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Nucleic Acid

Nucleic Acid-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods of forming nanostructures having low defect density
Micron Technology, Inc.
September 14, 2017 - N°20170263456

A method of forming a nanostructure comprises forming self-assembled nucleic acids on at least a portion of a substrate. The method further comprises contacting the self-assembled nucleic acids on the at least a portion of a substrate with a solution comprising at least one repair enzyme to repair defects in the self-assembled nucleic acids. The method may comprise repeating the ...
Continuous process for performing multiple nucleic acid amplification assays
Gen-probe Incorporated
September 14, 2017 - N°20170261431

A continuous process for performing multiple nucleic acid amplification assays, where at least a portion of a second subset of reaction mixtures are transferred to a heater while a first subset of reaction mixtures are being subjected to conditions for performing a nucleic acid amplification assay. During the process, a plurality of reaction mixtures from the first and second subsets ...
Detection method
Commonwealth Scientific And Industrial Research Organisation
September 14, 2017 - N°20170260585

The present invention relates generally to an array of nucleic acid molecules, the expression profiles of which characterise the anatomical origin of a cell or population of cells within the large intestine. More particularly, the present invention relates to an array of nucleic acid molecules, the expression profiles of which characterise the proximal or distal origin of a cell or ...
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Preservation of information related to genomic dna methylation
Illumina, Inc.
September 14, 2017 - N°20170260581

The present invention relates to compositions, methods and systems for analyzing the methylation state of nucleic acids. Some embodiments relate to a compositions, methods and systems for analyzing the methylation state of dna with a gene array.
Method for improving nucleic acid synthesis reaction
Takara Bio Inc.
September 14, 2017 - N°20170260578

Provided are the following: a method, for improving reactivity of an acid synthesis reaction, comprising a step for adding an ω-amino acid to a reaction solution; a composition, for a nucleic acid synthesis reaction, comprising dna polymerase, reaction buffer, at least one primer, at least one deoxyribonucleoside triphosphate, and an ω-amino acid; and a reaction buffer, ...
Td probe and its uses
Seegene, Inc.
September 14, 2017 - N°20170260576

The present invention relates to a target discriminative probe (td probe) and its uses or applications. The td probe is hybridized with a target nucleic acid sequence through both of the 5′-second hybridization portion and the 3′-first hybridization portion. When the td probe is hybridized with a non-target nucleic acid sequence, both the 5′-second hybridization portion and ...
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Nucleic Acid Patent Applications
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Spot array substrate, method for producing same, and nucleic acid polymer analysis method and device
Hitachi High-technologies Corporation
September 14, 2017 - N°20170260573

In order to reduce the cost of producing a spot array substrate and reduce the cost of nucleic acid polymer analysis, a spot array substrate is used which is produced by preparing a resin substrate 402 having a surface on which an uneven pattern is formed and a plurality of bead sitting positions set in a two-dimensional array within the uneven ...
Detection method for neisseria gonorrhoeae
Atlas Genetics Limited
September 14, 2017 - N°20170260572

A method of detecting the presence of neisseria gonorrhoeae in a sample. The method involves detecting a first target sequence taken from the ngo1642 gene and/or a second target sequence taken from the ngo1012 gene. The method may involve a step of amplifying the target sequence, and may involve hybridising the target sequence to a nucleic acid probe and ...
Preservation of cell-free nucleic acids
Streck, Inc.
September 14, 2017 - N°20170260569

A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while ...
Method for the colorimetric detection of the amplification of a target nucleic acid sequence
Fondazione Istituto Italiano Di Tecnologia
September 14, 2017 - N°20170260568

The invention relates to methods and kits for the detection of the amplification of a target nucleic acid. The methods and kits of the invention are based on the use of colloidal gold nanoparticles functionalized with a first and a second oligonucleotide probe, whose sequences are designed on a universal tag sequence that is incorporated in the amplification product.
Analyte detection on a solid support by nucleic acid amplification coupled to an immunoassay
Ge Healthcare Uk Limited
September 14, 2017 - N°20170260566

