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Nucleotide patents

      

This page is updated frequently with new Nucleotide-related patent applications.




 Small molecule binding pockets in nucleic acids patent thumbnailSmall molecule binding pockets in nucleic acids
Described herein is technology for determining the 2-d or 3-d atomic resolution structure of a polynucleotide bound to and/or interacting with another molecule, for example a small molecule. In some aspects of the technology, nmr and isotopic labeling strategies are used.
Nymirum, Inc.


 Spectral  quantifying hemoglobin fragility caused by smoking patent thumbnailSpectral quantifying hemoglobin fragility caused by smoking
The spectral method for quantifying hemoglobin fragility caused by smoking is based on decreased concentration of tryptophan and elevated concentrations of the biomolecules nicotinamide adenine dinucleotide (nadh), flavin adenine dinucleotide (fad), and porphyrin in the presence of hemoglobin fragility. The method involves the steps of obtaining a blood sample from a patient who is a smoker; separating blood plasma from the samples; obtaining synchronous excitation spectra (sxs) of the blood plasma with a spectrofluorometer at a scan offset of 70 nm and at a scan offset of 10 nm; comparing the patient's sxs with the sxs of normal control samples; and diagnosing hemoglobin fragility when the excitation maxima of nadh, fad, and porphyrin are between 30% and 70% higher than the maxima for these metabolites in the normal control samples, or when the excitation maximum for tryptophan is 60% of the control sample..
King Saud University


 Methods for treating textiles using polypeptides having endoglucanase activity patent thumbnailMethods for treating textiles using polypeptides having endoglucanase activity
The present invention relates to isolated polypeptides having endoglucanase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules..
Novozymes A/s


 Determining prostate cancer recurrence using polymorphisms in angiogenesis-related genes patent thumbnailDetermining prostate cancer recurrence using polymorphisms in angiogenesis-related genes
In particular, disclosed is a method for treating a patient with prostate cancer that involves genotyping a nucleic acid sample from the subject for one or more single nucleotide polymorphism (snp) alleles in one or more genes angiogenesis, comparing the one or more snp alleles to control allele frequencies to produce a snp signature, and analyzing the snp signature to generate a risk score. The risk score can represent the likelihood that the patient's prostate cancer will recur following radical prostatectomy.
H. Lee Moffitt Cancer Center And Research Institute, Inc.


 Diagnostic kit and method to diagnose incontinentia pigmenti patent thumbnailDiagnostic kit and method to diagnose incontinentia pigmenti
Diagnostic kit to diagnose incontinentia pigmenti (ip) (pigment incontinence) by means of which to make an analysis of a biological sample of a human organism to detect alterations in the nucleotide sequence of the ip locus. The diagnostic kit comprising primers for real time quantitative pcr analyses..
Consiglio Nazionale Delle Ricerche


 Methods and compositions for incorporating nucleotides patent thumbnailMethods and compositions for incorporating nucleotides
The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods.
Intelligent Bio-systems, Inc.


 Compositions and methods for nucleotide sequencing patent thumbnailCompositions and methods for nucleotide sequencing
The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either immovable or non-removable.
Illumina, Inc.


 Optimization of dna amplification reactions patent thumbnailOptimization of dna amplification reactions
The present invention relates to methods and uses where a combination of (i) an enzyme exhibiting 5′->3′ exonuclease activity and specifically degrading 5′-phosphorylated strands of double-stranded nucleic acids is used, and (ii) one or more primer pair(s), each primer being 5′ phosphorylated, in a method comprising at least a first and a second amplification reaction of a first and a second template, respectively, for preventing contamination of the second amplification reaction with amplification products of the first amplification reaction, as well as novel methods and kits using the combination. Also, the present invention relates to kits comprising the enzyme and either 5′-phosphorylated primers or a polynucleotide kinase..
Qiagen Gmbh


 Methods of using fet labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same patent thumbnailMethods of using fet labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same
Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is conducted in the presence of a polymerase having 3′→5′ exonuclease activity and at least one fet labeled oligonucleotide probe that includes a 3′→5′ exonuclease resistant quencher domain.
Life Technologies Corporation


 Corn event mon 87411 patent thumbnailCorn event mon 87411
The invention provides corn event mon 87411, and plants, plant cells, seeds, plant parts, and commodity products comprising event mon 87411. The invention also provides polynucleotides specific for event mon 87411 and plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides specific for event mon 87411.
Monsanto Technology Llc


Methods and compositions for selective regulation of protein expression

The invention provides novel recombinant dna molecules, compositions, and methods for selectively regulating the expression of a transcribable polynucleotide molecule or recombinant protein in a male reproductive tissue of a transgenic plant. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising such dna molecules and compositions..
Monsanto Technology Llc

