 Patent Application Title |
Patent App Num. |
Date |
 Rich air sprayer of sanitary ware | 20130118538 | 20130516 |
 A rich air sprayer of sanitary ware has a base, the base is disposed with at least two waterways; each waterway includes an inlet hole, a mutation cavity connected to the inlet hole and an air inlet hole connected to the mutation cavity, the flow area of the inlet hole is smaller than that of the mutation cavity, negative pressure is generated inside the mutation cavity when the water flows from the inlet hole into the mutation cavity, the negative pressure makes the mutation cavity suck air from the outside of the sprayer through the air inlet hole, the air and the water are mixed to form bubbles; the outlets of the mutation cavities intersect or the tangents of the outlets of the mutation cavities intersect,... |
| Methods and compositions using fgf23 variant polypeptides | 20130122004 | 20130516 |
 The present disclosure is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The fusion polypeptides of the disclosure include FGF23 or an active fragment thereof. In one embodiment, the fusion polypeptide comprises (a) a polypeptide comprising fibroblast growth factor 23 (FGF23), or a functionally active variant or derivative thereof, wherein FGF23 has a mutation at one or more of the positions Q156, C206 and C244; and (b) either a modified Fc fragment having decreased affinity for Fc-gamma-receptor and/or increased serum half-life, or a polypeptide comprising at least one extracellular subdomain of a Klotho protein, or a functionally active variant or derivative thereof; and, optionally (c) a linker. The Klotho fusion proteins are useful in the treatment and prevention of... |
| Microalgal food compositions | 20130122180 | 20130516 |
 Compositions of microalgae-derived food compositions, including flours and beverages, are disclosed from multiple genera, species, and strains of edible microalgae. Microalgae used in the invention are free of algal toxins and contain varying levels of primarily monounsaturated triglyceride oil. Also provided herein are microalgae-containing baked goods with novel properties compared to preexisting products of the same type, and foods containing microalgae biomass with high levels of lipid. Compositions and methods of the invention also relate to the creation of food products based on eggs, wherein the productions contain various raw materials made from microalgae in different forms. The invention also provides unique and novel strains of microalgae that have been subjected to non-transgenic methods of mutation sufficient to reduce the coloration of biomass produced by the... |
| Eubacterial rna-polymerase mutants with altered product production | 20130122548 | 20130516 |
 The present invention relates to an isolated mutant eubacterium comprising at least one mutation resulting in a substitution of at least one amino acid in the beta-subunit of the RNA-polymerase encoded for by the rpoB-gene providing an altered production of a product of interest when said production of a product of interest is compared to the production of the same product in an isogenic wild type strain grown at identical conditions, wherein the substitution of at least one amino acid occurs at any of positions 469, 478, 482, 485, or 487 of SEQ ID NO:2, or at the equivalent positions in any eubacterial RNA-polymererase beta-subunit family member. Another aspect of the invention relates to a process for producing at least one product of interest in a... |
| Multi-site mutagenesis | 20130122550 | 20130516 |
 The present invention provides compositions and improved methods for multi-site directed mutagenesis and DNA shuffling. The present compositions and methods provide increased mutation frequency and increased number of transformants which allow one to sequence only a few clones in order to identify the correct mutants and to obtain the desired mutant by screening large number of transformants in a short time. Moreover, the inclusion of FEN-1, PEF and optimized buffer and cycling conditions provided in the present invention should also facilitate random mutagenized library construction and the mutagenesis of large or difficult templates.
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| Mutant delta-5 desaturases and their use in making polyunsaturated fatty acids | 20130122558 | 20130516 |
| The present invention relates to mutant Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid [DGLA; 20:3 ω-6] to arachidonic acid [ARA; 20:4 ω-6] and/or eicosatetraenoic acid [ETA; 20:4 ω-3] to eicosapentaenoic acid [EPA; 20:5 ω-3] and which possess at least one mutation within the HPGG motif of the cytochrome b5-like domain. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant Δ5 desaturases in oleaginous yeast, are disclosed.
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| Live vaccine strain | 20130122573 | 20130516 |
| A strain of Francisella species wherein a gene which encodes for part of the glutamate metabolic pathway has been inactivated, and which is able to produce a protective immune response in an animal, for use as live prophylactic or therapeutic vaccine against infection by said Francisella species. Particularly effective strains include those where the capB gene is deleted. Other embodiments of the invention describe strains which compromise a further genetic mutation wherein a gene which encodes for another component of the cell is also inactivated. Pharmaceutical compositions comprising said strains, together with methods which utilize such strains are also described and claimed.
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| Methods of targeting pten mutant diseases and compositions therefor | 20130123273 | 20130516 |
| Provided herein are methods, uses and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation. In particular embodiments, the methods comprise administering to the patient a composition comprising a therapeutically effective amount of a PLK4 antagonist, and identifying a patient that is likely to be responsive to PLK4 antagonist therapy, if PTEN gene mutation is present.
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| Method to detect repeat sequence motifs in nucleic acid | 20130115595 | 20130509 |
| Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1 gene and FMR2 gene due to the expansion of CGG repeats and CCG repeats in the 5′-untranslated region respectively. The methods are also useful for screening newborns for fragile X syndrome or for screening women to determine heterozygosity status with full premutation of the CCG repeat tract. The methods are also useful in estimating the premutation and full mutation carrier frequency and estimating the prevalence of FXTAS AND FXPOI in a population. The methods are simple,... |
| Oligonucleotide probe retrieval assay for dna transactions in mammalian cells | 20130115598 | 20130509 |
| Methods to measure a variety of DNA synthetic processes in live human cells by introducing and retrieving exogenous DNA probes are provided herein. Using fragments of bacterial plasmid or phage DNA, a wide array of DNA constructs may be assembled to mimic the intermediates of DNA transactions, including replication, translation synthesis, and end-joining. These DNA probes may be transfected into human cells and retrieved for mutational analysis using a modified Random Mutation Capture assay or NextGen DNA sequencing. These assays require only a small number of cells, such as might be available from biopsy material. Thus, the methods described herein may be applied to the early detection of cancer, predicting the responsiveness of individual cancers to chemotherapy, and measuring the DNA repair capacity of individuals to... |
| Engineered yeast cells and uses thereof | 20130115656 | 20130509 |
| The present application provides engineered yeast cells and uses thereof. In specific embodiments, the yeast cells have a mutation in the GAL2 gene. In specific embodiments, the yeast cells can be used for producing a protein or compound of interest.
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| Bioprocessing ligno-cellulose into ethanol with recombinant clostridium | 20130115669 | 20130509 |
| The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the... |
| Thuja plant named 'concesarini' | 20130117897 | 20130509 |
| A new Thurja occidentalis (i.e., American Arborvitae) plant is provided which originated as a whole plant mutation of the ‘Linesville’ variety (non-patented in the United States). Unlike the parental variety, the new plant displays a distinctive much lower growing dense globular rounded growth habit. Good winter hardiness is displayed and the plant resists sun and winter burning. The plant is well suited for providing attractive and uniform ornamentation close to ground level.
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| Analysis of y-chromosome str markers | 20130109579 | 20130502 |
| The methods and compositions provided herein relate to the discovery of 13 STR markers, found on the human Y chromosome, having surprisingly high mutation rates when compared with 173 other Y-STR markers known today. The set of RM-Y-STRs may overcome the current dilemma of Y-chromosome analysis in forensic applications due to their extraordinary mutation properties. Embodiments of the invention include methods for allelic determination of rapidly-mutating Y-STR markers, amplification primers for the analysis of rapidly-mutating Y-STR markers, allelic ladders for analysis of rapidly-mutating Y-STR markers, and kits for the analysis of rapidly-mutating Y-STR markers.
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| Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders | 20130109645 | 20130502 |
| Disclosed are a method of treating or preventing a disorder in a mammal comprising administering to the mammal an adenosine receptor agonist or an adenosine receptor antagonist, either alone or in combination, in an amount effective to treat or prevent medial vascular or joint capsule calcification. Disclosed are methods of detecting or diagnosing a vascular or joint capsule calcification disorder, as well as a nucleic acid comprising a mutation in one or more exons of human NT5E selected from the group consisting of Exon 3, Exon 5, and Exon 9.
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| Biomarkers for non-hodgkin lymphomas and uses thereof | 20130102477 | 20130425 |
| The disclosure provides a method of identifying a subject as having B-cell non-Hodgkin lymphoma (NHL) such as testing a sample from a subject for a mutation in one or more biomarkers. Also described are methods for classifying or monitoring a subject having, or suspected of having, B-cell non-Hodgkin lymphoma comprising testing the sample for a mutation in one or more biomarkers.
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| Treatment of cancers having k-ras mutations | 20130102595 | 20130425 |
| The present invention provides a method of treating a cancer associated with a K-ras mutation in a subject in need thereof. The method comprises the steps of: (1) identifying a subject with a cancer associated with a K-ras mutation; and (2) administering to the subject (i) an inhibitor of PI3 kinase and (ii) an HDAC inhibitor, wherein the PI3 kinase inhibitor and the HDAC inhibitor are administered in amounts which together are therapeutically effective.
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| Prophylactic or ameliorating agent for genetic diseases | 20130102644 | 20130425 |
| An object of the present invention is to provide a prophylactic or ameliorating agent for a genetic disease that is caused by a mutation in an exon of a gene and is capable of forming a functional truncated protein by skipping of the exon comprising the mutation. The prophylactic or ameliorating agent used in the present invention is a prophylactic or ameliorating agent for a genetic disease that is caused by a mutation in an exon of a gene and is capable of forming a functional truncated protein by skipping of the exon comprising the mutation, wherein the prophylactic or ameliorating agent contains a compound having a molecular weight of 1500 or lower.
