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Neoplasm patents



      
           
This page is updated frequently with new Neoplasm-related patent applications. Subscribe to the Neoplasm RSS feed to automatically get the update: related Neoplasm RSS feeds. RSS updates for this page: Neoplasm RSS RSS


Mutations in pancreatic neoplasms

Date/App# patent app List of recent Neoplasm-related patents
07/03/14
20140186376
 Compositions and methods for inhibiting ccl3 patent thumbnailCompositions and methods for inhibiting ccl3
The present invention relates to the discovery that ccl3, through at least one of its receptors ccr1 and ccr5, plays a role in the pathologies associated with myeloid neoplasms. In various embodiments, the pathologies associated with myeloid neoplasms treatable by the compositions and methods of the invention described herein include, but are not limited to, at least one of osteoclast/osteoblast imbalance, inhibition of osteoblast function, bone loss, disregulation of the hematopoietic stem cell microenvironment, abnormal hematopoietic recovery, pancytopenia, anemia, thrombocytopenia, neutropenia, bicytopenia, and erythrocytopenia.
06/26/14
20140179538
 Mutations in pancreatic neoplasms patent thumbnailMutations in pancreatic neoplasms
To help reveal the pathogenesis of these lesions, we purified the dna from intraductal papillary mucinous neoplasm (ipmn) cyst fluids from 19 patients and searched for mutations in 169 genes commonly altered in human cancers. We identified recurrent mutations at codon 201 of gnas.
06/19/14
20140171624
 Modulators of adp-dependent glucokinase (adpgk) and glycerol-3-phosphate dehydrogenase (gpd2) for therapy patent thumbnailModulators of adp-dependent glucokinase (adpgk) and glycerol-3-phosphate dehydrogenase (gpd2) for therapy
Described are compounds capable of modulating (a) the biological activity of adp-dependent glucokinase (adpgk) and/or glycerol-3-phosphate dehydrogenase (gpd2) or (b) the expression of the gene encoding adpgk or gpd2 for use in treating a disease (a) associated with aberrant cell proliferation, e.g., a neoplasm, or (b) of the immune system, e.g., an autoimmune disease.. .
06/19/14
20140171416
 Cephalotaxus esters, methods of synthesis, and uses thereof patent thumbnailCephalotaxus esters, methods of synthesis, and uses thereof
The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of using said compounds or compositions in the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease.
06/19/14
20140171384
 Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine patent thumbnailAntineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
A combination of a 4-anilino-3-cyanoquinoline compound (e.g. Hki-272, ski-606, ekb-569) and a capecitabine compound in the treatment of a neoplasm is provided.
06/12/14
20140163090
 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms patent thumbnailUse of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have essential thrombocythemia (et). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having et..
06/05/14
20140155678
 Focused radiation for augmenting immune-based therapies against neoplasms patent thumbnailFocused radiation for augmenting immune-based therapies against neoplasms
An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor.
06/05/14
20140155357
 Substituted tetracycline compounds patent thumbnailSubstituted tetracycline compounds
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression..
06/05/14
20140155280
 Method of diagnosing neoplasms patent thumbnailMethod of diagnosing neoplasms
The present invention relates generally to a method for screening a subject for the onset, predisposition to the onset and/or progression of a colorectal neoplasm by screening for modulation in the level of expression of one or more nucleic acid markers. More particularly, the present invention provides a method for screening a subject for the onset, predisposition to the onset and/or progression of a colorectal neoplasm by screening for modulation in the level of expression of one or more gene markers in membranous microvesicles.
06/05/14
20140154683
 Enrichment of nucleic acids by complimentary capture patent thumbnailEnrichment of nucleic acids by complimentary capture
Assays can be used to detect mutations found in neoplasms of the pancreas, as well as for other neoplasms and other uses. Nucleic acids can be captured from body fluids such as cyst fluids.
05/08/14
20140127691
Method for diagnosing type of pancreatic tumor
This invention is intended to provide a method capable of diagnosis of pancreatic tumor type at an early stage. More specifically, this invention relates to an examination method for determining pancreatic tumor type comprising detecting the degree of methylation in a 5′-untranslated region or a region comprising a 5′-untranslated region and a translated region of a gene encoding a mucin core protein in a pancreatic fluid sample from a subject, and identifying the pancreatic tumor as being of pancreatic tumor type selected from the group consisting of pancreatic ductal adenocarcinoma, an intraductal papillary mucinous neoplasm of the gastric type, an intraductal papillary mucinous neoplasm of the intestinal type, and an intraductal papillary mucinous neoplasm of the pancreatobiliary type using the degree of methylation as an index value..
