|| List of recent Noma-related patents
| Video anomaly detection based upon a sparsity model|
Methods, systems, and processor-readable media for video anomaly detection based upon a sparsity model. A video input can be received and two or more diverse descriptors of an event can be computed from the video input.
The Penn State Research Foundation
| Method for analyzing time series activity streams and devices thereof|
A method, non-transitory computer readable medium, and data manager computing device comprises retrieving a time series data of a monitored asset based on one or more tags in response to a request. Further, a heterogeneous data based on the one or more tags is retrieved.
| Predicting anomalies and incidents in a computer application|
A method for predicting anomalies in a computer application includes during runtime of the computer application, detecting traffic metrics and incident tickets associated with the computer application, the incident ticket indicating an incident might occur in the computer application; calculating a threshold based on absolute values of second order differences associated with the traffic metrics, wherein the threshold is such that when the absolute value of the second order difference associated with the traffic metrics exceeds the threshold, a recall rate rrecall that the computer application is recalled is maximized; obtaining predicted metrics of the computer application in a next time period based on the traffic metrics; and in response to an absolute value of a second order difference associated with the predicted metrics exceeding the threshold, predicting potential anomalies of the computer application in the next time period.. .
International Business Machines Corporation
| Apparatus and monitoring and quantifying progression of a structural anomaly in a high temperature environment of a combustion turbine engine|
Apparatus and method for monitoring and quantifying progression of a structural anomaly, such as crack, over a surface of a component (12) in a high temperature environment of a combustion turbine engine the apparatus may include an electrically-insulating layer (14) formed at least over a portion of the surface of the component of the combustion turbine engine. At least a first detection leg (16) may be disposed on the electrically-insulating layer the first detection leg may be adapted to operate under a desired sensing modality from a bi-modal sensing scheme, such as may be implemented in one sensing modality by way of monitoring changes of an electrical parameter in an electrical circuit formed by the detection leg the sensing scheme may also be implemented by way of imaging radiance energy emitted by the detection leg.
Siemens Energy, Inc.
| Process for producing magnesium oxide|
Process for producing nanomaterials such as graphenes, graphene composites, magnesium oxide, magnesium hydroxides and other nanomaterials by high heat vaporization and rapid cooling. In some of the preferred embodiments, the high heat is produced by an oxidation-reduction reaction of carbon dioxide and magnesium as the primary reactants, although additional materials as reaction catalysts, control agents, or composite materials can be included in the reaction, if desired.
Graphene Technologies, Inc.
| Antibodies against kidney associated antigen 1 and antigen binding fragments thereof|
Novel antibodies and antigen binding fragments that specifically bind to kaag1 and which may be used in the treatment, detection and diagnosis of cancer comprising kaag1-expressing cells are disclosed herein. Cells expressing the antibodies and antigen binding fragments as well as methods of detecting and treating cancer using the antibodies and fragments are also disclosed.
Alethia Biotherapeutics Inc.
| Method for treating epidermoid carcinoma|
Disclosed herein is a method for enhancing the susceptibility of a subject having epidermoid carcinoma toward a tyrosine kinase inhibitor. The method includes administering to the subject an effective amount of a targeted therapy sensitizer and an effective amount of gefitinib.
Johnpro Biotech Inc.
| Zeaxanthin for tumor treatment|
A composition comprising a pharmaceutically effective amount of zeaxanthin or its derivative for use in treating a malignant tumor and a method of using a pharmaceutically effective amount of zeaxanthin or its derivative either alone or together with one or more pharmaceutical agents for treating a malignant tumor. The tumor may be, but is not limited to breast cancer, cervix cancer, colon cancer, cutaneous melanoma, cutaneous squamous carcinoma, hepatocellular carcinoma, lung cancer, osteosarcoma, prostate cancer, and uveal melanoma.
The New York Eye And Ear Infirmary
|Apparatus and recovering from partial insertion of an audio jack|
Apparatus and methods for recovering from an audio jack connection anomaly such as a partial insertion of an audio jack plug with an audio jack receptacle are provided. In an example, a method can include detecting a valid audio jack connection of an audio jack receptacle and an audio jack plug, detecting a change in a state of a detect switch associated with the audio jack connection, applying an oscillating signal to a microphone terminal associated with the audio jack connection, determining the state of the detect switch stays constant for a predetermined time, and isolating the oscillating signal from the microphone terminal..
