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Nucleic Acid patents



      
           
This page is updated frequently with new Nucleic Acid-related patent applications. Subscribe to the Nucleic Acid RSS feed to automatically get the update: related Nucleic RSS feeds. RSS updates for this page: Nucleic Acid RSS RSS


Date/App# patent app List of recent Nucleic Acid-related patents
08/21/14
20140237689
 Metabolic regulators patent thumbnailMetabolic regulators
The present invention provides metabolic regulators, which are proteins (such as fusion proteins, truncated proteins or full-length proteins) that bind to specific metabolites and which can be used to control the availability of the metabolites in cells, particularly plant cells. Proteins of the invention include one or more metabolic regulator proteins, can be truncated or full length, can further comprise a transmembrane domain or lipoylation site or can further comprise a transit peptide.
08/21/14
20140237687
 Plants having enhanced yield-related traits and a method for making the same patent thumbnailPlants having enhanced yield-related traits and a method for making the same
The present invention provides a method for enhancing various economically important yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a patl (patellin) polypeptide, a prp38 (precursor rna processing factor 38) polypeptide, an ada2 (adaptor 2) polypeptide, a gata-like polypeptide, or a wd40 repeat (wdr) 23-like polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a patl polypeptide, a prp38 polypeptide, an ada2 polypeptide, a gata-like polypeptide, or a wdr23-like polypeptide, which plants have improved yield-related traits relative to corresponding wild type plants or other control plants.
08/21/14
20140237683
 Expression enhancing intron sequences patent thumbnailExpression enhancing intron sequences
The invention relates to methods for the identification and use of introns with gene expression enhancing properties. The teaching of this invention enables the identification of introns causing intron-mediated enhancement (ime) of gene expression.
08/21/14
20140237632
 Rapidly maturing fluroscent proteins and methods for using the same patent thumbnailRapidly maturing fluroscent proteins and methods for using the same
Nucleic acid compositions encoding rapidly maturing fluorescent proteins, as well as non-aggregating versions thereof (and mutants thereof) as well as the proteins encoding the same, are provided. The proteins of interest are proteins that are fluorescent, where this feature arises from the interaction of two or more residues of the protein.
08/21/14
20140237631
 Neurovirulent strain of the west nile virus and uses thereof patent thumbnailNeurovirulent strain of the west nile virus and uses thereof
Neuroinvasive and neurovirulent strain of the west nile virus, named is-98-st1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.. .
08/21/14
20140235845
 Sequence amplification with loopable primers patent thumbnailSequence amplification with loopable primers
The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers.
08/21/14
20140235844
 Short interfering rna (sirna) analogues patent thumbnailShort interfering rna (sirna) analogues
The present invention is directed to novel double-stranded short interfering (sirna) analogues comprising locked nucleic acid (lna) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as rna interference (rnai).
08/21/14
20140235842
 Convenient and efficient purification method for chemically labeled nucleic acids patent thumbnailConvenient and efficient purification method for chemically labeled nucleic acids
In particular, the present invention relates to a convenient method for purifying labeled nucleic acids in a fast manner with high efficiency from a mixture of unreacted hydrophobic chemical probes, unreacted nucleic acids and labeled nucleic acids, comprising the steps of reacting hydrophobic chemical probe and nucleic acids in an aqueous solution to prepare a reacted solution; adding organic solvent to the reacted solution and stirring it to obtain a mixed solution; and centrifuging the mixed solution and removing organic solvent phase.. .
08/21/14
20140235841
 Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity patent thumbnailDouble-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsrna) having specific biological activities, which includes acting as a selective agonist for activation of the toll-like receptor 3. Its “rugged” molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation).
08/21/14
20140235833
 Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same patent thumbnailMethod of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same
The present invention relates to an isolated antibody against her1, an isolated antibody against cd147, an isolated antibody against cd73, and an isolated antibody against epcam; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies.
08/21/14
20140235826
Optically-based stimulation of target cells and modifications thereto
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule.
08/21/14
20140235695
Modulation of hsp47 expression
Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (sina), short interfering rna (sirna), double-stranded rna (dsrna), micro-rna (mirna) or short hairpin rna (shrna)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47.
08/21/14
20140235693
Serpina1 sirnas: compositions of matter and methods of treatment
The technology described herein relates to double-stranded ribonucleic acid (dsrna) compositions targeting the serpinal gene, and methods of using such dsrna compositions to inhibit expression of serpinal. In one embodiment, an irna for inhibiting expression of a serpinal gene includes at least two sequences that are complementary to each other.
