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 Method to manage raw genomic data in a privacy preserving manner in a biobank patent thumbnailnew patent Method to manage raw genomic data in a privacy preserving manner in a biobank
A method to manage raw genomic data (sam/bam files) in a privacy preserving manner in a biobank. By using order preserving encryption of the reads' positions, the method provides a requested range of nucleotides to a medical unit, without revealing the locations of the short reads (which include the requested nucleotides) to the biobank.
Sophia Genetics S.a.


 Method for quantifying adeno-associated virus patent thumbnailnew patent Method for quantifying adeno-associated virus
A method for quantification of an adeno-associated virus genome, including the steps of (a) preparing a composition containing a sample, at least one primer pair for use in amplification of only a nucleotide sequence contained in inverted terminal repeats of an adeno-associated virus, and an intercalating dye; (b) performing nucleic acid amplification reaction using the composition prepared in the step (a); and (c) detecting an amplified product obtained in the step (b). The present invention is especially useful in the fields of medicine, gene engineering, and biology..
Takara Bio Inc.


 Method for determining snp genotype patent thumbnailnew patent Method for determining snp genotype
The present invention is generally drawn to a novel method for determining a snp (single nucleotide polymorphism) genotype using a pto-snv (probing and tagging oligonucleotide for single nucleotide variation). The present invention provides novel protocols for snp genotyping in which only one allele-specific oligonucleotide permits in a snp genotyping reaction to determine whether a target nucleic acid sequence to be analyzed is homozygous or heterozygous for the snp allele of interest or has no snp allele of interest..
Seegene, Inc.


 Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisene transcript to csf3 patent thumbnailnew patent Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisene transcript to csf3
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of colony-stimulating factor 3 (csf3), in particular, by targeting natural antisense polynucleotides of colony-stimulating factor 3 (csf3). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of csf3..
Curna, Inc.


 Photoinduced electron transfer (pet) primer for nucleic acid amplification patent thumbnailnew patent Photoinduced electron transfer (pet) primer for nucleic acid amplification
This application provides photoinduced electron transfer (pet) nucleic acid molecules that can be used detect and amplify nucleic acid molecules, such as target nucleic acid molecules. These pet tags can be attached to the 5′-end of a target sequence-specific primer, thereby generating a pet primer.
The Government Of The United States Of America As Represented By The Secretary Of The Department Of


 Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunnneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications patent thumbnailnew patent Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunnneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications
Techniques, methods, devices, and compositions are disclosed that are useful in identifying and sequencing natural and synthetic, and modified and unmodified dna, rna, pna, dna/rna nucleotides. The disclosed techniques, methods, devices, and compositions are useful in identifying various modifications, dna/rna damage, and nucleotide structure, using nanoelectronic quantum tunneling spectroscopy, which may be referred to as qm-seq.
Praan Biosciences, Inc.


 Processes for quantitative or qualitative detection of single-stranded or double-stranded nucleic acids patent thumbnailnew patent Processes for quantitative or qualitative detection of single-stranded or double-stranded nucleic acids
This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents.
Enzo Life Sciences, Inc.


 Stable nanoreporters patent thumbnailnew patent Stable nanoreporters
The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to improved, stable nanoreporter probes that are capable of binding to and identifying target molecules based on the probes' uniquely detectable signal.
Nanostring Technologies, Inc.


 Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same patent thumbnailnew patent Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
Ikeda Food Research Co., Ltd.


 Enone reductases patent thumbnailnew patent Enone reductases
The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations..
Codexis, Inc.


new patent

Design of rare-cutting endonucleases for efficient and specific targeting dna sequences comprising highly repetitive motives


The present invention is in the field of genetic editing tools and methods of genetic engineering. It relates to the engineering of rare-cutting endonucleases designed to contract highly repetitive motives in chromosomes, which are at the origin of certain genetic diseases, in particular the so-called “triplet repeat diseases”, such as the huntington disease.
Cellectis


new patent

Stem canker tolerant soybeans and methods of use


Soybean plants, germplasm and seed comprising at least one native locus conferring improved stem canker tolerance, molecular markers useful for identifying and, optionally, selecting soybean plants displaying tolerance, improved tolerance, or susceptibility to stem canker, and methods of their use are provided. Also provided are isolated polynucleotides, probes, kits, systems, and the like, useful for carrying out the methods described herein..
Pioneer Hi-bred International, Inc.