Fairchild Semiconductor Corporation
|Apparatus and detecting insertion anomaly of an audio jack|
Apparatus and methods for detecting audio jack connection anomalies such as moisture or a partial insertion of an audio jack plug with an audio jack receptacle are provided. In an example, a method for detecting an audio jack insertion anomaly can include ramping on a first detection current source of a detection circuit coupled to a detection terminal of a first audio jack connector, receiving a reference information at a comparator of the detection circuit, receiving a voltage of the detection terminal at the comparator, providing comparison information at an output of the comparator, the comparison information indicative of a comparison of the voltage of the detection terminal and the reverence information, and wherein a first state of the comparison information indicates the audio jack insertion anomaly is due to moisture at the first audio jack connector..
Fairchild Semiconductor Corporation
Method for isolated anomaly detection in large-scale data processing systems
Distributed detection of isolated anomalies, without resulting in overloading an anomaly management system in case of large-scale anomalies occurring and that does not rely on user intervention. Isolated anomalies are detected through insertion of devices rendering a service in different quality of service buckets, and if a device changes from one (or source) quality bucket to another (or destination) quality bucket, the device counts the number of devices in the destination quality bucket that have made the same move..
Predictive anomaly detection of service level agreement in multi-subscriber it infrastructure
A predictive service level agreement (sla) anomaly detection mechanism is provided for multi-subscriber it infrastructure. Also, a method of filtering and prioritizing sla anomaly alerts is provided.
Sodero Networks, Inc.
Composition including material, methods of depositing material, articles including same and systems for depositing material
Methods for depositing nanomaterial onto a substrate are disclosed. Also disclosed are compositions useful for depositing nanomaterial, methods of making devices including nanomaterials, and a system and devices useful for depositing nanomaterials..
Qd Vision, Inc.
Maintenance management device for operating machinery
The maintenance management device 3 includes an error status diagnosis unit 11, a grace period estimation unit 14, a maintenance cost estimation unit 15, and a screen display unit 17. When the error status diagnosis unit 11 has diagnosed the occurrence of an anomaly, the grace period estimation unit 14 estimates a first grace period leading up to the occurrence of a failure.
Hitachi Construction Machinery Co., Ltd.
Sorting two-dimensional nanomaterials by thickness
The present teachings provide, in part, methods of separating two-dimensional nanomaterials by atomic layer thickness. In certain embodiments, the present teachings provide methods of generating graphene nanomaterials having a controlled number of atomic layer(s)..
Method for treating melanoma using a herpes simplex virus and an immune checkpoint inhibitor
The invention relates to methods of treating melanoma using a herpes simplex virus in combination with an immune checkpoint inhibitor.. .
Methods and compositions for treating antiprogestin-resistant cancers
The invention provides methods, pharmaceutical compositions and kits for treating a subject having a carcinoma that is resistant to an antiprogestin. In particular, the methods comprise increasing the molar amount of progesterone receptor isoform a (pr-a) so that it is greater than that of isoform b (pr-b) and administering a therapeutically effective amount of an antiprogestin to the subject, thereby treating the carcinoma..
Consejo Nacional De Investigaciones Científicas Y Técnicas
System and methods of inspecting an object
A system for use in inspecting an object is provided. The system includes at least one array of visual imaging devices configured to capture a plurality of two-dimensional images of the object.
The Boeing Company
Method and system for performance metric anomaly detection in transportation systems
A transportation service data assessment system includes a data set holding f performance metrics for various route components of a transportation service. When the system receives a selected set of operational data parameter labels, as well one or more route components, it develops a matrix of performance metrics corresponding to the operational data and route components, determines a distance between each row of the performance metric matrix to yield a multi-dimensional matrix, and maps the distance data to a 2-d or 3-d coordinate set so that to yield a coordinate matrix.
Application performance monitoring
Various techniques associated with application performance monitoring are disclosed. In some embodiments, a subset of application methods is configured to capture response time metrics, and response time metrics for a prescribed application transaction are computed by summing corresponding response time metrics of methods of the subset that are executed during each transaction invocation.
Appnomic Systems Private Limited
Method and detection of anomalies in integrated parameter systems
A system, method, and tangible computing apparatus is disclosed for the detection of anomalies in an integrated data network. Said system, method and apparatus comprises the creation and construction of a mathematical model that utilizes multi-dimensional mutual information to detect interactions and interrelationships between pairs of data streams and among pluralities of data streams.
