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Nucleotide patents

      

This page is updated frequently with new Nucleotide-related patent applications.




 High-resolution melting analysis patent thumbnailHigh-resolution melting analysis
The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. Methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample.
Canon U.s. Life Sciences, Inc.


 Peptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides patent thumbnailPeptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides
The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of basic proline-rich lacrimal protein (bplp) or of any of its maturation products, by detecting, or quantifying in a biological sample of a test subject, a bplp protein or a maturation product thereof, and comparing the production of bplp protein or maturation product with the production of the same in a biological sample of a control subject. .
Institut Pasteur


 Detecting single nucleotide polymorphism using overlapping hydrolysis probes patent thumbnailDetecting single nucleotide polymorphism using overlapping hydrolysis probes
Methods for the rapid detection of the presence or absence of a snp in a target nucleic acid in a sample are described. The methods can include performing an amplifying step, a hybridizing step utilizing a double stranded probe with two overlapping snp specific hydrolysis probe sequences where one of the probe sequences can include a hairpin structure toward the 3′ end, and a detecting step.
Roche Molecular Systems, Inc.


 Targeted gene delivery for dendritic cell vaccination patent thumbnailTargeted gene delivery for dendritic cell vaccination
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (dc). The virus envelope comprises a dc-sign specific targeting molecule.
California Institute Of Technology


 Enhanced nucleic acid constructs for eukaryotic gene expression patent thumbnailEnhanced nucleic acid constructs for eukaryotic gene expression
The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors further comprise novel transposons and transposases that further improve expression.
Dna2.0, Inc.


 Nov mini-promoters patent thumbnailNov mini-promoters
Isolated polynucleotides comprising a nov mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, including, but not limited to, reporter genes, genes encoding a polypeptide of interest, and regulatory rna sequences such as mirna, sirna, and anti-sense rna.
The University Of British Columbia


 Sorghum-derived transcription regulatory elements predominantly active in root hair cells and uses thereof patent thumbnailSorghum-derived transcription regulatory elements predominantly active in root hair cells and uses thereof
Transcription regulatory elements, namely promoter and terminator sequences, obtained from sorghum bicolor that drive rna transcription predominately in root hair cells are described, as well as cassettes, expression vectors, and genetically modified plants containing these transcription regulatory elements. The genetically modified plants can be gymnosperms, dicots, or monocots.
The United States Of America, As Represented By The Secretary Of Agriculture


 Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf patent thumbnailTreatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
Oligonucleotide compounds modulate expression and/or function of vascular endothelial growth factor (vegf) polynucleotides and encoded products thereof. Methods for treating diseases associated with vascular endothelial growth factor (vegf) comprise administering one or more oligonucleotide compounds designed to inhibit the vegf natural antisense transcript to patients..
Curna, Inc.


 Peptides derived from gse 24.2 for treating diseases caused by oxidative stress and damage to dna patent thumbnailPeptides derived from gse 24.2 for treating diseases caused by oxidative stress and damage to dna
This invention relates to a polypeptide which comprises the fragment seq id no. 2 of peptide gse24.2 (seq id no.
Centro De InvestigaciÓn BiomÉdica En Red (ciber)


 Delivery of packaged rna to mammalian cells patent thumbnailDelivery of packaged rna to mammalian cells
Described herein are compositions relating to alphavirus-based virus-like particles (vlps) and methods for making and using the described vlps. The described compositions include vlps and vectors and cells used to produce the vlps.
The Usa , As Represented By The Secretary, Dept. Of Health And Human Services


Interleukin-10 fusion proteins and uses thereof

The present invention generally relates to fusion proteins of antibodies and interleukin-10 (il-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides.
Roche Glycart Ag

Rna monomers containing o-acetal levulinyl ester groups and their use in rna microarrays

The present invention is directed to rna monomers comprising o-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or rna polynucleotides.
Wisconsin Alumni Research Foundation

