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Nucleotide patents



      

This page is updated frequently with new Nucleotide-related patent applications.




Date/App# patent app List of recent Nucleotide-related patents
04/07/16
20160097101 
 Aptamer specific to colorectal cancer cell and application thereof patent thumbnailAptamer specific to colorectal cancer cell and application thereof
The present invention provides an aptamer specific to colorectal cancer cells and comprises a nucleotide sequence selected from the group consisting of seq id: no. 1 to seq id: no.
National Tsing Hua University


04/07/16
20160097100 
 Genetic test to predict patient response to bone morphogenetic protein in arthrodesis patent thumbnailGenetic test to predict patient response to bone morphogenetic protein in arthrodesis
The present invention provides a method of predicting an increased likelihood of a complication associated with administration of a bone morphogenetic protein (bmp) to a subject in need of a spinal fusion surgery by detecting single nucleotide polymorphisms (snps) in the subject. Also provided are methods of treatment with a bmp based on the presence or absence of snps and kits for use in detecting the snps..
Orthopaedic Associates Of Michigan


04/07/16
20160097097 
 Method for determining p1/p2 blood type and detection kit thereof patent thumbnailMethod for determining p1/p2 blood type and detection kit thereof
The present invention provides a method for determining p1/p2 blood type, including steps of providing a biological sample of a subject, detecting a genotype for single nucleotide polymorphism rs2143918 or rs5751348 in a4galt gene of the biological sample and determining a phenotype of the subject based on the genotype. Further, the present invention also provides a kit for determining p1/p2 blood type, including a primer pair for detecting a genotype for single nucleotide polymorphisms rs2143918 or rs5751348 in a4galt gene of a nucleic acid sample of a subject..

04/07/16
20160097093 
 Methods and processes for calling bases in sequence by incorporation methods patent thumbnailMethods and processes for calling bases in sequence by incorporation methods
Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof. .
Pacific Biosciences Of California, Inc.


04/07/16
20160097092 
 Polynucleotide mapping and sequencing patent thumbnailPolynucleotide mapping and sequencing
The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as dna or rna, linearizing the biopolymer in some cases, and determining the distance between the labels.
Bionano Genomics, Inc.


04/07/16
20160097091 
 Sequencing methods, compositions and systems patent thumbnailSequencing methods, compositions and systems
In some embodiments, the disclosure relates generally to methods, as well as compositions, systems, kits and apparatuses, for performing nucleotide incorporation, comprising: (a) providing a surface including one or more reaction sites containing a polymerase and a nucleic acid template that has, or is hybridized to, an extendible end; (b) performing a first nucleotide flow by contacting one or more of the reaction sites with a first solution including one or more types of terminator nucleotide; (c) incorporating at least one type of terminator nucleotide at the extendible end of the nucleic acid template contained within at least one of the reaction sites using the polymerase; and (d) detecting a non-optical signal indicating the nucleotide incorporation using a sensor that is attached or operatively linked to the at least one reaction site.. .
Life Technologies Gmbh


04/07/16
20160097083 
 Screening assay for identification of poly(adp-ribose) polymerase 1 inhibitors patent thumbnailScreening assay for identification of poly(adp-ribose) polymerase 1 inhibitors
Screening methods as well as systems and kits for identifying inhibitors of dna-independent, histone h4-dependent activation of parp-1 are provided. The methods comprise screening molecules for their capacity to inhibit the activation and/or biologic activity of parp-1, as measured by poly(adp)-ribose production from nicotinamide adenine dinucleotide.
Institute For Cancer Research D/b/a The Research Institute Of Fox Chase Cancer Center


04/07/16
20160097059 
 Enhanced expression and stability regions patent thumbnailEnhanced expression and stability regions
Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (eesyrs) are provided for expression of a gene of interest in a eukaryotic cell.
Regeneron Pharmaceuticals, Inc.


