 Patent Application Title |
Patent App Num. |
Date |
| Diamond-like carbon coated nanoprobes | 20110107473 | 20110505 |
| Diamond-like carbon (DLC) coated nanoprobes and methods for fabricating such nanoprobes are provided. The nanoprobes provide hard, wear-resistant, low friction probes for use in such applications as atomic force microscopy, nanomachining, nanotribology, metrology and nanolithography. The diamond-like carbon coatings include a carbon implantation layer which increases adhesion of a deposited DLC layer to an underlying nanoprobe tip.
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| Skin cancer associated micrornas | 20110107440 | 20110505 |
| This invention relates to the finding that skin cancers, such as squamous cell carcinoma and basal cell carcinoma, are characterized by changes in the expression of specific microRNA molecules (miRNAs). These miRNAs may therefore be useful as biomarkers for skin cancers as well as therapeutic targets. Methods of diagnosis and treatment of skin cancers are provided, as well as methods of screening for therapeutic compounds.
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| Detecting anomalies in access control lists | 20110107418 | 20110505 |
| An access control anomaly detection system and method to detect potential anomalies in access control permissions and report those potential anomalies in real time to an administrator for possible action. Embodiments of the system and method input access control lists and semantic groups (or any dataset having binary matrices) to perform automated anomaly detection. This input is processed in three broad phases. First, policy statements are extracted from the access control lists. Next, object-level anomaly detection is performed using thresholds by categorizing outliers in the policies discovered in the first phase as potential anomalies. This object-level anomaly detection can yield object-level security anomalies and object-level accessibility anomalies. Group-level anomaly detection is performed in the third phase by using semantic groups and user sets extracted in first... |
| Reagents for the detection of protein phosphorylation in carcinoma signaling pathways | 20110105732 | 20110505 |
| The invention discloses 214 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeleton proteins, GTP Signaling proteins, Kinases, Metabolism proteins, Phosphatases/Phospho-diesterases/Proteases, Receptor proteins, RNA Processing proteins, Transcription proteins, Translation proteins, Transporter proteins, and Ubitquitin proteins, as well as other protein types.
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| Method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker | 20110105723 | 20110505 |
| A method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker are disclosed. Firstly, a specimen is obtained from a testee. Next, the specimen is tested for its MIP-3α expression level. Then, the MIP-3α expression level of the specimen is compared with that of a control. Finally, the malignancy of nasopharyngeal carcinoma is determined according to a relative MIP-3α expression level between the specimen and the control.
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| Methods for diagnosing and treating squamous cell carcinoma utilizing mirna-205 and inhibitors thereof | 20110105585 | 20110505 |
| Disclosed are diagnostic and therapeutic methods related to squamous cell carcinoma. In particular, the diagnostic methods relate to detecting miRNA-205, thereby diagnosing an aggressive form of squamous cell carcinoma. The therapeutic methods relate to inhibiting the function of miRNA-205, thereby treating an aggressive form of squamous cell carcinoma.
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| Tyrosine, serine, and threonine phosphorylation sites | 20110104820 | 20110505 |
| The invention discloses 94 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies that specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
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| Screening method for inhibitors of cancer cell invasion and screening system thereof | 20110104741 | 20110505 |
| This invention relates to a screening method for an inhibitor to cancer cell invasion, comprising the steps of: (a) co-culturing cancer cells and a carcinoma-associated fibroblasts (CAFs) in a multi-chamber containing a upper-chamber, a lower-chamber and a porous filter separating the upper-chamber from the lower-chamber; in which each cancer cells and CAFs is inoculated into the upper-chamber and the lower-chamber of the multi-chamber, and then a candidate is added to the upper-chamber; and (b) measuring the number of cancer cells passing the porous filter. According to the screening system and screening method using the same, the inhibitor to cancer cell invasion is able to be screened in a high-throughput manner.
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| Methods and compositions for diagnosing carcinomas | 20110104675 | 20110505 |
| The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular the invention provides a nucleic acid sequence encoding MRA and an MRA variant. The invention also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a mesothelin polypeptide with a molecule naturally occurring in soluble form in a sample from such a subject, and by hybridization screening using an MRA nucleotide sequence, as well as other related advantages.
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| Method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker | 20110104657 | 20110505 |
| A method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker are disclosed. Firstly, a specimen is obtained from a testee. Next, the specimen is tested for its MIP-3α expression level. Then, the MIP-3α expression level of the specimen is compared with that of a control. Finally, the malignancy of nasopharyngeal carcinoma is determined according to a relative MIP-3α expression level between the specimen and the control.
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| Medicament for treatment of tumors wherein hedgehog/smoothened signaling is employed for inhibition of apoptosis of the tumor cells | 20110104254 | 20110505 |
| This invention concerns the use of cyclopamine in vivo on basal cell carcinomas (BCC's) to achieve therapeutic effect by causing differentiation of the tumor cells and, at the same time, apoptotic death and removal of these tumor cells while preserving the normal tissue cells, including the undifferentiated cells of the normal epidermal basal layer and hair follicles. Causation of apoptosis by cyclopamine is by a non-genotoxic mechanism and thus unlike the radiation therapy and most of the currently used cancer chemotherapeutics which act by causing DNA-damage. These novel effects, previously unachieved by a cancer chemotherapeutic, make the use of cyclopamine highly desirable in cancer therapy, in the treatment of BCC's and other tumors that use the hedgehog/smoothened signal transduction pathway for proliferation and prevention of apoptosis.
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| Anti-apoptotic gene scc-s2 and diagnostic and therapeutic uses thereof | 20110104252 | 20110505 |
| A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous leukemia, lung, lymphoblastic leukemia, and colorectal adenocarcinoma cells.
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| Liver cancer drug | 20110104157 | 20110505 |
| A novel pharmaceutical composition for treating or preventing hepatocellular carcinoma and a method of treatment are provided. A pharmaceutical composition for treating or preventing liver cancer is obtained by combining a chemotherapeutic agent with an anti-glypican 3 antibody. Also disclosed is a pharmaceutical composition for treating or preventing liver cancer which comprises as an active ingredient an anti-glypican 3 antibody for use in combination with a chemotherapeutic agent, or which comprises as an active ingredient a chemotherapeutic agent for use in combination with an anti-glypican 3 antibody. Using the chemotherapeutic agent and the anti-glypican 3 antibody in combination yields better therapeutic effects than using the chemotherapeutic agent alone, and mitigates side effects that arise from liver cancer treatment with the chemotherapeutic agent.
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| T cell receptors and related materials and methods of use | 20110104129 | 20110505 |
| The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
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| Genetic alteration associated with pre-malignant cancer | 20110104065 | 20110505 |
| Described herein are progenitor cancer cells and cell lines isolated from human breast ductal carcinoma in situ (DCIS) lesions and the uses of these cells or cell lines in drug design, drug screening, and monitoring in vivo therapy. The DCIS malignant precursor cells or cell lines are epithelial in origin, are positive for markers of autophagy, show at least one genetic difference from normal cells of said fragment, form 3-D tube-like structures or ball aggregates, or are inhibited in formation of 3-D structures and migration by treatment with chloroquine. In one embodiment, there is a loss of heterozygosity (LOH) that is narrowly confined to a region of chromosome 6p (6p21.1-6p12.3) that contains the SUPT3H gene.
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| Anomaly detector for pipelines | 20110103189 | 20110505 |
| Apparatus for locating an object in a pipeline, comprising a transmitting station having means for transmitting in the pipeline acoustic emissions having a frequency in the range from 20 KHz to 200 KHz; a receiving station having a receiver capable of receiving the acoustic emissions transmitted by the transmitting station; one of the receiving station and the transmitting station being located at a known position on the pipeline and the other of the receiving station and the transmitting station being located on the object; and clock means to determine the time taken for the acoustic emissions to travel between the transmitting station and the receiving station.
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| Blue extended super continuum light source | 20110102882 | 20110505 |
| Phase match between red shifted Raman solitons generated by the pump pulse and energy shed by the pump pulse at all frequencies with a group velocity below the pump pulse group velocity will lead to the formation of Cherenkov radiation. The solitons or “light bullets” will seed Cherenkov radiation in the near infrared, visible or at UV wavelengths depending on the actual fibre parameters. This extends the generated super continuum light beyond the four wave mixing limit usually experienced when applying picoseconds or nanoseconds pump pulses.
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| Diagnostic method for an internal combustion engine exhaust gas system that includes a particle filter | 20110100094 | 20110505 |
| In a method for the diagnostics of an internal combustion engine exhaust gas system that includes a particle filter, first and second sets of value vectors are determined, each including associated values for absolute pressure upstream and downstream of the particle filter, a differential pressure determined from the values of the absolute pressure, an exhaust gas volume flow through the particle filter, and a temperature of the exhaust gas volume flow. After a temperature-standardization of the pressure values, characteristics for dependence of the pressure values are generated from temperature-standardized values of the first set of value vectors and possibly stored as reference characteristics. By comparing temperature-standardized values for the absolute pressure on the inlet and outlet sides of the particle filter and the differential pressure of... |
| Mig-6 knockout mice and elucidation of association of mig-6 with early onset degenerative joint disease and role as a tumor suppressor | 20110099644 | 20110428 |
| The molecular mechanism underlying degenerative joint disease, also known as osteoarthritis (OA), is not fully understood. Disruption of mitogen inducible gene 6 (Mig-6) in mice by homologous recombination (KO mice) led to early onset OA as revealed by simultaneous enlargement and deformity of multiple joints, degradation of articular cartilage and the development of bony outgrowths or osteophytes within the joint space. The latter appeared to be derived from proliferation of mesenchymal progenitor cells followed by differentiation into chondrocytes. Because of the striking similarity to human OA, Mig-6 KO mice are a useful animal model for studying the mechanism of this disease and for testing new drugs or therapies for treating OA. These KO mice also developed epithelial hyperplasia, adenoma, and adenocarcinoma in organs such as lung,... |
| System and method of containing computer worms | 20110099633 | 20110428 |
| A computer worm containment system comprises a detection system and a blocking system. The detection system orchestrates a sequence of network activities in a decoy computer network and monitors that network to identify anomalous behavior and determine whether the anomalous behavior is caused by a computer worm. The detection system can then determine an identifier of the computer worm based on the anomalous behavior. The detection system can also generate a recovery script for disabling the computer worm or repairing damage caused by the computer worm. The blocking system is configured to use the computer worm identifier to protect another computer network. The blocking system can also use the recovery script to disable a computer worm within the other network and to repair damage caused to... |
| Methods and apparatus for secure, portable, wireless and multi-hop data networking | 20110099611 | 20110428 |
| A mobile network solution provides secure and portable wireless networking service to mobile users with devices equipped with wireless network interfaces. The Secure Nomadic Wireless Network, or SNOWNET, follows a hierarchical approach. Special SNOWNET nodes are deployed in the area where networking service is needed and form a backbone network. At the same time, SNOWNET nodes provide local access service to regular mobile clients. SNOWNET provides security through authentication of the nodes and clients, as well as through encryption of the data.
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| Automatic baselining of metrics for application performance management | 20110098973 | 20110428 |
| An application monitoring system monitors one or more applications to generate and report application performance data for transactions. Actual performance data for one or more metrics is compared with a baseline metric value(s) to detect anomalous transactions or components thereof. Automatic baselining for a selected metric is provided using variability based on a distribution range and arithmetic mean of actual performance data to determine an appropriate sensitivity for boundaries between comparison levels. A user-defined sensitivity parameter allows adjustment of baselines to increase or decrease comparison sensitivity for a selected metric. The system identifies anomalies in transactions, components of transaction based on a comparison of actual performance data with the automatically determined baseline for a corresponding metric. The system reports performance data and other transactional data for... |
| program product to screen for longitudinal-seam anomalies | 20110098941 | 20110428 |
| Embodiments of the present invention provide systems, program product and methods to detect crack-like features in pipeline welds using magnetic flux leakage data and pattern recognition. A screening process, for example, does not affect or change how survey data is recorded in survey tools; only how it is analyzed after the survey data is completed. Embodiments of the present invention can be used to screen for very narrow axial anomalies in the pipeline welds, and may also be used to predict the length of such anomalies. Embodiments of the present invention also produce a listing of the anomalies based on their relative signal characteristics.
