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Nucleotide patents



      
           
This page is updated frequently with new Nucleotide-related patent applications. Subscribe to the Nucleotide RSS feed to automatically get the update: related Nucleotide RSS feeds. RSS updates for this page: Nucleotide RSS RSS


Date/App# patent app List of recent Nucleotide-related patents
07/24/14
20140208458
 Plant having complex disease resistance patent thumbnailnew patent Plant having complex disease resistance
The present invention relates to plants that have been transformed so as to have both disease resistance and acceptable agronomic traits. More specifically, the present invention relates to transgenic plants that have acquired disease resistance through expression in the plants of a polynucleotide encoding the transcription factor wrky45 in an infection-responsive manner, and methods for generating the transgenic plants..
07/24/14
20140208457
 Nuclease fusion protein and uses thereof patent thumbnailnew patent Nuclease fusion protein and uses thereof
The present invention is concerned with nuclease fusion proteins and various uses thereof. Specifically, it relates to a polynucleotide encoding a polypeptide comprising (i) a first module comprising at least a first dna binding domain derived from a homing endonuclease, (ii) a linker, and (iii) a second module comprising at least a second dna binding domain and a cleavage domain derived from a restriction endonuclease, wherein said polypeptide functionally interacts only with dna comprising a dna recognition site for the first dna binding domain and a dna recognition site for the second dna binding domain, and wherein said cleavage domain cleaves dna within a specific dna cleavage site upon binding of the polypeptide.
07/24/14
20140206855
 Methods and compositions for detecting cancers associated with methylation of hmlh1 promoter dna patent thumbnailnew patent Methods and compositions for detecting cancers associated with methylation of hmlh1 promoter dna
Methods are provided for detection of cancers associated with methylation of hmlh1 promoter dna in a subject. The method comprise assaying for the presence of methylated hmlh1 promoter dna in a bodily fluid from a subject.
07/24/14
20140206854
 Targeting micrornas for the treatment of liver cancer patent thumbnailnew patent Targeting micrornas for the treatment of liver cancer
Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a mirna.
07/24/14
20140206852
 Signal-sensor polynucleotides patent thumbnailnew patent Signal-sensor polynucleotides
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmrna molecules.. .
07/24/14
20140206850
 Glyphosate resistance enhancement patent thumbnailnew patent Glyphosate resistance enhancement
The present invention relates to a new method for improving glyphosate resistance of a plant. The method encompasses providing one or more specific mutations in a specific nucleotide sequence in said plant.
07/24/14
20140206755
 Modified polynucleotides for treating arylsulfatase a protein deficiency patent thumbnailnew patent Modified polynucleotides for treating arylsulfatase a protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/24/14
20140206750
 Modulation of apolipoprotein (a) expression patent thumbnailnew patent Modulation of apolipoprotein (a) expression
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a).
07/24/14
20140206747
 Compositions and methods for inhibiting expression of factor v patent thumbnailnew patent Compositions and methods for inhibiting expression of factor v
The invention relates to a double-stranded ribonucleic acid (dsrna) for inhibiting the expression of factor v, comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of factor v. The invention also relates to a pharmaceutical composition comprising the dsrna together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of factor v using the pharmaceutical composition; and methods for inhibiting the expression of factor v in a cell..
07/24/14
20140206746
 Modulation of growth hormone receptor expression and insulin-like growth factor expression patent thumbnailnew patent Modulation of growth hormone receptor expression and insulin-like growth factor expression
Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-i (igf-i). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor.
07/24/14
20140206734
new patent Serotonin transporter gene and treatment of alcoholism
The gene responsible for encoding sert has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (l) and short (s). The ll-genotype is hypothesized to play a key role in the early onset of alcohol use.
07/24/14
20140206716
new patent Methods and compositions for the assessment of drug response
The present invention provides methods for predicting or determining a subject's response to an antiplatelet agent, and methods for determining a subject's suitability to a treatment regime or intervention for a disease associated with platelet aggregation, using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's response to an antiplatelet agent.