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| Gene splicing defects | 20130096838 | 20130418 |
| Predicting the effect of a mutation in a nucleic acid sequence on splicing is accomplished by determining the distance between at least two nucleic acid sequence positional distributions and providing a prediction of impact on splicing function based on at least the distance. A low distance indicates there is little or no difference in splicing function compared to a normal control. A high distance indicates a difference in splicing function. Related apparatus, systems, techniques and articles are also described.
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| Development of dengue virus vaccine components | 20130089567 | 20130411 |
| The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR;... |
| Agent for suppressing expression of dominant allele | 20130090373 | 20130411 |
| An agent for selectively suppressing the expression of a dominant allele while allowing expression of wild-type or desired alleles and methods for using the agent are described. The RNAi agent has a structure obtained by assigning a dominant point mutation in the targeted allele as a standard point, setting a base length from the standard point to the 5′ end to a predetermined length, and introducing one mismatch base differing from the target sequence to a predetermined position downstream from the standard point.
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| Methods of identifying lead compounds that modulate toxicity of neurotoxic polypeptides | 20130084596 | 20130404 |
| Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
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| Apple tree named das-10 | 20130086713 | 20130404 |
| A new and distinct strain of apple, designated ‘DAS-10’, originated as a whole tree mutation in a ‘Honeycrisp’ planting. The fruit ripen 21 days earlier than parent tree fruit, which will provide fruit producers with an opportunity to sell high quality apple fruit earlier than either ‘Honeycrisp’ or ‘Gala.’ Fruit color and eating quality are similar to ‘Honeycrisp.’
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| Methods for the diagnosis and therapy of retinitis pigmentosa | 20130071373 | 20130321 |
| The present invention relates to a method of identifying a subject having or at risk of having or developing a retinitis pigmentosa, comprising detecting in a sample obtained from said subject, the presence of at least one mutation in the rhodopsin (RHO) gene selected from the group consisting of c.263T>C, c.620T>A and c. 1031A>C wherein the presence of said mutation indicates an increased risk of having or being at risk of having or developing the retinitis pigmentosa.
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| Interferon-ß production modulating listeria strains and methods for using same | 20130071433 | 20130321 |
| Mutant Listeria bacteria that modulate interferon-B production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR gene, a MarR gene a MdrL gene, a MdrT gene and a MdrM gene. The subject bacteria find use in a variety of applications, where representative applications of interest include, but are not limited to: (a) use of the subject bacteria as adjuvants; (b) use of the subject bacteria as delivery vectors for introducing macromolecules into a cell; (c) use of the subject bacteria as vaccines for eliciting or boosting a cellular immune response; etc.
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| Novel mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor | 20130065237 | 20130314 |
| [Means for Solving Problems] 1) A mixture which comprises one internal standard nucleic acid and two nucleic acid probes labeled with a fluorescent dye; 2) a mixture for measuring Km value which comprises one internal standard nucleic acid having a partial mutation and one nucleic acid probe labeled with a fluorescent dye; 3) a mixture which comprises one internal standard nucleic acid and one double nucleic acid probe labeled with two fluorescent dyes; and a method for assaying a nucleic acid by making use thereof.
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| Mutator activity induced by microrna-155 (mir-155) links inflammation and cancer | 20130065938 | 20130314 |
| Methods of reducing spontaneous mutation rate of a cell in a subject in need thereof by reducing endogenous levels of miR-155 are described.
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| Gene for identifying individuals with familial dysautonomia | 20130066060 | 20130314 |
| This invention relates to methods and compositions for detecting mutations causing Familial Dysautonomia (FD), an Ashkenazi Jewish disorder characterized by widespread sensory and variable autonomic dysfunction. Previously, we mapped the FD gene, DYS, to a 0.5 cM region of chromosome 9q31. We sequenced the minimal candidate region and cloned and characterized its 5 genes. IKBKAP harbors two mutations that can cause FD. The major haplotype mutation is located in the donor splice site of intron 20. This mutation can result in skipping of exon 20 in the mRNA from FD patients, although they continue to express varying levels of wild-type message in a tissue-specific manner. RNA isolated from patient lymphoblasts is primarily wild-type, whereas only deleted message is seen in RNA from isolated brain. The mutation... |
| Meganuclease variants cleaving a dna target sequence from a rag gene and uses thereof | 20130067607 | 20130314 |
| An I-CreI variant, wherein one of the I-CreI monomers has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG core domain situated respectively from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from a RAG gene. Use of said variant and derived products for the prevention and the treatment of a SCID syndrome associated with a mutation in a RAG gene.
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| Compositions and methods related to anti-fgf agents | 20130058896 | 20130307 |
| The invention relates to an isolated amino acid that can act as an antagonist to FGF signaling, comprising at least a portion of the FGF protein amino acid sequence, and including a mutation in either a) the integrin αvβ3 binding region of FGF-1; or b) the FGFR binding region of FGF-1.
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| Control system and user interface for network of input devices | 20110016234 | 20110120 |
| Apparatus, methods, and systems for centrally and uniformly controlling the operation of a variety of devices, such as communication, consumer electronic, audio-video, analog, digital, 1394, and the like, over a variety of protocols within a network system and, more particularly, a control system and uniform user interface for centrally controlling these devices in a manner that appears seamless and transparent to the user. In a preferred embodiment, a command center or hub of a network system includes a context and connection permutation sensitive control system that enables centralized and seamless integrated control of all types of input devices. The control system preferably includes a versatile icon based graphical user interface that provides a uniform, on-screen centralized control system for the network system. The user interface, which... |
| Detection of truncation mutations by mass spectrometry | 20110015369 | 20110120 |
| This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as mass difference.
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| Selection of host cells expressing protein at high levels | 20110014655 | 20110120 |
| The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a selectable marker polypeptide functional in a eukaryotic host cell, and for ii) a polypeptide of interest, the polypeptide of interest having a translation initiation sequence separate from that of the selectable marker polypeptide, characterized in that the coding sequence for the polypeptide of interest is downstream from the coding sequence for the selectable marker in the multicistronic transcription unit, and the nucleic acid sequence coding for the selectable marker polypeptide comprises a mutation that decreases the translation efficiency of the selectable marker in a eukaryotic host cell. The invention also provides methods for obtaining host cells expressing a polypeptide of interest, the host cells comprising the DNA molecules of the invention.... |
| Screening method for predicting susceptibility to breast cancer | 20110014206 | 20110120 |
| A method to aid in identifying a familial or sporadic pattern of risk in at least one individual for developing cancer of a mucosal epithelial tissue, the method comprising screening said at least one individual for heterozygosity or homozygosity for a mutation in a gene coding for a Poly-Ig (Fc) receptor or a Poly-Ig-like (Fc) receptor capable of mediating inhibition of cancer cell growth by an immunoglobulin inhibitor. A method of treating an individual so identified includes enhancing the amount of immunoglobulin inhibitor contacting a mucosal epithelial tissue of said individual, and, especially in individuals homozygous for the defective receptor, may also include prophylactic surgery. Other methods include implementation of a risk reduction or prevention program in individuals identified as being at risk.
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| Time-frequency space constructions of families of signals | 20110013716 | 20110120 |
| A computer-implemented method and system for generating large families of sequences with desirable properties for many applications, including communications and radar applications, applies constraints to a sequence in the Zak space, modulates the constrained sequence in the Zak space, and determines permutations of the modulated sequence in the Zak space. The constraints are associated with predetermined properties, including predetermined autocorrelation and cross-correlation properties. Other embodiments of the computer-implemented method and system transform an input sequence into a transformed sequence using the finite Zak transform and determine at least one other different sequence based on the transformed sequence. The at least one other different sequence can be determined by collecting a plurality of sequences that are finitely supported on an algebraic line in the Zak space and... |
| System and method for a high efficiency remote three phase fan commutation integration control in an information handling system | 20110012547 | 20110120 |
| An information handling system includes a three phase brushless direct current motor and a motherboard which in turn includes a drive circuit. The three phase brushless direct current motor is configured to rotate a cooling fan in the information handling system based on a control signal. The drive circuit is connected to the three phase brushless direct current motor, and the drive circuit is configured to adjust the control signal sent to the three phase brushless direct current motor based on a back electromagnetic flux signal.
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| Method of directing the evolution of an organism | 20110010806 | 20110113 |
| The present disclosure relates to a method of directing the evolution of an organism by modifying the mutation rate of an organism. The increase in genetic diversity may be used to facilitate the selection of a desired hereditary trait in an organism.
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| Method to develop high oleic acid soybeans using conventional soybean breeding techniques | 20110010791 | 20110113 |
| The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid.
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| Products and their use for the diagnosis, prevention and/or care of human and/or animal pathologies characterised by the anomalous deposition of b-amyloid and/or amyloid-like substance in human and/or animal organs and tissues, and screening method for de | 20110010785 | 20110113 |
| The patent refers to a screening method carried out on biological material isolated from human and/or animal organisms for determining the risk of human and/or animal pathologies expressing an anomalous deposition of β-amyloid and/or amyloid-like substance in human and/or animal organs and tissues, based on the investigation of the punctiform mutation Ala>Val in position 2 of the β-protein (corresponding to the Ala673Val mutation precursor of the β-protein containing 770 amino acids) in homozygosis or in heterozygosis. The patent provides for the possibility of: (1) creating unicellular or multicellular transgenic organisms expressing the Ala673Val mutation; (2) synthesising or producing peptides with such mutation and/or their derivatives and/or nucleic acids containing the same mutation; (3) using such products for studying the pathogenesis of the pathologies characterised by anomalous... |
| Control system and user interface for home theater network | 20110010744 | 20110113 |
| Apparatus, methods, and systems for centrally and uniformly controlling the operation of a variety of devices, such as communication, consumer electronic, audio-video, analog, digital, 1394, and the like, over a variety of protocols within a network system and, more particularly, a control system and uniform user interface for centrally controlling these devices in a manner that appears seamless and transparent to the user. In a preferred embodiment, a command center or hub of a network system includes a context and connection permutation sensitive control system that enables centralized and seamless integrated control of all types of input devices. The control system preferably includes a versatile icon based graphical user interface that provides a uniform, on-screen centralized control system for the network system. The user interface, which... |
| Clarification of sphingans and compositions thereof | 20110009611 | 20110113 |
| The invention relates to mutant strains of the genus Sphingomonas which have a mutation in at least one gene encoding a protein involved in polyhydroxybutyrate (“PHB”) synthesis that allows the mutant strains to produce PHB-deficient sphingans. The invention is also directed to a process for preparing a clarified sphingan solution comprising heating aqueous sphingan solution, in particular PHB-deficient sphingan solution, to a clarification temperature of about 30° C. to about 70° C., and treating the solution with a clarification agent and enzymes. In addition, the invention is directed to a food or industrial product comprising a PHB-deficient and/or clarified sphingan. One particular embodiment of the invention is directed to a clarified, PHB-deficient high-acyl gellan and the processes of making thereof.
