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Nuclei patents



      
           
This page is updated frequently with new Nuclei-related patent applications. Subscribe to the Nuclei RSS feed to automatically get the update: related Nuclei RSS feeds. RSS updates for this page: Nuclei RSS RSS


Gel patterned surfaces

Date/App# patent app List of recent Nuclei-related patents
08/28/14
20140245498
 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same patent thumbnailnew patent Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
08/28/14
20140245491
 Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use patent thumbnailnew patent Axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230 and axmi231 delta-endotoxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided.
08/28/14
20140245474
 Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold patent thumbnailnew patent Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold
Methods and materials for modulating cold tolerance levels in plants are disclosed. For example, nucleic acids encoding cold tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells.
08/28/14
20140245468
 Non-human animals with modified immunoglobulin heavy chain sequences patent thumbnailnew patent Non-human animals with modified immunoglobulin heavy chain sequences
Non-human animals, e.g., mammals, e.g., mice or rats, are provided comprising an immunoglobulin heavy chain locus that comprises a rearranged human immunoglobulin heavy chain variable region nucleotide sequence. The rearranged human immunoglobulin heavy chain variable region nucleotide sequence may be operably linked to a heavy or light chain constant region nucleic acid sequence.
08/28/14
20140245465
 Transgenic bird expressing foreign gene using endoplasmic reticulum chaperone promoter patent thumbnailnew patent Transgenic bird expressing foreign gene using endoplasmic reticulum chaperone promoter
An aim is to produce a suitable foreign protein in egg white in transgenic birds at levels equivalent to or higher than the expression levels achieved using an ovalbumin promoter or an actin promoter, and to reduce the great burden on birds by reducing the expression at sites other than the oviduct while achieving expression sufficient to predict the expression levels before the birds reach sexual maturity. Provided is a transgenic bird containing a nucleic acid base sequence in chromosome in a cell that forms the oviduct, the sequence containing: (a) an avian endoplasmic reticulum chaperone promoter; and (b) a nucleic acid base sequence encoding a suitable foreign protein, functionally linked to the promoter.
08/28/14
20140243503
 Fgf21 mutants and uses thereof patent thumbnailnew patent Fgf21 mutants and uses thereof
The invention provides nucleic acid molecules encoding fgf21 mutant polypeptides, fgf21 mutant polypeptides, pharmaceutical compositions comprising fgf21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.. .
08/28/14
20140243399
 Engineered nucleic acids and methods of use thereof patent thumbnailnew patent Engineered nucleic acids and methods of use thereof
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger rnas, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing..
08/28/14
20140243397
 Cxcr4 inhibiting carriers for nucleic acid delivery patent thumbnailnew patent Cxcr4 inhibiting carriers for nucleic acid delivery
The present invention generally relates to carriers including polymers and lipids that comprise a cxcr4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a cxcr4 inhibiting moiety.
08/28/14
20140243394
 Compositions and methods for inhibiting expression of a gene from the ebola virus patent thumbnailnew patent Compositions and methods for inhibiting expression of a gene from the ebola virus
The invention relates to a double-stranded ribonucleic acid (dsrna) for inhibiting the expression of a gene from the ebola virus.. .
08/28/14
20140243391
 Phospholipid-detergent conjugates and uses thereof patent thumbnailnew patent Phospholipid-detergent conjugates and uses thereof
The invention relates to novel compounds, in particular novel o-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy..
08/28/14
20140243319
new patent Treatments targeting gamma-synuclein expression levels
A combination treatment taking advantage of the synergistic effect of inhibiting γ-synuclein expression and chemotherapeutic agents to provide improved treatment of cancers, preferably stage iii/iv cancers. A method for identifying improved cancer treatments..
08/28/14
20140243242
new patent Compositions and methods for co-amplifying subsequences of a nucleic acid fragment sequence
The present invention is related to genomic nucleotide sequencing. In particular, the invention describes a single reaction method to co-amplify multiple subsequences of a nucleic acid fragment sequence (i.e., for example, at least two read pairs from a single library insert sequence).
08/28/14
20140243238
new patent Methods of co-detecting mrna and small non-coding rna
Disclosed herein are methods of co-detecting presence of target messenger rna (mrna) and small non-coding rna (for example, mirna) in a sample. The disclosed methods can be used to simultaneously detect mrna and small non-coding rna in a single assay (for example in the same reaction or the same well of a multi-well assay).
08/28/14
20140243235
new patent Peripheral neuropathy diagnosis
