Popular terms

[SEARCH]

Follow us on Twitter
twitter icon@FreshPatents

Web & Computing
Cloud Computing
Ecommerce
Search patents
Smartphone patents
Social Media patents
Video patents
Website patents
Web Server
Android patents
Copyright patents
Database patents
Programming patents
Wearable Computing
Webcam patents

Web Companies
Apple patents
Google patents
Adobe patents
Ebay patents
Oracle patents
Yahoo patents

[SEARCH]

Nucleotide patents



      
           
This page is updated frequently with new Nucleotide-related patent applications. Subscribe to the Nucleotide RSS feed to automatically get the update: related Nucleotide RSS feeds. RSS updates for this page: Nucleotide RSS RSS



Date/App# patent app List of recent Nucleotide-related patents
08/27/15
20150243917 
 Method for forming pn junction in graphene with application of dna and pn junction structure formed using the same patent thumbnailMethod for forming pn junction in graphene with application of dna and pn junction structure formed using the same
A method for forming a pn junction in graphene includes: forming a graphene layer, and forming a dna molecule layer on a partial region of the graphene layer, the dna molecule layer having a nucleotide sequence structure designed to provide the graphene layer with a predetermined doping property upon adsorption on the graphene layer. The dna molecule has a nucleotide sequence structure designed for doping of graphene so that doped graphene has a specific semiconductor property.
Korea Institute Of Science And Technology


08/27/15
20150242565 
 Method and device for analyzing microbial community composition patent thumbnailMethod and device for analyzing microbial community composition
The present teachings relate to analysis of a sample including a plurality of species. In one example, sequences of fragments of polynucleotides of the sample are obtained.
Bgi Shenzhen Co., Limited


08/27/15
20150240425 
 Laccase variants patent thumbnailLaccase variants
The present invention relates to variants of a parent laccase. The present invention also relates to polynucleotides encoding the variant laccases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes..
Novozymes A/s


08/27/15
20150240319 
 Global analysis of serum micrornas as potential biomarkers for lung adenocarcinoma patent thumbnailGlobal analysis of serum micrornas as potential biomarkers for lung adenocarcinoma
A diagnostic kit to detect lung adenocarcinoma, or to stratify patients according to expected prognosis comprising at least one oligonucleotide probe capable of binding to at least a portion of a circulating mirna selected from the group comprising mir-556, -550, -939, -616*, -146b-3p,-30c-1*,-339-5p and -656.. .
The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Hol


08/27/15
20150240316 
 Use of methylated or unmethylated line-1 dna as a cancer marker patent thumbnailUse of methylated or unmethylated line-1 dna as a cancer marker
The invention relates to a method of detecting line-1 (long interspersed nucleotide elements-1) dna either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using line-1 dna as a biomarker for diagnosing, predicting, and monitoring cancer progression and treatment..
John Wayne Cancer Institute


08/27/15
20150240313 
 Use of adcy3 for diagnosis and treatment of gastric cancer patent thumbnailUse of adcy3 for diagnosis and treatment of gastric cancer
The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mrna of adcy3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting adcy3 polynucleotide or adcy3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using adcy3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer..
National Cancer Center


08/27/15
20150240311 
 Recurrent transforming ubr5-znf423 fusion gene in ebv-associated nasopharyngeal carcinoma patent thumbnailRecurrent transforming ubr5-znf423 fusion gene in ebv-associated nasopharyngeal carcinoma
The present invention provides a method for diagnosing nasopharyngeal cancer in a subject by detecting ubr5-znf423 fusion polypeptide or polynucleotide, which is in some cases due to a gene fusion of ubr5-znf423. A kit useful for such a method is also provided.
The Chinese University Of Hong Kong


08/27/15
20150240310 
 Detection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation patent thumbnailDetection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation
Methods and compositions are described for detecting hydroxymethylated nucleotides (hmns) in a polynucleotide preparation with a view to mapping the location of hmns in a genome, quantifying the occurrence of hmns at selected loci and correlating the occurrence of hmns with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmns..
New England Biolabs, Inc.