04/07/16
20160097058 
 Soy gene cluster regions and methods of use patent thumbnailSoy gene cluster regions and methods of use
Methods for conveying pathogen resistance into non-resistant soybean germplasm are provided. In some embodiments, the methods include introgressing pathogen resistance into a non-resistant soybean using one or more nucleic acid markers for marker-assisted breeding among soybean lines to be used in a soybean breeding program, wherein the markers are linked to and/or associated with pathogen resistance.
Syngenta Participations Ag


04/07/16
20160097056 
 Process of providing plants with abiotic stress resistance patent thumbnailProcess of providing plants with abiotic stress resistance
Crop growth management system comprising a process of providing a plant with improved abiotic stress tolerance, comprising providing aerial parts of said plant with a suspension containing cells of an agrobacterium strain comprising a nucleic acid molecule comprising a nucleic acid construct containing a nucleotide sequence of interest, said nucleotide sequence of interest providing said plant with increased abiotic stress tolerance upon expression in said plant.. .
Nomad Bioscience Gmbh


04/07/16
20160097054 

Root-preferred promoter and methods of use


The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter for the gene encoding sorghum bicolor tip2-3.
Pioneer Hi Bred International Inc


04/07/16
20160097051 

Methods and devices for in situ nucleic acid synthesis


Disclosed are compositions, methods and devices for the in situ synthesis of nucleic acids. In an exemplary embodiment, a support-bound oligonucleotide is elongated by addition of one or more nucleotides by hybridization of a partially double-stranded oligonucleotide, ligation and removal of unwanted nucleotides..
Gen9, Inc.


04/07/16
20160097041 

Enzymes


The invention relates to a nucleic acid polymerase capable of producing a non-dna nucleotide polymer from a dna nucleotide template, said polymerase comprising amino acid sequence having at least 36% identity to the amino acid sequence of seq id no:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of seq id no:1 at one or more residues of the thumb region, said residues selected from: amino acids 651 to 679 (patch 10a); wherein said amino acid sequence is mutated relative to the amino acid sequence of seq id no:1 at residue e664. In one embodiment said polymerase comprises the mutations y409g and e664k.
Medical Research Council


04/07/16
20160096160 

De novo synthesized gene libraries


De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein.
Twist Bioscience Corporation


04/07/16
20160095936 

Immunostimulatory compositions and methods of use thereof


Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide.
Massachusetts Institute Of Technology


04/07/16
20160095919 

Therapeutic agent for neurological disorder


Provided is a therapeutic agent for a neurological disorder directly acting on oxygen concentration-dependent vascular barrier breakdown. The therapeutic agent for a neurological disorder contains any one of (a) a functional nucleic acid against adam (a disintegrin and metalloproteinase)12 or adam17, (b) a functional nucleic acid expression vector containing a dna encoding the functional nucleic acid (a) and (c) a neutralizing antibody against adam12 or adam17, as an active ingredient.
Yamaguchi University


04/07/16
20160095918 

Rapid, efficient purification of hsv-specific t-lymphocytes and hsv antigens identified via same


A method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for t lymphocytes that are specific to a virus that attacks skin. Also provided are hsv antigens and epitopes that are useful for the prevention and treatment of hsv infection that have been identified via the methods of the invention.
University Of Washington


04/07/16
20160095916 

Induction of cross-reactive cellular response against rhinovirus antigens


The present invention concerns: a) an isolated peptide comprising an amino acid sequence which is at least 90% identical to the vp4 amino acid sequence of a rhinovirus, or an isolated polynucleotide comprising a nucleic acid sequence encoding said peptide, placed under the control of the elements necessary for its expression in a mammalian cell; and/or b) an isolated peptide comprising an amino acid sequence of at least 100 amino acids which is at least 90% identical to an amino acid sequence located in the last 363 c-terminal amino acids of the rna polymerase of a rhinovirus, or an isolated polynucleotide comprising a nucleic acid sequence encoding said peptide, placed under the control of the elements necessary for its expression in a mammalian cell; and c) a th1 adjuvant when said immunogenic composition comprises one or more of said isolated peptides.. .
Imperial Innovations Limited


