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Nucleotide

Nucleotide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Novozymes A/s
May 24, 2018 - N°20180142312

The present invention relates to polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules..
NEW Methods and compositions for diagnosing or detecting lung cancers
The Wistar Institute Of Anatomy And Biology
May 24, 2018 - N°20180142303

A multi-analyte composition for the diagnosis of lung cancer or lung disease comprises a ligand selected from a nucleic acid sequence, polynucleotide or oligonucleotide capable of specifically complexing with, hybridizing to, or identifying an mrna gene transcript from a mammalian blood sample, and an additional ligand selected from a nucleic acid sequence, polynucleotide or oligonucleotide capable of specifically complexing with, ...
NEW Prediction of therapeutic response in inflammatory conditions
Blueprint Bio, Inc.
May 24, 2018 - N°20180142301

Response to treatment of an inflammatory condition can be predicted based on characteristics of one or more markers from a subject. The markers can include expressions of nucleotide sequences identified herein and of combinations thereof.
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NEW Methods and systems for processing polynucleotides
10x Genomics, Inc.
May 24, 2018 - N°20180142292

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing..
NEW Blocking oligonucleotides
May 24, 2018 - N°20180142290

A blocking oligonucleotide (10, 10a, 10a′, 10a″, 10b, 10c, 10d, 10e) comprises a 3′-end complementary sequence (13) complementary to a 3′-end sequence (23) of a globin mrna molecule (20; 20a, 20b) and a poly-a complementary sequence (12) of at least one nucleotide complementary to at least a portion of a poly-a sequence (22) of the globin mrna molecule (20, 20a, 20b). The blocking ...
NEW Polynucleotide libraries having controlled stoichiometry and synthesis thereof
Twist Bioscience Corporation
May 24, 2018 - N°20180142289

Provided herein are compositions, methods and systems relating to libraries of polynucleotides having preselected stoichiometry with regard to species of polynucleotides such that the libraries allow for predetermined application outcomes, e.g., controlled representation after amplification and uniform enrichment after binding to target sequences. Further provided herein are polynucleotide probes and applications thereof for uniform and accurate next generation sequencing..
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NEW Crispr hybrid dna/rna polynucleotides and methods of use
Pioneer Hi-bred International. Inc.
May 24, 2018 - N°20180142263

The present disclosure provides dna-guided crispr systems; polynucleotides comprising dna, rna and mixtures thereof for use with crispr systems; and methods of use involving such polynucleotides and dna-guided crispr systems.. .
NEW Promoters for expression of heterologous genes
The Sydney Children's Hospitals Network (randwick And Westmead) (incorporating The Royal Alexandra
May 24, 2018 - N°20180142260

The present disclosure relates generally to promoters derived from the aav anti-sense strand, their use in the expression of one or more heterologous coding sequences, and isolated polynucleotides, vectors and recombinant viruses comprising the promoters. The present disclosure also relates to enhancers derived from the aav anti-sense strand, their use in increasing the expression of one or more heterologous coding ...
NEW Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency of ...
Evogene Ltd.
May 24, 2018 - N°20180142252

Provided are isolated polypeptides which are at least 80% homologous to seq id nos: 202-219, 221-292, 295-327, 4064-4175, 4177-4210, 4212-4580, 4582-4603, 4605-4749, 4751-4778, 4780-5223, 5225-5493, 5522-5807, 5812, 5815-5816, 5828-6679, 6689-6690, 6708-6785, 6792-6892 or 6893, isolated polynucleotides which are at least 80% identical to seq id nos: 1-91, 94-201, 328-2317, 2320-2321, 2323, 2326-3835, 3838-3840, 3842-3843, 3848, 3850-3852, 3854, 3856-3953, 3955-4061 or 4062, nucleic acid constructs comprising same, transgenic cells ...
NEW Single-stranded oligonucleotides for use in the medical treatment of skin disorders
May 24, 2018 - N°20180142246

The invention relates to non-cpg single-stranded oligonucleotides (ssons) for use in the treatment or prophylaxis of disorders of the skin and/or subcutaneous tissue, including pruritus, in a suitable formulation or in combination with other immunomodulatory treatments. The said ssons have a length of at least 25 nucleotides and are stabilized by phosphorothioate internucleotide linkages and/or 2′-o-methyl modifications..
NEW Methods and compositions for the specific inhibition of gene expression by double-stranded rna
Integrated Dna Technologies, Inc.
May 24, 2018 - N°20180142241

The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded rna (“dsrna”), and methods for preparing ...
NEW Oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and application thereof
Nanjing Keygen Biotech Co., Ltd.
May 24, 2018 - N°20180142238

The present invention provides an oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and an application thereof. The core sequence of the oligodeoxy nucleotide is ttysggaawt, wherein y is c or t; s is c or g; and w is a or t.
NEW Surface anchored light chain bait antibody display system
Merck Sharp & Dohme Corp.
May 24, 2018 - N°20180142233

The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction ...
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  • 1871+ full patent PDF documents of Nucleotide-related inventions.
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NEW Alpha-amylase variants having improved performance and stability
Novozymes A/s
May 24, 2018 - N°20180142224

The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
NEW Compositions and methods comprising sequences having meganuclease activity
Pioneer Hi-bred International, Inc.
May 24, 2018 - N°20180142223

Compositions and methods comprising polynucleotides and polypeptides having meganuclease activity are provided. Further provided are nucleic acid constructs, yeast, plants, plant cells, explants, seeds and grain having the meganuclease sequences.
NEW Mutant interleukin-2 polypeptides
Roche Glycart Ag
May 24, 2018 - N°20180142037

The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the il-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant il-2 polypeptides, polynucleotide molecules encoding the mutant il-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules.
NEW Bispecific antibody constructs for cdh3 and cd3
Amgen Research (munich) Gmbh
May 24, 2018 - N°20180142021

The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human cdh3 on the surface of a target cell and a second binding domain which binds to human cds on the surface of a t cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and ...
NEW Anti-ror1 antibodies
Eureka Therapeutics, Inc.
May 24, 2018 - N°20180142016

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for receptor tyrosine kinase-like orphan receptors (ror), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules.
NEW Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
Corixa Corporation
May 24, 2018 - N°20180142001

Compositions and methods for the therapy and diagnosis of inflammatory bowel disease (ibd), including crohn's disease and ulcerative colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and t cells that are specific for cells expressing such polypeptides.
NEW Novel recombinant bi-functional fusion protein and preparation and application therefor
Immuneonco Biopharmaceuticals (shanghai) Co.,ltd
May 24, 2018 - N°20180141986

The present invention provides a recombinant fusion protein containing a first extracellular ig-like domain of a signal-regulator protein alpha (sirpα), linked to an fc fragment of a human igg1. The present invention also provides a polynucleotide encoding the recombinant fusion protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for ...
NEW Process using dual specificity oligonucleotide and dual specificity oligonucleotide
Seegene, Inc.
May 24, 2018 - N°20180141970

The present invention relates to various processes by a template-dependent extension reaction using a dual specificity oligonucleotide and a dual specificity oligonucleotide composed of three different tm portions therefor. Demonstrated in the present invention are the features of the dual specificity oligonucleotide, which are high hybridization specificity and mismatch tolerance..
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