08/21/14
20140235607
Compositions and methods for treating and preventing coronary heart disease
The invention pertains to a method of determining a statin dosage for an individual in need of treatment with a statin, comprising determining a slco1b1 genotype from a nucleic acid sample of the individual, said genotype comprising the presence or absence of the slco1b1-056 polymorphism, and determining an apoe genotype or phenotype identifying an apoe polymorphism selected from the group consisting of apoe2, apoe3, apoe4, and any combination thereof, wherein the combination of a slco1b1 genotype identifying the presence of the slco1b1-056 c polymorphism and the apoe genotype or phenotype identifying one of the apoe3/4 or apoe4/4 genotypes indicates the statin dosage.. .
08/21/14
20140235605
Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection..
08/21/14
20140235508
Nucleic acid linker
A nucleic acid linker is for producing a complex of mrna and a protein encoded by that mrna, comprising one 3′-terminal region and two branched 5′-terminal regions, wherein the 3′-terminal region comprises a single-stranded polynucleotide segment able to hybridize with the sequence on the 3′-terminal side of the mrna, and an arm segment that branches off from the single-stranded polynucleotide segment and has a linking segment with the protein on the terminal thereof, and one of the two 5′-terminal regions has a binding site with the 3′-terminal of the mrna.. .
08/21/14
20140235492
Methods for preparing single domain antibody microarrays
The present invention relates to a method for preparing sd ab microarray comprising the step consisting of: —i) providing a host cell capable of expressing a biotinylation enzyme —ii) transforming said host cell with a nucleic acid encoding for a fusion protein wherein a single domain antibody is fused at its carboxy terminal end to a biotinylation peptide —iii) culturing said host cell in presence of biotin in such a way that said fusion protein and biotinylation enzyme are expressed, resulting in biotinylation of said fusion protein —iv) lysing said host cell as cultured at step iii) —v) spotting the lysate obtained at step iv) on a solid sup port coated with an agent selected from the group consisting of avidin, streptavidin and/or any art known derivative of these agents a further object of the invention relates to a sd ab microarray obtainable by the method of the invention.. .
08/21/14
20140235485
Methods and devices for amplification of nucleic acid
The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a preferred embodiment, a plurality of groups of amplified product are generated on the surface, each group positioned in different (typically predetermined) locations on said surface so as to create an array..
08/21/14
20140235483
Parallel determination of competitive binding and target specificity of a binding compound library by high-throughput dna sequencing
The invention is directed to a method for analyzing the competitive binding and target (or ligand) specificity of large numbers of candidate binding compounds with respect to a predetermined reference compound. That is, the invention provides a method for essentially conducting a massively parallel elisa on each member of an entire library of candidate binding compounds at the same time.
08/21/14
20140235477
Measurement and monitoring of cell clonality
Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion..
08/21/14
20140235476
Multivalent binding protein compositions and methods for identifying variants of same
Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., dvd-fab or dvd-ig molecules) and the use of these libraries for the screening of multivalent binding proteins using cell surface display technology (e.g., yeast display).. .
08/21/14
20140235470
Multiplex nucleic acid detection methods
Methods for multiplex ligation-dependent probe amplification include (a) providing a sample tissue to query different target nucleic acids, (b) providing different probe sets for each of the target nucleic acids, each probe set including a first locus specific probe having a first adapter sequence and a first target specific portion and a second locus specific probe having a second adapter sequence, and a second target specific portion adjacent to the first target specific portion, (c) hybridizing the probe sets to the target sequences to form hybridization complexes, (d) ligating the hybridization complexes to form ligated probes, (e) amplifying the ligated probes to form amplicons, the amplifying step being carried out with a first universal primer including a region complementary to the first adapter sequence and a second universal primer including a region complementary to the second adapter sequence, and (f) detecting the amplicons in a detection system by sequencing each of the amplicons.. .
08/21/14
20140235464
Detection and quantification of biomolecules using mass spectrometry
The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry.
08/21/14
20140235463
Methods and apparatus for measuring analytes
Methods and apparatus relating to fet arrays including large fet arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions..
08/21/14
20140235462
Methods and compositions for nanostructure-based nucleic acid sequencing
Provided herein are nanostructure-based sequencing methods and systems.. .
08/21/14
20140235461
Algorithms for sequence determinations
The invention provides methods of determining a consensus sequence from multiple raw sequencing reads of a nucleic acid target. The nucleic acid target includes an anchor segment of known sequence and an adjacent segment of unknown sequence.