08/27/15
20150240302 
 Methods and compositions for tagging and identifying polynucleotides patent thumbnailMethods and compositions for tagging and identifying polynucleotides
The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index submixtures in successively more complex sets of submixtures (referred to herein as “tiers” of submixtures) that a polynucleotide goes through while successive words are added to a growing tag.
Population Genetics Technologies Ltd


08/27/15
20150240300 
 Sensing apparatus and method patent thumbnailSensing apparatus and method
Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one isfet in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber.
Dna Electronics Ltd.


08/27/15
20150240295 

Reactive, lipophilic nucleoside building blocks for the synthesis of hydrophobic nucleic acids


The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with, essentially, complementary sequences (in the following referred to as sample oligo-nucleotides, sample sequences or sample nucleic acids), which belong to a library of sequences. Further, the invention relates to nucleolipids used in the method of the invention and a process for the preparation of said nucleolipids.
Ionovation Gmbh


08/27/15
20150240293 

Detection of an amplification reaction product using ph-sensitive dyes


Methods are provided for a rapid, low cost approach to monitoring an amplification reaction. This includes monitoring the progress of isothermal or pcr amplification reactions to completion using ph-sensitive dyes that are either colored or fluorescent.
New England Biolabs, Inc.


08/27/15
20150240285 

Muteins of the pyrroline-5-carboxylate reductase 1


The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (pycr1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with pycr1, to methods of identifying a compound capable of modifying the expression of pycr1, and methods of treating a subject having an age-related disorder associated with pycr1. The invention further relates to a genetically modified animal and a method of modifying the expression of the pycr1 gene in an animal..
Agency For Science, Technology And Research


08/27/15
20150240277 

Process for producing monosaccharides


The present invention relates to a process for producing a monosaccharide using a microorganism. The microorganism possesses a glycosyltransferase and a glycosidase which work together to synthesize a desired monosaccharide in free form by using an endogenous provided nucleotide activated monosaccharide, glycosylate a suitable acceptor substrate and release the desired monosaccharide by a hydrolysis reaction.
Jennewein Biotechnologie Gmbh


08/27/15
20150240264 

Methods for co-production of a terpene, succinate and hydrogen


The present disclosure generally relates to microorganisms (e.g., non-naturally occurring microorganisms) that comprise one or more polynucleotides coding for enzymes in a pathway that catalyze a conversion of a carbon source (e.g., a fermentable carbon source) to terpene, succinate, and hydrogen and the use of such microorganisms for the production of terpene, succinate, and hydrogen.. .
Braskem S.a.


08/27/15
20150240261 

Rna-directed dna cleavage by the cas9-crrna complex


Isolation or in vitro assembly of the cas9-crrna complex of the streptococcus thermophilus crispr3/cas system and use for cleavage of dna bearing a nucleotide sequence complementary to the crrna and a proto-spacer adjacent motif. Methods for site-specific modification of a target dna molecule using an rna-guided dna endonuclease comprising at least one rna sequence and at least one of an ruvc active site motif and an hnh active site motif; for conversion of cas9 polypeptide into a nickase cleaving one strand of double-stranded dna by inactivating one of the active sites (ruvc or hnh) in the polypeptide by at least one point mutation; for assembly of active polypeptide-polyribonucleotides complex in vivo or in vitro; and for re-programming a cas9-crrna complex specificity in vitro or using a cassette containing a single repeat-spacer-repeat unit..
Vilnius University


08/27/15
20150240259 

Pcp2 mini-promoters


Isolated polynucleotides comprising a pcp2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia


08/27/15
20150240258 

Compositions and methods for controlling leptinotarsa


Disclosed herein are methods of controlling insect pests, in particular leptinotarsa spp. Which infest crop plants, and methods of providing plants resistant to such pests.
Monsanto Technology Llc


08/27/15
20150240255 

Modulation of seed vigor


The present invention provides a polynucleotide which enables the modulation of the seed vigour, and in particular enhances the seed vigour, and more particularly enables the modification of the speed of germination. A plant seed comprising the said polynucleotide is also provided.
Syngenta Participations Ag


