This page is updated frequently with new Neurological-related patent applications.
|Data encryption/decryption using neurological fingerprints|
In accordance with one embodiment, a method for securing data is disclosed. The method includes sensing multi-dimensional motion of a body part of a user to generate a multi-dimensional signal; in response to the multi-dimensional signal and user calibration parameters, generating a neuro-mechanical fingerprint; and encrypting data with an encryption algorithm using the neuro-mechanical fingerprint as a key..
Aerendir Mobile Inc.
|Magnesium compositions and uses thereof for neurological disorders|
A composition for administration to a subject, such as oral administration to a subject, for example, has been provided. Such a composition may comprise at least one magnesium-counter ion compound.
|Nanoparticulate complex of nicotine and cerium oxide and use thereof|
Disclosed are particles comprising a complex of nicotine and cerium oxide and a biodegradable coating comprising agglutinin. Also disclosed is a method of treating or preventing neurodegenerative or neurological disorders in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of the particles..
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
|Device for interacting with neurological tissue and methods of making and using the same|
Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins.
Aleva Neurotherapeutics Sa
|Method for enriching cns-derived exosomes|
The application relates to a method for enriching cns-derived exosomes from a biological fluid such as blood, serum, plasma, or saliva. The method comprises: contacting a biological fluid containing cns-derived exosomes with an anti-l1cam antibody to form an immunocomplex, binding cns-derived exosomes in the biological fluid to a solid phase through the immunocomplex; and separating the solid phase bound exosomes from the biological fluid to enrich the cns-derived exosomes.
Xy Evergreen Technology Company
|Bispecific antibody fragments for neurological disease proteins and methods of use|
The present invention relates to therapeutic agents comprising bispecific recombinant antibody fragments to selectively clear a protein associated with a neurological disease and methods of use of these therapeutic agents to treat neurological diseases.. .
Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of
|Tetrahydroprotoberbine compounds and uses thereof in the treatment of neurological, psychiatric and neurodegenerative diseases|
Tetrahydroprotoberbine (thpb) compounds and their use in the treatment of neurological, psychiatric and neurodegenerative diseases is provided. The compounds include d-govadine, l-govadine and racemic govadine, as well as d-thpbs of general formula (i).
|Novel compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same|
The present invention relates to novel compounds having histone deacetylase 6 (hdac6) inhibitory activity, isomers thereof, or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions comprising the same, a method of treating disease using the composition, and methods for preparing the novel compounds. The novel compounds according to the present invention have histone deacetylase 6 (hdac6) inhibitory activity, and are effective for the prevention or treatment of hdac6-associated diseases, including cancer, inflammatory diseases, autoimmune diseases, neurological diseases and neurodegenerative disorders..
Chong Kun Dang Pharmaceutical Corp.
|Compositions for an injectable, in situ forming neuroscaffold and methods of using the same|
Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-d structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder..
|Engineered light-activated anion channel proteins and methods of use thereof|
Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells.
The Board Of Trustees Of The Leland Stanford Junior University
Combination of xenon and an antioxidant to control a parkinson's disease-type neurodegenerative disease
The invention relates to a drug combination including xenon gas and at least one antioxidant, in liquid or solid form, for use in treating, slowing, or preventing neurological damage following a neurodegenerative disease in a human being. Preferably, the xenon content is 10% to 80% by volume.
L'institut Du Cerveau Et De La Moelle Epiniere
Combination therapy with glutaminase inhibitors and immuno-oncology agents
The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an immuno-oncology therapeutic agent, such as an inhibitor of arginase, ctla-4, indoleamine 2,3-dioxygenase, and/or pd-1/pd-l1.. .
Calithera Biosciences, Inc.
System for variably configurable, adaptable electrode arrays and effectuating software
Electrical non-invasive brain stimulation (nibs) delivers weak electrical currents to the brain via electrodes that are affixed to the scalp. Nibs can excite or inhibit the brain in areas that are impacted by that electrical current during and for a short time following stimulation.
Rio Grande Neurosciences, Inc.
Methods of treating neurodevelopmental diseases and disorders
The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of trans 10-hda. In particular, the methods of the present invention are useful in the treatment and/or prophylaxis of acquired or progressive neurodevelopmental disorders and conditions in mammals.
The Florey Institute Of Neuroscience And Mental Health
Nanostructures for modulating intercellular communication and uses thereof
Nanostructures, compositions and methods for treating vesicle-related or exosome-related conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers, neurological disorders, rheumatologic disorders, viral disorders or other diseases or conditions at least in part by regulating vesicle uptake.
Pyrazolopyridine derivatives as modulators of tnf activity
A series of substituted pyrazolo[1,5-a]pyridine derivatives, being potent modulators of human tnfα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. .
