Popular terms

Follow us on Twitter
twitter icon@FreshPatents

Web & Computing
Cloud Computing
Ecommerce
Search patents
Smartphone patents
Social Media patents
Video patents
Website patents
Web Server
Android patents
Copyright patents
Database patents
Programming patents
Wearable Computing
Webcam patents

Web Companies
Apple patents
Google patents
Adobe patents
Ebay patents
Oracle patents
Yahoo patents

[SEARCH]

Nucleotide patents

      

This page is updated frequently with new Nucleotide-related patent applications.




Date/App# patent app List of recent Nucleotide-related patents
08/18/16
20160238611 
 Non-ribosomal protein synthesis pigment fusion peptides patent thumbnailNon-ribosomal protein synthesis pigment fusion peptides
The present invention relates to a polypeptide or polypeptide complex, comprising at least one non-ribosomal peptide synthesis (nrps) amino acid module functionally connected to at least one pigment module. The present invention further relates to a labeled oligopeptide comprising a non-naturally attached nrps pigment or/and polyketide pigment, to a polynucleotide encoding a fusion polypeptide, a vector, preferably an expression vector, comprising the polynucleotide of the present invention and to a host cell comprising the polypeptide or polypeptide complex and/or the polynucleotide, and/or the vector according to the present invention.
Ruprecht-karls-universität Heidelberg


08/18/16
20160238608 
 Human cancer-related gene, its encoded products and applications patent thumbnailHuman cancer-related gene, its encoded products and applications
The invention discloses a human cancer-related gene, laptm4b, its encoded products and their applications thereof. This human cancer-related gene provided by this invention comprises one of the following nucleotide sequences: (1) seq id no: 1, seq id no: 2, seq id no: 3, seq id no: 6, or seq id no: 8 in the sequence listings; (2) polynucleotides that encode the protein sequences of seq id no: 4, seq id no: 5, or seq id no: 7 in the sequence listings; (3) dna sequences having above 90% homology with the dna sequences specified by seq id no: 1, seq id no: 2, seq id no: 3, seq id no: 6, or seq id no: 8 in the sequence listings, and these dna sequences encode the proteins with the same or similar functions.
Peking University


08/18/16
20160237510 
 Genetic loci associated with resistance of soybean to cyst nematode and methods of use patent thumbnailGenetic loci associated with resistance of soybean to cyst nematode and methods of use
Various compositions and methods are provided for identifying and selecting plants with enhanced resistance to soybean cyst nematode (scn). Further provided are transgenic plants, plant parts, and seed and methods of their use comprising a heterologous polynucleotide operably linked to a promoter active in the plant are provided, as are methods of making such plants and methods of use, wherein said heterologous polynucleotide comprises at least one, or any combination thereof, of glyma18g2580, glyma18g2590, glyma18g2600, glyma18g2610; and glyma18g2570 or an active variant or fragment thereof.
Pioneer Hi Bred International Inc


08/18/16
20160237492 
 Diagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss) patent thumbnailDiagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss)
The present invention relates to the fields of neurological and skin disorders. More specifically, the present invention provides methods and compositions for diagnosing and prognosing sturge-weber syndrome (sws), klippel-trenaunay-weber syndrome (ktws), and port wine stains (pws).
Duke University


08/18/16
20160237486 
 Native-extension parallel sequencing patent thumbnailNative-extension parallel sequencing
The present invention provides methods for native extension parallel sequencing of polynucleotide.. .
Centrillion Technology Holdings Corporation


08/18/16
20160237481 
 Mutation analysis patent thumbnailMutation analysis
A method and an oligonucleotide probe are described for determining the presence or absence of mutant alleles in a genomic locus. The probe binds to different alleles of a target sequence with different melting temperatures (tm).
Epistem Limited


08/18/16
20160237479 
 Methods and compositions for isothermal amplification and detection of mycoplasma pneumoniae patent thumbnailMethods and compositions for isothermal amplification and detection of mycoplasma pneumoniae
Disclosed herein are methods and compositions (e.g., oligonucleotide primers) for isothermal amplification and detection of m. Pneumoniae nucleic acids in a sample.
P3s Corporation.


08/18/16
20160237478 
 Method, kits and materials for detection of lyme disease borrelia sp. infection patent thumbnailMethod, kits and materials for detection of lyme disease borrelia sp. infection
Disclosed herein are method, materials and kits for detection of b. Burgdorferi infection or determining stage of lyme disease in a subject.
University Of Central Florida Research Foundation, Inc.