08/27/15
20150240253 

Long intergenic non-coding rnas in maize


The invention provides methods and compositions useful in altering gene expression. The invention provides polynucleotide constructs comprising useful for altering gene expression, as well as cells, plants and seeds comprising the polynucleotides.
E. I. Du Pont De Nemours And Company


08/27/15
20150240252 

Down-regulation of auxin responsive genes for improved plant performance


Methods for modulating plants using optimized zmsaur down-regulation constructs are disclosed. Also disclosed are nucleotide sequences, constructs, vectors, and modified plant cells, as well as transgenic plants displaying increased seed and/or biomass yield, improved tolerance to abiotic stress such as drought or high plant density, improved nitrogen utilization efficiency, increased ear tissue growth or kernel number..
Pioneer Hi-bred International, Inc.


08/27/15
20150240243 

Generating targeted sequence diversity in fusion proteins


Methods of generating fusion protein variants are provided that comprise introducing sequence diversity at the junction region or regions in the fusion and allows for the generation of variants having a desired activity. Examples include immunoglobulins comprising a domain or polypeptide inserted into, or replacing, a cdr.
Innovative Targeting Solutions Inc.


08/27/15
20150240242 

Compositions and methods for inhibiting expression of ikk-b gene


The invention relates to a double-stranded ribonucleic acid (dsrna) for inhibiting the expression of the ikk-b gene, comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the ikk-b gene. The invention also relates to a pharmaceutical composition comprising the dsrna together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression or activation of the ikk-b gene using the pharmaceutical composition; and methods for inhibiting the expression of the ikk-b gene in a cell..
Alnylam Pharmaceuticals, Inc.


08/27/15
20150240239 

Methods and pharmaceutical compositions for inhibiting matrix metalloproteinases 1 by interference ribonucleic acid


An interference ribonucleic acid containing specific sequence for inhibiting mmp1, which is composed of 19 to 25 nucleotides, wherein the interference ribonucleic acid has a sequence selected from the group consisted of the sequences as set forth in, or essentially identical to, seq id no: 5, seq id no: 6, seq id no: 7, seq id no: 8, seq id no: 9, and seq id no: 10. By means of the interference ribonucleic acid and mmp1 with high specificity binding, gene and protein expression of endogenous mmp1 of cancer cell can be inhibited, and then the interference ribonucleic acid can be used for pharmaceutical composition to prevent or treat cancer metastasis or to improve wrinkle resistance..
Nugen Biosience (taiwan) Co., Ltd.


08/27/15
20150240238 

Therapeutic rna switches compositions and methods of use


The invention provides for therapeutic rna switches comprising oligonucleotide sequences complementary to a trigger sequence, an antisense strand oligonucleotide, and a sense strand oligonucleotide complementary to a target nucleic acid molecule.. .
The Regents Of The University Of California


08/27/15
20150240237 

Compositions and methods for inhibiting expression of a gene from the jc virus


The invention relates to a double-stranded ribonucleic acid (dsrna) for inhibiting the expression of a gene from the jc virus (jc virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the jc virus. The invention also relates to a pharmaceutical composition comprising the dsrna together with a pharmaceutically acceptable carrier; methods for treating diseases caused by jc virus expression and the expression of a gene from the jc virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the jc virus in a cell..
Alnylam Pharmaceuticals, Inc.


08/27/15
20150240232 

Deducing exon connectivity by rna-templated dna ligation/sequencing


A technology is described that is capable of generating high-throughput sequencing (hts) read length dna products to accurately and reliably provide exon connectivity information for alternatively spliced isoforms. The method is not limited by the initial size of the isoform as the technology removes the template oligonucleotide sequence and a newly formed full length ligated product provides an hts-compatible read length sequence that comprises information that corresponds to the consecutive order of the exons in the original template oligonucleotide..
University Of Massachusetts


08/27/15
20150240228 

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases


Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited


08/27/15
20150240227 

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases


Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited


08/27/15
20150240226 

Nucleic acids and proteins and methods for making and using them


The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs..
Bp Corporation North America Inc.


