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Nucleotide patents



      

This page is updated frequently with new Nucleotide-related patent applications.




Date/App# patent app List of recent Nucleotide-related patents
07/21/16
20160210404 
 Methods of quality control using single-nucleotide polymorphisms in pre-implantation genetic screening patent thumbnailMethods of quality control using single-nucleotide polymorphisms in pre-implantation genetic screening
The present invention provides methods for validating results of a pre-implantation genetic screen. Methods of the invention increase the efficacy of the common pgs assay fast-seqs by taking advantage of single-nucleotide polymorphisms (snps) generated from the assay to confirm copy number calls, detect errors, identify samples, and recognize and identify sources of contamination.
Good Start Genetics, Inc.


07/21/16
20160209417 
 Methods of diagnosing, classifying and treating endometrial cancer and precancer patent thumbnailMethods of diagnosing, classifying and treating endometrial cancer and precancer
Diagnostic and therapeutic applications for endometrial cancer are described. The diagnostic and therapeutic applications are based on certain activation mutations in the fgfr2 gene and its expression products.
Washington University


07/21/16
20160209350 
 Compositions, devices, systems, and methods for using a nanopore patent thumbnailCompositions, devices, systems, and methods for using a nanopore
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore.
The Regents Of The University Of California


07/21/16
20160208346 
 Method and composition for detection of oncogenic hpv patent thumbnailMethod and composition for detection of oncogenic hpv
Probes for the detection of oral oncogenic human papillomavirus (hpv) are described. The probe includes a polynucleotide having at least 90% sequence identity to a polynucleotide complementary to a microrna that has altered expression in response to oncogenic hpv infection.
Notre Dame Du Lac


07/21/16
20160208344 
 High throughput nucleic acid sequencing by expansion patent thumbnailHigh throughput nucleic acid sequencing by expansion
Nucleic acid sequencing methods and related products are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the daughter strand comprising a plurality of subunits coupled in a sequence corresponding to a contiguous nucleotide sequence of all or a portion of the target nucleic acid, wherein the individual subunits comprise a tether, at least one probe or nucleobase residue, and at least one selectively cleavable bond.
Stratos Genomics


07/21/16
20160208335 
 Use of rhoa in cancer diagnosis and inhibitor screening patent thumbnailUse of rhoa in cancer diagnosis and inhibitor screening
Disclosed are a novel method of detecting cancer, a method of screening inhibitors and anticancer agents that target cancer-related molecules, rhoa polypeptide having mutation and a polynucleotide encoding the polypeptide as a therapeutic agent for cancer, and a method of detecting cancer using the polypeptide or polynucleotide. Also disclosed are a vector and a host cell comprising the polynucleotide, a method of screening therapeutic agents for cancer comprising the polypeptide and/or the polynucleotide, and a therapeutic agent for cancer comprising sirna having a silencing effect on rhoa mutant..
Chugai Seiyaku Kabushiki Kaisha


07/21/16
20160208326 
 Method and kit for dna typing of hla gene patent thumbnailMethod and kit for dna typing of hla gene
The purpose of the present invention is to provide a method and kit for highly precise dna typing, in which ambiguity derived from phase ambiguity is eliminated. The present invention provides a method for the dna typing of hla, which is characterized by comprising: (1) a step of preparing a set of primers which can respectively anneal specifically to an upstream region and a downstream region of each of hla-a, hla-b, hla-c, hla-dqa1, hla-dqb1, hla-dpa1 and hla-dpb1 gene in the nucleotide sequence for the human genome, and a set of primers which can respectively anneal specifically to exon-2 and a 3′-side non-translated region in hla-drb1; (2) a step of carrying out the pcr amplification of a sample to be tested (dna) using the sets of primers; (3) a step of determining the nucleotide sequence for a pcr-amplified product; and (4) an optional step of carrying out the homology search in a data base..
Genodive Pharma Inc.


