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Nucleotide patents



      
           
This page is updated frequently with new Nucleotide-related patent applications. Subscribe to the Nucleotide RSS feed to automatically get the update: related Nucleotide RSS feeds. RSS updates for this page: Nucleotide RSS RSS


Date/App# patent app List of recent Nucleotide-related patents
10/23/14
20140317786
 Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same patent thumbnailPolypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
10/23/14
20140317783
 Polynucleotides, polypeptides and methods for enhancing photossimilation in plants patent thumbnailPolynucleotides, polypeptides and methods for enhancing photossimilation in plants
The present invention relates generally to the field of molecular biology and regards various polynucleotides, polypeptides and methods that may be employed to enhance yield in transgenic plants. Specifically the transgenic plants may exhibit increased yield, increased biomass or increased photoassimilation..
10/23/14
20140317781
 Isolated polynucleotides and polypeptides, transgenic plants comprising same and uses thereof in improving abiotic stress tolerance, nitrogen use efficiency, biomass, vigor or yield of plants patent thumbnailIsolated polynucleotides and polypeptides, transgenic plants comprising same and uses thereof in improving abiotic stress tolerance, nitrogen use efficiency, biomass, vigor or yield of plants
Methods of improving abiotic stress tolerance, nitrogen use efficiency, biomass, vigor or yield of a plant are provided. According to an aspect the method comprising expressing within the plant an exogenous polynucleotide having a nucleic acid sequence at least 90% identical to seq id nos: 103, 101-102, 104-216, 223-227, 264-416, wherein the nucleic acid sequence is capable of regulating abiotic stress tolerance of the plant, thereby improving abiotic stress tolerance, nitrogen use efficiency, biomass, vigor or yield of the plant.
10/23/14
20140317779
 P0 gene silencing constructs and use patent thumbnailP0 gene silencing constructs and use
A recombinant bmyv p0 viral nucleotide sequence when transcribed in a cell is capable of forming a double stranded self-complementary rna sequence.. .
10/23/14
20140317773
 Yield traits for maize patent thumbnailYield traits for maize
Methods for introgressing an allele of interest of a locus associated with a yield trait into zea mays germplasm are provided. In some embodiments, the methods include providing a zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by pcr amplification of a zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into zea mays germplasm that lacks the allele.
10/23/14
20140316716
 Methods, systems, and computer readable media for improving base calling accuracy patent thumbnailMethods, systems, and computer readable media for improving base calling accuracy
A method includes exposing template polynucleotide strands, sequencing primers, and polymerase to flows of nucleotide species; obtaining a series of measured intensity values and randomly selecting a training subset therefrom; generating series of base calls using a base caller and aligning the series of base calls to a reference genome or sequence using an aligner; determining intensity value thresholds and parameters of a linear transformation corresponding to different homopolymer lengths and nucleotide species; generating series of base calls corresponding to the series of measured intensity values using at least some of the parameters of a linear transformation; and recalibrating the series of base calls corresponding to the plurality of series of measured intensity values using at least some of the intensity value thresholds.. .
10/23/14
20140316126
 Rna molecules and uses thereof patent thumbnailRna molecules and uses thereof
The invention relates to a method of designing a short rna molecule to increase the expression of a target gene in a cell through the down-regulation of a non-coding rna transcript, said method comprising the steps of: a) obtaining the nucleotide sequence of the coding strand of the target gene, at least between 200 nucleotides upstream of the gene's transcription start site and 200 nucleotides downstream of the gene's transcription start site; b) determining the reverse complementary rna sequence to the nucleotide sequence determined in step a); and c) designing a short rna molecule which is the reverse complement or has at least 80% sequence identity with the reverse complement of a region of the sequence determined in step b); wherein said method does not include a step in which the existence of said non-coding rna transcript is determined; and to such short rna molecules and uses thereof.. .
10/23/14
20140316123
 Ena nucleic acid pharmaceuticals capable of modifying splicing of mrna precursors patent thumbnailEna nucleic acid pharmaceuticals capable of modifying splicing of mrna precursors
Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cdna (gene bank accession no. Nm_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides..
10/23/14
20140315987
 Cholecystokinin b receptor (cckbr) mini-promoters patent thumbnailCholecystokinin b receptor (cckbr) mini-promoters
Isolated polynucleotides comprising a cckbr mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
10/23/14
20140315984
 Methods and compositions for treatment of diabetes and related disorders patent thumbnailMethods and compositions for treatment of diabetes and related disorders
The present invention provides a method of stimulating growth of a pancreatic islet beta cell and/or enhancing glucose stimulated insulin secretion of a pancreatic islet beta cell, comprising delivering to the cell an exogenous nucleotide sequence encoding nkx6.1 transcription factor.. .