08/27/15
20150240224 

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.


08/27/15
20150240218 

Polypeptides having peroxygenase activity


The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Novozymes A/s


08/27/15
20150240217 

Ketoreductase-mediated stereoselective route to alpha chloroalcohols


The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
Codexis, Inc.


08/27/15
20150239987 

Complement factor bb antibodies


The present disclosure relates to antibodies and polynucleotides encoding the same, which may be used to prevent, control, or reduce the activity of the complement pathway. In addition, the disclosure is directed to compositions and methods for diagnosing and treating diseases mediated by or involving complement factor bb.
Allergan, Inc.


08/27/15
20150239975 

Novel monoclonal antibody which is specifically bound to tm4sf5 protein and use thereof


The present invention relates to a novel monoclonal antibody which is specifically bound to a transmembrane 4 l six family member 5 (tm4sf5) protein. More particularly, the present invention relates to a monoclonal antibody which is specifically bound to a human tm4sf5 protein, to polynucleotides coding for the monoclonal antibody, to an expression vector comprising the nucleotides, to a transformant with the vector introduced thereto, to a method for preparing the monoclonal antibody, to a composition comprising the monoclonal antibody, to a method for treating liver fibrosis using the monoclonal antibody, to a method for treating cancer using the monoclonal antibody, to a method for inhibiting metastasis of cancer, to a method for diagnosing cancer using the monoclonal antibody and to a cancer diagnosis kit comprising the monoclonal antibody..
Snu R&db Foundation


08/27/15
20150239966 

Complement component c5 antibodies


The present disclosure relates to antibodies and polynucleotides encoding the same, that may be used to prevent, control, or reduce the activity of the complement pathway. In addition, the disclosure is directed to compositions and methods for diagnosing and treating diseases mediated by or involving complement c5.
Xencor, Inc.


08/27/15
20150239828 

Methods and systems for purifying an acetonitrile waste stream and methods for synthesizing oligonucleotides using purified acetonitrile waste streams


Methods and systems for purifying an acetonitrile waste stream and methods for synthesizing an oligonucleotide using a purified acetonitrile waste stream are provided. An exemplary method for purifying an acetonitrile waste stream includes providing an acetonitrile waste stream and fractionating the acetonitrile waste stream to produce a single overhead fraction.
Honeywell International Inc.


08/27/15
20150238627 

Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy


Provided herein are peptide-linked morpholino (ppmo) antisense oligonucleotides that target the poly cug repeat tract in the 3′ untranslated region of the gene encoding dystrophia myotonica-protein kinase (dmpk) and methods for systemic administration of the same for the treatment of mytonic dystrophy type i (dm1).. .
Genzyme Corporation


08/27/15
20150238619 

Polymeric carrier


Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g., oligonucleotides) and/or other therapeutic agents into a living cell.. .
University Of Washington


08/27/15
20150238517 

Methods and compositions for treating cancer


Treatment of cancer by regional and prolonged release of one or more nucleotide-based agents is provided.. .
Silenseed Ltd.


08/27/15
20150238516 

Polynucleotides having bioreversible groups


The disclosure provides methods and compositions for delivering polynucleotides into cells. The disclosure provides transiently protected polynucleotides comprising an anionic charge-neutralizing moiety/group, which may also confer additional functionality.
The Regents Of The University Of California


08/20/15
20150234980 

Genome sequence systems and methods


According to embodiments of the invention, systems and methods are provided for capturing nucleotide sequence and providing associated modification snapshots with timestamps. The system and/or method are adapted to receive a sample containing a genome sequence from an individual or an organism (hereinafter collectively referred to as a “subject”) that uses the genome for encoding dna or rna.

