|| List of recent Noma-related patents
|Drone for collecting images and system for categorizing image data|
A data collection system provides a first computer media for collecting image data, a second computer media for analyzing the image data and locating anomalies in the image data, a third computer media for linking particular image data to address data of the property where the anomaly is present and a fourth computer media for generating a list of pertinent properties having similar anomalies by address. The image data collected by an unmanned aerial vehicle or drone..
|Integrin-blocking polypeptides and uses thereof|
A series of integrin blockers that present strong angiogenesis inhibiting performance, high integrin affinity and integrin-bonding capacity is provided. This series of integrin blockers can be adopted in treatment of solid tumors and rheumatoid arthritis.
|Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors|
The present invention concerns methods for treating a proliferation disorder, such as prostate cancer, basal cell carcinoma, lung cancer, and other cancers, using an inhibitor of the hedgehog pathway (hhp); and methods for monitoring subjects undergoing such treatments based on biomarkers and other criteria predictive of efficacy.. .
|Molecular nets on solid phases|
Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a molecular net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a molecular net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample.
|Compositions and methods for the treatment of prostate carcinoma|
Compositions and methods for the diagnosis, treatment and prevention of prostate cancer, well as for treatment selection.. .
|Dna methylation in colorectal and breast cancer diagnostic methods|
The present invention relates generally to nucleic acid molecules in respect of which changes to dna methylation levels are indicative of the onset or predisposition to the onset of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to dna methylation levels are indicative of the onset and/or progression of a large intestine or breast neoplasm, such as an adenoma or adenocarcinoma.
|Antigen presenting cancer vaccine|
The disclosure provides reagents, methods, and kits, for treating melanoma. The reagent encompasses interferon-gamma (ifn-gamma) responsive melanoma cells, where the cells are autophagic and non-apoptotic melanoma cells, and where the cells express mhc class if.
|Methods, agents and peptides for inhibiting matrix metalloproteinase-2 signaling|
Screening assays and methods of using same for screening to identify modulator agents or compounds that affect matrix metalloproteinase-2 (mmp-2) mediated activation of toll-like receptor-2 (tlr-2) are described herein. Pharmaceutical and immunogenic compositions comprising agents or compounds that modulate mmp-2 mediated activation of tlr-2 are also encompassed.
|Mig-7 as a specific anticancer target|
Aspects of the present invention provide novel mig-7 encoding nucleic acids and mig-7 polypeptides, recombinant dna expression systems and host cells containing same, as well as methods of inhibiting expression of the subject nucleic acid molecules, inhibiting production of the encoded proteins or polypeptides, inhibiting metastasis of a carcinoma cell in a subject (including in humans), inhibiting migration/invasion of and mimicking of normal cells by carcinoma cells in a subject, detecting the presence of a cancer cell (e.g., a migrating/invading cancer cell or carcinoma cell mimic, and tumor neovascularization) in a sample of a subject's tissue or body fluids, and inhibiting the migration/invasion of or endothelial cell mimicking by a placental cell into the blood stream or vessels of a female mammal. Particular aspects relate to novel anti-mig-7 antibodies, diagnostic and/or prognostic methods, and therapeutic methods comprising use of the inventive nucleic acids, polypeptides and antibodies or derivatives thereof..
Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by pd-1, pd-l1, or pd-l2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of pd-1, pd-l1, or pd-l2 are useful for treatment of cancer or infection..
|Treatment of cancer with dihydropyrazino-pyrazines|
Provided herein are methods for treating or preventing head and neck squamous cell carcinoma characterized by deletion of chromosome 11q22 or loss of ataxia telangiectasia mutated expression, comprising administering an effective amount of a dihydropyrazino-pyrazine to a patient having head and neck squamous cell carcinoma characterized by deletion of chromosome 11q22 or loss of ataxia telangiectasia mutated expression.. .
|Method and system for detecting anomalies on satellite navigation signals and hybridization system comprising such a detection system|
A method for detecting anomalies on satellite navigation signals consists in extracting the code error values delivered at the output of the n code discriminators, and comparing the extracted code error values with a same first threshold value corresponding to an acceptable maximum code error value and assigning a confidence index to each navigation signal received on each reception channel i, the confidence index depending on the result of the comparison carried out on the code error values.. .
|Apparatus and method for monitoring the structural integrity of a pipeline by means of a superconducting magnet|
An inspection apparatus (100) for monitoring the structural integrity of a pipeline (101) comprising a superconducting electromagnet (102) suitable for generating a magnetic field (106); a cryostat (103) suitable for containing and preserving said superconducting electromagnet (102) at a low temperature; at least two magnetic conveyors (104′, 104″) connected at opposite ends of the cryostat (103) suitable for conveying the magnetic field (106) generated by the superconducting electromagnet (102) to the wall of the pipeline (101) and facilitating the closing of a magnetic circuit; at least one sensor system (105) for revealing the intensity of the magnetic field (106). A method for monitoring the structural integrity of a pipeline (101) using an inspection apparatus (100) according to the present invention.
