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Nucleic Acids patents



      
           
This page is updated frequently with new Nucleic Acids-related patent applications. Subscribe to the Nucleic Acids RSS feed to automatically get the update: related Nucleic RSS feeds. RSS updates for this page: Nucleic Acids RSS RSS


Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity

Date/App# patent app List of recent Nucleic Acids-related patents
08/21/14
20140237687
 Plants having enhanced yield-related traits and a method for making the same patent thumbnailPlants having enhanced yield-related traits and a method for making the same
The present invention provides a method for enhancing various economically important yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a patl (patellin) polypeptide, a prp38 (precursor rna processing factor 38) polypeptide, an ada2 (adaptor 2) polypeptide, a gata-like polypeptide, or a wd40 repeat (wdr) 23-like polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a patl polypeptide, a prp38 polypeptide, an ada2 polypeptide, a gata-like polypeptide, or a wdr23-like polypeptide, which plants have improved yield-related traits relative to corresponding wild type plants or other control plants.
08/21/14
20140237632
 Rapidly maturing fluroscent proteins and methods for using the same patent thumbnailRapidly maturing fluroscent proteins and methods for using the same
Nucleic acid compositions encoding rapidly maturing fluorescent proteins, as well as non-aggregating versions thereof (and mutants thereof) as well as the proteins encoding the same, are provided. The proteins of interest are proteins that are fluorescent, where this feature arises from the interaction of two or more residues of the protein.
08/21/14
20140235842
 Convenient and efficient purification method for chemically labeled nucleic acids patent thumbnailConvenient and efficient purification method for chemically labeled nucleic acids
In particular, the present invention relates to a convenient method for purifying labeled nucleic acids in a fast manner with high efficiency from a mixture of unreacted hydrophobic chemical probes, unreacted nucleic acids and labeled nucleic acids, comprising the steps of reacting hydrophobic chemical probe and nucleic acids in an aqueous solution to prepare a reacted solution; adding organic solvent to the reacted solution and stirring it to obtain a mixed solution; and centrifuging the mixed solution and removing organic solvent phase.. .
08/21/14
20140235841
 Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity patent thumbnailDouble-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsrna) having specific biological activities, which includes acting as a selective agonist for activation of the toll-like receptor 3. Its “rugged” molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation).
08/21/14
20140235833
 Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same patent thumbnailMethod of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same
The present invention relates to an isolated antibody against her1, an isolated antibody against cd147, an isolated antibody against cd73, and an isolated antibody against epcam; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies.
08/21/14
20140235483
 Parallel determination of competitive binding and target specificity of a binding compound library by high-throughput dna sequencing patent thumbnailParallel determination of competitive binding and target specificity of a binding compound library by high-throughput dna sequencing
The invention is directed to a method for analyzing the competitive binding and target (or ligand) specificity of large numbers of candidate binding compounds with respect to a predetermined reference compound. That is, the invention provides a method for essentially conducting a massively parallel elisa on each member of an entire library of candidate binding compounds at the same time.
08/21/14
20140235470
 Multiplex nucleic acid detection methods patent thumbnailMultiplex nucleic acid detection methods
Methods for multiplex ligation-dependent probe amplification include (a) providing a sample tissue to query different target nucleic acids, (b) providing different probe sets for each of the target nucleic acids, each probe set including a first locus specific probe having a first adapter sequence and a first target specific portion and a second locus specific probe having a second adapter sequence, and a second target specific portion adjacent to the first target specific portion, (c) hybridizing the probe sets to the target sequences to form hybridization complexes, (d) ligating the hybridization complexes to form ligated probes, (e) amplifying the ligated probes to form amplicons, the amplifying step being carried out with a first universal primer including a region complementary to the first adapter sequence and a second universal primer including a region complementary to the second adapter sequence, and (f) detecting the amplicons in a detection system by sequencing each of the amplicons.. .
08/21/14
20140235464
 Detection and quantification of biomolecules using mass spectrometry patent thumbnailDetection and quantification of biomolecules using mass spectrometry
The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry.