07/21/16
20160208325 
 Compositions and methods for single g-level hla typing patent thumbnailCompositions and methods for single g-level hla typing
Provided are methods, kits, and systems useful in the performance of analysis and reporting of highly polymorphic loci, including, in particular, the performance of analysis and reporting of hla typing. Combining one-step sequencing and sequence-specific oligonucleotide probe hybridization, the methods, kits, and systems offer improved efficiency of hla typing while providing detailed sequencing information.
Georgetown University


07/21/16
20160208324 
 Method of nucleotide detection patent thumbnailMethod of nucleotide detection
The invention relates to an additive which can be added to buffers used in nucleotide detection processes and improved methods of nucleic acid sequencing using this additive. In particular the invention relates to use of the additive to improve the efficiency of fluorescence-based multiple cycle nucleic acid sequencing reactions..
Illumina Cambridge Limited


07/21/16
20160208322 
 Nucleic acid encoding reactions patent thumbnailNucleic acid encoding reactions
Described herein are methods useful for incorporating one or more adaptors and/or nucleotide tag(s) and/or barcode nucleotide sequence(s) one, or typically more, target nucleotide sequences. In particular embodiments, nucleic acid fragments having adaptors, e.g., suitable for use in high-throughput dna sequencing are generated.
Fluidigm Corporation


07/21/16
20160208321 

Suppression of non-specific amplification with high-homology oligonucleotides


The invention comprises suppressor oligonucleotides for reducing amplification of a non-target nucleic acid sequences; the method of designing and using such oligonucleotides, as well as kits and reaction mixtures.. .
Roche Molecular Systems, Inc.


07/21/16
20160208318 

Nucleotide transient binding for sequencing methods


Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (snp) analyses.
Life Technologies Corporation


07/21/16
20160208316 

Method for the in vitro detection of strains of legionella pneumophila resistant to antibiotics


Disclosed is a method for the in vitro detection of strains of legionella pneumophila, resistant to antibiotics, in particular to the fluoroquinolones. Also disclosed are nucleotide probes and a kit of reagents allowing the detection of legionella pneumophila bacterial strains that are resistant to antibiotics, in particular of the fluoroquinolone type..
Centre Hospitalier Universitaire De Grenoble


07/21/16
20160208313 

Synthesis of four-color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods


This invention provides a process for making 3′-o-allyl-dgtp-pc-biodopy-fl-510, 3′-o-allyl-datp-pc-rox, 3′-o-allyl-dctp-pc-bodipy-650 and 3′-o-allyl-dutp-pc-r6g, and related methods.. .
The Trustees Of Columbia University In The City Of New York


07/21/16
20160208301 

Polypeptides having xylanase activity and polynucleotides encoding same


The present invention relates to polypeptides having xylanase activity and catalytic domains and polynucleotides encoding the polypeptides and catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and catalytic domains..
Novozymes A/s


07/21/16
20160208291 

Glycerol and acetic acid converting yeast cells with improved acetic acid conversion


D) one or more nucleotide sequence encoding a dihydroxyacetone kinase (e.c. 2.7.1.28 or e.c.

07/21/16
20160208286 

Alphaviral vectors and cell lines for producing recombinant proteins


The present invention relates to polynucleotides and alphaviral vectors for the expression of genes of interest in mammalian cells. Additionally, the invention relates to cells which comprise said polynucleotides and alphaviral vectors and are capable of stably expressing one or more genes of interest.
3p Biopharmaceuticals, S.l.


07/21/16
20160208280 

Genetic inhibition by double-stranded rna


A process is provided of introducing an rna into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo.
University Of Massachusetts


07/21/16
20160208272 

Plant genome modification using guide rna/cas endonuclease systems and methods of use


Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide rna/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed.
Pioneer Hi-bred International, Inc.


07/21/16
20160208271 

Methods for producing genetic modifications in a plant genome without incorporating a selectable transgene marker, and compositions thereof


Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell, without incorporating a selectable transgene marker. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed, without incorporating a selectable transgene marker.
Pioneer Hi-bred International, Inc.


07/21/16
20160208267 

Antisense oligonucleotides against neutral sphingomyelinase and neutral sphingomyelinase inhibitor gw4869 for degenerative neurological disorders


Alzheimer's disease (ad) is the most common human neurodegenerative disease of the cns resulting in progressive neuronal death and memory loss. Despite intense investigations, no effective therapy is available to stop its onset or halt its progression.
Rush University Medical Center


07/21/16
20160208265 

Rna interference agents for gst-pi gene modulation


This invention provides compounds, compositions and methods for modulating the expression of human gst-π using rna interference. The rna interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.
Nitto Denko Corporation


07/21/16
20160208261 

Methods and compositions for inhibiting the function of polynucleotide sequences


A therapeutic composition for inhibiting the function of a target polynucleotide sequence in a mammalian cell includes an agent that provides to a mammalian cell an at least partially double-stranded rna molecule comprising a polynucleotide sequence of at least about 200 nucleotides in length, said polynucleotide sequence being substantially homologous to a target polynucleotide sequence. This rna molecule desirably does not produce a functional protein.
Alnylam Pharmaceuticals, Inc.