Method for purifying reduced form of beta-nicotinamide adenine dinucleotide

The present invention discloses a method for purifying reduced form of β-nicotinamide adenine dinucleotide, comprising the steps of: sequentially microfiltrating and nanofiltrating a reaction solution obtained after an enzymatic reaction, to collect a concentrate for use; then adding an ion pair reagent to the concentrate, and purifying by gradient elution using a reverse-phase chromatographic column as a stationary phase, a buffer solution as a phase a, and ethanol as a phase b; changing the cations in the purified filtrate into sodium ions by using a cation exchange resin; and nanofiltrating the filtrate obtained in step c, and finally freeze drying it in a vacuum freeze drier. In the present invention, the reduced form of β-nicotinamide adenine dinucleotide is purified by reverse phase high performance liquid chromatography and cation exchange, such that the reduced form of β-nicotinamide adenine dinucleotide has a high purity and high yield, thus meeting the requirements in industry..
Bontac Bio-engineering (shenzhen) Co., Ltd

Method for purifying oxidized form of beta-nicotinamide adenine dinucleotide phosphate

The present invention discloses an oxidized form of β-nicotinamide adenine dinucleotide phosphate and a method for purifying the same. The method comprises specifically the steps of: a.
Bontac Bio-engineering (shenzhen) Co., Ltd

Method for purifying oxidized form of beta-nicotinamide adenine dinucleotide

The present invention discloses a method for purifying oxidized form of β-nicotinamide adenine dinucleotide, comprising the steps of: sequentially microfiltrating and nanofiltrating a reaction solution obtained after an enzymatic reaction by using filteration membranes, to collect a concentrate for use; then adding an acid to the concentrated filtrate, to adjust the ph of the concentrate, and purifying by gradient elution using a reverse-phase chromatographic column as a stationary phase, a buffer solution as a phase a, and ethanol as a phase b; and concentrating the purified solution by nanofiltrating it with a filtration membrance, and then freeze drying it in a vacuum freeze drier. In the present invention, the oxidized form of β-nicotinamide adenine dinucleotide is purified by reverse phase high performance liquid chromatography, such that the oxidized form of β-nicotinamide adenine dinucleotide has a high purity and high yield, thus meeting the requirements in industry..
Bontac Bio-engineering (shenzhen) Co., Ltd

Integrated active flux microfluidic devices and methods

The invention relates to a microfabricated device for the rapid detection of dna, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g.
California Institute Of Technology

De novo synthesized gene libraries

De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein.
Twist Bioscience Corporation

Wound healing compositions and treatments

This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase..
Coda Therapeutics, Inc.

Novel alternative splicing variant of oatp1b3 mrna

According to the present invention, a method for measuring an alternative splicing variant of oatp1b3 mrna in a sample to be examined is provided. Said measurement method comprises measuring mrna comprising a nucleotide sequence represented by seq id no: 1 in the sequence listing table in a sample to be examined isolated from living organism with differentiation from a mrna comprising a nucleotide sequence represented by seq id no: 2.

Gene defects and mutant alk kinase in human solid tumors

Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of anaplastic lymphoma kinase (alk) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. Non-small cell lung carcinoma (nsclc).
Cell Signaling Technology, Inc.

Systems and methods to detect rare mutations and copy number variation

The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference.
Guardant Health, Inc.

Detecting cancer mutations and aneuploidy in chromosomal segments

The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus..
Natera, Inc.

Breast cancer prognostication and screening kits and methods of using same

A genetic biomarker panel is provided for prognosing late onset er+ breast cancer relapse, in a breast cancer survivor patient. Kits are also provided for measuring levels or the presence of an identified panel of genetic biomarkers.
Indiana University School Of Medicine

Methods of weight analysis and uses thereof

Disclosed herein are weight analysis methods and assays, which objectively identify biological strengths and weaknesses in a patient's genetic coding that affect their weight. The generated results can be utilized to develop a personalized weight and nutritional regimen to regulate weight and prevent, reduce and treat weight disorders and diseases.

Nucleic acid constructs and methods of use

The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired rois. Such validated rois and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like..
Prognosys Biosciences, Inc.

Microparticle containing nucleic acid capture probes and use

A method of identifying alleles of polymorphic sites in a plurality of nucleic acid samples including the steps of determining a source tag sharing number “d” for each of the alleles; performing a first reaction in a plurality of pools of the alleles to be identified to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products to identify the alleles. If “d” is equal to or larger than a maximum pool size, the first reaction may not be performed.
Bioinventors & Entrepreneurs Network, Llc

Methods and products for transfecting cells

The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using rna are disclosed.
Factor Bioscience Inc.

