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Nucleotide patents



      

This page is updated frequently with new Nucleotide-related patent applications.




Date/App# patent app List of recent Nucleotide-related patents
02/04/16
20160036061 
 Tethering of cofactors on graphene-like materials patent thumbnailnew patent Tethering of cofactors on graphene-like materials
A family of customizable tethering molecules for tethering cofactors such as, but not necessarily limited to, nicotinamine adenine dinucleotide (nad+/nadh, nad(p)+/nad(p)h) to substrates or structures formed from or including graphene-like materials is described. The tethered cofactor can then be used, for example, as biosensors employed for clinical diagnostic, food industry, medical drug development and environmental and military applications, as well as in reagentless biofuel cells for power generation..
Stc.unm


02/04/16
20160034636 
 Oligonucleotide probes for specific identification of noroviruses and other pathogens patent thumbnailnew patent Oligonucleotide probes for specific identification of noroviruses and other pathogens
Embodiments of the present disclosure relate to the identification of norovirus genotypes using type specific probes. Other embodiments of the present disclosure relate to the identification of distinct types of organisms using type specific probes..
The United States Of America, As Represented By The Secretary Of Agriculture


02/04/16
20160033512 
 Diagnosis of carcinomas patent thumbnailnew patent Diagnosis of carcinomas
The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of he4a polypeptides, including he4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding he4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a he4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an he4a nucleotide sequence, as well as other related advantages..
Pacific Northwest Research Institute


02/04/16
20160033495 
 Detection of non-nucleic acid analytes using strand displacement exchange reactions patent thumbnailnew patent Detection of non-nucleic acid analytes using strand displacement exchange reactions
The present invention relates to an analyte detection system for detecting analytes different from dna and rna. The system comprises a set of oligonucleotides which may hybridize to each other in specific ways and is able to generate a signal based on the specific hybridization events.
Unisense Diagnostics Aps


02/04/16
20160032410 
 Detection and use of antiviral resistance mutations patent thumbnailnew patent Detection and use of antiviral resistance mutations
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis b virus (hbv) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies.

02/04/16
20160032408 
 Polynucleotide primers for detecting pik3ca mutations patent thumbnailnew patent Polynucleotide primers for detecting pik3ca mutations
A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: seq. Id nos.
Qiagen Manchester Limited


02/04/16
20160032405 
 Method for identifying or detecting genomic rearrangements in a biological sample patent thumbnailnew patent Method for identifying or detecting genomic rearrangements in a biological sample
A method for detection, visualization and/or comparison of polynucleotide sequences of interest using specially designed sets of long and short probes that enhance resolution and simplify visualization and detection. Probe compositions useful for practicing this method and procedures for identifying useful probes and probe combinations.
Genomic Vision


02/04/16
20160032393 
 Methods and kits for predicting prognosis of multiple sclerosis patent thumbnailnew patent Methods and kits for predicting prognosis of multiple sclerosis
Provided are methods and kits for predicting the prognosis of a subject diagnosed with multiple sclerosis by determining the expression level of polynucleotides which are differentially expressed between subjects diagnosed with multiple sclerosis and having good or poor clinical outcome. Also provided are methods and kits for selecting a treatment regimen of a subject diagnosed with multiple sclerosis..
Tel Hashomer Medical Research Infrastructure And Services Ltd.


02/04/16
20160032389 
 Method, kits, and reaction mixtures for high resolution melt genotyping patent thumbnailnew patent Method, kits, and reaction mixtures for high resolution melt genotyping
Various methods are described that provide for high resolution melt (hrm) genotyping. Some embodiments comprise providing a locus specific primer, and two allele specific primers each comprising at least one single nucleotide polymorphism (snp) allele-hybridizable sequence, wherein at least one of the allele specific primers also comprises at least one nucleotide alteration.
Life Technologies Corporation


02/04/16
20160032386 
 Genetic markers for osteoarthritis patent thumbnailnew patent Genetic markers for osteoarthritis
A method for predicting the severity or progression of oa in a human subject, comprising: determining the identity of at least one allele at each of at least 4 positions of single nucleotide polymorphism (snps) selected from the group consisting of: rs2206593, rs10465850, rs780094, rs1374281, rs1143634, rs2073508, rs2243250, rs4720262, rs917760, rs7838918, rs12009, rs730720, rs874692, rs893953, rs1799750, rs10845493, rs11054704, rs7986347, rs1802536, rs10519263, rs7342880, rs16947882 and rs10413815, and one or more snps in linkage disequilibrium at a level of at least r2≧0.8 therewith, as well as products, in particular systems and kits for use in such a method.. .
Progenika Biopharma S.a.