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| Q3 sparc deletion mutant and uses thereof | 20110009337 | 20110113 |
| The invention provides for SPARC polypeptides with a mutation corresponding to a deletion of the third glutamine in the mature fault of the human SPARC protein, nucleic acids encoding such polypeptides, antibodies against such polypeptides, and methods of the use of such polypeptides, nucleic acids, and antibodies.
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| Novel lactose phosphorylase enzymes | 20110008849 | 20110113 |
| The present invention relates to novel lactose phosphorylase enzymes and the uses thereof. More specifically, the invention relates to lactose phosphorylase enzymes created by mutation of a cellobiose phosphorylase from Cellulomonas uda. By introducing mutations in this enzyme, the activity can be switched from cellobiose phosphorylase into lactose phosphorylase.
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| Cystic fibrosis transmembrane conductance regulator gene mutations | 20110008790 | 20110113 |
| The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further provided.
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| Enhancement of light activated drug therapy through combination with other therapeutic agents | 20110008372 | 20110113 |
| The efficacy of light activated therapy treatment is enhanced by use of additional therapeutic agents. Abnormal tissue is destroyed by light activated therapy, and the associated administration of one or more additional therapeutic agents can synergistically enhance the therapy. For example, the concepts disclosed herein encompass the use of the following agents in combination with light activated drug therapy: (1) agents that selectively inhibit heat shock protein 90 (Hsp90); (2) agents that inhibit the Hedgehog pathway (which is believed to play a central role in allowing the proliferation and survival of certain cancer-causing cells, and which is implicated in many of the most deadly cancers); and, (3) agents for reducing the anti-apoptotic effects of Bcl-2 or Bcl-xL. These agents can be used with light activated drug... |
| Unified system and method for animal behavior characterization with training capabilities | 20110007946 | 20110113 |
| In general, the present invention is directed to systems and methods for finding the position and shape of an object using video. The invention includes a system with a video camera coupled to a computer in which the computer is configured to automatically provide object segmentation and identification, object motion tracking (for moving objects), object position classification, and behavior identification. In a preferred embodiment, the present invention may use background subtraction for object identification and tracking, probabilistic approach with expectation-maximization for tracking the motion detection and object classification, and decision tree classification for behavior identification. Thus, the present invention is capable of automatically monitoring a video image to identify, track and classify the actions of various objects and the object's movements within the image. The image... |
| Biopolar power control | 20110007525 | 20110113 |
| This invention relates to a circuit for controlling a power converter featuring BJTs, through use of a control winding on the transformer that provides the base drive for the BJTs. This controller can control the control winding current, thus modifying the commutating of the current or stopping the oscillations. It can provide unidirectional shorts to prevent commutation and can also provide an initial power pulse to control the start or operation of the power converter.
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| Device and method for taking a safety precaution an in electrical tool | 20110007436 | 20110113 |
| The invention relates to a device (10) for taking a safety precaution in an electrical tool, said electrical tool comprising an electric motor (EM) with at least one field winding and an armature winding. The device (10) comprises the following features: a sensor unit (12) which is designed to generate a sensor signal (21) in accordance with a motor current (14) passing through the electric motor (EM), an armature voltage (16) via the armature winding, a voltage (18) via the field winding and/or a commutation frequency (20) in the armature winding; a unit (22) detecting a change of the sensor signal, which is designed to detect a temporal change of the sensor signal (21) and emit a corresponding modification signal (24) on the basis of the... |
| Compact fpga-based digital motor controller | 20110006713 | 20110113 |
| A compact field programmable gate array (FPGA)-based digital motor controller (102), a method, and a design structure are provided. The compact FPGA-based digital motor controller (102) includes a sensor interface (206) configured to receive sensor data from one or more sensors (104) and generate conditioned sensor data. The one or more sensors (104) provide position information for a DC brushless motor (108). The compact FPGA-based digital motor controller (102) also includes a commutation control (210) configured to create switching commands to control commutation for the DC brushless motor (108). The commutation control (210) generates commutation pulses from the conditioned sensor data of the sensor interface (206). The compact FPGA-based digital motor controller (102) also includes a time inverter (208) configured to receive the commutation pulses. The... |
| Method and apparatus of deriving security key(s) | 20110004760 | 20110106 |
| A method, apparatus and a wireless communication system to derive security key(s) over an air link in a secure manner by sending by a mobile station over the air a single direction permutation of a mobile station ID, establishing keys with the base station and sending the mobile station real ID in a secure manner.
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| Base sequence determination program, base sequence determination device, and base sequence determination method | 20110004616 | 20110106 |
| It is intended to provide a base sequence determination program, a base sequence determination device, and a base sequence determination method capable of constructing the whole genome sequence from an enormous amount of short base sequences of approximately several tens-base-long without referring to existing base sequences. In the invention, base sequences of two kinds of parent lineages carrying a genetic mutation and base sequences of a plurality of descending progenies of the generation after segregation are each analyzed, and segregation at a polymorphic site is referred to as an index of connection of the base sequences, and fragments of the base sequences are connected while verifying the validity of the segregation.
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| Novel compounds derived from indole and pharmaceutical compositions containing them | 20110003843 | 20110106 |
| wherein X represents N, CR8 or N+R8, wherein R8 represents a hydrogen atom, a hydroxyl or alkyl or methoxy group optionally substituted with a phenyl group; R2, R3 and R4 independently represent a hydrogen atom or a halogen atom or an optionally substituted alkyl, amine, alkene, ester, sulfonamide, ether or benzyl group; R5 represents a hydrogen atom or an optionally substituted, saturated or unsaturated alkyl group, amine, benzyl group; R6 represents an optionally substituted C1-C3 alkyl group; R7 represents a hydrogen atom or an optionally substituted C1-C3 alkyl group and R7 is absent when the ring A is in the b position, and A represents a ring; R9 and R10 represent together a carbon bond or independently represent an R11 OR11, SR11 group; wherein R11 represents... |
| Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices | 20110003712 | 20110106 |
| This invention pertains to methods, kits and compositions suitable for the detection, identification and/or quantitation of nucleic acids which are electrostatically immobilized to matrices using non-nucleotide probes which sequence specifically hybridize to one or more target sequences of the nucleic acid but do not otherwise substantially interact with the matrix. Once the nucleic acid is immobilized, the detectable non-nucleotide probe/target sequence complex, formed before or after the immobilization of the nucleic acid, can be detected, identified or quantitated under a wide range of assay conditions as a means to detect, identify or quantitate the target sequence in the sample. Because it is reversibly bound, the non-nucleotide probe/target sequence can optionally be removed from the matrix for detecting, identifying or quantitating the target sequence in the sample.... |
| Tumor necrosis factor-gamma | 20110003399 | 20110106 |
| Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
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| L-threonine overproducing microorganism and method for preparing l-threonine using the same | 20110003349 | 20110106 |
| The present invention relates to a mutant microorganism producing a high concentration of L-threonine in high yield, prepared using site-specific mutation, not random mutation, such as treatment with a mutation inducer, a method for preparing the same, and a method for preparing L-threonine using the mutant microorganism producing L-threonine. By using the mutant microorganism according to the present invention, L-threonine can be prepared at high yield, additional strain development becomes possible and their physiological phenomena can be easily understood since genetic information of L-threonine producing microorganism can be identified.
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| Methods for increasing the therapeutic efficacy of immunoglobulin g class 3 (igg3) antibodies | 20110003336 | 20110106 |
| The present invention relates to methods for increasing the therapeutic efficacy of immunoglobulin G class 3 (IgG3) antibodies, immunoglobulin G class 3 (IgG3) antibodies with an improved therapeutic efficacy and the use thereof as a medicament, in particularly a medicament for immunotherapy. Specifically, the present invention relates to methods for increasing the therapeutic efficacy of an immunoglobulin G class 3 (IgG3) antibody comprising providing a mutated immunoglobulin G class 3 (IgG3) antibody, wherein the mutation, as compared to the parent immunoglobulin G class 3 (IgG3) antibody, comprises a replacement of the amino acid arginine (R) at position 435 in the CH3 domain with the amino acid histidine (H), and antibodies obtained by the present methods and their use as a medicament.
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| Diagnosis and treatment of congenital heart defects using nell1 | 20110002893 | 20110106 |
| The present invention provides diagnostic methods for detecting congenital heart defects, or increased risk thereof, based on the Nell1 gene, RNA and protein. The methods include obtaining a biological sample and assessing the presence of a mutation in the Nell1 gene, RNA or protein. The presence of a mutation in the Nell1 gene, RNA or protein can be assessed by determining the levels of Nell1 gene, RNA or protein in the biological sample. The present invention further provides therapeutic methods for treating congenital heart defects based on the Nell1 gene. RNA and protein.
