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Neoplasm patents

      

This page is updated frequently with new Neoplasm-related patent applications.




 Novel peptidomimetics with antiangiogenic activity patent thumbnailNovel peptidomimetics with antiangiogenic activity
We disclose novel peptidomimetics with antiangiogenic activity and their uses, particularly in the treatment of neoplasms and chronic inflammation (in particular of: rheumatoid arthritis, colitis), in eczema, diabetes, age-related macular degeneration (armd), nephropathy and neuropathy, in particular for use in the form of intravenous infusions or injections, or implants releasing the active ingredient.. .
Uniwersytet Warszawski (heir Of The Deseased Inventor)


 Therapies for treating cancers patent thumbnailTherapies for treating cancers
Provided herein are methods, compositions, and kits for treating myeloproliferative disorders or neoplasms, including polycythemia vera, primary myelofibrosis, thrombocythemia, and essential thrombocythemia. Also provided herein are methods for treating cancers.
Gilead Sciences, Inc.


 4-dedimethylamino tetracycline compounds patent thumbnail4-dedimethylamino tetracycline compounds
The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression..
Paratek Pharmaceuticals, Inc.


 Salts and polymorphs of a tetracycline compound patent thumbnailSalts and polymorphs of a tetracycline compound
Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general..
Paratek Pharmaceuticals, Inc.


 Tet2 as a diagnostic and pronostic marker in hematopoietic neoplasms patent thumbnailTet2 as a diagnostic and pronostic marker in hematopoietic neoplasms
The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the ten eleven translocation protein family member 2 gene (tet2) coding for the polypeptide having the sequence seq id no: 2, and/or (ii) analyzing the expression of the tet2 gene; wherein the detection of such a tet2 mutation, of the absence of expression of tet2 or of the expression of a truncated tet2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.. .
Universite Paris-sud


 Methods to treat lymphoplasmacytic lymphoma patent thumbnailMethods to treat lymphoplasmacytic lymphoma
The present invention provides compounds of any one of formulae (a), (i-11), (ii), and (v) (e.g., compounds of formula (a-1)-(a-18)), and methods for treating waldenström's macroglobulinemia (wm) and other b cell neoplasm in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds.
Dana-farber Cancer Institute, Inc.


 Methods to treat lymphoplasmacytic lymphoma patent thumbnailMethods to treat lymphoplasmacytic lymphoma
The present invention provides compounds of any one of formulae (i) to (v) (e.g., compounds of any one of formulae (i-1) to (i-9)), and methods for treating waldenström's macroglobulinemia (wm) and other b cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds.
Dana-farber Cancer Institute, Inc.


 Detecting neoplasm patent thumbnailDetecting neoplasm
This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided..
Mayo Foundation For Medical Education And Research


 Cancer treatment using viruses and camptothecins patent thumbnailCancer treatment using viruses and camptothecins
Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a sindbis virus, a picornavirus, and a myxoma virus.
Wellstat Biologics Corporation


 Crystalline forms of ponatinib hydrochloride patent thumbnailCrystalline forms of ponatinib hydrochloride
The present disclosure relates to polymorphic forms of the hydrochloride salt of ponatinib (“compound 1”) and to processes for the preparation of these polymorphic forms. The present disclosure also generally relates to a pharmaceutical composition comprising the forms, as well of methods of using the form(s) in the treatment of disorders associated with pathological cellular proliferation, such as neoplasms, and cancer..
Sandoz Ag


Therapies for treating myeloproliferative disorders

Provided herein are methods, compositions, and kits for treating myeloproliferative disorders or neoplasms, including polycythemia vera, primary myelofibrosis, thrombocythemia, and essential thrombocythemia.. .
Gilead Sciences, Inc.

Use of novel anti-hpv pharmaceutical preparation

The invention discloses a use of paracetamol and a pharmaceutical preparation containing the same in preparation of anti-hpv drugs. The novel anti-hpv pharmaceutical preparation of the invention has a significant anti-hpv effect and low toxicity, and can be used for preventing and treating clinical symptoms caused by hpv infection, especially common warts, plane warts, plantar wart, vulvar cancer, penile neoplasms, anal carcinoma, prostate cancer, bladder cancer, cervical cancer, rectal cancer, oral cancer, tonsil cancer and the like..
Institute Of Biomedical Engineering Chinese

Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)

The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Dana-farber Cancer Institute, Inc.

Heteromaromatic compounds useful for the treatment of prolferative diseases

The present invention provides novel compounds of formula (i) and formula (ii), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Syros Pharmaceuticals, Inc.

Heteroaromatic compounds useful for the treatment of prolferative diseases

The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Dana-farber Cancer Institute, Inc.

Monitoring health and disease status using clonotype profiles

There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using dna sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions.
Adaptive Biotechnologies Corp.