02/04/16
20160032385 
new patent

Method for detecting cystic fibrosis


The present invention relates to methods for simultaneously determining the presence or absence of mutations, deletions, duplications and single nucleotide polymorphisms in a cystic fibrosis transmembrane regulator (cftr) nucleic acid. Oligo nucleotide primers and kits used to amplify regions of a cftr nucleic acid for high throughput, massively parallel sequencing and methods of determining an individual's cystic fibrosis status are also disclosed..
Quest Diagnostics Investments Incorporated


02/04/16
20160032379 
new patent

Enzyme-linked nucleotides


Presented herein are polymerase-linked nucleotides for improved distinguishing nucleotide sequences for different nucleic acid molecules. Also presented are methods and systems using the polymerase-linked nucleotides for improved distinguishing nucleotide sequences for different nucleic acid molecules..
Illumina, Inc.


02/04/16
20160032378 
new patent

Modified nucleotides


The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-oh blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —o—z wherein z is any of —c(r′)2-o—r″, —c(r′)2-n(r″)2, —c(r′)2-n(h)r″, —c(r′)2-s—r″ and —c(r′)2-f, wherein each r″ is or is part of a removable protecting group; each r′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (r′)2 represents an alkylidene group of formula ═c(r′″)2 wherein each r′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each r″ is exchanged for h or, where z is —c(r′)2-f, the f is exchanged for oh, sh or nh2, preferably oh, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′oh; with the proviso that where z is —c(r′)2-s—r″, both r′ groups are not h.. .
Illumina Cambridge Limited


02/04/16
20160032377 
new patent

Modified polymerases for improved incorporation of nucleotide analogues


Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same.. .
Illumina, Inc.


02/04/16
20160032376 
new patent

Nucleotide analogs for sequencing


Provided herein is technology relating to sequencing nucleic acids, but not exclusively, to compositions, methods, systems, and kits related to nucleotides comprising an electrochemically detectable moiety and one or more photolabile synthesis-inhibiting moieties.. .
Ibis Biosciences, Inc.


02/04/16
20160032375 
new patent

Nucleic acid amplification


In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for nucleic acid amplification. In some embodiments, methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions.
Life Technologies Corporation


02/04/16
20160032357 
new patent

Method for relative quantification of changes in dna methylation, using combined nuclease, ligation, and polymerase reactions


The present invention is directed to methods for identifying the presence of one or more methylated or unmethylated target nucleotide sequences in a sample that involve a nuclease-ligation reaction. In some embodiments, the ligation products formed in the nuclease-ligation process of the present invention are subsequently amplified using a polymerase chain reaction.
Cornell University


02/04/16
20160032349 
new patent

Mitrecin a polypeptide with antimicrobial activity


The present invention provides a mitrecin a polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a mitrecin a polypeptide.
The Mitre Corporation


02/04/16
20160032336 
new patent

Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.


02/04/16
20160032328 
new patent

Methods and compositions for enhanced production of fatty aldehydes and fatty alcohols


The invention relates to the use of entd polypeptides, polynucleotides encoding the same, and homologues thereof to enhance the production of fatty aldehydes and fatty alcohols in a host cell.. .
Reg Life Sciences, Llc


02/04/16
20160032325 
new patent

Modified microorganisms and methods of making butadiene using same


The present disclosure generally relates to microorganisms that comprise one or more polynucleotides coding for enzymes in one or more pathways that catalyze a conversion of a fermentable carbon source to butadiene. Also provided are methods of using the microorganisms in industrial processes including, for use in the production of butadiene and products derived therefrom..
Braskem S.a.


