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Nucleic Acid patents



      
           
This page is updated frequently with new Nucleic Acid-related patent applications. Subscribe to the Nucleic Acid RSS feed to automatically get the update: related Nucleic RSS feeds. RSS updates for this page: Nucleic Acid RSS RSS


Date/App# patent app List of recent Nucleic Acid-related patents
08/28/14
20140245498
 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/28/14
20140245491
 Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use patent thumbnailnew patent Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
08/28/14
20140245474
 Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold patent thumbnailnew patent Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold
Methods and materials for modulating cold tolerance levels in plants are disclosed. For example, nucleic acids encoding cold tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells.
08/28/14
20140245468
 Non-human animals with modified immunoglobulin heavy chain sequences patent thumbnailnew patent Non-human animals with modified immunoglobulin heavy chain sequences
Non-human animals, e.g., mammals, e.g., mice or rats, are provided comprising an immunoglobulin heavy chain locus that comprises a rearranged human immunoglobulin heavy chain variable region nucleotide sequence. The rearranged human immunoglobulin heavy chain variable region nucleotide sequence may be operably linked to a heavy or light chain constant region nucleic acid sequence.
08/28/14
20140245465
 Transgenic bird expressing foreign gene using endoplasmic reticulum chaperone promoter patent thumbnailnew patent Transgenic bird expressing foreign gene using endoplasmic reticulum chaperone promoter
An aim is to produce a suitable foreign protein in egg white in transgenic birds at levels equivalent to or higher than the expression levels achieved using an ovalbumin promoter or an actin promoter, and to reduce the great burden on birds by reducing the expression at sites other than the oviduct while achieving expression sufficient to predict the expression levels before the birds reach sexual maturity. Provided is a transgenic bird containing a nucleic acid base sequence in chromosome in a cell that forms the oviduct, the sequence containing: (a) an avian endoplasmic reticulum chaperone promoter; and (b) a nucleic acid base sequence encoding a suitable foreign protein, functionally linked to the promoter.
08/28/14
20140243503
 Fgf21 mutants and uses thereof patent thumbnailnew patent Fgf21 mutants and uses thereof
The invention provides nucleic acid molecules encoding fgf21 mutant polypeptides, fgf21 mutant polypeptides, pharmaceutical compositions comprising fgf21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.. .
08/28/14
20140243399
 Engineered nucleic acids and methods of use thereof patent thumbnailnew patent Engineered nucleic acids and methods of use thereof
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger rnas, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing..
08/28/14
20140243397
 Cxcr4 inhibiting carriers for nucleic acid delivery patent thumbnailnew patent Cxcr4 inhibiting carriers for nucleic acid delivery
The present invention generally relates to carriers including polymers and lipids that comprise a cxcr4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a cxcr4 inhibiting moiety.
08/28/14
20140243394
 Compositions and methods for inhibiting expression of a gene from the ebola virus patent thumbnailnew patent Compositions and methods for inhibiting expression of a gene from the ebola virus
The invention relates to a double-stranded ribonucleic acid (dsrna) for inhibiting the expression of a gene from the ebola virus.. .
08/28/14
20140243391
 Phospholipid-detergent conjugates and uses thereof patent thumbnailnew patent Phospholipid-detergent conjugates and uses thereof
The invention relates to novel compounds, in particular novel o-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy..
08/28/14
20140243242
new patent Compositions and methods for co-amplifying subsequences of a nucleic acid fragment sequence
The present invention is related to genomic nucleotide sequencing. In particular, the invention describes a single reaction method to co-amplify multiple subsequences of a nucleic acid fragment sequence (i.e., for example, at least two read pairs from a single library insert sequence).
08/28/14
20140243238
new patent Methods of co-detecting mrna and small non-coding rna
Disclosed herein are methods of co-detecting presence of target messenger rna (mrna) and small non-coding rna (for example, mirna) in a sample. The disclosed methods can be used to simultaneously detect mrna and small non-coding rna in a single assay (for example in the same reaction or the same well of a multi-well assay).
08/28/14
20140243235
new patent Peripheral neuropathy diagnosis
Genes whose expression is correlated with the presence of cidp or vasculitic neuropathy are disclosed. Probes and sets of nucleic acids and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject..
08/28/14
20140243234
new patent Nucleic acid compositions, methods and kits for rapid pairing of affinity agents
The present inventions relate to the selection and production of specific proteins or peptides with desired properties. The inventions relate to the agents and methods of identifying select peptides or proteins with specific binding properties or greater enzymatic performance from vast numbers of variants..