08/21/14
20140234943
 Viruses lacking epithelial cell receptor entry patent thumbnailViruses lacking epithelial cell receptor entry
The document provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The document also provides methods for using viruses to treat cancer patients.
08/21/14
20140234933
 Egvii endoglucanase and nucleic acids encoding the same patent thumbnailEgvii endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding egvii amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvii, recombinant egvii proteins and methods for producing the same..
08/21/14
20140234932
Bgl7 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding bgl7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl7, recombinant bgl7 proteins and methods for producing the same..
08/21/14
20140234931
Bgl6 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding bgl6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl6, recombinant bgl6 proteins and methods for producing the same..
08/21/14
20140234926
Recombinant anaerobic acetogenic bacteria for production of isoprene and/or industrial bio-products using synthesis gas
This invention provides for recombinant anaerobic acetogenic bacterial cells having one or more nucleic acids whereby isoprene, mevalonate and/or other industrial bio-products are produced in a substantially oxygen-free culture condition using synthesis gas as energy and/or carbon source.. .
08/21/14
20140234924
Variants of glycerol dehydrogenase having d-lactate dehydrogenase activity and uses thereof
The present invention provides methods of designing and generating glycerol dehydrogenase (glydh) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding glydh polypeptide variants having altered function as compared to the parent polypeptide.
08/21/14
20140234909
Dna polymerases with increased 3'-mismatch discrimination
Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
08/21/14
20140234893
Heterologous intron within an immunoglobulin domain
The invention concerns the field of recombinant gene engineering. It concerns novel introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes with heterologous introns, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel intron sequences as heterologous introns..
08/21/14
20140234851
Modular extracellular sensor architecture for cell-based biosensors
The present invention provides modular extracellular sensors, nucleic acids encoding such sensors, and cells expressing such sensors, and methods of employing such sensors and cells for detecting extracellular ligands. In certain embodiments, the extracellular sensors comprise a ligand binding domain, a transmembrane domain, a protease domain, a protease cleavage site, and a transcription factor.
08/21/14
20140234848
Cryptographic methods using nucleic acid codes
Novel methods and systems for encoding cryptographic information are disclosed. A message can be encoded through a sequence of nucleic acids by assigning a binary value to a pair of nucleic acids, while other nucleic acids can be used for spacing.
08/21/14
20140234841
Compositions, methods and kits to detect dicer gene mutations
In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a dicer1 polypeptide.. .
08/21/14
20140234838
Square wave thermal cycling
Embodiments disclosed herein relate to methods and systems for analysis of melting temperatures, and particularly to analysis of duplex nucleic acids.. .
08/21/14
20140234834
Method for quantifying human dna
The invention provides for a method for quantifying one or more nucleic acids of a genome in a sample comprising the steps of (a) amplifying a first nucleic acid to be quantified, (b) determining the amount of said first nucleic acid by comparison of the amount of amplification product from said first nucleic acid with at least one amplification product from a second template nucleic acid, (c) wherein said second template nucleic acid was generated using whole genome amplification and wherein the starting concentration of the second template nucleic acid is known.. .
08/21/14
20140234832
Methods and compositions for inhibiting undesired cleaving of labels
The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods.
08/21/14
20140234830
Direct amplification and detection of viral and bacterial pathogens
Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction..
08/21/14
20140234363
Polypeptides from non-typeable haemophilus influenzae
Polypeptides comprising non-typeable haemophilus influenzae (nthi) amino acid sequences. Over 2500 specific nthi proteins are disclosed.
08/21/14
20140234332
Novel hiv-2 isolate
The invention provides a novel strain of hiv-2 capable of causing immunodeficiency. The invention also provides compositions comprising the nucleic acids and polypeptides characteristic of this hiv-2 virus, antibodies specific for this hiv-2 virus, methods of using these compositions, and methods of detecting hiv-2 virus..
