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Nucleic Acids patents

This page is updated frequently with new Nucleic Acids-related patent applications. Subscribe to the Nucleic Acids RSS feed to automatically get the update: related Nucleic RSS feeds. RSS updates for this page: Nucleic Acids RSS RSS

Method and apparatus for nucleic acid analysis

Date/App# patent app List of recent Nucleic Acids-related patents
 Compositions and methods for altering alpha- and beta-tocotrienol content patent thumbnailCompositions and methods for altering alpha- and beta-tocotrienol content
Preparation and use of isolated nucleic acids useful in altering the oil phenotype in plants. Isolated nucleic acids and their encoded polypeptides that alter alpha- and beta-tocotrienol content in seeds and oil obtained from the seeds.
 Mutant luciferases patent thumbnailMutant luciferases
Described are mutant luciferases, nucleic acids that encode them, cells and animals expressing them, methods of use thereof, and kits.. .
 Cell-permeable peptide inhibitors of the jnk signal transduction pathway patent thumbnailCell-permeable peptide inhibitors of the jnk signal transduction pathway
The present invention refers to protein kinase inhibitors and more specifically to inhibitors of the protein kinase c-jun amino terminal kinase. Additionally, the present invention provides jnk inhibitor sequences, chimeric peptides, nucleic acids encoding same as well as pharmaceutical compositions for treating pathophysiologies associated with jnk signaling..
 Method and apparatus for nucleic acid analysis patent thumbnailMethod and apparatus for nucleic acid analysis
A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated rnas and micrornas, of which the types of target nucleic acids is 10000 or lower.
 Plants having enhanced abiotic stress resistance patent thumbnailPlants having enhanced abiotic stress resistance
Means are provided of increasing the growth potential and abiotic stress resistance in plants, characterized by expression of polynucleotides stably integrated into a plant genome or stably incorporated in the plant. Further provided are isolated nucleic acids and their stable inclusion in transgenic plants.
 Glucanases, nucleic acids encoding them and methods for making and using them patent thumbnailGlucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-d-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-d-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-d-glucans or xyloglucans and other plant material containing cellulosic parts.
 Method for isolating nucleic acids patent thumbnailMethod for isolating nucleic acids
The present invention pertains to a method for isolating nucleic acids from a sample, preferably a blood sample, comprising the following steps: a) obtaining a sample which has been stabilised by the use of at least one cationic detergent, wherein the cationic detergent has formed complexes with the nucleic acids; b) obtaining the complexes optionally together with other sample components from the stabilised sample, wherein said complexes comprise the nucleic acids to be isolated; c) resuspending the complexes and optionally adding one or more additives before, during and/or after resuspension, thereby obtaining a resuspended sample comprising at least: i) the nucleic acid to be isolated; ii) at least one chaotropic agent; and iii) at least one chelating agent; and d) isolating nucleic acids from the resuspended sample. It was found that adding a chelating agent during resuspension considerably increases the nucleic acid yield as the formation of precipitates which irreversibly adhere to the container wall is considerably reduced..
 Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media patent thumbnailCompositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
The present invention provides compositions and methods for improving nucleic acid or protein recovery from fixed biological samples.. .
 Methods for amplifying hepatitis c virus nucleic acids patent thumbnailMethods for amplifying hepatitis c virus nucleic acids
A method of amplifying an hcv nucleic acid in an hcv infected sample comprises amplifying a segment of a dna template that is complementary to a genome of hcv rna from the sample by a two-stage pcr, wherein a first stage pcr employs a first outer primer and a second outer primer, and a second stage pcr employs a first inner primer and a second inner primer. The nucleotide sequence of the first outer primer comprises a nucleotide sequence as set forth in seq id no: 2; or seq id no:9, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of seq id no: 9.
