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Instituto Potosino De Investigación Cientifica Y Tecnológica A.c.
Candida albicans oligonucleotides, detection method, and kit thereof
Henry M. Jackson Foundation For Advancement Of Military Medicine
Prostate cancer gene expression profiles
|| List of recent Nucleotide-related patents
|Matrix stability compositions, test elements, test systems and methods of use thereof|
Reagent matrices and methods are disclosed for improving the stability of test elements with respect to degradation by humidity in the air. The reagent matrices and methods are based upon using an effective amount of a deliquescent material to decrease the sorption of water from the air by other components of a reagent matrix.
Roche Diabetes Care, Inc.
|Candida parapsilosis oligonucleotides, detection method, and kit thereof|
The invention discloses an in vitro method for the identification of candida parapsilosis, the sequences associated to said identification, as well as diagnosis kits for identifying candida parapsilosis.. .
Instituto Potosino De Investigación Cientifica Y Tecnológica A.c.
|Candida albicans oligonucleotides, detection method, and kit thereof|
The invention discloses an in vitro method for the identification of candida albicans, the sequences associated to said identification, as well as diagnosis kits for identifying candida albicans.. .
Instituto Potosino De Investigación Cientifica Y Tecnológica A.c.
|Prostate cancer gene expression profiles|
The present disclosure provides gene expression profiles that are associated with prostate cancer. The gene expression profiles can be used to detect prostate cancer cells in a sample and to distinguish between well differentiated (wd) prostate cancer and poorly differentiated (pd) prostate cancer.
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
|3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing|
The present invention relates generally to 3′-oh unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to dna and rna sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide..
|Preserving genomic connectivity information in fragmented genomic dna samples|
A method of sequencing a target nucleic acid polymer by (a) modifying a target nucleic acid polymer to produce a modified nucleic acid polymer; (b) producing fragments of the modified nucleic acid polymer, wherein the fragments are attached to locations on a solid support surface (c) determining nucleotide sequences from the fragments at the locations; and (d) producing a representation of the nucleotide sequence for the target nucleic acid polymer based on the nucleotide sequences from the fragments and the relative distances between the locations on the solid support surface.. .
|Microarray system with improved sequence specificity|
The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple snps (where the variation occurs at a fixed position and is of limited allelic number) to more complex sequence variation patterns (such as with multigene families or multiple genetic strains of an organism where the sequence variation between the individual members is neither fixed nor consistent). The array is comprised of short, synthetic oligonucleotide probes attached to a solid surface which are hybridized to single-stranded targets.
|Oligonucleotide inhibitor of dna polymerases|
The invention comprises a reversible oligonucleotide inhibitor of nucleic acid polymerases. Methods of designing said inhibitors and using said inhibitors in amplification and detection of nucleic acid, particularly detection of rna by rt-pcr are also disclosed..
Roche Molecular Systems, Inc.
|Methods and sequential amplification reactions|
The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample..
|Production of fatty alcohols from engineered microorganisms|
Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a β-ketoacyl acyl carrier protein synthase..
Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large subunit proteins, and methods of use
Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Use of cad genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant
Provided are methods of increasing nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide at least 80% identical to seq id no: 2560, 2557, 184, 238, 188, 154-156, 158-161, 163-183, 185-187, 189-197, 200-237, 239-264, 266-269, 1351, 1365-1425, 1429-1457, 1459, 1461-1730, 1735, 1739-2397, 2533-2541, 2544-2556, 2558, 2559, 2561-2562 or 2563. Also provided are isolated polynucleotides and polypeptides which can be used to increase nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant of a plant..
Methods of inducing insulin production
(ii) said srna is a single or double stranded rna molecule up to 30 nucleotides in length comprising a sequence of at least 13 nucleotides which has at least 95% complementarity to a region of the target transcript. Also provided are certain sarna molecules and uses thereof, particular medical uses, and induced cells and uses thereof..
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Selection in fungi
The present invention relates to methods for constructing a recombinant fungal host cell comprising one or more copies of a polynucleotide construct integrated in its genome, said method comprising transforming a fungal host cell with an integrative polynucleotide construct comprising a first polynucleotide encoding a selectable marker, wherein the first polynucleotide, a 5′ untranslated region thereof and/or a riboswitch operably linked therewith comprises a spliceosomal intron which has 5 nucleotides or less between its branch site and its acceptor site; and a second polynucleotide encoding a polypeptide of interest; as well as suitable polynucleotide constructs, resulting fungal host cells and methods of manufacture.. .