08/21/14
20140234265
Compositions and method for manipulating pim-1 activity in circulatory system cells
The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding the serine/threonine kinase pim-1, and methods for making and using them; including methods for inducing cellular proliferation, and protecting cardiac cells from hypoxia and cellular apoptosis. The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding pim-1, and methods for enhancing the regenerative potential of stem cells in the heart..
08/21/14
20140234221
Antigen-binding proteins comprising recombinant protein scaffolds
Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins in addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided vectors and cells useful for expression of the described proteins are also provided, as are methods of use.. .
08/21/14
20140231710
Method of making a formulation for deactivating nucleic acids
The disclosure relates to formulations for use in deactivating nucleic acids and methods of making and using the same.. .
08/21/14
20140231255
Electroblotting device
An electroblotting system including a cassette configured to receive a membrane and a material impregnated with at least one of proteins or nucleic acids. The cassette is connectable to a base such that a current is passable through the cassette to cause at least some of the proteins or nucleic acids to be transferred from the impregnated material to the membrane.
08/14/14
20140230101
Enzymes that synthesize zingiberene
The invention relates to nucleic acids encoding a zingiberene synthase that enables host cells and plants to make zingiberene that is useful in fragrances and for repelling or killing insects. The invention also relates to isolated zingiberene synthases and to methods for making zingiberenes..
08/14/14
20140230094
Yield increase in plants overexpressing the shsrp genes
A transgenic crop plant transformed by a serine hydroxymethyltransferase-like stress-related polypeptide (shsrp) coding nucleic acid, wherein expression of the nucleic acid sequence in the crop plant results in the plant's increased root growth, and/or increased yield, and/or increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic crop plants.
08/14/14
20140230087
Regulatory nucleic acid molecules for enhancing constitutive gene expression in plants
The present invention is in the field of plant molecular biology and provides methods for production of high expressing constitutive promoters and the production of plants with enhanced constitutive expression of nucleic acids wherein nucleic acid expression enhancing nucleic acids (neenas) are functionally linked to said promoters and/or introduced into plants.. .
08/14/14
20140228546
Serum albumin binding proteins
The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.. .
08/14/14
20140228247
Sequence-specific analysis of nucleic acids
The invention relates to a method for the sequence-specific analysis of nucleic acids in a sample in which the nucleic acid is present at least partially as a double strand, which method uses electrochemical detection methods (e.g. With [oso4(bipy)]).
08/14/14
20140228233
Circulating biomarkers for cancer
Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and to determine treatment efficacy. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes.
08/14/14
20140227756
Egvi endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding egvi amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvi, recombinant egvi proteins and methods for producing the same..
08/14/14
20140227743
Dna polymerases with increased 3'-mismatch discrimination
Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
08/14/14
20140227724
Nucleic acid construct for use in screening for peptide antibody, and screening method using same
The present invention provides a novel tool for simply screening a candidate molecule for an antibody and a method for screening a candidate molecule for an antibody using the tool. A nucleic acid construct includes: (x) an encoding nucleic acid of an antibody candidate, obtained by inserting an encoding nucleic acid of any peptide into an encoding nucleic acid of an antibody; (y) an encoding nucleic acid of a peptide tag; and (z) an encoding nucleic acid of an aptamer that is bindable to the peptide tag are used.
08/14/14
20140227712
Rapid method for isolating extracellular nucleic acids
The present invention pertains to a method for isolating extracellular nucleic acids from a sample, wherein said sample is optionally stabilized, by binding the extracellular nucleic acids to a solid phase which carries anion exchange groups, comprising the following steps: binding the extracellular nucleic acids to the solid phase in a binding mixture having a first ph which allows binding the extracellular nucleic acids to the anion exchange groups of the solid phase; wherein the sample makes up at least 85% of the volume of the binding mixture; separating the solid phase with the bound extracellular nucleic acids; optionally washing the extracellular nucleic acids; optionally eluting extracellular nucleic acids from the solid phase. The method has the advantage that large sample volumes can be processed and that extracellular nucleic acids can be isolated rapidly with a high yield.