 Blood collection device for stabilizing cell-free rna in blood during sample shipping and storage patent thumbnailBlood collection device for stabilizing cell-free rna in blood during sample shipping and storage
A method for preserving and protecting cell-free nucleic acids located within blood plasma samples is disclosed, wherein a sample of blood containing nucleic acids is treated to reduce deleterious effects of storage and transport.. .
Cyclodextrin-based materials compositions and uses related thereto
This application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that release such active agents under controlled conditions.
Tmem22 peptides and vaccines including the same
Isolated peptides composed of the amino acid sequence of seq id no: 33 or fragments thereof that bind to hla antigens and have cytotoxic t lymphocyte (ctl) inducibility and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines are described herein. The present invention further provides peptides that include one, two, or several amino acid insertions, substitutions or additions to the aforementioned peptides or fragments, but yet retain the requisite cytotoxic t cell inducibility.
C1orf59 peptides and vaccines including the same
The present invention provides isolated peptides having the amino acid sequence of seq id no: 43 or immunologically active fragments thereof, which bind to hla antigen and have cytotoxic t lymphocyte (ctl) inducibility. The present invention further provides peptides which include one, two, or several amino acid insertions, substitution or addition to the aforementioned peptides or fragments, but still have the cytotoxic t cell inducibility.
Sp35 antibodies and uses thereof
Endogenous sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (negative regulator). Molecules that block endogenous sp35 function, such anti-sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction.
Method of purifying nucleic acids, method of extracting nucleic acids and kit for purifying nucleic acids
[solving means] a method of purifying nucleic acids including the step of adsorbing substances in a sample containing nucleic acids with an ion exchange resin 10 including a positive ion exchange resin and a negative ion exchange resin. As the positive ion exchange resin, a first positive ion exchange resin and a second positive ion exchange resin having an exclusion limit molecular weight lower than that of the first positive ion exchange resin may be used..
Organelle targeting nanocarriers
Provided are organelle targeting nanocarriers, including peptides, which act to deliver biological molecules such as nucleic acids to non-nuclear organelles such as mitochondria and chloroplasts. Also provided are methods for genetic transformation of non-nuclear organelles using such nanocarriers..
Stabilized nucleic acid dark quencher-fluorophore probes
The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support.
Methods for the synthesis of functionalized nucleic acids
Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from h-phosphonates in a stereospecific fashion..
Isolation of nucleic acids
Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool..
Isolation of nucleic acids
Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool..
Isolation of nucleic acids
Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool..
B7-related nucleic acids and polypeptides useful for immunomodulation
The present invention provides nucleic acids encoding b7-related factors that modulate the activation of immune or inflammatory response cells, such as t-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding b7-related polypeptides, including bsl1, bsl2, and bsl3.
Synthetic peptides and peptide mimetics
The present invention provides parotid secretory protein peptides, nucleic acids encoding the peptides, and methods of using the peptides, and methods of screening gl13 mimetics.. .
Modulation of microrna-138 for the treatment of bone loss
There is provided nucleic acids (mir-138 antimirs) for use in treating or preventing bone loss in a patient. Also there is provided a method for reducing the levels of endogenous mir-138 in a cell..
Method for preparing nucleic acid aptamer
An object of the present invention is to develop and provide a method for efficiently and conveniently producing a nucleic acid aptamer, particularly, a dna aptamer, having high specificity for and high binding activity against a target substance. The present invention provides a method for producing a nucleic acid aptamer, comprising: a complex formation step of mixing a single-stranded nucleic acid library with a target substance in a solution to form a complex of a single-stranded nucleic acid and the target substance; an immobilization step of mixing the solution after the preceding step with a solid-phase support to immobilize the complex onto the solid-phase support via connector(s) adsorbed on the target substance and/or the solid-phase support; a recovery step of recovering the complex immobilized on the solid-phase support from the solution; an amplification step of recovering the single-stranded nucleic acid from the complex, followed by amplification by a nucleic acid amplification method; and a single-stranded nucleic acid preparation step of converting the double-stranded nucleic acids obtained in the amplification step into single strands and then forming an intramolecular conformation..