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| Device and method of using superparamagnetic nanoparticles in treatment and removal of cells | 20110098623 | 20110428 |
| Methods and devices for selectively removing from a subject a target cell, pathogen, or virus expressing a binding partner on its surface are presented. In one embodiment, the device contains an excorporeal circuit, which includes, at least, a magnetic filter comprising a magnet and a removable, magnetizable substrate capable of capturing magnetic nanomaterials; and a pump in fluid communication with the magnetic filter, wherein the pump moves fluid through the excorporeal circuit. The magnet is capable of generating a magnetic field sufficient to capture magnetic nanomaterials in the magnetic field. In a preferred embodiment, the target cells are cancer cells and/or cells infected with pathogenic agents. The devices may be designed for extracorporeal or in vivo uses. Functionalized superparamagnetic nanoparticles are either mixed ex vivo with... |
| In vitro methods for detecting renal cancer | 20110098191 | 20110428 |
| The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.
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| Method of diagnosing neoplasms - ii | 20110098189 | 20110428 |
| The present invention relates generally to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The DNA or the expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect... |
| Monoclonal antibody binds antigen associated with human tumors | 20110097747 | 20110428 |
| The present invention is concerned with a novel antigen associated with human tumors, including carcinomas of the colon, pancreas, and lung, as well as novel monoclonal antibodies which binds strongly to said antigen. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use both in diagnostic methods such as the detection of malignant cells associated with tumors and in therapeutic methods for treatment of humans with tumors. The novel antigen disclosed is a 60,000 Dalton glycoprotein found on the cell surface of human tumor cells.
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| Plasma biomarker tool for the diagnosis of liver cancer comprising liver carboxylesterase 1 and liver cancer screening method | 20110097738 | 20110428 |
| The present invention relates to a plasma biomarker for diagnosing hepatocellular carcinoma (HCC), in particular to the discovery of a protein in plasma using 2-D fluorescence differential gel electrophoresis (2-D DIGE), immunoprecipitation and Nano-liquid chromatography mass spectrometry (Nano-LC-MS/MS) system that was unknown on the basis of conventional techniques. By demonstrating the presence of liver carboxylesterase 1 (hCE1) in human plasma and confirming that its secretion level is higher in patients with HCC than in healthy volunteers, this invention may be used as a screening method to diagnose HCC at an early stage.
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| Dna markers for management of cancer | 20110097727 | 20110428 |
| A method is provided for assessing allelic losses and hypermethylation of genes in CpG tumor promotor region on specific chromosomal regions in cancer patients, including melanoma, neuroblastoma breast, colorectal, and prostate cancer patients. The method relies on the evidence that free DNA and hypermethylation of genes in CpG tumor promotor region may be identified in the bone marrow, serum, plasma, and tumor tissue samples of cancer patients. Methods of melanoma, neuroblastoma, colorectal cancer, breast cancer and prostate cancer detection, staging, and prognosis are also provided.
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| Gene prognosis predictor signature for colorectal carcinoma | 20110097423 | 20110428 |
| The present invention is drawn to methods of assessing colorectal cancer prognosis by examining the expression of particular genes disregulated in this disease state. Subjects exhibiting disregulation in one or more of these genes will have a higher risk of cancer recurrence and death.
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| Patient data management apparatus for comparing patient data with ailment archetypes to determine correlation with established ailment biomarkers | 20110015942 | 20110120 |
| The Medical Diagnostic Apparatus implements a physician-operated medical data analysis system for assisting a physician in identifying ailments and conditions which correlate to anomalies identified in a set of patient medical data relating to an identified patient. This system includes a plurality of biomarkers which relate to interpreting patient medical data and possible ailments associated with patient medical data. A data characterization module displays biomarkers selected by a physician and a set of patient medical data, collected from and about an identified patient, to compare the set of patient medical data with biomarkers of known ailments to enable the physician to identify an ailment representative of the patient medical data.
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| Apparatus and method for detecting components of mixed gas | 20110015874 | 20110120 |
| For this purpose, the present invention provides an apparatus for detecting components of a mixed gas, in which a plurality of optical fiber sensors such as D-shaped optical fiber Bragg grating sensors, long period grating sensors, and Fabry-Perot optical fiber sensors in which nanomaterials are patterned or coated on an side or end of each optical fiber are used. In the case of the D-shaped optical fiber sensor, nanomaterials such as carbon nanotubes (CNT), zinc oxide (ZnO), titanium dioxide (TiO2), and tin dioxide (SnO2) are coated on a flat surface of a core region, thus forming an optical fiber sensor array including a plurality of optical fiber sensors formed with different nanomaterials such that the cross-section of the D-shaped optical fiber senor is oriented outwardly to... |
| Functionalized carbon nanostructures which are soluble in hydrocarbons and method for preparation | 20110015423 | 20110120 |
| Carbon nanomaterials functionalized on their surface with ester or amide functionality are made using a technique involving multiple space apart in time or dropwise additions of reactants to the carbon nanomaterials, and are soluble in hydrocarbon liquids.
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| Reduced friction lubricating oils containing functionalized carbon nanomaterials | 20110015106 | 20110120 |
| Lubricating oil of reduced friction comprise lubricating oil base stock and dissolved therein carbon nanomaterials functionalized on their surface with ester or amide functionality and made using a technique involving multiple space apart in time or dropwise additions of reactants to the carbon nanomaterials.
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| Method for diagnosing non-small cell lung cancers by trna-dihydrouridine synthase activity of urlc8 | 20110014615 | 20110120 |
| The present invention features a method for determining t-RNA dihydrouridine-synthase activity of a polypeptide and screening for modulators of t-RNA dihydrouridine-synthase activity. The present invention further provides methods or pharmaceutical compositions for preventing and/or treating non-small cell lung cancer (NSCLC) using such modulators. Furthermore, the present invention provides methods for diagnosing non-small cell lung cancer (NSCLC) using the t-RNA dihydrouridine-synthase activity of IMS-E21 (URLC8) protein as an index. The present invention further provides methods for predicting and prognosing lung squamous-cell carcinoma (SCC).
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| Diagnostic composition for hepatocellular carcinoma, a diagnostic kit comprising it and diagnostic methods of hepatocellular carcinoma | 20110014602 | 20110120 |
| In the present invention, it is confirmed that cystatin B (cystatin B, CSTB) can be used as a diagnostic marker for hepatocellular carcinoma. Accordingly, the invention relates to a method for early diagnosing hepatocellular carcinoma using the cystatin B as a diagnostic marker for hepatocellular carcinoma, a method for determining the progression or prognosis of hepatocellular carcinoma according to the CSTB expression level, and a method for applying to the prevention or treatment of hepatocellular carcinoma by adjusting the cystatin B expression.
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| Mcam modulation and uses thereof | 20110014183 | 20110120 |
| Methods, uses, agents and compositions useful for the diagnosis, prevention and/or treatment of inflammatory conditions, such as neuroinflammatory conditions such as multiple sclerosis, and for the identification and selection of inflammatory cytokine-secreting T cell or a precursor thereof, based on the expression and/or modulation of melanoma cell adhesion molecule (MCAM) are disclosed.
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| Methods for manipulating phagocytosis mediated by cd47 | 20110014119 | 20110120 |
| Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
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| Apparatus for skin imaging, system for skin analysis | 20110013006 | 20110120 |
| The invention relates to an apparatus for skin imaging, a system for skin analysis and a method for skin analysis, using a combination of near-field and far-field skin images under different angles of illumination. The apparatus provides a tool that may be employed for rapid screening of the skin for lesions that may be indicative of skin diseases, in particular skin cancers such as melanoma.
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| Dynamic generation of images to facilitate information visualization | 20110012917 | 20110120 |
| Approaches for generating a digital image that facilitates data analysis. An application may arrange values of one or more data sets into a table based on a selected set of columns. The application may apply one or more formulas to each cell to generate a second table that has a single value in each cell. The application maps, for each cell of the second table, the value stored therein to an attribute (such as a color). The application may generate a digital image by determining a color for each pixel of the digital image based on how the cells are mapped to colors. The digital image enables data analysis, such as the identification of trends, patterns, and/or anomalies, on any number of data sets in an... |
| Electrodynamic arrays having nanomaterial electrodes | 20110011629 | 20110120 |
| An electrodynamic array of conductive nanomaterial electrodes and a method of making such an electrodynamic array. In one embodiment, a liquid solution containing nanomaterials is deposited as an array of conductive electrodes on a substrate, including rigid or flexible substrates such as fabrics, and opaque or transparent substrates. The nanomaterial electrodes may also be grown in situ. The nanomaterials may include carbon nanomaterials, other organic or inorganic nanomaterials or mixtures.
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| Products and their use for the diagnosis, prevention and/or care of human and/or animal pathologies characterised by the anomalous deposition of b-amyloid and/or amyloid-like substance in human and/or animal organs and tissues, and screening method for de | 20110010785 | 20110113 |
| The patent refers to a screening method carried out on biological material isolated from human and/or animal organisms for determining the risk of human and/or animal pathologies expressing an anomalous deposition of β-amyloid and/or amyloid-like substance in human and/or animal organs and tissues, based on the investigation of the punctiform mutation Ala>Val in position 2 of the β-protein (corresponding to the Ala673Val mutation precursor of the β-protein containing 770 amino acids) in homozygosis or in heterozygosis. The patent provides for the possibility of: (1) creating unicellular or multicellular transgenic organisms expressing the Ala673Val mutation; (2) synthesising or producing peptides with such mutation and/or their derivatives and/or nucleic acids containing the same mutation; (3) using such products for studying the pathogenesis of the pathologies characterised by anomalous... |
| Apparatus state detector, method for detecting apparatus state, apparatus state detection server and apparatus state detection system; living persons' anomaly detector, living persons' anomaly detection system and method for detecting living persons' anom | 20110010106 | 20110113 |
| An apparatus state detector and its associates are provided to save time and effort for learning combinations of operation states of all apparatuses at home and commit fewer estimation errors even when an unknown apparatus starts operating. The apparatus state detector includes measuring means 110 that measures a physical quantity of an environment in which an apparatus is placed, feature-quantity calculation means 120 that calculates a feature quantity of the measured value measured by the measuring means 110, storage means 140 that stores in advance the feature quantity of each apparatus and an apparatus state associated with the feature quantity in a reference-apparatus entry dictionary 200, and apparatus-state detection means 130 that searches the reference-apparatus entry dictionary 200 for a feature quantity by using a feature... |
| Rnai probes targeting cancer-related proteins | 20110009472 | 20110113 |
| RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and -5 simultaneously, Mitf, and B-raf. The invention further provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual,... |
| Methods and reagents for the early detection of melanoma | 20110009288 | 20110113 |
| An assay for identifying early stage malignant melanocyte in biopsy tissues is provided by determining whether differential expression of a particular gene indicative of melanoma exceed a cut-off value.
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| Biomarkers for the diagnosis and treatment of pancreatic cancer | 20110008914 | 20110113 |
| Compositions and methods which indicate an increased risk for pancreatic carcinoma are disclosed.
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| Lipid insertion for antigen capture and presentation and use as a sensor platform | 20110008798 | 20110113 |
| It has been found that moieties containing a lipophilic domain, e.g., lipophilic pathogen activated molecular patterns (PAMPs), insert into the lipid bilayer on a cell membrane to facilitate antigen recognition by the innate immune response receptors. This changes the basic understanding of antigen recognition by the innate immune system. A sensor platform for the ultra-sensitive and specific detection of moieties containing such a lipophilic domain, e.g., PAMPs, that are associated with a disease, has now been developed. To date, this approach has been validated with Lipoarabinomannan (LAM) from Mycobacterium tuberculosis and lipopolysacharide (LPS), associated with gram-negative bacteria. This approach may be extendable to all lipophilic targets associated with pathogens and thus, is the basis of a very simple and specific sensing platform. In addition, novel applications... |
| Compositions and methods for immortalizing cells and screening for anti-cancer agents | 20110008302 | 20110113 |
| An embodiment of the invention provides methods and compositions for immortalizing cells, and in another embodiment for reversing immortalization of cells. Methods for screening for anti-cancer agents by identifying compounds that bind to and inhibit activity of an Ndy protein are also provided. Novel cancer diagnostic and prognostic methods using Ndy1, Ezh2 and miR-101 are shown with samples of tissue or cell lines from cancers of lung, colon, ovary, bladder and transitional cell carcinoma.