Detecting gastrointestinal neoplasms

Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).. .
Mayo Foundation For Medical Education And Research

Compounds suitable for the treatment of myeloproliferative neoplasms as well as methods for the diagnosis/prognosis of myeloproliferative neoplasms

The present findings point to mutant hscs as the cause of bm neuroglial damage that compromises msc survival and function, critically contributing to mpn pathogenesis. In this sense, the present invention shows that the niche damage triggered by the mutant hsc is essential for the development of a haematopoietic malignancy previously considered to be caused by the hsc alone.
Cnic Fundacion Centro Nacional De Investigaciones Cardiovasculares Carlos Iii

Near-infrared fluorescent surgical dye markers

The potential use of a pmma encapsulated near-infrared fluorescent dye includes endoscopic tattooing of intestinal neoplasms, location visualization of non-palpable breast lesions, and, but not limited to, location/visualization of soft tissue lesions in difficult anatomic regions. Commercially available fluorescent imaging systems, both open and laparoscopic, would be used in conjunction to fluoresce these marked tissues, augmenting the surgeon's ability to intraoperatively locate the correct lesion to resect..

Partial peptide of survivin presented on mhc class ii molecule and use thereof

The object aims to provide: a novel tumor antigen; a novel therapeutic agent useful in a method for treating a malignant neoplasm by utilizing the tumor antigen; and a tumor antigen which can be used as the therapeutic agent. Thus, disclosed are: a novel tumor antigen which has an epitope capable of inducing a th1 cell which is a cd4-positive t cell specific to survivin; and use of the tumor antigen.
Tella, Inc.

Hydroxyalkyl starch for the treatment of hematological neoplasms

The present invention relates to hydroxyalkyl starch or a pharmaceutical preparation thereof for the treatment of a hematological neoplasm, especially by effectively reducing proliferation rate of cancer cells and inhibiting cancer cell growth and wherein the hydroxyalkyl starch has a mean molecular weight (mw) above 20 and below 1300 kda and a molar substitution (ms) in the range of from 0.1 to 1.5, wherein the alkylation may be an ethylation, propylation or butylation or mixes thereof; and wherein the alkyl may be further substituted.. .

Pim kinase inhibitor combinations

The present invention relates to a pim kinase inhibitor compound that can be used alone or in a pharmaceutical combination. One such combination comprises (a) a jak inhibitor compound, (b) a pim kinase inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of a myeloid neoplasm or leukemia; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of myeloid neoplasm or leukemia; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a mammal, especially a human..

Personalized protease assay to measure protease activity in neoplasms

Disclosed herein, the invention pertains to methods and compositions that find use in diagnostic, prognostic and characterization of neoplasia samples based on the ability of a neoplasia sample to cleave a mts molecule of the present invention. In some embodiments, a mts molecule disclosed herein has the formula (a-x-b-c), wherein a is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; b is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; x is a linker; and c is a detectable moiety..
The Regents Of The University Of California

Method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm

The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression of cavcolin-1, cavcolin-2, vimentin, calponon2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, ef-i-delta, or m2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.. .
Thomas Jefferson University

Novel compounds and uses thereof

The present invention provides novel compounds of any one of formulae (i)-(iv), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of any one of formulae (i)-(iv) and pharmaceutical compositions thereof that are mucus penetrating.
Kala Pharmaceuticals, Inc.

Determining tumor load and biallelic mutation in patients with calr mutation using peripheral blood plasma

Compositions and fragment length analysis methods are provided for detecting calr mutations and determining tumor load in patients with myeloproliferative neoplasms.. .
Neogenomics Laboratories, Inc.

Method of diagnosing neoplasms

The present invention relates generally to a nucleic acid molecule, the rna and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a large intestine neoplasm. More particularly, the present invention is directed to a nucleic acid molecule, the expression profiles of which are indicative of the onset and/or progression of a colorectal neoplasm, such as an adenoma or an adenocarcinoma.
Commonwealth Scientific And Industrial Research Organisation

Methods for assaying jak2 activity in red blood cells and uses thereof

The present invention relates to methods for assaying jak2 activity in a red blood cell. The present invention also relates to methods for diagnosing myeloproliferative neoplasm..
Universite Des Antilles Et De La Guyane

Anti-cs1 antibodies and antibody drug conjugates

The present disclosure provides antibodies and antibody drug conjugates that bind human cs1 and their uses to treat subjects diagnosed with a plasma cell neoplasm, for example, multiple myeloma.. .
Abbvie Biotherapeutics Inc.

Inhibitors of cyclin-dependent kinase 7 (cdk7)

The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Dana-farber Cancer Institute, Inc.

Modulators of adp-dependent glucokinase (adpgk) and glycerol-3-phosphate dehydrogenase (gpd2) for therapy

Described are compounds capable of modulating (a) the biological activity of adp-dependent glucokinase (adpgk) and/or glycerol-3-phosphate dehydrogenase (gpd2) or (b) the expression of the gene encoding adpgk or gpd2 for use in treating a disease (a) associated with aberrant cell proliferation, e.g., a neoplasm, or (b) of the immune system, e.g., an autoimmune disease.. .
Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Recht

Detecting cholangiocarcinoma

Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarinoma.. .
Mayo Foundation For Medical Education And Research



Neoplasm topics:
  • Autoimmune Disease
  • Autoimmune
  • Immune Disease
  • Neurotoxin
  • Graft Versus Host Disease
  • Botulinum Toxin
  • Modulation
  • Human Papillomavirus
  • Antibodies
  • Ascorbic Acid
  • Neoplastic
  • Proliferative
  • Epithelial
  • Neuroblastoma
  • Osteosarcoma


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    This listing is a sample listing of patent applications related to Neoplasm for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Neoplasm with additional patents listed. Browse our RSS directory or Search for other possible listings.


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