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| Method of transmitting ack/nack signal in wireless communication system | 20110002309 | 20110106 |
| A method of transmitting an acknowledgement (ACK)/non-acknowledgement (NACK) signal in a wireless communication system is provided. The method includes: allocating a radio resource; and transmitting the ACK/NACK signal through an ACK channel in a location determined by an index for the radio resource, wherein the radio resource includes at least one resource unit which is a basic unit for resource allocation, the resource unit is at least one of a localized resource unit including subcarriers contiguous in a frequency domain and a distributed resource unit including subcarriers distributed in the frequency domain, an index of the localized resource unit is directly mapped to an index of the ACK channel, and an index of the distributed resource unit is mapped to an index of the ACK channel... |
| Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | 20100331418 | 20101230 |
| Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor.
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| Cis-aconitate decarboxylase mutants having improved enzymatic activity | 20100330632 | 20101230 |
| Cis-aconitate decarboxylase mutants having one or more mutations in a C-terminal region as compared with a wild-type cis-aconitate decarboxylase of Aspergillus terreus.
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| Use of the ocp3 mutation to regulate drought resistance in plants | 20090328246 | 20091231 |
| The invention relates to the technical field of plant biotechnology and, more specifically, to the use of the OCP3 gene as a regulator of drought resistance in plants and to the resulting plants having said drought resistance or increased drought tolerance.
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| Transient protection key derivation in a computing device | 20090327722 | 20091231 |
| A computing device is arranged to use any possible permutation of methods available to it to authenticate a user, without needing to persistently store any unencrypted data that can be used in authentication, such data only ever being held in transient memory. A user of the device is provided with their own unique common protection key (CPK) which can be used to guard or encrypt sensitive data and functionality. Each authentication method is guaranteed to return a unique consistent identification sequence (CIS) each time it is employed by any specific user. When a user registers on the device, the CIS from each authentication method is used to generate a key which in turn is used to encrypt the CPK; this E(CPK) is then stored in a... |
| Client side reconciliation of typographical errors in messages from input-limited devices | 20090326922 | 20091231 |
| A method for reconciling typographical errors, includes: receiving an electronic text message from a pervasive device with limited input keypads on a receiving device configured with a messaging application; determining an input protocol of the pervasive device; examining the electronic text message for words that are not in the messaging application's dictionary; identifying words that are not in the messaging application's dictionary; mapping each of the identified words to a set of keystrokes used to produce each of the identified words based on a series of input protocols that the receiving device has stored in a memory; utilizing each set of keystrokes from each of the input protocols in an algorithm to compute each permutation of the keystrokes; checking the computed permutations against the messaging application's... |
| Method of analyzing a brca2 gene in a human subject | 20090325238 | 20091231 |
| Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2(omi 1-5) and the ten polymorphic sites will provide greater accuracy and reliability for genetic testing. One skilled in the art will be better able to avoid misinterpretations of changes in the gene and/or protein sequence, determine the presence of a normal sequence, and of mutations of BRCA2. This invention is also related to a method of performing gene therapy with BRCA2(omi 1-5) coding sequences or fragments thereof. This invention is further related to protein therapy with BRCA2(omi 1-5) proteins or their functional equivalents.
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| Method of analyzing a brca2 gene in a human subject | 20090325237 | 20091231 |
| Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2(omi 1-5) and the ten polymorphic sites will provide greater accuracy and reliability for genetic testing. One skilled in the art will be better able to avoid misinterpretations of changes in the gene and/or protein sequence, determine the presence of a normal sequence, and of mutations of BRCA2. This invention is also related to a method of performing gene therapy with BRCA2(omi 1-5) coding sequences or fragments thereof. This invention is further related to protein therapy with BRCA2(omi 1-5) proteins or their functional equivalents.
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| Gene associated with arteriosclerotic disease, and use thereof | 20090324610 | 20091231 |
| Two genes implicated in arteriosclerotic diseases such as cerebral infarction were successfully identified by performing genome-wide correlation studies using SNPs by targeting the entire genome. Polymorphic mutations that can be used to examine the presence or absence of risk factors for arteriosclerotic diseases were successfully found on the genes. Subjects can be efficiently examined for the presence or absence of risk factors for arteriosclerotic diseases using the presence or absence of the polymorphic mutations as indicators. Furthermore, methods of screening for therapeutic agents for arteriosclerotic diseases are enabled by using expression or function of the genes as index.
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| Encryption device, program, and method | 20090323956 | 20091231 |
| Disclosed is an encryption device for generating a pseudo-random number based on a secret key and generates an encrypted text by applying the pseudo-random number sequence to a plain text, uses, an internal state in accordance with a state based on a permutation of a sequence of a finite number of numeric values, as an internal state used for generation of the pseudo-random number sequence, executes a predetermined leftward or rightward rotate shift, depending on a number smaller than an internal state number, based on the result of linear or non-linear, or combination of linear and non-linear using one or more numeric values of the internal state and sets at least one temporary variable used for generation of the pseudo-random number sequence to be a temporary... |
| Power conversion device | 20090322276 | 20091231 |
| A power conversion device includes a main circuit that has switches connecting each phase of a three-phase AC power supply to each output phase, an LC filter having a reactor and a capacitor connected between the three-phase AC power supply and each bidirectional switch, and a current detector detecting an input current or a load current, and a four-step commutation device generating four steps on the basis of the polarity of the load current. The four-step commutation device sets times between the steps to a value more than zero so as to inhibit open circuit between output phases and short circuit between power supply phases, and sets the times between the steps in accordance with the polarity of the load current so as to cancel a... |
| Motor controller with hall sensor output misalignment compensation using delayed or shifted commutation | 20090322267 | 20091231 |
| In a normal operating mode, a motor controller provides motor drive current to windings of a motor based on sensor signals to drive the windings in a normal commutation sequence, and monitors for occurrence of a motor stall condition. Upon detecting the motor stall condition in a given commutation state, then in a first driving step, the windings are momentarily driven according to an advanced commutation state, and during the first driving step, a reverse transition of the sensor signals to a state corresponding to a preceding commutation state is detected. Upon completion of the first driving step when such a reverse transition of the sensor signals is detected, then in a second driving step the windings are driven according to the preceding commutation state until... |
| Systems and methods for controlling a dc motor | 20090322266 | 20091231 |
| Various systems and methods for controlling DC motors are disclosed herein. For example, one method provides for controlling a polyphase, brushless DC motor. The method includes providing a DC motor that has a plurality of phases. Such a DC motor operates by inducing a current in the plurality of phases in accordance with a plurality of commutation states. In the example, six commutation states are discussed, but fewer than or more than six commutation states may exist. The method further includes initializing a count, inducing a current in the plurality of phases in accordance with a first commutation state, and incrementing the count until the current achieves a threshold in the first commutation state. Then, a current is induced in the plurality of phases in accordance... |
| Mutation breeding for resistance to disease and other useful traits | 20090320152 | 20091224 |
| Particular aspects provide novel mutant plants and plant parts thereof, derived via mutagenesis, having disease resistance and other useful traits. Particular embodiments provide a wheat genotype ‘RRR Scarlet’ (‘Scarlet-Rz1’), plants and seeds thereof, methods for producing a plant comprising crossing ‘Scarlet-Rz1’ plants with another wheat plant, hybrid wheat seeds and plants produced by crossing ‘Scarlet-Rz1’ plants with another line or plant, and creation of variants by mutagenesis or transformation of ‘Scarlet-Rz1’. Additional aspects provide methods for producing other varieties or breeding lines derived from ‘Scarlet-Rz1’ and to varieties or breeding lines produced thereby. Further aspects provide for mutant plants and plant parts thereof that are resistant and/or tolerant to plant root fungal pathogens such as Rhizoctonia and Pythium. Additional embodiments provide mutant plants and plant parts... |
| Method for treating cancer harboring egfr mutations | 20090318480 | 20091224 |
| The present invention relates to a method of treatment of patients suffering from cancer and harbouring mutations of EGFR in the tumour, for instance an activating mutation of the EGFR or a mutation responsible for resistance or the emergence of acquired resistance to treatment with reversible EGFR and/or HER2 inhibitors or irreversible inhibitors such as CI-1033, EKB-569, HKI-272 or HKI-357, comprising administering an effective amount of the irreversible EGFR inhibitor BIBW2992 (1) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline, to a person in need of such treatment, optionally in combination with the administration of a further chemotherapeutic agent, in combination with radiotherapy, radio-immunotherapy and/or tumour resection by surgery, and to the use of a BIBW 2992 (1) for preparing a pharmaceutical composition for the treatment of patients suffering from cancer and harbouring... |
| Highly diversified antibody libraries | 20090318308 | 20091224 |
| The present invention provides an in vitro method for obtaining a library of polynucleotides encoding antibodies, derivatives thereof or fragments thereof, comprising the step of performing random mutagenesis of a polynucleotide encoding the variable region of a heavy chain and/or the variable region of a light chain of a light chain, wherein random mutagenesis is performed on a library of polynucleotides comprising a sequence encoding the variable region of a heavy chain and/or the variable region of a light chain; and wherein the random mutagenesis process creates randomly distributed mutations along at least 70% of the sequence encoding the variable region.
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| Mutations in ion channel proteins associated with sudden cardiac death | 20090317905 | 20091224 |
| Previously unknown mutations of the KCNH2, SCN5A and KCNQ1 genes are disclosed which are involved in ion channel disruptions associated with short QT syndrome, long QT syndrome, Brugada syndrome and progressive conduction disease. These mutations are utilized to diagnose and screen for short QT syndrome, long QT syndrome, Brugada syndrome and progressive conduction disease, thus providing modalities for diagnosing sudden cardiac death and/or predicting susceptibility to sudden cardiac death. Nucleic acid probes are provided which selectively hybridize to the mutant nucleic acids described herein. Antibodies are provided which selectively bind to the mutant proteins described herein. The mutations described herein are also utilized to screen for compounds useful in treating the symptoms manifest by such mutations.
