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Natural Killer Cell

Natural Killer Cell-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Modified natural killer cells and natural killer cell lines having increased cytotoxicity
Onkimmune Limited
June 08, 2017 - N°20170157230

Nk cells and nk cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified nk cells and nk cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) trail ligand expression.
Smart car devices and de car polypeptides for treating disease and methods for enhancing immune ...
Chimera Bioengineering, Inc.
June 08, 2017 - N°20170157176

In an aspect, the present invention relates generally to the field of treating disease with car devices, smart car devices, de car devices, and/or smart-de car devices. The present invention also relates generally to the genetic modification of cytotoxic t-lymphocytes to reduce target cell killing by apoptosis and/or increase production of lytic proteins at desired times. In an ...
Ship inhibition to induce activation of natural killer cells
The Research Foundation For The State University Of New York
June 01, 2017 - N°20170151262

The present invention relates to the use or ship1 inhibitors and pan-ship1/2 inhibitors in various methods, including, without limitation, a method of inhibiting ship to induce broad activation of natural killer (nk) cells to treat various diseases.
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Development of natural killer cells and functional natural killer cell lines
University Of Utah Research Foundation
March 23, 2017 - N°20170081637

The invention relates to natural killer cells and methods for the development of immortalized natural killer cells and use of the natural killer cells. A growth and culture system is described that supports increased natural killer cell development, and provides for the establishment of continuous natural killer cell lines. Additionally, the disclosed method for generating natural killer cells may be ...
Regulatable chimeric antigen receptor
The Trustees Of The University Of Pennsylvania
March 23, 2017 - N°20170081411

Provided are compositions and methods relating to regulatable chimeric antigen receptors (rcars), natural killer cell receptor cars (nkr-cars), and regulatable nkr-cars (rnkr-cars), where the intracellular signaling or proliferation of the rcar or rnkr-car can be controlled to optimize the use of an rcar/nkr-car- or rnkr-car-expressing cell to provide an immune response. Cells can be engineered to express a rnkr-car ...
Modified natural killer cells and uses thereof
St. Jude Children's Research Hospital, Inc.
March 16, 2017 - N°20170073638

The present invention provides, in certain aspects, a natural killer (nk) cell that expresses all or a functional portion of interleukin-15 (il-15), and methods for producing such cells. The invention further provides methods of using a natural killer (nk) cell that expresses all or a functional portion of interleukin-15 (il-15) to treat cancer in a subject or to enhance expansion ...
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In vivo priming of natural killer cells
Immune Ventures Llc
March 16, 2017 - N°20170071982

The disclosure concerns a method for cancer treatment by in vivo priming and activation of natural killer cells for achieving tumor cell lysis. The method includes introducing into a patient a priming tumor cell preparation (ptcp) derived from a first tumor cell line, which is irradiated to inactivate the first tumor cells or a membrane preparation thereof, the first tumor ...
Methods of generating natural killer cells
Anthrogenesis Corporation
January 05, 2017 - N°20170002322

Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the nk cells produced by the method to an individual having the cancer or viral infection.
Modified natural killer cells, compositions and uses thereof
Fullhope Biomedical Co., Ltd.
November 10, 2016 - N°20160324895

Modified natural killer cells, pharmaceutical compositions comprising the modified natural killer cells and at least one pharmaceutically acceptable carrier or excipient, uses of the modified natural killer cells, and methods for identifying depleted natural killer cells and culturing the modified natural killer cells are provided.
Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
Anthrogenesis Corporation
October 06, 2016 - N°20160287635

Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat ...
Neuronal modulation
The Rappaport Institute
October 06, 2016 - N°20160287577

A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the ventral tegmental area (vta) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a cd8 t-cell, a cd4 t-cell, a b-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.
Analyzing immune signaling networks for identification of therapeutic targets in complex chronic medical disorders, identification ...
Nova Southeastern University
September 22, 2016 - N°20160275236

A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the cd3−/cd56+ natural killer (nk) cell population as a potential therapeutic target in the clinically-overlapping disorders gulf war illness (gwi) and myalg encephalomyelitis/chronic fatigue syndrome (me/cfs). The disclosure also provides a method ...
3d adcc nk facs assay
Hoffmann-la Roche Inc.
September 01, 2016 - N°20160252493

Herein is reported a cell analytical technology based on a three-dimensional spheroid/aggregate co-culture assay, wherein the spheroid or aggregate is formed of tumor and natural killer cells. This method is useful for the in vitro functional analysis of antibodies in single and high-throughput format.
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Development of natural killer cells and functional natural killer cell lines
Hoffmann-la Roche Inc.
April 21, 2016 - N°20160109431

The invention relates to natural killer cells and methods for the development of immortalized natural killer cells and use of the natural killer cells. A growth and culture system is described that supports increased natural killer cell development, and provides for the establishment of continuous natural killer cell lines. Additionally, the disclosed method for generating natural killer cells may be ...
Cytokine derived treatment with reduced vascular leak syndrome
Institut Gustave Roussy (igr)
March 10, 2016 - N°20160068584

The present invention relates to a pharmaceutical composition for treating a cancer or an infection in a subject by administrating an amount of an il-15 derivative conjugate so as to induce a proliferation of natural killer cells (nk cells) which is the same or higher than the one obtained with high dose of interleukin-2 (hdil-2); eventually associated with a pharmaceutically ...
Genetically modified human natural killer cell lines
Fox Chase Cancer Center
March 10, 2016 - N°20160067356

The invention provides a natural killer cell, nk-92, modified to express an fc receptor on the surface of the cell, such as cd 16 (fcγriii-a), or other fcγ or fc receptors. The modified nk-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as fcεri-γ,tcr-&#...
Natural killer cells from placenta
Anthrogenesis Corporation
December 24, 2015 - N°20150366910

Provided herein are placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, combined natural killer cells from placenta and umbilical cord blood, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, and combined natural killer cells and combinations thereof, to suppress the growth ...
Method of providing cellular therapy using modified natural killer cells or t lymphocytes
Bloodcenter Research Foundation
September 17, 2015 - N°20150258143

A method of decreasing cytokine production and release is disclosed. In one embodiment, the method comprises the step of providing cytotoxic cells to a subject wherein the cells are preferably natural killer cells or t lymphocytes and are genetically modified to express a chimeric antigen receptor comprising a first element that is an extracellular antigen receptor and a second intracellular ...
Natural killer cells and uses thereof
Anthrogenesis Corporation
August 13, 2015 - N°20150225697

Provided herein are methods of producing natural killer (nk) cells and nk progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of nk cells and nk progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the nk cells, the ...
Chimeric nk receptor and methods for treating cancer
National Institutes Of Health (nih), U.s. Dept. Of Health And Human Services (dhhs)
August 13, 2015 - N°20150225470

The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a c-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
Industrial preparation of natural killer cells (nks) and injection using human allo-geneic karyocytes
National Institutes Of Health (nih), U.s. Dept. Of Health And Human Services (dhhs)
August 06, 2015 - N°20150218518

Disclosed is an industrial preparation of natural killer cells (nks) and an injection using human allogeneic karyocytes comprising: using umbilical cord blood and peripheral blood from legitimate sources as raw materials, obtaining stem cells by a method for extracting and separating karyocytes, or using ficoll or percoll density gradient centrifugation to isolate and screen out karyocytes; diluting the above-mentioned karyocytes ...
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