Novozymes A/s Of Krogshoejvej 36
Novel cell wall deconstruction enzymes of scytalidium thermophilum, myriococcum thermophilum, and aureobasidium pullulans, and uses thereof
The present invention relates to novel polypeptides and enzymes (e.g., thermostable proteins and enzymes) having activities relating to biomass processing and/or degradation (e.g., cell wall deconstruction), as well as polynucleotides, vectors, cells, compositions and tools relating to same, or functional variants thereof. More particularly, the present invention relates to secreted enzymes that may be isolated from the fungi, scytalidium thermophilum strain cbs 625.91, myriococcum thermophilum strain cbs 389.93, and aureobasidium pullulans strain atcc 62921.
Nucleic acid amplification reactor
Provided is a nucleic acid amplification reactor that can easily perform a nucleic acid amplification reaction. A nucleic acid amplification reactor 1 includes a reaction chamber 20 to which a thermoplastic hydrogel 50 is applied.
Production cell line enhancers
The present invention relates to discovery of the ectopic expression of edem2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the cho cell, containing recombinant polynucleotides encoding edem2.
Regeneron Pharmaceuticals, Inc.
Oil globule protein and uses thereof
An isolated novel oil globule protein encoded by a polynucleotide sequence is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a polynucleotide encoding a protein which at least partially comprises the amino acid sequence of the novel oil globule protein is also provided.
Yeda Research And Development Co. Ltd.
Circovirus sequences associated with piglet weight loss disease (pwd)
The genome sequences and the nucleotide sequences coding for the pwd circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a pwd circovirus, also are provided.
Zoetis W Llc
Targeted gene delivery for dendritic cell vaccination
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (dc). The virus envelope comprises a dc-sign specific targeting molecule.
California Institute Of Technology
Novel peptides and use thereof
The present invention relates to novel peptides and use thereof and more specifically is directed to a peptide with anti-inflammatory effect, a polynucleotide encoding the peptide, a pharmaceutical composition comprising the peptide or polynucleotide for preventing or treating inflammatory diseases, an anti-inflammatory drug, an over-the-counter (otc) drug composition comprising the peptide for preventing or ameliorating inflammation, a health food composition for alleviating or ameliorating inflammation, a cosmetic composition for preventing or ameliorating inflammation, a method for treating inflammatory diseases, comprising administrating the pharmaceutical composition to the subject suspected of having inflammatory disease, a method for preparing a mimetic of the peptide and a method for designing the same.. .
Samsung Life Public Welfare Foundation
Solid forms of a thiophosphoramidate nucleotide prodrug
The present application relates to solid state forms, for example, crystalline forms of 2′-c-methyluridine-5′-(o-phenyl-n-(s)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-c-methyluridine-5′-(o-phenyl-n-(s)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-c-methyluridine-5′-(o-phenyl-n-(s)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-c-methyluridine-5′-(o-phenyl-n-(s)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents..
Alios Biopharma, Inc.
Poxviral vectors for low antibody response after a first priming immunization
The invention is drawn to compositions and methods for the induction of an immune response, in particular a strong cd8 t cell response, to a specific antigenic determinant without raising a significant antibody response to the antigenic determinant after a first, priming immunization. The method comprises administering to the host a recombinant poxviral vector comprising a transcriptional control element comprising an early and/or late element linked to a nucleotide sequence encoding the antigenic determinant.
Bavarian Nordic A/s
Ube2t peptides and vaccines containing the same
Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the ube2t that elicit ctls are provided.
Onco Therapy Science, Inc.
Oligonucleotide based analyte detection method
The invention relates to a method of detecting the presence of an analyte within a sample, wherein said method comprises an oligonucleotide based approach. The invention also relates to methods of diagnosing diseases, in particular, but not exclusively infectious diseases such as septicaemia..
Loxbridge Research Llp
Nucleic acid molecule that binds to influenza viruses and use thereof
(d) a polynucleotide that has a base sequence complementary to a polynucleotide hybridizing to any of the base sequences of the polynucleotide (a) under stringent conditions and binds to the influenza virus.. .