08/18/16
20160237454 
 Non-silencing selectable marker genes and methods of use patent thumbnailNon-silencing selectable marker genes and methods of use
Provided are nucleic acids and expression vectors having a non-silencing selectable marker gene, and methods of using the same. A subject expression vector includes an expression cassette and a non-silencing selectable marker gene.
The Board Of Trustees Of The Leland Stanford Junior University


08/18/16
20160237445 
 Soybean pip1 promoter and its use in constitutive expression of transgenic genes in plants patent thumbnailSoybean pip1 promoter and its use in constitutive expression of transgenic genes in plants
The disclosure relates to gene expression regulatory sequences from soybean, specifically to recombinant dna constructs comprising the promoter of a soybean plasma membrane intrinsic protein gene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same..
E. I. Du Pont De Nemours And Company


08/18/16
20160237439 

Modular rna regulators and methods


This disclosure describes modular mirna regulator molecules and methods of using modular mirna regulator molecules. Generally, the modular mirna regulator molecules include a recognition module and an inhibition module.
Stc.unm


08/18/16
20160237434 

Modulation of apolipoprotein c-iii expression


Compounds, compositions and methods are provided for modulating the expression of apolipoprotein c-iii. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein c-iii.
Ionis Pharmaceuticals, Inc.


08/18/16
20160237426 

Peptide oligonucleotide conjugates


Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects..
Sarepta Therapeutics, Inc.


08/18/16
20160237417 

Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes A/s


08/18/16
20160237416 

Polypeptides having cellobiohydrolase activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


08/18/16
20160237168 

Methods for treating and preventing multiple sclerosis


We have discovered that lrg-47 (also called p47 gtpase), plays a central role in the pathogenesis of multiple sclerosis, and that inhibition of lrg-47 activity by anti-lrg-47 antibodies or of lrg-47 expression by sirna dramatically reduce the pathology and symptoms of multiple sclerosis. Certain embodiments of the invention are directed to the therapeutic use of anti-lrg-47 antibodies (mouse or rabbit or other antibodies that are humanized or human antibodies to lrg-47, preferably antibodies made against human lrg-47) or sirna or antisense nucleotides that specifically hybridize with the gene or mrna or cdna encoding human lrg-47 to treat or prevent multiple sclerosis and other autoimmune diseases that are t-cell-mediated.
The Trustees Of Columbia University In The City Of New York


08/18/16
20160237155 

Targeted/immunomodulatory fusion proteins and methods for making same


The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy, and more specifically, to nucleotide sequences encoding the fusion proteins, wherein the chimeric fusion proteins comprises at least one targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.. .
Biocon Limited


08/18/16
20160237154 

Antibody therapeutics that bind ctla4


There is disclosed compositions and methods relating to or derived from anti-ctla4 antibodies. More specifically, there is disclosed fully human antibodies that bind ctla4, ctla4-antibody binding fragments and derivatives of such antibodies, and ctla4-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


08/18/16
20160237134 

Alternative nucleic acid molecules containing reduced uracil content and uses thereof


The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mrna wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response.
Moderna Therapeutics, Inc.


08/18/16
20160237127 

Recombinant peptide vaccines against ticks, and nucleotide sequences coding for the recombinant peptides


The present invention relates to the field of biotechnology and genetic engineering, and particularly to the expression of recombinant peptides. The inoculation thereof in cattle results in the production of an immune response capable of adversely affecting rhipicephalus microplus ticks, which feed on the inoculated cattle, decreasing the number and reproductive capacity of this tick species.
Patsos Endustria E Comercio De Produtos BiotecnolÓgicos Ltda


08/18/16
20160237108 

Polynucleotide molecules and uses thereof


The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.. .
Moderna Therapeutics, Inc.


08/18/16
20160235856 

Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types


The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a neurotransmitter transporter. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes..
Nlife Therapeutics, S.l.


