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Nicotinamide

Nicotinamide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Enzymatic systems and methods for synthesizing nicotinamide mononucleotide and nicotinic acid mononucleotide
June 14, 2018 - N°20180163243

Enzyme-based systems and methods for synthesizing the nad precursors nmn and namn are disclosed. Such methods and systems utilize a mutated form of phosphoribosylpyrophosphate synthetase (prs) that is superactive and/or other enzyme or enzyme combinations that are immobilized onto a solid surface.
Method for preparing nicotinamide mononucleotide (nmn)
Bontac Bio-engineering(shenzhen) Co.,ltd
June 14, 2018 - N°20180162895

The present invention provides a method for preparing nicotinamide mononucleotide (nmn) by biocatalysis. The method includes a step of catalytically reacting a plurality of raw materials including nicotinamide, atp, and ribose in the presence of nicotinamide phosphoribosyltransferase (nampt), ribose phosphate pyrophosphokinase, and ribokinase, to prepare the nmn..
Pharmaceutical compositions
Novartis Ag
June 07, 2018 - N°20180153899

Pharmaceutical compositions comprising the drug substance (r,e)-n-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1h-benzo[d]imidazol-2-yl)-2-methylisonicotinamide and processes to prepare these compositions.. .
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Use of nad precursors for breast enhancement
University Of Iowa Research Foundation
May 31, 2018 - N°20180147225

Certain embodiments of the invention provide a method for breast enhancement in a female mammal (e.g., a human) in need thereof, comprising administering an effective amount of a nicotinamide adenine dinucleotide (nad) precursor to the mammal.. .
Nicotinamide compositions and the therapeutic use thereof
Apet Holding B.v.
May 24, 2018 - N°20180140553

The present invention relates to compositions and methods for the prophylaxis or treatment of deficiencies in essential amino acid absorption and metabolism and/or of a pathology or symptom associated there with. In particular the invention concerns the treatment and/or prevention of adhd, add and autism spectrum disorders.
Tranilast compositions and cocrystals
Nuformix Limited
May 03, 2018 - N°20180118662

New tranilast complexes and new tranilast cocrystals are disclosed. These include a 1:1 tranilast nicotinamide complex, a 1:1 tranilast nicotinamide cocrystal, a 1:1 tranilast saccharin complex, a 1:1 tranilast saccharin cocrystal, a 1:1 tranilast gentisic acid complex, a 1:1 tranilast gentisic acid cocrystal, a 1:1 tranilast salicylic acid complex, a 1:1 tranilast salicylic acid cocrystal, a 1:1 tranilast urea complex, a 1:1 tranilast urea cocrystal, a 1:1 tranilast 4-aminobenzoic acid complex, ...
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Sensors, methods and kits for detecting nicotinamide adenine dinucleotides
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
March 29, 2018 - N°20180087083

The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (nad) and nicotinamide adenine dinucleotide phosphate (nadp). Provided is a sensor molecule for fluorescence or luminescence-based detection of a nicotinamide adenine dinucleotide analyte, in particular for detecting the concentrations of nad+, nadp′ and/or the ratios of the concentrations of nad′/...
Crystalline form of nicotinamide riboside
W. R. Grace & Co.-conn.
March 29, 2018 - N°20180086783

Provided are crystalline forms of nicotinamide riboside, including a form i of nicotinamide riboside chloride according to formula (i). Also disclosed are pharmaceutical compositions comprising the crystalline form i of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions.
Ocular formulations for drug-delivery and protection of the anterior segment of the eye
March 22, 2018 - N°20180078531

Or its free base, and a second active agent selected from nicotinic acid, nicotinamide, and vitamin k, and a combination thereof, for treating ocular neovascularization. The present application also relates to pharmaceutical compositions comprising particles of compound-i or its free base, and suspension formulations comprising the particle compositions of compound-i or its free base..
Label-free single and multi-photon fluorescence spectroscopy to detect brain disorders and disease: alzheimer, parkinson and ...
March 22, 2018 - N°20180078142