08/21/14
20140235460
Quantitative nuclease protection assay (qnpa) and sequencing (qnps) improvements
The present disclosure provides an improvement to quantitative nuclease protection assay (qnpa) and quantitative nuclease protection sequencing (qnps) methods. The disclosed methods use nuclease protection probes (npps) that include 5′-end and/or 3-end flanking sequences, which provide a universal hybridization and/or amplification sequence.
08/21/14
20140235452
Methods and apparatus for measuring analytes
Methods and apparatus relating to fet arrays including large fet arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions..
08/21/14
20140234958
Gene delivery system and method of use
A recombinant replication competent retrovirus for gene deliver and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or tissue-specific ligand or a sequence for transcriptional targeting, or a combination of both a cell- or tissue-specific ligand and a cell- or tissue-specific transcriptional targeting sequence..
08/21/14
20140234943
Viruses lacking epithelial cell receptor entry
The document provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The document also provides methods for using viruses to treat cancer patients.
08/21/14
20140234941
Phosphatidic acid phosphatase gene
The present invention provides a novel phosphatidic acid phosphatase gene. The object of the present invention can be solved by providing a nucleic acid comprising the nucleotide sequence set forth in seq id no: 1, seq id no: 4, or seq id no: 5; a protein comprising the amino acid sequence set forth in seq id no: 2; and mutants thereof..
08/21/14
20140234933
Egvii endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding egvii amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvii, recombinant egvii proteins and methods for producing the same..
08/21/14
20140234932
Bgl7 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding bgl7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl7, recombinant bgl7 proteins and methods for producing the same..
08/21/14
20140234931
Bgl6 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding bgl6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl6, recombinant bgl6 proteins and methods for producing the same..
08/21/14
20140234926
Recombinant anaerobic acetogenic bacteria for production of isoprene and/or industrial bio-products using synthesis gas
This invention provides for recombinant anaerobic acetogenic bacterial cells having one or more nucleic acids whereby isoprene, mevalonate and/or other industrial bio-products are produced in a substantially oxygen-free culture condition using synthesis gas as energy and/or carbon source.. .
08/21/14
20140234924
Variants of glycerol dehydrogenase having d-lactate dehydrogenase activity and uses thereof
The present invention provides methods of designing and generating glycerol dehydrogenase (glydh) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding glydh polypeptide variants having altered function as compared to the parent polypeptide.
08/21/14
20140234918
Polypeptides having peroxygenase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/21/14
20140234910
Methods for nucleic acid manipulation
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor.
08/21/14
20140234909
Dna polymerases with increased 3'-mismatch discrimination
Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
08/21/14
20140234907
Polypeptides having endoglucanase activity and polynucleotides encoding same
Provided are isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/21/14
20140234906
Alpha-amylase variants and polynucleotides encoding same
The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
08/21/14
20140234897
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
Disclosed are isolated polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. Furthermore, nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains are disclosed..
08/21/14
20140234893
Heterologous intron within an immunoglobulin domain
The invention concerns the field of recombinant gene engineering. It concerns novel introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes with heterologous introns, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel intron sequences as heterologous introns..
08/21/14
20140234853
Nucleotide transient binding for sequencing methods
Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (snp) analyses.
08/21/14
20140234851
Modular extracellular sensor architecture for cell-based biosensors
The present invention provides modular extracellular sensors, nucleic acids encoding such sensors, and cells expressing such sensors, and methods of employing such sensors and cells for detecting extracellular ligands. In certain embodiments, the extracellular sensors comprise a ligand binding domain, a transmembrane domain, a protease domain, a protease cleavage site, and a transcription factor.
08/21/14
20140234850
Dna fragment detection method, dna fragment detection kit and the use thereof
The disclosure claims a cleaved deoxyribonucleic acid (dna) detection method, a dna fragment detection kit and use thereof. Wherein, the method includes the steps of: designing primers according to a test site or a test region of the dna fragment; cyclizing the dna fragment to obtain acyclized dna; implementing polymerase chain reaction (pcr) amplification for the cyclized dna by using the primers; and detecting the pcr amplification product.
08/21/14
20140234848
Cryptographic methods using nucleic acid codes
Novel methods and systems for encoding cryptographic information are disclosed. A message can be encoded through a sequence of nucleic acids by assigning a binary value to a pair of nucleic acids, while other nucleic acids can be used for spacing.
