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Nucleotide patents

      

This page is updated frequently with new Nucleotide-related patent applications.




new patent Ancestral-specific reference genomes and methods of constructing
Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System


new patent Ancestral-specific reference genomes and uses in selecting an egg, embryo, or sperm
Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System


new patent Ancestral-specific reference genomes and uses in identifying an individual attribute
Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System


new patent Ancestral-specific reference genomes and uses in determining response to an active agent
Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System


new patent Ancestral-specific reference genomes and uses in determining prognosis
Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System


new patent Ancestral-specific reference genomes and uses in identifying a candidate for a clinical trial
Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System


new patent Methods for retrievable information storage using nucleic acids
A method of storing information using monomers such as nucleotides is provided including converting a format of information into a plurality of bit sequences of a bit stream with each having a corresponding bit barcode, converting the plurality of bit sequences to a plurality of corresponding oligonucleotide sequences using one bit per base encoding, synthesizing the plurality of corresponding oligonucleotide sequences on a substrate having a plurality of reaction locations, and storing the synthesized plurality of corresponding oligonucleotide sequences.. .
President And Fellows Of Harvard College


new patent Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
Methods and kits for diagnosing systemic lupus erythematosus (sle) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing sle in a subject..
Yeda Research And Development Co. Ltd.


new patent Apparatus and electrical detection of oligonucleotides through pore blockades
Systems and methods for specific nucleic acid (na) sequence detection that do not rely on polymerase chain reaction (pcr) for target sequence amplification and do not require any special reagents other than a complementary sequence capture probe conjugated to spherical beads.. .
The Regents Of The University Of California


new patent Methods for assessing risk of alzheimer's disease in a patient
Disclosed are methods for diagnosis or prognosis of alzheimer's disease in a patient. The methods may include assessing whether a patient has alzheimer's disease or assessing a patient's risk for developing alzheimer's disease.
Wisconsin Alumni Research Foundation


new patent

Single nucleotide polymorphisms (snp) and association with resistance to immune tolerance induction

This application discloses methods, systems and kits for correlating the presence or absence of certain nucleic acid sequences within a population with the ability to create immune tolerance in that same population. Tolerance can be induced by solo or repeated administration of antigen, including soluble antigens administered either intravenously or sublingually.
University Of Tennessee Research Foundation

new patent

Nucleic acid probe and detecting genomic fragments

Provided herein, among other things, is a method of processing a nucleic acid sample. In some embodiments, the method comprises a) hybridizing a sample comprising a target fragment to a nucleic acid probe comprising: i.
Vanadis Diagnostics

new patent

Method for reducing dephasing during cluster dna sequencing

A method for nucleic acid sequencing, comprising: exposing a plurality of clusters of a plurality of template polynucleotide strands to a series of flows of a plurality of nucleotide or oligonucleotide solutions, wherein the nucleotide solutions or oligonucleotide solutions are flowed in an order of flow which is not a continuous repeat of an ordering of a single flow of each of the nucleotide solutions or oligonucleotide solutions; and obtaining a fluorescence signal indicative of which, if any, nucleotide species or oligonucleotide species incorporated to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands. This method enables dephased amplicons to return in-phase..

new patent

Accurate detection of rare genetic variants in next generation sequencing

The invention relates to a method for analyzing a target nucleic acid fragment, comprising generating a first strand using one strand of the target as a template by primer extension, using a first oligonucleotide primer which comprises, from 5′ to 3′, an overhang adaptor region, a primer id region and a target specific sequence region complementary to one end of the target fragment; optionally removing non-incorporated primers; amplifying the target from the generated first strand to produce an amplification product; and detecting the amplification product. Also disclosed are unique primers useful for such target analysis methods..
Ge Healthcare Bio-sciences Corp.

new patent

Dna methylation detection

The present invention relates to a method for detecting methylation of a target oligonucleotide molecule. The method comprises obtaining an electrical change occurring due to the binding of an electrically charged methylation detecting molecule and the target oligonucleotide molecule; wherein the electrically charged methylation detecting molecule has affinity to a methylated cytosine nucleotide.
Orizhan Bioscience Limited

new patent

Methods and compositions for isolating polynucleotides

Methods of isolating target double-stranded polynucleotides with internal single-stranded regions are provided. Compositions and kits comprising double-stranded polynucleotides with internal single-stranded regions are also provided..
Swift Biosciences, Inc.

new patent

Test strip and measuring the content of alcohol in blood, or of any other substance in blood, and a measuring the content of alcohol in blood

