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Nucleotide patents



      
           
This page is updated frequently with new Nucleotide-related patent applications. Subscribe to the Nucleotide RSS feed to automatically get the update: related Nucleotide RSS feeds. RSS updates for this page: Nucleotide RSS RSS


Date/App# patent app List of recent Nucleotide-related patents
02/26/15
20150059018
 Methods and compositions for producing drimenol patent thumbnailnew patent Methods and compositions for producing drimenol
The present invention relates to nucleic acids sequences derived from valeriana officinalis and/or persicaria hydropiper and encoding drimenol synthase polypeptides. The present invention also provides the amino acid sequences of the polypeptides.
Keygene N.v.
02/26/15
20150059014
 Polynucleotides and polypeptides in plants patent thumbnailnew patent Polynucleotides and polypeptides in plants
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
Mendel Biotechnology, Inc.
02/26/15
20150059010
 Genome modification using guide polynucleotide/cas endonuclease systems and methods of use patent thumbnailnew patent Genome modification using guide polynucleotide/cas endonuclease systems and methods of use
Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide polynucleotide/cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a cell or organism.
Pioneer Hi-bred International Inc
02/26/15
20150057373
 Diether based biodegradable cationic lipids for sirna delivery patent thumbnailnew patent Diether based biodegradable cationic lipids for sirna delivery
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. The cationic lipids can demonstrate enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver.
Sirna Therapeutics, Inc
02/26/15
20150057338
 Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene patent thumbnailnew patent Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a pancreatic developmental gene, in particular, by targeting natural antisense polynucleotides of a pancreatic developmental gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of pancreatic developmental genes..
Curna, Inc.
02/26/15
20150057335
 Novel fusion genes identified in lung cancer patent thumbnailnew patent Novel fusion genes identified in lung cancer
[means for solving] a method for detecting a gene fusion serving as a responsible mutation (driver mutation) for cancer, the method comprising the step of detecting any one of an ezr-erbb4 fusion polynucleotide, a kiaa1468-ret fusion polynucleotide, a trim24-a braf fusion polynucleotide, a cd74-nrg1 fusion polynucleotide, and an slc3a2-nrg1 fusion polynucleotide, or a polypeptide encoded thereby, in an isolated sample from a subject with cancer.. .
02/26/15
20150057333
 Double-stranded oligonucleotides patent thumbnailnew patent Double-stranded oligonucleotides
Antisense sequences, including duplex rnai compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically.
Life Technologies Corporation
02/26/15
20150057330
 Antisense oligonucleotides for inducing exon skipping and methods of use thereof patent thumbnailnew patent Antisense oligonucleotides for inducing exon skipping and methods of use thereof
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in seq id no: 1 to 202.. .
The University Of Western Australia
02/26/15
20150057329
 Compounds and methods for modulating expression apob patent thumbnailnew patent Compounds and methods for modulating expression apob
The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index.
Isis Pharmaceuticals, Inc.
02/26/15
20150057317
 Gabr-a2 diagnostic patent thumbnailnew patent Gabr-a2 diagnostic
The present invention provides a method of selection of a patient, who is a candidate for treatment with an nmda antagonist drug, such as (s)-1-phenyl-2-(pyridin-2-yl)ethanamine or ketamine, whereby to predict an increased or decreased likelihood of response to the nmda antagonist. The invention provides a method for determining the sequence of gabr-a2 at any of four single nucleotide polymorphism (snp) sites known as rs3756007, rs11503016, rs17537359 or rs1372472.
Astrazeneca Ab
02/26/15
20150057182
new patent

Methods for analysis of dna fragments


A method of genotyping includes applying a sample solution including a plurality of copies of a sample polynucleotide to an array of sensors. The sample polynucleotide includes a region associated with an allele.
Life Technologies Corporation
02/26/15
20150057179
new patent

Methods and compositions for hte diagnosis and treatment of thyroid cancer


Methods for detecting thyroid cancer or thyroid cancer status in a subject are described comprising measuring novel markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for thyroid cancer, and kits for carrying out the methods of the invention.
02/26/15
20150057171
new patent

Oligonucleotides and methods for determining a predisposition to soft tissue injuries


A method of determining in a subject a predisposition to, or increased risk for, developing a tendon, ligament, or other soft tissue injury or pathology, the method comprising the step of screening the subject for the presence of at least one polymorphism in at least one gene selected from the group comprising: a) the collagen v gene col5a1; wherein the col5a1 gene is rs71746744, rs16399 and/or rs1134170 within the 3′-untranslated region (utr) of the alpha 1 chain of the col5a1 gene; b) the mir608 gene which encodes a mirna which binds to a recognition sequence within the 3′-utr of the collagen v gene col5a1; and c) the casp8 gene; wherein the presence of the polymorphism is indicative of a predisposition to, or increased risk for, developing a musculoskeletal soft tissue injury in the subject.. .
University Of Cape Town
02/26/15
20150057169
new patent