03/31/16
20160090623 

Method for pairwise sequencing of target polynucleotides


The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template..
Illumina Cambridge Limited


03/31/16
20160090621 

Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis


This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.. .
The Trustees Of Columbia University In The City Of New York


03/31/16
20160090604 

Alfalfa plant and seed corresponding to transgenic event kk 179-2 and methods for detection thereof


The present invention provides a transgenic alfalfa event kk179-2. The invention also provides cells, plant parts, seeds, plants, commodity products related to the event, and dna molecules that are unique to the event and were created by the insertion of transgenic dna into the genome of a alfalfa plant.
Monsanto Technology Llc


03/31/16
20160090603 

Delivery platforms for the domestication of algae and plants


The present invention relates to a delivery platform that can be used to genetically modify a target in a plant or an alga. In one instance, polypeptides and/or polynucleotides can be delivered using silica delivery platforms, e.g., silica carriers or protocells.
Sandia Corporation


03/31/16
20160090599 

Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1


The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of delta-like (1) homolog (dlk1), in particular, by targeting natural antisense polynucleotides of delta-like (1) homolog (dlk1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression (dlk1)..
Curna, Inc.


03/31/16
20160090598 

Antisense compounds and uses thereof


The present disclosure provides compounds comprising modified oligonucleotides and anti-cd22 antibodies. Certain such modified oligonucleotides conjugated to anti-cd22 antibodies are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell.
Isis Pharmaceuticals, Inc.


03/31/16
20160090592 

De novo synthesized gene libraries


De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein.
Twist Bioscience Corporation


03/31/16
20160090591 

Oligonucleotide replacement for di-tagged and directional libraries


Transposomes and oligonucleotide replacement methods to make dna libraries that have distinct 5′ and 3′ tags, and to make directional libraries that are enriched for a desired strand.. .
Illumina, Inc.


03/31/16
20160090585 

Isomerases, nucleic acids encoding them and methods for making and using them


This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention..
Basf Enzymes Llc


03/31/16
20160090579 

Modified polymerases for improved incorporation of nucleotide analogues


Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same.. .
Illumina, Inc.


03/31/16
20160090578 

Enzymes catalyzing the glycosylation of polyphenols


D) is encoded by a nucleic acid hybridizing under stringent conditions with a nucleic acid complementary to a sequence with a nucleotide sequence of one of the sequences of seq id no: 1-6.. .

03/31/16
20160090577 

Heterologous expression of glycine n-acyltransferase proteins


The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a glycine n-acyltransferase protein (glyat, glyatl 1, glyatl 2, and glyatl 3) for the biosynthesis of n-acylglycine biosurfactants within a heterologous expression system.. .
Dow Agrosciences Llc


03/31/16
20160090414 

Binding proteins specific for insulin-like growth factors and uses thereof


Binding proteins, such as antibodies directed to igf-ii with cross-reactivity to igf-i and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the igf-ii with cross-reactivity to igf-i are disclosed.
Medimmune Limited


03/31/16
20160090407 

Interleukin-2 fusion proteins and uses thereof


The present invention generally relates to fusion proteins of immunoglobulins and interleukin-2 (il-2). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides.
Roche Glycart Ag


03/31/16
20160089651 

De novo synthesized gene libraries


De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein.
Twist Bioscience Corporation


03/24/16
20160085910 

Methods and systems for analyzing nucleic acid sequencing data


Method includes receiving sequencing data including a plurality of sample reads that have corresponding sequences of nucleotides and assigning the sample reads to designated loci. The method also includes analyzing the assigned reads for each designated locus to identify corresponding regions-of-interest (rois) within the assigned reads.
Illumina, Inc.


03/24/16
20160083805 

Methods and compositions for assessment of pulmonary function and disorders


The present invention provides methods for the assessment of risk of developing lung cancer in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing lung cancer, and the suitability of a subject for an intervention in respect of lung cancer.
Synergenz Bioscience Ltd


03/24/16
20160083789 

Nucleic acid sequencing with nanoscale electrode pairs


Sequencing methods, devices, and systems are described. Arrays of nanoscale electronic elements comprising two electrodes separated by an insulating layer are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the insulating region.
Pacific Biosciences Of California, Inc.