04/24/14
20140113919
Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm
For simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferative diseases. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating proliferative diseases, in a mammal, particularly a human, with such a combination.
04/24/14
20140113913
Mcl-1 as a therapeutic target in scffbw7 deficient neoplasm
Some embodiments are based on the discovery that proliferative diseases (e.g., neoplastic diseases, for example, tumors or cancers) having an fbw7 mutation or other fbw7 deficiency are sensitive to mcl1 inhibiting agents, but resistant to pro-apoptotic drugs that do not inhibit mcl1. Some embodiments provide methods of treating a proliferative disease based on an assessment of fbw7 expression level or mutation status.
04/17/14
20140107147
Antineoplastic combinations containing hki-272 and vinorelbine
A combination of hki-272 compound and a vinorelbine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described..
04/17/14
20140106005
Compositions and methods of use of phorbol esters in the treatment of neoplasms
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease.
04/17/14
20140105821
Antibody that stops or slows tumour growth (variants)
A monoclonal antibody is described herein specifically binding to domains ii and iiic of fgfr1 or to a complex of fibroblast growth factor receptor type 1 and heparan sulphate. A method is proposed for suppressing tumour growth, based on blocking the human fibroblast growth factor/human fibroblast growth factor receptor type 1 (domains ii and iiic) pathway and involves administering the antibody.
04/10/14
20140099639
Panel for the detection and differentiation of renal cortical neoplasms
The present invention provides a novel, highly sensitive and specific probe panel which detects the type of renal cortical neoplasm present in a biopsy sample. As such, the invention permits diagnosis of the predominant subtypes of renal cortical neoplasms without the use of invasive methods.
03/06/14
20140066328
Predicting gastroenteropancreatic neuroendocrine neoplasms (gep-nens)
Described are embodiments related to gastroenteropancreatic neuroendocrine neoplasms (gep-nen) biomarkers and agents, systems, and kits for detecting the same, and associated gep-nen diagnostic, prognostic, and predictive methods and uses thereof, such as detection, prediction, staging, profiling, classification, and monitoring treatment efficacy and other outcomes.. .
03/06/14
20140065140
Cancer treatment using viruses and camptothecins
Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a sindbis virus, a picornavirus, and a myxoma virus.
02/27/14
20140057867
Compositions and methods of aloe polysaccharides
The present invention describes a method for preparing a polymannan extract from freeze-dried aloe powder. The polymannan extract of the present invention is further used to formulate a sterile injectable formulation for the treatment of one or more cancers, leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, immune diseases, particularly immune related neoplasms, acquired immune deficiency syndrome, and hepatitis c..
02/27/14
20140057262
Methods and materials for using the contents of phagocytes to detect neoplasms
This document provides methods and materials related to detecting premalignant or malignant neoplasms (e.g., colorectal and pancreatic cancer). For example, methods and materials for assessing the contents of phagocytes for the presence of one or more biological markers (e.g., alu repeats or methylated nucleic acid) of premalignant or malignant neoplasms are provided..
02/06/14
20140037695
Compositions and methods for targeting of treating neoplasms
Methods for treating neoplasm, tumors and cancers, using one or more tumor treating drug carriers, haptens and anticancer drugs, alone or in combination with other antineoplastic agents or treatments, are provided. Also provided are compositions, and kits containing the composition for affecting the therapy..
01/23/14
20140024036
Methods and materials for quantification of fusobacterium nucleatum dna in stool to diagnose colorectal neoplasm
Methods and materials for detecting colorectal cancer using dna markers from human stool. More specifically, methods and materials for quantification of fnn bacteria dna per unit stool weight as a molecular marker for crc diagnosis..
01/16/14
20140018329
Compositions and methods of use of phorbol esters in the treatment of neoplasms
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease.
01/16/14
20140017194
Compositions and methods of use of phorbol esters
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of cytopathic diseases. Cytopathic diseases may be caused by a variety means such as viral infections like hiv and aids, or the development of neoplasms in a mammalian subject.
01/09/14
20140011696
Bap1 mutational analysis in determining susceptibility to, prognosis of, and treatment of melanocytic neoplasia
Methods and compositions for diagnosing and prognosing neoplasms, particularly malignant melanomas, and for identifying patients at high risk for melanocytic nevi and/or melanomas or other cancers are provided. Methods for distinguishing between nevi at high and low risk for malignant transformation and for characterizing or classifying lesions or nevi are also disclosed.