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| System and method for generating nanoparticles | 20110008246 | 20110113 |
| Systems and methods for generating nanomaterial are described wherein a reaction, for example, oxidation, for generating nanomaterial occurs in an open reaction zone which is external to the nanoparticle generator. The systems and methods minimize damage to the hot wall reactors evident in conventional systems and methods used to generate nanomaterial.
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| Multipath video streaming over a wireless network | 20110007693 | 20110113 |
| The method and system as disclosed relates to streaming of large quantities of time critical data over multiple distinct channels from a wireless communications device to a central receiver. More specifically the disclosure deals with the challenges and problems of maintaining consistent data reception quality when faced with the anomalies of a moving sender that is sending data using a relatively unstable radio frequency (RF) method. This is achieved by converting single source data into multiple data streams, placing them in transport buffers and storing them for forwarding. A plurality of radio frequency modules provide wireless connectivity to a plurality of wireless network. Links are maintained to provide feedback on network connections to allow for the transfer of data from one network to another and to... |
| Display panel and touch-responsive display assembly | 20110007012 | 20110113 |
| A touch-responsive display assembly includes a touch panel. The touch panel includes: an anode, a cathode disposed over the anode, and an organic layered structure disposed between the anode and the cathode and including an organic electroluminescent layer that is emissive when a voltage is applied across the anode and the cathode. At least one of the anode and the cathode is made of a flexible film of a conductive nanomaterial that contains interconnected nanounits.
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| Use of an ozone/oxygen mixture as primary anticancer therapy through intraperitoneal insufflation | 20110006261 | 20110113 |
| Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts anti-tumorous effects in vivo. Therapeutic insufflation of medical ozone/oxygen (O3/O2) gas mixture into the peritoneum (O3/O2-pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O2) resulted in a survival rate of 3/13 animals accompanied by... |
| Method for making a conductive film exhibiting electric anisotropy, conductive plate and method for making the same | 20110005816 | 20110113 |
| A method for making a conductive film exhibiting electric anisotropy comprises forming a nanomaterial on a substrate, the nanomaterial having a cluster of interconnected nanounits, each of which being substantially transverse to the substrate and having one end bonded to the substrate. The method further includes stretching the nanounits along a first direction to remove the nanomaterial from the substrate so as to form a conductive film having strings of interconnected nanounits, where the nanounits of the strings substantially extend in the first direction. A conductive plate and a method for making the same is also disclosed, where the method further comprises attaching the conductive film to a second substrate.
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| Method for manufacturing animal model for researching pulmonary tumor and use thereof | 20110004950 | 20110106 |
| The present invention is a method for manufacturing an animal model for researching a pulmonary tumor and a use thereof. A transgenic non-human animal of the present invention is prepared by embryonic gene microinjection and possesses a tissue-specific expression of vascular endothelial growth factor A165 (VEGF-A165) in lung. Through the expression of vascular endothelial growth factor A165, the lung cells in the transgenic non-human animal of the present invention have inflammatory, vascularogenesis and angiogenesis responses or induce lung tumors. Thus, the non-human animal of the present invention can serve as an animal model for analyzing the regulation and the anti-tumor drugs screening of pulmonary adenocarcinoma.
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| Anomaly notification control in disk array | 20110004786 | 20110106 |
| In a storage device incorporating a plurality of kinds of disk drives with different interfaces, the controller performs sparing on a disk drive, whose errors that occur during accesses exceed a predetermined number, by swapping it with a spare disk drive that is prepared beforehand.
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| Role based identity tracker | 20110004580 | 20110106 |
| Particular embodiments use roles to determine anomalies in a user's behavior. Different roles may be defined for a business. For example, users that have similar job responsibilities are grouped in a role. Behavior information is then monitored for the plurality of users in the role. This may include transactions or other actions taken by the user. Over time, a profile can be generated for the user based on the monitored behavior. This profile learns the user's behavior. Information for the user's behavior may then be compared to other users' profiles in the same role to determine anomalies in the user's behavior over time. For example, when differences in activities occur for a user as compared to other users with the same role, a message may be... |
| Methods and nucleic acids for analyses of cell proliferative disorders | 20110003292 | 20110106 |
| The invention provides methods, nucleic acids and kits for detecting lung carcinoma. The invention discloses genomic (FOXL2, ONECUT1, TFAP2E, EN2-2, EN2-3, SHOX2-2 and BARHL2) sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
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| Aberrantly methylated genes in pancreatic cancer | 20110003284 | 20110106 |
| The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having the pancreatic carcinoma, thereby detecting pancreatic carcinoma in the subject.
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| Fluorination of multi-layered carbon nanomaterials | 20110003149 | 20110106 |
| The invention provides fluorinated multi-layered carbon nanomaterials and methods for their production. In one aspect of the invention, the carbon nanomaterials are partially fluorinated and retain some unreacted carbon. The invention also provides electrodes and electrochemical devices incorporating the fluorinated carbon nanomaterials of the invention. In one aspect of the invention, the electrochemical has a first electrode including the at least partially fluorinated carbon materials of the invention and a second electrode including a source of lithium ions
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| Fabrication method of nanomaterials by using polymeric nanoporous templates | 20110003069 | 20110106 |
| A fabrication method of a nanomaterial by using a polymeric nanoporous template is disclosed. First, a block copolymer bulk is made from a block copolymer polymerized from decomposable and undecomposable monomers. By removing the decomposable portion of the block copolymer bulk, the polymeric nanoporous template with a plurality of holes is obtained, and these holes have nanostructures with regular arrangement. By exploiting a nanoreactor concept, a sol-gel process or an electrochemical synthesis, for example, is then carried out within the template such that the holes are filled with various filler materials, such as ceramics, metals and polymers, so as to prepare a nanocomposite material having the nanostructure. After removing the polymeric nanoporous template, the nanomaterial with the nanostructure is manufactured.
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| Earthquake prediction information provision system, portable terminal, earthquake prediction information provision method, and recording medium | 20090326821 | 20091231 |
| A detection of an anomaly of geomagnetism and a collection of data are performed by using portable telephones. Direction variations measured by geomagnetic sensors mounted to the portable telephones are collected via data transmission lines for portable telephones, and the variations are observed for each area. Earthquake occurrence warning information is transmitted to a portable terminal of a collaborator for geomagnetism information provision in an area in which a number of occurrences of the variations is significantly large.
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| Non real time traffic system for a navigator | 20090326805 | 20091231 |
| A system for improving the operation of a GPS based navigator. Statistical and/or time of day information is used to select the best route between a current location and a desired location. The statistical information may take into account anomalies, and a user can select the amount of risk they which take. The system can be updated with more updated information. In addition, the selection of the desired location can be carried out by downloading information from a PDA.
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| Novel actives against prostate carcinoma | 20090326056 | 20091231 |
| The present invention relates to the use of a composition comprising lycopene and genistein in the prevention and coadjuvant treatment of prostate carcinoma. The present invention is also directed to the use of a composition comprising lycopene and epigallocatechin gallate in the prevention and coadjuvant treatment of prostate carcinoma. More specifically, the present invention relates to the use of one of these compositions in the primary prevention (i.e., the prophylactic supplementation of healthy subjects) of the onset of prostate carcinoma, in the coadjuvant treatment (i.e. the supplementation accompanying a running therapy of prostate carcinoma) and in the secondary prevention (i.e., the supplementation after a successful therapy for the prevention of relapse) of prostate carcinoma. Furthermore, the present invention is also directed to the reduction/decrease of the... |
| Imidazo[4, 5-b]pyridin-2-one and oxazolo[4, 5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds | 20090325945 | 20091231 |
| The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5 b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc., and more particularly to compounds of the formulae: wherein: J is independently —O— or —NRN1−; RN1, if present, is independently —H or a substituent; RN2 is independently —H or a substituent; Y is independently —CH═ or —N═; Q is independently —(CH2)j-M-(CH2)k— wherein: j is independently 0, 1 or 2; k is independently 0, 1, or 2; j+k is 0, 1, or 2; M is independently O—, —S—, —NH—, —NMe-, or —CH2—; each of RP1, RP2, RP5, and RP4 is independently —H or a substituent; and additionally RP1 and RP2 taken together may be CH═CH—CH═CH—; and additionally RP1... |
| Somatostatin analogs and igf-i inhibition for breast cancer prevention | 20090325863 | 20091231 |
| The present invention relates generally to the use and application of compounds or agents, including somatostatin analogs, with effect on, affinity for, or specificity to SSTR3 and/or SSTR5 somatostatin receptors, particularly in the breast, for the treatment of breast hyperplasia, pre-neoplastic lesions and breast carcinoma and/or prevention or reduction of risk for breast cancer or treatment of breast cancer, including DCIS. The invention also relates to use of somatostatin analog SOM230 in treatment of breast hyperplasia and/or prevention or treatment of breast cancer. The invention includes assays and methods for screening and identifying breast hyperplasia with elevated SSTR3 and/or SSTR5 receptors and for chemotherapy and identifying compounds of use in the invention which are specific for, modulate via, or bind to SSTR3 and/or SSTR5 receptors.
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| Apparatus for increasing the reaction efficiency, especially the binding efficiency, between molecules and molecular moieties | 20090325822 | 20091231 |
| An apparatus for enhancing the contact frequency between two reactants capable of binding to one another, preferably between an analyzer molecule and an analyte molecule, especially for enhancing the binding effectiveness in bioanalysis arrays with the aid of micro- or nanomagnetic particles (75) set in motion in a controlled manner in the fluid reaction medium by means of magnetic fields generated by variably feedable electromagnets (3, 2, 20) arranged on both sides of the reaction fluid film. On one side of a reaction fluid film, especially of a microscope slide (4) comprising the reactants (63), the reaction liquid (70) comprising the reactants (73) and preferably a glass plate (5) covering the microbioanalysis array (6), is arranged close to a two-dimensional matrix (20) having a multitude of... |
| Nanoparticles having oligonucleotides attached thereto and uses therefor | 20090325812 | 20091231 |
| The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally,... |
| Detection of anomalies in traffic transmitted by a mobile terminal within a radiocommunication network | 20090325543 | 20091231 |
| To detect an anomaly in traffic sent by at least one mobile terminal (TM) in a radiocommunication network, a device capable of communicating with a radiocommunication network (RR) location register (HLR) comprises an evaluation module (ME) to increase, for a predetermined time interval, an authentication account (CA) assigned to the mobile terminal when security data (DS) are transmitted to a network unit to authenticate the mobile terminal, to detect an anomaly in the traffic sent by the mobile terminal if the authentication account exceeds a predefined upper limit value upon expiration of the predetermined time interval, and to transmit a message concerning such traffic anomaly to a unit in the network in charge of taking the necessary measures to eliminate the said anomaly.
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| Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma | 20090325201 | 20091231 |
| Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.