08/18/16
20160235843 

Methods for increasing neuronal survival


Described are methods of treating a subject after acute trauma to the head, viral encephalitis, or other causes of acute neurodegeneration, and/or after acute vascular insults, including ischemic and hemorrhagic strokes, the method comprising administering inhibitors of bace1; an inhibitory oligonucleotide targeting bace1; and/or an inhibitory oligonucleotide targeting aplp2. Also described are methods for treating a subject who is at high risk for head trauma, including administering a prophylactically effective amount (i.e., an amount sufficient to reduce the risk of developing or reduce the severity or duration of symptoms of head trauma) of one or more of an inhibitor of bace1; an inhibitory oligonucleotide targeting bace1; or an inhibitory oligonucleotide targeting aplp2..
The General Hospital Corporation


08/11/16
20160230233 

Methods and kits for determining predisposition to develop kidney diseases


Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one apol1 polypeptide variant which is characterized by a higher trypanolytic activity on trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type apol1 polypeptide as set forth in seq id no:1 on the trypanosoma brucei rhodesiense under identical assay conditions; or at least one apol1 nucleotide mutation in the aplo1 genomic sequence set forth in seq id no:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (ld) with the s342g mutation in the apol1 polypeptide set forth in seq id no:1, wherein presence of the apol1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.. .
Ramot At Tel-aviv University Ltd.


08/11/16
20160230224 

Methods and apparatus to sequence a nucleic acid


Methods, systems, apparatus and machine readable media are disclosed to sequence nucleic acid. An example method includes subjecting a sequence of target nucleotide bases captured on a microtransponder to a plurality of sequencing reactions to build a sequence of labeled nucleotide bases that are complementary to and bound to the sequence of target nucleotide bases.
Abbott Molecular Inc.


08/11/16
20160230223 

Method of amplifying nucleic acid sequences


The invention is directed to methods of removing amplicons of non target and/or target nucleic acid sequences having one or more modified (e.g., methylated) nucleotides from a sample wherein the sample comprises the non target nucleic acid and a target nucleic acid sequence to be amplified.. .
Courtagen Life Sciences, Inc.


08/11/16
20160230222 

Methods and compositions for reducing non-specific amplification products


Methods, compositions, systems and kits to amplify or improve amplification of target-specific amplification products by reducing non-specific amplification products (e.g., primer-dimers) when amplifying multiple different nucleotide regions. The methods, compositions, systems and kits described herein may include, or include the use of, one or more resolvases that recognize and bind to and/or cut an aberrant dna structure..

08/11/16
20160230221 

Set of oligonucleotide probes as well as methods and uses thereto


The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes.
Roche Molecular Systems, Inc.


08/11/16
20160230219 

Method for nucleic acid analysis from a region of interest in a biological sample


The invention discloses a method for determining a nucleotide sequence of a nucleic acid segment present in a biological sample, comprising the steps of: a) generating a fluorescent image of the sample by a protocol comprising immunofluorescence detection of at least five different target proteins in the sample; b) selecting a region of interest of the sample by comparing the image to a predetermined criterion; c) removing a subsample from the region of interest, and; d) determining a nucleotide sequence of a nucleic acid segment present in the subsample.. .
Ge Healthcare Bio-sciences Corp.


08/11/16
20160230214 

Centrifuge and loading a device


An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array.
Life Technologies Corporation


08/11/16
20160230201 

Large scale enzymatic synthesis of oligosaccharides


A novel udp-gal regeneration process and its combined use with a galactosyltransferase to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process..
Academia Sinica


08/11/16
20160230189 

Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations


An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating , where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.
Rensselaer Polytechnic Institute


08/11/16
20160230186 

Compositions and methods for controlling diabrotica


The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertevrate pest, for instance through rna interference..
Monsanto Technology Llc


08/11/16
20160230185 

Compositions and methods for controlling diabrotica


The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertebrate pest, for instance through rna interference..
Monsanto Technology Llc


08/11/16
20160230184 

Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use


Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Nidera S.a.


08/11/16
20160230170 

Sirna sequence-independent modification formats for reducing off-target phenotypic effects in rnai, and stabilized forms thereof


Modification formats having modified nucleotides are provided for sirna. Short interfering rna having modification formats and modified nucleotides provided herein reduce off-target effects in rna interference of endogenous genes.
Applied Biosystems, Llc.


08/11/16
20160230166 

Polynucleotide encoding acyl-coa synthetase homolog and use thereof


The present invention relates to an acyl-coa synthetase homolog protein from microorganisms of the genus mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-coa synthetase homolog protein gene from, e.g., mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc..
Suntory Holdings Limited


08/11/16
20160230165 

Polynucleotide encoding acyl-coa synthetase homolog and use thereof


The present invention relates to an acyl-coa synthetase homolog protein from microorganisms of the genus mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-coa synthetase homolog protein gene from, e.g., mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc..
Suntory Holdings Limited


08/11/16
20160230163 

Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities


Isolated aspartyl-trna synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.. .
Atyr Pharma, Inc.