Multiplex capture of nucleic acids
Methods of capturing two or more nucleic acids simultaneously from a single sample are provided. Different nucleic acids are captured through cooperative hybridization events on different subsets of particles or at different selected positions on a spatially addressable solid support.
Thermus brockianus nucleic acid polymerases
The invention provides nucleic acids and polypeptides for nucleic acid polymerases from a thermophilic organism, thermus brockianus. The invention also provides methods for using these nucleic acids and polypeptides..
Low sequence bias single-stranded dna ligation
The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3′-overhang region such that the overhang is able to hybridize to nucleotides present in the 3′ end of the acceptor molecule..
Methods and compositions for determining the purity of chemically synthesized nucleic acids
This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies..
Nanowire-based system for analysis of nucleic acids
System for detection and/or analysis of nucleic acids using nanowires to detect covalent modification of nucleic acids.. .
Methods and compositions for modulation of amplification efficiency
Provided herein are methods and kits for modulating the amplification efficiency of nucleic acids, which are useful in multiplex reactions where the amplification efficiency of one or more nucleic acids in the mixture are desired to be modulated relative to one or more other nucleic acids. Embodiments relate to molecular diagnostics, including detecting sequence variants, such as snps, insertions deletions, and altered methylation patterns, as well as the modulation of the amplification efficiency of internal control sequences to provide more accurate control sequences for amplification reactions..
Isolation of nucleic acids
Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool..
Single-cell nucleic acid analysis
The present invention provides methods for analysis of genomic dna and/or rna from small samples or even single cells. Methods for analyzing genomic dna can entail whole genome amplification (wga), followed by preamplification and amplification of selected target nucleic acids.
Biological specimen collection and transport system and method of use
Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay.
Novel agents for the prevention of leishmaniasis
The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of leishmania, said nucleic acids responding to one of the sequences seq id no:1, seq id no:2, seq id no:3, seq id no:4, seq id no:5 et seq id no:11 and coding for a protein respectively exhibiting a sequence seq id no:6, seq id no:7, seq id no:8, seq id no:9, seq id no:10 et seq id no:12. The invention can be used for over-expression of the genes of leishmania coding for an excretion/secretion antigen..
Stable and soluble antibodies inhibiting tnf alpha
The present invention relates to particularly stable and soluble scfv antibodies and fab fragments specific for tnf, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of tnf, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of tnf-mediated disorders.
Genetic markers for myb28
The present invention relates to a method for determining the genotype of a cruciferous vegetable plant for a plant with an increased glucosinolate level, comprising obtaining a sample of nucleic acids from said plant or a portion thereof and detecting in said nucleic acids a polymorphism at the myb28 locus that is genetically linked to an increased glucosinolate level. The polymorphism may comprises at least one of: a) a single nucleotide polymorphism (snp) at a position corresponding to nucleotide 83, 136, 226, 563, 610, 830, 995, 1116, 1513, 1577, 1606, 1620, 1825, 1863, 1877 or 2026 of seq id no: 1, or b) a polymorphism in the number of nucleotides present between nucleotides 323 and 332, between nucleotides 521 and 524, between nucleotides 783 and 786, between nucleotides and 909 and 914, between nucleotides 1365 and 1369, between 1811 and 1821, or between nucleotides 2046 and 2056 of seq id no: 1, or c) a polymorphism in the number of nucleotides present between nucleotides 836 and 837, between nucleotides 867 and 868, or between nucleotides 943 and 944 of seq id no: 1..
Optical sorting method
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention..
Antigenic compositions and use of same in the targeted delivery of nucleic acids
Methods and compositions are provided for delivery of therapeutic nucleic acids to a target cell. A chimeric antigen is provided to encapsulate, bind, or otherwise carry a nucleic acid molecule to a target cell where the chimeric antigen and nucleic acid are internalized, for example by receptor-mediated endocytosis.