Genes whose expression is correlated with the presence of cidp or vasculitic neuropathy are disclosed. Probes and sets of nucleic acids and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject..
08/28/14
20140243234
new patent Nucleic acid compositions, methods and kits for rapid pairing of affinity agents
The present inventions relate to the selection and production of specific proteins or peptides with desired properties. The inventions relate to the agents and methods of identifying select peptides or proteins with specific binding properties or greater enzymatic performance from vast numbers of variants..
08/28/14
20140243232
new patent Nucleic acid complexity reduction
In some embodiments, the present teachings provide compositions, systems, methods and kits for reducing the complexity of nucleotide sequences in a nucleic acid sample comprising the steps: hybridizing a plurality of polynucleotide constructs to at least one blocker oligonucleotide and to at least one capture oligonucleotide, wherein the plurality of polynucleotide constructs include a plurality of polynucleotides each joined to at least one nucleic acid adaptor, wherein the at least one nucleic acid adaptor can hybridize to the at least one blocker oligonucleotide, and wherein the at least one capture oligonucleotide can hybridize to at least a portion of target polynucleotides that are a sub-population of the plurality of polynucleotides, so as to produce a capture duplex.. .
08/28/14
20140243230
new patent Gene expression signature for classification of kidney tumors
The present invention provides a method for classification of kidney tumors through the analysis of the expression patterns of specific micrornas and nucleic acid molecules relating thereto. Classification according to a microrna expression framework allows optimization of treatment, and determination of specific therapy..
08/28/14
20140243224
new patent Gel patterned surfaces
Provided is an array including a solid support having a surface, the surface having a plurality of wells, the wells containing a gel material, the wells being separated from each other by interstitial regions on the surface, the interstitial regions segregating the gel material in each of the wells from the gel material in other wells of the plurality; and a library of target nucleic acids in the gel material, wherein the gel material in each of the wells comprises a single species of the target nucleic acids of the library. Methods for making and using the array are also provided..
08/28/14
20140243222
new patent Multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing of corneal dystrophy and preparation method thereof producing same
A multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing corneal dystrophy, and more particularly to a multi-spot metal-capped nanostructure array nucleic acid chip capable of employing lspr (localized surface plasmon resonance) optical properties, a preparation method thereof, and a multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing bigh3 gene mutations, which can diagnose various corneal dystrophies. The metal-capped nanostructure array nucleic acid chip can be combined with analysis devices, including a light source, a detector, a spectrophotometer and a computer, to provide an lspr optical property-based optical biosensor, and the use of the multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing bigh3 gene mutations allows the simultaneous diagnosis of various corneal dystrophies that are genetic ocular diseases..
08/28/14
20140243216
new patent Methods for separating nucleic acids by size
The present invention pertains to a method for isolating nucleic acids by size from a sample comprising nucleic acids of different sizes using an anion exchange matrix, wherein nucleic acids of a preselected size or a preselected size range are isolated by varying the ph value during elution and/or binding.. .
08/28/14
20140243213
new patent Analysing sequencing bias
The present invention relates to methods for determining the sequence bias of a sequencing technique. Furthermore, the invention relates to methods to reduce or enhance sequence bias during sequencing of nucleic acids via techniques involving adaptor ligations.
08/28/14
20140242704
new patent Pef-ts expression units
The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.. .
08/28/14
20140242701
new patent Chimeric antigen receptor
Provided are a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, the chimeric antigen receptor being characterized in that an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (gitr) is contained as the intracellular domain; a nucleic acid encoding the chimeric antigen receptor; a cell expressing the chimeric antigen receptor; and a method for producing the cell.. .
08/28/14
20140242695
new patent Protein-induced pluripotent cell technology and uses thereof
A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the qq-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous pips cells. Also provided are the pipcs cells formed using this method and uses thereof..
08/28/14
20140242683
new patent Apparatus for selective excitation of microparticles
Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an interference pattern generation module that splits a first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams..
08/28/14
20140242674
new patent Pentose fermentation by a recombinant microorganism
The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.. .
08/28/14
20140242658
new patent Method for production of isoprenoid compounds