07/21/16
20160208260 

Complex containing oligonucleotide having immunopotentiating activity and use thereof


The present invention provides an oligodeoxynucleotide containing humanized k type cpg oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3′-side of the humanized k type cpg oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan..
Daiichi Sankyo Company, Limited


07/21/16
20160208259 

Targeting micrornas for metabolic disorders


Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of blood glucose level, the reduction of gluceoneogenesis, the improvement of insulin resistance and the reduction of plasma cholesterol level.
Eth Zurich


07/21/16
20160208258 

Mir-92 inhibitors and uses thereof


The present invention provides oligonucleotide inhibitors of mir-92 and methods of using said inhibitors for inhibiting the function and/or activity of mir-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates mir-92 function and/or activity..
Miragen Therapeutics, Inc.


07/21/16
20160208256 

Rna interference agents for p21 gene modulation


This invention provides compounds, compositions and methods for modulating the expression of human p21 using rna interference. The rna interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.
Nitto Denko Corporation


07/21/16
20160208255 

Rna agents for p21 gene modulation


This invention provides compounds, compositions and methods for modulating the expression of human p21 using rna interference. The rna interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.
Nitto Denko Corporation


07/21/16
20160208254 

Rna agents for gst-pi gene modulation


This invention provides compounds, compositions and methods for modulating the expression of human gst-π using rna interference. The rna interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.
Nitto Denko Corporation


07/21/16
20160208249 

Compositions and methods for inducing senescence in cancer cells


The invention relates to nucleic acid sequences as well as to modified oligonucleotides (odns) comprising a p52 binding site derived from the ezh2 promoter region, as well as to compositions and methods for treating cancer. The invention relates to peptides derived from p52 as well as to compositions and methods for treating cancer.
Centre Hopitalier Universitaire De Nice


07/21/16
20160208247 

Methods of use of sphingolipid polyalkylamine oligonucleotide compounds


Provided herein are sphingolipid-polyalkylamine sirna compounds pharmaceutical compositions comprising such compounds, and methods of use in therapy.. .
Qbi Enterprises Ltd.


07/21/16
20160208244 

Modulation of kcnh2 isoform expression by oligonucleotides as a therapeutic approach for long qt syndrome


Oligonucleotides with activity in preventing poly(a) adenylation at intron 9 of the kcnh2 gene, as well as pharmaceutical compositions comprising the oligonucleotides and methods of using the oligonucleotides to treat long qt syndrome in a subject are disclosed. The oligonucleotides include antisense sequences corresponding to sites termed dse-1 and dse-2 in intron 9..
Oregon Health & Science University


07/21/16
20160208239 

Expression vector production and high-throughput cell screening


The present invention relates inter alia to expression vector production as well as application to the production of host cells for protein repertoire expression and high-throughput screening. The invention also relates to primers useful for pcr amplification of nucleotide sequences encoding human antibody variable domains..
Kymab Limited


07/21/16
20160208234 

Protease variants and polynucleotides encoding same


The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s


07/21/16
20160208229 

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Novozymes Inc.


07/21/16
20160208019 

T cell activating bispecific antigen binding molecules


The present invention generally relates to novel bispecific antigen binding molecules for t cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides.
Hoffmann-la Roche Inc.


07/21/16
20160208017 

Mutant interleukin-2 polypeptides


The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the il-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant il-2 polypeptides, polynucleotide molecules encoding the mutant il-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules.
Roche Glycart Ag


07/21/16
20160207996 

Antibodies to complex targets


The present invention relates to antibodies and antigen binding fragments thereof derived from antibodies raised by dna immunization of host animals, particularly camelids (e.g. Llama).
Argen-x N.v.


07/21/16
20160207022 

Dna millichip


The present invention provides novel arrays of oligonucleotide probes immobilized on a solid support in the form of a chip (millichip), which can be used for rapid and inexpensive analysis of nucleic acids. The arrays can have a plurality of different oligonucleotide probes that can provide for whole genome gene expression analysis.
Wisconsin Alumni Research Foundation


07/21/16
20160206750 

Block copolymers


Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell.
Phaserx, Inic.