08/28/14
20140243232
new patent Nucleic acid complexity reduction
In some embodiments, the present teachings provide compositions, systems, methods and kits for reducing the complexity of nucleotide sequences in a nucleic acid sample comprising the steps: hybridizing a plurality of polynucleotide constructs to at least one blocker oligonucleotide and to at least one capture oligonucleotide, wherein the plurality of polynucleotide constructs include a plurality of polynucleotides each joined to at least one nucleic acid adaptor, wherein the at least one nucleic acid adaptor can hybridize to the at least one blocker oligonucleotide, and wherein the at least one capture oligonucleotide can hybridize to at least a portion of target polynucleotides that are a sub-population of the plurality of polynucleotides, so as to produce a capture duplex.. .
08/28/14
20140243230
new patent Gene expression signature for classification of kidney tumors
The present invention provides a method for classification of kidney tumors through the analysis of the expression patterns of specific micrornas and nucleic acid molecules relating thereto. Classification according to a microrna expression framework allows optimization of treatment, and determination of specific therapy..
08/28/14
20140243224
new patent Gel patterned surfaces
Provided is an array including a solid support having a surface, the surface having a plurality of wells, the wells containing a gel material, the wells being separated from each other by interstitial regions on the surface, the interstitial regions segregating the gel material in each of the wells from the gel material in other wells of the plurality; and a library of target nucleic acids in the gel material, wherein the gel material in each of the wells comprises a single species of the target nucleic acids of the library. Methods for making and using the array are also provided..
08/28/14
20140243222
new patent Multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing of corneal dystrophy and preparation method thereof producing same
A multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing corneal dystrophy, and more particularly to a multi-spot metal-capped nanostructure array nucleic acid chip capable of employing lspr (localized surface plasmon resonance) optical properties, a preparation method thereof, and a multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing bigh3 gene mutations, which can diagnose various corneal dystrophies. The metal-capped nanostructure array nucleic acid chip can be combined with analysis devices, including a light source, a detector, a spectrophotometer and a computer, to provide an lspr optical property-based optical biosensor, and the use of the multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing bigh3 gene mutations allows the simultaneous diagnosis of various corneal dystrophies that are genetic ocular diseases..
08/28/14
20140243216
new patent Methods for separating nucleic acids by size
The present invention pertains to a method for isolating nucleic acids by size from a sample comprising nucleic acids of different sizes using an anion exchange matrix, wherein nucleic acids of a preselected size or a preselected size range are isolated by varying the ph value during elution and/or binding.. .
08/28/14
20140243213
new patent Analysing sequencing bias
The present invention relates to methods for determining the sequence bias of a sequencing technique. Furthermore, the invention relates to methods to reduce or enhance sequence bias during sequencing of nucleic acids via techniques involving adaptor ligations.
08/28/14
20140242704
new patent Pef-ts expression units
The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.. .
08/28/14
20140242701
new patent Chimeric antigen receptor
Provided are a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, the chimeric antigen receptor being characterized in that an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (gitr) is contained as the intracellular domain; a nucleic acid encoding the chimeric antigen receptor; a cell expressing the chimeric antigen receptor; and a method for producing the cell.. .
08/28/14
20140242683
new patent Apparatus for selective excitation of microparticles
Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an interference pattern generation module that splits a first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams..
08/28/14
20140242674
new patent Pentose fermentation by a recombinant microorganism
The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.. .
08/28/14
20140242658
new patent Method for production of isoprenoid compounds
The present invention is directed to variant squalene synthase enzymes, including saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds, while still producing sufficient squalene to allow the s.
08/28/14
20140242649
new patent Hybrid organic-inorganic system for producing biofuels
The present invention provides for a system for converting co2 and h2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more nucleic acids encoding genes for a recombinant surface display protein which is capable of tethering an electrocatalyst molecule, such as a cobalt(ii) complex supported by tetradentate polypyridyl ligand 2-bis(2-pyridyl)(methoxy)methyl-6-pyridylpyridine (py4), and enzymes for synthesizing a biologically derived compound, such as an alkane, alcohol, fatty acid, ester, or isoprenoid..