01/02/14
20140005420
Salts and polymorphs of a tetracycline compound
Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general..
01/02/14
20140004209
Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
The subject matter disclosed herein relates to agents and methods of treating neoplasms with an agent that is a kinase inhibitor and is also an inducer of autophagy in combination with an agent that is an inhibitor of autophagy.. .
01/02/14
20140004192
Pharmaceutical formulations of indibulin and uses thereof
The present invention relates to pharmaceutical formulations that increase the solubility and bioavailability of indibulin, such as a spray-dried solid dispersion of indibulin with at least one matrix polymer. The invention further provides dosage formulations comprising the dispersion and processes for making the dispersion.
12/19/13
20130338020
Epigenetic markers of colorectal cancers and diagnostic methods using the same
The present invention relates generally to nucleic acid molecules in respect of which changes to dna methylation levels are indicative of the onset or predisposition to the onset of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to dna methylation levels are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or adenocarcinoma.
12/19/13
20130337070
Coated nanoparticle therapy for skin cancer
Disclosed herein are compositions useful as therapy and prevention of skin neoplasms, namely melanoma. Also disclosed herein are methods of using polymer-coated cerium nanoparticles as therapy against skin cancer.
12/19/13
20130337066
Membrane encapsulated nanoparticles and method of use
Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus.
11/28/13
20130316957
Smoothened polypeptides and methods of use
Disclosed is an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a smoothened (smo) protein, wherein the portion comprises an amino acid sequence of any of the intracellular loops of the smo protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment, wherein the functional fragment comprises at least 7 contiguous amino acids of the intracellular loops, and wherein the functional fragment or functional variant inhibits proliferation of a diseased cell, or a fatty acid derivative thereof. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided.
11/14/13
20130302441
Methods for the treatment of skin neoplasms
Methods of treating skin neoplasms using a monoamine oxidase inhibitor, e.g., a propynylaminoindan (such as rasagiline) are provided. Pharmaceutical compositions and kits comprising monoamine oxidase inhibitors are also provided..
10/24/13
20130280259
Use of antibodies against nk1, nk2 and/or nk3 receptors in cancer treatment
The object of this invention is the use of an antibody or a fragment thereof specific against nk1, nk2 and/or nk3 receptors of cells, for the manufacture of a medicament for the therapeutic management of human cancer, by direct administration to a mammal, including humans, by inducing cell death or apoptosis of tumour cells, modification of peritumoural microenvironment (consisting of stromal cells, stromal matrix, and intra and peritumoural vascularisation) and/or inflammatory and/or immune response around the tumour. In particular, in the case of melanoma, carcinoma (specially, breast carcinoma, lung, digestive system, prostate, cervix, endometrium, ovary and bladder), leukaemia, lymphomas, neoplasms, such as neuroblastoma and sarcoma, such as osteosarcoma..
09/12/13
20130237590
Assessing thyroid neoplasms
This document provides methods and materials involved in assessing thyroid neoplasms. For example, methods and materials for using microrna (mir) levels (e.g., mir122 levels) to determine whether a thyroid neoplasm (e.g., a follicular thyroid neoplasm) is benign or malignant as well as methods and materials for using mir levels (e.g., mir122 levels) to determine whether a malignant thyroid cancer patient is likely to have a favorable or unfavorable outcome are provided.
09/12/13
20130236497
Treating neoplasms with neurotoxin
The present invention provides a method of treating a cancer using a neurotoxin, preferably botulinum toxin (“btx”). The application of a neurotoxin around a cancer acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze cancer cells through efferent channels leaving the cancer vicinity to distant sites.
08/15/13
20130211384
Therapeutic agent, composition including said agent, implantable device and process for the treatment of cervical cancer and/or for the prevention of the formation of neoplasms in correspondence of the cervix in a human female genital system
A medical composition including a chemotherapeutic medication or a targeted therapy medication is used in a human female patient for the treatment of a disease selected in the group comprising cervical cancer, cervical intraepithelial neoplasia (cin), human papillomavirus (hpv) infection of the female genital system; the chemotherapeutic agent or targeted therapy medication is locally delivered directly to cervix of a female genital system by an implanted medical device including a stem to be implanted in the cervix. The stem has a drug carrying layer including the medical composition.
08/15/13
20130210124
Determination of cancer predisposition
