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Nucleotide patents



      
           
This page is updated frequently with new Nucleotide-related patents. Subscribe to the Nucleotide RSS feed to automatically get the update: related Nucleotide RSS feeds.

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Date/App# patent app List of recent Nucleotide-related patents
04/17/14
20140109259
 Guard cell promoters and uses thereof patent thumbnailGuard cell promoters and uses thereof
Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences encompassing a guard-cell-preferred promoter which drives preferential expression of gene products in guard cells.
04/17/14
20140109250
 Transgenic maize event mon 87427 and the relative development scale patent thumbnailTransgenic maize event mon 87427 and the relative development scale
The invention provides transgenic maize event mon 87427 and plants, plant cells, seeds, plant parts, and commodity products derived from event mon 87427. The invention also provides nucleotides specific for transgenic maize event mon 87427 and plants, plant cells, seeds, plant parts, and commodity products comprising nucleotides specific for transgenic maize event mon 87427.
04/17/14
20140108411
 Computer algorithm for automatic allele determination from fluorometer genotyping device patent thumbnailComputer algorithm for automatic allele determination from fluorometer genotyping device
The present invention provides methods and systems for an automated method of identifying allele values from data files derived from processed fluorophore emissions detected during the observation of fluorophore labeled nucleotide probes used in analyzing polymorphic dna are provided. These methods are used in the rapid and efficient distinguishing of targeted polymorphic dna sites without control samples..
04/17/14
20140107983
 Systems and methods of designing nucleic acids that form predetermined secondary structure patent thumbnailSystems and methods of designing nucleic acids that form predetermined secondary structure
Described is a system and process for designing the equilibrium base-pairing properties of a test tube of interacting nucleic acid strands. A target test tube is specified as a set of desired ‘on-target’ complexes, each with a target secondary structure and target concentration, and a set of undesired ‘off-target’ complexes, each with vanishing target concentration.
04/17/14
20140107938
 Information processing system using nucleotide sequence-related information patent thumbnailInformation processing system using nucleotide sequence-related information
Further, the present invention includes steps a and b. Step a is performed to acquire either encrypted nucleotide sequence-related information or cryptographic key that corresponds to positional information indicating a position within a nucleotide sequence.
04/17/14
20140107330
 Oligomeric compounds comprising bicyclic nucleotides and uses thereof patent thumbnailOligomeric compounds comprising bicyclic nucleotides and uses thereof
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell.
04/17/14
20140107191
 Method for enhanced uptake of viral vectors in the myocardium patent thumbnailMethod for enhanced uptake of viral vectors in the myocardium
The present invention relates to improved therapies for the treatment of heart disease, particularly the improved delivery of therapeutic agents to heart tissue by direct infusion into the coronary circulation. A preferred embodiment of the invention is a method of treating or preventing a cardiovascular disease by transfecting cardiac cells of a large mammal, the method comprising, identifying a mammal in need of treatment or prevention of heart disease, supplying no to the coronary circulation prior to, and/or during the infusion of a therapeutic polynucleotide into a blood vessel of the coronary circulation in vivo, where the therapeutic polynucleotide is infused into the blood vessel over a period of at least about three minutes, where the coronary circulation is not isolated or substantially isolated from the systemic circulation of the mammal; and where the therapeutic polynucleotide transfects cardiac cells of the animal resulting in the treatment or prevention of the heart disease..
04/17/14
20140107190
 Highly inducible dual-promoter lentiviral tet-on system patent thumbnailHighly inducible dual-promoter lentiviral tet-on system
The invention relates to expression systems useful for regulated expression of a gene of interest based on the constitutive expression of the original tetr repressor and the expression of the polynucleotide driven by a constitutive promoter operably linked to an operator sequence for a tetracycline operator sequence. The system can be provided as two different polynucleotides or as an all-in-one vector.
04/17/14
20140107189
 Modified polynucleotides encoding apoptosis inducing factor 1 patent thumbnailModified polynucleotides encoding apoptosis inducing factor 1
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmrna molecules.. .
04/17/14
20140107186
 Capsid-free aav vectors, compositions, and methods for vector production and gene delivery patent thumbnailCapsid-free aav vectors, compositions, and methods for vector production and gene delivery
An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (aav) inverted terminal repeat (itr), a nucleotide sequence of interest and a second aav itr, wherein said nucleic acid molecule is devoid of aav capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response.
04/17/14
20140107182
Synthetic mimics of mir-34
Embodiments concern methods and compositions involving mir-34 mimics, including mir-34a and mir-34c mimics. In some embodiments, there are double-stranded rna molecules with modified nucleotides having an active strand with a mir-34a sequence and a complementary passenger strand.