08/11/16
20160230162 

Xylose isomerase genes and their use in fermentation of pentose sugars


The present invention relates to eukaryotic cells which have the ability to isomerise xylose directly into xylulose. The cells have acquired this ability by transformation with nucleotide sequences coding for a xylose isomerase that has one or more specific sequence elements typical for isomerases having the ability of functional expression in yeasts, such as e.g.
Dsm Ip Assets B.v.


08/11/16
20160230160 

Modified beta-lactamases and methods and uses related thereto


Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.. .

08/11/16
20160230158 

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes, Inc.


08/11/16
20160230157 

Glucoamylase variants and polynucleotides encoding same


The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


08/11/16
20160230156 

Recombinant fusion protein possessing nuclease and phosphatase activity


Disclosed herein is a fusion protein possessing both nuclease and phosphatase activities. The described fusion protein simplifies the processing of amplified dna to degrade residual primers and nucleotide triphosphates and thereby facilitates subsequent dna analysis..
Life Technologies Corporation


08/11/16
20160230151 

Microorganism with enhanced l-lysine productivity and producing l-lysine by using same


Provided are a beta prime subunit mutant of rna polymerase, a microorganism of the corynebacterium genus including a polynucleotide coding the same, and a method for producing l-lysine by culturing the same.. .
Cj Cheiljedang Corp.


08/11/16
20160229906 

Mice that produce antigen-binding proteins with ph-dependent binding characteristics


Genetically modified non-human animals are provided that comprise an immunoglobulin heavy chain locus comprising an unrearranged human heavy chain variable region nucleotide sequence comprising an addition of at least one histidine codon or a substitution of at least one endogenous non-histidine codon with a histidine codon. Compositions and methods for making the genetically modified non-human animals as described herein are provided.
Regeneron Pharmaceuticals, Inc.


08/11/16
20160229903 

Thrombin cleavable linker


The present invention provides a chimeric molecule comprising a vwf protein fused to a heterologous moiety via a vwf linker. The invention provides an efficient vwf linker that can be cleaved in the presence of thrombin.
Biogen Ma Inc.


08/11/16
20160229899 

Lucigen yellow (lucy), a yellow fluorescent protein


Described herein are isolated polynucleotides that encode a fluorescent protein which is at least 80% sequence identical to a protein selected from the group consisting of seq. Id.
Lucigen Corporation


08/11/16
20160229882 

Non-enzymatic, salt-mediated synthesis of polynucleic acids


Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid polymerase and lipids, but containing mononucleotides and a monovalent salt; (b) drying and resolubilizing the mixture of step (a) a plurality of times; and (c) recovering polynucleic acids from a resolubilized mixture of step (b). In certain aspects, the method further uses a low ph, e.g.
University Pierre And Marie Curie


08/11/16
20160228567 

Hypoxia-targeted delivery system for pharmaceutical agents


Molecular compositions, nanoparticle compositions, and pharmaceutical compositions of the invention provide for the delivery of a polynucleotide to a hypoxic cell or tissue. The compositions can also be used for the delivery a hydrophobic pharmaceutical agent, either alone or in combination with a polynucleotide, to a hypoxic cell or tissue.
Northeastern University


08/11/16
20160228544 

Single walled carbon nanotube polynucleotide complexes and methods related thereto


The present invention provides single-walled carbon nanotube formulations for the delivery of bioactive agents including large polynucleotides encoding therapeutic proteins into hard-to-transfect cells and methods of making such single-walled carbon nanotube formulations.. .
Ensysce Biosciences, Inc.


08/04/16
20160222453 

Test evaluating the risk of anti-thyroid drug-induced agranulocytosis, and evaluation kit


The present invention provides a test method and an evaluation kit for determining the risk of antithyroid drug-induced agranulocytosis. More particularly, it provides a test method for determining the risk of antithyroid drug-induced agranulocytosis, including testing susceptibility polymorphism to antithyroid drug-induced agranulocytosis, and determining the risk of antithyroid drug-induced agranulocytosis, and an evaluation kit for the risk of antithyroid drug-induced agranulocytosis, containing a polynucleotide capable of detecting susceptibility polymorphism to antithyroid drug-induced agranulocytosis..
Toyo Kohan Co., Ltd.


