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Neoplasm

Neoplasm-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Amino-substituted isoxazoles
Bayer Pharma Aktiengesellschaft
August 03, 2017 - N°20170217946

The present invention relates to amino-substituted isoxazoles of general formula (i): in which a, r1 and r2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment ...
Method of diagnosing neoplasms
Commonwealth Scientific And Industrial Research Organisation
July 27, 2017 - N°20170211152

The present invention relates generally to nucleic acid molecules, the rna and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine ...
Methods for providing personalized medicine test ex vivo for hematological neoplasms
Vivia Biotech, S.l.
July 20, 2017 - N°20170205395

Described herein are methods, devices, and compositions for providing personalized medicine tests for hematological neoplasms. In some embodiments, the methods comprise measuring the efficacy of inducing apoptosis selectively in malignant cells using any number of potential alternative combination drug treatments. In some embodiments, the ex vivo testing is measured using a recently extracted patient hematological samples. In other embodiments, the ...
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Benzimidazol-2-amines as midh1 inhibitors
Bayer Pharma Aktiengesellschaft
July 13, 2017 - N°20170197922

The present invention relates to benzimidazol-2-amines of general formula (i): in which r1, r2, r3, r4, r5, r6, r7, r8, r9, r10, r11 and r12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for ...
Benzimidazol-2-amines as midh1 inhibitors
Bayer Pharma Aktiengesellschaft
July 13, 2017 - N°20170197921

The present invention relates to benzimidazol-2-amines of general formula (i), in which r1, r2, r3, r4, r5, r6, r7, r8, r9, r10, r11 and r12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for ...
Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using ...
New York University School Of Medicine
July 13, 2017 - N°20170196494

The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not ...
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Methods of inhibiting pathological angiogenesis with doppel-targeting molecules
Pharsogen
June 29, 2017 - N°20170183416

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (pah), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.
Inhibitors of cyclin-dependent kinase 7 (cdk7)
Syros Pharmaceuticals, Inc.
June 29, 2017 - N°20170183355

The present invention provides novel compounds of formula (i) and formula (ii) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e. G., cancers (e. G., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and ...
Selective inhibitors interfering with fibroblast growth factor receptor and frs2 interaction for the prevention and ...
Limited Liability Company "russian Pharmaceutical Technologies"
June 29, 2017 - N°20170183315

The present technology relates to medicine and includes the use of inhibitors which selectively interfere with the interaction between a fibroblast growth factor receptor and frs2, and with the interaction with other components of the frs2 complex. Use of the selective inhibitors described in the present technology leads to a proven increase in anti-tumor efficacy relative to other inhibitors and ...
Inhibitors of cyclin-dependent kinase 7 (cdk7)
Syros Pharmaceuticals, Inc.
June 22, 2017 - N°20170174692

The present invention provides novel compounds described herein, such as of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e. G., cancers (e. G., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, ...
Nanoparticle-mediated ablation of glioblastoma and of other malignancies
Nanoprobes, Inc.
June 22, 2017 - N°20170173364

We disclose methods of treating cranial neoplasm using nanoparticles that are administered to the patient's brain. Our nanoparticles are novel, designed and synthesized explicitly to ensure their preferential accumulation in all parts of most brains that have remained with latent glioblastoma cells immediately after any primary neurosurgical debulking, and little or no accumulation in other parts of the brain.
Method to visualize very early stage neoplasm or other lesions
Nanoprobes, Inc.
June 22, 2017 - N°20170173191

A method for evaluating treatment outcome in a patient having a genetic predisposition for a malignant neoplasm before clinical manifestation of the neoplasm can be seen radiographically. The method permits visualization of any tumor, whether located externally on a patient's body or located internally in the body, and as small as 2 mm in diameter, using a biomarker. The method uses ...
Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
Nanoprobes, Inc.
May 25, 2017 - N°20170146541

The present invention relates to diagnostic, prognostic and clinical methods of distinguishing high-risk ipmn from more benign ipmn as well as high-grade panin and pdac from low-grade panin with moderate sensitivity and very high specificity using das-1 and related antibodies.
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Urea derivatives and uses thereof
Kala Pharmaceuticals, Inc.
May 11, 2017 - N°20170129876

The present invention provides novel compounds of any one of formulae (i)-(iii), and pharmaceutical compositions thereof. Also provided are particles (e. G., nanoparticles) comprising compounds of formula (i)-(iii) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or ...
Prolactin receptor antagonists for treatment of glioblastoma
Prorec Bio Ab
May 11, 2017 - N°20170128527

The present inventor has found that glioblastoma cells respond in unique ways to prolactin (prl) receptor antagonists. The reaction of glioblastoma cells to treatment with prl receptor antagonists is based on the presence and function of prl receptors in glioblastomas and the activity can be used for treatment of glioblastomas and other neoplasms of the cns.
Combination therapy using ribavirin as eif4e inhibitor
Universite De Montreal
May 04, 2017 - N°20170119809

The present invention relates to pharmaceutical compositions and combination therapies for treating patients having a neoplasm or a proliferative disorder, the combination comprises an inhibitor of the eif4e gene product and a chemotherapeutic agent, wherein said combination therapy overcomes resistance developed in patients during anti-neoplastic treatment. The present invention also provides for the use of a combination therapy for ...
Methods and materials for detecting gene amplification
Mayo Foundation For Medical Education And Research
April 06, 2017 - N°20170096715

This document relates to methods and materials involved in detecting gene amplification in a mammal. For example, methods and materials for detecting amplification at cpm and mdm2 loci to determine the presence or absence of a malignant lipomatous neoplasm in a mammal are provided.
Detecting colorectal neoplasm
Exact Sciences Corporation
March 16, 2017 - N°20170073772

Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
Suprametallogels and uses thereof
Massachusetts Institute Of Technology
March 16, 2017 - N°20170073311

The disclosure provides nanostructures (e. G., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e. G., pd(ii)-, ni(ii)-, or fe(ii)-ligand of formula (a)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers y. The provided supramolecular complexes are able to form gels (e. G., hydrogels). The ...
Detecting gastric neoplasm
Exact Sciences Corporation
March 02, 2017 - N°20170058356

Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.
Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
Geron Corporation
February 23, 2017 - N°20170051287

Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have essential thrombocythemia (et). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having et.
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