07/21/16
20160206738 

Thiobase compounds for photodynamic therapy


A method of using a compound in a phototherapy procedure includes administering to a subject in need of treatment a therapeutically effective amount of a thio-substituted nucleobase, nucleoside, nucleotide, and/or analogs thereof; and exposing the administered compound to electromagnetic radiation.. .
Case Western Reserve University


07/21/16
20160206716 

Compositions comprising angiogenic factors and methods of use thereof


The present invention provides recombinant listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a pest-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.. .
The Trustees Of The University Of Pennsylvania


07/21/16
20160205886 

Plants with an intense fruit phenotype


The present invention relates to plants comprising a modified amount, activity or function of agl11-like protein, wherein the plant is a member of plant family cucurbitaceae or of species solanum lycopersicum; characterized in that the plant is not a solanum lycopersicum plant having a deletion from nucleotide 1042 to nucleotide 637 upstream of the atg start codon of seq id no: 1.. .
Nunhems B.v.


07/14/16
20160203261 

Systems and methods for identifying structurally or functionally significant nucleotide sequences


Provided are methods, systems, and computer readable media for comparing word statistics between a significant amino acid sequence and a significant nucleotide sequence.. .
University Of Delaware


07/14/16
20160202267 

Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides


The invention relates to a method for obtaining april-binding peptides. With this method april-binding peptides may be obtained and/or selected.
Aduro Biotech Holdings, Europe B.v.


07/14/16
20160202249 

Method for measuring modified nucleobase using absorbent polynucleotide and kit for same


An object of the present invention is to provide a technique that suppresses a background value of a detection signal to construct an immunoassay system for detecting a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample and a capture probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the presence of an absorbent polynucleotide in the obtained solution.
Fujirebio Inc.


07/14/16
20160201147 

Analysis of polynucleotides


According to some embodiments herein, methods and kits for labeling and analyzing nucleic acids are provided. In some embodiments, sequence-specific labeling is performed on polynucleotide sequences associated with a host genome, and the presence or absence of patterns characteristic of extragenomic sequences are determined..
Bionano Genomics, Inc.


07/14/16
20160201146 

Novel reporter constructs for compound screening


The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a dna sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the dna sequence-specific transactivator.
Koch Biological Solutions, Llc


07/14/16
20160201145 

Marker associated with anthracnose resistance in plant of the genus fragaria and use thereof


This invention is intended to develop many dna markers in plants of the genus fragaria and to evaluate anthracnose resistance with high accuracy with the use of such many dna markers. The markers associated with anthracnose resistance in plants of the genus fragaria each comprise a continuous nucleic acid region sandwiched between the nucleotide sequence as shown in seq id no: 1 and the nucleotide sequence as shown in seq id no: 10 in the chromosome of a plant of the genus fragaria..
Toyota Jidosha Kabushiki Kaisha


07/14/16
20160201134 

Noninvasive prenatal diagnosis of fetal trisomy by allelic ratio analysis using targeted massively parallel sequencing


Whether a fetus has an aneuploidy associated with a first chromosome is detected using ratios of alleles detected in a maternal sample having a mixture of maternal and fetal dna. Dna from the sample is enriched for target regions associated with polymorphic loci and then sequenced.
The Chinese University Of Hong Kong


07/14/16
20160201130 

Macrophage migration inhibitory factor (mif) promoter polymorphism in inflammatory disease


Describe herein is a novel catt-tetranucleotide repeat polymorphism at position −817 of the human mif gene that functionally affects the activity of the macrophage inhibitory factor (mif) promoter in gene reporter assays. Four genotypes are described which comprise 5, 6, 7, or 8-catt repeat units.
Baxalta Gmbh


07/14/16
20160201127 

Methods and probes for monitoring marine water


A method of biomonitoring marine water is provided, as are probes and kits. The method comprises: extracting messenger ribonucleic acid (mrna) from mytilus species; preparing cdna from the mrna; hybridizing a plurality of probes with the cdna to provide a set of hybridized cdna, the probes consisting of at least 20 consecutive nucleotides of at least 50 sequences of seq id no: 1-122; and quantifying an abundance of the set of hybridized cdna, thereby biomonitoring marine water..