08/04/16
20160222451 

Method to predict heritable canine non-contact cruciate ligament rupture


Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (cclr) in a dog are described. The method includes isolating genomic dna from a dog and then analyzing the genomic dna from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the cclr phenotype via a genome-wide association study..
Wisconsin Alumni Research Foundation


08/04/16
20160222449 

Major histocompatability coplex single nucleotide polymorphisms


The present disclosure relates to the identification of single nucleotide polymorphisms (snps) in the gamma genomic block in the central region of the major histocompatibility complex (mhc) that can be used for matching transplant donors and recipients and determining disease susceptibility.. .
Conexio Genomics Pty Ltd


08/04/16
20160222446 

Methods and compositions for sequencing nucleic acids using charge


The invention provides methods and compositions, and systems for determining the identity of nucleic acids in nucleotide sequences, including sequences with one or more homopolymer regions. The methods of the invention include improvements so as to accurately identify sequences, including the difficult homopolymer sequences that are encountered during nucleotide sequencing, such as pyrosequencing..
Intelligent Bio-systems, Inc.


08/04/16
20160222445 

Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications


Techniques, methods, devices, and compositions are disclosed that are useful in identifying and sequencing natural and synthetic, and modified and unmodified dna, rna, pna, dna/rna nucleotides. The disclosed techniques, methods, devices, and compositions are useful in identifying various modifications, dna/rna damage, and nucleotide structure, using nanoelectronic quantum tunneling spectroscopy, which may be referred to as qm-seq.
The Regents Of The University Of Colorado, A Body Corporate


08/04/16
20160222442 

Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids


The invention provides miniaturized lateral flow chromatographic and lateral flow chromatographic microarray devices (lfm). The miniaturization of lateral flow nucleic acid detection achieved by the present invention offers reduced reagent use, femtomole sensitivity, excellent linear dynamic range, and rapid detection.
Los Alamos National Security, Llc.


08/04/16
20160222426 

Methods for amplifying nucleic acid using tag-mediated displacement


Disclosed are methods for amplifying a nucleic acid target region using an amplification oligomer comprising a target-binding segment and a heterologous displacer tag situated 5′ to the target-binding segment. Initiation of an amplification reaction from the tagged amplification oligomer produces an amplicon comprising the displacer tag, such that once the complement of the displacer tag has been incorporated into a second amplicon, a displacer oligonucleotide having a sequence substantially corresponding to the displacer tag sequence is used to participate in subsequent rounds of amplification for displacement of an extension product primed from a site within the second amplicon 5′ to the displacer priming site.
Gen-probe Incorporated


08/04/16
20160222422 

Xiamenmycin biosynthesis gene cluster, application and bacterial strain


The present invention involves the application of a gene cluster, and bacterial strains that used in the biosynthesis of xiamenmycin. The nucleotide sequence of the gene cluster is showed as seq id no.1, with the whole length of 5189 base pairs.
Shanghai Jiao Tong University


08/04/16
20160222415 

Nuclear targeting sequences


Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed..
Yeda Research And Development Co. Ltd.


08/04/16
20160222414 

Constructs and methods for delivering molecules via viral vectors with blunted innate immune responses


A cpg-modified recombinant adeno-associated viral (aav) vector is described. The vector carries a nucleic acid molecule comprising aav inverted terminal repeat (itr) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce cpg di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified aav vector.
The Trustees Of The University Of Pennsylvania


08/04/16
20160222409 

Method of targeting gene delivery using viral vectors


Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus.
California Institute Of Technology


08/04/16
20160222403 

Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use


Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Nidera S.a.


08/04/16
20160222393 

Live bacterial vectors for prophylaxis or treatment


A live bacterium, having a dna construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide, comprising a bacterial secretion peptide portion and a non-bacterial immunogenic polypeptide portion, having a nucleotide sequence coding for the non-bacterial immunogenic polypeptide portion which has at least one codon optimized for bacterial expression. The bacterium has a secretion mechanism which interacts with at least the bacterial secretion peptide portion to cause a secretion of the fusion peptide from the bacterium, and a genetic virulence attenuating mutation.
Aviex Technologies Llc


08/04/16
20160222392 

Methods to improve vector expression and genetic stability


The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.. .
International Aids Vaccine Initiative


08/04/16
20160222391 

Compositions and methods for treating amyotrophic lateral sclerosis


Methods for modulating expression of smn1 and/or smn2 in cells obtained from subjects having als or in subjects having als using single stranded oligonucleotides are provided. Methods for treating als using single stranded oligonucleotides are also provided..
Rana Therapeutics, Inc.