Viral vector production system

The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an rna-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.. .
Oxford Biomedica (uk) Limited

Yield improvement in plants

Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased yield, increased light use efficiency, increased photosynthetic capacity, increased photosynthetic rate, increased photosynthetic resource use efficiency, greater vigor, and/or greater biomass as compared to a control plant..
Koch Biological Solutions, Llc

Nucleotide sequence encoding homeobox-leucine zipper protein hat22 (hd-zip protein 22) from corchorus olitorius and corchorus capsularis and methods of use

The present invention relates to the isolated polynucleotide encoding homeobox-leucine zipper protein hat22 (hd-zip protein 22) from the plants corchorus olitorius and corchorus capsularis and corresponding polypeptide derived thereof. The present invention also relates to the plants having modulated expression of a nucleic acid encoding a homeobox-leucine zipper hat22 polypeptide or a homologue thereof, which has the ability to modify, preferably to increase/enhance, the fiber length, plant height, and/or plant biomass.
Bangladesh Jute Research Institute

Saccharide-modified nucleic acid molecules

The present invention refers to the transfection of cells using a conjugate comprising at least one saccharide residue at least one nucleosidic component selected from nucleic acids, nucleosides and nucleotides. This conjugate is suitable for the transfection of prokaryotic and eukaryotic cells such as plant cells or mammalian cells including human cells with high efficacy.
Basf Se

Oligonucleotide modulators of the toll-like receptor pathway

Disclosed herein are double stranded nucleic acid molecules and pharmaceutical compositions comprising same useful in the treatment of, inter alia, acute and chronic inflammation, neuropathic pain, primary graft dysfunction (pgd) after lung transplantation in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsrna compounds, which down regulate or inhibit expression of toll like receptor 4..
Quark Pharmaceuticals, Inc.

5' triphosphate oligonucleotide with blunt end and uses thereof

The present invention provides an oligonucleotide which is capable of activating rig-i and inducing an anti-viral, in particular, an ifn, response in cells expressing rig-i. The present invention further provides an oligonucleotide which is capable of activating rig-i and which has target gene-silencing activity.
Rheinische Friedrich-wilhelms-universität Bonn

Bi-functional short-hairpin rna (bi-shrna) specific for single-nucleotide kras mutations

The present invention includes compositions and methods for making and using a bifunctional shrnas capable of reducing an expression of a k-ras gene, e.g., a mutated k-ras gene, wherein at least one target site sequence of the bifunctional rna molecule is located within the k-ras gene and wherein the bifunctional rna molecule is capable of activating a cleavage-dependent and a cleavage-independent rna-induced silencing complex for reducing the expression level of k-ras.. .
Strike Bio, Inc.

Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator

The present invention relates to an adjuvant which comprises oligonucleotides which comprise two to four sequences each represented by 5′-x1cpg x2-3′ and has a length of 14 to 32 nucleotides, wherein a nucleic acid at 3′ end side of at least two cpg motifs is connected by phosphorothioate linkage, wherein each nucleic acids at 3′ end and 5′ end of the oligonucleotide is s type nucleic acids connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. The present invention relates to an immunity-inducible activator comprising the adjuvant..

Altering microbial populations & modifying microbiota

The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use.
Snipr Technologies Limited

5' triphosphate oligonucleotide with blunt end and uses thereof

The present invention provides an oligonucleotide which is capable of activating rig-i and inducing an anti-viral, in particular, an ifn, response in cells expressing rig-i. The present invention further provides an oligonucleotide which is capable of activating rig-i and which has target gene-silencing activity.
Rheinische Friedrich-wilhelms-universität Bonn

Rack for sample tubes and reagent holders

A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples..
Handylab, Inc.

Variants of a family 44 xyloglucanase

The present invention relates to variants of a parent xyloglucanase. The present invention also relates to polynucleotides encoding the variant xyloglucanases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide..
Novozymes A/s

Enhanced nucleic acid constructs for eukaryotic gene expression

The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors further comprise novel transposons and transposases that further improve expression.
Dna2.0, Inc.

