Nucleic Acid

Nucleic Acid-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Method for producing polymers
May 25, 2017 - N°20170147748

(c) detachment of the nucleic acid fragments from individual reaction areas.
NEW Sparse identity spaces in droplet sequencing
May 25, 2017 - N°20170147746

A method for determining a sequence of a target nucleic acid is described. The method uses a plurality of control oligonucleotides with known sequence and unique identifications to map hybridization signals associated with a plurality of sequencing probes to a loosely packed multi-dimensional dye space, such that a region in the dye space can be associated with one or more ...
NEW Method, computer system and software for selecting tag snp, and dna microarray equipped with nucleic ...
May 25, 2017 - N°20170147745

The present invention provides a selection method of tag snps, for constituting a group of nucleic acid probes corresponding to the tag snps, the tag snps being used for performing imputation of information on snps of human genome by using human genome information, the human genome information including information on a group of snps, the genotypes of the snps being ...
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NEW Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds
May 25, 2017 - N°20170146522

Described herein is-a protein capable of spontaneously forming an isopeptide bond for the development of a peptide tag and binding partner pair wherein the peptide tag and binding partner are capable of covalently binding to each other via an isopeptide bond. Also provided is a method for developing a peptide tag and binding partner pair which are capable of covalently ...
NEW Active chemically-sensitive sensors with correlated double sampling
May 25, 2017 - N°20170146484

Methods and apparatus relating to fet arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
NEW Nucleic acid sequences that can be used as primers and probes in the amplification and ...
May 25, 2017 - N°20170145524

The present invention is related to nucleic acid sequences that can be used in the field of virus diagnostics, more specifically the diagnosis of infections with the aids causing human immuno-deficiency virus (hiv). With the present invention nucleotide sequences are provided that can be used as primers and probes in the amplification and detection of hiv-1 nucleic acid. The oligonucleotide ...
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NEW Method for inspecting chromosome of fetus
May 25, 2017 - N°20170145512

A method for inspecting a chromosome of a fetus includes: a collection step of obtaining maternal blood from a pregnant mother; a concentration step of concentrating nucleated red blood cells in the maternal blood; a sorting step of sorting the nucleated red blood cells in the maternal blood, in which the nucleated red blood cells are concentrated through the concentration ...
NEW Detection of target nucleic acids using hybridization
May 25, 2017 - N°20170145510

The present invention provides detection systems and methods for detection of loci and genomic regions in a sample, including mixed samples, using hybridization to an array.
NEW Methods for profiling and quantitating cell-free rna
May 25, 2017 - N°20170145509

The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of rna in a biological sample, comparing the sample level of rna to a reference level of rna ...
NEW Methods for profiling and quantitating cell-free rna
May 25, 2017 - N°20170145508

The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of rna in a biological sample, comparing the sample level of rna to a reference level of rna ...
NEW Methods for profiling and quantitating cell-free rna
May 25, 2017 - N°20170145507

The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of rna in a biological sample, comparing the sample level of rna to a reference level of rna ...
NEW Breast fibroadenoma susceptibility mutations and use thereof
May 25, 2017 - N°20170145504

The present disclosure provides a method of assaying susceptibility and/or confirming diagnosis of breast fibroadenomas development in a human subject. Preferably, the method comprises the steps of performing a nucleic acid-based assay to analyze an isolated polynucleotide encoding at least exon 2 of med12 gene from a sample acquired from the human subject; and regarding the human subject with greater ...
NEW Genetic polymorphisms associated with rheumatoid arthritis, metods of detection and uses thereof
May 25, 2017 - N°20170145503

The present invention provides compositions and methods based on genetic polymorphisms that are associated with autoimmune disease, particularly rheumatoid arthritis. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules ...
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NEW Bi-directional sequencing compositions and methods
May 25, 2017 - N°20170145500

In some embodiments, methods for obtaining sequence information from a nucleic acid template linked to a support include hybridizing a first primer to a template strand linked to a support, sequencing a portion of the nucleic acid template, thereby forming an extended first primer product that is complementary to a portion of the nucleic acid template, in some embodiments, the ...
NEW Methods for indexing samples and sequencing multiple polynucleotide templates
May 25, 2017 - N°20170145499

The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e. G., human genomes), ...
NEW Arrays of optical devices comprising integrated bandpass filters and methods of production
May 25, 2017 - N°20170145498

Arrays of integrated optical devices and their methods for production are provided. The devices include an integrated bandpass filter layer that comprises at least two multi-cavity filter elements with different central bandpass wavelengths. The device arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing ...
NEW Labeled nucleotide analogs, reaction mixtures, and methods and systems for sequencing
May 25, 2017 - N°20170145496

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
NEW Protected dye-labeled reagents
May 25, 2017 - N°20170145495

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
NEW Nucleic acid ligation systems and methods
May 25, 2017 - N°20170145493

The present disclosure relates to systems and methods for nucleic acid ligation. In particular, the present disclosure provides oligonucleotide adaptors for use in nucleic acid ligation reactions.
NEW Compositions and methods for selection of nucleic acids
May 25, 2017 - N°20170145492

Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e. G., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having ...
NEW Quantification methods to determine initial template concentration by means of asymmetric amplification
May 25, 2017 - N°20170145491

Described is a method for quantifying nucleic acid in a nucleic acid amplification reaction, in which an asymmetric nucleic acid amplification reaction is performed on a sample such that double stranded nucleic acid product is generated in an initial stage of the reaction, and single stranded nucleic acid product is generated in a subsequent stage of the reaction once a ...