This page is updated frequently with new Nucleic Acid-related patent applications.
|Blood analyzer, blood analyzing method, and non-transitory computer-readable storage medium|
Disclosed is a blood analyzer including a specimen preparation unit that prepares a measurement specimen by mixing a hemolytic agent that hemolyzes red blood cells, a staining dye that dyes nucleic acids, and a blood specimen; a detector that detects intensity of side scattered light and intensity of fluorescence generated with application of light from the measurement specimen prepared by the specimen preparation unit; and an analysis unit that discriminates white blood cells from giant platelets based on the intensity of side scattered light and the intensity of fluorescence detected by the detector, and counts the white blood cells.. .
|Pca3, pca3 genes, and methods of use|
The present invention relates, in general, to a prostate-specific antigen, pca3. In particular, the present invention relates to nucleic acid molecules coding for the pca3 protein; purified pca3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to pca3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding pca3 proteins; a method of detecting nucleic acids encoding pca3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal..
The Johns Hopkins University
|Compositions and methods for prognosis of ovarian cancer|
Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention farther provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions liar the treatment or prevention of ovarian cancer.
Mor Research Applications
|Systems and methods for treating patients having a genetic predisposition to develop prostate cancer|
Systems and methods for mitigating prostate cancer development are provided. Peripheral blood cells may be evaluated for the presence or quantity of gamma-h2ax foci, and/or for gene alterations encoding a protein with impaired or lack of function, for example, because the encoded protein is truncated, and correlating with prostate cancer development.
Institute For Cancer Research D/b/a The Research Institute Of Fox Chase Cancer Center
|Methods and processes for non-invasive assessment of genetic variations|
Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations. In particular the invention relates to methods and kits for detecting aneuploidy of a fetal chromosome by determining the amounts of differentially methylated regions in each of chromosomes 13, 18 and 21 in circulating cell-free nucleic acid from a human pregnant female..
|Nucleotide analogs for real-time sequencing single molecule|
This invention is to describe nucleotide analogs used in a method for the determination of a nucleic acid sequence. The method involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity..
Personal Genomics, Inc.
|Systems and methods for automated reusable parallel biological reactions|
A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of dna fragments or amplified dna) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material.
|Method of dna sequencing by polymerisation|
The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork.
Universite Pierre Et Marie Curie (paris 6)
|Development of novel detergents for use in pcr systems|
This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (pcr). Methods for preparing the modified detergents are also described..
Life Technologies Corporation
|Detection of target nucleic acid sequences by pto cleavage and extension assay|
The present invention relates to the detection of a target nucleic acid sequence by a ptoce (pto cleavage and extension) assay. The present invention detects a target nucleic acid sequence in which the pto (probing and tagging oligonucleotide) hybridized with the target nucleic acid sequence is cleaved to release a fragment and the fragment is hybridized with the cto (capturing and templating oligonucleotide) to form an extended duplex, followed by detecting the presence of the extended duplex.
Enrichment of nucleic acid targets
Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.. .
Boreal Genomics, Inc.
Sample retrieval and genetic analysis thereof
Retrieval of one or more samples from a pediatric subject for genetic analysis of the subject's nucleic acid is often invasive and inconvenient. Methods for analyzing nucleic acid include non-invasive and/or convenient methods of sample retrieval such as the retrieval of one or more samples for genetic analysis from a patient that may have an infection in conjunction with testing for the infection.
Good Start Genetics, Inc.
Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
The invention is directed to compositions and methods for rapidly detecting, amplifying, and quantitating one or more pathogen-specific nucleic acids in a biological sample, and in particular, samples obtained from patients with sepsis. The invention also provides diagnostic kits containing specific amplification primers, and labeled detection probes that specifically bind to the amplification products obtained therefrom.
Longhorn Vaccines And Diagnostics, Llc
Nucleic acid amplificiation techniques and methods for detecting bacterial infection
Sequence specific dna amplification and analysis techniques are provided. In some aspects, methods of the embodiments comprise amplifying sequence from two regions of a target sequence in the presence of a blocking oligonucleotide (e.g., such as a phosphorothioate-containing oligonucleotide) that hybridizes to the target sequence between the two regions.
Board Of Regents, The University Of Texas System
Method of amplifying nucleic acid sequences
The invention is directed to methods of removing amplicons of non target and/or target nucleic acid sequences having one or more modified (e.g., methylated) nucleotides from a sample wherein the sample comprises the non target nucleic acid and a target nucleic acid sequence to be amplified.. .
Courtagen Life Sciences, Inc.
Methods and compositions for library normalization
The disclosure provides for methods, compositions, and kits for normalizing nucleic acid libraries, for example sequencing libraries.. .
Cellular Research, Inc.
Isolated polynucleotides and polypeptides, and methods of using same for improving plant properties
Provided are isolated polynucleotides which are at least 80% homologous to seq id no: 320, 1-319, 321-473, 836-1652, 1654-3221, 3225-3241, 3243-3630, 3632-4176 or 4177; and isolated polypeptides which are at least 80% homologous to seq id no: 760, 474-759, 761-770, 772-835 and 4178-4195, 4197-4213, 4215-4216, 4218-5334, 5336-5522, 5524-5754, 5756-6215, 6217, 6220-6223, 6230, 6232, 6235-6607, 6609-6614, 6620-7129 or 7130, nucleic acid constructs comprising the isolated polynucleotides, transgenic plants expressing same and methods of using same for increasing abiotic stress tolerance, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, and/or nitrogen use efficiency of a plant.. .