Instep Software, Llc
Kit for diagnosing malignant melanoma
Provided is a kit for diagnosing at a high reproducibility, said kit being produced by preparing a monoclonal antibody against gpc3 and a monoclonal antibody against sparc that are superior in quality stability to commercially available and commonly employed antibodies, and using these antibodies.. .
National Cancer Center
Marker sequences for inflammatory prostate diseases, prostate carcinoma and their use
The present invention relates to novel marker sequences for inflammatory prostate diseases, prostate carcinoma and the diagnostic use thereof together with a method for screening of potential active substances for inflammatory prostate diseases, prostate carcinoma by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for inflammatory prostate diseases, prostate carcinoma, in particular a protein biochip and the use thereof..
Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by pd-1, pd-l1, or pd-l2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of pd-1, pd-l1, or pd-l2 are useful for cancer or infection treatment..
Compositions and uses to govern cancer cell growth
The invention relates to composition and a method of using the composition for modulting proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor-associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis.
Massachusetts Institute Of Technology
Treating pancreatic carcinoma with a whole, leech saliva extract
Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of pancreatic carcinoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° c.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech.
Biopep Solutions, Inc.
Method of treating cancer
This invention is directed to the treatment of cancer, particularly ocular melanoma, with a dual inhibitor of met and vegf such as compound 1.. .
Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections
In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication of a virus, by administering artemisinin-related compounds..
Method and treating medical conditions
A method and apparatus for treating a condition in a patient such as bph, irretractable infection, cyst, fibroid, or any mass such as prostate or breast cancer, skin cancer, melanoma, or any other soft tissue cancerous or benign mass, employs a unique, three-dimensional software-controlled electronic amplifier array using arbitrary waveforms that dynamically and proportionally steer electrical currents by using two or more current vector paths, sequentially or simultaneously, through a defined area containing electrically-conductive ionic solutions so as to obtain 100% thermal heating or hyperthermia through the defined area. The condition is treated or a mass is destroyed with a minimally-invasive treatment which requires no radiation or chemotherapy which could be harmful to the patient..
Anomaly detection in a computer network
In one embodiment, a training request is sent to a plurality of nodes in a network to cause the nodes to generate statistics regarding unicast and broadcast message reception rates associated with the nodes. The statistics are received from the nodes and a statistical model is generated using the received statistics and is configured to detect a network attack by comparing unicast and broadcast message reception statistics.
Cisco Technology, Inc.
Antibodies that recognize iapp
The invention provides monoclonal antibody 8a9 and related antibodies. The 8a9 antibody binds to an epitope within residues 1-10 of iapp.
Neotope Biosciences Limited
Methods of using ceo2 and tio2 nanoparticles in modulation of the immune system
Redox-active nps are disclosed that can potentiate innate immunity and stimulate distinct adaptive responses, producing distinct t cell subset polarization outcomes. Nanomaterials that can alter the cellular redox environment through ros modulation can impact human immunology.
Sanofi Pasteur Vaxdesign Corp.
Systems, methods, and media for outputting data based on anomaly detection
Systems, methods, and media for outputting data based on anomaly detection are provided. In some embodiments, a method for outputting data based on anomaly detection is provided, the method comprising: receiving, using a hardware processor, an input dataset; identifying grams in the input dataset that substantially include distinct byte values; creating an input subset by removing the identified grams from the input dataset; determining whether the input dataset is likely to be anomalous based on the identified grams, and determining whether the input dataset is likely to be anomalous by applying the input subset to a binary anomaly detection model to check for an n-gram in the input subset; and outputting the input dataset based on the likelihood that the input dataset is anomalous..
Predicting bladder cancer responsiveness to bcg
Bacillus calmette-guerin (bcg) administration plays a central role in managing carcinoma in situ of the bladder. Unfortunately, recurrence or progression of disease is seen in up to 30% of treated patients.
Memorial Sloan-kettering Cancer Center
Methods and system for detecting melanoma
Use of the method for detecting melanoma in skin samples is also disclosed.. .