|Articles containing non-visible identifying marks formed from nanomaterials and methods utilizing the same|
Identifying marks are often used for authentication and tracking purposes with various types of articles, but they can sometimes be subject to replication or removal by an outside entity, such as a person or group having malicious intent. Carbon nanotubes and other carbon nanomaterials can be used to form identifying marks that are not visible to the naked eye, thereby making the marks more difficult for an outside entity to tamper with.
|Seasonal trending, forecasting, anomaly detection, and endpoint prediction of java heap usage|
Data can be categorized into facts, information, hypothesis, and directives. Activities that generate certain categories of data based on other categories of data through the application of knowledge which can be categorized into classifications, assessments, resolutions, and enactments.
|Vehicle diagnostics and roadside assistance|
Methods and systems for vehicle diagnostics and roadside assistance are disclosed. Specifically, a method to monitor the health of vehicle systems and subsystems and diagnose detected anomalies is provided.
|Automatic vehicle diagnostic detection and communication|
Methods and systems for vehicle diagnostic detection and communication are disclosed. Specifically, a method to monitor the health of vehicle systems and subsystems and diagnose detected anomalies is provided.
|Gene therapy induced pyroptosis for the treatment of tumors|
Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an raav vector that includes a caspase-1 gene or a variant thereof and a schwann cell specific promoter..
|Non-covalent biomolecule immobilization on titania nanomaterials|
A biomolecule immobilization substrate comprising a titania nanotube is provided. Stable undercoordinated titanium sites on the surface of titanium dioxide nanotubes provide for the binding of biomolecules in multiple layers and aggregates.
The presently disclosed subject matter provides methods of characterizing a melanoma in a subject by measuring amounts of one or more rnas, mirnas, and/or polypeptides present in cancer-derived microvesicles isolated from a biological sample from the subject.. .
|Ultrasound phantom models, materials, and methods|
Devices, systems, and methods appropriate for use in medical training that include materials that better mimic natural human tissue are disclosed. In one aspect a polysiloxane mixture for simulating human biological tissue, especially human breast tissue, is disclosed.
|Core-shell quaternary ammonium nanomaterials, methods and applications|
Quaternary ammonium materials may be immobilized onto a metal oxide nanoparticle to provide a fixed-quat nanoparticle material. A particular example uses a silicon alkoxide as a silicon source material to provide a fixed-quat sinp/ng material composition through either acidic or basic hydrolysis of the silicon alkoxide material.
|Antigen presenting cancer vaccine with gamma interferon|
The disclosure provides reagents, methods, and kits, for treating melanoma. The reagent encompasses interferon-gamma (ifn-gamma) responsive melanoma cells, where the cells are autophagic and non-apoptotic melanoma cells, and where the cells express mhc.
|Automatic communication of damage and health in detected vehicle incidents|
Methods and systems for automatic communication of vehicle damage and health of users in detected vehicle incidents are disclosed. Specifically, a method to monitor the health of occupants and detect and identify any occupants experiencing a medical anomaly is provided.
|Conical ultrasonic probe|
An array of ultrasonic transducers in a conical formation emits pulses of ultrasonic simultaneously so that an anomaly of any orientation in a test object can be detected efficiently.. .
|Distributed network anomaly detection|
A network device may include multiple interfaces, each including a local database to store, in a first group of local records, information associated with a first group of data units sent from or received by a first one of the group of interfaces; a global database to store, in a group of global records, information associated with the first group of data units and information associated with a second group of data units sent from or received by a second one of said group of interfaces. The device may include a processor, to manage the local database and the global database; broadcast at least one of the local records to the second one of the group of interfaces; and analyze each of the local records to identify potential anomalies in the first group of data units..
|Procurement process utilizing a light sensor|
A system for managing a procurement process uses an ambient light sensor to detect an operating anomaly regarding at least one light source. A procurement system operatively coupled to the light sensing system receives information indicative of the detected operating anomaly of the at least one light source and, in response thereto, initiates the procurement process to obtain a replacement for the at least one light source..
|Method for quantitative definition of direct hydrocarbon indicators|
Method for automated and quantitative assessment of multiple direct hydrocarbon indicators (“dhi's”) extracted from seismic data. Dhi's are defined in a quantitative way (33), making possible a method of geophysical prospecting based on quantification of dhi anomalies.