A method for detecting a methylated genomic locus is provided. In certain embodiments, the method comprises: a) treating a nucleic acid sample that contains both unmethylated and methylated copies of a genomic locus with an agent that modifies cytosine to uracil to produce a treated nucleic acid; b) amplifying a product from the treated nucleic acid using a first primer and a second primer, wherein the first primer hybridizes to a site in the locus that contain methylcytosines and the amplifying preferentially amplifies the methylated copies of the genomic locus, to produce an amplified sample; and c) detecting the presence of amplified methylated copies of the genomic locus in the amplified sample using a flap assay that employs an invasive oligonucleotide having a 3′ terminal g or c nucleotide that corresponds to a site of methylation in the genomic locus..
Exact Sciences Corporation
Method for identifying increased risk of anxiety disorders
The present invention is for methods for identifying a human having an increased risk for anxiety disorders. The method involves genotyping the human for a specific brain-derived neurotrophic factor (bdnf) single nucleotide polymorphism (snp), and/or administering a fear conditioning procedure while measuring fear, and administering an extinction procedure while measuring fear.
Fret-based analytes detection and related methods and systems
Fret-based analytes detection and related methods and systems are described where a pair of fret labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the förster distance of the fret chromophores presented on the fret labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of fret labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring fret signals from at least one fret chromophore.. .
California Institute Of Technology
Gene mutations for the diagnosis of arthrogryposis multiplex congenita and congenital peripheral neuropathies disease
The present invention relates to a method of identifying a subject having or at risk of having or developing arthrogryposis multiplex congenita and/or congenital peripheral neuropathy, comprising determining, in a sample obtained from said subject, the presence or absence of a single nucleotide variant (snv) in cntnap1, adcy6, lgi4 or lmod3 genes. .
Association Francaises Contre Les Myopathies
Quantitative assessment of human t-cell repertoire recovery after allogeneic hematopoietic stem cell transplantation
A method and an apparatus are provided for determining t-cell repertoire recovery after allo-hsct or identifying patients at high risk of infection. Combination of 5′-race pcr with deep sequencing was used to quantify tcr diversity in 33 individuals using a single oligonucleotide pair.
Sloan Kettering Institute For Cancer Research
Genotyping test for assessing risk of autism
The invention relates to a method of determining a risk of, or of detecting the predisposition to or the presence of autism in a subject, the method comprising detecting the combined presence of risk-associated snp alleles at multiple loci in a sample from said subject, which method comprises genotyping a single nucleotide polymorphism (snp) in the gene loci of at least htr5a, macf1, rbfox1, abr, ptprg, cacna2d1, gfra1, dscaml1, chrm3, lppr4, dlg2, slc9a9 and basp1.. .
Nucleotide compositions and uses thereof
The present invention relates to preparation of nucleotide compositions and uses thereof for conducting nucleic acid analyses. The compositions and methods embodied in the present invention are particularly useful for nucleic acid analyses that require high-resolution detection of labeled nucleotides or labeled nucleic acid targets..
Pacific Biosciences Of California, Inc.
Polymethine compounds and their use as fluorescent labels
The present disclosure relates to new polymethine compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications..
Illumina Cambridge Limited
Dual enzymatic amplification
Provided are methods for validating the presence and character of genomic mutations, particularly single nucleotide polymorphisms (snps), by parallel amplification of a portion or the whole genome with at least two different dna polymerases.. .
Cynvenio Biosystems, Inc.
Human identification using a panel of snps
The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex pcr of one or more nucleic acids which belong to a panel of single nucleotide polymorphisms (snps) useful to identify a human. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences in the panel.
Life Technologies Corporation
Detection of nucleotide variation on target nucleic acid sequence by pto cleavage and extension assay
The present invention is generally drawn to a novel method and a kit for detecting nucleotide variations by a ptoce (pto cleavage and extension) assay with pto-nv. Furthermore, the present invention is directed to a novel method and a kit for detecting a nucleotide variation on a target nucleic acid sequence by a ptoce assay with pto-nv having a non-base paring moiety..
Detection of target nucleic acid sequence by pto cleavage and extension-dependent signaling oligonucleotide cleavage
The present invention relates to the detection of a target nucleic acid sequence by a pto cleavage and extension-dependent signaling oligonucleotide cleavage assay (pce-sc assay). The present invention is carried out in such a manner that the extended strand is produced on the cto having arbitrary sequences as templates depending on the presence of target nucleic acid sequences and in turn the so as probes is hybridized with the extended strand to give signal.