Embodiments of the invention provides a method for detection of at least one analyte derived from a sample, comprising the steps of: a) depositing the sample on a surface of a solid support; b) transferring at least a portion of the solid support to a receptacle suitable for performing a specific binding assay for one or more analytes of interest; ...
Propeptide-luciferase fusion proteins and methods of use thereof
Instituto Carlos Slim De La Salud, A.c.
September 14, 2017 - N°20170260565

The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.
Synthesis of long nucleic acid sequences
Integrated Dna Technologies, Inc.
September 14, 2017 - N°20170260558

The invention provides methods for the synthesis of long oligonucleotides, genes and gene fragments. The methods include the manufacture of genes or gene fragments that can be then inserted into a variety of vectors.
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Targeted elimination of bacterial genes
Technology Innovation Momentum Fund (isreal) Limited Partnership
September 14, 2017 - N°20170260546

Provided is a kit or a system including two elements or components. The first component (i) is a selective component including a nucleic acid sequence and at least one proto-spacer. The second component (ii) includes at least one sensitizing component including at least one cas gene and at least one crispr array. At least one spacer of the crispr targets ...
Compositions and methods for fluorescent genetic bar-coding in mammalian cells for enhanced multiplexing capabilities in ...
San Diego State University (sdsu), Dba San Diego State University (sdsu) Research Foundation
September 14, 2017 - N°20170260543

The invention provides cells or populations of cells, including non-human animals or non-human mammals having these cells, where the cells or populations of cells are stably tagged, uniquely identified and genetically barcoded by one or more detectable, e. G., fluorescent, proteins; and methods of making and using them. In alternative embodiments, the invention provides methods for tagging, uniquely identifying or ...
Bacterial resistant transgenic plants having dysfunctional t3ss proteins
Futuragene Israel Ltd.
September 14, 2017 - N°20170260542

A nucleic acid expression vector comprising a nucleic acid sequence encoding a dominant negative t3ss protein is disclosed. The nucleic acid expression vector further comprising a cis acting regulatory element capable of driving transcription of the nucleic acid sequence in a plant cell. Moreover, the dominant negative t3ss protein mediates assembly of a dysfunctional needle complex.
Use of the rd29 promoter or fragments thereof for stress-inducible expression of transgenes in cotton
Bayer Cropscience Nv
September 14, 2017 - N°20170260539

In one aspect, the present application discloses a chimeric gene comprising (a) a first nucleic acid sequence comprising at least 400 consecutive nucleotides of seq id no: 1 or seq id no: 2 or a nucleic acid sequence having at least 80% sequence identity thereto any of which confers stress inducibility on said chimeric gene; (b) a second nucleic acid sequence encoding an expression ...
Nucleic acid constructs for genome editing
Danziger Innovations Ltd.
September 14, 2017 - N°20170260536

A nucleic acid construct is provided. The construct comprises a tobacco rattle virus (trv) sequence and a nucleic acid sequence encoding a single guide rna (sgrna) that mediates sequence-specific cleavage in a target sequence of a genome of interest, wherein the trv sequence is devoid of a functional 2b sequence. Also provided are plant cells comprising the construct and uses ...
Modified antimir-138 oligonucleotides
Agency For Science, Technology And Research
September 14, 2017 - N°20170260526

Disclosed is a modified oligonucleotide capable of reducing or inhibiting one or more activities mir-138. The modified oligonucleotide may comprise at least one locked nucleic acid (lna) and wherein the oligonucleotide is substantially complementary to a nucleotide sequence of mir-138. Also disclosed are pharmaceutical compositions comprising the oligonucleotides, methods of using the oligonucleotides and uses thereof.
Non-liposomal systems for nucleic acid delivery
Protiva Biotherapeutics, Inc.
September 14, 2017 - N°20170260523

The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (snalp) that have a non-lamellar structure and that comprise a nucleic acid (...
High efficiency, small volume nucleic acid synthesis
Geneart Ag
September 14, 2017 - N°20170260521

The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e. G., large nucleic acid molecules ...
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