Cotton fibers with increased glucosamine content
An isolated nucleic acid molecule is provided comprising a nucleotide sequence which encodes a glutamine:fructose-6-phosphate amidotransferase from e. Coli which is particularly suitable for expression in cotton plant cells.
Bayer Cropscience Nv
Synthetic chloroplast transit peptides
This disclosure concerns compositions and methods for targeting peptides, polypeptides, and proteins to plastids of plastid-containing cells. In some embodiments, the disclosure concerns chloroplast transit peptides that may direct a polypeptide to a plastid, and nucleic acid molecules encoding the same.
Dow Agrosciences Llc
Nucleic acid fragment binding to target protein
An object of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, particularly, a dna aptamer, having higher specificity and binding activity against a target substance than those of nucleic acid aptamers obtained by conventional methods. The present invention provides a transcribable or replicable nucleic acid aptamer comprising a natural nucleotide and a non-natural nucleotide having an artificial base-pairable artificial base.
Binding-induced dna nanomachines
The invention provides a binding-induced dna nanomachine that can be activated by proteins and nucleic acids. This new type of nanomachine hamesses specific target binding to trigger assembly of separate dna components that are otherwise unable to spontaneously assemble.
The Governors Of The University Of Alberta
Compositions and methods for selective delivery of oligonucleotide molecules to cell types
The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a receptor which can be internalised by the cell in response to the binding of said selectivity agent. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interest and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of contrast agents to the cells for diagnostic purposes..
Nlife Therapeutics, S.l.
Purification of dna-conjugate products
This invention relates to the purification of nucleic acid conjugates, for example for use in dna encoded chemical libraries. Reaction members that comprise nucleic acid conjugate reaction products and nucleic acid or nucleic acid conjugate reactants comprising a first reactive group are contacted with a capping molecule comprising a capture group.
Genomic sequence modification specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
The present invention provides a method of modifying a targeted site of a double stranded dna, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded dna and a nucleic acid base converting enzyme are bonded, with the double stranded dna, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one chain of the double stranded dna in the targeted site.. .
National University Corporation Kobe University
Method and materials for isolation of nucleic acid materials
A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental ph..
Neumodx Molecular, Inc.
Polypeptides having xanthan degrading activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xanthan degrading activity, catalytic domains and polynucleotides encoding the polypeptides and catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and catalytic domains..
Glucoamylase variants and polynucleotides encoding same
The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
Polypeptides having organophosphorous hydrolase activity
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
Il-17a/f heterologous polypeptides and therapeutic uses thereof
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17f designated herein as interleukin 17a/f (il-17a/f). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Anti-activin a antibodies and uses thereof
The disclosure provides compositions and methods relating to or derived from anti-activin a binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin a antibodies that bind human activin a, activin a-binding fragments and derivatives of such antibodies, and activin a-binding polypeptides comprising such fragments.
Compositions and methods for stem cell delivery
This invention provides compositions of matter, articles of manufacture and methods for delivering and/or affixing a stem cell to a target tissue. This invention also provides related nucleic acids, vectors, cells, methods of production, and kits..
Roger Williams Medical Center
Compositions of gm-csf and interleukin fusions for immune modulation and uses related thereto
This disclosure relates to recombinant proteins comprising a gm-csf sequence and an interleukin sequence and nucleic acids related thereto. In certain embodiments, the disclosure relates to recombinant proteins comprises n-terminal sequences that are the result of improved production techniques and uses for treating or preventing autoimmune diseases such as multiple sclerosis and cancer..
Children's Healthcare Of Atlanta, Inc.
Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells
Methods for expressing a polypeptide of interest in an astroglial cell. The methods permit the localization and transport of nucleic acids in microglial exosomes, the reprogramming of astroglial cells to neuronal cells, and the treatment of ischemic stroke or traumatic brain injury patients..
Nomadogen Biotechnologies Inc.
Viral inhibitory nucleotide sequences and vaccines
The invention relates to inhibitory nucleotide signal sequences or “ins” sequences in the genomes of lentiviruses. In particular the invention relates to the agg motif present in all viral genomes.
Institute For Advanced Study
Optically-detectable enzyme substrates and their use
The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample.
Life Technologies Corporation
Nucleic acid sample preparation
The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples..
Biological Dynamics, Inc.
Composition for treating hbv infection
The present invention provides a composition comprising hepatitis b virus (hbv) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such hbv component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors.
Ehrlichial invasin for immuniztion, diagnosis, and cell delivery
Disclosed are vaccines containing one or more immunogenic polypeptides derived from an etpe protein from an ehrlichia sp. Or nucleic acid encoding these polypeptides.
Ohio State Innovation Foundation
Malaria vaccines based on pre-erythrocytic antigens from p. falciparum
The present invention relates to polypeptides or fragments thereof for use as malaria vaccines. It also relates to nucleic acid molecules coding for the polypeptides of the invention.
Methods and compositions for the treatment of glaucoma
Disclosed herein are methods and pharmaceutical compositions for the treatment of glaucoma by interfering with expression of genes, such as p16, in cells of the eye. These methods and compositions employ nucleic acid based therapies..
The Regents Of The University Of California