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| Eubacterial rna-polymerase mutants with altered product production | 20090317865 | 20091224 |
| The present invention relates to an isolated mutant eubacterium comprising at least one mutation resulting in a substitution of at least one amino acid in the beta-subunit of the RNA-polymerase encoded for by the rpoB-gene providing an altered production of a product of interest when said production of a product of interest is compared to the production of the same product in an isogenic wild type strain grown at identical conditions, wherein the substitution of at least one amino acid occurs at any of positions 469, 478, 482, 485, or 487 of SEQ ID NO:2, or at the equivalent positions in any eubacterial RNA-polymererase beta-subunit family member. Another aspect of the invention relates to a process for producing at least one product of interest in a... |
| Alpha-amylase mutants | 20090317864 | 20091224 |
| The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an alpha-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an alpha-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an alpha-amylase variant of the invention, a method for generating... |
| Mutations in capillary morphogenesis gene-2 (cmg-2) and use thereof | 20090317823 | 20091224 |
| Mutations and polymorphisms in a particular gene, the capillary morphogenesis gene-2 (CMG-2) have been identified. The mutations have been associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF), as well as conditions associated with these disorders. Described herein are variant CMG-2 nucleic acids and variant CMG-2 polypeptides; cells comprising such variant CMG-2 nucleic acids and/or expressing variant CMG-2 polypeptides; and methods of diagnosing and treating such disorders and conditions. Variant CMG-2 proteins include those comprising one or more of E220X, G105D, L329, P257insC, I189T, A357P, and A322S. Variant CMG-2 nucleic acids include those encoding these mutant CMG-2 proteins, as well as silent mutations or polymorphisms.
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| Method of detecting preeclampsia | 20090317812 | 20091224 |
| The invention provides a method for detecting a propensity toward or risk of developing preeclampsia, comprising detecting in a female subject the presence of a single base pair point mutation, ΔA at position +1754, in the HLA-G mRNA 3′UTR. The mutation is associated with preeclampsic subjects, and with decreased RNA stability in vitro. The presence of this ΔA mutation may provide an explanation for lower levels of HLA-G expression seen in association with preeclampsia.
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| Reporter vector for use in evaluation of cyp1a2 induction | 20090317800 | 20091224 |
| A reporter vector which can evaluate the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 and a method for evaluation of the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 by using the reporter vector. A reporter system which can evaluate the ability of a drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 is completed by constructing a reporter vector having a reporter gene linked to the 3′ end of a region between CYP1A1 and CYP1A2 or a reporter vector having different reporter genes linked to the both ends of the region, respectively, so as to sandwich the region, and a reporter vector having a deletion mutation in the region, and confirming that... |
| Vaccines and methods for prevention and treatment of drug-resistant hiv-1 and hepatitis b virus | 20090317418 | 20091224 |
| The present invention provides methods for lowering a viral load of a virus resistant to an antiviral drug by inducing cytotoxic T lymphocytes (CTL) to recognize a predetermined mutated epitope within a viral protein of the drug-resistant virus. CTLs are induced by immunizing a host with a peptide comprising the predetermined mutation. The immunostimulating peptide may be further improved by epitope-enhancement for inducing specific CTLs. The antiviral protection against drug-resistant virus shown by compositions of the present invention and mediated by human HLA-restricted CTL has not been previously achieved.
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| method of atomic transformation | 20090317281 | 20091224 |
| This invention provides a method for atomic transformations carried out under conditions akin to chemical catalysis. Liquid and solid state catalysts are used in a two-step process. We have found that the high ionic/electric activity of concentrated sodium hydroxide solution in combination with heating is sufficient to induce atomic transformation and provide a solid phase catalyst of high aluminum and silicon content. This product when heated at a temperature of 1000° C. yields numerous elements of higher atomic masses. Thus, atomic transformation (transmutation) is demonstrated by using common chemicals and simple laboratory procedures
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| Power supply abnormality detection circuit for on-vehicle electronic control device | 20090316320 | 20091224 |
| The on-vehicle electronic control device includes a main power supply circuit fed with power from an on-vehicle battery through an output contact of a power supply relay and a main power supply terminal of a connector to supply a stabilized control voltage to a microprocessor. When contact failure occurs in the main power supply terminal, the main power supply circuit is fed with bypass power from the output contact through a first electrical load and a commutation diode to perform the one of the report of the abnormality and the storage of the abnormality occurrence history information. A bypass power fed state is detected when an input voltage to the main power supply circuit is lower than a power supply voltage of the on-vehicle battery.
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| Motor control unit and air conditioner having the same | 20090315492 | 20091224 |
| A motor control unit or a semiconductor integrated circuit device for an air conditioner is provided. The motor control unit includes a current detector that detects a coil wound current of the permanent magnet motor; a coordinate transformer that transforms the coil wound current detected by the current detector into a d-axis current indicating a magnet flux component and a q-axis current indicating a torque component perpendicular to the magnet flux component; a position estimator that estimates a rotational position of the rotor based on an induced voltage of the permanent magnet motor; a current controller that calculates a command d-axis voltage based on a command d-axis current and the d-axis current detected by the current detector, and that calculates a command q-axis voltage based on... |
| Electric motor | 20090315491 | 20091224 |
| An electric motor has a DC link circuit (30, 32), a permanent-magnet rotor (104), and a control circuit having a full bridge (114). A program-controlled calculation arrangement (80) is configured to supply the semiconductor switches of a first bridge half with a PWM signal (136, 136′) and to supply the semiconductor switches (118, 122) of the second bridge half with a commutation signal (O1, O2; 150, 150′). An energy storage device (170) is provided which, during normal operation of the motor (102), is chargeable from the DC link circuit (30, 32) and serves, upon cessation of the signals from the calculation arrangement (80), to make the semiconductor switches (118, 122) of the other bridge half conductive, and thereby to short-circuit the stator winding arrangement (106) through... |
| Gibberellin 2-oxidase genes and uses thereof | 20090313725 | 20091217 |
| Novel gibberellin 2-oxidase (GA2ox) genes were identified. Differential expression of GA2ox genes correlated with flower development, seed germination, tiller growth and other developmental processes. In addition, the early and increased growth of tiller and adventitious root and altered root architecture caused by overexpression of GA2oxs further suggest the pleiotropic role of GA2oxs in controlling growth and architecture in plants such as rice. GA2ox5, GA2ox6 and GA2ox9 were three genes encoding class C20 GA2oxs in rice. Mutants or transgenic rice overexpressing class C20 GA2oxs exhibited a broad range of mutant phenotypes, including semi-dwarfism, increased root system and higher tiller numbers that may favor grain yield. Mutations in the conserved domain III were found to affect the physiological activity of class C20 GA2oxs.
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| Hardware design using evolution algorithms | 20090313191 | 20091217 |
| The design of a hardware component such as a digital filter is optimized by taking an initial population of filter designs and encoding them as chromosomes. The fitness of each chromosome is then evaluated and parent chromosomes are then selected based on the fitness criteria. Offspring chromosomes are then generated using genetic operations such as mutation and cross-over from the pool of offspring, and optionally, parents. Individuals are selected to survive using a combination of Pareto fronts based on non-dominated individuals and clustering. The process is repeated or until a termination criteria is satisfied.
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| Fulfilling demand for particular blood group types | 20090313042 | 20091217 |
| Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to... |
| Pharmacological chaperones for treating obesity | 20090312345 | 20091217 |
| The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface.
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| Compounds for the treatment of spinal muscular atrophy and other uses | 20090312323 | 20091217 |
| Compounds of Formula (I) or (II) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.
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| Method of directing the evolution of an organism | 20090311790 | 20091217 |
| The present disclosure relates to a method of directing the evolution of an organism by modifying the mutation rate of an organism. The increase in genetic diversity may be used to facilitate the selection of a desired hereditary trait in an organism.
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| Apparatus, methods and products for detecting genetic mutation | 20080318215 | 20081225 |
| Methods for detecting genetic mutation allowing detection of very low frequency mutation. Methods comprise treating RNA:DNA heteroduplexes of interest with ribonuclease treatment coupled with DNA polymerase treatment. RNA:DNA heteroduplexes of interest are preferentially targeted for digestion by ribonuclease and subsequent sequence extension by DNA polymerase. Methods may be carried out partially or entirely manually, automatically, and combinations thereof. Methods may be performed wholly or partially in solution, on solid phase media, in large scale, adapted for high throughput analysis, and any combinations thereof. Apparatus and products for detecting genetic mutation.
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| Source tagging and normalization of dna for parallel dna sequencing, and direct measurement of mutation rates using the same | 20080318233 | 20081225 |
| This invention allows efficient tagging and normalization of DNA molecules prior to pooling and characterization using parallel DNA sequencing (e.g., commercially available 454 sequencers). The invention provides novel ways to process independent DNA samples (sources) so that similar numbers of molecules from each source are represented in the pool (i.e., the pool is normalized for representation among the sources). These approaches would save researchers time and energy relative to approaches currently available. In other embodiments, the invention provides novel ways to process large numbers of independently derived DNA samples that can be uniquely tagged in ways that allow the source of the DNA (e.g., an individual) to be tracked. The invention also provides novel ways for processing DNA to consistently obtain various portions of the genome... |
| Method of detecting gene mutation | 20080318238 | 20081225 |
| DNA amplification and hybridization are successively carried out in a reaction system containing primers for the DNA amplification and hybridization probes, followed by detecting the hybrid in the reaction solution by affinity chromatography, wherein at least one of the primers to be used in the DNA amplification is labeled with a first labeling agent so that the amplified DNA will be labeled with the first labeling agent, a hybridization probe is labeled with a second labeling agent and contained in a reaction solution for effecting the DNA amplification, the base sequence of the hybridization probe is designed not to inhibit the DNA amplification, and a hybrid is detected by affinity chromatography with the use of the first and second labeling agents.
