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|| List of recent Neoplasm-related patents
|Smoothened polypeptides and methods of use|
Disclosed is an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a smoothened (smo) protein, wherein the portion comprises an amino acid sequence of any of the intracellular loops of the smo protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment, wherein the functional fragment comprises at least 7 contiguous amino acids of the intracellular loops, and wherein the functional fragment or functional variant inhibits proliferation of a diseased cell, or a fatty acid derivative thereof. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided.
|Methods for the treatment of skin neoplasms|
Methods of treating skin neoplasms using a monoamine oxidase inhibitor, e.g., a propynylaminoindan (such as rasagiline) are provided. Pharmaceutical compositions and kits comprising monoamine oxidase inhibitors are also provided..
|Use of antibodies against nk1, nk2 and/or nk3 receptors in cancer treatment|
The object of this invention is the use of an antibody or a fragment thereof specific against nk1, nk2 and/or nk3 receptors of cells, for the manufacture of a medicament for the therapeutic management of human cancer, by direct administration to a mammal, including humans, by inducing cell death or apoptosis of tumour cells, modification of peritumoural microenvironment (consisting of stromal cells, stromal matrix, and intra and peritumoural vascularisation) and/or inflammatory and/or immune response around the tumour. In particular, in the case of melanoma, carcinoma (specially, breast carcinoma, lung, digestive system, prostate, cervix, endometrium, ovary and bladder), leukaemia, lymphomas, neoplasms, such as neuroblastoma and sarcoma, such as osteosarcoma..
|Assessing thyroid neoplasms|
This document provides methods and materials involved in assessing thyroid neoplasms. For example, methods and materials for using microrna (mir) levels (e.g., mir122 levels) to determine whether a thyroid neoplasm (e.g., a follicular thyroid neoplasm) is benign or malignant as well as methods and materials for using mir levels (e.g., mir122 levels) to determine whether a malignant thyroid cancer patient is likely to have a favorable or unfavorable outcome are provided.
|Treating neoplasms with neurotoxin|
The present invention provides a method of treating a cancer using a neurotoxin, preferably botulinum toxin (“btx”). The application of a neurotoxin around a cancer acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze cancer cells through efferent channels leaving the cancer vicinity to distant sites.
|Therapeutic agent, composition including said agent, implantable device and process for the treatment of cervical cancer and/or for the prevention of the formation of neoplasms in correspondence of the cervix in a human female genital system|
A medical composition including a chemotherapeutic medication or a targeted therapy medication is used in a human female patient for the treatment of a disease selected in the group comprising cervical cancer, cervical intraepithelial neoplasia (cin), human papillomavirus (hpv) infection of the female genital system; the chemotherapeutic agent or targeted therapy medication is locally delivered directly to cervix of a female genital system by an implanted medical device including a stem to be implanted in the cervix. The stem has a drug carrying layer including the medical composition.
|Determination of cancer predisposition|
Disclosed herein are systems and methods for using demethylation of genomic dna for diagnosing, predicting, and/or monitoring the status or outcome of a neoplasm or a cancer in a subject.. .
|Combinatory cancer treatment|
The present invention relates to a pharmaceutical composition for treating a neoplasm, a preneoplasm, a proliferative disorder and/or a precancerous lesion, the use of such compositions for the treatment of the listed conditions, and methods of treating the listed conditions. The composition of the present invention comprises an inhibitor of eif4e, a methltransferase inhibitor, and a pharmaceutically acceptable carrier..
|Egfr inhibitor and antiviral agent for simultaneous, separate or sequential use in the treatment and/or prevention and/or palliation of cancer|
The application relates to a combination of biologically active compounds comprising at least one antiviral agent and at least one egfr antagonist, for simultaneous, separate or sequential use in the treatment and/or prevention and/or palliation of malignant or pre-malignant neoplasms, preferably of solid malignant or pre-malignant neoplasms.. .
|Treating neoplasms with neurotoxin|
The present invention provides a method of treating a neoplasm using a neurotoxin, preferably botulinum toxin. Neurotoxin administered around a neoplasm acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze neoplastic cells through efferent channels leaving the neoplasm to distant sites.