08/28/14
20140242642
new patent Dual cofactor specific ribitol dehydrogenase and use thereof
There are provided a novel ribitol dehydrogenase, a residue determining double coenzyme specificity, and a method for preparing l-ribulose using the same, and more particularly, to a ribitol dehydrogenase producing rare sugars, nucleic acid molecules encoding the same, a vector including the nucleic acid molecules, a transformant including the vector, a mutant of the ribitol dehydrogenase, and a method for preparing l-ribulose using the ribitol dehydrogenase. The ribitol dehydrogenase having double coenzyme specificity, which is derived from zymomonas mobilis, can effectively be used for preparing high-priced rare sugars and an investigation of coenzyme specificity determinants for the ribitol dehydrogenase is applied for all of dedydrogenases as a based technique..
08/28/14
20140242637
new patent Artificial introns
The invention concerns the field of recombinant gene engineering. It concerns novel artificial introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel artificial intron sequences..
08/28/14
20140242636
new patent Regulatable promoter
A method of producing a protein of interest (poi) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a poi under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the poi at a transcription rate of at least 15% as compared to the native pgap promoter, and c) producing and recovering the poi; and further an isolated regulatable promoter and a respective expression system.. .
08/28/14
20140242594
new patent Methods and compositions for preparation of nucleic acids
A method for isolating genomic dna (gdna) from a biological material. In some embodiments, the method includes (a) contacting a sample that contains gdna with a solution of hydroxide and a detergent under conditions and for a time sufficient to degrade a cell wall, a cell membrane, a nuclear membrane, a nucleoprotein, or combinations thereof and/or to denature the gdna; (b) mixing into the solution resulting from step (a) a solution characterized by high salt and sufficient buffering capacity to reduce the ph of the solution to less than 10, thereby producing a neutralized solution; (c) centrifuging the sample at a speed and length of time sufficient to clarify the preparation; and (d) removing insoluble material from the neutralized and clarified preparation, whereby a solution of gdna is produced.
08/28/14
20140242586
new patent Chimeric primers with hairpin conformations and methods of using same
Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5′ of the target-specific primer sequence; a tag sequence 5′ of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed.
08/28/14
20140242577
new patent C-probe libraries for dna target enrichment
Provided herein is a method for enriching a target nucleic acid molecule. In one embodiment, the method may involve hybridizing a c-probe to a strand of a target nucleic acid to produce a complex, enzymatically removing any 3′ overhanging end from the target nucleic acid of the complex to produce a 3′ hydroxyl group at the 3′ end; extending the 3′ end of the first sequence using the oligonucleotide sequence of the c-probe as a template; enzymatically removing any 5′ overhanging end from the target nucleic acid, either before or after the extending step, to produce an 5′ phosphate group at the end of the second sequence; and ligating the 5′ phosphate group at the end of the second sequence to the 3′ hydroxyl group at the end of the first sequence to produce a circular dna molecule that contains the target sequence and the complement of the oligonucleotide sequence..
08/28/14
20140242155
new patent Compounds, compositions, methods, and kits relating to telomere extension
Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment.
08/28/14
20140242154
new patent Compounds, compositions, methods, and kits relating to telomere extension
Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment.
08/28/14
20140242106
new patent Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics..
08/28/14
20140242077
new patent Methods and compositions for modulating an immune response
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as t-cells (e.g., cytotoxic t-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic t-cells) in a subject (e.g., a human subject).
08/28/14
20140241996
new patent Therapeutic nanoparticles and methods of use thereof
Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-rna identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell (e.g., mir-10b) or a sequence within an mrna encoding a pro-apoptotic protein that is covalently linked to the nanoparticle. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles.
08/28/14
20140241983
new patent Methods and compositions for enhancing the therapeutic effect of anti-tumor t cells
Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of forkhead box protein 1 (foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of forkhead box protein 1 (foxp1) expression, viral vectors containing such molecules, t cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate foxp1.
08/28/14
20140239223
new patent Method of making a formulation for deactivating nucleic acids
The disclosure relates to formulations for use in deactivating nucleic acids and methods of making and using the same.. .
08/28/14
20140238860
new patent Nucleic acid sample preparation
The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples..
08/28/14
20140238859
new patent Nucleic acid sequencing by electrochemical detection
Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in ph to monitor base addition. In some embodiments the electrochemical hydrogen ion sensor is a microfabricated mixed metal oxide electrode and in some embodiments the electrochemical hydrogen ion sensor is a membrane electrode.