08/04/16
20160222386 

Nucleic acid molecule for inhibiting activity of rnai molecule


The purpose of the present invention is to develop and provide a nucleic acid molecule that can specifically and efficiently inhibit the activity of a target rnai molecule and can be produced safely at a low cost. Provided is a nucleic acid molecule for inhibiting the activity of a target rnai molecule.
Osaka City University


08/04/16
20160222384 

Compositions for targeted delivery of sirna


The present invention is directed compositions for targeted delivery of rna interference (rnai) polynucleotides to hepatocytes in vivo. Targeted rnai polynucleotides are administered together with co-targeted delivery polymers.
Arrowhead Madison Inc.


08/04/16
20160222383 

Antisense compositions and methods of making and using same


The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against smad7. The pharmaceutical formulations can be used to treat crohn's disease, ulcera-five colitis and chronic inflammatory bowel disease..
Nogra Pharma Limited


08/04/16
20160222382 

Gene expression and pain


The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate nociceptive signaling in a cell or prevent and/or treat pain in a patient.. .
Adynxx, Inc.


08/04/16
20160222381 

Single-stranded rnai agents containing an internal, non-nucleic acid spacer


Single-stranded rna molecules comprise one or more internal, non-nucleotide spacers, covalently linked with nucleotide portions of the molecule are provided. The single-stranded rna molecules function as guide or antisense strands that are capable of inhibiting gene expression via an rna interference mechanism, and thus represent single-stranded rnai agents.
Sirna Therapeutics, Inc.


08/04/16
20160222380 

Method of preparing nucleic acid molecules


Disclosed is a method of preparing nucleic acid molecules, including: providing a pool of oligonucleotides, each containing restriction enzyme digestion sequences and generic flanking sequences; cleaving the restriction enzyme digestion sequence portions to provide a pool of mixtures comprising the oligonucleotides, each containing the generic flanking sequences at one end, and the oligonucleotides, each containing none of the generic flanking sequences at one end, and; assembling the oligonucleotides using the generic flanking sequences to randomly synthesize nucleic acid fragments.. .
Celemics, Inc.


08/04/16
20160222360 

Novel hydroxyphenylpyruvate dioxygenase polypeptides and methods of use


Novel hydroxyphenyl pyruvate dioxygenase (hppd) polypeptides, variants and fragments thereof, as as well as polynucleotides encoding the same, capable of conferring commercial levels of conferring hppd herbicide resistance or tolerance to plants. Compositions include amino acid sequences, and variants and fragments thereof, for hppd polypeptides, as well as polynucleotides encoding the same.
Syngenta Participations Ag


08/04/16
20160222098 

Nucleotide and amino acid sequences relating to respiratory diseases and obesity


This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby.
Oscient Pharmaceuticals Corporation


08/04/16
20160222094 

Inducible eukaryotic expression system


Compositions and methods for the inducible expression of genes in eukaryotic cells are provided. Expression of a nucleotide sequence of interest encoding a protein of interest is controlled by a regulatory fusion protein that consists of a transcription blocking domain and a ligand-binding domain.
Regeneron Pharmaceuticals, Inc.


08/04/16
20160222087 

Albumin variants


The present invention relates to variants of a parent albumin; the variants comprise one or more mutations in domain ii of albumin which lead to a change in binding affinity to fcrn and/or a change in half-life compared to the “parent” albumin. The invention allows tailoring of binding affinity and/or half-life of an albumin to the requirements and desires of a user or application.
Novozymes Biopharma Dk A/s


08/04/16
20160222051 

Self-assembling oligonucleotides and methods


A composition comprising a double-stranded dna filament having a plurality of single-species of oligonucleotide and chain terminator units, and a method for forming such filaments are disclosed. The oligonucleotide include a first segment, a second segment, pre-determined lengths, and pre-adjusted ratios of a:t/g:c between 1% and 50%.
Creatrone, Inc.






Follow us on Twitter
twitter icon@FreshPatents

###

This listing is a sample listing of patent applications related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.


0.8252

6505

2 - 1 - 134