new patent

Manipulation of plasmodesmal connectivity to improve plant yield and fitness


Plants are provided that express a modified plasmodesmata localized protein 5 (pdlp5). The modified pdlp5 protein may modify plasmodesmal connectivity.
University Of Delaware


new patent

Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement


Recombinant polynucleotides and recombinant polypeptides useful for improvement of plants are provided. The disclosed recombinant polynucleotides and recombinant polypeptides find use in production of transgenic plants to produce plants having improved properties..
Monsanto Technology Llc


new patent

Resource use efficiency improvement in plants


Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased yield, increased resource use efficiency, increased water use efficiency, increased light use efficiency, increased photosynthetic capacity, increased photosynthetic rate, increased photosynthetic resource use efficiency, greater vigor, and/or greater biomass as compared to a control plant..
Mendel Biotechnology, Inc.


new patent

Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics


Provided are isolated polypeptides which are at least 80% homologous to seq id nos: 710-1153 and 9276-15726, isolated polynucleotides which are at least 80% identical to seq id nos: 1-709 and 1157-9275, nucleic acid constructs comprising same, transgenic cells expressing same, transgenic plants expressing same and method of using same for increasing yield, abiotic stress tolerance, growth rate, biomass, vigor, oil content, photosynthetic capacity, seed yield, fiber yield, fiber quality, fiber length, and/or nitrogen use efficiency of a plant.. .
Evogene Ltd.


new patent

Tobacco enzymes for regulating content of plant metabolites, and use thereof


The present invention provides a polynucleotide having a function of regulating a content of a plant metabolite, a polypeptide having a function of regulating a content of a plant metabolite, a vector containing the polynucleotide or a part of the polynucleotide, and a transformed plant produced by using the vector. Examples of such polynucleotides or polypeptides include polynucleotides or polypeptides with homology with quinolinate synthase or those which are predicted to be transcription factors.
Japan Tobacco Inc.


new patent

Tissue specific plant promoter and uses thereof


The present disclosure relates to plant genetic engineering and plant biology. In particular, the present disclosure relates to a polynucleotide fragment(s) with promoter activity that is plant male reproductive tissue specific..
Itc Limted


new patent

Compositions and methods containing a constitutive promoter to modify the expression of genes of interest in plants


The present invention relates to a new promoter of the expression of genes in plants. More specifically, the invention relates to regulatory sequences of polynucleotides that are isolated from soy plants and can initiate and activate polynucleotide transcription, and to the use of these regulatory sequences to modify the transcription of endogenous and/or heterologous polynucleotides and to produce polypeptides.
Empresa Brasileira De Pesquisa Agropecuária - Embrapa


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new patent

Compositions and methods for inhibiting jc virus (jcv)


The instant invention provides compositions and methods for inhibiting the jc virus (jcv), and that can be used, for example, for treating progressive multifocal leukoencephalopathy (pml). Antisense oligonucleotides are provided which are effective in inhibiting jcv replication or multiplication, alone or in a combination.
The U.s.a. As Represented By The Secretary, Dept. Of Health & Human Services


new patent

Methods and compositions employing an osteopontin aptamer to deliver nucleic acids into smooth muscle, endothelial, cardiac and progenitor/stem cells


Various therapeutic polynucleotides are provided along with their use to treat a variety of disease states. The chimeric polynucleotides disclosed herein comprise an opn aptamer linked to an opn-specific therapeutic oligonucleotide in order to deliver the opn-specific therapeutic polynucleotide to the site of opn expression.

new patent

Disulfide-containing alkyne linking agents


Described are improved disulfide-containing alkyne linking agents having have branched disulfides. The improved linking agents exhibit improved stability.
Arrowhead Madison Inc.


new patent

Rna interference agents


Described are rnai interference agents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to double stranded modified oligonucleotide molecules having blunt ends and a least one ribonucleotide near the 5′ end of a sense strand capable of mediating rna interference (rnai) against target nucleic acid sequences.
Arrowhead Madison Inc.