07/14/16
20160201126 

Efficient biomolecule recycling method and system


A technique is disclosed for recapturing and recycling biomolecule reagents. The technique may be applied in a range of settings, including biopolymer synthesis, sequencing, and so forth.
Illumina, Inc.


07/14/16
20160201124 

Targeted sequencing and uid filtering


Provided herein are methods, compositions, and kits for targeted sequencing of polynucleotides with high accuracy and low amplification and sequencing errors.. .
Roche Molecular Systems, Inc.


07/14/16
20160201120 

Stable nanoreporters


The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to improved, stable nanoreporter probes that are capable of binding to and identifying target molecules based on the probes' uniquely detectable signal.
Nanostring Technologies, Inc.


07/14/16
20160201119 

Digital analysis of molecular analytes using electrical methods


Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte.
Apton Biosystems, Inc.


07/14/16
20160201118 

Nucleic acid calibration standards


The invention relates to synthetic nucleic acids and in particular, complementary pairs and their use as calibration standards for various techniques used to measure the interaction of biological molecules. The nucleotide sequence of the nucleic acids are non-naturally occurring and the single-stranded nucleic acids are essentially lacking in secondary structure, that is, the stability of hybridization between a single stranded nucleic acid and its complement is greater than any intra-strand pair binding.

07/14/16
20160201116 

Sequences and their use for detection of salmonella enteritidis and/or salmonella typhimurium


This invention relates to a rapid, accurate method for detection and characterization of salmonella enteritidis and/or salmonella typhimurium based on the presence of nucleic acid sequences, in particular, to a pcr-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect s.
E. I. Du Pont De Nemours And Company


07/14/16
20160201099 

Chimeric non-ribosomal peptide synthetase


The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a chimeric non-ribosomal peptide synthetase (nrps) fusion protein for the biosynthesis of n-acylglycine biosurfactants within a heterologous expression system.. .
Dow Agrosciences Llc


07/14/16
20160201085 

Enhancing efficiency of retroviral transduction of host cells


The present invention provides methods for enhancing transduction efficiency of a viral vector into a host cell such as an unstimulated stem cell. The methods involve transducing the host cell with the vector in the presence of an samhd1 inhibitor (e.g., a vpx protein), and an inhibitor of mtor complexes (e.g., rapamycin or analog compound thereof).
The Scripps Research Institute


07/14/16
20160201084 

Wheat ms1 polynucleotides, polypeptides, and methods of use


Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility.
Pioneer Hi Bred International Inc


07/14/16
20160201082 

Axmi422 toxin gene and methods for its use


Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
Athenix Corp.


07/14/16
20160201080 

Plant resistant to helminthosporium turcicum


The present invention provides an improved helminthosporium turcicum-resistant plant, in particular a maize plant which comprises a polynucleotide with one or more resistance-conferring genes, for example on a truncated chromosome fragment from the accession pepitilla, as well as a cell, a tissue, a part, grain and seeds thereof, an isolated polynucleotide which comprises one or more resistance-conferring genes against helminthosporium turcicum, a vector, a transgenic plant cell and a transgenic plant containing this polynucleotide. Furthermore, the invention encompasses suitable markers and their use in introducing resistance or the transgene into a plant, as well as the identification of improved maize plants which comprise a truncated chromosome fragment..
UniversitÄt ZÜrich


07/14/16
20160201079 

Polynucleotides and methods for making plants resistant to fungal pathogens


This invention relates to polynucleotide sequences encoding a gene that can confer resistance to the plant pathogen colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to the plant pathogen colletotrichum, and processes of making said plants and seeds.
University Of Delaware


07/14/16
20160201078 

Plants having increased tolerance to herbicides


The invention refers to plants comprising wild-type or mutated alopecurus ppo enzymes, and methods of obtaining such plants. The present invention further refers to a method for controlling weeds at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type or a mutated alopecurus ppo enzyme which is resistant or tolerant to a ppo-inhibiting herbicide by applying to said site an effective amount of said herbicide..
Basf Agro B.v.


07/14/16
20160201073 

Plant regulatory elements and methods of use thereof


The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for regulatory elements from petunia vein clearing virus.
E.i. Dupont De Nemours & Company


07/14/16
20160201072 

Genome modification using guide polynucleotide/cas endonuclease systems and methods of use


Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a cell or organism.
Pioneer Hi-bred International, Inc.


