Neoplasm

Neoplasm-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity
The University Of North Carolina At Chapel Hill
May 18, 2017 - N°20170136043

Uses of pyrrolopyrimidines with anti-mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against mertk−/− tumors and itd and tkd mutant forms of acute myeloid leukemia (aml)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
Urea derivatives and uses thereof
Kala Pharmaceuticals, Inc.
May 11, 2017 - N°20170129876

The present invention provides novel compounds of any one of formulae (i)-(iii), and pharmaceutical compositions thereof. Also provided are particles (e. G., nanoparticles) comprising compounds of formula (i)-(iii) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or ...
Prolactin receptor antagonists for treatment of glioblastoma
Prorec Bio Ab
May 11, 2017 - N°20170128527

The present inventor has found that glioblastoma cells respond in unique ways to prolactin (prl) receptor antagonists. The reaction of glioblastoma cells to treatment with prl receptor antagonists is based on the presence and function of prl receptors in glioblastomas and the activity can be used for treatment of glioblastomas and other neoplasms of the cns.
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Methods and materials for detecting gene amplification
Mayo Foundation For Medical Education And Research
April 06, 2017 - N°20170096715

This document relates to methods and materials involved in detecting gene amplification in a mammal. For example, methods and materials for detecting amplification at cpm and mdm2 loci to determine the presence or absence of a malignant lipomatous neoplasm in a mammal are provided.
Detecting colorectal neoplasm
Exact Sciences Corporation
March 16, 2017 - N°20170073772

Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
Suprametallogels and uses thereof
Massachusetts Institute Of Technology
March 16, 2017 - N°20170073311

The disclosure provides nanostructures (e. G., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e. G., pd(ii)-, ni(ii)-, or fe(ii)-ligand of formula (a)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers y. The provided supramolecular complexes are able to form gels (e. G., hydrogels). The ...
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Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
Geron Corporation
February 23, 2017 - N°20170051287

Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have essential thrombocythemia (et). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having et.
Methods and compositions for single chain variable region enox2 antibodies for cancer detection and diagnosis
Mor-nuco Enterprises, Inc.
February 02, 2017 - N°20170030919

Cancers of different cellular or tissue origins express different enox2 cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of ...
Methods for single chain variable region enox2 antibodies for cancer detection and diagnosis
Mor-nuco Enterprises, Inc.
February 02, 2017 - N°20170030918

Cancers of different cellular or tissue origins express different enox2 cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of ...
Amido-substituted azole compounds
Bayer Pharma Aktiengesellschaft
January 26, 2017 - N°20170020886

The present invention relates to amido-substituted azole compounds of general formula (i), in which x1, x2, r1, r2, r4, r5, r7 and r8 are as defined in the claims which are inhibitors of tnks1 and/or tnks2, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and ...
System and method of measuring efficacy of cancer therapeutics
Mousera, Inc
January 05, 2017 - N°20170000906

The field of this invention is measuring efficacy of cancer treatments. In particular the fields of this invention include studies of drug efficacy, use of animals in medical studies, use of animals in vivariums, and use of rodents, particularly mice. Cells from a neoplasm are injected into subject test animals in a specific organ or a specific location of a ...
Combination therapy comprising an inhibitor of jak, cdk, and pim
Novartis Ag
December 29, 2016 - N°20160375024

The present invention relates to a pharmaceutical combination which comprises (a) a jak inhibitor compound, (b) a cdk inhibitor, and (c) a pim kinase inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of a myeloid neoplasm or leukemia; a pharmaceutical composition comprising such a combination; the use ...
Method for diagnosing, quantifying, treating, monitoring or evaluating conditions, diseases or disorders associated with human ...
Novartis Ag
December 22, 2016 - N°20160369357

A method of diagnosing, quantifying, treating, monitoring or evaluating a condition in a subject is provided. The method comprises obtaining a sample from the subject, detecting and determining the presence or quantity of one or more than one human papilloma virus (hpv) in the sample, wherein the presence or quantity of the one or more than one hpv is indicative ...
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Novel peptidomimetics with antiangiogenic activity
Uniwersytet Warszawski (heir Of The Deseased Inventor)
November 17, 2016 - N°20160333047

We disclose novel peptidomimetics with antiangiogenic activity and their uses, particularly in the treatment of neoplasms and chronic inflammation (in particular of: rheumatoid arthritis, colitis), in eczema, diabetes, age-related macular degeneration (armd), nephropathy and neuropathy, in particular for use in the form of intravenous infusions or injections, or implants releasing the active ingredient.
Therapies for treating cancers
Gilead Sciences, Inc.
November 17, 2016 - N°20160331754

Provided herein are methods, compositions, and kits for treating myeloproliferative disorders or neoplasms, including polycythemia vera, primary myelofibrosis, thrombocythemia, and essential thrombocythemia. Also provided herein are methods for treating cancers. Such methods may include the use of a jak inhibitor and a pi3k inhibitor. Such methods may include the use of an anti-cd20 antibody and a pi3k inhibitor. ...
4-dedimethylamino tetracycline compounds
Paratek Pharmaceuticals, Inc.
November 10, 2016 - N°20160324880

The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
Salts and polymorphs of a tetracycline compound
Paratek Pharmaceuticals, Inc.
November 10, 2016 - N°20160324879

Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
Tet2 as a diagnostic and pronostic marker in hematopoietic neoplasms
Universite Paris-sud
November 03, 2016 - N°20160319370

The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the ten eleven translocation protein family member 2 gene (tet2) coding for the polypeptide having the sequence seq id no: 2, ...
Methods to treat lymphoplasmacytic lymphoma
Dana-farber Cancer Institute, Inc.
November 03, 2016 - N°20160318878

The present invention provides compounds of any one of formulae (a), (i-11), (ii), and (v) (e. G., compounds of formula (a-1)-(a-18)), and methods for treating waldenström's macroglobulinemia (wm) and other b cell neoplasm in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also ...
Methods to treat lymphoplasmacytic lymphoma
Dana-farber Cancer Institute, Inc.
October 27, 2016 - N°20160311807

The present invention provides compounds of any one of formulae (i) to (v) (e. G., compounds of any one of formulae (i-1) to (i-9)), and methods for treating waldenström's macroglobulinemia (wm) and other b cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. ...
Detecting neoplasm
Mayo Foundation For Medical Education And Research
October 20, 2016 - N°20160305946

This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.