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Nucleotide

Nucleotide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method of characterizing sequences from genetic material samples
The Translational Genomics Research Institute
July 20, 2017 - N°20170206311

Among other aspects provided herein is a method describing the use of single nucleotide polymorphism (snp) genotyping microarrays to resolve whether genetic material (such as genomic dna) derived from a particular individual is present in a genetic material mixture (such as a complex genomic dna mixture) is disclosed. Furthermore, it is demonstrated that the identification of the presence of genetic ...
Microrna polymorphisms conferring enhanced drought tolerance in a plant
Syngenta Participations Ag
July 20, 2017 - N°20170204476

Methods of identifying a single nucleotide polymorphism associated with a plant trait and methods of identifying a plant having an improved trait. The plant trait is correlated with at least one single nucleotide polymorphism in a microrna region of a plant genome. Isolated nucleic acids, transgenic plants, and methods of producing the same are also disclosed.
Bulk allele discrimination assay
General Mills, Inc.
July 20, 2017 - N°20170204474

A method is described for bulk allele discrimination of multiple single nucleotide polymorphisms in multiple individuals. Also described is a kit for use in performing a method for bulk allele discrimination of multiple single nucleotide polymorphisms in multiple individuals.
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Methods and compositions for detecting gastrointestinal and other cancers
Case Western Reserve University
July 20, 2017 - N°20170204470

This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.
Method for predicting risk of ankylosing spondylitis using dna copy number variants
Catholic University Industry Academic Cooperation Foundation
July 20, 2017 - N°20170204463

The present invention relates to a method of predicting the risk of developing ankylosing spondylitis using dna copy number variation. It was verified that the risk of developing ankylosing spondylitis can be effectively predicted using primers for detecting dna copy number variation, of the present invention, and the sensitivity and specificity of prediction can be improved by grafting the results ...
Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, ...
Cornell University
July 20, 2017 - N°20170204459

The present invention relates to a method for the highly specific, targeted capture of regions of human genomes and transcriptomes from the blood, i. E. From cell free circulating dna, exosomes, microrna, circulating tumor cells, or total blood cells, to allow for the highly sensitive detection of mutation, expression, copy number, translocation, alternative splicing, and methylation changes using combined nuclease, ...
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Nucleotide Patent Applications
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Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at ...
Oxford Nanopore Technologies Ltd.
July 20, 2017 - N°20170204457

The invention relates to a method for method of characterising, such as sequencing, a target double stranded polynucleotide. The polynucleotide is coupled to a membrane using at least two adaptors with different strengths of coupling to the membrane.
Method for the detection of sepsis
Oxford Nanopore Technologies Ltd.
July 20, 2017 - N°20170204452

The invention relates to an in vitro method for the detection and/or identification of a human pathogen and/or genetic material thereof comprising subjecting a sample comprising or suspected of comprising a human pathogen and/or genetic material thereof to a multiplex real-time polymerase chain reaction (rt-pcr), wherein said method comprises amplification of pcr products that enable discrimination between ...
Polypeptides having glucoamylase activity and polynucleotides encoding same
Novozymes North America, Inc.
July 20, 2017 - N°20170204435

The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress ...
Evogene Ltd.
July 20, 2017 - N°20170204428

Polynucleotides, polypeptides, plant cells expressing same and methods of using same for increasing abiotic stress tolerance water use efficiency (wue), fertilizer use efficiency (fue), biomass, vigor and/or yield of a plant. The method is effected by expressing within the plant an exogenous polynucleotide encoding a polypeptide comprising an amino acid sequence at least 80% homologous to the amino acid sequence ...
Circular polynucleotides
Moderna Therapeutics, Inc.
July 20, 2017 - N°20170204422

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
Alnylam Pharmaceuticals, Inc.
July 20, 2017 - N°20170204418

The invention relates to polynucleotide agents, e. G., antisense polunucleotide agents, targeting the alas1 gene, and methods of using such agents to alter (e. G., inhibit) expression of alas1 and to treat alas1 associated diseases, e. G., porphyria.
Dsrna for treating viral infection
Arrowhead Pharmaceuticals, Inc.
July 20, 2017 - N°20170204417

The invention relates to double-stranded ribonucleic acids (dsrnas) targeting gene expression of phosphatidylinositol 4-kinase (pi4k), in particular human phosphatidylinositol 4-kinase, catalytic, beta polypeptide (pik4cb) or human phosphatidylinositol 4-kinase, catalytic, alpha polypeptide (pik4ca), and their use for treating infection by positive stranded rna viruses such as hepatitis c virus (hcv). Each dsrna comprises an antisense strand having a ...
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Nucleotide Patent Applications
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  • 1871+ full patent PDF documents of Nucleotide-related inventions.
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Oligonucleotide comprising an inosine for treating dmd
Biomarin Technologies B.v.
July 20, 2017 - N°20170204414

The invention provides an oligonucleotide comprising an inosine, and/or a nucleotide containing a base able to form a wobble base pair or a functional equivalent thereof, wherein the oligonucleotide, or a functional equivalent thereof, comprises a sequence which is complementary to at least part of a dystrophin pre-m rna exon or at least part of a non-exon region of ...
Oligomers
Royal Holloway, University Of London
July 20, 2017 - N°20170204413

Molecules are provided for inducing or facilitating exon skipping in forming spliced mrna products from pre-mrna molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like duchene muscular dystrophy so ...
Modifications for antisense compounds
Integrated Dna Technologies, Inc.
July 20, 2017 - N°20170204412

The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic sirnas and mirnas.
Method for controlling obesity using minimally invasive means
Integrated Dna Technologies, Inc.
July 20, 2017 - N°20170204409

Methods for controlling obesity using minimally-invasive procedures including introducing embolic crystal particles that are naturally occurring and mostly non-toxic salts into the arterial capillaries feeding the sections of the stomach where the appetite inducing hormone, ghrelin, is produced to limit the blood flow to the region reducing appetite; introducing a virus vector or antisense oligonucleotide to inhibit the production of ...
Method for counting number of nucleic acid molecules
Osaka Prefectural Hospital Organization
July 20, 2017 - N°20170204406

The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately. This is a method for highly accurately counting the number of nucleic acid molecules by detecting the read errors that occur when determining a nucleic acid base sequence, wherein ...
Modified microorganisms comprising an optimized system for oligosaccharide utilization and methods of using same
Braskem S.a.
July 20, 2017 - N°20170204394

The present disclosure generally relates to modified microorganisms comprising an optimized system for oligosaccharide utilization comprising one or more polynucleotides coding for one or more energy independent oligosaccharide transporters for transporting an oligosaccharide into the microorganism, one or more polynucleotides coding for enzymes that catalyze the conversion of the oligosaccharide into at least one phosphorylated saccharide, and one or more ...
Polypeptides having protease activity and polynucleotides encoding same
Novozymes A/s
July 20, 2017 - N°20170204392

The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Biocatalysts for ezetimibe synthesis
Codexis Inc.
July 20, 2017 - N°20170204378

The present disclosure relates to non-naturally occurring polypeptides useful for preparing ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
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