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| Compositions and methods for prognosis and therapy of liver cancer | 20090325160 | 20091231 |
| This invention provides a composition comprising the following polynucleotide probes: IL7R (AA485865) (SEQ ID NO:7), NDRGI (AA486403) (SEQ ID NO:8), EST1 (H50345) (SEQ ID NO:9), TRPC1 (AA017132) (SEQ ID NO:10), GFRA1 (AA512935) (SEQ ID NO:11), EST2 (AA454543) (SEQ ID NO:12), CLDN10 (R54559) (SEQ ID NO:13), DNALI1 (R93087) (SEQ ID NO:14), RBP5 (AA453198) (SEQ ID NO:15), EST3 (AA621761) (SEQ ID NO:16), EST4 (N63706) (SEQ ID NO:17), PCOLCE (AA670200) (SEQ ID NO:18), TDO2 (T72398) (SEQ ID NO:19), EST5 (T47454) (SEQ ID NO:20), HIST1H2BD (N33927) (SEQ ID NO:21), PXMP2 (N70714) (SEQ ID NO:22), ACAS2 (AA455146) (SEQ ID NO:23), ANAPC7 (T68445) (SEQ ID NO:24), EST6 (AA576580) (SEQ ID NO:25), RBP5 (N92148) (SEQ ID NO:26), ANXAI (H63077) (SEQ ID NO:27), CKB (AA894557) (SEQ ID NO:28), ITGBL1 (N52533) (SEQ ID NO:29), KPNA2... |
| Analysis of heterogeneous nucleic acid samples | 20090325153 | 20091231 |
| Methods for capturing and characterizing low frequency nucleic acid molecules indicative of diseases such as cancer (e.g. adenomas or early stage cancers) are provided. In some aspects, a low complexity capture technique is combined with a high complexity analytical technique. In some aspects, samples may be analyzed using a digital analysis and/or a single molecule sequencing technique.
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| Cancer prognostic diagnostic and treatment methods | 20090324595 | 20091231 |
| The invention disclosed herein provides methods comprising detection of EphB2 polypeptide and/or polynucleotide in a biological sample from a subject, wherein the detection of EphB2 is predictive or indicative of cancer prognosis for the subject. The invention also provides methods for selecting cancer treatment, methods comprising detection of EphB2 polypeptide and/or polynucleotide expression in colon adenomas, and methods for treating a colon adenoma disorder. Kits, compositions, and articles of manufacture are also provided.
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| Pharmaceutical composition comprising p43 protein for the treatment of gastric adenocarcinoma | 20090324573 | 20091231 |
| A pharmaceutical composition for the treatment of gastric adenocarcinoma is provided, wherein the pharmaceutical composition comprises p43 protein and pharmaceutically acceptable carriers, and does not comprise paclitaxel. A use of p43 protein for the treatment of gastric adenocarcinoma is also provided.
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| Diagnosis and treatment of cancer using anti-ereg antibody | 20090324491 | 20091231 |
| Methods that entail detection of an epiregulin (EREG) protein for cancer diagnosis are disclosed. In colon cancer, lung adenocarcinoma, pancreatic cancer, stomach cancer, and kidney cancer, the gene and protein expressions of EREG were frequently found to be elevated. Antibodies that recognize an EREG protein are used for diagnosing or treating cancer in the present invention. Pharmaceutical compositions, cell proliferation inhibitors, and anticancer agents containing an EREG-binding antibody as an active ingredient are also disclosed. Methods of inducing cell damage in EREG-expressing cells and methods of suppressing the proliferation of EREG-expressing cells by contacting the EREG-expressing cells with EREG-binding antibodies are also disclosed.
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| Status determination method and image forming apparatus | 20090322524 | 20091231 |
| A plurality of weak discriminators output determinations results about a status of an apparatus. Weight values are individually assigned to the determination results. By performing majority vote of the weighted determination results, the status of the apparatus is determined. The determination results are displayed on a single status indicating screen such that portions corresponding to a normal status are indicated in white while portions corresponding to an anomalous status are indicated in one or more colors other than white. The areas of the portions differ from one another depending on magnitudes of weight assigned to the determination results corresponding to the portions.
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| Permanent magnet rotor crack detection | 20090322373 | 20091231 |
| A method and apparatus for permanent magnetic (PM) rotor crack detection includes a sensor which monitors magnetic flux distribution of the PM rotor and identifies the presence of a crack in the PM rotor when a magnetic flux distribution change or anomaly is detected.
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| Spring counterbalance with failure detection | 20090322001 | 20091231 |
| A spring counterbalance mechanism balances a load with a spring. A cable has a protrusion fixed to the cable midway between two ends of the cable. The two free ends of the cable are fixedly coupled to one of the load or the spring, and a cable attachment is coupled to the remaining member. The cable passes through the cable attachment such that the protrusion is captive in the cable attachment and is movable between two stops in the cable attachment. The cable forms two segments each of which couples the spring to the load. The two segments of the cable pass over a pulley. A sensor coupled to the pulley senses rotation of the pulley allowing cable breakage to be detected by the anomalous rotation... |
| Method of searching for a thermal target | 20090321636 | 20091231 |
| In one embodiment, an efficient method is presented for aerial searching for a small thermal target in a search area, such as a single person in open water, using two thermal imagers or “cameras” coupled with a computer which presents data from the system to a human user for inspection. One of the two thermal imagers has a very wide field of view (WFOV) fixed forward of or below the aircraft. The other, narrow field-of-view (NFOV) imager has a high zoom capability but its field of view can be reoriented to geo-point to a location on command. The WFOV thermal imager collects images rapidly so that no individual image is blurred due to changes in the field of view (FOV) on the time-scale of the image... |
| Diagnosis of application performance problems via analysis of thread dependencies | 20090320021 | 20091224 |
| A “Performance Evaluator” provides various techniques for tracking system events to diagnose root causes of application performance anomalies. In general, traces of system events involved in inter-thread interactions are collected at application runtime. These traces are then used to construct inter-thread dependency patterns termed “control patterns.” Control patterns are then evaluated to determine root causes of performance anomalies. Where an application terminates abnormally or full traces cannot be collected for some reason, partial control patterns are constructed for that application. In various embodiments, “fingerprints” are then generated from full or partial control patterns and are matched to fingerprints corresponding to operations in other control patterns extracted from reference traces collected on the same or similar systems. Matched fingerprints or control patterns are then used to deduce... |
| Global disease surveillance platform, and corresponding system and method | 20090319295 | 20091224 |
| A computer-implemented method for identifying and assessing public health events, and a corresponding system and apparatus, includes capturing public health-related information from structured and unstructured sources, where the information is contained in one or more documents, extracting meta-data from the captured public health-related information, creating an index of the extracted meta-data; archiving the meta-data and the documents, where the index links meta-data to its associated document, processing the extracted meta-data according to one or more detection algorithms to determine if an anomaly exists, and where an anomaly exists, providing a public health event notification, and monitoring and evaluating the responses to the public health events.
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| Recombinant adenylate cyclase of bordetella sp. for diagnostic and immunomonitoring uses, method of diagnosing or immunomonitoring using said recombinant adenylate cyclase, and kit for diagnosing or immunomonitoring comprising said recombinant adenylate c | 20090317854 | 20091224 |
| Diagnostic testing and immunomonitoring that uses genetically detoxified Bordetella pertussis CyaA as a delivery system are effective in tracking any immune responses, such as those generated by infectious and non-infectious diseases, or vaccinations, for example. T cells previously stimulated by a given antigen can be restimulated in vitro by the same antigen fused or chemically coupled to CyaA or a fragment thereof. The invention includes diagnostic tests and immunomonitoring for tuberculosis by providing a delivery system, which can deliver the M. tuberculosis immunodominant proteins ESAT-6 and CFP-10, to human cells and non-human animal cells, such as cattle. In addition, fusion proteins between CyaA and cancer antigens are also provided as diagnostic tests and immunomonitoring systems for cancers, such as melanoma.
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| Diagnostic test for hepatocellular carcinoma | 20090317844 | 20091224 |
| A diagnostic test for hepatocellular carcinoma is based on increases in the concentration of two biochemical markers in a biological sample, alpha-1-acid glycoprotein (AAG) or isoforms thereof and alpha-fetoprotein (AFP) or glycoforms thereof. Levels of these markers may be performed using an immunoassay. Also disclosed is a diagnostic kit for use in these assays that comprises reagents for detecting and/or measuring in AAG and AFP in blood, serum or tissue samples. A point-of-care device for the performance of such measurements is also disclosed.
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| System and a method for improved crosshatch nanomachining of small high aspect three dimensional structures by creating alternating superficial surface channels | 20090317730 | 20091224 |
| This invention provides the user the ability to accurately nanomachine surfaces with reduced tip induced errors. Nanomaching has two types of errors, a first type of error is brought about by the tip's shape and its aspect ratio. A second type of error due to the tip's deflection as it works the material. Therefore, embodiments of the present invention minimizes tip deflection errors allowing allow high aspect Nano-bits to reliably and accurately nanomachine small high aspect three dimensional structures to repair and rejuvenate photomasks
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| Composition containing arazyme for the prevention and treatment of cancer | 20090317374 | 20091224 |
| The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising arazyme as an active ingredient. More precisely, when arazyme produced by Aranicola proteolycius was administered to the nude mice transplanted with human lung carcinoma cell line, weight gaining, inhibition of tumor cell growth and infiltration, and down-regulations of MMP-9, NF-κB and PCNA, were observed. In addition, when arazyme was treated to human breast cancer cells (MDA-MB-231), down regulations of p21, PCNA (Proliferating Cell Nuclear Antigen), VEGF (Vascular Endothelial Growth Factor), BCl2 (B-cell CLL/lymphoma 2), p-p38, PKC (Protein Kinase C) and MMP-1 (Matrix MetalloProteinase-1) which are involved in tumor cell growth, differentiation, proliferation and metastasis, were observed along with the up-regulation of catalase which inhibits tumor development. Therefore, the arazyme can... |
| Hybrid nanomaterials as multimodal imaging contrast agents | 20090317335 | 20091224 |
| The presently disclosed subject matter provides hybrid nanomaterials for use as magnetic resonance imaging (MRI), optical and/or multimodal contrast imaging agents. The hybrid nanomaterials comprise a polymeric matrix material and a plurality of coordination complexes, each coordination complex comprising a functionalized chelating group and a paramagnetic metal ion. The nanoparticle can further comprise a luminophore. Methods of synthesizing and using the nanoparticles are provided. The nanoparticles can be used to diagnose diseases, including cancer, cardiovascular disease, and diseases related to inflammation.
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| Method and instrumentation for determining a physical property of a particle | 20090316138 | 20091224 |
| Physical property determination of a particle or classification of the particle as a function of the physical property by evaluating scattered light profile from a single particle is disclosed. The particle may include chemical structures that vibrate as a function of a physical property of the particle. The physical property may include an absorptive property of the particle or a chemical composition. From a detected scattered light spectrum, at least two anomalous dispersive regions may be identified. The physical property of the particle may be determined as a function of the at least two regions. A system employing the physical property determination can achieve sensitivities useful for low particle density applications such as detection for biological and chemical agents.
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| Self-healing and self-cleaning tires utilizing active material actuation | 20090314406 | 20091224 |
| A self-healing and/or self-cleaning tire comprising at least one active material element configured when undergoing an actuation cycle to repair a structural anomaly, such as a crack or puncture, and/or remove a surface anomaly, such as foreign substances or objects adhered to or lodged in the tire.
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| Apparatus and method for preventing anomaly of application program | 20090313699 | 20091217 |
| An apparatus and method for preventing an anomaly of an application program are provided. More particularly, an apparatus and method for preventing an anomaly of an application program that detect and stop an anomaly on the basis of a behavior profile for an application program are provided. The apparatus includes a behavior monitor that detects behavior of an application program in operation, an anomaly detector that determines whether the detected behavior of the application program is an anomaly on the basis of a behavior profile of the application program in operation, and an anomaly stopper that stops the behavior of the application program determined as an anomaly by the anomaly detector. Possible application program behavior is stored according to its purpose in a behavior profile and... |
| Method for protecting a packet-based network from attacks, and security border node | 20090313698 | 20091217 |
| The invention relates to a security border node (2a) for protecting a packet-based network from attacks, comprising: an anomaly detection unit (10) for performing an anomaly detection, in particular a statistical analysis, on session control messages (11), in particular on SIP messages contained in a packet stream (5) received in the security border node (2a). The security border node further comprises a message context provisioning unit (13) for providing at least one session control message (11) to the anomaly detection unit (10) together with message context information (12, 17, 24) related to a client (22) and/or to a session (23) to which the session control message (11, 11a to 11f) is attributed. The invention also relates to a method for protecting a packet-based network from attacks,... |
| Fuel system diagnostics by analyzing engine cylinder pressure signal and crankshaft speed signal | 20090312941 | 20091217 |
| A method for distinguishing between combustion issues and sensor faults within an engine includes monitoring pressure sensor data from a cylinder within the engine, monitoring engine data describing combustion health from a source other than a pressure sensor, analyzing the pressure sensor data to diagnose an anomalous combustion event, comparing the anomalous combustion event to analysis of the engine data, and indicating a pressure sensor fault warning if the comparison diagnoses a pressure sensor fault.