Conditionally replicating adenovirus

The present invention provides a polynucleotide, which comprises human telomerase reverse transcriptase (htert) promoter, e1a gene, ires sequence and e1b gene in this order and which comprises a target sequence of a first mirna. The present invention also provides a recombinant adenovirus, which comprises a replication cassette comprising the above polynucleotide, wherein the replication cassette is integrated into the e1 region of the adenovirus genome..

Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish

The present invention relates to a new generation of chimeric antigen receptors (car), under single-chain or multi-chain forms, the specificity of which, to a desired antigen, is conferred by a vnar polypeptide derived from monomeric antibodies from cartilaginous fish. Such cars, which aim to redirect immune cell specificity toward selected undesired malignant cells, are compact and thus particularly adapted to target hollow antigens such as ions channels of efflux pumps present at the surface of drug-resistant cells.
Cellectis

Antigen binding proteins

The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid p component (sap), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, alzheimer's disease, and type 2 diabetes..
Glaxo Group Limited

Biological pacemakers incorporating hcn2 and skm1 genes

It is demonstrated that hyperpolarization-activated cyclic nucleotide-gated (hcn)-based biological pacing, especially that achieved by transduction of the hcn2 gene into cardiac cells in vivo, was significantly improved by co-transduction of the skeletal muscle sodium channel 1 (skmi) gene. Expression of both genes hyperpolarized the action potential (ap) threshold.
The Trustees Of Columbia University In The City Of New York

Method for purifying beta-nicotinamide mononucleotide

The present invention discloses a method for purifying β-nicotinamide mononucleotide, comprising the steps of: a. Sequentially microfiltrating and nanofiltrating a pretreated β-nicotinamide mononucleotide solution with membrane concentration devices, to collect a concentrated crude product solution; b.
Bontac Bio-engineering (shenzhen) Co., Ltd

Polynucleotides, vectors and methods for insertion and expression of transgenes

Embodiments herein include polynucleotides, vectors and methods for the insertion and expression of transgenes. In an embodiment, a polynucleotide is included.
New Hope Research Foundation

Chiral nucleic acid adjuvant having antitumor effect and antitumor agent

The present invention relates to an adjuvant for anti-tumor agent, wherein the adjuvant comprises oligonucleotides which comprise two to four cpg motif each represented by 5′-x1cpgx2-3′ and has a length of 14 to 32 nucleotides, wherein a nucleic acid at 3′ end side of at least two cpg motifs is connected by phosphorothioate linkage, wherein each nucleic acid at 3′ end and 5′ end of the oligonucleotide is s type nucleic acid connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. The present invention relates to an anti-tumor agent containing its adjuvant..

Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent

An adjuvant which comprises oligonucleotides which comprise two to four cpg motifs each represented by 5′-x1cpgx2-3′ and has a length of 14 to 32 nucleotides, wherein a nucleic acid at 3′ end side of at least two cpg motifs is connected by phosphorothioate linkage, wherein each nucleic acids at 3′ end and 5′ end of the oligonucleotide is s type nucleic acids connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. The present invention relates to an adjuvant comprising the oligonucleotide represented by the sequence number 67.
Wave Life Sciences Japan, Inc

Nucleic acid vaccines

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (navs) comprising polynucleotide molecules encoding one or more antigens.. .
Moderna Therapeutics, Inc.

Substituted nucleosides, nucleotides and analogs thereof

Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof..
Alios Biopharma, Inc.

Method for inducing resistance to stress caused by pathogens in plants

Polypeptide having activity inducing pathogen plant defence, nucleotide sequence encodes it, microorganism, compositions and methods. The polypeptide is a subtilisin derived from a strain of acremonium strictum.
Consejo Nacional De Investigaciones Cientificas Y Tecnicas (conicet)

Methods and compositions for weed control using epsps polynucleotides

Provided are novel polynucleotide compositions for enhancing the herbicidal activity of glyphosate. Specifically provided are methods and compositions for modulating 5-enolpyruvylshikimate-3-phosphate synthase (epsps) in plant species.
Monsanto Technology Llc