08/14/14
20140227709
Methods of detecting low copy nucleic acids
Methods are provided for detecting low copy nucleic acids of interest in a sample. In one method, a sample comprising a nucleic acid of interest is aliquotted into a plurality of reaction mixtures, at least two of which are single-copy reaction mixtures.
08/14/14
20140227700
Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients..
08/14/14
20140227691
Nucleic acid isolation methods
The present invention provides methods for selectively enriching a biological sample for short nucleic acids, such as fetal dna in a maternal sample or apoptic dna in a biological sample from a cancer patient and for subsequently analyzing the short nucleic acids for genotype, mutation, and/or aneuploidy.. .
08/14/14
20140227689
Novel methods for quantification of micrornas and small interfering rnas
The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature micrornas and small interfering rnas (sirnas). The invention furthermore relates to methods for monitoring the expression of other non-coding rnas, mrna splice variants, as well as detecting and quantifying rna editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer.
08/14/14
20140227688
Stabilisation and isolation of extracellular nucleic acids
The present invention provides methods, compositions and devices for stabilizing the extracellular nucleic acid population in a cell-containing biological sample using an apoptosis inhibitor, preferably a caspase inhibitor, a hypertonic agent and/or a compound according to formula (1) as defined in the claims.. .
08/14/14
20140227687
Stabilisation and isolation of extracellular nucleic acids
The present invention provides methods, compositions and devices for stabilizing the extracellular nucleic acid population in a cell-containing biological sample using an apoptosis inhibitor, preferably a caspase inhibitor, a hypertonic agent and/or a compound according to formula (1) as defined in the claims.. .
08/14/14
20140227680
Compositions, methods and kits to detect adenovirus nucleic acids
The disclosed invention is related to methods, compositions, kits and isolated nucleic acid sequences for targeting adenovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers.
08/14/14
20140227322
Rabies virus like particle production in plants
A method of producing a virus like particle (vlp) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant.
08/14/14
20140227270
Bispecific anti-cxcr7 immunoglobulin single variable domains
The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting cxcr7 mediated tumour growth..
08/14/14
20140227266
Nogo receptor antagonists
Disclosed are immunogenic nogo receptor-1 polypeptides, nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are nogo receptor antagonist polynucleotides.
08/14/14
20140227257
Monoclonal antibodies that neutralize anthrax protective antigen (pa) toxin
The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (pa) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax pa toxin-binding ability, fully human or humanized antibodies retaining anthrax pa toxin-binding ability, and pharmaceutical compositions including such antibodies.
08/14/14
20140227181
Method of labelling a biologically active molecule with 5-fluoro-5-deoxypentose or a 3-fluoro-3-deoxypentose
The invention provides a conjugate of a biologically active molecule and a 5-fluoro-5-deoxypentose or a 3-fluoro-3-deoxypentose, wherein the biologically active molecule is selected from the group consisting of proteins, peptides, nucleic acids, oligosaccharides and polysaccharides.. .
08/14/14
20140227146
System and method for processing biological samples
A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.. .
08/07/14
20140223609
Protein mixtures for maize insect control
Embodiments of the present invention relate to insecticidal bacillus thuringiensis cry1 and cry2 polypeptides. Methods for using the polypeptides and nucleic acids of embodiments of the invention to synergistically enhance resistance of plants to insect predation are encompassed in embodiments of the present invention..
08/07/14
20140223602
Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides.
08/07/14
20140221638
Matrix and method for purifying and/or isolating nucleic acids
The present invention relates to matrix materials suitable for use in purifying and/or isolating nucleic acids from a biological sample, which matrix comprises a surface comprising at least one element selected from the group consisting of germanium, tin and/or lead, or at least one salt thereof, and methods related therewith.. .
08/07/14
20140221623
Interleukin-6 receptor binding polypeptides
The invention relates to amino acid sequences that are directed against and/or that can specifically bind to il-6 receptor, compounds or constructs that comprise said amino acid sequence, nucleic acids that encode said amino acid sequences, compounds or constructs, pharmaceutical compositions comprising said amino acid sequences, compounds or constructs as well as methods for the prevention and/or treatment of diseases and disorders associated with il-6 receptor.. .