02/04/16
20160032319 
new patent

Vectors comprising stuffer/filler polynucleotide sequences and methods of use


Recombinant viral vectors such as aav vectors designed with expression cassettes that approach the natural packaging capacity of the virus, such as aav are provided. The recombinant viral vectors reduce residual plasmid dna impurities..
The Children's Hospital Of Philadelphia


02/04/16
20160032316 
new patent

Purification and purity assessment of rna molecules synthesized with modified nucleosides


This invention provides purified preparations of an rna, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside, and methods of assessing purity of purified preparations of an rna, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside.. .
The Trustees Of The University Of Pennsylvania


02/04/16
20160032314 
new patent

Controlling fungal pathogens by disabling their small rna pathways using rnai-based strategy


The present invention relates to pathogen-resistant plants. In one aspect, plants comprising a heterologous expression cassette are provided, wherein the expression cassette comprises a polynucleotide that inhibits expression of a fungal pathogen dicer-like (dcl) gene and wherein the plant has increased resistance to a fungal pathogen compared to a control plant lacking the expression cassette.
The Regents Of The University Of California


02/04/16
20160032301 
new patent

Guard cell expression cassettes compositions and methods of use thereof


The invention is directed to artificial transcription regulating polynucleotides that confer guard cell regulated expression and methods of use thereof. The present invention further provides methods of using the transcription regulating polynucleotides and plants and plant parts thereof comprising the transcription regulating polynucleotides.
Syngenta Participations Ag


02/04/16
20160032296 
new patent

Polynucleotide sequences from rhodosporidium and rhodotorula and use thereof


The present invention relates to the application of isolated promoters and synthetic constructs for efficient production of genetically modified cells in a species selected from the pucciniomycotina and ustilaginomycotina subphyla, in particular, species selected from the rhodosporidium, rhodotourla, sporobolomyces or pseudozyma genus.. .
Temasek Life Sciences Laboratory Limited


02/04/16
20160032295 
new patent

Methods, compositions and kits for a one-step dna cloning system


Methods and kits for joining three or more polynucleotides to form a product polynucleotide are provided. Such a method includes forming a reaction mixture comprising (i) a vector fragment whose ends have four base overhangs resulting from cleavage of a vector with a first type iis enzyme, (ii) a first insert nucleic acid with a four base overhang at one end resulting from cleavage by the first type iis enzyme and a three base overhang at the other end resulting from cleavage by the second type iis enzyme; and (iii) a second insert nucleic acid with a four base overhang at one end resulting from cleavage by the first type iis enzyme and a three base overhang at the other end resulting from cleavage by the second type iis enzyme, and (iv) a ligase.
Dna 2.0, Inc.


02/04/16
20160032292 
new patent

Aptamer-guided gene targeting


Compositions and methods for modifying genetic material are provided. One embodiment provides aptamers capable of binding to a site-specific dna binding moiety to facilitate the exchange of homologous genetic information between a donor molecule and the desired target locus (aptamer-guided gene targeting or agt).
Georgia Tech Research Corporation


02/04/16
20160032290 
new patent

Pharmaceutical composition comprising nanog shrna, and using nanog shrna to treat cancer


The present description relates to an inhibitory rna molecule, comprising an oligonucleotide that selectively knocks down expression a nanog pseudogene expressed in many human cancers, a replicating viral vector capable of encoding such inhibitory rna molecule, pharmaceutical compositions comprising said vector, and methods of treating cancer by administration of said pharmaceutical composition.. .
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services


02/04/16
20160032289 
new patent

Oral delivery of therapeutically effective lna oligonucleotides


The invention provides for lna oligomers, for the treatment of a metabolic or liver disorder, wherein the lna oligomer is administered orally in a unit dose of less than 50 mgs/kg, wherein the lna oligomer is administered in the presence of a penetration (permeation) enhancer.. .
Roche Innovation Center Copenhagen A/s


02/04/16
20160032288 
new patent

Rna sequence-specific mediators of rna interference


The present invention relates to a drosophila in vitro system which was used to demonstrate that dsrna is processed to rna segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to drosophila extracts, they mediate rna interference in the absence of long dsrna.
University Of Massachusetts


02/04/16
20160032285 
new patent

Compositions and methods for modulating tau expression


Disclosed are methods for modulating splicing of tau mrna in an animal with tau antisense compounds. Also disclosed herein are methods for reducing expression of tau mrna and protein in an animal with tau antisense compounds.
Isis Pharmaceuticals, Inc.


02/04/16
20160032273 
new patent

Characterization of mrna molecules


The present invention describes methods for the characterization of mrna molecules during mrna production. Characterizing mrna includes processes such as oligonucleotide mapping, reverse transcriptase sequencing, charge distribution analysis, and detection of rna impurities.
Moderna Therapeutics, Inc.


