|| List of recent Noma-related patents
| Scalable log analytics|
Large amounts of unstructured log data generated by software and infrastructure components of a computing system are processed and analyzed in real time to identify anomalies and potential problems within the computing system. A log analytics module reduces both the volume and level of detail of log data by first classifying log messages into message types based on their content similarity.
| Systems and methods for asynchronous schema changes|
This disclosure provides systems and methods for updating database servers with schema changes to avoid concurrency anomalies. The system may receive a snapshot of a table to be updated with a new schema, wherein the snapshot is taken at a given time, and wherein the table includes a number of rows.
| Method and apparatus for normalizing and predicting time series data|
A computer implemented method and apparatus for normalizing and predicting time series data. The method comprises accessing collected data comprising a plurality of intervals; defining a variation for each interval in the plurality of intervals, wherein each variation is a cost value; clustering the cost values, wherein clustering identifies anomalies in the collected data; correcting the anomalies in the collected data; and creating a set of normalized data from the corrected data..
| Systems and methods for data mining and modeling|
Techniques for prediction of financial instrument returns, identifying statistical history, the discovery of pricing anomalies, and financial instrument visualization are disclosed. In one particular exemplary embodiment, the techniques may be realized as a method for identifying financial instrument returns and pricing anomalies including matching, using at least one computer processor one or more portions of current market data associated with a financial instrument with historical market data, averaging outcomes of matched historical market data, and providing a probabilistic outcome for financial instrument returns, pricing anomalies, or other metrics based on the matched historical market data and the current market data.
| Data analytics platform using social network and web data to identify a pattern or anomaly among relevant events and entities|
Disclosed is a technique that intakes data from an initial court case and relevant court cases to identify relevant events and entities (e.g. An individual or an organization).
| Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas|
The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or rnas or vectors encoding them which reduce expression of downregulated in renal cell carcinoma (drr) in tumor cells, and inhibit malignant glioma cell invasion..
| Compositions and methods for treating cancer|
The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a wee1 inhibitor and a chk1 inhibitor, wherein the wee1 inhibitor is mk-1775 or a pharmaceutically acceptable salt thereof, or mk-3652 or a pharmaceutically acceptable salt thereof, and the chk1 inhibitor is mk-8776 or a pharmaceutically acceptable salt thereof, or sch900444 or a pharmaceutically acceptable salt thereof.. .
| Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer|
The present invention describes a method utilizing a set of genes or gene products whose altered expression in cancer tissue, particularly head and neck cancer and other carcinomas, or its adjacent normal tissues predicts (a) probability of recurrence in time after treatment (b) sensitivity or resistance to therapies or (c) probability of metastasis at the time of initial discovery of the tumor. Furthermore, the invention describes methods of determining the molecular signature in tumor tissues, tissues adjacent to the tumor, or in saliva by using dna microarray techniques, quantitative real-time pcr, immunohistochemistry or other methods that are used for determining gene or gene product expression levels..
| Biomarkers of high-grade serious ovarian carcinomas|
The present disclosure provides biomarkers useful for determining the prognosis of conditions such as ovarian cancer. The presently disclosed subject matter provides angiogenic biomarkers and methods and compositions for predicting overall survival (os) in women with high-grade serious carcinomas (hgscs).
| Composition for targeting dendritic cells|
The present invention relates to a composition for targeting dendritic cells. In particular, the present invention relates to a composition comprising: a) one or more antigens; b) an anti-dc-sign immunoglobulin single variable domain; and c) a carrier which carries a) and b).
| Therapeutic combinations and methods of treating melanoma|
The invention provides therapeutic combinations of anti-etbr antibodies and map kinase inhibitors and methods of using the same to treat melanoma.. .
| Anomaly detector and environmental tester including the same|
A controlling section 41 receives determined temperature and humidity values, set temperature and humidity values, a heating electric power value, and a humidifying electric power value from a body controller 30. A comparison and determination section 46 compares the heating electric power value and the humidifying electric power value with respective predetermined reference electric power values, and when at least one of the heating electric power value or the humidifying electric power value is less than a corresponding one of the reference electric power values, the comparison and determination section 46 outputs an anomaly signal indicating that the cooling capacity of a refrigeration apparatus 22 has been reduced..