|Compositions and methods for enhancing the effectiveness of systemic, hipec, ip, and related cancer treatments|
Methods for treating cancers, tumors, and neoplasms using a composition comprising one or more generally regarded as safe (gras) compounds selected from the group of components consisting of vitamins, selenium, fatty acids, fatty acid salts, and fatty acid esters, and mixtures of two or more said components, either as a stand-alone treatment or in combination with one or more anti-cancer drugs or devices or other anti-neoplastic agents, treatments, or devices are provided. In some instances, concomitant hyperthermia therapy is employed.
|Monitoring health and disease status using clonotype profiles|
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using dna sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions.
|Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma|
The present invention relates to diagnostic, prognostic and clinical methods of distinguishing high-risk ipmn from more benign ipmn as well as high-grade panin and pdac from low-grade panin with moderate sensitivity and very high specificity using das-1 and related antibodies.. .
|Composition possessing antioxidant, immonomodulated, and antitumorous action and method of treating neoplasms|
A composition produces antioxidant, immunomodulated, and antitumorous effects. The composition includes tannic acid, potassium iodide, and ascorbic acid.
|Gna11 and gnaq exon 4 mutations in melanoma|
The present invention provides methods of detecting activating mutations in exon 4 of a gnaq or a gna11 gene in a melanocytic neoplasm for diagnostic and prognostic purposes. The invention further provides methods of treating such melanocytic neoplasm by modulating the activity of the mutated gnaq or gna11..
|Methods of identifying patients with ovarian epithelial neoplasms based on high-resolution mass spectrometry|
Methods for identifying patients with ovarian neoplasms are provided herein comprising performing an assay step of detecting a metabolite in a serum sample of a patient where the metabolite is probably not produced by a tumor but could induce the development of a tumor, and the presence of the metabolite being indicative of an increased likelihood that the patient has ovarian cancer,. .
|Soluble mtor complexes and modulators thereof|
The present invention relates to small molecule modulators of mtorc1 and mtorc2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases.
|Asxl1 as a new diagnostic marker of myeloid neoplasms|
A method for diagnosing a myeloid cancer in a subject, includes the step of analyzing a biological sample from the subject by determining the presence or the absence of a mutation in the asxl1 (additional sex combs like 1) gene coding for the polypeptide having the sequence seq id n°2. A kit for diagnosing myeloid cancer in a subject including at least one nucleic acid probe or oligonucleotide or at least one antibody, which can be used in a such a method is also described..
|Gna11 mutations in melanoma|
The present invention provides methods of detecting mutations in a gna11 gene in a melanocytic neoplasm for diagnostic and prognostic purposes. The invention further provides methods of treating such melanocytic neoplasm by modulating the activity of the mutated gna11 gene..
|Adenocarcinoma specific antibody sam-6, and uses thereof|
The present invention features a polypeptide, such as an antibody produced by the hybridoma sam-6 and its use in the treatment and diagnosis of neoplasms.. .
|Novel water soluble furoxan derivatives having antitumor activity|
Water soluble compounds having a furoxan structure which are capable of inhibiting metabolic pathways involved in the development of the tumours are provided. The use of such compounds as a medicament in the therapy of the tumours and as an adjuvant in the immunotherapy protocols against neoplasms is also described..
|Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus|
The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents. The virus is preferably a reovirus..
|Methods and materials for detecting colorectal cancer and adenoma|
The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers (e.g., markers associated with colorectal cancer, markers associated with adenoma) in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having a colorectal neoplasm by detecting the presence and level of indicators of colorectal neoplasia such as, for example, long dna (e.g., quantified by alu pcr) and the presence and level of tumor-associated gene alterations (e.g., mutations in kras, apc, melanoma antigen gene, p53, braf, bat26, pik3ca) or epigenetic alterations (e.g., dna methylation) (e.g., cpg methylation) (e.g., cpg methylation in coding or regulatory regions of bmp-3, bmp-4, sfrp2, vimentin, septin9, alx4, eya4, tfpi2, ndrg4, foxe1) in dna from a stool sample obtained from the mammal..
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Neoplasm topics: Autoimmune Disease, Autoimmune, Immune Disease, Neurotoxin, Graft Versus Host Disease, Botulinum Toxin, Modulation, Human Papillomavirus, Antibodies, Ascorbic Acid, Neoplastic, Proliferative, Epithelial, Neuroblastoma, Osteosarcoma
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