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Nucleic Acid

Nucleic Acid-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces
Janssen Biotech, Inc.
May 24, 2018 - N°20180143203

Protein scaffolds and scaffold libraries based on a fibronectin type iii (fn3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.. .
NEW Method for detecting differentially methylated cpg islands associated with abnormal state of human body
Beijing Shijitan Hospital, Capital Medical University
May 24, 2018 - N°20180143198

Disclosed is a method for detecting differentially methylated cpg islands associated with an abnormal state of a human body, characterized by detecting very minute amounts of methylated cpg short tandem nucleic acid sequences in highly fragmented dna samples with genome scale, identifying differentially methylated cpg islands associated with abnormal state of human body and determining the corresponding abnormal state of ...
NEW Membrane assay method
Axis-shield Asa
May 24, 2018 - N°20180143183

The present invention provides an assay method for a cell-containing body sample, said method comprising treating said sample under conditions whereby to cause cell lysis, preferably by means of a detergent; and subjecting the thus-generated lysed sample to conditions causing the cleavage of nucleic acid molecules. The invention additionally provides the use of nucleic acid cleavage conditions in enhancing a ...
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NEW Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Novozymes A/s
May 24, 2018 - N°20180142312

The present invention relates to polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules..
NEW Methods and compositions for detecting zika virus in semen
Genetics & Ivf Institute
May 24, 2018 - N°20180142310

Provided herein is a highly sensitive and robust method for zika detection in semen, as well as related compositions. The method can include: (a) extracting nucleic acids from a human semen sample; (b) detecting zika virus nonstructural protein 5 (ns5) mrna using real-time reverse-transcription polymerase chain reaction (rrt-pcr); and (c) simultaneously, in the rrt-pcr, detecting human beta-actin mrna as positive control..
NEW Compositions and methods for screening solid tumors
Quest Diagnostics Investments Incorporated
May 24, 2018 - N°20180142304

The present technology relates to methods for determining whether a patient diagnosed with breast cancer, colorectal cancer, melanoma or lung cancer will benefit from or is predicted to be responsive to treatment with an individual therapeutic agent or a specific combination of therapeutic agents. These methods are based on screening a patient's solid tumors and detecting alterations in target nucleic ...
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NEW Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna
Medical College Of Wisconsin, Inc.
May 24, 2018 - N°20180142296

This invention relates to methods and compositions for assessing an amount of non-native nucleic acids in a sample, such as from a subject. The methods and compositions provided herein can be used to determine risk of a condition, such as transplant rejection, in subject..
NEW Method for authenticating active pharmaceutical ingredients
Apdn (b.v.i.) Inc.
May 24, 2018 - N°20180142294

Provided is a method of authenticating an active pharmaceutical ingredient (api). The method includes providing an api or an api component and adding a nucleic acid marker having a nucleic acid marker sequence to produce a marked api or a marked api component.
NEW Nucleic acid-polymer conjugates for bright fluorescent tags
Carnegie Mellon University
May 24, 2018 - N°20180142288

A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains.
NEW Multiplex analysis of gene expression in individual living cells
The General Hospital Corporation
May 24, 2018 - N°20180142284

The technology as disclosed herein relates to methods, compositions and kits for multiplex measuring levels of expression of target rna species (e.g., mrna and non-coding rnas) in single, living cells. Aspects of the invention relate to, in part, a duplex-binding protein which is labeled with a fret dye, and a rna-binding probe, which comprises a spectrally paired fret dye ...
NEW Nucleic acid modifying agents and uses thereof
Biotium, Inc.
May 24, 2018 - N°20180142283

In some aspects, the disclosure provides compounds comprising nucleic acid modifying moieties, such as nucleic acid binding dyes comprising activatable groups. In some aspects, the disclosure provides nucleic acid probes comprising compounds of the disclosure, and methods of making the same.
NEW Generic sample preparation
Roche Molecular Systems, Inc.
May 24, 2018 - N°20180142282

The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner..
NEW Composition for reducing inhibition of nucleic acid amplification
3m Innovative Properties Company
May 24, 2018 - N°20180142280

A composition for reducing the inhibitory effects of contaminants on nucleic acid amplification is provided. The composition includes a plurality of zirconium oxide particles, a non-ionic surfactant, and an organic iron-chelating reagent.
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NEW Microorganisms for the production of 1,4-butanediol
Genomatica, Inc.
May 24, 2018 - N°20180142269

The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (bdo) pathway comprising at least one exogenous nucleic acid encoding a bdo pathway enzyme expressed in a sufficient amount to produce bdo. The invention additionally provides methods of using such microbial organisms to produce bdo..
NEW Targeted lipid particles for systemic delivery of nucleic acid molecules to leukocytes
Ramot At Tel-aviv Unlversity Ltd.
May 24, 2018 - N°20180142261

Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as sirna) to leukocytes (such as t-cells and b-cells). Further disclosed are uses of the targeted lipid based particles for treating leukocytes-associated diseases, such as, cancer..
NEW Late blight resistance gene from solanum americanum and methods of use
Two Blades Foundation
May 24, 2018 - N°20180142254

Compositions and methods and for enhancing the resistance of plants to a plant disease caused by a phytophthora species are provided. The compositions comprise nucleic acid molecules encoding resistance (r) gene products and variants thereof and plants, seeds, and plant cells comprising such nucleic acid molecules.
NEW Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency of ...
Evogene Ltd.
May 24, 2018 - N°20180142252

Provided are isolated polypeptides which are at least 80% homologous to seq id nos: 202-219, 221-292, 295-327, 4064-4175, 4177-4210, 4212-4580, 4582-4603, 4605-4749, 4751-4778, 4780-5223, 5225-5493, 5522-5807, 5812, 5815-5816, 5828-6679, 6689-6690, 6708-6785, 6792-6892 or 6893, isolated polynucleotides which are at least 80% identical to seq id nos: 1-91, 94-201, 328-2317, 2320-2321, 2323, 2326-3835, 3838-3840, 3842-3843, 3848, 3850-3852, 3854, 3856-3953, 3955-4061 or 4062, nucleic acid constructs comprising same, transgenic cells ...
NEW Cis/trans riboregulators
Trustees Of Boston University
May 24, 2018 - N°20180142247

The present invention provides nucleic acid molecules, dna constructs, plasmids, and methods for post-transcriptional regulation of gene expression using rna molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive rna or crrna) within the 5′ untranslated region (5′ utr) of ...
NEW Antisense nucleic acids
May 24, 2018 - N°20180142245

The present invention provides an oligomer which efficiently enables to cause skipping of the 55th, 45th, 50th or 44th exon in the human dystrophin gene.. .
NEW Methods and compositions for enhancing the therapeutic effect of anti-tumor t cells.
The Wistar Institute Of Anatomy And Biology
May 24, 2018 - N°20180142242

Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of forkhead box protein 1 (foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of forkhead box protein 1 (foxp1) expression, viral vectors containing such molecules, t cells transduced with these viruses for adoptive therapies, and any small molecules that bind ...
NEW Method for constructing a plasma dna sequencing library
May 24, 2018 - N°20180142235

The disclosure relates a method for constructing a plasma deoxyribonucleic acid (dna) sequencing library. The method includes: extracting a plasma dna; making the plasma dna ligate to a sequencing linker, and purifying a ligation product; performing polymerase chain reaction (pcr) amplification for the purified ligation product, purifying the pcr amplification product, and obtaining the plasma dna sequencing library, wherein, the ...
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