|Piracy prevention in digital rights management systems|
A method in a multimedia device (130) including obtaining protected content having a limited exercisable right associated therewith, obtaining an extension of the limited exercisable right when a condition is satisfied, for example, when the device enters a drm system different than the drm system from which the protected content originated, wherein the extension of the limited exercisable right is obtained from an entity other than the multimedia device, for example, from an anomaly detector.. .
|Method for vehicle intrusion detection with mobile router|
A method of operating a mobile router installed in a vehicle is provided. The vehicle comprises a vehicle network bus coupled to a plurality of electronic control units.
|Crc counter normalization|
The ability to accurately and efficiently calculate and report communication errors is becoming more important than ever in today's communications environment. More specifically calculating and reporting crc anomalies in a consistent manner across a plurality of communications connections in a network is crucial to accurate error reporting.
|Multipath data streaming over multiple wireless networks|
Embodiments described herein relate to real-time streaming of large quantities of time critical data over multiple distinct networks from a wireless communications device. More specifically, embodiments described herein may address challenges and problems of maintaining consistent data reception quality when faced with the anomalies of a moving sender that is sending data using a relatively unstable radio frequency (rf) method.
Nodes of a database service may receive a read request to perform a read of a record stored by the database service and a transaction request to perform a transaction to the record. First and second indications of time may be associated with the read and transaction, respectively.
|Detecting occurrence of abnormality|
A method, apparatus and computer program for detecting occurrence of an anomaly. The method can exclude arbitrariness and objectively judge whether a variation of a physical quantity to be detected is abnormal or not even when an external environment is fluctuating.
|Tyrosine, serine and threonine phosphorylation sites|
The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including aqua peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.. .
|Solution based polymer nanofiller-composites synthesis|
A solution based polymer nanofiller composite processing method to improve mechanical, electrical, thermal and/or chemical properties. The solution based synthesis method may include the steps of surface functionalizing carbon nanomaterials and dissolving a polymer in a solvent.
|Molecular signatures of invasive cancer subpopulations|
Carcinomas typically invade as a cohesive multicellular unit, a process termed collective invasion. It remains unclear how different subpopulations of cancer cells contribute to this process.
|Compositions and methods for screening and treatment of sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss)|
Compositions and methods for treatment of sturge-weber syndrome, klippel-trenaunay-weber syndrome, port-wine stains and related neurocutaneous disorders are provided. Cell lines having the somatic mutation gnaq p.arg183gln amino acid substitution, which was found to be the cause of port-wine stains (prevalence 1 in 300) and sturge-weber syndrome are also provided.
|Polypeptides targeting glycosylated muc2 proteins, methods of synthesis, their nucleic acids and uses thereof|
The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence p1(xa)p3(xb)p5(xc)p6(xd)p7 (seq id no: 1), presenting specific patterns. The polypeptides of the invention target glycosylated muc2 proteins.
|Therapeutic agent for cancer, and method for determining prognosis of cancer|
Disclosed are a novel therapeutic agent for cancer such as esophageal squamous cell carcinoma, a method for predicting the prognosis of cancer, and a method for detecting, or predicting the prognosis of, cancer such as esophageal squamous cell carcinoma using a sample that can be collected less invasively. The therapeutic agent for cancer comprises as an effective component an antibody that undergoes antigen-antibody reaction with fgfrl1 to suppress the growth of cancer cells, or an antigen-binding fragment thereof.
|Diagnostic image change highlighter|
Systems and methods are disclosed which enable more accurate examination of industrial diagnostic images, for example x-ray, ultrasound and terahertz camera images. The systems and methods highlight anomalies that have changed between the collection times of two or more diagnostic images, and can also provide objective scoring of the degree of change..
|Optimizing intermediate representation of script code for fast path execution|
Disclosed here are methods, systems, paradigms and structures for optimizing intermediate representation (ir) of a script code for fast path execution. A fast path is typically a path that handles most commonly occurring tasks more efficiently than less commonly occurring ones which are handled by slow paths.
