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Neoplasm

Neoplasm-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods of increasing delivery of anti-cancer agents to targets
Oncoquest, Inc.
January 04, 2018 - N°20180002441

The present invention provides compositions and methods for increasing the permeability of a stroma around a neoplasm, and particularly to cancer cells associated with solid tumors. In one embodiment, combining a therapeutic ige antibody with an anti-cancer agent in accordance with the invention increases the delivery of the anticancer agent to the site of, for example, a solid tumor in ...
Rapid quantitative detection of single nucleotide polymorphisms or somatic variants and methods to identify malignant ...
The General Hospital Corporation
December 28, 2017 - N°20170369939

Provided are systems, kits, and methods for the quantitative detection of single nucleotide polymorphisms or variants to identify malignant neoplasms. The methods include use of modified oligonucleotide blockers with peptide nucleic acid backbones that hybridize to and block logarithmic amplification of the wild-type alleles of a target, and incorporation of locked nucleic acids into probes that are complementary to a ...
Pim kinase inhibitor combinations
Novartis Ag
December 28, 2017 - N°20170368044

The present invention relates to a pim kinase inhibitor compound that can be used alone or in a pharmaceutical combination. One such combination comprises (a) a jak inhibitor compound, (b) a pim kinase inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of a myeloid neoplasm or leukemia; ...
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Methods and compositions for single chain variable region enox2 antibodies for cancer detection and diagnosis
Mor-nuco Enterprises, Inc.
November 30, 2017 - N°20170343555

Cancers of different cellular or tissue origins express different enox2 cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of ...
Amino-substituted isothiazoles
Bayer Pharma Aktiengesellschaft
November 23, 2017 - N°20170334899

The present invention relates to amino-substituted isothiazoles of general formula (i): in which a, r1 and r2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment ...
Inhibitors of cyclin-dependent kinase 7 (cdk7)
November 16, 2017 - N°20170327496

The present invention provides novel compounds of formula (i) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e. G., cancers (e. G., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in ...
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1-cyclohexyl-2-phenylaminobenzimidazoles as midh1 inhibitors for the treatment of tumors
Bayer Pharma Aktiengesellschaft
November 09, 2017 - N°20170319549

The present invention relates to benzimidazol-2-amines of general formula (i) in which r1, r2, r3, r4, r5, r6, r7, r8, r9, r10, r11 and r12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for ...
Substituted tetracycline compounds
Paratek Pharmaceuticals, Inc.
October 26, 2017 - N°20170305840

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
Combinations for the treatment of neoplasms using quiescent cell targeting and inhibitors of mitosis
October 19, 2017 - N°20170296542

The present invention provides compositions and methods for the treatment of neoplasms, in particular, by targeting of quiescent cancer cells with therapeutic agents in combination with other treatments effective against certain neoplastic conditions, in particular, anti-cancer treatment with therapeutic agents that are inhibitors of mitosis (a mitotic inhibitor).
Combinations for the treatment of neoplasms using quiescent cell targeting with egfr inhibitors
October 19, 2017 - N°20170296541

The present invention provides compositions and methods for the treatment of neoplasms, in particular, by targeting of quiescent cancer cells with therapeutic agents in combination with other treatments effective against certain neoplastic conditions, in particular, anti-cancer treatment with egfr inhibitor agents.
Detection method
Commonwealth Scientific And Industrial Research Organisation
September 14, 2017 - N°20170260585

The present invention relates generally to an array of nucleic acid molecules, the expression profiles of which characterise the anatomical origin of a cell or population of cells within the large intestine. More particularly, the present invention relates to an array of nucleic acid molecules, the expression profiles of which characterise the proximal or distal origin of a cell or ...
Methods of inhibiting pathological angiogenesis with doppel-targeting molecules
Pharosgen
September 14, 2017 - N°20170260278

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (pah), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.
Compositions and methods of aloe polysaccharides
Bespoke Bioscience, Llc
August 31, 2017 - N°20170246199

The present invention describes a method for preparing a polymannan extract from freeze-dried aloe powder. The polymannan extract of the present invention is further used to formulate a sterile injectable formulation for the treatment of one or more cancers, leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, immune diseases, particularly immune related neoplasms, acquired immune deficiency syndrome, and ...
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Image analysis method supporting illness development prediction for a neoplasm in a human or animal ...
Stichting Maastricht Radiation Oncology
August 17, 2017 - N°20170236283

The present invention relates to an image analysis method for providing information for supporting illness development prediction regarding a neoplasm in a human or animal body. The method includes receiving for the neoplasm first and second image data at a first and second moment in time, and deriving for a plurality of image features a first and a second image ...
Compositions and methods for enhancing the effectiveness of systemic, hipec, ip, and related cancer treatments
Chemotherapeutics, Llc
August 17, 2017 - N°20170232037

Methods for treating cancers, tumors, and neoplasms using a composition comprising one or more generally regarded as safe (gras) compounds selected from the group of components consisting of vitamins, selenium, fatty acids, fatty acid salts, and fatty acid esters, and mixtures of two or more said components, either as a stand-alone treatment or in combination with one or more anti-cancer ...
Antineoplastic combinations containing hki-272 and vinorelbine
Wyeth Llc
August 17, 2017 - N°20170231972

A combination of hki-272 compound and a vinorelbine compound in the treatment of a neoplasm is provided. Regimens, kits, and method for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described.
Amino-substituted isoxazoles
Bayer Pharma Aktiengesellschaft
August 03, 2017 - N°20170217946

The present invention relates to amino-substituted isoxazoles of general formula (i): in which a, r1 and r2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment ...
Method of diagnosing neoplasms
Commonwealth Scientific And Industrial Research Organisation
July 27, 2017 - N°20170211152

The present invention relates generally to nucleic acid molecules, the rna and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine ...
Methods for providing personalized medicine test ex vivo for hematological neoplasms
Vivia Biotech, S.l.
July 20, 2017 - N°20170205395

Described herein are methods, devices, and compositions for providing personalized medicine tests for hematological neoplasms. In some embodiments, the methods comprise measuring the efficacy of inducing apoptosis selectively in malignant cells using any number of potential alternative combination drug treatments. In some embodiments, the ex vivo testing is measured using a recently extracted patient hematological samples. In other embodiments, the ...
Detecting neoplasm
Mayo Foundation For Medical Education And Research
July 13, 2017 - N°20170198361

This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
Benzimidazol-2-amines as midh1 inhibitors
Bayer Pharma Aktiengesellschaft
July 13, 2017 - N°20170197922

The present invention relates to benzimidazol-2-amines of general formula (i): in which r1, r2, r3, r4, r5, r6, r7, r8, r9, r10, r11 and r12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for ...
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