02/04/16
20160032259 
new patent

Glycosylated vegf decoy receptor fusion protein


The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding vegf polypeptide and placenta growth factor (pigf) polypeptide comprising a nucleotide sequence encoding a vegfr1 component.. .
Korea Advanced Institute Of Science And Technology (kaist)


02/04/16
20160032244 
new patent

Method of inducing cellular differentiation using the notch3 receptor intracellular domain


The present invention relates to the intracellular domain of notch3 that can activate signaling and initiate transcription, thereby initiating cellular differentiation in general, and neuronal differentiation in particular. The present invention includes the use of polynucleotide sequences that code, entirely or partially, for the intracellular domain of notch3, for the purpose of inducing cellular differentiation.

02/04/16
20160032019 
new patent

Antibody constructs for cdh19 and cd3


The present invention provides to a bispecific antibody construct comprising a first human binding domain which binds to human cdh19 on the surface of a target cell and a second binding domain which binds to human cd3 on the surface of a t cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector.
Amgen Research (munich) Gmbh


02/04/16
20160032014 
new patent

Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9


The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inhibiting pcsk9 binding to ldlr and having increased ph sensitivity, improved binding affinity and/or increased in vivos half life. In embodiments, the antigen binding proteins specifically bind pcsk9 and have increased ph sensitivity, improved binding affinity and/or increased in vivos half life.
Amgen Inc.


02/04/16
20160031953 
new patent

Recombinantly expressed plasmodium celtos antigen and methods of use thereof


A synthetic nucleotide, which transcribes as the cell-traversal protein for ookinetes and sporozoites (celtos) antigen of malaria plasmodium, and methods of use thereof.. .

02/04/16
20160031928 
new patent

Ribonucleic acids with 4'-thio-modified nucleotides and related methods


Disclosed are messenger rna molecules and related compositions incorporating a 4′-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mrnas to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders. In certain embodiments, the 4′-thio modified mrna provides for enhanced stability and/or reduced immunogenicity in in vivo therapies..
Shire Human Genetic Therapies, Inc.


02/04/16
20160031918 
new patent

Photoresponsive nucleotide analogue having photocrosslinking ability


The present invention provides a new photoreactive compound which can be used in technologies for photoreactions of nucleic acid, and also provides a photoreactive crosslinking agent comprising the above photoreactive compound. A photoreactive compound represented by the following formula i can be used..
Japan Advanced Institute Of Science And Technology


02/04/16
20160030597 
new patent

S100b mini-promoters


Isolated polynucleotides comprising a s100b mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia


02/04/16
20160030569 
new patent

Low-glycerin formulations for hiv treatment and prevention


The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (nrtis), preferably [2-(6-amino-pur: in-9-yl)-1-methyl-ethoxymethy]-phosphonic acid (tenofivir, pmpa), or a physiologically functional derivative thereof, wherein the formulations contain a low level of glycerin. Human immunodeficiency vims (hiv) infection and related diseases are a major public health problem worldwide.
Conrad


02/04/16
20160030549 
new patent

Recombinant rsv with silent mutations, vaccines, and methods related thereto


In certain embodiments, the disclosure relates to the polynucleotide sequences of respiratory syncytial virus (rsv). In certain embodiments, the disclosure relates to isolated or recombinant nucleic acids and polypeptides comprising desirable nucleic acid sequences and mutations disclosed herein.
Children's Healthcare Of Atlanta, Inc.


02/04/16
20160030547 
new patent

Swine influenza viruses and constructs and uses thereof


Disclosed are compositions and methods comprising vectors and a reverse genetics competent unit comprising one or more recombinant influenza viruses. Recombinant influenza viruses comprising swine rna polymerase i promoter are disclosed.
University Of Maryland


02/04/16
20160030545 
new patent

Neisseria meningitidis antigens and compositions


The invention provides proteins from neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics..
Glaxosmithkline Biologicals Sa


02/04/16
20160030540 
new patent

Immunity inducing agent


Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of seq id nos: 2, 4, 8, 10 and 12; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a)..
Toray Industries, Inc.