|Method to identify multivariate anomalies by computing similarity and dissimilarity between entities and considering their spatial interdependency|
A method is presented for identifying anomalies based on the dissimilarity and similarity between multivariate samples. A step like procedure applies dissimilarity- and similarity computation in a sequenced fashion that considers variable variance, variable correlation and variable distribution pattern of the samples.
|Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases|
The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-hete synthesizing enzyme inhibitor or a 20-hete antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (adpkd), autosomal recessive polycystic kidney disease (arpkd), arpkd associated congenital hepatic fibrosis, arpkd associated caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-hete synthesizing enzyme inhibitor or a 20-hete antagonist to the mammal in an amount sufficient to prevent or treat the disease..
|Compositions comprising phytoestrogens receptor beta agonists and dietary fibers for chemopreventive treatment of sporadic adenomatous polyposis|
It is herein discloses compositions comprising a blend of dietary phytoestrogens receptor β agonists and dietary fibers for prevention and treatment of sporadic adenomatous polyposis. The aforementioned compositions proved to be effect in a clinical trial enrolling patients prone to polyp recurrence and at intermediate risk for colorectal cancer (crc) development..
|Detection of gene duplications|
Methods of detecting a candidate genetic anomaly such as a candidate duplication in a genome are disclosed. The methods comprise quantifying fluorogenic assays for alleles of a genetic locus from a plurality of individual genomes, identifying ranges of fluorescent intensities indicative of individual genomes homozygous for a first allele, homozygous for a second allele, or heterozygous for both alleles, and identifying individual genomes in which the fluorescence intensities are outside the range of intensities indicative of homozygosity or heterozygosity for the genetic locus..
|Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma|
Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described. An exemplary method for diagnosing head and neck squamous cell carcinoma (hnscc) in a subject may comprise assaying a saliva sample from the subject for the presence of total protein, solcd44, and hpv, and using the combination of total protein, hpv, and cd44 levels in a multivariate analysis to determine a combined score, whereby an increase in score above a cut-off point distinguishes subjects with hnscc, or an elevated risk of future occurrence thereof, from subjects without hnscc or at low risk of future occurrence thereof..
|Micronized tanaproget, compositions, and methods of preparing the same|
The present invention provides compositions, desirably pharmaceutical compositions, containing micronized tanaproget. The compositions can also contain microcrystalline cellulose, croscarmellose sodium, anhydrous lactose, magnesium stearate, micronized edetate calcium disodium hydrous, and micronized sodium thiosulfate pentahydrate.
|Detecting timing anomalies|
Disclosed herein are system, method, and computer program product embodiments for adapting to malware activity on a compromised computer system. An embodiment operates by detecting an active adversary operating malware on a compromised system.
|Method and system to dynamically detect traffic anomalies in a network|
Methods implemented in a network are disclosed for dynamically distributing tasks of traffic anomaly monitoring and detecting traffic anomalies. The method starts collecting traffic statistics of large blocks of traffic flows as traffic aggregates.
|Detecting anomalies in work practice data by combining multiple domains of information|
One embodiment of the present invention provides a system for multi-domain clustering. During operation, the system collects domain data for at least two domains associated with users, wherein a domain is a source of data describing observable activities of a user.
|Anomaly detection in chain-of-custody information|
A method includes receiving first vehicle log data related to modification of a first software part at a first vehicle. The method also includes receiving first ground log data of a first ground system.
|Methods and systems of classifying spam url|
A method of operation of a url spam detection system includes: identifying a feature dimension of a user action on a social networking system to detect anomalies; extracting url chunks from a content associated with the user action; aggregating a non-content feature of the user action along the feature dimension into a url distribution store to produce a feature distribution for each of the url chunks; determining whether the feature distribution of a particular url chunk within the url chunks exceeds an expectation threshold for the feature dimension; and classifying the particular url chunk as an illegitimate url when the feature distribution exceeds the expectation threshold to restrict access to a particular url chunk on a social networking system.. .
|System and method for analyzing voltage breakdown in electrostatic chucks|
A system, instructions and a method of determining when an impending failure is likely to occur absent corrective action are disclosed. The system samples the output of a power supply which powers an electrostatic chuck, and determines when that output is outside acceptable limits.