08/20/15
20150232957 

Modified oligonucleotides comprising thiol functions and use thereof for detecting nucleic acids


The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample.
Universite Claude Bernard Lyon 1


08/20/15
20150232954 

Method for quantifying different viral forms of the dna of the hiv virus


The invention relates to a method for quantifying linear forms of the dna genome of the human immunodeficiency virus 1 (hiv-1) in a sample, wherein: a ligation reaction is performed with a double-stranded oligonucleotide suitable for ligation with the linear form of the hiv-1 dna genome having a mature 3′ end and/or the linear form of the hiv-1 dna genome having a non-mature 3′ end; a quantitative pcr is carried out from the ligation product obtained in the previous step; and the quantity of the linear form of the hiv-1 dna genome having a mature 3′ end and/or the quantity of the linear form of the hiv-1 dna genome having a non-mature 3′ end in the sample are deduced therefrom.. .
Ecole Normale Superieure De Cachan


08/20/15
20150232941 

Method of diagnosing cancer comprising detection of the methylation signature in the htert promoter


A method of diagnosing cancer in a mammal is provided. The method includes the steps of determining in a nucleic acid-containing sample from the mammal the degree of dna methylation of a target region within the htert promoter from the nucleotide at about position −157 to the nucleotide at about position −580, or a corresponding target region in a tert promoter in a mammal other than a human, to yield a sample methylation signature, determining the baseline degree of dna methylation of the target region in a control sample to yield a control methylation signature, comparing the sample methylation signature to the control methylation signature and rendering a diagnosis of cancer when there is at least 1.5 times more methylation in the sample methylation signature as compared to the control methylation signature.
The Hospital For Sick Children


08/20/15
20150232932 

Ankrd26 as a marker for diagnosis of thrombocytopenias


An in vitro method for diagnosing thrombocytopenia in a subject, the method includes the step of assessing the ankrd26 platelet expression in a biological sample from the subject, wherein a ankrd26 platelet expression is indicative of a thrombocytopenia. Also described is a kit for diagnosing a thrombocytopenia in a subject, which includes at least one ankrd26 nucleic acid probe or oligonucleotide or antibody for assessing the ankrd26 platelet expression in a biological sample from the subject..
Institut Gustave Roussy


08/20/15
20150232928 

Real-time sequencing single molecule


This invention is to describe a method for the determination of a nucleic acid sequence, in which it involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.. .
Personal Genomics, Inc.


08/20/15
20150232925 

Sequencing method


Typically the biological probe employed comprises a single-stranded nucleotide region the ends of which are attached to two different oligonucleotide regions wherein at least one of the oligonucleotide regions comprises detectable elements having a characteristic detection property and wherein the detectable elements are so arranged on the oligonucleotide region that the detectable property is essentially undetectable in the probe's unused state. In a most preferred embodiment the probe is labelled with multiple fluorophores and further comprises a restriction enzyme recognition site generated by the binding of the target single nucleotide to the single-stranded nucleotide region.

08/20/15
20150232924 

Strategies for high throughput identification and detection of polymorphisms


The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe.. .
Keygene N.v.


08/20/15
20150232918 

Analyzing messenger rna and micro rna in the same reaction mixture


The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucleotide with a hot start primer comprising a self-complementary stem and a loop, and extension products form at high temperatures but extension products form less so at low temperatures since the self-complementary stem of the hot start primer prevents hybridization of the target specific region to the target.
Applied Biosystems, Llc


08/20/15
20150232915 

Method for real-time single molecule sequencing


This invention is to describe a method for the determination of a nucleic acid sequence, in which it involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.. .
Personal Genomics, Inc.


08/20/15
20150232905 

Methods of activating clostridial toxins


The specification discloses modified clostridial toxins comprising an exogenous clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified clostridial toxins; method of producing such modified clostridial toxins, method of activating such modified clostridial toxins and methods of activating recombinantly-expressed clostridial toxins.. .
Allergan, Inc.


08/20/15
20150232894 

Lactate dehydrogenase mutant, polynucleotide coding for the mutant, yeast cell including the polynucleotide, preparing the mutant, and producing the lactate using the same


A lactate dehydrogenase mutant, a polynucleotide encoding the mutant, a recombinant yeast cell including the polynucleotide, and a method of preparing the mutant and a method of producing lactate by using the same.. .
Samsung Electronics Co., Ltd.