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| Ammonia-specific 5'-xmp aminase mutant | 20080318278 | 20081225 |
| Disclosed herein are ammonia-specific 5′-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5′-XMP aminase. The resulting 5′-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5′-XMP into 5′-GMP. Thus, the ammonia-specific 5′-XMP aminase mutant is stabler within cells compared to the wild type, and can be useful in the industrial conversion of 5′-XMP into 5′-GMP.
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| Mutant glycoprotein resistant to modification with asparagine-linked sugar chain | 20080318296 | 20081225 |
| To obtain a mutant protein of an asparagine-linked glycoprotein, which has no N-linked sugar chain under ordinary circumstance, and remains a physiological activity of the glycoprotein before the mutation was introduced, at least one of the amino acids contained in the amino acid sequence motif (I) and/or (II) in the polypeptide of the asparagine-linked glycoprotein is substituted into another amino acid: (I) Asn Xa1 Xa2 (II) Xa3 Val Gly Asn Xa1 Xa2. In amino acid sequence motif (I) and (II), Xa1 represents an amino acid other than Pro, Xa2 represents Thr or Ser and Xa3 represents His or Asp.
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| Methods for generating hypermutable microbes | 20080318321 | 20081225 |
| Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficiency and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch repair activity to the bacteria.
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| Es cell mutation method and system | 20080318804 | 20081225 |
| This is intended to provide a technique for providing a stem cell having a mutation in both alleles (a pair of alleles). A method for producing a stem cell having a mutation in both chains of alleles which comprises: A) the step of providing a stem cell; B) the step of preventing Blm alleles from functioning in the stem cell; and C) the step of inducing mutation in the stem cell. It is also intended to provide a library of stem cells having a mutation in both chains of alleles wherein stem cells involved in the library have the mutation transferred thereinto over the entire genome.
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| High activity growth factor mutants | 20080318860 | 20081225 |
| The application relates to novel biosynthetic growth factor mutants, derived from GDF-5, which exhibit improved biological activity. Mutations at positions 453 and 456 of human GDF-5 are disclosed, as well as use of these mutants in therapy of diseases associated with tissue degeneration/destruction.
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| Method and system for identifying proximity areas between several digitally simulated geometrical objects | 20080319718 | 20081225 |
| (a) first memory (111) for storing data describing the geometry of the objects, (b) an initialization module (120) for creating a population of pions, and (c) a central processor unit (140) comprising at least: (c1) a unit (141) for selecting a percentage of the population of pions to be subjected to combats in pairs, (c2) a comparison and calculation unit (142) for evaluating the quality of each of the pions in each pair of pions subjected to a combat, (c3) a marking unit (143) for identifying in each session of the tournament which of the pions of a pair of pions subjected to a combat has won or lost, (c4) an iteration unit (144) for causing the pions that have been subjected to at least one... |
| Method for the construction and utilization of a medical records system | 20080319800 | 20081225 |
| A method for the construction and utilization of a medical records system capable of providing a continuous data stream of epidemiological data to the records system via kits provided to the symptomatic population to obtain and record an epidemiological profile in a searchable database by applying data mining or automated intelligence techniques whereby, when a valid epidemiological profile is established in the database, automated diagnosis and prescription of treatment may be had for patients presenting similar symptoms. Knowledge discovery techniques may further operate on the database to provide suggested courses of treatment for a virtual class of patients, epidemic threat awareness, and knowledge of drug resistance mutations by a pathogen without direct query of the database.
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| Method and apparatus for document clustering and document sketching | 20080319941 | 20081225 |
| A first embodiment of the invention provides a system that automatically classifies documents in a collection into clusters based on the similarities between documents, that automatically classifies new documents into the right clusters, and that may change the number or parameters of clusters under various circumstances. A second embodiment of the invention provides a technique for comparing two documents, in which a fingerprint or sketch of each document is computed. In particular, this embodiment of the invention uses a specific algorithm to compute the document's fingerprint. One embodiment uses a sentence in the document as a logical delimiter or window from which significant words are extracted and, thereafter, a hash is computed of all pair-wise permutations. Words are extracted based on their weight in the document,... |
| Microcontroller interface with hall element | 20080309269 | 20081218 |
| A device controller system incorporates an inexpensive Hall element to detect motion of a brushless DC motor. A magnet, which is part of a motor rotor, passes by the Hall element producing a Hall voltage each rotation. The Hall voltage is coupled through an interface port to a comparator within a process controller. A microprocessor within the process controller calculates a control response based on a comparator output signal. The interface port is rapidly configured to provide signals produced from the control response as output to device drivers on the same input-output pins that receive the Hall voltage. The device drivers produce a current through fan coils producing an update in the magnetic field of each motor phase which updates the speed of the fan according... |
| Anti-tissue factor antibodies and compositions with enhanced effector function | 20080311034 | 20081218 |
| Variants of antibodies to human tissue factor are optimized for the capability to elicit effector functions produced by immune effector cells while maintaining the ability to neutralize the biological functions of tissue factor, such as the prevention of blood clotting via the extrinsic pathway, and are produced by mutations of the Fc-region of the antibody. The variants comprise A330Y, A330I, and I332E where the I332E variant may optionally further comprise a second substitution selected from A330I (in the case of the first substitution being I332E), V264I, and S239D. The variants may further be optimized for the capability to elicit effector functions produced by immune effector cells by production of the antibody variants under conditions that produce effector function enhancing glycosylation of the Fc-region.
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| Ilt3 polypeptides and uses thereof | 20080311073 | 20081218 |
| This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods... |
| Novel missense mutations and single nucleotide polymorphisms in the rabphillin-3a-like gene and uses thereof | 20080311574 | 20081218 |
| The invention relates to methods and compositions of matter for determining or predicting aggressiveness of a subject's tumor, for determining a subject's predisposition to cancer, for diagnosing cancer in a subject, and for selecting a therapy for a subject with cancer. Also provided are methods and compositions of matter for determining a Rabphillin-3A-Like gene genotype in a subject and for characterizing a Rabphillin-3A-Like gene in a subject.
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| Methods for detection of mutations in myostatin variants | 20080311584 | 20081218 |
| Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to produce food products, including bovine, porcine, ovine, avian and piscine species.
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| Mutated aqp, method for detecting cancer using the same, dna chip having oligonucleotides of said mutated aqp sequence | 20080312094 | 20081218 |
| The present invention relates to mutation genes of the AQP (aquaporin), a method for detecting cancer using mutations and expressions of the AQP and a DNA chip possessing oligonucleotides of mutated AQP base sequence. In case of the present method for detecting cancer and DNA chip using the AQP's mutations and expressions, it is highly accurate, rapid and effective in cancer diagnosis.
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| Human g-protein receptor hgber32 | 20080312178 | 20081218 |
| Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
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| Cadasil treatment with cholinesterase inhibitors | 20080312189 | 20081218 |
| The invention provides methods for treating and/or preventing cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in a patient in need thereof by administering a therapeutically effective amount of at least one cholinesterase inhibitor. The invention also provides methods for treating and/or preventing neurovascular diseases caused by one or more mutations of the human Notch3 gene by administering a therapeutically effective amount of at least one cholinesterase inhibitor. In one embodiment, the cholinesterase inhibitor is donepezil, a stereoisomer thereof and/or a pharmaceutically acceptable salt thereof. The methods of the invention may further include administering a therapeutically effective amount of an HMG-CoA reductase inhibitor
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| Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway | 20080312267 | 20081218 |
| The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
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| Method and system for evaluating multi-dimensional project plans for implementing packaged software applications | 20080313596 | 20081218 |
| A method for scoring and ranking multi-dimensional project plans for implementing packaged software applications, the method includes: determining one or more dimensions for a project plan; assigning one or more attributes to each of the one or more dimensions; assigning one or more utility functions to each of the one or more attributes; assigning one or more weights to each of the one or more attributes; assigning one or more ordering factors to one or more combinations and permutations of the dimensions; calculating a series of scores for the one or more combinations and permutations of the dimensions; ranking the one or more combinations and permutations of the dimensions based on the calculated series of scores; and wherein each of the one or more combinations and... |
| Method for generating hypermutable organisms | 20080313754 | 20081218 |
| Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation.
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| Method and circuit arrangement for determining the rotor position of an ec motor in the standstill state | 20080303516 | 20081211 |
| The invention relates to a method and a circuit arrangement for determining the position of the rotor of an electronically commutated motor having a plurality of stator phases, whose rotor has magnetic axes having different permeances. Voltage is applied to the stator phases, and the resultant phase currents are monitored for the purpose of determining the rotor position in the standstill state of the motor. For this purpose, first and second rise times of the phase currents are determined until predetermined limit values are reached on the one hand in the unsaturated state, and on the other hand using saturation effects of the rotor core and/or stator core. The assignment of a magnetic axis to a stator phase is determined from the first rise times of... |
| Novel methods of cancer diagnosis and therapy targeted against a cancer stem line | 20080305107 | 20081211 |
| Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.
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| Marked bovine viral diarrhea virus vaccines | 20080305130 | 20081211 |
| The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.
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| Method and apparatus for using slc2a10 genetic polymorphisms for determining peripheral vascular disease in patients with type-2 diabetes | 20080305474 | 20081211 |
| Recent data indicate that a loss-of-function mutation of the SLC2A10 gene causes arterial tortuosity syndrome (ATS) via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes associated with diabetes. It is determined that SLC2A10 (Solute carrier family 2, facilitated glucose transporter, member 10) genetic polymorphism is associated with peripheral vascular disease (PVD) in patients with type 2 diabetes.
