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Nuclei patents



      
           
This page is updated frequently with new Nuclei-related patent applications. Subscribe to the Nuclei RSS feed to automatically get the update: related Nuclei RSS feeds. RSS updates for this page: Nuclei RSS RSS


Date/App# patent app List of recent Nuclei-related patents
08/14/14
20140230101
 Enzymes that synthesize zingiberene patent thumbnailEnzymes that synthesize zingiberene
The invention relates to nucleic acids encoding a zingiberene synthase that enables host cells and plants to make zingiberene that is useful in fragrances and for repelling or killing insects. The invention also relates to isolated zingiberene synthases and to methods for making zingiberenes..
08/14/14
20140230100
 Marker associated with resistance to smut in plant belonging to genus saccharum, and use thereof patent thumbnailMarker associated with resistance to smut in plant belonging to genus saccharum, and use thereof
The present invention relates to a marker associated with resistance to smut which is a quantitative trait of sugarcane. Specifically, a marker associated with resistance to sugarcane smut, which consists of a continuous nucleic acid region existing in a region sandwiched between the nucleotide sequence shown in seq id no: 1 and the nucleotide sequence shown in seq id no: 14 or a different similar region, is provided..
08/14/14
20140230098
 Polypeptides having endoglucanase activity and polynucleotides encoding same patent thumbnailPolypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230097
 Polypeptides having xylanase activity and polynucleotides encoding same patent thumbnailPolypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230096
 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same patent thumbnailPolypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140230094
 Yield increase in plants overexpressing the shsrp genes patent thumbnailYield increase in plants overexpressing the shsrp genes
A transgenic crop plant transformed by a serine hydroxymethyltransferase-like stress-related polypeptide (shsrp) coding nucleic acid, wherein expression of the nucleic acid sequence in the crop plant results in the plant's increased root growth, and/or increased yield, and/or increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic crop plants.
08/14/14
20140230087
 Regulatory nucleic acid molecules for enhancing constitutive gene expression in plants patent thumbnailRegulatory nucleic acid molecules for enhancing constitutive gene expression in plants
The present invention is in the field of plant molecular biology and provides methods for production of high expressing constitutive promoters and the production of plants with enhanced constitutive expression of nucleic acids wherein nucleic acid expression enhancing nucleic acids (neenas) are functionally linked to said promoters and/or introduced into plants.. .
08/14/14
20140230083
 Modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins patent thumbnailModular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins
The present invention concerns new modular base-per-base specific nucleic acid binding domains (mbbbd) derived from newly identified proteins from the bacterial endosymbiont burkholderia rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.. .
08/14/14
20140230081
 Polynucleotide, polypeptide, animal model and method for the development of complement system modulators patent thumbnailPolynucleotide, polypeptide, animal model and method for the development of complement system modulators
The present invention is in the field of molecular biology, more particularly, the present invention relates to nucleic acid sequences and amino acid sequences of a hamster c5ar1 and the use of hamster as an animal model for the characterization of complement system modulators within drug discovery.. .
08/14/14
20140228546
 Serum albumin binding proteins patent thumbnailSerum albumin binding proteins
The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.. .
08/14/14
20140228256
Method and kit for constructing plasma dna sequencing library
The disclosure relates a method and a kit for constructing a plasma deoxyribonucleic acid (dna) sequencing library. The method provided by the disclosure includes: extracting a plasma dna; making the plasma dna ligate to a sequencing linker, and purifying a ligation product; performing polymerase chain reaction (pcr) amplification for the purified ligation product, purifying the pcr amplification product, and obtaining the plasma dna sequencing library, wherein, the method does not include the step of performing 5′-terminus phosphorylation for the plasma dna.
08/14/14
20140228254
Methods of nucleic acid amplification and sequencing
Methods for amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least one nucleic acid template comprising the nucleic acid(s) to be amplified or sequenced, wherein said nucleic acid(s) contains at the 5′ end an oligonucleotide sequence y and at the 3′ end an oligonucleotide sequence z and, in addition, the nucleic acid(s) carry at the 5′ end a means for attaching the nucleic acid(s) to a solid support; (2) mixing said nucleic acid template(s) with one or more colony primers x, which can hybridize to the oligonucleotide sequence z and carries at the 5′ end a means for attaching the colony primers to a solid support, in the presence of a solid support so that the 5′ ends of both the nucleic acid template and the colony primers bind to the solid support; (3) performing one or more nucleic acid amplification reactions on the bound template(s), so that nucleic acid colonies are generated and optionally, performing at least one step of sequence determination of one or more of the nucleic acid colonies generated. Solid supports, kits and apparatus for use in these methods..
