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Nicotinamide

Nicotinamide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Nicotinamide mononucleotide derivatives and their uses
Metro International Biotech, Llc
October 12, 2017 - N°20170290850

The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (...
Skin care and cosmetic composition
Infinitus (china) Company Ltd.
October 05, 2017 - N°20170281988

A skin care composition and product having beneficial effects on skin conditions/symptoms, such as reducing wrinkles and skin roughness and improving skin elasticity, etc. The composition has three separate parts: a powder part, an aqueous part and an emulsion part. The power part comprises oligopeptide-1 and ginseng saponin. The aqueous part comprises glycyrrhiza glabra root extract, artemisia capillaris flower ...
6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide inhibitors of phd
Infinitus (china) Company Ltd.
September 28, 2017 - N°20170275271

Which are useful as inhibitors of phd, pharmaceutical compositions thereof, methods for treatment of conditions associated with hif, processes for making the compounds and intermediates thereof.
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Methods for preparing tire treads with advantageous wear characteristics
Bridgestone Americas Tire Operations, Llc
August 31, 2017 - N°20170247530

A method for preparing a vulcanizable composition of matter, the method comprising mixing rubber, silica, silica coupling agent, a strong base, and nicotinamide to form a masterbatch, introducing a curative to the masterbatch, and mixing the curative into the masterbatch to form a vulcanizable composition of matter.
Methods for preparing tire treads with advantageous wear characteristics
Bridgestone Americas Tire Operations, Llc
August 17, 2017 - N°20170233558

A method for preparing a vulcanizable composition of matter, the method comprising mixing, within a first mixing step, rubber, silica, and silica coupling agent to form a first masterbatch composition, adding nicotinamide to the first masterbatch composition and mixing within a second mixing step to form a second masterbatch composition, and adding a curative to the second masterbatch composition and ...
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Crystalline form of nicotinamide riboside
W. R. Grace & Co.-conn.
July 27, 2017 - N°20170210774

Provided are crystalline forms of nicotinamide riboside, including a form i of nicotinamide riboside chloride according to formula (i). Also disclosed are pharmaceutical compositions comprising the crystalline form i of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions. In other aspects, the present disclosure pertains to methods comprising administering to a subject the crystalline form i of nicotinamide ...
Preparation and use of crystalline beta-d-nicotinamide riboside
Glaxosmithkline Intellectual Property (no.2) Limited
July 20, 2017 - N°20170204131

Provided herein are crystalline beta-d-nicotinamide riboside chloride compositions and methods of preparation and use thereof. Also provided are related pharmaceutical compositions and methods of use thereof. The crystalline beta-d-nicotinamide riboside chloride compositions may be used to treat a disease or disorder that would benefit from increased nad levels including a mitochondrial disease or disorder, insulin resistance, a metabolic syndrome, diabetes, ...
4,5-dihydroisoxazole derivatives as nampt inhibitors
Aurigene Discovery Technologies Limited
July 20, 2017 - N°20170204092

The present invention provides 4,5-dihydroisoxazole derivatives of formula (i), which may be therapeutically useful, more particularly as nampt inhibitors. Wherein, ring a, l1, l2, x1, x2, x3, z, r1, r2, r3, r4, r5, m, n, p and q have the meanings given in the specification and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases ...
Compositions and methods for treating hyperproliferative epidermal diseases
Dermipsor Ltd.
July 13, 2017 - N°20170196897

The present invention provides compositions and methods for use in the treatment of hyperproliferative dermal diseases. Specifically, the present invention teaches pharmaceutical compositions for topical administration that include a vitamin d metabolite, calcipotriol, and nicotinamide in a combination that is particularly effective in treating and in the maintenance therapy of psoriasis and other related dermal disorders and diseases.
Nicotinamide mononucleotide derivatives and their uses
Dermipsor Ltd.
July 06, 2017 - N°20170189434

The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (...
Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
Dermipsor Ltd.
July 06, 2017 - N°20170189433

Wherein r1 is —c(═o)—x—(c2-c18 straight chain or branched) alkyl or —c(═o)—x—(c2-c18 straight chain or branched) alkenyl; each r2 is independently selected from hydrogen, and a —c(o)—x—(c1-c18 straight chain or branched) alkyl or a —c(o)—...
Form a of mesylate for nicotinamide derivatives and preparation method and application thereof
Shanghai Suntrong Biotechnology Co., Ltd.
June 29, 2017 - N°20170183310

