|| List of recent Noma-related patents
|Decentralized input/output resource management|
A shared input/output (io) resource is managed in a decentralized manner. Each of multiple hosts having io access to the shared resource, computes an average latency value that is normalized with respect to average io request sizes, and stores the computed normalized latency value for later use.
|Method and system for securing a vehicle offered for rent, and vehicle rental facility implementing such a system or such a method|
The invention relates to a method (200) for securing a traveling electric vehicle offered for rent; said method including the following steps: measuring (206) at least one value of at least one parameter relating to said vehicle, comparing (208) the value of said parameter to at least one predetermined value, and reporting (220) an anomaly, on the basis of the result of the comparison step; wherein the reporting step is initiated by a so-called central site remote from the vehicle. Said invention likewise relates to a system implementing such a method and an automated vehicle rental facility implementing such a method or such a system..
|Devices and methods for minimally invasive reduction of parathyroid adenomas|
Apparatus and methods for performing glandular reduction are described. In an example embodiment, an apparatus includes a needle-like probe containing a scintillation detector for converting gamma and x-rays emitted from a radio-labeled gland into photons that are then carried from the probe through a fiberoptic cable to a photodetector, and a therapy element for causing selective tissue destruction by directing energy toward the radio-labeled gland..
|Fibroblasts cellular model for assessing efficacy of cancer treatments by shh/ptch pathway antagonists|
A cellular model is described that targets dysregulation or inappropriate activation of the sonic hedgehog/patched (shh/ptch) pathway. Also described, is a screening method using this cellular model to screen for pharmacological compounds that can treat or prevent skin cancer, in particular, basal cell carcinoma, (bcc) lesions..
|Methods, kits and computer program products using hepatocellular carcinoma (hcc) biomarkers|
Methods of determining the presence or risk of liver disease or other diseases in a subject include measuring a level of a saccharide selected from n-acetylneuraminic acid, n-acetylglucosamine, n-acetylgalactosamine, or a combination thereof on one or more glycosylated proteins and the total amount of alpha-fetoprotein in a biological sample from the subject. Glycosylated proteins include but are not limited to vascular endothelial growth factor, lymphatic vessel endothelial hyaluronan receptor, e-cadherin, alpha 1 acid glycoprotein, glypican-3, galectin-3, and any combination thereof.
|Microrna patterns for the diagnosis, prognosis and treatment of melanoma|
The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microrna (mir) molecules in a patient in need thereof.. .
|Tumor biomarkers for pancreatic marker|
This invention pertains generally to the fields of molecular biology and medical diagnosis. More particularly this invention provides novel biomarkers for the detection of pancreatic cancer comprising at least one messenger rna and/or up-regulated peptide in pancreatic cancer.
|Use of hoxa9 gene as a biomarker for the detection of hepatocellular carcinoma|
A method of detecting hepatocellular carcinoma includes the steps of: detecting a methylation level of a cpg site of hoxa9 gene in a biological sample taken from a suspected subject; and comparing the methylation level to a reference methylation level of a cpg site of hoxa9 gene in another biological sample taken from a normal subject not suffering from hepatocellular carcinoma, wherein when the methylation level is higher than the reference methylation level, the suspected subject is likely to suffer from hepatocellular carcinoma, and wherein each of the biological samples is selected from the group consisting of a blood sample, a serum sample, and a plasma sample.. .
|Measurement of pka for cancer characterization|
A method for characterizing a carcinoma in a subject. The method comprises assaying a sample of a bodily fluid derived from the subject for extracellular pka activity and comparing the activity to a reference value.
|Monoclonal antibody against human non-small cell lung carcinoma and use thereof|
The invention discloses a monoclonal antibody against human non-small cell lung carcinoma and a use of the monoclonal antibody. The monoclonal antibody is secreted by a hybridoma cell strain which is deposited as cctcc access number no.: c201172.
|Method for decreasing radioresistance and growth, metastasis and infiltration of cancer cells through regulating expression or activity of tm4sf4 in non-small cell lung cancer|
The present invention relates to a pharmaceutical composition or an anticancer agent for preventing and treating non-small cell lung cancer, containing a substance for regulating the expression or activity of transmembrane 4 l six family member 4 (tm4sf4). More specifically, the present invention relates to a use of a substance for regulating the expression or activity of tm4sf4 as an anticancer drug or an anticancer agent with respect to non-small cell lung cancer, wherein it was ascertained that it is possible to decrease the growth, metastasis, and infiltration of adenocarcinoma cells and radioresistance by decreasing the expression of tm4sf4 in adenocarcinoma among non-small cell lung cancers and to decrease the growth, metastasis, and infiltration of the cells and radioresistance by increasing the expression of tm4sf4 in other non-small cell lung cancers except adenocarcinoma..