03/24/16
20160083788 

Method for targeted sequencing


The method of the present invention now provides a technique for generating sequence information from nucleic acid samples based on knowledge from part(s) of the nucleotide sequence. The knowledge of the partial sequence may include knowledge about the presence of restriction sites.
Keygene N.v.


03/24/16
20160083780 

Recombinase polymerase amplification


This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods.
Alere San Diego, Inc.


03/24/16
20160083761 

Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity, catalytic domains, carbohydrate binding modules and encoding the polypeptides, catalytic domains or carbohydrate binding modules. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules..
Novozymes A/s


03/24/16
20160083759 

Engineered ketoreductase polypeptides


The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Codexis, Inc.


03/24/16
20160083745 

Materials and increasing a plant's resistance to stress


Method of increasing resistance to a pathogen or a pest in a plant comprising introducing into the plant and expressing therein a polynucleotide comprising a nucleotide sequence encoding a qua-quine starch (qqs) polypeptide; method of producing a plant with increased resistance to a pathogen or a pest comprising crossing a plant obtained in accordance with the above method with a second plant to produce progeny plants and selecting progeny plants with increased resistance to a pathogen or a pest; a plant with increased resistance to a pathogen or a pest; a seed of the plant; a hybrid of the plant; and a seed of the hybrid plant.. .
Iowa State University Research Foundation, Inc.


03/24/16
20160083740 

Plant regulatory elements and uses thereof


The invention provides recombinant dna molecules and constructs, as well as their nucleotide sequences, useful for modulating gene expression in plants. The invention also provides transgenic plants, plant cells, plant parts, and seeds comprising a recombinant dna molecule comprising a dna molecule operably linked to heterologous transcribable dna molecule, as are methods of their use..
Monsanto Technology Llc


03/24/16
20160083729 

Phase changing formulations of nucleic acid payloads


The present invention is based, at least in part, upon discovery of a process for identifying phase changing peptides. Such phase changing peptides are capable of enhancing in vitro and in vivo delivery of oligonucleotides (e.g., dsrnas) in lipidic, vesicular, micellar and/or naked oligonucleotide formulations..
Dicerna Pharmaceuticals, Inc.


03/24/16
20160083726 

Compositions and methods for the treatment of parkinson disease by the selective delivery of oligonucleotide molecules to specific neuron types


The invention provides a conjugate comprising (i) a selectivity agent which binds specifically to one or more neurotransmitter transporters selected from the group consisting of a dopamine transporter (dat), serotonin transporter (sert) or a norepinephrine transporter (net) and (ii) a nucleic acid capable of specifically binding to a target molecule which is expressed in the same cell as the neurotransmitter transporter wherein said target molecule is α-synuclein or the mrna encoding α-synuclein. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interest and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes..
Nlife Therapeutics, S.l.


03/24/16
20160083721 

Multiplexed sequential ligation-based detection of genetic variants


The present invention provides multiplexed sequential ligation-based analysis of genetic variants in a mixed sample, including copy number variations and single nucleotide polymorphisms. The invention employs the techniques of sequential ligation and amplification..
Ariosa Diagnostics, Inc.


03/24/16
20160083718 

Expanded radix for polymeric tags


A method having steps of (a) providing nucleic acids having a tag sequence (n1)n(n2)n . .
Illumina, Inc.


03/24/16
20160083704 

Polypeptides having alpha amylase activity


The present invention relates to polypeptides having alpha-amylaseactivity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


03/24/16
20160083703 

Polypeptides having alpha amylase activity


The present invention relates to polypeptides having alpha-amylase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


03/24/16
20160083701 

Methods for modulating cyclic nucleotide-mediated signaling in cardiac myocytes and compositions


The invention provides a polypeptide possessing anti-hypertrophic activity in a cardiac myocyte, wherein the polypeptide is a mutant variant derived from wild-type pde3a1 protein and wherein the wild-type pde3a1 protein has the amino acid sequence given in seq id no:1 at amino acid position 146 to 1141.. .