Method of detecting coccidioides species

The present technology provides methods and kits that may be used to detect and quantify the presence of coccidioides species. The methods include quantification real-time pcr assays, and the kits and compositions include oligonucleotides used as primers and probes..
Arizona Board Of Regents On Behalf Of Northern Arizona University

Mirnas as non-invasive biomarkers for parkinson's disease

The present invention relates to methods, kits and means for diagnosing parkinson's disease in a blood sample from a subject. Further, the present invention relates to a set of polynucleotides for detecting sets of mirnas for diagnosing parkinson's disease in a blood sample from a subject..
Hummingbird Diagnostics Gmbh

Method and kit for target molecule characterization

Methods and kits for characterizing molecules, such as nucleic acids, large oligonucleotides, or portions thereof and/or to methods and kits for preparing samples for a characterization process are disclosed. Exemplary methods and kits can be used to form addressable portions, such that the addressable portions can be identified, sequenced, and reassembled to reconstruct an exemplary or characteristic molecule of a target molecule..
Fry Laboratories, L.l.c.

Hydroxymethyl linkers for labeling nucleotides

The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods.
Intelligent Biosystems, Inc.

Method for testing a mutant gene through real time polymerase chain reaction using inhibition of 5'-flap endonuclease activity

The present invention relates to a method for detecting single nucleotide polymorphism (snp) using a feature that the 5′-flap endonuclease (fen) activity of dna polymerase is inhibited when a probe complementarily binds to the end of a polymerase chain reaction (pcr) product. More specifically, the present invention relates to a novel method wherein it was verified that, when a probe used for a real-time pcr complementarily binds to the end site of a pcr product, the 5′-fen activity of thermostable dna polymerase to the probe is inhibited, and thus when such a feature is used to make a design such that an snp site to be detected is located at the 5′-end site of the probe, the 5′-flap formation is induced according to the allele, thereby allowing effective snp detection..
Genotech Corp.

Systems and methods for universal tail-based indexing strategies for amplicon sequencing

Some embodiments of the invention include a method of preparing a sample for sequencing that includes receiving a sample and amplifying at least one marker within the sample. In some embodiments, amplification of the first marker may include mixing the sample with a first oligonucleotide that comprises a first universal tail sequence and a second oligonucleotide that comprises a second universal tail sequence.
Arizona Board Of Regents On Behalf Of Northern Arizona University

Stable nad/nadh derivatives

The present invention provides for stable nicotinamide adenine dinucleotide (nad/nadh) and nicotinamide adenine dinucleotide phosphate (nadp/nadph) derivatives of formula (i), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.. .
Roche Diabetes Care, Inc.

Plants with enhanced photosynthesis and methods of manufacture thereof

A transgenic plant having enhanced photosynthesis is disclosed. The transgenic plant is transformed with a transgenic polynucleotide encoding a heterologous bicarbonate transporter.
The University Of Massachusetts

Methods and compositions employing a sulfonylurea-dependent stabilization domain

Methods and compositions are provided which employ polypeptides having a su-dependent stabilization domain, and nucleotide sequences encoding the same. Such su-dependent stabilization domains can be employed a part of a fusion protein comprising a polypeptide of interest.
Pioneer Hi-bred International, Inc.

Ap2 domain transcription factor odp2 (ovule development protein 2) and methods of use

Methods and compositions for modulating plant development are provided. nucleotide sequences and amino acid sequences encoding ovule development protein 2 (odp2) proteins are provided.
Pioneer Hi Bred International Inc

Compositions and methods for treatment of prostate and other cancers

Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp27. A therapeutic agent, for example an antisense oligonucleotide or rnai nucleotide inhibitor with sequence specificity for hsp27 mrna, for example human hsp27 mrna, is administered to an individual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount.
The University Of British Columbia

Oligonucleotide-based inhibitors comprising locked nucleic acid motif

The present invention relates to chemical modification motifs for oligonucleotides. The oligonucleotides of the present invention, such as chemically modified antisense oligonucleotides, can have increased in vivo efficacy.
Miragen Therapeutics, Inc.