07/14/16
20160201070 

Method for expanding color palette in dendrobium orchids


A nucleotide sequence encoding flavonoid 3′-hydroxylase (f3′h) of dendrobium, a method of producing a transgenic flower color-changed dendrobium plant, and a transgenic flower color-changed dendrobium plant are provided by this invention.. .
University Of Dubuque


07/14/16
20160201067 

Composition for enhancing transgene expression in eukaryotic cells and enhancing production of a target protein encoded by a transgene


Production of dna vectors with the inserted gene of a target protein and the production of recombinant protein in eukaryotic cell cultures is disclosed. A composition for the intensive production of target protein in eukaryotic cells comprises a dna vector with the inserted gene of a target protein and an agonist of cell receptors belonging to the pattern recognition receptor (prr) family selected from the following agonists: tlr2, or tlr4, or tlr5, or tlr7, or tlr8, or tlr9, or nod1 receptor, or nod2 receptor, used in an optimal ratio.
Silezia Group Pte. Ltd


07/14/16
20160201065 

Methods and compositions for selecting sirna of improved functionality


Efficient sequence specific gene silencing is possible through the use of sirna technology. Be selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Thermo Fisher Scientific Inc.


07/14/16
20160201061 

Antisense-based small rna agents targeting the gag open reading frame of hiv-1 rna


Antisense nucleic acid molecules, such as ribozymes, shrna and sirna, targeting the gag region of hiv-1 open reading frame, and uses thereof for inhibiting hiv-1 replication and infection, are disclosed. The antisense nucleic acid molecules more specifically target a sequence corresponding to about nucleotide 1495 to about nucleotide 1526, or nucleotide 1497 to about nucleotide 1521, of hiv-1 clone pnl4-3..
The Royal Institution For The Advancement Of Learning/mcgill University


07/14/16
20160201060 

Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response


The invention provides immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit tlr-mediated signaling in response to a tlr ligand or tlr agonist.
Idera Pharmaceuticals, Inc.


07/14/16
20160201059 

Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells


In some embodiments, aptamers that specifically bind pancreatic cancer cells are provided. Such aptamers may include an rna molecule that specifically binds a pancreatic cancer cell surface protein.
City Of Hope


07/14/16
20160201058 

Methods and compositions for selecting sirna of improved functionality


Efficient sequence specific gene silencing is possible through the use of sirna technology. By selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Thermo Fisher Scientific Inc.


07/14/16
20160201054 

Method of obtaining antibodies of interest and nucleotides encoding same


The invention is a methodology which makes it possible to select from a very large number of cells, a single cell or cells of interest and obtain specific information from those cells in a rapid and efficient manner. As an example of the methodology, a large number of antibody producing cells such as plasma cells are separated so that these individual antibody producing plasma cells are placed in individual wells.
Single Cell Technology, Inc.


07/14/16
20160201048 

Stabilized recombinant expression plasmid vector in hafnia alvei and applications thereof


One aspect of the present disclosure relates to a stabilized recombinant expression plasmid vector comprising a polynucleotide encoding an antitoxin gene which expresses a polypeptide that neutralizes a polypeptide toxic to a host cell, the toxic polypeptide being expressed by a toxin gene in the host cell, and a polynucleotide encoding a polypeptide expression product, and the stabilized recombinant expression plasmid vector is derived from a hafnia alvei autonomously replicable backbone plasmid. Other aspects of the present disclosure relate to a transformant transformed with the stabilized recombinant expression plasmid vector disclosed herein, a method of producing biobased cadaverine using the transformant disclosed herein, and biobased cadaverine prepared by the method disclosed herein.
Cathay R&d Center Co., Ltd.


07/14/16
20160201046 

Degradable clostridial toxins


The specification discloses clostridial toxins or clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.. .
Allergan, Inc.


07/14/16
20160201044 

Novel insecticidal chitinase protein its encoding nucleotide and application thereof


A novel insecticidal chitinase protein from fern tectaria sp., a process for preparation of the insecticidal protein and nucleic acid sequence encoding for said insecticidal protein and its application for insect control purposes.. .
Council Of Scientific & Industrial Research


07/14/16
20160201042 

Alpha-amylase variants and polynucleotides encoding same


The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s






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