08/28/14
20140238444
new patent Method for cleaning microfluidic device and cleaning liquid
The present invention provides a cleaning method by which the performance of a microchip can be recovered and a cleaning liquid. A method for cleaning a microfluidic device comprising: cleaning a channel that is formed in the microfluidic device, has a surface having a polymer coating, and has been brought into contact with a sample containing nucleic acid and/or protein, by bringing the channel into contact with a cleaning liquid comprised only of an organic solvent having solubility in at least the same volume of water at 25° c., or a cleaning liquid containing 50 vol % or more of the organic solvent in a buffer solution.
08/21/14
20140237689
Metabolic regulators
The present invention provides metabolic regulators, which are proteins (such as fusion proteins, truncated proteins or full-length proteins) that bind to specific metabolites and which can be used to control the availability of the metabolites in cells, particularly plant cells. Proteins of the invention include one or more metabolic regulator proteins, can be truncated or full length, can further comprise a transmembrane domain or lipoylation site or can further comprise a transit peptide.
08/21/14
20140237687
Plants having enhanced yield-related traits and a method for making the same
The present invention provides a method for enhancing various economically important yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a patl (patellin) polypeptide, a prp38 (precursor rna processing factor 38) polypeptide, an ada2 (adaptor 2) polypeptide, a gata-like polypeptide, or a wd40 repeat (wdr) 23-like polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a patl polypeptide, a prp38 polypeptide, an ada2 polypeptide, a gata-like polypeptide, or a wdr23-like polypeptide, which plants have improved yield-related traits relative to corresponding wild type plants or other control plants.
08/21/14
20140237683
Expression enhancing intron sequences
The invention relates to methods for the identification and use of introns with gene expression enhancing properties. The teaching of this invention enables the identification of introns causing intron-mediated enhancement (ime) of gene expression.
08/21/14
20140237632
Rapidly maturing fluroscent proteins and methods for using the same
Nucleic acid compositions encoding rapidly maturing fluorescent proteins, as well as non-aggregating versions thereof (and mutants thereof) as well as the proteins encoding the same, are provided. The proteins of interest are proteins that are fluorescent, where this feature arises from the interaction of two or more residues of the protein.
08/21/14
20140237631
Neurovirulent strain of the west nile virus and uses thereof
Neuroinvasive and neurovirulent strain of the west nile virus, named is-98-st1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.. .
08/21/14
20140235845
Sequence amplification with loopable primers
The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers.
08/21/14
20140235844
Short interfering rna (sirna) analogues
The present invention is directed to novel double-stranded short interfering (sirna) analogues comprising locked nucleic acid (lna) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as rna interference (rnai).
08/21/14
20140235842
Convenient and efficient purification method for chemically labeled nucleic acids
In particular, the present invention relates to a convenient method for purifying labeled nucleic acids in a fast manner with high efficiency from a mixture of unreacted hydrophobic chemical probes, unreacted nucleic acids and labeled nucleic acids, comprising the steps of reacting hydrophobic chemical probe and nucleic acids in an aqueous solution to prepare a reacted solution; adding organic solvent to the reacted solution and stirring it to obtain a mixed solution; and centrifuging the mixed solution and removing organic solvent phase.. .
08/21/14
20140235841
Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsrna) having specific biological activities, which includes acting as a selective agonist for activation of the toll-like receptor 3. Its “rugged” molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation).
08/21/14
20140235833
Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same
The present invention relates to an isolated antibody against her1, an isolated antibody against cd147, an isolated antibody against cd73, and an isolated antibody against epcam; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies.
08/21/14
20140235826
Optically-based stimulation of target cells and modifications thereto
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule.
08/21/14
20140235695
Modulation of hsp47 expression
Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (sina), short interfering rna (sirna), double-stranded rna (dsrna), micro-rna (mirna) or short hairpin rna (shrna)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47.
08/21/14
20140235693
Serpina1 sirnas: compositions of matter and methods of treatment
The technology described herein relates to double-stranded ribonucleic acid (dsrna) compositions targeting the serpinal gene, and methods of using such dsrna compositions to inhibit expression of serpinal. In one embodiment, an irna for inhibiting expression of a serpinal gene includes at least two sequences that are complementary to each other.
08/21/14
20140235607
Compositions and methods for treating and preventing coronary heart disease
The invention pertains to a method of determining a statin dosage for an individual in need of treatment with a statin, comprising determining a slco1b1 genotype from a nucleic acid sample of the individual, said genotype comprising the presence or absence of the slco1b1-056 polymorphism, and determining an apoe genotype or phenotype identifying an apoe polymorphism selected from the group consisting of apoe2, apoe3, apoe4, and any combination thereof, wherein the combination of a slco1b1 genotype identifying the presence of the slco1b1-056 c polymorphism and the apoe genotype or phenotype identifying one of the apoe3/4 or apoe4/4 genotypes indicates the statin dosage.. .