|Methods for treating a tumor using an antibody that specifically binds grp94|
Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated braf.
|Method of chekcing the appearance of the surface of a tyre|
The sub-images of the inner surface of the tyre to be checked containing an anomaly are located using a classifier suitable for identifying the areas of the common reduced factorial space containing the anomalies.. .
|Anomaly detection using a kernel-based sparse reconstruction model|
A method and system for detecting anomalies in video footage. A training dictionary can be configured to include a number of event classes, wherein events among the event classes can be defined with respect to n-diminensional feature vectors.
|System and method for wireless collaborative verification of global navigation satellite system measurements|
Systems and methods are disclosed herein for verifying the quality of global navigation satellite system (gnss) measurements. The system includes a gnss receiver, a wireless communications device, and a fault detection processor.
|Pressure type flow control system with flow monitoring, and method for detecting anomaly in fluid supply system and handling method at abnormal monitoring flow rate using the same|
A pressure type flow control system with flow monitoring includes an inlet, a control valve including a pressure flow control unit connected downstream of the inlet, a thermal flow sensor connected downstream of the control valve, an orifice installed on a fluid passage communicatively connected downstream of the thermal flow sensor, a temperature sensor provided near the fluid passage between the control valve and orifice, a pressure sensor provided for the fluid passage between the control valve and orifice, an outlet communicatively connected to the orifice, and a control unit including a pressure type flow rate arithmetic and control unit receiving a pressure signal from the pressure sensor and a temperature signal from the temperature sensor, and a flow sensor control unit to which a flow rate signal from the thermal flow sensor is input.. .
|Detecting network intrusion and anomaly incidents|
In an embodiment, a method comprises: using computing apparatus, receiving one or more data streams, determining one or more characteristics of the one or more data streams, and based on the one or more characteristics of the one or more data streams, determining one or more tags for the one or more data streams; determining whether the one or more tags indicate one or more malicious patterns representative of network intrusions; in response to determining that the one or more tags indicate one or more malicious patterns representative of network intrusions: generating, based on the one or more tags, one or more aggregated alert streams; applying one or more rules to the one or more aggregated alert streams and receiving a result indicating whether a network intrusion is in progress; in response thereto, determining and executing one or more remedial actions.. .
|Automated detection of a system anomaly|
A method for automated detection of a real it system problem may include obtaining monitor measurements of metrics associated with activities of a plurality of configuration items of the it system. The method may also include detecting anomalies in the monitor measurements.
|Systems and methods for detecting anomalies|
Apparatus and method for detecting anomalies in a computer system are disclosed herein. In some embodiments, multiple probes are executed on an evolving data set.
|Using both social media and non-social media information to identify anomalous behavior|
A method, system and computer program product for identifying anomalous behavior (e.g., suspicious transactions). Information from at least one social media source (e.g., a posting) and from at least one non-social media source (e.g., a booking) are monitored.
|Heterocyclic compounds for the treatment of cf|
The present invention provides pyridin-oxadiazole/thiadiazole derivatives of formula i wherein a is n or cr 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type cftr to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (ibs, ibd, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed..
|Diagnostic use of prosomatostatin|
The present invention relates to a method for the diagnosis, prognosis, monitoring and risk assessment of disturbances of the gastrointestinal tract activity and/or function and/or disturbances of the nutritional condition, with the exception of somatostatinoma, in a patient comprising the steps of: providing a sample of a bodily fluid of a patient; determining the level of prosomatostatin 1-64 or fragments thereof in said sample; correlating the level of prosomatostatin 1-64 or fragments thereof to the diagnosis, prognosis and risk assessment of disturbances of the gastrointestinal tract activity and/or function and/or disturbances of the nutritional condition, with the exception of somatostatinoma, in said patient, wherein said fragments have a length of at least 6 amino acid residues. The invention also relates to an antibody and a kit containing at least two antibodies..
|Tire bead area rotation apparatus|
Disclosed is a machine for rotation of the bead area of a green tire so that the bead areas are parallel and concentric in order to remove potential anomalies that can occur to a green tire bead portion during pre-cure handling, storing or during shaping in the tire press. The tire apparatus orients the beads of the green tire parallel and square to one another and also rotates the bead area of the tire into the proper configuration prior to cure.
|Recombinant adenylate cyclase toxin of bordetella induces t cell responses against tumoral antigens|
An immunogenic composition comprising a recombinant protein comprising a bordetella cyaa, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided.
|Annexin a2 as immunological target|
Annexina2 (anxa2), a member of the annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. Annexina2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane annexina2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas.