02/04/16
20160030521 
new patent

Therapeutic agents comprising elastin-like peptides


The present invention provides therapeutic agents and compositions comprising elastin-like peptides (elps) and therapeutic proteins. In some embodiments, the therapeutic protein is a glp-1 receptor agonist, insulin, or factor vii/viia, including functional analogs.
Duke University


02/04/16
20160030511 
new patent

Neurotoxins exhibiting shortened biological activity


The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of biological effect in a subject, wherein the polypeptide comprises at least one degradation signal in the light chain as well as vectors and host cells comprising the polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides.
Merz Pharma Gmbh & Co. Kgaa


02/04/16
20160030332 
new patent

2-fluoro-modified rnas as immunostimulators


Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine non-linear single stranded rna at least 17 nucleotides long with a least 3 base pairings or a 5′ triphosphate, 2′ fluoro-modified double stranded rna at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject.
Duke University


02/04/16
20160029644 
new patent

Methods and compositions for weed control


The present invention provides novel compositions for use to enhance weed control. Specifically, the present invention provides for methods and compositions that modulate gene expression in johnsongrass.
Monsato Technology Llc


01/28/16
20160026757 

Method and calling single-nucleotide variations and other variations


Base calls for a target sequence may be identified relative to a reference sequence by using values from sequencing reads at locations satisfying a high-confidence condition to identify base calls at a given location not satisfying the high-confidence condition. The high-confidence condition may relate to the level of coverage by the sequencing reads at a location of the reference sequence.
Accura Science ,llc


01/28/16
20160025716 

Multisignal labeling reagents and processes and uses therefor


Provided are compounds comprising two dna supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a dna supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer.
Enzo Life Science, Inc., C/o Enzo Biochem, Inc.


01/28/16
20160025703 

Nucleic acid probes, their synthesis and use


The invention provides a method of probing for a nucleic acid comprising: contacting a nucleic acid solution with an oligonucleotide probe labelled with an electrochemically active marker, providing conditions at which the probe is able to at least partially hybridise with any complementary target sequence which may be present in the nucleic acid solution, selectively degrading either hybridised, partially hybridised or unhybridised nucleic acid probe, and electrochemically determining information relating to the electrochemically active marker. The invention further provides novel molecules with use in methods of the invention..
Atlas Genetics Limited


01/28/16
20160024600 

Coincidence reporter gene system


Disclosed is a nucleic acid comprising a nucleotide sequence encoding (i) two or more reporters comprising a first reporter and a second reporter that is different from the first reporter; and (ii) one or more ribosomal skip sequences, wherein a ribosomal skip sequence is positioned between the first and second reporters, wherein the first and second reporters are stoichiometrically co-expressed from the nucleotide sequence and the nucleic acid does not comprise a cytomegalovirus-immediate early (cmv-ie) promoter. Also disclosed are methods of screening test compounds for ability to modulate a biological activity of interest using the nucleic acid, as well as related recombinant expression vectors, host cells, and populations of cells..
The United States Of America, As Represented By The Secretary, Department Of Health And Human Ser


01/28/16
20160024599 

Compositions associated with soybean reproductive growth and methods of use


Molecular markers associated with soybean reproductive stage, methods of their use, and compositions having one or more marker loci are provided. Methods comprise detecting at least one marker locus, detecting a haplotype, and/or detecting a marker profile.
Pioneer Hi-bred International, Inc.


01/28/16
20160024590 

Falz for use as a target for therapies to treat cancer


The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of bptf. The disclosure also provides methods for determining whether a cancer in a subject is progressing or regressing based upon the change of expression levels of bptf between two time points.
Sutter West Bay Hospitals


01/28/16
20160024584 

Methods and systems for inferring bovine traits


Methods, compositions, and systems are provided for managing bovine subjects in order to maximize their individual potential performance and edible meat value, and to maximize profits obtained in marketing the bovine subjects. The methods and systems draw an inference of a trait of a bovine subject by determining the nucleotide occurrence of at least one bovine snp that is identified herein as being associated with the trait.
Branhaven Llc


01/28/16
20160024580 

Polymorphism of thrombospondin-1 as a biomarker for susceptabiltiy to dry eye


Embodiments of the invention relate to single nucleotide polymorphisms (snps) in thrombospondin 1 gene (thb-s1) that are herein linked to an increased risk for dry eye (also known as keratoconjunctivitis). The polymorphisms disclosed herein are directly useful for the diagnosis of an increased risk for dry eye, as well as for the determination of patient treatment pre- and post-surgery (e.g.
Trustees Of Boston University


01/28/16
20160024576 

Nucleic acid constructs and methods of use


The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired rois. Such validated rois and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like..
Prognosys Biosciences, Inc.