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| Thermoelectric device and heat sink assembly with reduced edge heat loss | 20080314557 | 20081225 |
| An assembly that includes one or more thermoelectric devices and a heat sink and that corrects the problem of an uneven heating effect across the area occupied by the devices due to a lateral heat loss at the edges of the devices or other anomalies among the devices is constructed with a heat sink that contains voids in the slab or flat surface that is in thermal contact with the thermoelectric devices. The voids are located at or within the periphery of the area that is directly aligned with the thermoelectric devices and are concentrated in regions relatively close to the periphery, leaving an area in the center of the slab that is either void-free or of a relatively low void density.
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| System and method for suppressing redundant alarms | 20080316015 | 20081225 |
| The present invention is concerned with an alarm system and a method for suppressing redundant alarms in a monitored system. The alarm system comprises a process control unit, an FDI unit, a filter, and an alarm display unit. The process control unit detects anomalies in the monitored system and generates alarms corresponding to them. The FDI unit diagnoses failures in the monitored system and generates a failure-cause-effect graph comprising a list of generated alarms, along with the alarms corresponding to the causes and effects of each listed alarm. The FDI unit dynamically updates the failure-cause-effect graph concurrently with the generation of alarms by the process control unit and the diagnosis of failures by the FDI unit. The filter receives the generated alarms and identifies redundant and... |
| Image monitoring system | 20080317356 | 20081225 |
| In an image monitoring system, an image data acquisition unit takes in video signals from a camera to acquire image data. An image recognition unit carries out image recognition processing using an inputted image obtained from the image data acquisition unit. A reference image registration unit registers a reference image selected from among the inputted images. An image blur detection unit detects a difference in image blur between the reference image and the inputted image. A similarity computation unit computes a similarity between the reference image and the inputted image. A camera anomaly detection unit detects any anomaly in the camera from the difference in image blur and the similarity.
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| Compositions and methods for inhibiting growth of smad4-deficient cancers | 20080317667 | 20081225 |
| The present invention is in the fields of cell biology, immunology and oncology. The invention relates to the discovery that there is a relationship between the expression levels of the tumor suppressor gene smad4 (also known as dpc4) and integrin αvβ6, and the responsiveness of patient populations to αvβ6-active compounds and compositions (e.g., antibodies and other ligands that bind αvβ6), particularly in cancer cells from such patient populations, more particularly on carcinomas such as pancreatic carcinomas. The invention thus provides methods for determining the responsiveness of tumor cells (particularly those from pancreatic tumors) to such αvβ6-active compounds and compositions by examining the expression of αvβ6 and smad4 by the tumor cells, as well as methods of diagnosis and treatment/prevention of tumor progression using ligands, including antibodies... |
| Detection of anomalies in measurement of level of hypnosis | 20080317672 | 20081225 |
| The invention relates to detection of anomalies related to a measurement of the hypnotic level of a subject. In order to detect when a measure indicative of the hypnotic level of a subject is anomalous either due to a medical reason or due to an interference, the measure is monitored and state information indicative of the activity of the autonomous nervous system of the subject and drug effect information indicative of the hypnotic drug effect in the subject are employed to check whether the measure fulfills a predetermined consistency condition requiring that the measure changes consistently with at least one of the drug effect information and the state information. An anomaly, indicative of an abnormal change in the measure, is detected when the measure fails to... |
| Method for manufacturing resin-coated carbon nanomaterial and method for manufacturing carbon nanocomposite resin molded article | 20080317961 | 20081225 |
| A method of manufacturing a carbon nanomaterial coated with a resin is disclosed. A resin material and organic solvent are mixed to obtain a resin dispersion solution. A carbon nanomaterial is added to the resin dispersion solution, and mixed therewith to sufficiently disperse the carbon nanomaterial. Water is added to the carbon nanomaterial/resin dispersion solution to yield an aqueous solution. THF is removed with the water when the aqueous solution is filtered with a filter paper. The remaining article is dried to yield a resin-coated carbon nanomaterial.
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| Method of modifying carbon nanomaterials, composites incorporating modified carbon nanomaterials and method of producing the composites | 20080318026 | 20081225 |
| A polymer-carbon nanomaterial composite. The composite includes a polymer matrix; and plasma-modified carbon nanomaterials having surface functional groups attached thereto, wherein the carbon nanomaterial is selected from carbon nanotubes, carbon nanofibers, carbon nanoparticles, carbon black, nanodiamond, fullerenes, or combinations thereof. The invention also involves a method of making a polymer-carbon nanomaterial composite, and a method of modifying carbon nanomaterials.
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| Method of identifying cancer biomarkers and cancer progression | 20080318263 | 20081225 |
| An efficient method for identifying important cancer biomarkers and identifying progression of bladder cancer using pro-u-PA as a clinical tool is provided. Searching for biomarkers critical for bladder carcinoma diagnosis and prognosis, secreted proteomes of highly malignant U1 and pre-malignant U4 cell lines are first analyzed. Proteins in the cultured media of the U1 and U4 cell-lines were systematically examined by SDS-PAGE combined with MALDI-TOF mass spectrometry. Expression of pro-u-plasminogen activator (pro-u-PA) was confirmed by Western blot analysis and further evaluated. A statistically significant relationship between the low level and absence of pro-u-PA in urine with high stages and grades of the tumor samples was established. Constitutive expression of Ras dominant negative protein led to increased expression of pro-u-PA in cultured media, indicating the loss of... |
| Diagnostic and therapeutic use of a novel growth factor, neublasmin | 20080318853 | 20081225 |
| The present invention relates to the field of diagnostic and therapeutic use of proteins and genes, in particular to the diagnostic and therapeutic use of a secreted human hormone/growth factor, Neublasmin, and use or the gene coding for Neublasmin in the diagnosis and treatment of testicular disorders, in particular diagnosis and treatment of germ cell tumours and infertility. The invention also relates to use of Neublasmin in the treatment of CNS disorders. Neublasmin is expressed at high levels in human adult testicles and in developing mouse testicles from pn 22 and onwards. Expression or Neublasmin is strongly up-regulated in carcinoma in situ. Expression is also seen in foetal and adult brain.
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| Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging | 20080319324 | 20081225 |
| A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.
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| System for providing information to users sharing a nomadic experience | 20080320084 | 20081225 |
| The present invention relates to a system for providing information to one or more users sharing a nomadic experience. The system comprises client terminals (1071-1075) and a server platform (101). The server platform (101) consists of one or more first servers (103) for maintaining groups of users and one or more second servers (102) for interactively sharing information within a group of users. The system further comprises communication channels providing connectivity between client terminals (1071-1075) and the server platform (101).
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| Determination of participation in a malicious software campaign | 20080320095 | 20081225 |
| Sources of spam, such as botnets, are detected by analyzing message traffic for behavioral patterns and indications of suspicious content. The content of a known malicious source is analyzed. Message traffic associated with the known malicious source is analyzed. Associated message traffic includes messages sent directly from the known malicious source to recipients, and messages sent from the recipients to subsequent direct and indirect recipients. Portions of the content of the known malicious source are selected and content of associated message traffic is analyzed for an indication of the selected content. If the selected content is found in the content of a message, the source of the message is determined to be a source of spam. Associated message traffic is additionally analyzed for behavioral patterns, such... |
| Motor controller and electric power steering apparatus | 20080309270 | 20081218 |
| In a motor controller, in the case that occurrence of a failure of electric current flow is detected in any phase of a motor, a phase electric current command value changing in accordance with a secant curve or a cosecant curve with an asymptotic line at a predetermined rotation angle corresponding to the phase in which the failure of electric current flow has occurred is calculated. The calculated phase electric current command value is limited in such a manner as to become within a predetermined range. In the case that a rotation angle of the motor exists in a range in which the phase electric current command value is limited, the execution of an anomaly detection of a control system utilizing an electric current deviation of... |
| System and method for monitoring an optical communication system | 20080309925 | 20081218 |
| A monitoring system and method may be used to monitor an optical communication system. A monitoring system and method may be used to derive loop gain data sets from optical time domain reflectometry (OTDR) or coherent optical time domain reflectometry (COTDR) data. A monitoring system and method may also use differential monitoring techniques to obtain data representing gain tilt in the transmission system and to locate an anomalous loss or gain in the transmission system.
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| Digital signature on a smartcard | 20080310625 | 20081218 |
| A digital signature scheme for a “smart” card utilizes a set of prestored signing elements and combines pairs of the elements to produce a new session pair. The combination of the elements is performed partly on the card and partly on the associated transaction device so that the exchange of information between card and device does not disclose the identity of the signing elements. The signing elements are selected in a deterministic but unpredictable manner so that each pair of elements is used once. Further signing pairs are generated by implementing the signing over an anomalous elliptic curve encryption scheme and applying a Frobenius Operator to the normal basis representation of one of the elements.
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| Anomalous change detection in imagery | 20080310735 | 20081218 |
| A distribution-based anomaly detection platform is described that identifies a non-flat background that is specified in terms of the distribution of the data. A resampling approach is also disclosed employing scrambled resampling of the original data with one class specified by the data and the other by the explicit distribution, and solving using binary classification.
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| Methods for inhibition of proliferative disease, including hepatocellular carcinoma | 20080311090 | 20081218 |
| The present invention is related to a method for modulating expression of protein kinase C-alpha associated with proliferative diseases. The invention further relates to a screening method utilizing the association between transcription factors (MZF-1 and Elk-1) and their DNA binding element (PKC-.alpha. promoter) to identify novel anticancer agents.
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| Murine stem cells and applications thereof | 20080311092 | 20081218 |
| The invention relates to animal solid tumour models which comprise a transgenic non-human mammal containing in its genome a DNA construct that comprises a gene created and/or activated by a genetic anomaly associated with human cancer operatively bound to a promoter that directs the expression of the gene in Sca1+ cells. The invention also relates to stem cells capable of specifically expressing in stem cells human genetic anomalies associated with human pathologies. Applications of these models and stem cells, such as diagnostic, therapeutic and prophylactic applications for human diseases, and products and methods are provided.
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| Carcinoembryonic antigen fusions and uses thereof | 20080311137 | 20081218 |
| Polynucleotides encoding carcinoembryonic antigen (CEA) fusion proteins are provided, the CEA fusion proteins comprising a CEA protein, or functional variant thereof, fused to a substantial portion of an immunoenhancing element. The polynucleotides of the present invention can elicit an immune response in a mammal, which, in preferred embodiments, is stronger than the immune response elicited by a wild-type CEA. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying polynucleotides encoding CEA fusion proteins and discloses their use in... |
| Tumor markers for use in the diagnosis of colorectal carcinomas and/or metastases originating therefrom | 20080311567 | 20081218 |
| The invention relates to a method (i) for detecting a carcinoma, especially an adenocarcinoma, preferably a gastrointestinal carcinoma and more preferably a colorectal carcinoma, (ii) for predicting metastases, preferably liver metastases, depending on a primary colon carcinoma and/or (iii) for predicting the response of metastases to a 5-fluorouracil-containing chemotherapy. The inventive method comprises determining a gene expression profile of 120 marker genes or a selection thereof.
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| Method for quantitative measurement of gene expression for indentifying individuals at risk for bronchogenic carcinoma | 20080311569 | 20081218 |
| A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed.
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| Method for detecting cancer and a method for suppressing cancer | 20080312093 | 20081218 |
| An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in gastric carcinoma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells among these cancer-associated genes into cancer and inhibiting the transcription... |
| Polymorphs, solvates, and hydrate of 5-(4'-fluoro-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-5'-yl)-1-methyl-1h-pyrrole-2-carbonitrile | 20080312306 | 20081218 |
| Novel polymorph Form II and III, solvate Forms I, II, III, and IV, and the hydrate of 5-(4′-fluoro-2′-oxo-1′,2′-dihydrospiro[cyclopropane-1,3′-indol]-5′-yl)-1-methyl-1H-pyrrole-2-carbonitrile are provided, as are methods for preparing the same. Pharmaceutical compositions and kits containing these novel polymorphs, solvates, and hydrate, and combinations thereof are further provided, as are methods of contraception; treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, hormone-dependent carcinomas; treating symptoms of premenstrual syndrome and premenstrual dysphoric disorder; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; or treating symptoms of premenstrual syndrome using one or more of these polymorphs, solvates, or hydrate.