|Methods and apparatus for detecting and localizing partial conductor failures of implantable device leads|
Method and apparatus for diagnosis of conductor anomalies, such as partial conductor failures, in an implantable lead for an implantable medical device are disclosed. In various embodiments, small changes in the lead impedance are identified by the use of a small circuit element that is incorporated as part of the distal end of the implantable lead.
|Remote health monitoring system|
A data collection system collects and stores physiological data from an ambulatory patient at a high resolution and/or a high data rate (“more detailed data”) and sends a low-resolution and/or downsampled version of the data (“less detailed data”) to a remote server via a wireless network. The server automatically analyzes the less detailed data to detect an anomaly, such as an arrhythmia.
|Methods of treating dermatological disorders and inducing interferon biosynthesis with shorter durations of imiquimod therapy|
Pharmaceutical formulations and methods for the topical and/or transdermal delivery of imiquimod, including creams, ointments and pressure-sensitive adhesive compositions to treat dermatological disorders, namely, viral infections, such as type i or type ii herpes simplex infections and genital and perianal warts, actinic deratosis and superficial basal cell carcinoma, and to induce interferon biosynthesis to achieve an antiviral effect, with shorter durations of therapy, than currently approved for imiquimod by the food & drug administration (“fda”).. .
|Differential identification of pancreatic cysts|
More than 2% of adults harbor a pancreatic cyst, a subset of which progress to invasive lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of the pancreas, we determined the exomic sequences of dna from the neoplastic epithelium of eight surgically resected cysts of each of the major neoplastic cyst types: serous cystadenomas (scas), intraductal papillary mucinous neoplasms (ipmns), mucinous cystic neoplasms (mcns) and solid pseudo-papillary neoplasms (spns).
|Natural and synthetic compounds for treating cancer and other diseases|
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
|Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof|
The invention relates to a unique formulated pharmaceutical composition and a novel treatment method of intratumoral injection. The pharmaceutical composition of the invention is the saturated ionic solution of sodium ions and calcium ions (the “medicinal ion bomb”).
|Heat generating nanomaterials|
The present invention relates to a heat-generating composition, comprising a hetero-structure nanomaterial which comprises (a) a first material comprising at least one component selected from the group consisting of a metal, a metal chalcogen, a metal pnicogen, an alloy and a multi-component hybrid structure thereof; and (b) a second material comprising at least one component selected from the group consisting of metal, metal chalcogen, metal pnicogen, alloy and the multi-component hybrid structure thereof; wherein the first material is enclosed in the second material; wherein at least one of the first material and the second material comprise a magnetic material. The specific loss power of the present nanomaterial is much higher than that of conventional nanomaterials (e.g., 40-fold higher than commercially accessible feridex) and may be controlled by changing compositions or ratios of the first material and/or the second material.
|Ige anti-hmw-maa antibody|
In one aspect, there is provided an antibody or a functional fragment thereof, wherein the antibody or functional fragment thereof is capable of binding specifically to high molecular weight melanoma associated antigen (hmw-maa), and binding to an fcε receptor.. .
|Analysis and targeting of ror2 in cancer|
Ror2 is provided as a therapeutic target and prognostic marker for cancers, which include without limitation specific carcinomas and sarcomas. This invention also provides for the use of conjugates comprising an antibody that recognizes and binds ror2, and a cytotoxic agent.
|Methods and agents for the diagnosis and treatment of hepatocellular carcinoma|
The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists of plvap proteins, such as antibodies that specifically bind plvap proteins, as well as compositions and kits comprising antagonists of plvap proteins.
|Materials and methods useful to induce cell death via methuosis|
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer.
|Drone for collecting images and system for categorizing image data|
A data collection system provides a first computer media for collecting image data, a second computer media for analyzing the image data and locating anomalies in the image data, a third computer media for linking particular image data to address data of the property where the anomaly is present and a fourth computer media for generating a list of pertinent properties having similar anomalies by address. The image data collected by an unmanned aerial vehicle or drone..
|Integrin-blocking polypeptides and uses thereof|
A series of integrin blockers that present strong angiogenesis inhibiting performance, high integrin affinity and integrin-bonding capacity is provided. This series of integrin blockers can be adopted in treatment of solid tumors and rheumatoid arthritis.