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| File mutation method and system using file section information and mutation rules | 20080307006 | 20081211 |
| Provided are a file mutation method and a system using file section information and mutation rules. The file mutation system includes: a file section information extraction module obtaining file section information with respect to a sample file of a known file format; a file section information production module producing file section information with respect to a sample file of an unknown format; a mutation rule production module receiving a user input that a mutation rule is applied and producing a mutation rule, the mutation rule defining a mutation function that is to be applied to each data type; and a file mutation module receiving the sample file and producing a plurality of test case files that are created by mutating the sample file through the file... |
| Disease resistant cucumber plants | 20080307540 | 20081211 |
| markers E16/M50-F-194, E11/M48-F-251, E23/M38-M001, E23/M40-M003, E24/M46-M002, E24/M46-M003, E12/M91-M003, E26/M43-M003, E14/M59-F-134 and E14/M59-F-200.
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| Single-sensor based commutation of multi-phase motor | 20080297083 | 20081204 |
| System, method, and apparatus for commutating and controlling a multi-phase motor using one output rotor sensor and circuitry that measures time between rotor pole-to-pole transitions is disclosed. The exemplary system, method, and apparatus may utilize the polarity of the single-output rotor sensor and the measured time between the polarity transitions detected by the single-output rotor sensor.
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| Control circuit for an electronically commutated motor | 20080297084 | 20081204 |
| A control circuit for an electronically commutated motor (120), having a power stage (122) that comprises at least two semiconductor switches (216, 218) to influence the motor current. The semiconductor switches are controllable by way of commutation signals. The control circuit comprises a current measuring element (170) to make available a motor current control variable (I) dependent on the motor current, a base diode (240) that is arranged in series with the current measuring element and between the current measuring element and the at least two semiconductor switches, and a motor current setting element (180) with which the commutation signals can be influenced as a function of the motor current control variable.
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| Method for operation of a high pressure discharge lamp operating device for a high pressure discharge lamp and high pressure discharge lamp with an operating device | 20070296349 | 20071227 |
| The invention relates to a method and a device for operation of ah high pressure discharge lamp with a low-frequency current of alternating polarity, whereby the high pressure discharge lamp is operated during a start phase at a higher power than the rated power thereof. According to the invention, the high pressure discharge lamp is provided with a current, at least during the start phase, with a commutation time of less than or equal to 40 microseconds.
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| Prevention of concurrent pwm or psm commutations of power signals driving a voice coil motor (vcm) to reduce s/n ratio degradation of low level signal lines of a r/w head | 20070296362 | 20071227 |
| A method of preventing concurrent or quasi-concurrent commutations of a pair of phase shift modulation (PSM) drive signals of an output bridge stage driving an electrical load includes establishing a threshold level of a programmed current level to be transmitted though the electrical load. The method also includes, if the programmed current level is lower than the threshold level, enhancing a time offset between commutation edges of the pair of PSM drive signals by a minimum time.
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| Method for optimizing probe card design | 20070296438 | 20071227 |
| A method is presented of designing semiconductor probe cards to have the optimum number and placement of die probe sites for function testing integrated circuit (IC) die at semiconductor wafer test, while minimizing the number of times the probe card must be moved (number of “touchdowns”) to test all the IC die on a semiconductor wafer, as well as minimizing the number of individual IC die on the wafer that are probed more than once during the wafer test. Each specific arrangement of probe sites is tested against other patterns for efficiency in testing in what is known as a genetic algorithm. The most efficient patterns are moved into the next generation with modified features obtained by crossovers between two efficient individuals, and with random mutations,... |
| On-vehicle apparatus theft deterrence system | 20070296563 | 20071227 |
| A navigation apparatus is detachably installed to a vehicle and is lockable to implement activation lock of the navigation apparatus. The navigation apparatus stores all of manufacturer serial numbers of wireless IC tags and an ID code. Each IC tag stores the ID code and is attached to a corresponding one of portable items, such as a driver's license, a cellular phone, a wallet and a commutation pass, which are generally used daily. In the navigation system, the manufacturer serial numbers are registered in such a manner that each of manufacturer serial numbers is linked with an icon of a corresponding one of the portable items. When the ID code of the IC tag, which is attached to the corresponding portable item carried by a vehicle... |
| Method and system for production of radioisotopes, and radioisotopes produced thereby | 20070297554 | 20071227 |
| A system and method for the production of radioisotopes by the transmutation of target isotopic material bombarded by a continuous wave particle beam. An ion source generates a continuous wave ion beam, irradiating an isotope target, which is cooled by transferring heat away from the target at heat fluxes of at least about 1 kW/cm2.
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| Integrated optical circuits having drop-in locations for optical circuit elements | 20070297715 | 20071227 |
| A plurality of mask images defines an optical circuit image in photoresist. Each of the mask images comprises parts of the optical circuit and the totality of all mask images together defines an optical circuit. The optical circuit is thus made up of plural optical elements some of which may be positioned in drop-in locations within the boundary of another optical circuit element. A photolithography system globally aligns and exposes the mask images in photoresist. The resultant composite image is substantially indistinguishable from a single image of the entire optical circuit. Different images for each of the mask image parts can be substituted with other images or image parts and thereby exponentially increasing the number of circuit permutations from a predetermined number of available mask images.... |
| Tumor necrosis factor-gamma | 20070297977 | 20071227 |
| Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
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| Highly safe smallpox vaccine virus and vaccinia virus vector | 20070298054 | 20071227 |
| Objects of the present invention are to generate vaccine strains that undergo reversion (atavism) with difficulty and to provide smallpox vaccines with higher safety. The vaccine viruses are deficient in a part or the whole of the B5R gene of a vaccinia viral strain, LC16m8 or LC16mO, and produce no B5R gene products having normal functions. The vaccine viruses can be used as smallpox vaccines or vectors capable of expressing foreign genes. Hence, smallpox vaccines and vaccinia virus vectors are provided that produce no B5R gene products having normal functions due to reverse mutation.
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| K-ras oligonucleotide microarray and method for detecting k-ras mutations employing the same | 20070298419 | 20071227 |
| Since the K-ras oligonucleotide microarray of the present invention can detect K-ras mutations by applying a competitive DNA hybridization method to the oligonucleotides spotted on a solid matrix different from the previously reported method for detecting a mutation, it makes the more precise analysis and can reduce experimental cost and time. Accordingly, the K-ras oligonucleotide microarray of the present invention can be used in studies to detect K-ras mutations and unravel the signal transduction mechanism and tumorigenesis related to K-ras gene. Further, since the microarray of the present invention can be applied to other genes having mutational hot spot regions such as K-ras, it has wide applicable range.
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| Calpastatin markers for fertility and longevity | 20070298421 | 20071227 |
| Aspects of the present invention provide novel compositions and methods based on novel calpastatin (CAST) genetic markers, such as missense mutations in exon 3 that result in G48D or P52L substitutions (NM_174003.2:c.271G>A and 283C>T), a G/T substitution in intron 3 (AAFC02060381.1:g.2110G>T) and a GAAA repeat in intron 8 (AAFC02060381.1:g.6700[(GAAA)4]+[(GAAA)5]. Particular aspects provide novel markers for fertility (e.g., daughter pregnancy rate, DPR) and longevity (e.g., productive life, PL) in, for example, dairy cattle. Additional aspects provide for novel methods comprising marker-assisted selection to improve fertility and/or longevity in dairy cattle. Therefore, in particular embodiments, a combination of genetic selection based on one or more of the novel CAST markers, and high PTA potentials of milk production traits, provides for improved reproductive traits in association with continued high... |
| Method of monitoring colorectal cancer | 20070298431 | 20071227 |
| A method and kit is described for individualized stool surveillance for occurrence/recurrence of preneoplastic or neoplastic lesions based on the analysis of genetic mutations and methylation pattern detected in biopsy tissue removed during polypectomie as compared to normal colon mucosa.
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| Method for detecting the risk of cardiovascular diseases such as acute myocardial infarction and coronary heart disease by analysing defesin | 20070299025 | 20071227 |
| The invention provides a method of identifying subject's susceptibility or predisposition to or risk of developing cardiovascular diseases such as myocardial infarction (MI) or coronary heart disease (CHD) by detecting gene polymorphisms and other gene mutations in a defensin gene from a biological sample of the subject and obtaining information concerning the family and medical history, blood, serum, plasma and urinary analytes of the subject. The invention also provides a multivariate model, a combination or algorithm of variables which best describes the probability of CHD, especially MI. The invention also relates to a test kit and software for accomplishing the method. The present invention also relates to a variant defensin gene.
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| Methods for encrypting and compressing video | 20070291941 | 20071220 |
| A method for compressing and transmitting a sequence of video frames represented by arrays of digital pixel values includes the following steps: transmitting a representation of a first frame (I1) of the sequence; deriving a sorting permutation P1 of the first frame; using the sorting permutation of the first frame, P1, to approximately sort a second frame (I2) of the sequence, to obtain approximately sorted frame P1(I2); and compressing and transmitting the approximately sorted frame P1(I2).
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| Replication competent hepatitis c virus and methods of use | 20070292840 | 20071220 |
| The present invention provides replication competent polynucleotides that include a coding sequence encoding a hepatitis C virus polyprotein having adaptive mutations. The invention also includes methods for malting replication competent polynucleotides, identifying a compound that inhibits replication of a replication competent polynucleotide, selecting a replication competent polynucleotide, and detecting a replication competent polynucleotide.
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| Fluorescent protein | 20070292909 | 20071220 |
| An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can be obtained by the maximum excitation. The present invention provides a novel fluorescent protein monomerized by introducing a mutation into a florescent protein derived from Fungia sp., and a novel chromoprotein and fluorescent protein derived from Montipora. sp.
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| Mutant protein having the peptide-synthesizing activity | 20070292916 | 20071220 |
| The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2. (II) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations L1 to L335 and M1 to M642 in an amino acid sequence of SEQ ID NO:208
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| Chimeric cancer models | 20070292948 | 20071220 |
| Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells into an early stage embryo, and then implanting the manipulated embryo into a surrogate mother. The ES cells contain a recombinant oncogene, and also may contain a genetic mutation that deletes or inactivates a tumor suppressor gene. Models of different types of cancer are produced by introducing different combinations of genetic mutations into the ES cells that are introduced into the early stage embryo.