Ucb Biopharma Sprl
Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
The disclosure relates to prostaglandin receptor ep2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which ep2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof..
Novel kcnq potassium channel agonists, preparation and use thereof
The present invention provides a compound represented by general formula i or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with rtg.
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
Cysteine, n-acetylcysteine, and penicillamine related compounds, pharmaceutical compositions thereof, and methods of use
Cysteine, n-acetylcysteine, and penicillamine related compounds, pharmaceutical compositions comprising the cysteine, n-acetylcysteine, and penicillamine related compounds, and methods of using cysteine, n-acetylcysteine, and penicillamine related compounds and pharmaceutical compositions thereof for treating liver, kidney, lung, neurological, inflammatory, and autoimmune disorders including paracetamol overdose, non-alcoholic steatohepatitis, wilson's disease, cystinuria, irritable bowel disorder, ulcerative colitis, rheumatoid arthritis, chronic obstructive pulmonary disease, interstitial lung disease, asthma, cystic fibrosis, parkinson's disease, and huntington's disease.. .
Cysteamine prodrugs, pharmaceutical compositions thereof, and methods of use
Cysteamine prodrugs, pharmaceutical compositions comprising the cysteamine prodrugs, and methods of using cysteamine prodrugs and pharmaceutical compositions thereof for treating eye, kidney, liver, metabolic, and neurological disorders such as cystinosis, cystinuria, non-alcoholic steatohepatitis, batten disease, leigh syndrome, and huntington's disease.. .
Device for interacting with neurological tissue and methods of making and using the same
Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts.
Ecole Polytechnique Federale De Lausanne
Delivery of antibodies to the central nervous system
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptide derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides.
Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders
Thyroid hormone antagonists and their nanoparticle formulations (nanotetrac™ or nanotriac™) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. The complex anti-angiogenic performs actions on specific cytokines and chemokines.
Methods and kits for treating and classifying individuals
The present disclosure provides methods and kits for treating and classifying individuals at risk of or suffering from a neurological and/or mitochondrial dysfunction or disorder. In general, the individuals are treated and/or classified based on the presence of a loss-of-function mutation in nuclear dna encoding one or more proteins selected from the group consisting of aldh1l1, aldh1l2, folr1, fpgs, gcsh, gldc, mthfd1, mthfd1l, mthfd2, mthfd2l, mthfs, mtrr, shmt1, shmt2 and slc25a32.
Courtagen Life Sciences, Inc.
Antagonists of slc38a9 and their use in therapy
The present invention relates to an antagonist or modulator of slc38a9 for use in treating a disease associated with mtorc1 activation, like a proliferative disease (e.g. A cancerous disease or benign proliferative disease), a metabolic disorder, a disorder of the immune system, a disorder causing premature aging, an ophthalmic disorder or a neurological disorder.
Cemm - Forschungzentrum Fuer Molekulare Medizin Gmbh
Egfr targeted therapy of neurological disorders and pain
The present invention relates to compositions and methods for treatment of neurological disorders. In particular, the present invention relates to the epidermal growth factor receptor (egfr) as a clinical target for treatment of neurological disorders, preferably in conjunction with neuropathic pain.
Sykehuset Sørlandet Hf
Suprametallogels and uses thereof
The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., pd(ii)-, ni(ii)-, or fe(ii)-ligand of formula (a)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers y.
Massachusetts Institute Of Technology
Methods of using sustained release aminopyridine compositions
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition..
Acorda Therapeutics, Inc.
Electronic catheter stethoscope
An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in a patient's urologic, digestive, reproductive, cardiovascular, neurological or pulmonary system. Measurement transducers are installed in a housing connectable to multiple preselected medical catheters.
The Charles Stark Draper Laboratory, Inc.
Compositions and methods utilizing lysophosphatidylcholine scaffolds
The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for lpc-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses.
National University Of Singapore
Methods for treating immune mediated neurological diseases
Polypeptides and other compounds that can bind specifically to the ch2-ch3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit fc-mediated immune complex formation, immune complexed igg to igg fγr binding, and immune complexed igg mc1q (membrane c1q) or soluble c1q binding. Such compounds may have therapeutic use in treating amyotrophic lateral sclerosis (als), parkinson's disease (pd), and alzheimer's disease (ad)..
Trinity Therapeutics, Inc.
Composition for use in treating and/or preventing human condition, disorder or diseases
Composition comprising a metal and/or a semimetal, a sodium salt, a tranquilizer, a halogen, a carotenoid, grain, and a neutral gel for example for use in treating and/or preventing a condition, disorder or disease such as pain, metabolic diseases, fatigue, absence of appetite, cramps, immune diseases, inflammatory disease, cancer, neurological and/or psychiatric diseases.. .
Pharmaceutically Acceptable Salt
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