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| System analysis apparatus and system analysis method | 20080313644 | 20081218 |
| For an information system to be analyzed, restriction information indicating a restriction to be satisfied in the case where the information system is normal is acquired, and an anomalous state failing to satisfy the restriction is specified in a state transition model involving only the automatic transition. Also, the transition from an anomalous state to a normal state is retrieved in the state transition model involving only the manual transition thereby to output management work information indicating a management work specified by the retrieved manual transition as related to the anomalous state.
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| Composite nanomaterials for photocatalytic hydrogen production and method of their use | 20080302669 | 20081211 |
| The present invention is directed to a composite material for photocatalytic H2 production comprising: 1) a polymer gel; 2) a photocatalyst; and a protein based H2 catalyst. The invention also relates to a method to produce H2, comprising reacting an electron donor with a composite material comprising 1) a polymer gel, 2) a photocatalyst, and 3) a protein based H2 catalyst.
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| Digikey and digilock | 20080303630 | 20081211 |
| The emmiter (I.E. Cell Phone) will be provided with a software code for it to encrypt the message signaling a lock/unlock status to the magnetic lock using his private key, then a second encryption is performed using the receiver's public key thus achieving authentication, non-repudiation, and confidentiality.
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| Measuring conditions within a wireless sensor system | 20080303654 | 20081211 |
| A low cost, robust, wireless sensor that provides an extended period of operability without maintenance is described. The wireless sensors are configured to communicate with a base unit or repeater. When the sensor unit detects an anomalous ambient condition (e.g., smoke, fire, water, etc.) the sensor communicates with the base unit and provides data regarding the anomalous condition. The sensor unit receives instructions to change operating parameters and/or control external devices.
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| Methods and devices for providing robust nomadic wireless mesh networks using directional antennas | 20080304422 | 20081211 |
| The number of directional antennas and associated radios needed to ensure a nomadic wireless mesh network (NWMN) remains operational in the event of node or link failures, while minimizing delay and other unwanted effects, may be determined using novel methods and devices. Such a determination may reduce the number of antennas and radios a service or network provider normally uses, thus reducing its costs.
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| Broadband light source having a microstructured optical fiber for endoscopic and fluorescence microscopic examination devices, in particular for special devices for optical biopsy | 20080304788 | 20081211 |
| The invention relates to an arrangement for generating a broadband spectrum that can be used in particular as a light source for short coherence interferometry and confocal microscopy as well as endoscopic short coherence interferometry and endoscopic confocal microscopy. The arrangement comprises a laser, in particular a laser diode, for generating a short light pulse of wavelength λP and a microstructured optical fiber (1) of high nonlinearity, that has a null dispersion of the group velocity in the vicinity of the wavelength λP and an anomalous dispersion, as well as means for coupling the light pulse into the microstructured optical fiber.
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| Integrated processes for generating carbon monoxide for carbon nanomaterial production | 20080305028 | 20081211 |
| The integrated processes of the dry reforming or partial oxidation upstream of the carbon nanotube-producing reactor are described allowing the carbon monoxide to be produced on an as-needed basis, negating the need to transport carbon monoxide to the production site or store large quantities of carbon monoxide on-site. The apparatuses allowing to carry out such integrated processes are also provided. Carbon dioxide emissions may be eliminated from the carbon nanotube production process. This may be achieved by recycling the carbon dioxide byproduct and mixing it with the feed to the partial oxidation process.
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| Gas laser oscillator and gas laser beam machine | 20070297478 | 20071227 |
| A pressure of a laser gas in an enclosure (7) is detected by a gas pressure sensor (12), and a pressure comparison circuit (13) determines whether the thus-detected pressure is normal or anomalous. An electric current output from an inverter (10) that drives a blower (5) to cause a laser gas to flow back, is detected by a current detection circuit (9). A current comparison circuit (11) determines whether or not the output current is normal or anomalous. A result of a pressure comparison circuit (13) and a result of the current comparison circuit (11) are sent to an AND circuit (15) and performed AND processing. A result of the AND circuit (15), a result of the current detection circuit (9), and a result of the... |
| Inhibition of breast carcinoma stem cell growth and metastasis | 20070297983 | 20071227 |
| Disclosed is a method for inhibiting the growth of breast carcinoma stem cells. that express High Molecular Weight -Melanoma Associated Antigen (HMW-MAA). The method comprises administering to an individual a composition comprising an antibody reactive with HMW-MAA or a fragment of such an antibody in an amount effective to inhibit the growth of the breast carcinoma cells. Also provided are methods for inhibiting metastasis of breast carcinomas and methods for identifying HMW-MAA+ breast cancer stem cells.
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| Compositions and methods for tumor-targeted delivery of effector molecules | 20070298012 | 20071227 |
| The present application discloses the preparation and use of attenuated tumor-targeted bacteria vectors for the delivery of one or more primary effector molecule(s) to the site of a solid tumor. The primary effector molecule(s) of the invention is used in the methods of the invention to treat a solid tumor cancer such as a carcinoma, melanoma, lymphoma, or sarcoma. The invention relates to the surprising discovery that effector molecules, which may be toxic when administered systemically to a host, can be delivered locally to tumors by attenuated tumor-targeted bacteria with reduced toxicity to the host. The application also discloses to the delivery of one or more optional effector molecule(s) (termed secondary effector molecules) which may be delivered by the attenuated tumor-targeted bacteria in conjunction with the... |
| Antisense oligonucleotide to inhibit melanoma inhibitory activity mia | 20070299022 | 20071227 |
| An antisense oligonucleotide selected from the group of the sequence 5′-TTG CAT AAA CCC AAG GAG-3′ and modifications thereof a fragment having at least 8 nucleotides of the sequence 5′-TTG CAT AAA CCC AAG GAG-3′ and modifications thereof.
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| Diphenyl ox-indol-2-one compounds and their use in the treatment of cancer | 20070299102 | 20071227 |
| wherein at least one of X1 and X2 is a heteroatom substituent, e.g. 6-chloro-3,3-bis-(4-hydroxy-phenyl)-7-methyl-1,3-dihydro-indol-2-one.
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| Process for preparing tertiary phosphines | 20070299273 | 20071227 |
| The invention relates to a process for synthesizing tertiary phosphines by reacting halophosphines with organomagnesium compounds in the presence of copper compounds and optionally of salts.
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| Remotely reconfigurable system for mapping subsurface geological anomalies | 20070299632 | 20071227 |
| Methods and apparatus are provided for receiving, detecting and transmitting geophysical data from a plurality of electrodes placed in the soil utilizing a dynamically reconfigurable wireless control unit that is located on each electrode. Data from the control units is transmitted by a wireless signal to a centralized data processor for analysis. Control data is provided from a central control processor to the control unit by wireless transmission. The control unit, which is positioned, includes a multi-channel radio frequency transmitter/receiver and a processor to actuate relays and record data returns from the measured substrate soil for transmission to the central data processor. The control unit incorporates a changeable code or address to unambiguously identify itself, and its spatial relationship to other electrodes, to the central data... |
| Methods, devices, and systems for selectable repair of imaging devices | 20070291145 | 20071220 |
| An image sensor includes an array of pixels on a semiconductor device for sensing light incident on the pixel array and a plurality of anomaly registers comprising a plurality of nonvolatile elements. Each anomaly register identifies an anomalous pixel cluster and includes a location indicator with a row and column address and a size indicator with a horizontal and vertical range. In other embodiments, each anomaly register includes a first address, second address, first direction flag, and second direction flag. The first and second direction flags use a first state to indicate a row address or a second state to indicate a column address. The first and second direction flags combine to define an anomalous pixel cluster, a pair of anomalous pixel rows, or a pair... |
| Fibre channel dynamic zoning | 20070291785 | 20071220 |
| Zone information is automatically and dynamically configured and managed in a fibre channel storage area network upon detection of network events. Some examples of events that trigger automatic dynamic zone updates include virtual port creation, intrusion/anomaly detection, arbitration decision completion, misconfiguration detection, and device malfunction. The newly created/updated zones are propagated through the fibre channel fabric and provide access control.
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| Use of thymosin alpha 1 for preparing a medicament for the treatment of stage iv malignant melanoma | 20070292392 | 20071220 |
| It is described the use of thymosin alpha in combination with dacarbazine and optionally with Interferon alpha, for preparing a medicament for the treatment of malignant melanoma on stage IV characterized by distant unresectable metastases.
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| Use of thymosin alpha 1 for preparing a medicament for the treatment of stage iv malignant melanoma | 20070292393 | 20071220 |
| It is described the use of thymosin alpha in combination with dacarbazine and optionally with Interferon alpha, for preparing a medicament for the treatment of malignant melanoma on stage IV characterized by distant unresectable metastases.
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| Treatment of non-neuronal cancer using hsv-1 variants | 20070292394 | 20071220 |
| A mutant herpes simplex virus which has been modified in the γ34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.
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| Peptide minotopes of mycobacterial mannosylated lipoglycans and uses thereof | 20070292447 | 20071220 |
| The present invention relates to the identification of antigenic and immunogenic peptide-based mimicry of mannose-containing cell-wall compounds characterizing mycobacterial infectious agents, such as Mycobacterium tuberculosis. Amino acid molecules which are mimotopes of mannosylated lipoglycans, such as lipoarabinomannan (ManLAM), including at least one of the following characteristics: (a) being capable of binding to ManLAM binding antibodies; (b) being capable of eliciting production of ManLAM binding antibodies, are provided. Also diagnostic methods for diagnosing mycobacterial infections and methods of vaccinating subjects against such infections. The diagnostic and vaccination methods employ the provided amino acid molecules. Accordingly, a diagnostic kit and a vaccine for executing the aforementioned methods are provided.
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| Method and cmos-based device to analyze molecules and nanomaterials based on the electrical readout of specific binding events on functionalized electrodes | 20070292855 | 20071220 |
| A device having a functionalized electrode having a probe molecule, wherein the device has an ability to electrically detect a molecular binding event between the probe molecule and a target molecule by a polarization change of the functionalized electrode is disclosed. The device could also include an unfunctionalized electrode that does not have the probe molecule and the device could have an ability to electrically detect the molecular binding event between the probe molecule and the target molecule by a polarization change between the functionalized electrode and the unfuctionalized electrode.
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| Use of nanomaterials as effective viscosity modifiers in lubricating fluids | 20070293405 | 20071220 |
| Nanomaterials have been used as a supplement or replacement of traditional polymer-based viscosity modifiers for lubricants and other related fluids. Compared with traditional polymer-based viscosity modifiers, nanomaterials possess better viscosity-index modification functions, i.e., more even viscosity increase across the whole temperature range. Meanwhile, a cost-effective way of making nanomaterials have been developed based on commercially available graphite materials, and the resulting nanoparticles of graphite are nanodisks (nanoplates). Furthermore, it provides a viscosity modifier which exhibits temporary shear loss, which can contribute to fuel economy, but no permanent shear loss.
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| System and method for anomaly detection | 20070294187 | 20071220 |
| A system and method for detecting one or more anomalies in a plurality of observations is provided. In one illustrative embodiment, the observations are real-time network observations collected from a stream of network traffic. The method includes performing a discrete decomposition of the observations, and introducing derived variables to increase storage and query efficiencies. A mathematical model, such as a conditional independence model, is then generated from the formatted data. The formatted data is also used to construct frequency tables which maintain an accurate count of specific variable occurrence as indicated by the model generation process. The formatted data is then applied to the mathematical model to generate scored data. The scored data is then analyzed to detect anomalies.