08/21/14
20140234845
Organism identification panel
Methods and containers are provided for identifying a species, illustratively a bacterial species. Illustrative methods comprise amplifying various genes in the nucleic acid from the bacterial species in a single reaction mixture using pairs of outer first-stage primers designed to hybridize to generally conserved regions of the respective genes to generate a plurality of first-stage amplicons, dividing the reaction mixture into a plurality of second-stage reactions, each using a unique pair of second-stage primers, each pair of second-stage primers specific for a target bacterial species or subset of bacterial species, detecting which of the second-stage reactions amplified, and identifying the bacterial species based on second-stage amplification.
08/21/14
20140234844
Hybridization compositions and methods using formamide
The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%..
08/21/14
20140234841
Compositions, methods and kits to detect dicer gene mutations
In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a dicer1 polypeptide.. .
08/21/14
20140234838
Square wave thermal cycling
Embodiments disclosed herein relate to methods and systems for analysis of melting temperatures, and particularly to analysis of duplex nucleic acids.. .
08/21/14
20140234834
Method for quantifying human dna
The invention provides for a method for quantifying one or more nucleic acids of a genome in a sample comprising the steps of (a) amplifying a first nucleic acid to be quantified, (b) determining the amount of said first nucleic acid by comparison of the amount of amplification product from said first nucleic acid with at least one amplification product from a second template nucleic acid, (c) wherein said second template nucleic acid was generated using whole genome amplification and wherein the starting concentration of the second template nucleic acid is known.. .
08/21/14
20140234832
Methods and compositions for inhibiting undesired cleaving of labels
The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods.
08/21/14
20140234830
Direct amplification and detection of viral and bacterial pathogens
Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction..
08/21/14
20140234827
Ssat mrna translation repression and activation
The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase (“ssat”), wherein translation of an mrna comprising the encoded ssat has increased basal translation and increased stimulated translation, compared to a wild-type mrna encoding ssat. Methods of use for the nucleic acid are also provided.
08/21/14
20140234373
Methods of promoting immune tolerance
Compositions including a polynucleotide combined with a vehicle and methods of their use to induce a suppressive immune response are provided. In some embodiments the compositions induce an increase in expression of indoleamine 2,3 dioxygenase (ido) enzyme activity in cells.
08/21/14
20140234363
Polypeptides from non-typeable haemophilus influenzae
Polypeptides comprising non-typeable haemophilus influenzae (nthi) amino acid sequences. Over 2500 specific nthi proteins are disclosed.
08/21/14
20140234362
Defensin-antigen fusion proteins
The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (hiv) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection..
08/21/14
20140234352
B7-h3 and b7-h4, novel immunoregulatory molecules
The invention provides novel b7-h3 and b7-h4 polypeptides useful for co-stimulating t cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides..
08/21/14
20140234332
Novel hiv-2 isolate
The invention provides a novel strain of hiv-2 capable of causing immunodeficiency. The invention also provides compositions comprising the nucleic acids and polypeptides characteristic of this hiv-2 virus, antibodies specific for this hiv-2 virus, methods of using these compositions, and methods of detecting hiv-2 virus..
08/21/14
20140234303
Treatment of neurological conditions
The present invention is directed to a method for treating an inflammatory neurodegenerative condition of the cns in a subject comprising administering to said subject a g-csf or g-csfr inhibiting agent selected from the group consisting of an antibody specific for g-csf, a soluble g-csfr or a g-csf-binding portion thereof and a 20 to 30 nucleotide sense or antisense molecule targeted to a nucleic acid molecule encoding g-csf.. .
08/21/14
20140234291
Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
08/21/14
20140234273
Diagnostic assay for tissue transplantation status
The present disclosure relates generally to tissue, including organ, transplantation. Taught herein is a genetic-based diagnostic assay to ascertain the status of a tissue transplantation procedure in a recipient based on a characterization of circulating or other cell free nucleic acid material.
08/21/14
20140234265
Compositions and method for manipulating pim-1 activity in circulatory system cells
The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding the serine/threonine kinase pim-1, and methods for making and using them; including methods for inducing cellular proliferation, and protecting cardiac cells from hypoxia and cellular apoptosis. The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding pim-1, and methods for enhancing the regenerative potential of stem cells in the heart..
08/21/14
20140234221
Antigen-binding proteins comprising recombinant protein scaffolds
Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins in addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided vectors and cells useful for expression of the described proteins are also provided, as are methods of use.. .


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