08/14/14
20140228249
Detection and assay devices and methods of making and using the same
An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described..
08/14/14
20140228247
Sequence-specific analysis of nucleic acids
The invention relates to a method for the sequence-specific analysis of nucleic acids in a sample in which the nucleic acid is present at least partially as a double strand, which method uses electrochemical detection methods (e.g. With [oso4(bipy)]).
08/14/14
20140228234
Target-recognition compositions comprising novel synthetic conjugates for trapping and diagnosis of a target molecule
The invention relates to methods, kits and devices for sensitive and efficient trapping, removing, detecting or quantification of a target compound in or from a substance. More specifically, the invention encompasses the use of at least one target-recognition composition comprising at least one nucleic acid-based aptamer that specifically recognizes and binds the target compound, and at least one dna dendrimer labeled with at least one trapping, partitioning or detectable moiety..
08/14/14
20140228233
Circulating biomarkers for cancer
Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and to determine treatment efficacy. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes.
08/14/14
20140227788
Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering metabolism in a cell using isolated and/or purified polypeptides and nucleic acid sequences from alicyclobacillus acidocaldarius..
08/14/14
20140227763
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227761
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227760
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227756
Egvi endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding egvi amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvi, recombinant egvi proteins and methods for producing the same..
08/14/14
20140227743
Dna polymerases with increased 3'-mismatch discrimination
Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
08/14/14
20140227739
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227738
Polypeptides having protease activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/14/14
20140227729
N-demethyase genes and uses thereof
The invention provides isolated nucleic acid encoding one or more gene products that allow for degradation of caffeine and related structures, and for preparation of intermediates in that catabolic pathway. Further provided are methods of using one or more of those gene products..
08/14/14
20140227724
Nucleic acid construct for use in screening for peptide antibody, and screening method using same
The present invention provides a novel tool for simply screening a candidate molecule for an antibody and a method for screening a candidate molecule for an antibody using the tool. A nucleic acid construct includes: (x) an encoding nucleic acid of an antibody candidate, obtained by inserting an encoding nucleic acid of any peptide into an encoding nucleic acid of an antibody; (y) an encoding nucleic acid of a peptide tag; and (z) an encoding nucleic acid of an aptamer that is bindable to the peptide tag are used.
08/14/14
20140227712
Rapid method for isolating extracellular nucleic acids
The present invention pertains to a method for isolating extracellular nucleic acids from a sample, wherein said sample is optionally stabilized, by binding the extracellular nucleic acids to a solid phase which carries anion exchange groups, comprising the following steps: binding the extracellular nucleic acids to the solid phase in a binding mixture having a first ph which allows binding the extracellular nucleic acids to the anion exchange groups of the solid phase; wherein the sample makes up at least 85% of the volume of the binding mixture; separating the solid phase with the bound extracellular nucleic acids; optionally washing the extracellular nucleic acids; optionally eluting extracellular nucleic acids from the solid phase. The method has the advantage that large sample volumes can be processed and that extracellular nucleic acids can be isolated rapidly with a high yield.
08/14/14
20140227709
Methods of detecting low copy nucleic acids
Methods are provided for detecting low copy nucleic acids of interest in a sample. In one method, a sample comprising a nucleic acid of interest is aliquotted into a plurality of reaction mixtures, at least two of which are single-copy reaction mixtures.
08/14/14
20140227704
Methods for rapid identification and quantitation of nucleic acid variants
There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products..
08/14/14
20140227700
Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients..
08/14/14
20140227691
Nucleic acid isolation methods
The present invention provides methods for selectively enriching a biological sample for short nucleic acids, such as fetal dna in a maternal sample or apoptic dna in a biological sample from a cancer patient and for subsequently analyzing the short nucleic acids for genotype, mutation, and/or aneuploidy.. .
08/14/14
20140227689
Novel methods for quantification of micrornas and small interfering rnas
The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature micrornas and small interfering rnas (sirnas). The invention furthermore relates to methods for monitoring the expression of other non-coding rnas, mrna splice variants, as well as detecting and quantifying rna editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer.
