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Nucleotide

Nucleotide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Compressing, storing and searching sequence data
November 09, 2017 - N°20170323052

The redundancy in genomic sequence data is exploited by compressing sequence data in such a way as to allow direct computation on the compressed data using methods that are referred to herein as “compressive” algorithms. This approach reduces the task of computing on many similar genomes to only slightly more than that of operating on just ...
Nano-plasmonic molecular probes for plasmonics coupling interference
Duke University
November 09, 2017 - N°20170321280

Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include rna, dna, mrna, microrna, and small nucleotide polymorphisms (snps). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such ...
Methods and compositions for nucleic acid amplification
Gen-probe Incorporated
November 09, 2017 - N°20170321273

Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (tsu) promoter primer or promoter provider oligonucleotide that includes a target specific (ts) sequence that hybridizes specifically to a target sequence that is amplified and a universal (u) sequence that is introduced into the sequence that is amplified, by using a primer ...
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Method of determining the nucleotide sequence of oligonucleotides and dna molecules
Life Technologies Corporation
November 09, 2017 - N°20170321269

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of dna polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a dna fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base ...
Modified nucleotide reagents
Pacific Biosciences Of California, Inc.
November 09, 2017 - N°20170321268

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
The Trustees Of Columbia University In The City Of New York
November 09, 2017 - N°20170321267

This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.
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Nucleotide Patent Applications
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Probes for improved melt discrimination and multiplexing in nucleic acid assays
Luminex Corporation
November 09, 2017 - N°20170321259

Methods and compositions for the detection and quantification of nucleic acids are provided. In certain embodiments, methods involve the use of cleavable probes that comprise a ribonucleotide position that is susceptible to endoribonuclease (e. G., rnase h) cleavage in the presence of target nucleic acid molecules. Probes of the embodiments may also comprise non-natural nucleotide linked to a reporter and/...
Bacterial pathogen identification by high resolution melting analysis
The Board Of Trustees Of The Leland Stanford Junior University
November 09, 2017 - N°20170321257

Methods and oligonucleotide reagents for identification of bacteria by high resolution melting (hrm) analysis are described. In particular, the invention relates to hrm analysis of hypervariable bacterial genomic dna of the internal transcribed spacer (its) region for fingerprinting eubacterial pathogens.
Cancer marker and cancer determination method
Wako Pure Chemical Industries, Ltd.
November 09, 2017 - N°20170321247

The invention relates to a cancer marker, consisting of a portion of or all of the nucleotide sequence represented by seq id no: 1 in a foxb2 gene derived from a cell, and being continuous nucleotide sequences comprising at least the nucleotide sequence represented by seq id no: 2 or 3, wherein 30% or more of cytosines of the -cg- sequences present in said ...
Presentation of bioactive proteins
Indiana University Research And Technology Corporation
November 09, 2017 - N°20170321220

The invention provides a fusion protein comprising an antigen binding domain linked to a bacteriophage decoration (dec) protein along with a polynucleotide comprising the nucleic acid sequence of the fusion protein and a vector comprising the polynucleotide. Additionally, the invention provides a composition comprising the fusion protein and a virus-like particle (vlp), and a method of treating a disease in ...
Oligonucleotide compositions with enhanced efficiency
Life Technologies Corporation
November 09, 2017 - N°20170321219

The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.
Antisense oligonucleotide for splicing adjustment of mutant dopa decarboxylase gene and using method thereof
Taichung Veterans General Hospital
November 09, 2017 - N°20170321217

This present invention discloses an antisense oligonucleotide for splicing adjustment of mutant dopa decarboxylase gene which is complementary to seq id no: 1. This antisense oligonucleotide can modulate alternative splicing site of mutant dopa decarboxylase gene. It is helpful to research and develop drug to treat aadc deficiency symptom. This present invention also discloses a method to use said antisense oligonucleotide ...
Whole genome mapping by dna sequencing with linked-paired-end library
Drexel University
November 09, 2017 - N°20170321211

The present invention relates to innovative means of generating sequence-linked dna fragments and subsequent uses of such linked dna fragments for de novo haplotype-resolved whole genome mapping and massively parallel sequencing. In various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, ...
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Nucleotide Patent Applications
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Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
Pangu Biopharma Limited
November 09, 2017 - N°20170321206

Provided are compositions comprising newly identified protein fragments of aminoacyl-trna synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Penicillin-g acylases
Codexis, Inc.
November 09, 2017 - N°20170321202

The present invention provides engineered penicillin g acylase (pga) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
Polypeptides having endoglucanase activity and polynucleotides encoding same
Novozymes Inc.
November 09, 2017 - N°20170321200

The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Alicyclobacillus variants and polynucleotides encoding same
Novozymes A/s
November 09, 2017 - N°20170321199

The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
Lipase variants and polynucleotides encoding same
Novozymes A/s
November 09, 2017 - N°20170321197

The present invention relates to a variant of a parent lipase, which parent lipase has the amino acid sequence of seq id no: 2, wherein the variant has lipase activity, comprises a substitution at a position corresponding to position 51 and comprises a substitution or remains unaltered at a position corresponding to position 96 of seq id no: 2. The present invention also relates ...
Humanized monoclonal antibody and uses thereof
Industrial Technology Research Institute
November 09, 2017 - N°20170320966

A humanized monoclonal antibody against the cd34 surface antigen is provided in the present disclosure. The humanized monoclonal antibody includes a light chain variable region and a heavy chain variable region. In which, a nucleotide sequence encoding the amino acid sequence for the light chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of seq id ...
Antibodies, variable domains & chains tailored for human use
Kymab Limited
November 09, 2017 - N°20170320936

The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, ...
Methods of producing a zcytor17 heterodimeric cytokine receptor
Zymogenetics, Inc.
November 09, 2017 - N°20170320931

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods ...
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