucleic acid molecule..
|Treatment of autoimmune diseases|
Compositions can be used to stimulate growth of a hair shaft from a hair follicle. These compositions can include methylated polynucleotides useful in treatment of autoimmune diseases or conditions, including those, such as alopecia areata, that result in hair loss..
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids..
|Modified rnai agents|
One aspect of the present invention relates to double-stranded rnai (dsrna) duplex agent capable of inhibiting the expression of a target gene. The dsrna duplex comprises one or more motifs of three identical modifications on three consecutive nucleotides in one or both strand, particularly at or near the cleavage site of the strand.
|Exon skipping therapy for dystrophic epidermolysis bullosa|
The present invention also relates to an antisense oligonucleotide complementary to a nucleic acid sequence of col7a1 gene that is necessary for correct splicing of one or more exons which encode amino acid sequence of type vii collagen implicated in dysfunction of a mutated type vii collagen wherein said exons are selected from the group consisting of exon 73, 74 or 80 of the col7a1 gene. The present invention also relates to a method for the treatment of a patient suffering from dystrophic epidermolysis bullosa caused by a dysfunction of a mutated type vii collagen, comprising the step of administering to said patient a least one antisense oligonucleotide according to the invention..
|Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene|
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an antiviral gene, in particular, by targeting natural antisense polynucleotides of an antiviral gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of antiviral genes..
|Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip|
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of ‘c terminus of hsp70-interacting protein’ (chip), in particular, by targeting natural antisense polynucleotides of ‘c terminus of hsp70-interacting protein’ (chip). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of chip..
The invention provides methods of providing a prognosis of asthma severity in children and young adults. More specifically, the invention relates to novel single nucleotide polymorphisms (snps), and the cumulative genetic association of these and other snps in various genes, with the prognosis of asthma severity.
|Classification and actionability indices for lung cancer|
The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant.
This invention is directed in part to methods, assays and/or kits for identifying an individual who has an autoimmune disease (such as rheumatoid arthritis), or who has an altered risk for having or developing the autoimmune disease. The methods in one aspect comprise determining the presence or absence of a nucleic acid variant within the somatostatin receptor type 2 (sstr2) gene in the individual's nucleic acids, wherein the presence of the nucleic acid variant is correlated with having the autoimmune disease or the altered risk.
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