08/14/14
20140227688
Stabilisation and isolation of extracellular nucleic acids
The present invention provides methods, compositions and devices for stabilizing the extracellular nucleic acid population in a cell-containing biological sample using an apoptosis inhibitor, preferably a caspase inhibitor, a hypertonic agent and/or a compound according to formula (1) as defined in the claims.. .
08/14/14
20140227687
Stabilisation and isolation of extracellular nucleic acids
The present invention provides methods, compositions and devices for stabilizing the extracellular nucleic acid population in a cell-containing biological sample using an apoptosis inhibitor, preferably a caspase inhibitor, a hypertonic agent and/or a compound according to formula (1) as defined in the claims.. .
08/14/14
20140227680
Compositions, methods and kits to detect adenovirus nucleic acids
The disclosed invention is related to methods, compositions, kits and isolated nucleic acid sequences for targeting adenovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers.
08/14/14
20140227391
Polypeptides having alpha-glucosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
08/14/14
20140227322
Rabies virus like particle production in plants
A method of producing a virus like particle (vlp) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant.
08/14/14
20140227304
Vaccines for preventing and treating alzheimer's disease
Disclosed herein are vaccines comprising an amyloid beta antigen and a nucleic acid encoding the amyloid beta antigen, or a variant thereof. T cell proliferation can be inhibited and itreg cells can be stimulated in the subject administered the vaccine.
08/14/14
20140227280
Protein complex comprising mcm8 and mcm9 proteins and their use
The composition includes either an isolated protein complex including mcm8 and mcm9 proteins, or nucleic acid molecules coding for the proteins that constitute the complex, or compounds inhibiting the formation and/or the stability, or the activity of the complex, for its use for enhancing or reducing animal, preferably mammal, fertility.. .
08/14/14
20140227275
Methods of treating and diagnosing pancreatitis
The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (panec-1 and panec-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode panec-1 and panec-2, expression vectors for the production of purified panec-1 and panec-2, antibodies capable of binding specifically to panec-1 and panec-2, hybridization probes or oligonucleotides for the detection of panec-1- or panec-2-encoding nucleotide sequences, genetically engineered host cells for the expression of panec-1 and panec-2, diagnostic tests for chemokine activation based on panec-1- and panec-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein..
08/14/14
20140227270
Bispecific anti-cxcr7 immunoglobulin single variable domains
The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting cxcr7 mediated tumour growth..
08/14/14
20140227266
Nogo receptor antagonists
Disclosed are immunogenic nogo receptor-1 polypeptides, nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are nogo receptor antagonist polynucleotides.
08/14/14
20140227257
Monoclonal antibodies that neutralize anthrax protective antigen (pa) toxin
The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (pa) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax pa toxin-binding ability, fully human or humanized antibodies retaining anthrax pa toxin-binding ability, and pharmaceutical compositions including such antibodies.
08/14/14
20140227253
Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof
The present invention relates to antigen binding molecules (abms). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human egfr.
08/14/14
20140227185
Glutathione-based drug delivery system
The invention relates to methods of targeted drug delivery of compounds, including, chemical agents, (poly)peptides and nucleic acid based drugs (like dna vaccines, antisense oligonucleotides, ribozymes, catalytic dna (dnazymes) or rna molecules, sirnas or plasmids encoding thereof). Furthermore, the invention relates to targeted drug delivery of compounds to extravascular and intracellular target sites within cells, tissues and organs, in particular to target sites within the central nervous system (cns), into and across the blood-brain barrier, by targeting to glutathione transporters present on these cells, tissues and organs.
08/14/14
20140227181
Method of labelling a biologically active molecule with 5-fluoro-5-deoxypentose or a 3-fluoro-3-deoxypentose
The invention provides a conjugate of a biologically active molecule and a 5-fluoro-5-deoxypentose or a 3-fluoro-3-deoxypentose, wherein the biologically active molecule is selected from the group consisting of proteins, peptides, nucleic acids, oligosaccharides and polysaccharides.. .
08/14/14
20140227146
System and method for processing biological samples
A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.. .


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This listing is a sample listing of patent applications related to Nuclei for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nuclei with additional patents listed. Browse our RSS directory or Search for other possible listings.
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