04/17/14
20140107177
Methods and compositions for transdermal delivery of nucleotides
The present invention relates to formulations and related methods for transdermal delivery of nucleic acids. Specifically, the invention relates to a formulation containing lipids and an alcohol and which is capable of providing effective transdermal delivery of nucleic acid.
04/17/14
20140107020
Fibronectin based scaffold domain proteins that bind to myostatin
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic kidney disease, heart failure, myocardial infarction, and fibrosis.
04/17/14
20140106983
Methods for detecting and measuring specific nucleic acid sequences
The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention.
04/17/14
20140106450
Compositions and methods for inhibiting expression of a target gene
The present invention relates to a double-stranded ribonucleic acid (dsrna) having a nucleotide sequence which is substantially identical to at least a part of a target gene and which is no more than 49, preferably less than 25, nucleotides in length, and which comprises a complementary (antisense) rna strand having a 1 to 4 nucleotide overhang at the 3′-end and a blunt 5′-end. The invention further relates to a pharmaceutical composition comprising the dsrna and a pharmaceutically acceptable carrier.
04/17/14
20140106433
Rnase h-based assays utilizing modified rna monomers
The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide.
04/17/14
20140106416
Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the plastids of transgenic plants and microalgae, (2) create novel antibiotic resistant transgenic plants and microalgae, and (3) create a novel selection system and/or targeting sites for mediating the insertion of genetic material into plant and microalgae plastids. The specific polynucleotides to be used, solely or in any combination thereof, are publicly available from genebank and contain open reading frames having sequences that upon expression will produce active proteins with the following enzyme activities: (a) acetoacetyl coa thiolase (ec 2.3.1.9), (b) 3-hydroxy-3-methylglutaryl-coenzyme a (hmg-coa) synthase (ec 4.1.3.5), (c) hmg-coa reductase (ec 1.1.1.34), (d) mevalonate kinase (ec 2.7.1.36), (e) phosphomevalonate kinase (ec 2.7.4.2), (f) mevalonate diphosphate decarboxylase (ec 4.1.1.33), (g) isopentenyl diphosphate (ipp) isomerase (ec 5.3.3.2), and (h) phytoene synthase (ec 2.5.1.32)..
04/17/14
20140106410
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/17/14
20140106409
Chimeric alpha-amylase variants
Chimeric alpha-amylases having the characteristics of high thermostability and good performance in starch degradation, especially high-temperature liquefaction processes, are provided. The alpha-amylases are chimeras of amyl and amys enzymes, and are useful in starch degradation processes.
04/17/14
20140106401
Selection of host cells expressing protein at high levels
Described is a dna molecule comprising an open reading frame sequence encoding a selectable marker polypeptide, wherein the dna molecule in the coding strand comprises a translation start sequence for the selectable marker polypeptide having a gtg or ttg start codon, and wherein the orf sequence that encodes the selectable marker protein has been mutated to replace at least half of its cpg dinucleotides as compared to the native orf sequence that encodes the selectable marker protein. Further provided are such dna molecules wherein the orf sequence that encodes a selectable marker polypeptide is part of a multicistronic transcription unit that further comprises an open reading frame sequence encoding a polypeptide of interest.
04/17/14
20140106400
Polypeptides having carboxypeptidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having carboxypeptidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/17/14
20140106398
Vector-host system
The present invention relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell is a filamentous fungal cell. The invention also relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell comprises a recombinant polynucleotide construct comprising a polynucleotide encoding a biological compound of interest or a compound involved in the synthesis of a biological compound of interest..
04/17/14
20140106360
Methods and apparatus to sequence a nucleic acid
Methods, systems, apparatus and machine readable media are disclosed to sequence nucleic acid. An example method includes subjecting a sequence of target nucleotide bases captured on a microtransponder to a plurality of sequencing reactions to build a sequence of labeled nucleotide bases that are complementary to and bound to the sequence of target nucleotide bases.
04/17/14
20140106352
Novel genes causing hereditary kidney disease or malformation of the urinary tract
Isolated nucleotides encoding polypeptides with mutations leading to amino acid substitutions linked to hereditary kidney disease or malformation of the urinary tract are provided herein. Constructs, cells, probes and inhibitory molecules comprising these mutations are also provided and may be used in screening assays for candidate agents to treat or reverse these diseases or alternatively to provide diagnostic tests.
04/17/14
20140106350
Compositions, methods and related uses for cleaving modified dna
Compositions, methods and related uses are provided relating to cleaving modified dna. For example, a set of dna fragments obtainable by enzymatic cleavage of a large dna is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide.
04/17/14
20140106335
Oligonucleotide probe for the detection of adenovirus
The present invention relates to an oligonucleotide probe for the detection of adenoviral nucleic acid in a biological sample. In a further aspect, the invention relates to a method for the detection of an adenoviral nucleic acid in a biological sample.