new patent

Nucleic acid amplification


In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for nucleic acid amplification. In some embodiments, methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions.
Life Technologies Corporation


new patent

Acyltransferases and uses thereof in fatty acid production


The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides.
Basf Plant Science Company Gmbh


new patent

Targeting tissue factor to activated platelets


The current invention relates to procoagulant fusion proteins, polynucleotides that encode said fusion proteins and cells that expresses said fusion proteins. Furthermore, the current invention relates to fusion proteins for use as a medicament.
Novo Nordisk A/s


new patent

Cdca1 epitope peptides and vaccines containing the same


Peptide vaccines against cancer are described herein. In particular, the present invention describes epitope peptides derived from cdca1 that elicit ctls.
Oncotherapy Science, Inc.


new patent

Novel reagents for universal site-specific labeling and modifications of nucleic acids


The present invention discloses a method of harnessing versatile phosphoramidation reactions to regioselectively incorporate alkynyl/azido groups into post-synthetic nucleic acids primed with phosphate at the 5′ termini. With and without the presence of copper, the modified nucleic acids were subjected to azide-alkyne cycloaddition to obtain various nucleic acid conjugates including a peptide-oligonucleotide conjugate (poc) with a high yield..
Kaohsiung Medical University


new patent

Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof to enhance skin permeation in treating skin conditions


Derivatives of nicotinic acid riboside (nar), nicotinamide riboside (nr), and reduced nar and nr, including 1-(2′,3′,5′-triacetyl-beta-d-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2′,3′,5′-triacetyl-beta-d-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more nr, nar, nrh, or narh derivatives, or prodrugs or salts thereof.
The Queen's University Of Belfast


new patent

Methods of treating heart failure with agonists of hypocretin receptor 2


Methods of treating individuals for heart failure are disclosed. In particular, the invention relates to methods of treating individuals for heart failure with agonists of hypocretin receptor 2.
The Board Of Trustees Of The Leland Stanford Junior University


new patent

D-alanine phosphoramide pronucleotides of 2'-methyl 2'-fluro guanosine nucleoside compounds for the treatment of hcv


Provided herein are compounds, compositions and methods for the treatment of flaviviridae infections, including hcv infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
Idenix Pharmacueticals, Llc


new patent

Anti-cancer compounds and methods for treating cancer


The present invention is directed to novel anti-cancer compounds and methods of treating and/or inhibiting cancer in patients, including metastatic cancer, recurrent cancer and drug resistant cancers, including multiple drug resistant cancers. Compounds according to the present invention provide anti-cancer activity, at least in part, by virtue of their nucleotide intercalating activity through the use of analogs of (−)lomaiviticin a, a potent anticancer agent which exhibits cytotoxicity through its principal mechanism of cleavage and to a lesser extent, its intercalation of cellular polynucleotides, especially dna.
Yale University


Methods and compositions of non-enzymatic amplification and direct detection of nucleic acids


The detection and quantification of nucleic acid sequences can be done using template catalyzed tara transfer reactions without enzyme and pcr. It comes with the novel chemistry platform technology using template assisted rapid assay (tara), an enzyme-free, pcr-less and rapid transfer reaction assay directly from samples from nasopharyngeal swab, nasal aspirate, oropharyngeal swab or blood.
Crosslife Technologies Inc.


Heterodimeric core-shell nanoparticle in which raman-active molecules are located at a binding portion of a nanoparticle heterodimer, use thereof, and preparing same


The present invention relates to a nanoparticle heterodimer in which raman-active molecules are located at a binding portion of the nanoparticle heterodimer, and more particularly, to a core-shell nanoparticle heterodimer comprising: a gold or silver core having a surface to which oligonucleotides are bonded; and a gold or silver shell covering the core. In addition, the present invention relates to the core-shell nanoparticle dimer, to a method for preparing same, and to the use thereof..
Seoul National University R&db Foundation