07/24/14
20140206594
new patent Polypeptides having protease activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/24/14
20140206581
new patent Methods of making di-tagged dna libraries from dna or rna using double-tagged oligonucleotides
Disclosed are methods, compositions and kits related to making double-tagged dna libraries from rna/dna samples. A double-tagged oligonucleotide (dto) is employed to efficiently add two different tags to ends of dnas to make a double-tagged dna libraries.
07/24/14
20140206579
new patent Dna libraries encoding frameworks with synthetic cdr regions
A synthetic dna library or a member of a synthetic dna library of antibodies or fragments of antibody molecules having heavy chain(s) and lacking light chain(s) is described wherein the cdr within variable domains are synthesized using randomly assembled trinucleotide phosphoramidites (trimer phosphoramidites) to eliminate unwanted cysteine amino acids and/or stop codons.. .
07/24/14
20140206561
new patent Method for providing information on antidepressant therapeutic effect using single nucleotide polymorphism
Disclosed is a method for providing information on the therapeutic effect of an ssri antidepressant by identifying tph2 gene polymorphism rs4760815, slc6a4 gene polymorphism 5-httlpr, slc6a4 gene polymorphism rs2066713, gad1 gene polymorphism rs3828275, and grik2 gene polymorphism rs543196. Through the disclosed method, it is possible to select an antidepressant based on genetic information, to prevent the worsening or relapse of depression, and to establish customized depression treatment models which are effective in the development of customized new drugs, and appropriate for korean people.
07/24/14
20140206554
new patent Methods and systems for processing polynucleotides
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing..
07/24/14
20140206553
new patent Massive parallel method for decoding dna and rna
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of dna in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —oh group at the 3′-position of the deoxyribose..
07/24/14
20140206551
new patent Method for the identification of the clonal source of a restriction fragment
The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end.
07/24/14
20140206550
new patent Step-wise nucleic acid sequencing with catalytic and non-catalytic metals
The application relates to methods, and systems for nucleotide sequencing comprising producing polymerase reactions that comprise both catalytic and non-catalytic divalent metal ions. Polymerase/template/primer complexes are immobilized on a substrate.
07/24/14
20140206102
new patent Methods and materials for detecting c9orf72 hexanucleotide repeat expansion positive frontotemporal lobar degeneration or c9orf72 hexanucleotide repeat expansion positive amyotrophic lateral sclerosis
This document provides methods and materials for detecting c9orf72 hexanucleotide (ggggcc) (seq id no: 3) repeat expansion positive (c9+) frontotemporal lobar degeneration or c9+ amyotrophic lateral sclerosis. For example, methods and materials related to using anti-(gp)8 (seq id no: 2) antibodies to identify mammals (e.g., humans) having c9+ ftld or c9+ als are provided..
07/24/14
20140206057
new patent Novel yeast strains
There is provided an alkene-producing yeast cell comprising a bacterial fatty acid decarboxylase enzyme, which may comprise the amino acid sequence seq id no:1 or a functional variant or portion thereof. The alkene may have 15, 17 or 19 carbon atoms.
07/24/14
20140206035
new patent Polypeptides having glucoamylase activity and polynucleotides encoding same
Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains..
07/24/14
20140206026
new patent Method for screening alpha-amylases
The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
07/24/14
20140206024
new patent Stable nad/nadh derivatives
The present invention provides for stable nicotinamide adenine dinucleotide (nad/nadh) and nicotinamide adenine dinucleotide phosphate (nadp/nadph) derivatives of formula (i), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.. .
07/24/14
20140206005
new patent Method and kit for dna typing of hla gene
The purpose of the present invention is to provide a method and kit for highly precise dna typing, in which ambiguity derived from phase ambiguity is eliminated. The present invention provides a method for the dna typing of hla, which is characterized by comprising: (1) a step of preparing a set of primers which can respectively anneal specifically to an upstream region and a downstream region of each of hla-a, hla-b, hla-c, hla-dqa1, hla-dqb1, hla-dpa1 and hla-dpb1 gene in the nucleotide sequence for the human genome, and a set of primers which can respectively anneal specifically to exon-2 and a 3′-side non-translated region in hla-drb1; (2) a step of carrying out the pcr amplification of a sample to be tested (dna) using the sets of primers; (3) a step of determining the nucleotide sequence for a pcr-amplified product; and (4) an optional step of carrying out the homology search in a data base..
