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Nucleic Acid

Nucleic Acid-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Devices, systems, and methods for high-resolution melt analysis
Canon U.s. Life Sciences, Inc.
November 09, 2017 - N°20170323051

Devices, systems, and methods for automatic genotyping obtain high-resolution melt data from a test sample defining a melting curve for a target nucleic acid in the test sample; obtain high-resolution melt data from a control sample defining a melting curve for a wild type of the target nucleic acid in the control sample; calculate melting curve derivatives of the melting ...
High affinity vitamin d3 binding proteins
University Of Washington
November 09, 2017 - N°20170322229

The present disclosure provides isolated polypeptides with vitamin d3 binding activity and methods for their use as detection agents. In another aspect, the invention provides recombinant expression vector comprising an isolated nucleic acid of the invention operably linked to a control sequence. In another aspect, the invention provides recombinant host cells comprising the recombinant expression vector of the invention. In ...
Integrated compound discovery systems and methods
Nanomedica Llc
November 09, 2017 - N°20170322206

Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with a target molecule or substance (e. G., for use in new compound or drug discovery) are described. In some embodiments the device comprises: (a) a spatially addressable array, ...
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Dna impurities in a composition comprising a parvoviral virion
Uniqure Ip B.v.
November 09, 2017 - N°20170321290

The current invention relates to nucleic acid impurities in a composition comprising a parvoviral vector. In particular, the current invention shows that dna impurities are not randomly encapsulated within a parvoviral virion. The invention therefore relates to a method for identifying and quantifying a nucleic acid impurity in a composition comprising a parvoviral vector. Finally, the current invention relates to ...
Non-replicative transduction particles and transduction particle-based reporter systems
Geneweave Biosciences, Inc.
November 09, 2017 - N°20170321289

Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods ...
Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
Momentum Bioscience, Ltd.
November 09, 2017 - N°20170321287

An assay kit of reagents including a nucleic acid capable of acting as substrate for polymerase microorganism activity useful in a method of detecting polymerase activity as an indicator of the presence of a micro-organism in a sample are disclosed. The disclosed embodiments also relate to reagents for use in such methods, and to test kits comprising such reagents for ...
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Non-invasive detection of fetal genetic traits
Sequenom, Inc.
November 09, 2017 - N°20170321279

Blood plasma of pregnant women contains fetal and (generally >90%) maternal circulatory extracellular dna. Most of said fetal dna contains ≦500 base pairs, said maternal dna having a greater size. Separation of circulatory extracellular dna of <500 base pairs results in separation of fetal from maternal dna. A fraction of a blood plasma or serum sample of a ...
Methods and compositions for nucleic acid amplification
Gen-probe Incorporated
November 09, 2017 - N°20170321273

Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (tsu) promoter primer or promoter provider oligonucleotide that includes a target specific (ts) sequence that hybridizes specifically to a target sequence that is amplified and a universal (u) sequence that is introduced into the sequence that is amplified, by using a primer ...
Combinatorial barcode sequences, and related systems and methods
Life Technologies Corporation
November 09, 2017 - N°20170321271

A kit for use with a nucleic acid sequencing instrument can include a plurality of combinatorial barcodes sequences meeting the following criteria: each of the combinatorial barcode sequences comprise a plurality of iterations of a sequence motif, where the sequence motif comprises a first nucleotide base from a first group of nucleotide bases followed by a second nucleotide base from ...
Method of determining the nucleotide sequence of oligonucleotides and dna molecules
Life Technologies Corporation
November 09, 2017 - N°20170321269

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of dna polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a dna fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base ...
Modified nucleotide reagents
Pacific Biosciences Of California, Inc.
November 09, 2017 - N°20170321268

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
Adaptors for nucleic acid constructs in transmembrane sequencing
Oxford Nanopore Technologies Ltd.
November 09, 2017 - N°20170321266

The invention relates to adaptors for sequencing nucleic acids. The adaptors may be used to generate single stranded constructs of nucleic acid for sequencing purposes. Such constructs may contain both strands from a double stranded deoxyribonucleic acid (dna) or ribonucleic acid (rna) template. The invention also relates to the constructs generated using the adaptors, methods of making the adaptors and ...
Porous matrix comprising nucleic acid primer-carbon material composites and pcr using the same
Korea Institute Of Science And Technology
November 09, 2017 - N°20170321265

A porous matrix according to the present disclosure, wherein a nucleic acid primer-carbon material composite in which one or more nucleic acid primer of a forward primer and a reverse primer as a polymerase chain reaction (pcr) primer is bound to a carbon material is included in the pores of the matrix, provides improved amplification efficiency as compared to a ...
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Probes for improved melt discrimination and multiplexing in nucleic acid assays
Luminex Corporation
November 09, 2017 - N°20170321259

Methods and compositions for the detection and quantification of nucleic acids are provided. In certain embodiments, methods involve the use of cleavable probes that comprise a ribonucleotide position that is susceptible to endoribonuclease (e. G., rnase h) cleavage in the presence of target nucleic acid molecules. Probes of the embodiments may also comprise non-natural nucleotide linked to a reporter and/...
Detection of drug resistant mycobac tuberculosis
Rutgers, The State University Of New Jersey
November 09, 2017 - N°20170321258

This invention relates to nucleic acids, reagents and methods for detecting rifampicin-resistant mycobacterium tuberculosis in a sample from a subject. In one aspect, the invention provides methods of detecting rifampicin resistant m. Tuberculosis in a sample comprising (a) amplifying a nucleic acid containing the rifampicin resistance determining region (rrdr) of the rpob gene in a sample to provide an amplified ...
Target sequence enrichment
Abbott Molecular Inc.
November 09, 2017 - N°20170321253

The present invention provides methods, systems, kits, and compositions for magnetically purifying target nucleic acid sequences from a sample using bait molecules configured to bind both target nucleic acid sequences and magnetic binding particles. In certain embodiments, the bait molecules comprise a short target capture sequence (e. G., 18 to 48 bases), and the methods employ a short hybridization time (e. G., 1...
Methods and products for quantifying rna transcript variants
Lexogen Gmbh
November 09, 2017 - N°20170321248

The present invention relates to the field of transcriptomics and provides a method for the controlled identification and/or quantification of transcript variants in samples, comprising providing a reference set of artificial polynucleic acid molecules simulating transcript variants and adding said reference set as external control to samples comprising transcript variants. The present invention further provides such a reference set, ...
Flash and glow 1,2-dioxetanes
Life Technologies Corporation
November 09, 2017 - N°20170321245

Compounds having chemiluminescent flash and glow properties. Also disclosed are methods using the compounds to generate light, detect and/or quantify enzymes, antigens, and/or nucleic acids. Also disclosed are kits relating to these compounds.
Transformed cells that ferment pentose sugars and methods of their use
Dsm Ip Assets B.v.
November 09, 2017 - N°20170321242

The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the host cell the ability to convert xylose to xylulose which may be further metabolized by the host cell. Thus, the host cell is capable of growth ...
21-hydroxylation of steroids
Sanofi
November 09, 2017 - N°20170321241

Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for ...
Diterpene synthases and method for producing diterpenoids
The University Of British Columbia
November 09, 2017 - N°20170321230

Provided herein are diterpene synthases (ditps) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding ditps, ditps amino acid sequences, ditps proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof.
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