|Somatic mutations in atrx in brain cancer|
We determined the sequence of atrx and daxx in 447 cancers from various sites. We found mutations most commonly in pediatric glioblastoma multiformae (gbm) (11.1%), adult gbm (6.5%), oligodendrogliomas (7.7%) and medulloblastomas (1.5%); and showed that alternative lengthening of telomeres (alt), a telomerase-independent telomere maintenance mechanism found in cancers that have not activated telomerase, perfectly correlated with somatic mutations of either gene.
|Wet etchants including at least one etch blocker|
Methods for preventing isotropic removal of materials at corners faulted by seams, keyholes, and other anomalies in films or other structures include use of etch blockers to cover or coat such corners. This covering or coating prevents exposure of the corners to isotropic etch solutions and cleaning solutions and, thus, prevents higher material removal rates at the corners than at smoother areas of the structure or film.
|Dynamic operational watermarking for software and hardware assurance|
This disclosure addresses systems and methods for the protection of proprietary information by monitoring operational watermarks of an apparatus. A monitoring device may receive logical or physical watermark data from a defended apparatus.
|Learning machine based detection of abnormal network performance|
In one embodiment, techniques are shown and described relating to learning machine based detection of abnormal network performance. In particular, in one embodiment, a border router receives a set of network properties xi and network performance metrics mi from a network management server (nms), and then intercepts xi and mi transmitted from nodes in a computer network of the border router.
|Navigation system with anomaly detection mechanism and method of operation thereof|
A method of operation of a navigation system includes: determining a classification model for a target field for assessing a point of interest; determining a cluster for the target field for assessing the point of interest; and determining an anomaly based on the classification model and the cluster for displaying on a device.. .
|Anomaly detection in interaction data|
Method of automated anomaly detection includes obtaining a corpus of interaction data. Regular interaction data is identified from the corpus of interaction data with a processor.
|Catch members for occluder devices|
Devices and techniques for modifying and maintaining a configuration of an occlusion device for the closure of physical anomalies, such as an atrial septal defect, a patent foramen ovale (pfo), and other septal and vascular defects are described. The devices and techniques relate particularly to, but are not limited to, modifying and maintaining a configuration of a pfo occluder made from a polymer tube.
|Inhibition of cell proliferation|
The disclosed modulators of rb:raf-1 interactions are potent, selective disruptors of rb:raf-1 binding, with ic50 values ranging from 80 nm to 500 nm. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer.
|Method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm|
The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, ef-i-delta, or m2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.. .
|Fusion gene of kif5b gene and ret gene, and method for determining effectiveness of cancer treatment targeting fusion gene|
In order to identify a gene that can serve as an indicator for predicting the effectiveness of a drug treatment of cancer and to provide a novel method for predicting the effectiveness of a drug treatment targeting said gene, lung adenocarcinomas were subjected to whole-transcriptome sequencing. As a result, in-frame fusion transcripts between the kif5b gene and the ret gene were identified.
|Quantitative multiplex methylation-specific pcr|
Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation specific pcr (qm-msp), multiple genes can be quantitatively evaluated from samples usually yielding sufficient dna for analyses of only 1 or 2 genes.
|Immune-stimulating photoactive hybrid nanoparticles|
Provides is a therapeutic technology that combines the phototoxic and immune-stimulating ability of photodynamic therapy with the widespread effectiveness of the immune system to reduce the viability of such as cancer cells and tumors. The nanoparticle compositions of the disclosure combine an immunostimulant with a photosensitizer using a nanoparticle delivery platform.
|Cytotoxic t lymphocyte inducing immunogens for prevention treatment and diagnosis of cancer|
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as pancreatic carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a ctl response against pancreatic and other cancers..
|Gene signature for predicting prognosis of patients with solid tumors|
Disclosed herein is a driver gene signature for predicting survival in patients with solid tumors, such as hepatocellular carcinoma (hcc) and breast cancer. The gene signature includes ten tumor-associated genes, sh2d4a, ccdc25, elp3, dlc1, prosc, sorbs3, hnrpd, paqr3, phf17 and dck.
|Ddr2 mutations as targetable features of melanoma or basal cell carcinoma|
Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the ddr2 gene. Further, a distinct subgroup of braf-mutated melanomas have somatic mutations in the ddr2 gene as well.
|Pthrp, its isoforms and antagonist thereto in the diagnosis and treatment of disease|
The present invention is directed to the diagnosis and treatment of diseases, preferably the inhibition of tumor growth and its progression to metastatic sites, through the inhibition of the production of pthrp, its isoforms or pthrp signalling. The present invention is also directed to methods of inhibiting the pthrp1-173 isoform through antagonists thereof, including monoclonal antibodies and sirna directed there against.