07/24/14
20140206002
new patent Methods of diagnosing breast cancer
The disclosed subject matter is based on the discovery that a mutation (a single nucleotide polymorphism or “snp”) in the gene encoding abraxas (also referred to as abra1, ccdc98 or fam175a), is associated with susceptibility to cancer, e.g., breast cancer. In particular, the disclosed subject matter is based on the identification of a heterozygous alteration in the abraxas gene that is associated with breast cancer and specifically correlated with familial cancer.
07/24/14
20140206001
new patent Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
Provided are methods of enrichment and detection of target nucleic acids during target amplification in the presence of excess amounts of highly homologous sequences, said methods having substantial diagnostic utility (e.g., cancer diagnostics). Provided are amplification reaction mixtures having at least one cleavage-directing oligonucleotide, the respective binding sites of which, for the target and homologous sequences, include one or more nucleotide positions differing in sequence between the target homologous sequences.
07/24/14
20140205653
new patent Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (cdn) immune stimulators that activates dcs via a recently discovered cytoplasmic receptor known as sting (stimulator of interferon genes). In particular, the cdns of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce sting-dependent tbk1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure rp,rp or rp,sp stereoisomers, and particularly substantially pure rp,rp, or rpsp cdn thiophosphate diastereomers..
07/24/14
20140205652
new patent Novel method and compositions
The present invention relates to, inter alia, a method of raising an immune response against a pathogen which comprises administering (i) one or more first immunogenic polypeptides derived from said pathogen; (ii) one or more adenoviral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from said pathogen; and (iii) an adjuvant; wherein the one or more first immunogenic polypeptides, the one or more adenoviral vectors and the adjuvant are administered concomitantly. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing said polypeptides, adenoviral vectors and adjuvants..
07/24/14
20140205633
new patent Immunostimulatory oligodeoxynucleotides
The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease, to methods for the detection of such oligodeoxynucleotides and to cells to be used in these method.. .
07/24/14
20140205604
new patent Antigen binding constructs
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain fc region of an antibody, wherein each epitope binding domain in capable of binding to vegf, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with vegf signalling, such as diabetic macular edema (dme), wet age-related macular degeneration (wet amd). Diabetic retinopathy, retinal vein occlusion (rvo), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs..
07/17/14
20140201871
Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
07/17/14
20140201865
Methods for expanding color palette in dendrobium orchids
A nucleotide sequence encoding flavonoid 3′-hydroxylase (f3′h) of dendrobium, a method of producing a transgenic flower color-changed dendrobium plant, and a transgenic flower color-changed dendrobium plant are provided by this invention.. .
07/17/14
20140201864
Polynucleotides and polypeptides in plants
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
07/17/14
20140201861
Polynucleotides and polypeptides that confer increased yield, size or biomass
The present description relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant, including the traits of increased yield, size or biomass.. .
07/17/14
20140200338
Oligonucleotides containing high concentrations of guanine monomers
This invention pertains to methods for oligonucleotide synthesis, specifically the synthesis of oligonucleotides that contain a high content of guanine monomers. In more detail, the invention relates to a method for coupling a nucleoside phosphoramidite during the synthesis of an oligonucleotide to a universal support, to a first nucleoside, or to an extending oligonucleotide.
07/17/14
20140200264
Modified polynucleotides for treating carboxypeptidase n, polypeptide 1 protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140200263
Modified polynucleotides for treating galactosidase, alpha protein deficiency
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140200262
Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140200261
Signal-sensor polynucleotides for the alteration of cellular phenotypes
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmrna molecules.. .
07/17/14
20140200161
Method of preparing an adduct
A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is hybridized at least one pna-encoded molecule.. .


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This listing is a sample listing of patent applications related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.
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