08/21/14
20140235605
Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection..
08/21/14
20140235508
Nucleic acid linker
A nucleic acid linker is for producing a complex of mrna and a protein encoded by that mrna, comprising one 3′-terminal region and two branched 5′-terminal regions, wherein the 3′-terminal region comprises a single-stranded polynucleotide segment able to hybridize with the sequence on the 3′-terminal side of the mrna, and an arm segment that branches off from the single-stranded polynucleotide segment and has a linking segment with the protein on the terminal thereof, and one of the two 5′-terminal regions has a binding site with the 3′-terminal of the mrna.. .
08/21/14
20140235492
Methods for preparing single domain antibody microarrays
The present invention relates to a method for preparing sd ab microarray comprising the step consisting of: —i) providing a host cell capable of expressing a biotinylation enzyme —ii) transforming said host cell with a nucleic acid encoding for a fusion protein wherein a single domain antibody is fused at its carboxy terminal end to a biotinylation peptide —iii) culturing said host cell in presence of biotin in such a way that said fusion protein and biotinylation enzyme are expressed, resulting in biotinylation of said fusion protein —iv) lysing said host cell as cultured at step iii) —v) spotting the lysate obtained at step iv) on a solid sup port coated with an agent selected from the group consisting of avidin, streptavidin and/or any art known derivative of these agents a further object of the invention relates to a sd ab microarray obtainable by the method of the invention.. .
08/21/14
20140235485
Methods and devices for amplification of nucleic acid
The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a preferred embodiment, a plurality of groups of amplified product are generated on the surface, each group positioned in different (typically predetermined) locations on said surface so as to create an array..
08/21/14
20140235483
Parallel determination of competitive binding and target specificity of a binding compound library by high-throughput dna sequencing
The invention is directed to a method for analyzing the competitive binding and target (or ligand) specificity of large numbers of candidate binding compounds with respect to a predetermined reference compound. That is, the invention provides a method for essentially conducting a massively parallel elisa on each member of an entire library of candidate binding compounds at the same time.
08/21/14
20140235477
Measurement and monitoring of cell clonality
Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion..
08/21/14
20140235476
Multivalent binding protein compositions and methods for identifying variants of same
Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., dvd-fab or dvd-ig molecules) and the use of these libraries for the screening of multivalent binding proteins using cell surface display technology (e.g., yeast display).. .
08/21/14
20140235470
Multiplex nucleic acid detection methods
Methods for multiplex ligation-dependent probe amplification include (a) providing a sample tissue to query different target nucleic acids, (b) providing different probe sets for each of the target nucleic acids, each probe set including a first locus specific probe having a first adapter sequence and a first target specific portion and a second locus specific probe having a second adapter sequence, and a second target specific portion adjacent to the first target specific portion, (c) hybridizing the probe sets to the target sequences to form hybridization complexes, (d) ligating the hybridization complexes to form ligated probes, (e) amplifying the ligated probes to form amplicons, the amplifying step being carried out with a first universal primer including a region complementary to the first adapter sequence and a second universal primer including a region complementary to the second adapter sequence, and (f) detecting the amplicons in a detection system by sequencing each of the amplicons.. .
08/21/14
20140235464
Detection and quantification of biomolecules using mass spectrometry
The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry.
08/21/14
20140235463
Methods and apparatus for measuring analytes
Methods and apparatus relating to fet arrays including large fet arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions..
08/21/14
20140235462
Methods and compositions for nanostructure-based nucleic acid sequencing
Provided herein are nanostructure-based sequencing methods and systems.. .
08/21/14
20140235461
Algorithms for sequence determinations
The invention provides methods of determining a consensus sequence from multiple raw sequencing reads of a nucleic acid target. The nucleic acid target includes an anchor segment of known sequence and an adjacent segment of unknown sequence.
08/21/14
20140235460
Quantitative nuclease protection assay (qnpa) and sequencing (qnps) improvements
The present disclosure provides an improvement to quantitative nuclease protection assay (qnpa) and quantitative nuclease protection sequencing (qnps) methods. The disclosed methods use nuclease protection probes (npps) that include 5′-end and/or 3-end flanking sequences, which provide a universal hybridization and/or amplification sequence.
08/21/14
20140235452
Methods and apparatus for measuring analytes
Methods and apparatus relating to fet arrays including large fet arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions..


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