Biomarkers for head-and-neck cancers and precancers


The invention provides markers and methods for detecting head-and-neck precancers, (including opls), cancers and related disease conditions in a subject. The invention also provides localization and imaging methods for head-and-neck precancers (including opls) and cancers, along with kits for carrying out methods of the invention.
02/26/15
20150057164
new patent

High throughput methods for functionally determining rna interference efficiency


Provided is a single construct combining a sequence encoding an rnai molecule, a sequence encoding a reporter, and a target sequence specific for the rnai molecule. The construct can be used to determine the potency of the encoded rnai molecule in a direct and unbiased way.
Cold Spring Harbor Laboratory
02/26/15
20150056680
new patent

Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses


The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor.
Ibc Pharmaceuticals, Inc.
02/26/15
20150056670
new patent

Microorganism producing 4-hydroxybutyrate and a producing 4-hydroxybutyrate in anaerobic condition using the same


A genetically modified microorganism comprising a polynucleotide encoding α-ketoglutarate synthase or a mutant thereof, and a polynucleotide encoding pyruvate carboxylase or a mutant thereof; wherein the genetically modified microorganism has decreased malate quinone oxidoreductase activity and/or decreased phosphoenolpyruvate carboxykinase activity compared to an unmodified microorganism of the same type, and wherein the genetically modified microorganism produces 4-hydroxybutyrate.. .
Samsung Electronics Co., Ltd.
02/26/15
20150056668
new patent

Synthesis of prazole compounds


The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.. .
Codexis, Inc.
02/26/15
20150056666
new patent

Variants of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase


The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.. .
Evonik Degussa Gmbh
02/26/15
20150056664
new patent

Variants of glycoside hydrolases


The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of seq id no: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of seq id no: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of seq id no: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences..
Novozymes Inc.
02/26/15
20150056656
new patent

Method for reduction of 1->2 reading frame shifts


Herein is reported a method for the recombinant production of a polypeptide, which comprises the dipeptide ar, characterized in that the method comprises the recovering of the polypeptide from the cells or the cultivation medium of a cultivation of a cell comprising a nucleic acid encoding the polypeptide and thereby producing the polypeptide, whereby the dipeptide ar comprised in the polypeptide is encoded by the oligonucleotide gca cgt, or the oligonucleotide gcg cgt, or the oligonucleotide gcc cgt.. .
Hoffmann-la Roche Inc.
02/26/15
20150056627
new patent

Aptamers


A nucleic acid aptamer comprising the nucleotide sequence shown herein as seq id no. 5, 6, 7, 8, 9, 10, 1, 2, 3 or 4 or a fragment thereof or a sequence which is at least 80% identical therewith and use of nucleic aptamers to detect the presence of pathogenic bacteria in a sample, particularly in a complex matrix—such as a food system..
The University Of Chester
02/26/15
20150056623
new patent

Oligonucleotide primer with omega structure for detecting short-chain rnas and use thereof


Disclosed are an oligonucleotide primer with an omega structure for detecting short-chain rnas and the use thereof. The primer from the 5′ end to the 3′ end sequentially is: a pcr primer target region of 20-30 bases, a variable coding region of 0-50 bases, an omega stem-loop, a probe spacer of at least one base and a probe region of 4-11 bases.
Chengdu Nuoen Biological Technology Co., Ltd
02/26/15
20150056245
new patent

Recombinant inactivated viral vector vaccine


A vaccine is described, comprising an inactivated viral vector having inserted an exogenous nucleotide sequence coding for a disease of concern; and, a pharmaceutically acceptable vehicle, adjuvant or excipient, which provides due protection against the disease of concern by using a viral vector titer similar to that required for an active-virus vaccine based on the same viral vector. Mainly, viral vectors of paramixovirus or adenovirus are described..
Laboratorio Avi-mex, S.a. De C.v.
02/26/15
20150056243
new patent

Multicomponent or monocomponent vaccine to be used against chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure


A vaccine against the chagas disease, capable of stimulating the immune response against the trans-sialidase virulence factor of the trypanosoma cruzi parasite, which is a multicomponent vaccine comprising: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions codifying one or more immunogenic polypeptides, or a monocomponent vaccine comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions codifying one or more immunogenic polypeptides derived from trypanosoma cruzi and pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.. .
02/26/15
20150056236
new patent

An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof


The invention provides isolated polynucleotide molecules that comprise a dna sequence encoding an infectious rna sequence encoding a genetically-modified north american prrs virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of north american prrs virus. The invention also provides vaccines comprising genetically modified north american prrs virus, rna molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules.
Zoetis Llc
02/26/15
20150056230
new patent