Detecting single nucleotide polymorphism using hydrolysis probes with 3' hairpin structure
Methods for the rapid detection of the presence or absence of a snp in a target nucleic acid in a sample are described. The methods can include performing an amplifying step, a hybridizing step utilizing a snp specific hydrolysis probe including a hairpin structure toward the 3′ end, and a detecting step.
Roche Molecular Systems, Inc.
Functional molecule, functional molecule synthesizing amidite and target substance analysis method
To provide a functional molecule including a modified nucleotide unit having a substituent introduced to a base thereof, wherein the substituent is removably introduced to the base; a functional molecule synthesizing amidite that has a substituent removably introduced to its base and that is used for the manufacture of the functional molecule; and a target substance analysis method including: preparing a random pool of functional molecules using a functional molecule synthesizing amidite; screening a functional molecule having affinity for a target substance from the random pool; amplifying the functional molecules having affinity for the target substance, wherein the method further comprises, prior to the amplification step, removing a substituent from the functional molecule having affinity for the target substance.. .
Apta Biosciences Ltd.
Stereospecific carbonyl reductases
Stereospecific carbonyl reductases scr1, scr2, and scr3 are described herein as are nucleotide sequences that encode these reductases. These stereospecific carbonyl reductases have anti-prelog selectivity and have specificities that are useful for fine biochemical synthesis..
Rutgers, The State University Of New Jersey
Recombinant cellulosome complex and uses thereof
The present invention relates to a polynucleotide encoding a recombinant scaffolding polypeptide comprising at least a signal peptide, a cellulose binding domain, two cohesin domains and an s-layer homology domain, wherein said isolated polynucleotide preferably comprises all or an active part of the nucleotide sequence as set forth in seq id no:2. The present invention further relates to vectors comprising such polynucleotides, recombinant lactic acid bacteria, and method for degrading a cellulosic biomass using such recombinant lactic acid bacteria..
Terpene synthases from santalum
An isolated nucleic acid molecule that encodes a terpene synthase and is selected from among: a) a nucleic acid molecule comprising the sequence of nucleotides set forth in seq id no: 1, seq id no: 3 or seq id no: 5; b) a nucleic acid molecule that is a fragment of (a); c) a nucleic acid molecule comprising a sequence of nucleotides that is complementary to (a) or (b); and d) a nucleic acid molecule that encodes a terpene synthase having at least or at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% identity to any one of (a)-(c); wherein the nucleic acid molecule encodes a terpene synthase.. .
Forest Products Commission
Methods and products for transfecting cells
The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using rna are disclosed.
Factor Bioscience Inc.
Alternative nucleic acid molecules and uses thereof
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.. .
Moderna Therapeutics, Inc.
Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
Provided are isolated polynucleotides, polypeptides encoded thereby, nucleic acid constructs comprising same, plant cells and plants comprising same and methods of generating plants with increased yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency, wherein the polynucleotides encode polypeptides at least 80% identical to seq id no: 574-930, 6266-10549 or 10550, such as the polynucleotides set forth in seq id nos:1-573, and 931-6265.. .
Plant regulatory elements and uses thereof
The present invention provides novel dna molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and plant cells. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising the dna molecules operably linked to heterologous transcribable polynucleotides, along with methods of their use..
Monsanto Technology Llc
Soybean ccp1 promoter and its use in constitutive expression of transgenic genes in plants
The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean copper chaperone homolog gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E. I. Du Pont De Nemours And Company
Antisense modulation of superoxide dismutase 1, soluble expression
Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble.
Isis Pharmaceuticals, Inc.
Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of sialidase 4 (neu4), in particular, by targeting natural antisense polynucleotides of sialidase 4 (neu4). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of neu4..
Methods for treating hypercholesterolemia
Disclosed herein are antisense compounds and methods for decreasing ldl-c in an individual having elevated ldl-c. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis.
Isis Pharmaceuticals, Inc.
Oligonucleotide inhibitors of dna methyltransferases and their use in treating diseases
Modified oligonucleotides comprising cpg sites, wherein the cytosine is replaced by cytosine analogs are provided as well as methods of making the oligonucleotides and their use in inhibiting dna methyltransferase, inhibiting or reversing methylation of genes and in treating cancer, tumorigenesis and hyper-proliferative disorders.. .
Metheor Therapeutics Corporation
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