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| Method and apparatus for identifying a failure mechanism for a component in a computer system | 20070294591 | 20071220 |
| One embodiment of the present invention provides a system that identifies a failure mechanism for a component. The system first constructs a library of failure signatures from a set of components, wherein each failure signature in the library characterizes a known failure mechanism associated with a component in the set of components. Next, the system receives a telemetry signal which is measured from a component under surveillance. The system then determines if there is an anomaly in the telemetry signal. If so, the system performs pattern-matching operations between the telemetry signal and failure signatures in the library. Next, if a match is found, the system identifies the failure mechanism for the component under surveillance based on the matching failure signature.
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| Firewallapparatus, method and system | 20070294756 | 20071220 |
| A storage firewall architecture, method and system that works in parallel with existing security technologies and, inter alia, provides application software authentication, user authentication & authorization in the execution of an application, examination, verification, and authentication of all storage access requests, monitoring of protected storage to detect & repair anomalous changes, encryption of protected storage, both data and software, provisioning (deployment) of patches, configuration changes, and software through a secure synchronization link to a configuration and patch management server, and server-based system administration & configuration to prevent malware from penetrating local configuration mechanisms.
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| Method for estimating the fan-in and/or fan-out of a node | 20070286085 | 20071213 |
| A method for detecting anomalies in traffic patterns and a traffic anomalies detector are presented. The method and the detector are based on estimating the fan-in of a node, i.e. the number of distinct sources sending traffic to a node, based on infrequent, periodic sampling. Destinations with an abnormally large fan-in are likely to be the target of an attack, or to be downloading large amounts of material with a P2P application. The method and the anomalies detector are extremely simple to implement and exhibit excellent performance on real network traces.
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| Method and apparatus for identifying repeated patterns | 20070286472 | 20071213 |
| In an exemplary method, repeated patterns are identified in a strip-like product. In the method the strip-like product is observed by at least one camera, and at least one digital image signal comprised of pixels is created for inspection. The image signal is searched for anomalies comprised of one or more pixels. A search image is created of any detected anomaly and its neighbourhood, and the search image is used to convolute the image signal being examined, creating a response image signal. The response image signal is used to determine image areas in the image signal being examined that are substantially similar to the search image.
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| Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as therapeutic compounds | 20070287838 | 20071213 |
| The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., and more particularly to compounds of the formula (I): wherein: J is independently —O— or —NRN1—; RN1, if present, is independently —H or a substituent; RN2 is independently —H or a substituent; Y is independently —CH═ or —N═; Q is independently —(CH2)j-M-(CH2)k— wherein: j is independently 0, 1 or 2; k is independently 0, 1, or 2; j+k is 0, 1, or 2; M is independently —O—, —S—, —NH—, —NMe—, or —CH2—; each of RP1, RP2, RP3, and RP4 is independently —H or a substituent; and additionally RP1 and RP2 taken together may be —CH═CH—CH═CH—; L is independently: a... |
| Method and system for anomaly detection using a collective set of unsupervised machine-learning algorithms | 20070289013 | 20071213 |
| An anomaly detection system comprising, one or more distributed sensors for gathering network or log data; one or more generators for generating discovery rules based on a collective set of pattern discovery algorithms including one or more unsupervised machine learning algorithms; one or more detectors for detecting abnormal patterns in the network or log data gathered by the sensors based on the discovery rules generated by the generator; and one or more correlation engine for determining intrusion counter measures based on matching features of one or more detected abnormal patterns with correlation rules.
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| Dc-ac converter, and method for supplying ac power | 20070279946 | 20071206 |
| First and second semiconductor switches which are activated alternately are provided between ends of a primary winding and a common potential point, wherein a DC power supply voltage is supplied to a center tap. An electric current flowing into a load is fed back to thereby subject the semiconductor switches to PWM control. Series circuits consisting of capacitors and semiconductor switches are connected between the center tap of the primary winding and the ends of the same. The semiconductor switches are activated in synchronism with the first and second semiconductor switches, thereby preventing occurrence of an anomalous high voltage, which would otherwise be caused at the time of switching operation.
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| Recombinant fusion-enzyme with repair activity on dna lesions produced by uv radiation; its usage, preparation and purification method; a method to stabilize enzymes and treatment methods | 20070280923 | 20071206 |
| A recombinant fusion enzyme repairs DNA damaged by UV radiation, and the method of preparing recombinant fusion enzyme. The method includes the fusion of an enzyme coded by a gene isolated from Micrococcus luteus and a stabilizing peptide having the amino acid sequence described in SEQ ID No 2. A treatment method intended to repair DNA lesions produced in cells exposed to UV radiation and to repair cell anomalies or lesions produced by sun exposure. Such treatment consists of the administration of a effective amount of recombinant fusion enzyme, or a vector containing the gene coding to the recombinant fusion enzyme, to patients requiring such treatment.
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| Compositions and methods for the treatment and diagnosis of neoplastic and infectious diseases | 20070280937 | 20071206 |
| Methods and compositions for the detection, prevention and treatment of infectious diseases, primary and metastatic neoplastic diseases, including, but not limited to human sarcomas and carcinomas are provided. In particular, the detection, prevention and treatment of infectious diseases and cancer mediated and/or indicated by the presence and co-localization of a member of the anti-apoptotic Bcl-2-associated athanogene (Bag) family, especially Bag4 and membrane-bound heat shock protein (Hsp) on the cell surface of diseased tissue or cells are described.
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| Detection of lymph node metastasis from gastric carcinoma | 20070281305 | 20071206 |
| Methods, compositions and articles are directed to diagnosing the lymph node metastasis from gastric carcinoma, differentiating between negative lymph nodes and lymph nodes with metastasis from gastric carcinoma, testing tissue samples of for determining gastric carcinoma staging status.
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| Endovascular apparatus | 20070282424 | 20071206 |
| Percutaneous treatment of aortic aneurysms and like vascular anomalies by an apparatus and method wherein the apparatus is delivered via catheter and comprises a sleeve with at least one peripheral conduit which is caused to assume an expanded, rigid configuration by the introduction of a chemical or mechanical hardening means, whereby the sleeve is caused to assume an open cylindrical configuration for fluid flow therethrough.
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| System, method, and computer program product for forensic auditing | 20070282617 | 20071206 |
| A system and method of determining whether fraudulent accounting activity may have taken place in a business. First, financial data regarding the business is received. A determination is then made as to whether any anomalies are present in the financial data. Such anomalies are referred to herein as “red flags”. Any given red flag may be a manifestation of one or more particular fraud tactics. Conversely, for any particular fraud tactic, a number of associated red flags may be present. For each of a plurality of fraud tactics, the number of red flags associated with the tactic is determined. For each fraud tactic having an associated red flag, a determination is made as to whether the tactic took place in view of the number of red... |
| System and methods for filtering electronic communications | 20070282770 | 20071206 |
| A system and method is provided for filtering anomalous electronic communications, for example spam. In particular the method provides for detecting behavior data or behavioral characteristics of a source of the electronic communication, processing of the behavioral characteristic data to determine anomalous communications and filtering anomalous communications. Beneficially source behavior data comprises that of a sending host and its neighboring hosts. Preferably, by employing a machine learning algorithm, detection is based on knowledge obtained during a training period.
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| Method and system of monitoring and prognostics | 20070282773 | 20071206 |
| A neural network learns the operating modes of a system being monitored under normal operating conditions. Anomalies can be automatically detected and learned. A control command can be issued or an alert can be issued in response thereto.
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| Heat blanket | 20060289454 | 20061228 |
| The heat blanket (10) comprises an operative unit (20) and a control/power supply unit (40) which can be electrically connected on one side to the power mains and on the other side to the operative unit (20). The operative unit (20) comprises a foldable sheet (21) and a linear heating element (22) distributed in the sheet (21), with a first and second conductor extending one along the other, separated by a first electrically insulating material and enclosed by a second electrically insulating material; the first and second conductor are electrically connected to the control/power supply unit (40) and have respective first terminals inside the panel which are connected together. The control/power supply unit (40) comprises a power supply group (41) for the heating element (22), intended... |
| System and method for high precision clock recovery over packet networks | 20060291479 | 20061228 |
| An innovative system and method for achieving high precision clock recovery, i.e. reconstruction of the clock signal having the same frequency, over a packet switched network. The proposed method utilizes a minimum network delay approach, which overcomes the problems caused by delay variation of the network and filters out network jitter, such as noise jitter and other “singular” anomalies causing latency deviations. Minimum network delay is defined herein as the time delay in which a packet remains in the network under assumption that all transmission queues through which the packet passes are empty.
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| Self-similar laser oscillator | 20060291521 | 20061228 |
| A laser producing high energy ultrashort laser pulses comprises a normal dispersion segment, a gain segment, an anomalous dispersion segment with negligible nonlinearity and an effective saturable absorber arranged to form a laser cavity. Each segment is optically interconnected so that a laser pulse will propagate self-similarly therein. (A pulse that propagates in a self-similar manner is sometimes referred to as a “similariton.”) With this laser the limitations of prior art laser oscillators are avoided. Also provided are means for pumping the gain medium in the laser cavity, and means for extracting laser pulses from the laser cavity. The laser cavity is preferably a ring cavity. Preferably the laser is configured to achieve unidirectional circulation of laser pulses therein. This configuration is scalable to much higher... |
| Pb39, a gene dysregulated in prostate cancer, and uses thereof | 20060292627 | 20061228 |
| A novel gene, PB39, that is up-regulated, or over-expressed, in prostate cancer has been identified. The gene has been identified by means of its cDNA obtained by reverse transcription of the corresponding mRNA. Microdissection of prostate glands that had been surgically removed from prostate cancer patients revealed a novel up-regulated transcript in an aggressive prostate carcinoma. Differential analysis for the presence of this gene was carried out from the same glands by comparing tanscription in microdissected normal prostatic epithelium versus that in microdissected invasive tumor. The transcript was over-expressed in 5 of 10 prostate carcinomas examined. A variant transcript was over-expressed in 4 of 4 prostate carcinomas, and was found in 1 of 4 normal samples. The invention provides a purified and isolated nucleic acid that... |
| Stat3 decoy oligonucleotides and uses therefor | 20060293264 | 20061228 |
| A composition is provided that is useful in treating cancers in which STAT3 is activated, such as squamous cell carcinomas including squamous cell carcinoma of the head and neck. The composition comprises an effective amount of a STAT3 decoy and a pharmaceutically acceptable carrier. Also provided are methods of treating such cancers and methods of modulating STAT3 transcriptional activation in a cell.
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| Method for treating cancer | 20060293386 | 20061228 |
| It is an object of the present invention to provide a method for cancer treatment to suppress cancer, specifically hepato cellular carcinoma. There is discovered effective suppression of the progression of hepatocellular carcinoma with gabexate mesilate, a non-anticancer drug that has not been used as an anticancer drug. Gabexate mesilate in the amount of 100-300 mg dissolved in 150-300 ml of physiological saline or of 5% glucose is administered by intravenous drip infusion. The administration can be carried out noninvasively with little or no pain to patients. Concomitant use with embolization strongly suppresses hepatocellular carcinoma.
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| Therapeutic and diagnostic applications of prostatic acid phosphatase in prostate cancer | 20060294615 | 20061228 |
| Presented is a therapeutic method to treat prostate carcinomas in mammals comprising the administration of cellular PAcP protein. Also presented is a method to diagnose androgen-insensitive prostate carcinomas by determining the expression level of cellular PAcP in the prostate carcinomas, a decrease in expression being indicative of androgen-insensitivity. A promoter region that is specifically expressed in prostate tissue is presented, as is a xenograft animal model that mimics human prostate carcinomas in the expression of cellular PAcP.
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| Anti-cd71 monoclonal antibodies and uses thereof for treating malignant tumor cells | 20060286030 | 20061221 |
| The present invention provides novel anti-CD71 monoclonal antibodies, in particular mouse-human chimeric anti-CD71 monoclonal antibodies, advantageously associated to effector cells for triggering ADCC mechanisms. Anti-CD71 antibodies, as well as pharmaceutical compositions containing them, are useful for inhibiting proliferation and/or killing malignant tumor cells, especially metastatic cutaneous and uveal melanoma cells.