08/20/15
20150232868 

Down-regulation of bzip transcription factor genes for improved plant performance


Methods for modulating plants using optimized zmbzip down-regulation constructs are disclosed. Also disclosed are nucleotide sequences, constructs, vectors, and modified plant cells, as well as transgenic plants displaying increased seed and/or biomass yield, improved tolerance to abiotic stress such as drought or high plant density, improved nitrogen utilization efficiency, increased ear tissue growth or kernel number..
Pioneer Hi-bred International Inc.


08/20/15
20150232867 

Heavy metal reduction in planta


There is described a mutant, non-naturally occurring or transgenic plant or plant cell comprising (a) a polynucleotide selected from the group consisting of: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 71% sequence identity to seq id nos: 1, 2, 27, 28 or 29 or 51; or (ii) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 65% sequence identity to any of seq id nos: 3 to 23 or 30 to 50; or (iii) a polynucleotide encoding a ntmrp polypeptide comprising, consisting or consisting essentially of a sequence having at least 65% sequence identity to any of seq id nos. 24 to 26 or 52, and wherein the polypeptide has heavy metal transporter activity; or (b) a polynucleotide construct of at least 15 contiguous nucleotides in length that is at least 65% identical to a region of any of seq id nos: 1 to 23 or 27 to 51; or (c) a double-stranded rna comprising at least two sequences that are at least partially complementary to each other and wherein a sense strand comprises a first sequence and an antisense strand comprises a second sequence and wherein at least one of the sequences comprises at least 10 contiguous nucleotides of ntmrp rna; or (d) an expression vector comprising the polynucleotide as set forth in (i), (ii) or (iii) or the polynucleotide construct as set forth in (b)..
Philip Morris Products S.a.


08/20/15
20150232866 

Plant regulatory elements and uses thereof


The present invention provides novel dna molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and plant cells. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising the dna molecules operably linked to heterologous transcribable polynucleotides, along with methods of their use..
Monsanto Technology Llc


08/20/15
20150232860 

Multi-species polynucleotide control sequences


The present invention relates to polynucleotide sequences which enable a polynucleotide control sequence, such as a promoter, to direct expression in a wide range of industrially relevant species, both prokaryotes and eukaryotes. When the polynucleotide sequences of the invention are applied in combination with selection marker genes it is possible to perform selectable cloning in a laboratory host and use the same construct in the final host.
Dsm Ip Assets B.v.


08/20/15
20150232858 

Euchromatic region targeting methods for modulating gene expression


Provided herein are oligonucleotides complementary to euchromatic regions of target genes that are useful for increasing expression of the target genes; related compositions and methods are also provided.. .
Rana Therapeutics, Inc.


08/20/15
20150232857 

Oligonucleotide-containing pharmacological compositions and their use


The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.. .
Lakewood-amedex, Inc.


08/20/15
20150232854 

Antisense compositions and methods of making and using same


The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against smad7. The pharmaceutical formulations can be used to treat crohn's disease, ulcerative colitis and chronic inflammatory bowel disease..
Nogra Pharma Limited


08/20/15
20150232852 

Glucagon binding nucleic acids


Wherein the sequence of nucleotides of the nucleic acid molecule consists of both ribonucleotides and deoxyribonucleotides and wherein the sequence of nucleotides of the reference nucleic acid molecule consists of either ribonucleotides or deoxyribonucleotides.. .

08/20/15
20150232851 

Una oligomers targeting micro-rna for therapeutics


This invention provides una oligomers for therapeutics that can be used to target micro-rnas. The una oligomers can be composed of one or more 2′-3′-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers, and can be a single stranded oligomer.
Arcturus Therapeutics, Inc.