01/28/16
20160024574 

Dna sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators


This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached to a base thereof.. .
The Trustees Of Columbia University In The City Of New York


01/28/16
20160024573 

Photocleavable deoxynucleotides with high-resolution control of deprotection kinetics


Provided herein are new classes of photocleavable deoxynucleotides that allow for more precise control over deprotection kinetics compared to previously described compounds. The compounds further feature more favorable solubility properties.
Ibis Biosciences, Inc.


01/28/16
20160024571 

Scalable characterization of nucleic acids by parallel sequencing


A method for detecting the presence or absence of a target polynucleotide in a sample is described.. .
Affymetrix, Inc.


01/28/16
20160024566 

Compositions, methods, and kits for amplifying nucleic acids


The present teachings are directed to compositions, methods, and kits for amplifying target nucleic acids while reducing non-specific fluorescence and undesired amplification products, sometimes referred to as secondary amplification products or spurious side-products. The enzyme inhibitors disclosed herein comprise a nucleotide sequence and at least one quencher.
Applied Biosystems, Llc


01/28/16
20160024564 

Methods for non-invasive prenatal ploidy calling


Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal dna and maternal dna is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined.
Natera, Inc.


01/28/16
20160024562 

Polynucleotides for the amplification and detection of chlamydia trachomatis and neisseria gonorrhoeae


Polynucleotides useful for detecting chlamydia trachomatis and/or neisseria gonorrhoeae in a test sample, kits, a nucleic acid amplification method and detection method including the same.. .
Abbott Molecular Inc.


01/28/16
20160024546 

Methods for amplification of nucleic acids utilizing a circularized template prepared from a target nucleic acid


The present invention provides methods of amplifying a target nucleic acid utilizing a circularized template. Circularization may be achieved utilizing a bridging oligonucleotide or an inverter primer.

01/28/16
20160024520 

Cloning and use of the ms9 gene from maize


nucleotide sequences, amino acid sequences, and an associated promoter sequence are useful in methods of controlling male fertility in plants. Recombinant expression cassettes, vectors, plant cells, and plants comprise a disclosed nucleotide sequence and may encode a disclosed amino acid sequence.
E.i. Dupont De Nemours & Company


01/28/16
20160024518 

Production of small interfering rnas in planta


Disclosed herein are methods for reducing the expression of target nucleotide sequences using micrornas. Also disclosed herein are recombinant dna constructs comprising nucleotide sequences encoding such micrornas.
E.i. Dupont De Nemours & Company


01/28/16
20160024517 

Drought tolerant plants and related constructs and methods involving genes encoding self-incompatibility protein related polypeptides


Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes an sipr polypeptide..
Pioneer Hi-bred International Inc


01/28/16
20160024509 

Expression vector


An expression vector for expressing a target polypeptide in a prokaryotic cell is provided. The vector comprises a promoter operably linked to a polynucleotide encoding the target polypeptide operably linked to a eukaryotic secretion leader sequence, the eukaryotic secretion leader sequence encoding a signal peptide sequence selected from the group consisting of: a) mlkrsswlatlglltvasvstivya; b) mkkatfitcllavllvsnpiwna; c) mkvsaaalaviliatalcapasa; d) mkvstaflcllltvsafsaqvla; and e) mkclllalglalacaaqa.
Fujifilm Diosynth Biotechnologies Uk Limited


01/28/16
20160024508 

Method for identifying biologically active oligonucleotides capable of modulating the immune system


The present invention relates to methods of identifying oligonucleotides capable of modulating the immune system in a mammalian subject, comprising analysis of which tertiary structural type said oligonucleotide adopts, in phosphate-buffered saline solution. Further, the invention provides oligonucleotides identifiable by the methods of the invention and to their use in methods of treating diseases, such as inflammatory diseases, autoimmune diseases, infectious diseases, neurodegenerative diseases and cancer..
Index Pharmaceuticals Ab


01/28/16
20160024506 

Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a lipid transport and metabolism gene, in particular, by targeting natural antisense polynucleotides of a lipid transport and metabolism gene. The invention also relates to the identification of the antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of a lipid transport and metabolism genes..
Curna, Inc.


01/28/16
20160024505 

Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a lipid transport and metabolism gene, in particular, by targeting natural antisense polynucleotides of a lipid transport and metabolism gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of a lipid transport and metabolism genes..
Curna, Inc.