10/23/14
20140315982
Double-stranded nucleic acid molecule for gene expression control
Provided are an improved double-stranded nucleic acid molecule involved in gene expression control mediated by a gene silencing mechanism, a method of producing the molecule, and a pharmaceutical composition comprising the double-stranded nucleic acid molecule. The double-stranded nucleic acid molecule for gene expression control comprises an antisense strand having a length of 18 to 28 nucleotides and a sense strand including a complementary moiety composed of a sequence sufficiently complementary to the antisense strand and a protruding single-stranded 5′-end moiety having a length of 2 to 100 nucleotides.
10/23/14
20140315978
Compositions and methods for treatment of prostate and other cancers
Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp27. A therapeutic agent, for example an antisense oligonucleotide or rnai nucleotide inhibitor with sequence specificity for hsp27 mrna, for example human hsp27 mrna, is administered to an individual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount.
10/23/14
20140315851
Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
Provided herein are compounds, compositions, and methods of using them to treat infections, neoplastic disease, inflammatory disease, and pain. Such compounds are nucleotides, acyclonucleotides, and anp phosphonates conjugated with forms and/or moieties of vitamin b6 for delivery past the cell membrane and into the cell..
10/23/14
20140315822
High mast2-affinity polypeptides and uses thereof
The invention relates to polypeptides containing a cytoplasmic domain ending with a mast-2 binding domain, from 11 to 13 residues, the first two residues of which are s and w, and the last four residues of which are q, t, r and l, said polypeptides presenting a high affinity for the pdz domain of the human mast2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same.
10/23/14
20140315795
Compositions and methods for selective delivery of oligonucleotide molecules to cell types
The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a receptor which can be internalised by the cell in response to the binding of said selectivity agent. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interest and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of contrast agents to the cells for diagnostic purposes..
10/23/14
20140315762
Methods for tagging dna-encoded libraries
The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-o-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation..
10/23/14
20140315758
Cancer antigen-specific t-cell receptor gene, peptide encoded by the gene, and use of them
Disclosed are: a nucleotide sequence and an amino acid sequence for cdr3 region of t-cell receptor (tcr) gene of wt1-specific cytotoxic t-cell (ctl) for wt1 protein; a method for the detection or treatment of cancer using the nucleotide sequence or the amino acid sequence; and a chip, a primer set, a kit, an apparatus and the like for use in the detection of cancer, each of which comprises the nucleotide sequence or the amino acid sequence.. .
10/23/14
20140315757
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (pcr) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence.
10/23/14
20140315755
Genome-wide antisense oligonucleotide and rnai
The present invention relates to the generation and construction of libraries for genome-wide antisense oligonucleotide and sirna.. .
10/23/14
20140315750
Selective detection of norovirus
A process for detecting norovirus nucleic acid in a sample is provided including producing an amplification product by amplifying a norovirus nucleotide sequence using a forward primer of seq id no: 1, 4, or 10 and a reverse primer of seq id no: 2, 5, or 11, and detecting the amplification product to detect norovirus in the sample. Also provided are reagents and methods for detecting and distinguishing gi or gil norovirus from other infectious agents.
10/23/14
20140315747
Bifunctional oligonucleotide probe for universal real time multianalyte detection
The invention relates to a mediator probe comprising a probe region and a mediator region. Furthermore, the invention relates to a system comprising a mediator probe and a detection molecule, use of that system and a method for detection of at least one target molecule..
10/23/14
20140315745
Broad detection of dengue virus serotypes
Processes for detecting dengue virus (denv) nucleic acid in a sample are provided including producing an amplification product by amplifying denv nucleotide sequence and detection of an amplification by hybridization of a probe or other technique. The processes use primers or probes with introduced mutations and or degenerate bases that provide excellent superiority in detection and serotyping of denv in a sample..
10/23/14
20140315735
Cancer antigen-specific t-cell receptor gene, peptide encoded by the gene, and use of them
Disclosed are: a nucleotide sequence and an amino acid sequence for cdr3 region of t-cell receptor (tcr) gene of wt1-specific cytotoxic t-cell (ctl) for wt1 protein; a method for the detection or treatment of cancer using the nucleotide sequence or the amino acid sequence; and a chip, a primer set, a kit, an apparatus and the like for use in the detection of cancer, each of which comprises the nucleotide sequence or the amino acid sequence.. .
10/23/14
20140315730
Scalable characterization of nucleic acids by parallel sequencing
A method for detecting the presence or absence of a target polynucleotide in a sample is described.. .