A test strip for measuring the blood alcohol content from blood includes a base material and two electrodes attached to it and a reaction area connected to both electrodes, to which area nicotin—amide adenine dinucleotide (nad+) and alcohol dehydrogenase enzyme (adh) are applied as reagents. A sample opening is connected to the reaction area, from which opening the blood sample to be measured can be transferred to the reaction area to dissolve the reagents and optional auxiliary substances, and at the same time into contact with both electrodes.
Pal Finland Oy

new patent

Novel dna-binding proteins and uses thereof

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel dna-binding domains, including tale dna-binding domains. Also disclosed are methods of using these novel dna-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences..
Sangamo Biosciences, Inc.

new patent

Hppd variants and methods of use

In particular, isolated polynucleotides encoding hppd inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed..

new patent

Method of treating cancer by inhibition of dna repair proteins

Methods of treating cancer using antisense oligonucleotides directed against dna double-strand break repair proteins such as brca2 or rad51 are provided. The antisense oligonucleotides can he used alone, in tandem or in combination with other cancer therapies, in particular with therapies that lead to dna damage, inhibition of dna repair or inhibition of dna synthesis, such as radiation, platinum drugs, alkylating agents, parp inhibitors, or inhibitors of thymidylate synthase..
Sarissa Inc.

new patent

Low molecular weight cationic lipids for oligonucleotide delivery

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver.
Sirna Therapeutics, Inc.

new patent

Dual targeting antisense oligonucleotides as apoptotic inhibtor therapeutic compostions and methods for their use in the treatment of cancer

Provided herein are compositions, method and uses for modulating iap activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (daso) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of birc6, ciap1 or survivin.

new patent

Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same

The present invention relates to isolated polypeptides having alpha-glucuronidase activity, catalytic domains and polynucleotides encoding the polypeptides, catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains..
Novoyzmes A/s

new patent

Polypeptides with lipase activity and polynucleotides encoding same

Provided are isolated polypeptides with lipase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the polypeptides..
Novozymes A/s

new patent

Tetracycline resistant eukaryotic cells expressing an nadp-requiring oxidoreductase

Tetx, a tetracycline degrading enzyme, is provided as a selection marker for eukaryotic cells. Polynucleotide molecules containing tetx and dna constructs comprising a tetx under the control of a eukaryotic promoter are provided.
Instituto Tecnológico Y De Estudios Superiores De Monterrey

new patent

Polypeptides having alpha amylase activity

The present invention relates to polypeptides having alpha-amylase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s

new patent

Nucleic acids encoding human antibodies to sialyl-lewis a

The present invention provides compositions for the production of an antibody or functional fragment thereof directed against sialyl-lewisa (slea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to slea.
Mabvax Therapeutics, Inc.

new patent

Human antigen binding proteins that bind betta-klotho, fgf receptors and complexes thereof

The present invention provides compositions and methods relating to or derived from antigen binding proteins activate fgf21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-klotho; (ii) fgfr1c, fgfr2c, fgfr3c or fgfr4; or (iii) a complex comprising β-klotho and one of fgfr1c, fgfr2c, fgfr3c, and fgfr4.
Amgen Inc.

new patent

Cd86 antagonist multi-target binding proteins

This disclosure provides a multi-specific fusion protein composed of a cd86 antagonist binding domain and another binding domain that is an il-10 agonist, an hla-g agonist, an hgf agonist, an il-35 agonist, a pd-1 agonist, a btla agonist, a light antagonist, a gitrl antagonist or a cd40 antagonist. The multi-specific fusion protein may also include an intervening domain that separates the other domains.
Aptevo Research And Development Llc

new patent

Recombinant human interferon-like proteins

This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology in described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon like alpha 2b (huifn-α2b).
Novagen Holding Corporation

new patent

Partially neutral single-stranded oligonucleotide

The present invention relates to a detection unit comprising a solid surface and a partially neutral single-stranded oligonucleotide comprising a first portion. The first portion is attached to the solid surface; the length of the first portion is about 50% of the total length of the partially neutral single-stranded oligonucleotide; and the first portion comprises at least one neutral nucleotide and at least one unmodified nucleotide.
Orizhan Bioscience Limited

new patent

Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease

The present invention relates to compositions and methods for preparing splice variants of tnfalpha receptor (tnfr) in vivo or in vitro, and the resulting tnfr protein variants. Such variants may be prepared by controlling the splicing of pre-mrna molecules and regulating protein expression with splice switching oligonucleotides or splice switching oligomers (ssos).
Roche Innovation Center Copenhagen A/s





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This listing is a sample listing of patent applications related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.


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