Antisense oligonucleotide modulation of raf gene expression
Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides.
Novel receptor nucleic acids and polypeptides
Disclosed are nucleic acids encoding baff-r polypeptides, as well as antibodies to baff-r polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided..
Ligation enhancement
Compositions and methods are provided for enhancing enzymatic ligation between nucleic acid fragments that relies on one or more small molecule enhancers having a size of less than 1000 daltons. For example, enhancement of ligation efficiencies are observed for double-stranded nucleic acid fragments that are blunt-ended, have a single nucleotide overhang at the ligation end, or have staggered ends compared to ligation under similar conditions in the absence of the one or more small molecule ligation enhancer.
Nucleic acids encoding a human monoclonal antibody that specifically binds to il-1a
Fully human monoclonal abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for il-1α and (ii) a constant region that is effective at both activating the complement system though c1q binding and binding to several different fc receptors.. .
Methods for genomic modification
Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more integration polynucleotides comprising an exogenous nucleic acid to be integrated into a genomic target site, and a nuclease capable of causing a double-strand break near or within the genomic target site..
Nano-pcr: methods and devices for nucleic acid amplification and detection
Methods, devices, and compositions are described that provide for amplification of nucleic acid sequences without reliance upon temperature cycling, thus freeing the methods from conventional benchtop thermal cycling devices. Denaturation of double stranded nucleic acids, primer annealing, and precision control over primer extension by polymerase can be accomplished by applying stress to a nucleic acid.
Recombinant microorganism and methods of production thereof
The invention relates, inter alia, to novel genetically modified microorganisms capable of using co to produce 1-butanol and/or a precursor thereof, novel methyltransferases and nucleic acids encoding same, methods for producing genetically modified microorganisms using said novel methyltransferases, and methods of producing 1-butanol and/or a precursor thereof by microbial fermentation.. .
Dhad variants for butanol production
Dihydroxy-acid dehydratase (dhad) variants that display increased dhad activity are disclosed. Such enzymes can result in increased production of compounds from dhad requiring biosynthetic pathways.
Use of glycoside hydrolase 61 family proteins in processing of cellulose
The invention provides recombinant gh61 proteins obtained from myceliophtora thermophila, and nucleic acids that encode such proteins. The invention also provides protein fractions isolated from m.
Linear amplification of short nucleic acids
The present teachings provide novel methods for amplifying short nucleic acids. In some embodiments, the present teachings provide novel methods for linearly amplifying a collection of micro rnas by using temperature cycling during a reverse transcription reaction.
Assays for the detection of genotype, mutations, and/or aneuploidy
The present invention provides amplification-based methods for detection of genotype, mutations, and/or aneuploidy. These methods have broad applicability, but are particularly well-suited to detecting and quantifying target nucleic acids in free fetal dna present in a maternal bodily fluid sample..
Labeled nucleotide analogs
Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions that include structural components including double-stranded nucleic acids. In some embodiments, the structural components maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated..
Noninterfering multipurpose compositions for collecting, transporting and storing biological samples
The invention is directed to compositions and methods for collecting, transporting, and storing microorganisms obtained from samples of biological, clinical, forensic, and environmental origin. Compositions preserve the viability of the collected organisms, permit long-term storage, and are compatible with subsequent manipulation including propagation and culture of collected microorganisms, or isolation, purification, detection, and characterization of proteins, nucleic acids and macromolecules.
Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof
The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective cd4 and cd8 t cell responses by functionally linking listerial or other bacterial signal peptides/secretion chaperones as n-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These n-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any pest sequences native to the sequence, and/or for certain hydrophobic residues..
Novel simian t-cell lymphotropic virus
Disclosed are the simian t-cell lymphotropic virus type 3 subtype d (stlv-3 subtype d), isolated nucleic acid molecules encoding stlv-3 subtype d polypeptides, such as stlv-3 subtype d envelope, protease, polymerase, tax, rex, and capsid polypeptides, isolated polypeptides encoded by such nucleic acids. Methods are also disclosed for detecting stlv-3 subtype d, for example by detecting a stlv-3 subtype d nucleic acid or polypeptide in the sample.