04/17/14
20140106030
Probiotics with enhanced survival properties
The present invention relates to a method for screening for a bacterium exhibiting enhanced survival properties in the gastro-intestinal tract. The present invention further relates to a method for screening for culture conditions that provide a bacterium exhibiting enhanced survival properties in the gastro-intestinal tract.
04/17/14
20140105966
Modified polynucleotides encoding hepatitis a virus cellular receptor 2
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
04/17/14
20140105965
Modified polynucleotides encoding copper metabolism (murr1) domain containing 1
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
04/17/14
20140105964
Modified polynucleotides encoding aquaporin-5
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
04/17/14
20140105905
High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies
The present embodiments are related to high-affinity antibodies directed to il-8, methods of making and characterizing such antibodies and uses of such antibodies. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (fr's) and/or complementarity determining regions (cdr's), are provided..
04/17/14
20140105898
Apoptosis-inducing molecules and uses therefor
This invention relates generally to methods and agents for modulating adiposity-related conditions. More particularly, the present invention relates to the use of trail death receptor agonists, including nucleic acids such as trail polynucleotides, peptides and polypeptides including trail polypeptides, trail dr agonist antigen-binding molecules, trail dr peptide agonists as well as small molecule trail dr agonists in compositions and methods for treating or preventing adiposity-related conditions such as obesity, diabetes mellitus and metabolic syndrome..
04/17/14
20140105896
Fibronectin based scaffold domain proteins that bind to myostatin
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic kidney disease, heart failure, myocardial infarction, and fibrosis.
04/17/14
20140102915
Electrochemical proximity assay
The present disclosure includes an electrochemical proximity assay (ecpa) which leverages two aptamer or antibody-oligonucleotide probes and proximity-dependent dna hybridization to move a redox active molecule near an electrically conductive base. The ecpa of the present disclosure produces rapid, quantitative results, enabling point-of-care use in the detection of biomarkers of disease..
04/10/14
20140101793
Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
04/10/14
20140101791
Resistance genes
The present invention relates to polynucleotides encoding adult plant pathogen resistance proteins. Also provided are transgenic plants expressing these polynucleotides to enhance the resistance of the plants to pathogens..
04/10/14
20140100790
Information processing system using nucleotide sequence-related information
A system for processing information for providing semantic information and/or information associated with the semantic information useful for each individual organism through effective utilization of differences in nucleotide sequence-related information among individual organisms is constructed. The method for processing information on a nucleotide sequence comprises: (a) receiving request information for an object and/or service; (b) obtaining positional information in accordance with the request information from a memory having positional information representing a position in a nucleotide sequence memorized therein; and (c) obtaining nucleotide sequence-related information corresponding to the positional information obtained in (b) above, and obtaining semantic information implied by the nucleotide sequence-related information and/or information associated with the semantic information..
04/10/14
20140100263
Methods for treatment of alport syndrome
Provided herein are methods for the treatment of alport syndrome, using modified oligonucleotides targeted to mir-21. In certain embodiments, a modified oligonucleotide targeted to mir-21 improves kidney function and/or reduces fibrosis in subjects having alport syndrome.
04/10/14
20140100261
Trpm-2 antisense therapy
A method for treating an individual suffering from a cancer comprising administering to the individual a chemotherapeutic agent, and ii) one antisense oligonucleotide having nucleotides in the sequence set forth in seq. Id no.
04/10/14
20140100186
Method to improve antiviral activity of nucleotide analogue drugs
A method of modifying a nucleotide or a nucleotide analogue to increase its overall effectiveness in treating an antiviral disease is provided. In some cases, a compound comprising a base, sugar, phosphonate moiety, and amino acid residue is provided, where the base-sugar may be a nucleoside, and the amino acid residue may be a tyrosine residue.
04/10/14
20140100160
Novel use of c-terminal domain of igfbp-5 comprising heparin-binding domain as an angiogenesis inhibitor
The present invention relates to a pharmaceutical composition for inhibiting angiogenesis comprising an isolated peptide comprising the heparin-binding domain of insulin-like growth factor-binding protein-5 (igfbp-5), a method for inhibiting angiogenesis using the peptide, a pharmaceutical composition for the prevention or treatment of cancer comprising the peptide, a method for treating cancer using the peptide, a novel angiogenesis-inhibiting peptide derived from heparin-binding domain of igfbp-5, a polynucleotide encoding the peptide, an expression vector comprising the polynucleotide and a transformant comprising the vector.. .
04/10/14
20140100135
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase.
04/10/14
20140100110
Soybean event dp-305423-1 and compositions and methods for the identification and/or detection thereor
Compositions and methods related to transgenic high oleic acid/als inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides soybean plants having a dp-305423-1 event which imparts a high oleic acid phenotype and tolerance to at least one als-inhibiting herbicide.


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This listing is a sample listing of patents related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.
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