A label free single or multi-photon optical spectroscopy for measuring the differences between the levels of fluorophores from tryptophan, collagen, reduced nicotinamide adenine dinucleotide (nadh), and flavins exist in brain samples from a of alzheimer's disease (ad) and in normal (n) brain samples with label-free fluorescence spectroscopy. Relative quantities of these molecules are shown by the spectral profiles of the ...
Amelioration of neural deficits associated with diabetes
Neuralstem, Inc.
March 15, 2018 - N°20180071267

Methods for treating non-systemic deficiencies associated with diabetes using 2-amino substituted nicotinamides or their pharmaceutically acceptable salts.. .
Administration of nicotinamide mononucleotide in the treatment of disease
Washington University
February 22, 2018 - N°20180050054

Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (nmn) to a subject.
Method for producing coenzyme and transformant set for coenzyme production
Japan Science And Technology Agency
February 15, 2018 - N°20180044683

The present invention provides a method for synthesizing nad+ or nadh in an enzyme reaction system requiring nad+ or nadh so as to supplement nad+ lost due to thermal decomposition in the enzyme reaction system, and a transformant set for coenzyme production used in the method. That is, the present invention relates to a method for producing a coenzyme including ...
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Use of nadph in preparing medicines for treatment of heart diseases
Chongqing Institute Of Bench-to Bed Bioengineering Technology Co., Ltd.
February 08, 2018 - N°20180036332

The use of reduced nicotinamide adenine dinucleotide phosphate (nadph) in preparing medicines for the treatment of heart diseases, and medicines for the treatment of heart diseases using nadph as the active ingredient, said heart diseases including cardiac damage, myocardial infarction, and cardiomyopathy.. .
Crystalline form of nicotinamide riboside
W. R. Grace & Co.-conn.
February 01, 2018 - N°20180030079

Provided are crystalline forms of nicotinamide riboside, including a form ii of nicotinamide riboside chloride: nicotinamide riboside chloride. Also disclosed are pharmaceutical compositions comprising the crystalline form ii of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions.
N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine
Glucox Biotech Ab
January 25, 2018 - N°20180022715

The compound n2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamineor a pharmaceutically acceptable salt of said compound. The compound is useful the treatment of a condition or disorder associated with nicotinamide adenine dinucleotide phosphate oxidaseactivity.
Amido thiadiazole derivatives as nadph oxidase inhibitors
Genkyotex Suisse Sa
December 07, 2017 - N°20170348296

The present invention is related to amino thiazole derivatives of formula (i), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to nicotinamide adenine dinucleotide phosphate oxidase (nadph oxidase).. .
Compositions, methods and kits for reducing lipid levels
Nusirt Sciences, Inc.
November 30, 2017 - N°20170340615

Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites in combination with leucine and/or a leucine metabolite, with or without resveratrol..
Methods for treating cancer
November 02, 2017 - N°20170312300

The invention relates to nicotinamide riboside or a derivative thereof for use in the treatment and/or prevention of liver or pancreatic cancer in a subject. Additionally, the invention relates to an in vitro method for designing a customized therapy for a subject diagnosed with a liver cancer or pancreatic cancer or suffering early signs of chronic liver damage or ...
Use of nadh or salt thereof in preparation of drugs or health-care products for treating ...
Bontac Bio-engineering (shenzhen) Co., Ltd
October 26, 2017 - N°20170304346

Disclosed is use of nicotinamide adenine dinucleotide (nadh) or a salt thereof in the preparation of drugs or health-care products for treating phenylketonuria (pku), wherein a single dose of the nadh or a salt thereof is 1-100 mg.. .
Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as nad+ ...
Chromadex Inc.
October 26, 2017 - N°20170304338

Compositions are provided including nicotinic acid riboside (“nar”), and derivatives thereof including 1-(2′,3′,5′-triacetyl-beta-d-ribofuranosyl)-nicotinic acid (“nar triacetate” or “narta”); or derivatives of a reduced form of nicotinic acid riboside (“narh”), including 1-(2′,3′,5′-triacetyl-beta-d-ribofuranosyl)-1,4-dihydronicotinic acid (ȁ...
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