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Nicotinamide

Nicotinamide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for producing coenzyme and transformant set for coenzyme production
Japan Science And Technology Agency
February 15, 2018 - N°20180044683

The present invention provides a method for synthesizing nad+ or nadh in an enzyme reaction system requiring nad+ or nadh so as to supplement nad+ lost due to thermal decomposition in the enzyme reaction system, and a transformant set for coenzyme production used in the method. That is, the present invention relates to a method for producing a coenzyme including ...
Microsomal bioreactor for synthesis of drug metabolites
The Board Of Regents For Oklahoma State University
February 15, 2018 - N°20180044657

Reusable microsomal biocatalytic systems (bioreactors) constructed on carbon nanostructure modified electrodes are provided. The bioreactors comprise stable, biologically active immobilized enzymes such as human cytochromes p 450 (cyps) and their redox partner proteins, e. G. Cyp-nadph (reduced nicotinamide adenine dinucleotide phosphate) reductases (cpr), on the carbon nanostructure surface. The immobilized enzymes may be present in liver microsomes, such as human liver ...
Use of nadph in preparing medicines for treatment of heart diseases
Chongqing Institute Of Bench-to Bed Bioengineering Technology Co., Ltd.
February 08, 2018 - N°20180036332

The use of reduced nicotinamide adenine dinucleotide phosphate (nadph) in preparing medicines for the treatment of heart diseases, and medicines for the treatment of heart diseases using nadph as the active ingredient, said heart diseases including cardiac damage, myocardial infarction, and cardiomyopathy.
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N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine
Glucox Biotech Ab
January 25, 2018 - N°20180022715

The compound n2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamineor a pharmaceutically acceptable salt of said compound. The compound is useful the treatment of a condition or disorder associated with nicotinamide adenine dinucleotide phosphate oxidaseactivity. A pharmaceutical composition comprising the compound.
Amido thiadiazole derivatives as nadph oxidase inhibitors
Genkyotex Suisse Sa
December 07, 2017 - N°20170348296

The present invention is related to amino thiazole derivatives of formula (i), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to nicotinamide adenine dinucleotide phosphate oxidase (nadph oxidase).
Compositions, methods and kits for reducing lipid levels
Nusirt Sciences, Inc.
November 30, 2017 - N°20170340615

Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites in combination with leucine and/or a leucine metabolite, with or without resveratrol.
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Use of nadh or salt thereof in preparation of drugs or health-care products for treating ...
Bontac Bio-engineering (shenzhen) Co., Ltd
October 26, 2017 - N°20170304346

Disclosed is use of nicotinamide adenine dinucleotide (nadh) or a salt thereof in the preparation of drugs or health-care products for treating phenylketonuria (pku), wherein a single dose of the nadh or a salt thereof is 1-100 mg.
Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as nad+ ...
Chromadex Inc.
October 26, 2017 - N°20170304338

Compositions are provided including nicotinic acid riboside (“nar”), and derivatives thereof including 1-(2′,3′,5′-triacetyl-beta-d-ribofuranosyl)-nicotinic acid (“nar triacetate” or “narta”); or derivatives of a reduced form of nicotinic acid riboside (“narh”), including 1-(2′,3′,5′-triacetyl-beta-d-ribofuranosyl)-1,4-dihydronicotinic acid (ȁ...
Combined anticancer drug sensitivity-determining marker
October 19, 2017 - N°20170299597

The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the tca cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, ...
Use of nicotinamide riboside, nicotinic acid riboside, and nicotinamide mononucleotide, reduced nicotinyl compounds, and nicotinoyl ...
October 19, 2017 - N°20170296564

Methods for delivering at least one compound selected from nicotinamide riboside (nr), nicotinic acid riboside (nar), and nicotinamide mononucleotide (nmn), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin b1), riboflavin (vitamin b2), niacin (vitamin b3), and pyridoxine (vitamin b6), to an infant human subject in need of said compound or compounds are provided.
Nicotinamide mononucleotide derivatives and their uses
Metro International Biotech, Llc
October 12, 2017 - N°20170290850

