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Nucleic Acid

Nucleic Acid-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Strategies for high throughput identification and detection of polymorphisms
Keygene N.v.
July 20, 2017 - N°20170206314

The invention relates to a method for identifying one or more polymorphisms in nucleic acid samples, comprising: (a) performing a reproducible complexity reduction on a plurality of nucleic acid samples to provide a plurality of libraries of the nucleic acid samples comprising amplified fragments, wherein the reproducible complexity reduction comprises amplifying fragments of the nucleic acid samples using one or ...
Microrna polymorphisms conferring enhanced drought tolerance in a plant
Syngenta Participations Ag
July 20, 2017 - N°20170204476

Methods of identifying a single nucleotide polymorphism associated with a plant trait and methods of identifying a plant having an improved trait. The plant trait is correlated with at least one single nucleotide polymorphism in a microrna region of a plant genome. Isolated nucleic acids, transgenic plants, and methods of producing the same are also disclosed.
Compositions and methods for detection of candida species
T2 Biosystems, Inc.
July 20, 2017 - N°20170204475

The invention features compositions and methods for the detection of candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in candida species and can be used in a variety of detection assays, such as fluorescence based assays or nmr based assays. The compositions ...
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Multiplexed nucleic acid target identification by strucutre based probe cleavage
Roche Molecular Systems, Inc.
July 20, 2017 - N°20170204462

The present invention provides for novel methods and compositions for nucleic acid sequence detection. Unique, identifying cleavage fragments from probes, bound to target nucleic acids, are produced during pcr by the 5′-nuclease activity of the polymerase. The identity of the targets can be determined by identifying the unique cleavage fragments.
System and methods for massively parallel analysis of nucleic acids in single cells
Gigagen, Inc.
July 20, 2017 - N°20170204460

Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a ...
Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, ...
Cornell University
July 20, 2017 - N°20170204459

The present invention relates to a method for the highly specific, targeted capture of regions of human genomes and transcriptomes from the blood, i. E. From cell free circulating dna, exosomes, microrna, circulating tumor cells, or total blood cells, to allow for the highly sensitive detection of mutation, expression, copy number, translocation, alternative splicing, and methylation changes using combined nuclease, ...
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Nucleic Acid Patent Applications
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Isothermal methods for amplifying nucleic acid samples
Tangen Biosciences, Inc.
July 20, 2017 - N°20170204456

The description provides two-stage methods of nucleic acid amplification and detection reactions, which are useful for rapid pathogen detection or disease diagnosis. In particular, the description provides a method comprising a first-stage slow rate amplification reaction followed by a plurality of second-stage fast rate amplification reactions that are simultaneously monitored in real-time, and wherein a rapid rate of amplification is ...
Methods for forensic dna quantitation
Netbio, Inc.
July 20, 2017 - N°20170204453

Described herein are methods and devices for nucleic acid quantification and, in particular, to microfluidic methods and devices for nucleic acid quantification. In certain embodiments methods of quantifying a target nucleic acid without the need for amplification are provided. The methods involve, in some embodiments, allowing a binding agent to become immobilized with respect to the target nucleic acid. In ...
Polypeptides having glucoamylase activity and polynucleotides encoding same
Novozymes North America, Inc.
July 20, 2017 - N°20170204435

The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Targeted modification of rat genome
Regeneron Pharmaceuticals, Inc.
July 20, 2017 - N°20170204430

Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (ltvec) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a ...
Modifying protein production in plants
Universite Laval
July 20, 2017 - N°20170204427

A method for synthesizing a protein of interest within a plant or a portion of a plant is provided. The method involves treating the plant to increase secondary leaf biomass production, followed by introducing one or more than one nucleic acid sequence encoding a protein of interest operatively linked with a regulatory region that is active in the plant, into ...
Blue light-inducible system for gene expression
Board Of Regents, The University Of Texas System
July 20, 2017 - N°20170204421

The present invention provides methods for light-dependent gene regulation using a light-responsive dna-binding protein. Also provided are related nucleic acid molecules, and protein molecules, such as those encoding or comprising the light-responsive dna-binding protein or dna-binding sites recognizing the light-responsive dna-binding protein. Kits using the present light-dependent gene regulation system are further provided by the present invention.
Dsrna for treating viral infection
Arrowhead Pharmaceuticals, Inc.
July 20, 2017 - N°20170204417

The invention relates to double-stranded ribonucleic acids (dsrnas) targeting gene expression of phosphatidylinositol 4-kinase (pi4k), in particular human phosphatidylinositol 4-kinase, catalytic, beta polypeptide (pik4cb) or human phosphatidylinositol 4-kinase, catalytic, alpha polypeptide (pik4ca), and their use for treating infection by positive stranded rna viruses such as hepatitis c virus (hcv). Each dsrna comprises an antisense strand having a ...
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Nucleic Acid Patent Applications
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Antisense nucleic acids
National Center Of Neurology And Psychiatry
July 20, 2017 - N°20170204410

Provided is a drug that allows highly-efficient skipping of exon. The present invention provides an antisense oligomer wherein two or more unit oligomers targeting sequences that are neither consecutive nor overlap with each other in the same exon are connected.
Method for counting number of nucleic acid molecules
Osaka Prefectural Hospital Organization
July 20, 2017 - N°20170204406

The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately. This is a method for highly accurately counting the number of nucleic acid molecules by detecting the read errors that occur when determining a nucleic acid base sequence, wherein ...
Methods, systems, and software for identifying bio-molecules using models of multiplicative form
Codexis, Inc.
July 20, 2017 - N°20170204405

The present invention provides methods for identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. More specifically, some embodiments of the present invention provide methods for building sequence-activity models comprising multiplicative terms and using the models to guide directed evolution. In some embodiments, the sequence-activity models ...
Reducing horizontal gene transfer of functional proteins
Novogy, Inc.
July 20, 2017 - N°20170204401

Disclosed are methods and compositions for reducing horizontal gene transfer of functional proteins. In some embodiments, the risk of horizontal gene transfer of a functional protein is reduced by separately encoding domains of a protein on at least two spatially distinct nucleic acid sequences, where each individual domain alone is non-functional, but co-expression of the encoded domains results in their ...
Nucleic acid preparation method
Life Technologies As
July 20, 2017 - N°20170204398

A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid ...
Thermally stable enzymes, compositions thereof and method of using same
Lehigh University
July 20, 2017 - N°20170204393

Described herein are isolated recombinant proteins having lyase activity and nucleic acid sequences which code therefor; along with methods of expressing, isolating, purifying, and using same.
Polypeptides having protease activity and polynucleotides encoding same
Novozymes A/s
July 20, 2017 - N°20170204392

The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Method for the manufacturing of di-chain proteins for use in humans
Merz Pharma Gmbh & Co, Kcaa
July 20, 2017 - N°20170204391

This invention relates to a novel method for producing di-chain proteins for use in humans from single-chain precursors, including di-chain clostridial neurotoxins. The method comprises the step of expressing a nucleic acid sequence encoding a single-chain precursor comprising a thrombin-cleavage site and the step of cleaving the single-chain precursor with a human factor xa or a human thrombin, particularly a ...
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