Plants having increased tolerance to herbicides

The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of: providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-hppd) which is resistant or tolerant to a n-heterocyclyl-arylcarboxamide and/or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl transferase (mut-hst) which is resistant or tolerant to a n-heterocyclyl-arylcarboxamide, and applying to said site an effective amount of said herbicide. The invention further refers to a method of identifying a nucleotide sequence encoding a mut-hppd which is resistant or tolerant to a n-heterocyclyl-arylcarboxamide, as well as transgenic plants having increased resistance or tolerance to a n-heterocyclyl-arylcarboxamide as compared to a wild-type variety of the plant cell..
Basf Se

Method for improving crop productivity

Plants and plant cells derived therefrom are disclosed having one or more improved or introduced desirable traits such as increased plant biomass including both increased shoot and root growth and increased seed yield. Also disclosed is a method for the production of plants with increased cold tolerance, salt tolerance, drought tolerance, and resistance to parasitic plants.

Method for producing useful protein using plant

Provided is a method for producing a protein with a plant, comprising a step of infecting the plant with agrobacterium having a polynucleotide encoding a target protein, and a step of expressing the target protein in the plant by further cultivating the plant after infection, wherein production efficiency of the target protein is improved by imparting a damaging stimulus to the roots of the plant.. .
Mitsubishi Chemical Corporation

Chimeric and proline rich protein promoters for expression in plants

The present invention provides regulatory polynucleotide molecules isolated from plant proline rich protein genes and linked to a viral enhancer molecule. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the regulatory polynucleotide sequences, and methods for preparing and using the same..
Monsanto Technology Llc

Cpmv enhancer elements

An expression enhancer comprising a cpmv 5′utr nucleotide sequence consisting of x nucleotides (cmpvx), where x=160, 155, 150, or 114 of seq id no:1, or consisting of a nucleotide sequence comprising from about 80% to 100% sequence similarity with cmpvx, where x=160, 155, 150, or 114 of seq id no:1seq id no:1 is provided. The expression enhancer may further comprise a stuffer sequence fused to the 3′ end of the 5′utr nucleotide sequence (cmpvx+, where x=160, 155, 150, or 114 of seq id no:1).
Medicago Inc.

Selection in fungi

The present invention relates to methods for constructing a recombinant fungal host cell comprising one or more copies of a polynucleotide construct integrated in its genome, said method comprising transforming a fungal host cell with an integrative polynucleotide construct comprising a first polynucleotide encoding a selectable marker, wherein the first polynucleotide, a 5′ untranslated region thereof and/or a riboswitch operably linked therewith comprises a spliceosomal intron which has 5 nucleotides or less between its branch site and its acceptor site; and a second polynucleotide encoding a polypeptide of interest; as well as suitable polynucleotide constructs, resulting fungal host cells and methods of manufacture.. .
Novozymes A/s

Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters

A recombinantly expressed nucleotide triphosphate transporter efficiently imports the triphosphates of unnatural nucleotides into cells, and the endogenous cellular machinery incorporates those nucleotides into cellular nucleic acids. Ubps can therefore form within the cell's nucleic acids.
The Scripps Research Institute

Construct and sequence for enhanced gene expression

The invention relates to a method for transcription and expression using a nucleic acid construct which is characterized by the presence of a promoter followed by an intronic promoter. The invention further relates to said nucleic acid construct, an expression vector and a cell comprising said construct, and its use.
R1 B3 Holding B.v.

Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy

The current invention provides an improved oligonucleotide and its use for treating, ameliorating, preventing and/or delaying dmd or bmd.. .
Biomarin Technologies B.v.

Multivalent oligonucleotide assemblies

Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules. The double stranded oligonucleotide molecules include a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide..
City Of Hope

Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited

Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.. .
Pangu Biopharma Limited

Polypeptides having protease activity and polynucleotides encoding same

The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention further relates to the use of such polypeptides in detergent and/or in cleaning processes.
Novozymes A/s

Codon-optimized gene for mutated shrimp luciferase and use thereof

There has been a demand for a codon-optimized gene for the mutated catalytic domain of oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than that of native 19 kda protein.
Jnc Corporation

Polypeptides having peroxygenase activity and polynucleotides encoding same

The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s

Antibody constructs for egfrviii and cd3

The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human egfrviii on the surface of a target cell and a second binding domain which binds to human cd3 on the surface of a t cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector.
Amgen Research (munich)

Antibody constructs for msln and cd3

The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human msln on the surface of a target cell and a second binding domain which binds to human cd3 on the surface of a t cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector.
Amgen Inc.

Antigen binding constructs

The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain fc region of an antibody, wherein each epitope binding domain in capable of binding to vegf, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with vegf signalling, such as diabetic macular edema (dme), wet age-related macular degeneration (wet amd), diabetic retinopathy, retinal vein occlusion (rvo), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.. .
Glaxo Group Limited

Nucleotides for the treatment of liver cancer

Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.
Idenix Pharmaceuticals Llc





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This listing is a sample listing of patent applications related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.


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