The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (...
Skin care and cosmetic composition
Infinitus (china) Company Ltd.
October 05, 2017 - N°20170281988

A skin care composition and product having beneficial effects on skin conditions/symptoms, such as reducing wrinkles and skin roughness and improving skin elasticity, etc. The composition has three separate parts: a powder part, an aqueous part and an emulsion part. The power part comprises oligopeptide-1 and ginseng saponin. The aqueous part comprises glycyrrhiza glabra root extract, artemisia capillaris flower ...
6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide inhibitors of phd
September 28, 2017 - N°20170275271

Which are useful as inhibitors of phd, pharmaceutical compositions thereof, methods for treatment of conditions associated with hif, processes for making the compounds and intermediates thereof.
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Methods for preparing tire treads with advantageous wear characteristics
Bridgestone Americas Tire Operations, Llc
August 31, 2017 - N°20170247530

A method for preparing a vulcanizable composition of matter, the method comprising mixing rubber, silica, silica coupling agent, a strong base, and nicotinamide to form a masterbatch, introducing a curative to the masterbatch, and mixing the curative into the masterbatch to form a vulcanizable composition of matter.
Methods for preparing tire treads with advantageous wear characteristics
Bridgestone Americas Tire Operations, Llc
August 17, 2017 - N°20170233558

A method for preparing a vulcanizable composition of matter, the method comprising mixing, within a first mixing step, rubber, silica, and silica coupling agent to form a first masterbatch composition, adding nicotinamide to the first masterbatch composition and mixing within a second mixing step to form a second masterbatch composition, and adding a curative to the second masterbatch composition and ...
Nicotinamide adenine dinucleotide indicators, methods of preparation and application thereof
East China University Of Science And Technology
August 03, 2017 - N°20170219584

The invention relates to a genetically encoded fluorescent sensor for nicotinamide adenine dinucleotide, as well as methods of preparation and uses thereof. In one aspect, this invention relates to a sensor for detecting nicotinamide adenine dinucleotide, particularly, a recombinant fluorescent fusion protein sensor for detecting nicotinamide adenine dinucleotide. In one specific aspect, this invention relates to a recombinant fluorescent fusion ...
Crystalline form of nicotinamide riboside
W. R. Grace & Co.-conn.
July 27, 2017 - N°20170210774

Provided are crystalline forms of nicotinamide riboside, including a form i of nicotinamide riboside chloride according to formula (i). Also disclosed are pharmaceutical compositions comprising the crystalline form i of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions. In other aspects, the present disclosure pertains to methods comprising administering to a subject the crystalline form i of nicotinamide ...
Preparation and use of crystalline beta-d-nicotinamide riboside
Glaxosmithkline Intellectual Property (no.2) Limited
July 20, 2017 - N°20170204131

Provided herein are crystalline beta-d-nicotinamide riboside chloride compositions and methods of preparation and use thereof. Also provided are related pharmaceutical compositions and methods of use thereof. The crystalline beta-d-nicotinamide riboside chloride compositions may be used to treat a disease or disorder that would benefit from increased nad levels including a mitochondrial disease or disorder, insulin resistance, a metabolic syndrome, diabetes, ...
4,5-dihydroisoxazole derivatives as nampt inhibitors
Aurigene Discovery Technologies Limited
July 20, 2017 - N°20170204092

The present invention provides 4,5-dihydroisoxazole derivatives of formula (i), which may be therapeutically useful, more particularly as nampt inhibitors. Wherein, ring a, l1, l2, x1, x2, x3, z, r1, r2, r3, r4, r5, m, n, p and q have the meanings given in the specification and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases ...
Compositions and methods for treating hyperproliferative epidermal diseases
Dermipsor Ltd.
July 13, 2017 - N°20170196897

The present invention provides compositions and methods for use in the treatment of hyperproliferative dermal diseases. Specifically, the present invention teaches pharmaceutical compositions for topical administration that include a vitamin d metabolite, calcipotriol, and nicotinamide in a combination that is particularly effective in treating and in the maintenance therapy of psoriasis and other related dermal disorders and diseases.
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