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Nucleotide

Nucleotide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method of screening a drug such as insulin secretagogue
Jnc Corporation
January 11, 2018 - N°20180011082

The screening method of the present invention is useful for screening drugs such as insulin secretagogues having an insulin secretagogue activity with minimized side effects (hypoglycemia induction, etc.). The transformant in which a polynucleotide encoding the fusion protein used for the screening method is introduced, the screening kit comprising the transformant, etc. Are also useful for screening excellent drugs.
Genetic variant of the annexin a5 gene
Universitaetsklinikum Muenster
January 11, 2018 - N°20180010190

The present invention relates to a nucleic acid molecule comprising an annexin a5 (anxa5) gene regulation element which comprises at least one point mutation, whereby said at least one point mutation (substitution) is selected from the group consisting of (i) a point mutation g to a at a position which corresponds to nucleotide 186 of seq id no: 2; (ii) a point ...
Methods and systems for sequencing long nucleic acids
Centrillion Technology Holdings Corporation
January 11, 2018 - N°20180010180

The present invention provides methods and systems for sequencing long nucleic acid fragment. The present invention also provides a method of sequencing a target polynucleotide with fewer probes. Further, the present invention provides a method of sequencing a target polynucleotide with longer reads. Locus-specific, ligation-assisted sequencing/genotyping method and ligation-captured sequencing method are also provided in the present invention. The ...
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Nucleotide Patent Applications
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Novel dna-binding proteins and uses thereof
Sangamo Therapeutics, Inc.
January 11, 2018 - N°20180010152

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel dna-binding domains, including tale dna-binding domains. Also disclosed are methods of using these novel dna-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
Regulation of gene expression by aptamer-mediated modulation of alternative splicing
Meiragtx Uk Ii Limited
January 11, 2018 - N°20180010146

The invention provides a platform and methods of using the platform for the regulation of the expression of a target gene using exposure to an aptamer ligand (for example, a small molecule). The platform features a polynucleotide gene regulation cassette that is placed in the target gene and includes a synthetic riboswitch positioned in the context of a 5′ intron-alternative ...
Manipulation of dominant male sterility
Pioneer Hi-bred International, Inc.
January 11, 2018 - N°20180010145

Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and fragments and variants thereof, which modulate male fertility. Further provided are expression cassettes comprising the male fertility polynucleotides, or fragments or variants thereof, operably linked to a promoter, wherein expression of the polynucleotides modulates the male fertility of a plant. Various methods are ...
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Nucleotide Patent Applications
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  • 1871+ full patent PDF documents of Nucleotide-related inventions.
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Production of fatty acid derivatives
Reg Life Sciences, Llc
January 11, 2018 - N°20180010137

The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than ...
Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo
Curna, Inc.
January 11, 2018 - N°20180010131

Oligonucleotide compounds modulate expression and/or function of erythropoietin (epo) polynucleotides and encoded products thereof. Methods for treating diseases associated with erythropoietin (epo) comprise administering one or more oligonucleotide compounds designed to inhibit the epo natural antisense transcript to patients.
Antisense compounds and uses thereof
Ionis Pharmaceuticals, Inc.
January 11, 2018 - N°20180010126

The present disclosure provides oligomeric compounds. The present disclosure provides metabolically stable linkers that do not rapidly degrade in vivo. In certain embodiments, the present disclosure provides metabolically stable linkers for use in attaching a conjugate group to an oligonucleotide.
Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof
Quark Pharmaceuticals Inc.
January 11, 2018 - N°20180010125

Provided herein are double stranded nucleic acid molecules, compositions comprising same and methods of use thereof for the treatment of a subject wherein expression of ddit4 is associated with the etiology or progression of a disease or disorder in the subject. The compounds are preferably chemically synthesized and modified dsrna molecules.
Compositions and methods for preparing oligonucleotide solutions
Illumina, Inc.
January 11, 2018 - N°20180010123

The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in solution. The pool of oligonucleotides finds use in a variety of nucleic acid detection and/or amplification assays.
Targeted treatment of leber congenital amourosis
Sangamo Therapeutics, Inc.
January 11, 2018 - N°20180010117

Disclosed herein are methods and compositions for inactivating mutant genes associated with lca, using engineered nucleases comprising a dna binding domain and a cleavage domain or cleavage half-domain in conditions promoting the cleavage of the mutant genes. Polynucleotides encoding nucleases, vectors comprising polynucleotides encoding nucleases, and cells comprising polynucleotides encoding nucleases and/or cells comprising nucleases are also provided.
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Novozymes, Inc.
January 11, 2018 - N°20180010112

The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
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Nucleotide Patent Applications
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inventor
  • 1871+ full patent PDF documents of Nucleotide-related inventions.
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Toolkit for the production of post-translationally modified proteins
Washington University
January 11, 2018 - N°20180010102

The present disclosure provides a system to produce soluble, folded, and post-translationally modified proteins. The system includes a fusion protein comprising a catalytic domain of an enzyme involved in post-translational protein modification and a targeting domain, and a substrate protein comprising a protein of interest and a sequence that interacts with the targeting domain. The present disclosure also provides polynucleotide ...
Herbicide-resistant rice plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use
Instituto Nacional De Tecnologia Agropecuaria
January 11, 2018 - N°20180010101

Herbicide-resistant rice plants, isolated polynucleotides that encode herbicide resistant and wild-type acetohydroxy-acid synthase large subunit 1 (ahasl1) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described. Methods of using the polynucleotides to enhance the resistance ...
Biocatalysts for the preparation of hydroxy substituted carbamates
Codexis, Inc.
January 11, 2018 - N°20180010100

The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.
Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3'-utr of dengue types 1, 2, 3, and 4, ...
The United States Of America,as Represented By The Secretary, Department Of Helath And Human Service
January 11, 2018 - N°20180010099

The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3′-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.
Anti-ror1 antibodies
Eureka Therapeutics, Inc.
January 11, 2018 - N°20180009892

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for receptor tyrosine kinase-like orphan receptors (ror), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and ...
Method and compositions for cellular immunotherapy
Seattle Children's Hospital (dba Seattle Children's Research Institute)
January 11, 2018 - N°20180009891

The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring cd8+ central memory t cells or combinations of central memory t cells with cd4+ t cells that are genetically modified to express a chimeric receptor. In some alternatives the genetically modified host ...
Interleukin-2 fusion proteins and uses thereof
Roche Glycart Ag
January 11, 2018 - N°20180009868

The present invention generally relates to fusion proteins of immunoglobulins and interleukin-2 (il-2). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.
Alternative nucleic acid molecules containing reduced uracil content and uses thereof
Modernatx, Inc.
January 11, 2018 - N°20180009866

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mrna wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, ...
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