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| Anticarcinoma antibodies and uses thereof | 20060286113 | 20061221 |
| A novel single domain antibody AFAI and fragments thereof which has specific affinity for binding to carcinoma, and especially lung carcinoma. This antibody, and portions thereof, can be used, inter alia in the diagnosis and treatment of carcinoma.
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| Synthetic gene encoding rhesus monkey carcinoembryonic antigen and uses thereof | 20060286114 | 20061221 |
| Synthetic polynucleotides encoding rhesus monkey carcinoembryonic antigen (CEA) are provided, the synthetic polynucleotides being condon-optimized for expression in a human cellular environment. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenovial vector and plasmid constructs carrying codon-optimed rhesus monkey CEA and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
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| Recombinant adenylate cyclase of bordetella sp. for diagnostic and immunomonitoring uses, method of diagnosing or immunomonitoring using said recombinant adenylate cyclase, and kit for diagnosing or immunomonitoring comprising said recombinant adenylate c | 20060286613 | 20061221 |
| Diagnostic testing and immunomonitoring that uses genetically detoxified Bordetella pertussis CyaA as a delivery system are effective in tracking any immune responses, such as those generated by infectious and non-infectious diseases, or vaccinations, for example. T cells previously stimulated by a given antigen can be restimulated in vitro by the same antigen fused or chemically coupled to CyaA or a fragment thereof. The invention includes diagnostic tests and immunomonitoring for tuberculosis by providing a delivery system, which can deliver the M. tuberculosis immunodominant proteins ESAT-6 and CFP-10, to human cells and non-human animal cells, such as cattle. In addition, fusion proteins between CyaA and cancer antigens are also provided as diagnostic tests and immunomonitoring systems for cancers, such as melanoma.
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| Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) | 20060287523 | 20061221 |
| This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diaminophenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and... |
| Method and system for interaction between a vehicle driver and a plurality of applications | 20060287787 | 20061221 |
| A method and system for at least one of communication and interaction between a vehicle driver and a plurality of at least one of integrated and non-integrated applications like, e.g., native vehicle applications and/or aftermarket applications and/or nomad applications is disclosed. Especially, such a method and system for managing the at least one of communication and interaction by means of an interaction manager is provided, by which this at least one of communication and interaction is conducted or managed in such a way that risks and impairments for the safety and comfort of the driver are reduced considerably and workload and distraction of the driver are reduced considerably as well.
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| Methods of networking interrogation devices for structural conditions | 20060287842 | 20061221 |
| Methods of operating an interrogation system that has a plurality of patches attached to a host structure. Each patch is capable of generating a diagnostic wave and/or developing a sensor signal in response to the diagnostic wave. In each method, a Euclidean undirected graph is generated by forming a plurality of paths, wherein each path connects two of the patches and the length of the path is shorter than a preset limit. Then, a directed graph is generated by assigning a propagation direction of the diagnostic wave to each path. Structural condition index (SCI) values are measured by use of the directed graph and, based on the SCI values, the host structure is scanned for anomalies. The directed graph is reconfigured to enhance accuracy in determining... |
| Receptor array for managing network traffic data | 20060288296 | 20061221 |
| Systems and methods are provided for filtering and processing network traffic data and for providing visual representations of the processed data. A lens may identify or filter source and destination addresses in an address space, or identify and filter other network information of interest. A receptor array can be configured to process selected traffic data parameters such as IP header information. The visual representations can be used in real-time network management and to identify anomalous conditions such as distributed denial of service attacks. Image data can be subsequently processed by graphics processors to enhance or identify features in the images. The receptor array may include one or more receptors. Each receptor may have multiple sub-receptors to manage different types of information or distinct data ranges. Furthermore,... |
| Method of detecting network worms | 20060288415 | 20061221 |
| A method of detecting network worms include the following steps: (1) Profiling the TCP connection information collected from the protected network, quantifying the plurality of statuses contained in the TCP connection information; (2) Clustering the connection profiles to discover all the anomaly clusters that are specified by the condition composing of several adaptive thresholds; (3) Correlating the anomaly clusters to result in a new cluster graph or to extend an existing cluster graph; (4) Issuing a security incident about the worm propagation according to the propagation condition that also composes of several adaptive thresholds; and (5) Keeping and maintaining the status of the cluster graphs.
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| Phase sampling protection device | 20060279234 | 20061214 |
| A phase sampling protection device substantially includes a phase sampling circuit coupled between a tube circuit and a protection circuit. The phase sampling circuit captures a voltage signal and a current phase signal of the tube circuit for comparison, using phase comparing technique to detect an anomaly of the tube, if the tube doesn't function normally, then the phase sampling circuit driving the protection circuit to shut down the power supply of the tube to keep a transformer from burning down and other safety issues from happening.
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| Compositions and methods of treating and diagnosing hepatoma | 20060280725 | 20061214 |
| Disclosed are pharmaceutical compositions and methods of treating hepatoma by administering to patients or other populations of cells agents that selectively inhibit the uptake of glutamine by hepatocarcinoma cells, causing the concomitant apoptosis of hepatocarcinoma cells. Preferred agents target the amino acid transporter B0 (ATB0) protein for inhibition. Disclosed are antisense polynucleotides that reduce the expression of ATB0 in hepatocarcinoma cells, causing those cells to reduce the uptake of glutamine and subsequently undergo selective apoptosis.
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| Pharmaceutical composition useful for the treatment of hepatocellular carcinoma | 20060280817 | 20061214 |
| The present invention relates to anticancer activity against hepatocellular carcinoma of an extract and fraction isolated from flowers of Butea monosperma. Particularly, this invention relates to anticancer activity against hepatocellular carcinoma of a composition containing markered flavonoid glycosides such as butrin and isobutrin in the range of 2 to 9% by weight, isolated from the flowers of Butea monosperma by extracting the flowers with polar solvent like ethanol, methanol, aqueous ethanol or water, removing fatty non-polar constituents by triturating the extract with solvents such as ethylene chloride, methylene chloride, chloroform or ethyl acetate, suspending the residue in water, extracting with n-butanol and freeze drying the aqueous part.
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| Method of diagnosing colon and gastric cancers | 20060281081 | 20061214 |
| Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer—associated gene that discriminate between colon or gastric cancer and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of colonic cancer and method of vaccinating a subject against colon or gastric cancer.
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| Bisindolyl maleimides useful for treating prostate cancer and akt-mediated diseases | 20060281787 | 20061214 |
| In a second embodiment, the invention provides a method of treating androgen-independent prostatic adenocarcinoma comprising administering to a patient in need thereof a therapeutically effective amount of compound of formula (I) or a pharmaceutically acceptable salt thereof. In a third embodiment, the invention provides a method of treating an AKT-mediated disease selected from the group consisting of glioblastoma, colon cancer, pancreatic cancer, ovarian cancer, endometrial cancer, and renal cell cancer, comprising administering to a patient in need thereof a therapeutically effective amount of compound of formula (I) or a pharmaceutically acceptable salt thereof.
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| Method and apparatus to override daughterboard slots marked with power fault | 20060282595 | 20061214 |
| Having detected an anomalous fault in a peripheral I/O slot, a processor entity may need to perform some remedial action, wherein the peripheral slot may have a fault line. First a voltage may be detected on the slot. Processor entity may set a fault if a voltage is found. A hotplug controller which may provide outputs that the processing entity may store as a fault syndrome word. The service processor or operating system, either during initial program load, or at another time, may detect that the fault could be a false fault depending on a set of predefined conditions and following the mechanism described here can then clear the fault earlier set. If an action from a previous device list is set, then there may be... |
| System and method for detecting faults in a system | 20060282708 | 20061214 |
| To determine the cause of a problem, evaluating and tracing how an individual request traverses through various components in the system makes possible new detection techniques. The present invention relates to detecting faults in a computer system. In accordance with an embodiment of the invention, a method and apparatus detects a fault in a system by receiving a request and generating a trace based on the request. The trace is a sequence of components used to service the request. The method and apparatus also compares the trace with a stored automaton to determine whether the trace is an anomaly. The stored automaton describes traces.
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| Polarizer based on a nanowire grid | 20060273067 | 20061207 |
| The preferred embodiment provides for development and use of an array of nanowires with a period smaller then 150 nm for applications such as an optical polarizer. To manufacture such structures the preferred embodiment employs a hard nanomask. This nanomask includes a substantially periodic array of substantially parallel elongated elements having a wavelike cross-section.
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| Rotary position sensor | 20060273784 | 20061207 |
| A robust, low cost, compact and highly accurate rotary position sensor is disclosed for measuring the relative angular position (within a range≦180°) of a housing or stator and a rotor. The housing carries a galvanomagnetic sensing element and is adapted for fixation to a relatively fixed portion of a host system. The rotor carrying a magnet is disposed for rotation about a fixed axis with respect to the stator and is interconnected to a relatively moving portion of the host system through intermediate linkage. The magnet is juxtaposed in substantially axial alignment with the galvanomagnetic sensing element for magnetic interaction therewith. The housing defines a cavity to receive potting material for encasing the galvanomagnetic sensing element and an adjacent buffer cavity interconnected by a weir, which... |
| System and method for variable threshold sensor | 20060273896 | 20061207 |
| A sensor system that provides an adjustable threshold level for the sensed quantity is described. The adjustable threshold allows the sensor to adjust to ambient conditions, aging of components, and other operational variations while still providing a relatively sensitive detection capability for hazardous conditions. The adjustable threshold sensor can operate for extended periods without maintenance or recalibration. In one embodiment, the sensor is self-calibrating and runs through a calibration sequence at startup or at periodic intervals. In one embodiment, the adjustable threshold sensor is used in an intelligent sensor system that includes one or more intelligent sensor units and a base unit that can communicate with the sensor units. When one or more of the sensor units detects an anomalous condition (e.g., smoke, fire, water, etc.)... |
| Electrical device enclosure | 20060274485 | 20061207 |
| A robust, low cost, compact and highly accurate rotary position sensor is disclosed for measuring the relative angular position (within a range ≦180°) of a housing or stator and a rotor. The housing carries a galvanomagnetic sensing element and is adapted for fixation to a relatively fixed portion of a host system. The rotor carrying a magnet is disposed for rotation about a fixed axis with respect to the stator and is interconnected to a relatively moving portion of the host system through intermediate linkage. The magnet is juxtaposed in substantially axial alignment with the galvanomagnetic sensing element for magnetic interaction therewith. The housing defines a cavity to receive potting material for encasing the galvanomagnetic sensing element and an adjacent buffer cavity interconnected by a weir,... |
| Systems and methods for improved gaussian noise filtering | 20060274962 | 20061207 |
| According to some embodiments, systems and methods for improved Gaussian noise filtering may be provided. In some embodiments, a system, method, and/or article of manufacture may be operable to receive, at a Gaussian noise filter, video input comprising data associated with a plurality of video pixels, identify a pixel from the plurality of pixels that is associated with an anomaly, determine if the identified pixel is a singularity pixel, filter the video input, in the case that the pixel is a singularity pixel, utilizing a singularity filter, filter the video input, in the case that the pixel is not a singularity pixel, utilizing a threshold filter, refine the filtered video input utilizing data associated with edge detection to create video output, and provide the video output... |
| Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds | 20060275209 | 20061207 |
| This invention pertains to methods of [11C]-radiolabelling “phenothiazine” and “phenothiazine-like” compounds, which have a pendant group (which is a primary amino group; a cationic primary imino group; a secondary amino group; a cationic secondary imino group; a primary imino group; or a secondary imino group), by reaction with [11C]methyl trifluoromethanesulfonate (CF3SO2O11CH3), also known as [11C]methyl triflate. This reaction converts the pendant group into a [11C]methyl-labelled pendant group. The resulting [11C]-radiolabelling product is useful, for example, as an in vivo positron emission tomography (PET) tracer, for example, for patients suffering from melanoma, the most serious form of skin cancer, and tauopathy (e.g., Alzheimer's disease). The present invention also pertains to the resulting [11C]-radiolabelling products, compositions comprising them, their use in methods of (e.g., PET) imaging, their use... |
| Novel cancer-associated gene | 20060275302 | 20061207 |
| The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having... |