|Water enucleation of the prostate|
Embodiments of the present invention provide improved methods and apparatus of treating the prostate. In many embodiments, at least a portion of the prostate is enucleated with a water jet, in order to decrease the invasiveness of the surgery.
|Stilbenoid compound as inhibitor for squamous carcinoma and hepatoma and uses thereof|
The present invention provides a series of derivatives of stilbenoid which are useful as new inhibitory agents against head and neck squamous cell carcinoma (hnscc) and hepatoma.. .
|Cdk9 inhibitors in the treatment of midline carcinoma|
The present invention relates to a cdk9 inhibitor, especially a selective cdk9 inhibitor, for use in treating, ameliorating and/or preventing midline carcinoma. Also corresponding methods for treating, preventing or ameliorating midline carcinoma are subject of the present invention.
|Modulation of pancreatic beta cell proliferation|
Work described herein provides, in one embodiment, a method for increasing proliferation or replication of pancreatic beta cells in a subject in need thereof, comprising administering to said subject an effective amount of an agent that increases the level or activity of hepatocellular carcinoma-associated protein td26 (td26), thereby increasing proliferation or replication of pancreatic beta cells. Such an agent may function by, for example, increasing the level of active td26 in the subject or by increasing the functional activity of td26 in the subject..
|Gene signature for the prediction of nf-kappab activity|
Methods for predicting nf-kappab (nf-kb) activity in a tumor, and more particularly to methods for predicting survival and therapeutic outcome, and selecting therapy in subjects with tumors, e.g., adenocarcinomas, e.g., lung adenocarcinomas and melanomas.. .
|Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume|
Novel antibodies and antigen binding fragments that specifically bind to clusterin are described. In some embodiments, the antibodies block the biological activity of clusterin and are useful in composition in certain cancers, more particularly in cancers, such as endometrial carcinoma, breast carcinoma, hepatocellular carcinoma, prostate carcinoma, a renal cell carcinoma, ovarian carcinoma, pancreatic carcinoma, and colorectal carcinoma.
|Induction of thyroid iodide-handling gene expression in human cancers|
Dual suppression of the map kinase and pi3k/akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cell proliferation, transformation and invasion, induction of g0/g1 cell cycle arrest and, importantly, cell apoptosis. Remarkably, suppression of either pathway induces the expression of thyroid iodide-handling genes and dual suppression of the two pathways synergistically and robustly induces expression of these genes, accompanied by uptake of radioiodine in the cells.
|In-situ battery monitoring system|
The present disclosure provides a system, method, and apparatus for battery monitoring. In one or more embodiments, the disclosed method involves injecting at least one test signal into a battery, and receiving at least one response signal from the battery.
|Smart solenoid compound gun driver and automatic calibration method|
A device for calibrating a spray gun and an associated method are provided. The spray gun has a nozzle that is opened and closed by moving an internal needle out of and into sealing engagement with the nozzle.
|Data-agnostic anomaly detection|
This disclosure presents computational systems and methods for detecting anomalies in data output from any type of monitoring tool. The data is aggregated and sent to an alerting system for abnormality detection via comparison with normalcy bounds.
|Universal smart energy transformer module|
A universal smart energy transformer module (usetm) that uses an array of sensors to monitor and measure characteristics of the electrical power delivered and utilized at a location, along with other conditions in the area surrounding the location. The invention then uses the data from these sensors to determine the condition and performance of the transformer (for example, its input and output, power quality etc.) and also to identify any anomalies detected within the local power system that could threaten reliable electric supply on the electric grid, or pose a danger to people.
|Layer structure for epidermal radionuclide therapy|
Disclosed is a layer structure for epidermal radionuclide therapy (brachytherapy) of a patient comprising, from a patient's view, a proximal adherent layer for applying the layer structure on the skin surface to be treated of a patient; a flexible, transparent carrier layer that from a patient's view is located in a distal direction on the adherent layer; and at least one radionuclide-containing emission layer located on the carrier layer, the adherent layer and the carrier layer with regard to their components and thickness being formed such that they are essentially transparent for β and γ radiation. The layer structure is suited particularly for radiotherapeutic treatment of the basal-cell carcinoma (bcc) and the squamous cell carcinoma (scc).
|Methods for early detection of esophageal cancer|
The present invention relates to a method for screening, predicting or prognosing esophageal adenocarcinoma/high grade dysplasia in a subject.. .
|Mitigation of plugging in hydroprocessing reactors|
The behavior of a monitored condition over time for a reactor or reaction system can be analyzed using groupings or windows of data to identify anomalous features in the time-average values. Anomalous features can be identified based on a threshold value generated from the analysis.