Apparatus and estimating heat treatment condition, fragmenting nucleic acid, and non-transitory computer readable storage medium having computer program

Disclosed is an apparatus configured to estimate a heat treatment condition, the apparatus including: an input unit configured to receive an input of information of one to three heat treatment conditions selected from the group consisting of: heating time; heating temperature; kind of a buffer agent; and salt concentration of a sample which contains the nucleic acid and the buffer agent, and an input of information of a desired average nucleotide length; and a controller programmed to perform operations comprising: on the basis of the information the inputs of which have been received by the input unit, estimating a heat treatment condition selected from the group consisting of: the heating time; the heating temperature; the kind of the buffer agent; and the salt concentration of the sample.. .
Sysmex Corporation

Methods and compositions for creating altered and improved cells and organisms

The present invention relates to compositions involving randomized in-frame fusion polynucleotides and their introduction into a host organism to identify desirable phenotypic changes. The present invention further relates to methods of generating these randomized in-frame fusion polynucleotides by introducing randomized in-frame fusion polynucleotides into an organism, selecting for organisms with new or altered phenotypes, re-isolating the randomized in-frame fusion polynucleotides from the selected organisms, re-assembling the constituent polynucleotides of the re-isolated randomized in-frame fusion polynucleotides into new collections of randomized in-frame fusion polynucleotides, and repeating the selection for organisms with new or altered phenotypes..

Penicillin-g acylases

The present disclosure relates to engineered penicillin g acylase (pga) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.. .
Codexis, Inc.

Variants of gh family 5 endoglucanase and polynucleotides encoding same

The present invention relates to gh family 5 endoglucanase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s

Alpha-amylase variants

The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Novozymes A/s

Methods and compositions for gene inactivation

Disclosed herein are methods and compositions for inactivating ccr-5 genes, using zinc finger nucleases (zfns) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding zfns, vectors comprising polynucleotides encoding zfns, such as adenovirus (ad) vectors, and cells comprising polynucleotides encoding zfns and/or cells comprising zfns are also provided..
Sangamo Biosciences, Inc.

Antibody therapeutics that bind psma

There is disclosed compositions and methods relating to or derived from anti-psma antibodies. More specifically, there is disclosed fully human antibodies that bind psma, psma-antibody binding fragments and derivatives of such antibodies, and psma-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.

Mycobacterial antigen composition

The present invention provides an antigenic composition for use as a mycobacterial vaccine, said composition comprising (i) a first mycobacterial antigenic polypeptide, wherein said first mycobacterial antigenic polypeptide comprises a polypeptide sequence having at least 70% amino acid sequence identity to the amino acid sequence of seq id no: 6, 12, 2, 18, 8, 10, 6, 4, or a fragment thereof having at least 50 consecutive amino acids thereof; or (ii) a first mycobacterial polynucleotide, wherein said first mycobacterial polynucleotide comprises a polynucleotide sequence encoding said first mycobacterial antigenic polypeptide, or 10 wherein said first mycobacterial polynucleotide comprises a polynucleotide sequence selected from seq id no: 5, 11, 1, 17, 7, 9, 15, 3.. .
The Secretary Of State For Health

Prostate specific membrane antigen binding fibronectin type iii domains

Psma binding fn3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.. .
Janssen Biotech, Inc.

Human relaxin analogue, pharmaceutical composition of same, and pharmaceutical application of same

Disclosed are a human relaxin analogue, a polynucleotide encoding the human relaxin analogue, a pharmaceutical composition comprising the human relaxin analogue, and a pharmaceutical application of the human relaxin analogue. Also disclosed is a derivative of the human relaxin analogue..
Jiangsu Hengrui Medicine Co., Ltd.

Isolated nucleotide sequences encoding gdf traps

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.. .
Acceleron Pharma Inc.

Polynucleotide for cell surface layer expression

Disclosed is a polynucleotide for cell surface expression. The polynucleotide of the invention comprises a promoter, a secretion signal sequence, a sequence encoding an intended protein, and a sequence encoding a cell surface-localized protein or a cell membrane-binding domain thereof, wherein the promoter is a promoter of a gene encoding the cell surface-localized protein.
National University Corporation Kobe University

Radioiodinated compounds

This disclosure relates to reagents and methods useful in the synthesis of aryl iodines, for example, in the preparation of iodine labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds..
Nutech Ventures





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