10/23/14
20140315729
Detection of nucleic acid reactions on bead arrays
The present invention is directed to methods and compositions for the use of micro sphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e.
10/23/14
20140315314
Engineered listeria and methods of use thereof
The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes..
10/23/14
20140315274
Methods for production of archeae protease in yeast
The invention relates to: a method for producing a protease in yeast, comprising providing a yeast host cell comprising at least one polynucleotide expression construct encoding a first polypeptide secreted by the host cell in translational fusion with a second polypeptide, wherein the second polypeptide is a protease having a mature amino acid sequence similar to that of seq id no:2; the corresponding yeast host cell and the expression construct.. .
10/23/14
20140315249
Inducible eukaryotic expression system
Compositions and methods for the inducible expression of genes in eukaryotic cells are provided. Expression of a nucleotide sequence of interest encoding a protein of interest is controlled by a regulatory fusion protein that consists of a transcription blocking domain and a ligand-binding domain.
10/23/14
20140315211
Methods for suppression pcr
Provided herein are approaches for the detection, identification, and/or selective amplification of specific target species or target variants of nucleic acid sequences, even within an excess of unwanted similar sequences or variants. These approaches include methods, assays, and kits for suppression pcr that require, in part, dna polymerase that lacks 5′-3′ exonuclease activity, and a pcr primer, termed a forward selective primer or a nunchaku primer.
10/23/14
20140315207
Molecular beacon based assay for the detection of biomarkers for breast cancer metastasis
The invention encompasses molecular beacon (mb) probes for monitoring the presence of human breast cancer biomarkers and for the analysis of breast cancer metastasis. The molecular beacon is an oligonucleotide probe which sensitively and specifically identifies biomarker mrna in samples, in the presence of serum, in minimal time using fluorescence detection.
10/23/14
20140315201
Method for high-throughput screening of transgenic plants
The invention relates to a method for quantifying levels of expression and/or quantifying copy number of a heterologous polynucleotide in a transgenic plant using quantitative or real-time polymerase chain reaction (qpcr or real-time pcr), wherein the real-time pcr is performed using a primer set specific to a heterologous terminator sequence operably linked to the heterologous polynucleotide.. .
10/23/14
20140315197
Multifunctional probe-primers
Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple aliquots, and (3) a decoding and detection step in which the presence, absence, quantity, or relative amount of the target sequence in the aliquots is determined.
10/23/14
20140315196
Dna diagnostic screening for turner syndrome and sex chromosome disorders
The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the x and y chromosomes.. .
10/23/14
20140315191
Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
This invention provides a process for sequencing single-stranded dna employing modified nucleotides.. .
10/23/14
20140314858
Ipnv-isav bivalent vaccine using a virus-like particle-based platform and methods of using the same
The present invention provides bivalent oral vaccines against infectious pancreatic necrosis virus (ipnv) and infectious salmon anemia virus (isav). Yeast cells comprise an expression vector comprising (i) a polynucleotide sequence encoding a vp2 capsid protein of ipnv and (ii) a polynucleotide sequence encoding one or more antigenic epitopes of hemaglutinin of isav.
10/23/14
20140314854
Methods and compositions for rnai-based cancer treatment
The present invention generally concerns methods and nucleotide-based compositions for treating metastatic cancer that is associated with a primary tumor or a few tumors at the primary organ.. .
10/23/14
20140314843
Engineered phenylalanine ammonia lyase polypeptides
The present invention provides engineered phenylalanine ammonia-lyase (pal) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (pal) polypeptides.. .
10/23/14
20140314816
Stabilized stat3 decoy oligonucleotides and uses therefore
The present invention is based, at least in part, on novel, unimolecular stat3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting stat3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer..
10/23/14
20140314802
Novel compositions and methods
The present invention is directed to a polypeptide which comprises: (i) an rv2386c protein sequence; (ii) a variant of an rv2386c protein sequence; of (iii) an immunogenic fragment of an rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis..
10/23/14
20140314759
Isolated nucleotide sequences encoding gdf traps
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.. .
10/23/14
20140314713
Methods for determining treatment response in patients infected with hcv genotype 4
The present invention relates to a method for testing whether a patient infected with hcv genotype 4 could achieve a sustained virological response (svr) to the combination of interferon-alpha and ribavirin comprising determining the patient's genotype for the single nucleotide polymorphism rs 12979860 wherein the presence of the better response allele c indicates a high chance to achieve a sustained virological response (svr) and the presence of the allele t indicates a lower chance to achieve a sustained virological response (svr).. .


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This listing is a sample listing of patent applications related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.
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