Copy number detection and methods


Described herein are methods of measuring, in a genomic sample from an individual, the relative frequency of a target sequence (that is, its copy number) with respect to a control sequence of known copy number at a different genomic locus in the same genome, wherein the target and control sequences differ by at least one single nucleotide variation (snv). These methods involve both the target sequence and the control sequence in a single reaction/container, using a pair of primers that prime amplification of both the target sequence and the control sequence, or a single downstream primer and two upstream primers (that differs only at the position of the snv between the target and control sequences), and measuring the abundance of each of the target sequence and the control sequence using snv-specific labeled probes or primers, or a melting curve analysis that distinguishes between the amplified control and target sequences.
The Board Of Trustees Of The University Of Illinois


Classification and actionability indices for lung cancer


The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant.
Life Technologies Corporation


Antipsychotic treatment based on snp genotype


The present invention relates to the prediction of antipsychotic treatment efficacy based on a patient's genotype at one or more single nucleotide polymorphism (snp) loci and to the treatment of a patient based on such prediction.. .
Vanda Pharmaceuticals, Inc.


Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms


Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise.
Duke University


Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods


This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analogue.. .
The Trustees Of Columbia University In The City Of New York


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Polymerase compositions and methods


Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions.
Life Technologies Corporation


Conjugates of biomolecules to nanoparticles


Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity.
Life Technologies Corporation


Duplicating dna with contiguity barcodes for genome and epigenome sequencing


Provided herein are methods and devices for accurate sequencing and detection of epigenetic information from template polynucleotides. Also provided are methods for long-range strand displacement amplification of polynucleotides, microfluidic devices with selectively permeable barriers for multistep processing, and methods for polynucleotide amplification using the microfluidic devices..
The Regents Of The University Of California


Buffer composition for hybridization use, and hybridization method


A buffer composition for hybridization of a target nucleic acid is provided. The nucleic acid can include a nucleotide to be detected with a nucleic acid probe.
Yamaguchi University


Methods for detecting nucleic acids


Disclosed herein are methods for detecting a target nucleic acid molecule in a sample. The methods can include contacting a sample with a detectably labeled probe (detection probe) that specifically binds to a first target sequence in the target nucleic acid molecule, a bifunctional oligonucleotide including a portion that specifically binds to a second target sequence in the target nucleic acid molecule and a portion that specifically binds to an anchor, and a surface comprising the anchor.
Htg Molecular Diagnostics, Inc.


Lactate dehydrogenase detector


A lactate dehydrogenase detector, which is used to detect a content of lactate dehydrogenase in a biological sample, comprises a substrate, an electrode assembly, a hydrophobic insulation layer, a cover and a reagent-containing membrane. The electrode assembly is disposed on the substrate and including a working electrode and a reference electrode.
Eumed Biotechnology Co., Ltd.


Novel glucose dehydrogenase


Provided is a flavin adenine dinucleotide-dependent glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 78% or more identity to the amino acid sequence of seq id no: 3, and having glucose dehydrogenase activity.. .
Toyobo Co., Ltd.


Engineered cleavage half-domains


Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence..
Sangamo Biosciences, Inc.


Engineering neural stem cells using homologous recombination


Described herein are recombinant polynucleotide-binding polypeptides, recombinant fusion proteins made with the described polynucleotide-binding polypeptides, methods of using the described recombinant polynucleotide-binding polypeptides and recombinant fusion proteins to modify genomic dna of cells and, in some embodiments, create recombinant cells. Methods are also provided herein for genetically modifying a neuronal stem cell.
The United States Of America, As Represented By The Secretary, Department Of Health & Human


Vector for nucleic acid insertion


The present invention provides the following: a vector for inserting a desired nucleic acid into a predetermined site of a nucleic acid comprising a region formed of a first nucleotide sequence, the predetermined site, and a region composed of a second nucleotide sequence, in the stated order in the 5′-to-3′ direction, wherein the vector comprises a region formed of the first nucleotide sequence, the desired nucleic acid, and the second nucleotide sequence in the stated order in the 5′-to-3′ direction; a kit that includes this vector; a method of inserting a nucleic acid comprising a step for introducing this vector into a cell; a cell acquired by this method; and an organism comprising this cell.. .
Hiroshima University


Msca1 nucleotide sequences impacting plant male fertility and using same


nucleotide sequences of a msca1 gene, critical to male fertility in plants are described, with dna molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified.
E I Du Pont De Nemours And Company


Drought tolerant plants and related constructs and methods


Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ring-h2 polypeptide..
Pioneer Hi-bred International, Inc.