08/07/14
20140221255
Method for large-scale synthesis of long-chain nucleic acid molecule
Systems and methods for synthesizing long-chain nucleic acids molecules are disclosed. The systems and methods described in this application use a ligation- purification-amplification (“lpa”) technique.
08/07/14
20140221241
Mass dots: nanoparticle isotope tags
Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. In multiplexed bioassays with icp-ms detection..
08/07/14
20140220658
Recombinant butyrylcholinesterases and truncates thereof
Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (bche) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated bche molecules having selected properties, especially selective formation of monomers, are also described.
08/07/14
20140220656
Constructs and methods for the production and secretion of polypeptides
Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably clostridium bacteria.
08/07/14
20140220639
Dna polymerases with increased 3'-mismatch discrimination
Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
08/07/14
20140220586
Filtering small nucleic acids using permeabilized cells
Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic dna accessibility are described.. .
08/07/14
20140220585
Biologic sample collection devices and methods of production and use thereof
Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (pcl). Methods of production and use thereof are also described herein.
08/07/14
20140220583
Nucleic acid-labeled tags associated with odorant
A nucleic acid tag comprising a nucleotide-support platform attached to a nucleic acid molecule, an odorant, and an encapsulant. Unique nucleic acid-containing tags containing an odorant are seeded at one or more geographic locations.
08/07/14
20140220582
Location analysis using fire retardant-protected nucleic acid-labeled tags
A nucleic acid tag comprising a nucleotide-support platform attached to a nucleic acid molecule, a fire retardant, and an encapsulant. Unique nucleic acid-containing tags containing a fire- or heat-protective element are seeded at one or more geographic locations.
08/07/14
20140220580
Biomarker compositions and methods
Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and to determine treatment efficacy. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes.
08/07/14
20140220573
Embodiments of a probe and method for targeting nucleic acids
Disclosed embodiments concern a probe comprising one or more pairs of monomers capable of targeting a nucleic acid target. The pair of monomers may be arranged in a manner that promotes thermoinstability of the probe complex, thus producing a probe capable of locating and/or detecting a target.
08/07/14
20140219983
Suppression of cancers
The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell.
08/07/14
20140219979
Hsp60, hsp60 peptides and t cell vaccines for immunomodulation
The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (hsp60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for hsp60 and p277 in the treatment or prevention of hepatic disorders.
08/07/14
20140219978
Gp100-specific t cell receptors and related materials and methods of use
The invention provides human cells, particularly human t cells, comprising a murine t cell receptor (tcr) having antigen specificity for the cancer antigen gp100. Isolated or purified tcrs having antigenic specificity for amino acids 154-162 of gp100 (seq id no: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided.
07/31/14
20140213637
Agents for improved delivery of nucleic acids to eukaryotic cells
New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes..
07/31/14
20140213529
Pseudomonas exotoxin a with less immunogenic b cell epitopes
The invention provides a pseudomonas exotoxin a (pe) comprising an amino acid sequence having a substitution of one or more of amino acid residues e420, d463, y481, l516, r563, d581, d589, and k606, wherein the amino acid residues are defined by reference to seq id no: 1. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions.
07/31/14
20140213527
Small humanin-like peptides
Novel peptides referred to as small humanin-like peptides (shlps) are provided herein along with nucleic acids encoding shlps and probes that selectively bind shlps. Shlps have wide-ranging activity, including neuroprotective activity, anticancer activity, and cell survival activity.
07/31/14
20140213484
Polymer co-location in surface-attached biopolymers and arrays of biopolymers
Embodiments of the present invention provide substrates having controllably co-located polymers of different sequences. Methods are provided that allow the fabrication of arrays of polymers on a substrate having controllably co-located polymers in regions of the array.
07/31/14
20140213461
Efficient base determination in sequencing reactions
The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs.


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This listing is a sample listing of patent applications related to Nucleic Acids for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nucleic Acids with additional patents listed. Browse our RSS directory or Search for other possible listings.
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