01/28/16
20160024501 

Methods for inducing cardiomyocyte proliferation


Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising mirna17-92 cluster oligonucleotides, e.g., mir-19a oligonucleotides, mir-19b oligonucleotides, or both mir-19a and mir-19b oligonucleotides.. .
Children's Medical Center Corporation


01/28/16
20160024500 

Oligomers


Molecules are provided for inducing or facilitating exon skipping in forming spliced mrna products from pre-mrna molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject.
Royal Holloway, University Of London


01/28/16
20160024495 

Lna antisense oligonucleotides for the modulation of myc expression


The disclosure relates to oligonucleotide compounds (oligomers) that target myc mrna in a cell, leading to reduced expression of myc. Reduction of myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer).
Dana-farber Cancer Institute, Inc.


01/28/16
20160024483 

Method of treating eye disease using glycosylated vegf decoy receptor fusion protein


The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding vegf polypeptide and placenta growth factor (pigf) polypeptide comprising a nucleotide sequence encoding a vegfr1 component.. .
Seoul National University Bundang Hospital


01/28/16
20160024215 

Llt-1 antibodies with new functional properties


The present invention relates to monoclonal antibodies that are capable of specifically binding to lectin-like transcript 1 (llt1), to polynucleotides encoding such antibodies, and to cells that express such antibodies. Antibodies of the invention have utility in the treatment of autoimmune diseases and cancer, in which llt1- and cd161-expressing cells play a role in disease pathogenesis..
Centre National De La Recherche Scientifique


01/28/16
20160024188 

Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof


Described are binding molecules such as human monoclonal antibodies that bind to influenza virus h5n1 and have neutralizing activity against influenza virus h5n1. Also described are polynucleotides encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies.
Crucell Holland B.v.


01/28/16
20160024181 

Long-lived polynucleotide molecules


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmrna molecules.. .
Moderna Therapeutics, Inc.


01/28/16
20160024177 

Novel epitope for switching to th1 cell and use thereof


The present invention relates to a novel epitope that converts t cell to type 1 helper t (th1) cell. Specifically, the present invention relates to an epitope constituting the 56th to 65th amino acids (seq id no.2) of extracellular domain (ecd) of activation-inducible tumor necrosis factor receptor (aitr), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting t cell to th1 cell and a method for converting t cell to th1 cell, a pharmaceutical composition comprising the antibody for preventing or treating cancer, a method for treating cancer using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody..

01/28/16
20160024174 

Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen


Provided are compositions and methods for prophylaxis and/or therapy of a variety of cancers which express a ny-eso-1 antigen. Included are recombinant t cell receptors (tcrs), polynucleotides encoding them, expression vectors that include the polynucleotides, and cells into which the polynucleotides have been introduced to produce modified cells, including cd4+ t cells, cd8+ t cells, natural killer t cells, γδ t cells, and progenitor cells, such as haematopoietic stem cells.
Health Research, Inc.


01/28/16
20160024173 

Non-hemolytic llo fusion proteins and methods of utilizing same


The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin o (llo) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest..
Advaxis, Inc.


01/28/16
20160024141 

Ion exchange purification of mrna


The current landscape for preparative chromatographic rna purification uses reversed phase hplc, but this technique presents many issues with process scale up and ion exchange for preparative purification has only been used for short rnas. The invention provides preparative purification of rna (e.g., mrna) using ion (e.g., anion) exchange chromatography that allows for separation of longer rnas up to 10,000 nucleotides in length via a scalable method.
Modema Therapeutics, Inc.


01/28/16
20160024140 

Ribonucleic acid purification


Disclosed herein are methods for purifying rna comprising poly a. Also disclosed herein are compositions such as surfaces and oligonucleotides for purifying rna comprising polya.
Moderna Therapeutics, Inc.


01/28/16
20160024138 

Method for deblocking of labeled oligonucleotides


The invention relates to a process for deblocking substantially a blocked, detectably labeled oligonucleotide by contacting the blocked detectably labeled oligonucleotide with an effective amount of a nucleophilic amino compound under conditions that result in substantial deblocking of the oligonucleotide, thereby giving the substantially deblocked oligonucleotide.. .
Life Technologies Corporation


01/28/16
20160024136 

Substituted nucleosides, nucleotides and analogs thereof


Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a hcv infection with one or more nucleotide analogs.. .
Alios Biopharma, Inc.






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