08/20/15
20150232850 

Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of insulin receptor substrate 2 (irs2) polynucleotides, in particular, by targeting natural antisense polynucleotides of insulin receptor substrate 2 (irs2) polyneucleotides and transcription factor e3 (tfe3). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of irs2..
Curna, Inc.


08/20/15
20150232849 

Una duplex oligomers for therapeutics


This invention provides una oligomers for therapeutics that can be used to modulate or reduce gene expression. The una oligomers can be composed of one or more 2′-3′-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers, and can be a duplex having first and second strands.
Arcturus Therapeutics, Inc.


08/20/15
20150232847 

Targeting oligonucleotides and related methods for modulating fxn rna


Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/20/15
20150232846 

Pseudocircularization oligonucleotides for modulating rna


Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/20/15
20150232845 

5' targeting oligonucleotides for modulating rna


Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/20/15
20150232844 

Methods for modulating rna using 5' targeting oligonucleotides


Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or rna levels in a targeted manner.
Rana Therapeutics, Inc.


08/20/15
20150232843 

Compositions and methods for treatment of prostate and other cancers


Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp27. A therapeutic agent, for example an antisense oligonucleotide or rnai nucleotide inhibitor with sequence specificity for hsp27 mrna, for example human hsp27 mrna, is administered to an individual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount.
The University Of British Columbia


08/20/15
20150232839 

Splice-region antisense composition and method


Antisense compositions targeted against an mrna sequence coding for a selected protein, at a region having its 5′ end from 1 to about 25 base pairs downstream of a normal splice acceptor junction in the preprocessed mrna, are disclosed. The antisense compound is rnase-inactive, and is preferably a phosphorodiamidate-linked morpholino oligonucleotide.
Sarepta Therapeutics, Inc.


08/20/15
20150232838 

Effects of apolipoprotein b inhibition on gene expression profiles in animals


Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein b. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein b.
Genzyme Corporation


08/20/15
20150232836 

Compositions and methods for modulating gene expression


Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of a target gene. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of a target gene.
The General Hospital Corporation


08/20/15
20150232834 

Partitioning of dna sequencing libraries into host and microbial components


Described herein is a method for isolating microbial dna from a sample that comprises host dna and microbial dna. In some embodiments, the method may comprise: obtaining a tagged dna sample, wherein the tagged dna sample contains host dna and microbial dna, both comprising an appended universal adaptor; b) hybridizing the extracted dna, in solution, with affinity-tagged rna probes generated by in vitro transcribing, in the presence of an affinity-tagged ribonucleotide, a library of fragmented host dna that has been ligated to an rna promoter adaptor; c) binding the product of step b) with a capture agent that is tethered to a substrate, in the presence of rna oligonucleotides that are complementary to or have the same sequence as one or more strands of the universal adaptor, thereby capturing the host dna on the substrate; and d) collecting the unbound dna, wherein the unbound dna comprises the microbial dna..
The Board Of Trustees Of The Leland Stanford Junior University


08/20/15
20150232825 

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


Provided are isolated polypeptides having cellulolytic enhancing activity, and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using polypeptides..
Novozymes A/s


08/20/15
20150232824 

Glucoamylase variants and polynucleotides encoding same and uses thereof


The present invention relates to variants of a parent glucoamylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the glucoamylase variants..
Novozymes A/s


08/20/15
20150232822 

Dna polymerases having improved labeled nucleotide incorporation properties


In addition to providing novel mutant dna polymerases, the invention also provides polynucleotides encoding the subject mutant dna polymerases. The polynucleotides provided may comprise expression vectors for the recombinant production of the mutant polymerases.

08/20/15
20150232817 

Polypeptides having peroxygenase activity


The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Novozymes A/s


08/20/15
20150232816 

Polypeptides having peroxygenase activity


The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Novozymes A/s


08/20/15
20150232494 

Reagents useful for synthesizing rhodamine-labeled oligonucleotides


The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.. .
Applied Biosystems, Llc




Popular terms: [SEARCH]



Follow us on Twitter
twitter icon@FreshPatents

###

This listing is a sample listing of patent applications related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.


0.4062

7295

2 - 1 - 149