03/24/16
20160083700 

Phytase


Polypeptides having phytase activity and polynucleotide sequences encoding the phytases are provided. The gene expresses the phytase at a level of at least 7 g/l to 40 g/l.
Basf Enzymes Llc


03/24/16
20160083441 

Development of protein-based biotherapeutics that penetrate cell-membrane and induce anti-cancer effect - cell-permeable trefoil factor 1 (cp-tff1) in gastrointestinal track (git) cancer, polynucleotides encoding the same, and anti-cancer compositions comprising the same


The present study investigated the use of macromolecule intracellular transduction technology (mitt) to deliver biologically active tff1 protein into gastric cancer cells both in vitro and in vivo. Proteins engineered to enter cancer cells are supposed to suppress cell proliferation and survival, consistent with its role as a tumor suppressor.
Cellivery Therapeutics, Inc.


03/24/16
20160083436 

Non-natural consensus albumin binding domains


Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.. .
Janssen Biotech, Inc.


03/24/16
20160083414 

Phosphoramidite building blocks for sugar-conjugated oligonucleotides


Novel nucleoside phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one phosphotriester linkage conjugated to a monosaccharide and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said building blocks, preferably followed by removal of protecting groups to provide monosaccharide-conjugated oligonucleotides..
Am Chemicals Llc


03/24/16
20160083407 

Nucleotide analogs


Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.. .
The Regents Of The University Of California


03/24/16
20160083353 

Small-molecule inhibitors targeting g-protein-coupled rho guanine nucleotide exchange factors


Provided are inhibitors of rho gtpase activation, and, in particular, compounds that inhibit rhoa activation by an rhogef. Also provided are related pharmaceutical compositions and methods.
University Of Cincinnati


03/24/16
20160082406 

Method for combinatorial particle manipulation for producing high-density molecule arrays, in particular peptide arrays, and molecule arrays that can be obtained by means thereof


The present invention relates to a method for combinatorial particle manipulation for producing high-density molecule arrays, and to the high-density molecule arrays obtained therefrom. In particular, the present invention relates to a method for producing high-density molecule arrays, in particular peptide or oligonucleotide arrays, by combinatorial patterning of particles, wherein the patterning is achieved by the selective and direct action of electromagnetic radiation..
Karlsruher Institut FÜr Technologie


03/24/16
20160082090 

Use of polysaccharides for promotion of enzymatic activity


This disclosure provides methods and compositions for the promotion of enzymatic activity of target enzymes, including but not limited to oligosaccharide/polysaccharide enzymes, protein enzymes, polynucleotide enzymes. The methods involve use of a non-naturally occurring polysaccharide (including but not limited hes) for promoting the enzymatic activity of an enzyme in liquid milieu, wherein the concentration of the polysaccharide in the composition comprising the target enzyme is from about 0.01% to about 55% w/v..
Genzyme Corporation


03/24/16
20160082081 

Methods and compositions for treating trinucleotide repeat disorders


Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.. .
Sangamo Biosciences, Inc.


03/24/16
20160082030 

D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease


Or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: pd, x, r1, r2, ra, and rb are as described herein.. .

03/24/16
20160081944 

Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same


Compositions for inhibiting oligonucleotide activity in vitro or in vivo to a cell that are formulated with at least one oligonucleotide encapsulated in a lipid nanoparticle, methods of making, and methods of using the same are disclosed.. .
Ohio State Innovation Foundation


03/24/16
20160081313 

Materials and methods for producing animals with short hair


The subject invention provides materials and methods for producing animals with short hair length. In a preferred embodiment, this is accomplished by altering in the animal the nucleotide sequence that encodes the prolactin receptor (prlr) protein such that a truncated version of the protein is produced.
Aggenetics, Inc.






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