Gene associated with non-biological stress resistance, and transformed plant


The present invention relates to a composition for enhancing non-biological stress resistance in plants and a composition for accelerating germination. A nucleotide sequence of the present invention is involved in the resistance against the drying stresses in plants, and a transformed plant in which the nucleotide sequence is overexpressed has prominent resistance against various kinds of non-biological stress, including drought stress.
Industry-academic Cooperation Foundation, Yonsei University


Soy nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement


Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources.
Monsanto Technology Llc


Methods and compositions for multiplex rna guided genome editing and other rna technologies


The invention includes materials and methods to generate numerous small rnas from one polynucleotide construct (synthetic gene) to facilitate rna-guided multiplex genome editing, modification, inhibition of expression and other rna-based technologies. The synthetic gene/polynucleotide construct encodes polycistronic rna components separated by trnas, and preferably also includes regulatory components such as a promoter or terminator to form an expression cassette.
The Penn State Research Foundation


Improved wound healing compositions and treatments


This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase..
Coda Therapeutics, Inc.


Modified nucleosides, nucleotides, and nucleic acids, and uses thereof


The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof.. .
Moderna Therapeutics, Inc.


Oligonucleotide comprising an inosine for treating dmd


The invention provides an oligonucleotide comprising an inosine, and/or a nucleotide containing a base able to form a wobble base pair or a functional equivalent thereof, wherein the oligonucleotide, or a functional equivalent thereof, comprises a sequence which is complementary to at least part of a dystrophin pre-m rna exon or at least part of a non-exon region of a dystrophin pre-m rna said part being a contiguous stretch comprising at least 8 nucleotides. The invention further provides the use of said oligonucleotide for preventing or treating dmd or bmd..
Biomarin Technologies B.v.


Enzymes having alpha amylase activity and methods of making and using them


The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided.
Basf Enzymes Llc


Transaminase biocatalysts


The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. .
Codexis, Inc.


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Biocatalysts and methods for the synthesis of armodafinil


The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(r)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (r)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess..
Codexis, Inc.


Inhibitors of complement activation


The invention relates to factor d inhibitors, which bind to factor d and block the functional activity of factor d in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like fab, f(ab′)2 and fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds.
Genentech, Inc.


Binding-triggered transcriptional switches and methods of use thereof


The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the binding-triggered transcriptional switch polypeptides, and host cells genetically modified with the nucleic acids. The present disclosure also provides chimeric notch receptor polypeptides, nucleic acids comprising nucleotide sequences encoding the chimeric notch receptor polypeptides, and host cells transduced and/or genetically modified with the nucleic acids.
The Regents Of The University Of California


Tslp binding proteins


The present disclosure relates to tslp binding proteins, such as anti-tslp single variable domains, polynucleotides encoding such tslp binding proteins, pharmaceutical compositions and kits comprising said tslp binding proteins and methods of manufacture. The present invention also concerns the use of such tslp binding proteins in the treatment of diseases associated tslp signaling, such as asthma..
Glaxosmithkline Intellectual Property Development Limited


Variant activin receptor


The present invention provides variant activin iib soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin a, myostatin, or gdf-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins.
Amgen Inc.


Nucleic acids and proteins from streptococcus groups a and b


The invention provides proteins from group b streptococcus (streptococcus agalactiae) and group a streptococcus (streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
J. Craig Venter Institute, Inc.


Polynucleotide molecules and uses thereof


The present disclosure provides alternative nucleosides, nucleotides, and polynucleotides, and methods of use thereof.. .
Moderna Therapeutics, Inc.


Massive parallel decoding dna and rna


This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of dna in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —oh group at the 3′-position of the deoxyribose..
The Trustees Of Columbia University In The City Of New York


Azido nucleosides and nucleotide analogs


Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
Alios Biopharma, Inc.






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This listing is a sample listing of patent applications related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.


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