Nucleotide

Nucleotide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Sparse identity spaces in droplet sequencing
May 25, 2017 - N°20170147746

A method for determining a sequence of a target nucleic acid is described. The method uses a plurality of control oligonucleotides with known sequence and unique identifications to map hybridization signals associated with a plurality of sequencing probes to a loosely packed multi-dimensional dye space, such that a region in the dye space can be associated with one or more ...
NEW Quality score compression for improving downstream genotyping accuracy
May 25, 2017 - N°20170147597

This disclosure provides for a highly-efficient and scalable compression tool that compresses quality scores, preferably by capitalizing on sequence redundancy. In one embodiment, compression is achieved by smoothing a large fraction of quality score values based on k-mer neighborhood of their corresponding positions in read sequences. The approach exploits the intuition that any divergent base in a k-mer likely corresponds ...
NEW Nucleic acid sequences that can be used as primers and probes in the amplification and ...
May 25, 2017 - N°20170145524

The present invention is related to nucleic acid sequences that can be used in the field of virus diagnostics, more specifically the diagnosis of infections with the aids causing human immuno-deficiency virus (hiv). With the present invention nucleotide sequences are provided that can be used as primers and probes in the amplification and detection of hiv-1 nucleic acid. The oligonucleotide ...
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NEW Composition and kit for diagnosing breast cancer including polynucleotide within vesicle, and method of diagnosing ...
May 25, 2017 - N°20170145519

A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microrna (mirna) selected from the group consisting of hsa-mir-126, hsa-mir-23a, hsa-mir-24, hsa-mir-19b, ...
NEW Breast fibroadenoma susceptibility mutations and use thereof
May 25, 2017 - N°20170145504

The present disclosure provides a method of assaying susceptibility and/or confirming diagnosis of breast fibroadenomas development in a human subject. Preferably, the method comprises the steps of performing a nucleic acid-based assay to analyze an isolated polynucleotide encoding at least exon 2 of med12 gene from a sample acquired from the human subject; and regarding the human subject with greater ...
NEW Modified nucleotide reagents
May 25, 2017 - N°20170145502

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
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NEW Methods and apparatus for measuring analytes using large scale fet arrays
May 25, 2017 - N°20170145497

Methods and apparatus relating to very large scale fet arrays for analyte measurements. Chemfet (e. G., isfet) arrays may be fabricated using conventional cmos processing techniques based on improved fet pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid ...
NEW Labeled nucleotide analogs, reaction mixtures, and methods and systems for sequencing
May 25, 2017 - N°20170145496

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
NEW Protected dye-labeled reagents
May 25, 2017 - N°20170145495

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
NEW Nucleic acid ligation systems and methods
May 25, 2017 - N°20170145493

The present disclosure relates to systems and methods for nucleic acid ligation. In particular, the present disclosure provides oligonucleotide adaptors for use in nucleic acid ligation reactions.
NEW Selective oxidation of 5-methylcytosine by tet-family proteins
May 25, 2017 - N°20170145484

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine ...
NEW Selective detection of haemophilus influenzae
May 25, 2017 - N°20170145480

A process for detecting haemophilus influenzae nucleic acid in a sample includes producing an amplification product by amplifying a haemophilus influenzae nucleotide sequence and measuring the amplification product to detect haemophilus influenzae in the sample. Some embodiments allow direct serotype determination in a single step assay. Also provided are reagents and methods for detecting and distinguishing haemophilus influenzae from other ...
NEW Selective detection of haemophilus influenzae
May 25, 2017 - N°20170145479

A process for detecting haemophilus influenzae nucleic acid in a sample includes producing an amplification product by amplifying a haemophilus influenzae nucleotide sequence and measuring the amplification product to detect haemophilus influenzae in the sample. Some embodiments allow direct serotype determination in a single step assay. Also provided are reagents and methods for detecting and distinguishing haemophilus influenzae from other ...
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NEW Method for producing l-lysine using microorganisms having ability to produce l-lysine
May 25, 2017 - N°20170145453

The present invention relates to a modified polynucleotide encoding aspartate kinase (ec:2. 7. 2. 4; hereinafter, referred to as lysc), transketolase (ec:2. 2. 1. 1; hereinafter, referred to as tkt) or pyruvate carboxylase (ec:6. 4. 1. 1; hereinafter, referred to as pyc), in which the initiation codon is substituted with atg, a vector including the same, a microorganism transformed with the vector, and a method for producing l-lysine using ...
NEW Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav
May 25, 2017 - N°20170145440

The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e. G. Adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation ...
NEW Plants having increased tolerance to heat stress
May 25, 2017 - N°20170145435

The invention relates to methods of producing a desired phenotype in a plant by manipulation of gene expression within the plant. The method relates to means which increase the level of expression of a myb-subgroup14 polynucleotide or a myb68 polypeptide. The method also relates to expression of a nucleic acid sequence encoding a myb-subgroup14 or a myb68 transcriptional factor. The ...
NEW Dgat genes for increased seed storage lipid production and altered fatty acid profiles in oilseed ...
May 25, 2017 - N°20170145434

Polynucleotide sequences encoding diacylglycerol acyltransferase genes and the use of these acyltransferases for increased seed storage lipid production and altered fatty acid profiles in oilseed plants are disclosed. Transgenic soybean seed having increased total fatty acid content of at least 20% and altered fatty acids when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. ...
NEW Modulation of nitrate content in plants
May 25, 2017 - N°20170145431

In one aspect, there is provided a mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a member of the clc family of chloride channels and having at least 60% sequence identity to seq id no:1 or seq id no:2 or seq id no:3 or seq id no:4 or seq ...
NEW Combination of anti-clusterin oligonucleotide with hsp90 inhibitor for the treatment of prostate cancer
May 25, 2017 - N°20170145418

The present invention provides a method for treating a mammalian subject affected by prostate cancer comprising i) an oligonucleotide which reduces clusterin expression and ii) a heat shock protein 90 (hsp90) inhibitor each in an amount that when in combination with the other is effective to treat the mammalian subject. The present invention also provides pharmaceutical compositions comprising an amount of ...
NEW Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
May 25, 2017 - N°20170145417

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, ...
NEW Treatment of frataxin (fxn) related diseases by inhibition of natural antisense transcript to fxn
May 25, 2017 - N°20170145414

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of frataxin (fxn), in particular, by targeting natural antisense polynucleotides of frataxin (fxn). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of fxn.