Antibodies that specifically bind to serum albumin without interfering with albumin's capability to interact with the fcrn
Antibodies that specifically bind to an epitope on the serum albumin, including human and/or mouse serum albumin are provided. Nucleic acids encoding such antibodies and cells capable of expressing such antibodies are also provided..
Nucleic acids encoding antibody molecules which bind il-17a and il-17f
The invention relates to antibody molecules having specificity for antigenic determinants of both il-17a and il-17f, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.. .
Genetic products differentially expressed in tumors and the use thereof
The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins..
Coagulation factor ix compositions and methods of making and using same
The present invention relates to compositions comprising factor ix coagulation factors linked to extended recombinant polypeptide (xten), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.. .
Method for purification of nucleic acids, particularly from fixed tissue
The invention relates to a method for purification of nucleic acids, to a kit for performing the method according to the invention and to a new application of magnetic particles for purification of a biological sample. The method according to the invention comprises the following steps: a) accommodating of the sample in a first sample vessel in an aqueous solution and lysing of the sample under non-chaotropic conditions; suspending of first magnetic particles in the solution and inserting of the first sample vessel in a sample vessel holder, wherein the sample vessel is inserted in the annular interior space of a ring magnet associated with the sample vessel holder; separating of the solution from the magnetic particles; and isolating of the nucleic acids from the solution..
Plants having enhanced yield-related traits and a method for making the same
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a yield enhancing protein (yep).
High-resolution melting analysis
The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample.
Targeting lipids
Where l100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, l101 is a ligand or —ch2ch2(och2ch2)po(ch2)qch2-ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells.
Nucleic acids involved in viral infection
Provided herein are isolated viral and human nucleic acids associated with viral infection and various nucleic acid molecules relating thereto or derived therefrom. The nucleic acids may be useful for the prevention, treatment and diagnosis of viral infections..
Albumin fusion proteins
Provided herein are albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins and vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins and using these nucleic acids, vectors, and/or host cells also are provided.
Apolipoprotein e polypeptides and their use
Disclosed herein are several apoplipoprotein e (apoe) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as a hepatitis c virus infection. These apoe polypeptides can inhibit the entry of hepatitis c virus into cells, and inhibit viral replication.
Compositions and methods for selection of nucleic acids containing modified bases
Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired property.
Method and nucleic acids for the analysis of colorectal cell proliferative disorders
The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders as well as therapy thereof by analysis of the gene eya4 and its promoter and regulatory sequences. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said gene as well as methods, assays and kits thereof..
Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like.
Methods of nucleic acid quantification and detection using anomalous migration
Described are approaches for the identification, detection, and quantification of nucleic acids in a biological sample. These methods are based, in part, on the elucidation of anomalous migration properties of short nucleic acid molecules when conjugated to a fluorescent label, such as fluorescein labels, such that a smaller nucleic acid reliably migrates slower than a larger nucleic acid under the same conditions of separation..
Lyase enzymes, nucleic acids encoding them and methods for making and using them
This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
Biological materials related to cxcr7
The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting cxcr7 mediated tumour growth..
Antibody-like proteins for therapeutic and diagnostic use
Disclosed herein are recombinant protein scaffolds for use in producing antigen-binding proteins. Related antigen-binding proteins are also provided herein.
Variants of the tnf superfamily and uses thereof
Described are novel variants of april that modulate signaling via receptor-specific agonist activity, and nucleic acids encoding these variant proteins. Further described is the use of these novel proteins in the treatment of april-associated disorders, in particular, pathologies of the immune system and oncological disorders..
Method for treating psoriasis by administering an anti-il-12 antibody
Isolated anti-il-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing il-12 related conditions, diseases, and disorders, such as psoriasis.. .

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