The invention discloses a form a of mesylate for nicotinamide derivatives and preparation method and application thereof, wherein the xrpd pattern of the form a of mesylate for nicotinamide derivatives has a diffraction peak at 2θ=5. 34, 10. 341, 14. 438, 15. 841, 17. 32, 18. 301, 18. 68, 19. 005, 19. 577, 20. 26, 21. 161, 21. 859, 22. 379, 23. 04, 23. 5, 24. 177, 24. 959, 25. 881, 26. 641, 27. 18, 28. 3, 28. 999, 29. 501, 31. 96, 32. 258, 33. 999, 36. 798, 37. 38 and 41. 297 with the error range of the 2θ values being ±0. 2. The form a of mesylate for nicotinamide derivatives provided by the ...
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Use of beta-nicotinamide mononucleotide in preparation of health-care products for preventing and treating arteriosclerosis and ...
Bontac Bio-engineering (shenzhen) Co., Ltd
June 15, 2017 - N°20170165283

A health care product having nicotinamide mononucleotide as the active ingredient, and the use of nicotinamide mononucleotide in preparing health care products for the prevention and treatment of arteriosclerosis and cardiovascular and cerebrovascular diseases caused by arteriosclerosis.
Use of beta-nicotinamide mononucleotide in preparation of drugs for preventing and treating arteriosclerosis and cardio-cerebrovascular ...
Bontac Bio-engineering (shenzhen) Co., Ltd.
June 15, 2017 - N°20170165282

A medication having nicotinamide mononucleotide as the active ingredient, and the use of nicotinamide mononucleotide in preparing medications for the prevention and treatment of arteriosclerosis and cardiovascular and cerebrovascular diseases caused by arteriosclerosis.
Tranilast compositions and cocrystals
Nuformix Limited
June 08, 2017 - N°20170158618

New tranilast complexes and new tranilast cocrystals are disclosed. These include a 1:1 tranilast nicotinamide complex, a 1:1 tranilast nicotinamide cocrystal, a 1:1 tranilast saccharin complex, a 1:1 tranilast saccharin cocrystal, a 1:1 tranilast gentisic acid complex, a 1:1 tranilast gentisic acid cocrystal, a 1:1 tranilast salicylic acid complex, a 1:1 tranilast salicylic acid cocrystal, a 1:1 tranilast urea complex, a 1:1 tranilast urea cocrystal, a 1:1 tranilast 4-aminobenzoic acid complex, ...
Method and compositions for treating chronic inflammatory disorders
Nuformix Limited
May 25, 2017 - N°20170143752

A method and composition for treating chronic inflammatory disorders comprising a pharmaceutically acceptable carrier suitable for oral administration or injection and containing a therapeutic amount of a complex of dietary supplement ingredients comprising nicotinamide, quercetin, curcumin, epa, dha, hesperetin and glychrrhizin.
Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (nampt)
Nuformix Limited
May 18, 2017 - N°20170137441

The present invention relates to compounds and compositions for the inhibition of nampt, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
Topical compositions and methods for skin lightening
Avon Products, Inc.
May 18, 2017 - N°20170135926

Embodiments of the invention are generally directed to compositions useful for reducing pigmentation in the skin. The composition may further include other depigmenting agents such as nicotinamide and its melanasome transfer-inhibiting derivatives, 3,3′-thiodipropanoic acid and its tyrosinase-inhibiting derivatives, or resorcinol and its tyrosinase-inhibiting derivatives, in a topically acceptable vehicle.
Method for producing 2-amino-6-methylnicotinic acid
Agro-kanesho Co., Ltd.
May 11, 2017 - N°20170129858

The present invention provides a method for producing 2-amino-6-methylnicotinic acid represented by formula [i], wherein the production method comprises: (a) reacting 2-chloro-3-cyano-6-methylpyridine represented by formula [ii] in an ammonia aqueous solution to obtain a reaction solution containing 2-amino-6-methylnicotinamide represented by formula [iii]; and (b) removing the ammonia from the reaction solution, then reacting the 2-amino-6-methylnicotinamide ...
Method for preparing nicotinamide riboside
The Procter & Gamble Company
May 04, 2017 - N°20170121746

A method of making nicotinamide riboside, nicotinamide riboside derivatives, or mixtures thereof is disclosed. The method involves contacting at least the following materials to form a solution: i) α-d-ribose-1-phosphate, α-d-ribose-1-phosphate derivatives, or mixtures thereof; ii) nicotinamide, nicotinamide derivatives, or mixtures thereof; iii) one or more pentosyl transferases (e. C. 2. 4. 2); iv) and one or more ...
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