The present invention is directed to variant squalene synthase enzymes, including saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds, while still producing sufficient squalene to allow the s.
08/28/14
20140242649
new patent Hybrid organic-inorganic system for producing biofuels
The present invention provides for a system for converting co2 and h2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more nucleic acids encoding genes for a recombinant surface display protein which is capable of tethering an electrocatalyst molecule, such as a cobalt(ii) complex supported by tetradentate polypyridyl ligand 2-bis(2-pyridyl)(methoxy)methyl-6-pyridylpyridine (py4), and enzymes for synthesizing a biologically derived compound, such as an alkane, alcohol, fatty acid, ester, or isoprenoid..
08/28/14
20140242642
new patent Dual cofactor specific ribitol dehydrogenase and use thereof
There are provided a novel ribitol dehydrogenase, a residue determining double coenzyme specificity, and a method for preparing l-ribulose using the same, and more particularly, to a ribitol dehydrogenase producing rare sugars, nucleic acid molecules encoding the same, a vector including the nucleic acid molecules, a transformant including the vector, a mutant of the ribitol dehydrogenase, and a method for preparing l-ribulose using the ribitol dehydrogenase. The ribitol dehydrogenase having double coenzyme specificity, which is derived from zymomonas mobilis, can effectively be used for preparing high-priced rare sugars and an investigation of coenzyme specificity determinants for the ribitol dehydrogenase is applied for all of dedydrogenases as a based technique..
08/28/14
20140242637
new patent Artificial introns
The invention concerns the field of recombinant gene engineering. It concerns novel artificial introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel artificial intron sequences..
08/28/14
20140242636
new patent Regulatable promoter
A method of producing a protein of interest (poi) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a poi under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the poi at a transcription rate of at least 15% as compared to the native pgap promoter, and c) producing and recovering the poi; and further an isolated regulatable promoter and a respective expression system.. .
08/28/14
20140242594
new patent Methods and compositions for preparation of nucleic acids
A method for isolating genomic dna (gdna) from a biological material. In some embodiments, the method includes (a) contacting a sample that contains gdna with a solution of hydroxide and a detergent under conditions and for a time sufficient to degrade a cell wall, a cell membrane, a nuclear membrane, a nucleoprotein, or combinations thereof and/or to denature the gdna; (b) mixing into the solution resulting from step (a) a solution characterized by high salt and sufficient buffering capacity to reduce the ph of the solution to less than 10, thereby producing a neutralized solution; (c) centrifuging the sample at a speed and length of time sufficient to clarify the preparation; and (d) removing insoluble material from the neutralized and clarified preparation, whereby a solution of gdna is produced.
08/28/14
20140242586
new patent Chimeric primers with hairpin conformations and methods of using same
Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5′ of the target-specific primer sequence; a tag sequence 5′ of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed.
08/28/14
20140242577
new patent C-probe libraries for dna target enrichment
Provided herein is a method for enriching a target nucleic acid molecule. In one embodiment, the method may involve hybridizing a c-probe to a strand of a target nucleic acid to produce a complex, enzymatically removing any 3′ overhanging end from the target nucleic acid of the complex to produce a 3′ hydroxyl group at the 3′ end; extending the 3′ end of the first sequence using the oligonucleotide sequence of the c-probe as a template; enzymatically removing any 5′ overhanging end from the target nucleic acid, either before or after the extending step, to produce an 5′ phosphate group at the end of the second sequence; and ligating the 5′ phosphate group at the end of the second sequence to the 3′ hydroxyl group at the end of the first sequence to produce a circular dna molecule that contains the target sequence and the complement of the oligonucleotide sequence..
08/28/14
20140242155
new patent Compounds, compositions, methods, and kits relating to telomere extension
Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment.
08/28/14
20140242154
new patent Compounds, compositions, methods, and kits relating to telomere extension
Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment.
08/28/14
20140242106
new patent Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics..
08/28/14
20140242077
new patent Methods and compositions for modulating an immune response
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as t-cells (e.g., cytotoxic t-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic t-cells) in a subject (e.g., a human subject).


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This listing is a sample listing of patent applications related to Nuclei for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Nuclei with additional patents listed. Browse our RSS directory or Search for other possible listings.
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