Disclosed herein are systems and methods for using demethylation of genomic dna for diagnosing, predicting, and/or monitoring the status or outcome of a neoplasm or a cancer in a subject.. .
08/15/13
20130209578
Combinatory cancer treatment
The present invention relates to a pharmaceutical composition for treating a neoplasm, a preneoplasm, a proliferative disorder and/or a precancerous lesion, the use of such compositions for the treatment of the listed conditions, and methods of treating the listed conditions. The composition of the present invention comprises an inhibitor of eif4e, a methltransferase inhibitor, and a pharmaceutically acceptable carrier..
07/25/13
20130189248
Egfr inhibitor and antiviral agent for simultaneous, separate or sequential use in the treatment and/or prevention and/or palliation of cancer
The application relates to a combination of biologically active compounds comprising at least one antiviral agent and at least one egfr antagonist, for simultaneous, separate or sequential use in the treatment and/or prevention and/or palliation of malignant or pre-malignant neoplasms, preferably of solid malignant or pre-malignant neoplasms.. .
07/11/13
20130177548
Treating neoplasms with neurotoxin
The present invention provides a method of treating a neoplasm using a neurotoxin, preferably botulinum toxin. Neurotoxin administered around a neoplasm acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze neoplastic cells through efferent channels leaving the neoplasm to distant sites.
07/04/13
20130171271
Compositions and methods for enhancing the effectiveness of systemic, hipec, ip, and related cancer treatments
Methods for treating cancers, tumors, and neoplasms using a composition comprising one or more generally regarded as safe (gras) compounds selected from the group of components consisting of vitamins, selenium, fatty acids, fatty acid salts, and fatty acid esters, and mixtures of two or more said components, either as a stand-alone treatment or in combination with one or more anti-cancer drugs or devices or other anti-neoplastic agents, treatments, or devices are provided. In some instances, concomitant hyperthermia therapy is employed.
05/30/13
20130136799
Monitoring health and disease status using clonotype profiles
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using dna sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions.
05/02/13
20130109035
Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
The present invention relates to diagnostic, prognostic and clinical methods of distinguishing high-risk ipmn from more benign ipmn as well as high-grade panin and pdac from low-grade panin with moderate sensitivity and very high specificity using das-1 and related antibodies.. .
05/02/13
20130108713
Composition possessing antioxidant, immonomodulated, and antitumorous action and method of treating neoplasms
A composition produces antioxidant, immunomodulated, and antitumorous effects. The composition includes tannic acid, potassium iodide, and ascorbic acid.
04/25/13
20130102653
Gna11 and gnaq exon 4 mutations in melanoma
The present invention provides methods of detecting activating mutations in exon 4 of a gnaq or a gna11 gene in a melanocytic neoplasm for diagnostic and prognostic purposes. The invention further provides methods of treating such melanocytic neoplasm by modulating the activity of the mutated gnaq or gna11..
04/11/13
20130090550
Methods of identifying patients with ovarian epithelial neoplasms based on high-resolution mass spectrometry
Methods for identifying patients with ovarian neoplasms are provided herein comprising performing an assay step of detecting a metabolite in a serum sample of a patient where the metabolite is probably not produced by a tumor but could induce the development of a tumor, and the presence of the metabolite being indicative of an increased likelihood that the patient has ovarian cancer,. .
03/21/13
20130072485
Soluble mtor complexes and modulators thereof
The present invention relates to small molecule modulators of mtorc1 and mtorc2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases.
03/07/13
20130059301
Asxl1 as a new diagnostic marker of myeloid neoplasms
A method for diagnosing a myeloid cancer in a subject, includes the step of analyzing a biological sample from the subject by determining the presence or the absence of a mutation in the asxl1 (additional sex combs like 1) gene coding for the polypeptide having the sequence seq id n°2. A kit for diagnosing myeloid cancer in a subject including at least one nucleic acid probe or oligonucleotide or at least one antibody, which can be used in a such a method is also described..


Popular terms: [SEARCH]

Neoplasm topics: Autoimmune Disease, Autoimmune, Immune Disease, Neurotoxin, Graft Versus Host Disease, Botulinum Toxin, Modulation, Human Papillomavirus, Antibodies, Ascorbic Acid, Neoplastic, Proliferative, Epithelial, Neuroblastoma, Osteosarcoma

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This listing is a sample listing of patent applications related to Neoplasm for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Neoplasm with additional patents listed. Browse our RSS directory or Search for other possible listings.
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