Equine encephalitis virus vaccines and methods of using thereof


Disclosed herein are nucleotide sequences which encode a plurality of structural proteins, except the capsid, of an equine encephalitis virus, wherein the nucleotide sequence is codon-optimized for mammalian expression. The nucleotide sequences are codon-optimized for expression in humans.
02/26/15
20150056224
new patent

Compositions and methods for activating stimulator of interferon gene-dependent signalling


The present invention provides highly active cyclic-di-nucleotide (cdn) immune stimulators that activate dcs via a recently discovered cytoplasmic receptor known as sting (stimulator of interferon genes). In particular, the cdns of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce sting-dependent type i interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2′,5′,2′,5′ and 2′,5′,3′,5′ cdns, and preferably rp,rp stereosiomers thereof..
The Regents Of The University Of California
02/26/15
20150056193
new patent

Egfr and ros1 kinase in cancer


The present disclosure provides methods of that include detecting in a biological sample from a patient having or suspected of having cancer the presence of a polypeptide having ros1 kinase activity or a polynucleotide encoding the same and detecting in the biological sample the presence of a mutant egfr polypeptide or a polynucleotide encoding the same. In some aspects, the disclosure provides methods of treating a patient for cancer that include determining that a biological sample from a tumor in the patient includes a polypeptide having ros1 kinase activity or a polynucleotide encoding the same and a mutant egfr polypeptide or a polynucleotide encoding the same and administering to the patient a therapeutically effective amount of a ros1 inhibitor and an egfr inhibitor, thereby treating the patient for cancer..
Cell Signaling Technology, Inc.
02/26/15
20150056178
new patent

Modified beta-lactamases and methods and uses related thereto


Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.. .
02/26/15
20150056134
new patent

Nucleic acids encoding human antibodies to sialyl-lewis a


The present invention provides compositions for the production of an antibody or functional fragment thereof directed against sialyl-lewisa (slea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to slea.
Mabvax Therapeutics, Inc.
02/26/15
20150055132
new patent

Method for calibrating spectroscopy apparatus and equipment for use in the method


This invention concerns a method of calibrating spectroscopy apparatus including illuminating a reference sample, identifying spectrum from light emitted from the sample and calibrating the spectroscopy apparatus based upon the spectrum, wherein the reference sample has been dried. The invention also concerns a reference sample for use in this method and a kit including such a reference sample.
Renishaw Diagnostics Limited
02/19/15
20150052643

Compositions and methods for insecticidal control of stinkbugs


Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pentatomidae plant pest or a n. Viridula, acrosternum hilare, piezodorus guildini, and/or halymorpha halys plant pest, decrease the expression of a target sequence in the pest.
E I Du Pont De Nemours And Company
02/19/15
20150052633

Mutation of the ear motif of class ii hd-zip polypeptides


The application describes producing polynucleotide variants of the athb 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the ear motifs..
Mendel Biotechnology, Inc.
02/19/15
20150052631

Stalk-length-related marker derived from genome of wild-type sugarcane and use thereof


The invention provides a marker related to quantitative traits of a gramineae plant, and in particular, stalk length. Such gramineae stalk-length-related marker comprises a continuous nucleic acid region selected from a region sandwiched between the nucleotide sequence shown in seq id no: 1 and the nucleotide sequence shown in seq id no: 2 of a chromosome of the gramineae plant..
Toyota Jidosha Kabushiki Kaisha
02/19/15
20150051220

Compounds for use in therapy


For use in the treatment of a condition or disorder associated with nicotinamide adenine dinucleotide phosphate oxidase.. .
02/19/15
20150051167

Substituted nucleosides, nucleotides and analogs thereof


Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof..
Alios Biopharma, Inc.
02/19/15
20150051113

Nucleotide analogs


Provided herein is technology relating to the manipulation and detection of nucleic acids, including but not limited to compositions, methods, and kits related to nucleotides comprising a chemically reactive linking moiety.. .
Abbott Molecular Inc.
02/19/15
20150051099

Methods of constructing small rna libraries and their use for expression profiling of target rnas


Methods, compositions, and kits comprising target-specific oligonucleotides (tsos) are disclosed herein. Methods, compositions, and kits comprising target-specific oligonucleotides (tsos) can be used to attach adapters and/or linkers to target rnas.
Somagenics, Inc.
02/19/15
20150051083

Methods and compositions for identifying repeating sequences in nucleic acids


Short tandem repeats are currently used by law enforcement and others, for example, for the identification of individuals by dna matching. A method is described herein that uses wpd to classify and identify repeating sequences in nucleotide sequences from the position and frequency information contained within nucleotide sequences.
Battelle Memorial Institute


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This listing is a sample listing of patent applications related to Nucleotide for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleotide with additional patents listed. Browse our RSS directory or Search for other possible listings.
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