Simultaneous detection of cannibalism and senescence as prognostic marker for cancer
The present inventors show that cannibal cells can undergo senescence after entosis in vivo and that the tumor suppressive protein p53 act as a repressor of this phenomenon. They therefore propose new tools to study the molecular pathways involved in the cannibalism process, for example by measuring the expression levels of p53 or splice variants thereof (such as Δ133tp53, tp53β, tp53γ or Δ40tp53), the release of extracellular atp or purinergic p2y2 receptor activity.
Gene expression profiles associated with metastatic breast cancer
A gain-of-function retroviral cdna screen reveals that coco, a secreted antagonist of tgf-β ligands, induces solitary mammary carcinoma cells, which have disseminated to others sites and undergone an extended period of dormancy, to exit from dormancy at lung metastatic sites. Evidence indicates that coco awakens tumor progenitor cells that have extravasated into the lung by inhibiting stroma-derived bone morphogenetic proteins (bmp).
Memorial Sloan-kettering Cancer Center
Translocation and mutant ros kinase in human non-small cell lung carcinoma
In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of sodium-dependent phosphate transporter isoform napi-3b protein (slc34a2) with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The slc34a2-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
Cell Signaling Technology, Inc.
Compounds and methods for kinase modulation, and indications therefor
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of fms, kit, flt3, trka, trkb and trkc kinase protein.
Use of vegfr-3 inhibitors for treating hepatocellular carcinoma
This invention is related to the use of inhibitors of vascular endothelial growth factor receptor 3 for treating hepatocellular carcinoma.. .
Nanocomposite polymer-carbon based nanomaterial filters for the simultaneous removal of bacteria and heavy metals
The disclosed subject matter provides a filter that is modified by a polymer-carbon based nanomaterial nanocomposite intended to significantly enhance the performance of filtration, separation, and remediation of a broad variety of chemicals, heavy metal ions, organic matters, and living organisms. Polymeric materials, such as but not limited to poly-n-vinyl carbazole (pvk), are combined with (1) graphene (g) and/or graphene-like materials based nanomaterials and (2) graphene oxide (go) chemically modified with a chelating agent such as but not limited to edta.
Automated statistics content preparation
Various embodiments are generally directed to automated searching and comparison of game statistics to identify, rank and present statistically significant events related to game play during and/or after a game in automatically generated sentences. An apparatus comprises a processor circuit and storage storing instructions operative on the processor circuit to receive signals conveying a first set of statistical information closely related to play of a first game; search the first set of statistical information for a first set of statistical anomalies; and in response to the first set of statistical anomalies comprising an insufficient number of statistical anomalies, search a second set of statistical information less closely related to play of the first game for a second set of statistical anomalies, and transmit a multitude of sentences describing statistical anomalies of the first and second sets of statistical anomalies to a computing device.
Cbs Interactive Inc.
Molecular design and chemical synthesis of pharmaceutical-ligands and pharmaceutical-pharmaceutical analogs with multiple mechanisms of action
Multi-phase and single-phase chemical reaction schemes have been developed for the synthesis of pharmaceutical-ligand analogs, pharmaceutical-pharmaceutical analogs, and similar molecular-molecular analogs that possess multiple mechanisms of action. The multi-phase organic chemical reaction schemes include relatively mild reaction conditions, high end product yields, and comparatively rapid completion of chemical reactions, which are all of particular utility for the synthesis of preparations including covalent pharmaceutical-receptor ligand or pharmaceutical-immunoglobulin analogs.
Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit raf (e.g., b-raf) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit raf (e.g., braf) activity, to inhibit receptor tyrosine kinase (rtk) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of raf, rtk, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc..
Cancer Research Technology Limited
4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one for use in the treatment of adenoid cystic carcinoma
The present invention describes a method of reducing solid tumors in a subject having an adenoid cystic carcinoma comprising administering a therapeutically effective amount of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-yl]-1h-quinolin-2-one or a pharmaceutically acceptable salt thereof.. .
Fumarylacetoacetate hydrolase (fah)-deficient pigs and uses thereof
Described herein is the generation of fah+/− heterozygote pigs by homologous recombination and somatic cell nuclear transfer, and a method for producing fah−/− homozygote pigs. The fah-deficient pigs of the disclosure can be used for a variety of research and therapeutic purposes, such as for the expansion of human hepatocytes, and as large animal models of hereditary tyrosinemia type 1, cirrhosis and hepatocellular carcinoma..
Mayo Foundation For Medical Education And Research