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| Method for distinguishing aml-specific flt3 length mutations from tkd mutations | 20070292970 | 20071220 |
| Disclosed is a method for distinguishing AML-specific FLT3 length mutations from TKD mutations in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.
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| Method and system for comparative genomics | 20070294038 | 20071220 |
| A method and system for representing a similarity between at least two genomes that includes detecting gene clusters which are common to the at least two genomes and representing the common gene clusters in a PQ tree. The PQ tree includes a first internal node (P node), that allows permutation of the children thereof, and a second internal node (Q node), that maintains unidirectional order of the children thereof.
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| Methods for generating genetic diversity by permutational mutagenesis | 20070294785 | 20071220 |
| Methods for generating genetic diversity in a polynucleotide or polypeptide sequence are included. The methods include permutational mutagenesis strategies for introducing genetic diversity to alter or improve the function of the polynucleotide or polypeptide. The methods include aligning a set of homologous sequences and generating a consensus translation or a consensus sequence that encompasses the full diversity of the aligned sequences, and then incorporating that consensus translation or consensus sequence into a functional polypeptide or polynucleotide to test for altered or improved function.
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| Solar circulation pump and method for controlling a solar circulation pump, for controlling the starting of and for setting the performance of a solar circulation pump | 20070285039 | 20071213 |
| To provide a solar circulation pump for connection to a photovoltaic panel device, comprising an electric motor which is electronically commutated and has a control device for supplying a periodic commutation signal, it is proposed that the control device be so configured that the commutation signal is varied with respect to the ratio of switch-on time to switch-off time.
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| Combination therapy | 20070286867 | 20071213 |
| The invention provides combination therapies and methods for the treatment of cancers associates with p53 mutations. The method comprises the separate, sequential or simultaneous administration of a therapeutically effective amount of a) a specific binding member, for example CH-11, which binds to a cell death receptor, for example Fas, or a nucleic acid encoding said binding member and b) a chemotherapeutic agent, wherein the chemotherapeutic agent is a topoisomerase inhibitor, for example CPT-1 or a thymidylate synthase inhibitor, for example TDX. Synergistic cytotoxic effects have been demonstrated using such combinations.
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| Power tool with dynamic and mechanical brake | 20070287365 | 20071213 |
| A power tool in accordance with an embodiment of the invention has a motor driving a member, a switch coupled across windings of the motor that dynamically brakes the motor, and a mechanical brake that brakes speed of the member. In an aspect, the combined dynamic and mechanical braking brakes speed of the member to a desired speed in no more than about two second. In an aspect, the motor is an electronically commutated motor and the power tool includes a controller that electronically commutates the motor by switching switches that switch power to the motor in an electronic commutation sequence and switches the switches to electronically brake the motor.
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| Method for mutation detection in hiv-1 using pol sequencing | 20070287834 | 20071213 |
| The present invention relates to a method for mutation analysis of the HIV pol gene of HIV-1 virions comprising amplifying virion RNA or DNA via nested PCR using outer primers as represented in SEQ ID No. 1 and 2, amplifying said PCR product via nested PCR using a 5′ and 3′ primer chosen from the inner primers SEQ ID No. 3, 4, 5 and 6, and sequencing this secondary obtained PCR product using at least one sequencing primer chosen from any of SEQ ID No. 7 to 12 or variants thereof. In the alternative, at least one secondary sequencing primer may be used chosen from any of SEQ ID No. 13 to 24. The present invention also relates to kits for performing such a method as... |
| High-voltage direct-current transmission device | 20070279947 | 20071206 |
| A device for the transmission of a high-voltage direct current has a supply connection terminal for connecting an alternating current network that supplies energy and a consumer connection terminal for connecting a multi-phase consumer. A rectifier is connected downstream of the supply connection terminal, the rectifier is connected to an inverter by way of a direct-current intermediate circuit that includes a smoothing element. The alternating current side of the inverter is connected to the consumer connection terminal. The rectifier and the inverter include thyristor valves and a control unit drives the thyristor valves of the inverter in accordance with a clock pulse. The device enables power to be supplied to passive consumers such as stand-alone networks. For that purpose, the control unit is connected to a... |
| Apparatus for demodulating address in pre-groove symbols and apparatus for decoding pre-pit symbols | 20070280072 | 20071206 |
| The invention provides an apparatus for demodulating an Address In Pre-groove (ADIP) symbol. The ADIP symbol is carried by a wobble signal of an optical disk and comprises a series of ADIP bits permuted according to one of a plurality of permutation patterns to make up the ADIP symbol. A wobble extraction module extracts the wobble signal from the optical disk. A reference wobble generator generates a reference wobble with the same frequency and phase as a fundamental frequency and phase of a positive wobble cycle of the wobble signal. A waveform difference measurement module then measures a difference between the wobble signal and the reference wobble to obtain a series of difference measurement values respectively corresponding to the ADIP bits. A pattern matching module then... |
| Method and apparatus to schedule packets through a crossbar switch with delay guarantees | 20070280261 | 20071206 |
| A method for scheduling cell transmissions through a switch with rate and delay guarantees and with low jitter is proposed. The method applies to a classic input-buffered N×N crossbar switch without speedup. The time axis is divided into frames each containing F time-slots. An N×N traffic rate matrix specifies a quantized guaranteed traffic rate from each input port to each output port. The traffic rate matrix is transformed into a permutation with NF elements which is decomposed into F permutations of N elements using a recursive and fair decomposition method. Each permutation is used to configure the crossbar switch for one time-slot within a frame of size F time-slots, and all F permutations result in a Frame Schedule. In the frame schedule, the expected Inter-Departure Time... |
| Coherent cooperative uwb communication system | 20070280333 | 20071206 |
| This invention relates to a distributed space-time coding method for a UWB pulse telecommunication system wherein a source terminal transmits a signal to a destination terminal during a transmission interval constituted by K frames, K≧1, each frame being divided into a first and a second half-frame, the signal transmitted in each first half-frame being received, then retransmitted after amplification during the next second half-frame by a distinct relay terminal among K relay terminals of said system. The source terminal codes 4K data symbols belonging to a PPM modulation alphabet or a composite PPM-PAM modulation alphabet including a plurality of time positions, to provide a sequence of four transmission symbols per frame, said transmission symbols being obtained from 4K linear combinations of said data symbols using a... |
| Novel virulence determinant within the e2 structural glycoprotein of classical swine fever virus | 20070280955 | 20071206 |
| Classical Swine Fever Virus (CSFV) E2 glycoprotein is a major inducer of neutralizing antibodies and protective immunity in swine. E2 mediates virus adsorption to the target cell, and harbors genetic determinants associated with virus virulence. CSFV E2 also contains between residues 829 and 837 a discrete epitope (TAVSPTTLR) recognized by monoclonal antibody (mAb) WH303, used to differentiate CSFV from related Pestiviruses Bovine Viral Diarrhea Virus (BVDV) and Border Disease Virus (BDV). In this report, a CSFV infectious clone of the virulent Brescia isolate (BICv) was used to progressively mutate the mAb WH303 epitope of CSFV E2 to the homologous amino acid sequence of BVDV strain NADL E2 (TSFNMDTLA). While the resulting virus mutants T1v (TSFSPTTLR), T2v (TSFNPTTLR), T3v (TSFNMTTLR) demonstrated in vitro growth characteristics similar to... |
| Methods and compositions for assaying mutations in nucleic acids and their uses in diagnosis of genetic diseases and cancers | 20070281297 | 20071206 |
| The present invention relates to a method for assaying the presence or the absence of at least one mutation on a strand of nucleic acid paired in a duplex form comprising at least the steps of contacting said duplex with at least one compound able to undergo a specific base pairing interaction with suspected mismatch and assaying for said mismatch by an analytical method. The invention further relates to the use in the diagnosis of predisposition to genetic diseases and cancers and in the diagnosis and prognosis of said diseases and cancers, like human breast cancer. The invention also relates to compositions including a compound able to undergo specific base pairing interaction, in association with a DNA fragment having a nucleic sequence relating to a gene... |
| Adenoviral vectors for treating diseases | 20060292122 | 20061228 |
| Adenoviral vectors, including mutant adenoviruses, that have restriction sites in the E3 region, that facilitate its partial or total deletion, or select genes contained therein, and optionally compositions and methods for substituting heterologous gene(s) in the partially or totally deleted E3 region(s), which heterologous gene(s) being operably linked to endogenous adenoviral transcriptional control sequences will exhibit an expression pattern, both in terms of timing and degree of expression, similar to the endogenous adenoviral gene(s) that it replaces, and further optionally including mutations in other parts of the adenoviral genome, including certain E1B or E1A regions, and that have applications for diagnosing or treating disease, preferably disease involving unwanted cell growth, including cancer.
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| Method for study of the genetic and functional variability of hiv and kit for using it | 20060292553 | 20061228 |
| A method of analyzing a sample possibly containing an HIV virus, including a) extracting viral RNA in a biological sample that possibly contains an HIV virus; b) reverse transcription of the RNA obtained of (a) and amplification with a first pair of primers to obtain an amplified product of reverse transcription including all or part of at least two successive genes of a genome of an HIV virus; and one or both of c) and d): c) sequencing the amplified product of (b) to establish a genotype of HIV virus present in the sample and identify mutations that may be present in the amplified product; d1) amplifying the product of (b) with a second pair of primers complementary to the first pair of (b) and capable... |
| Methods of identifying genomic and proteomic biomarkers for cystic fibrosis, arrays comprising the biomarkers and methods of using the arrays | 20060292562 | 20061228 |
| Cystic fibrosis (CF) is the most common fatal autosomal recessive disease in the U.S. and is principally caused by the DF508 mutation the CFTR gene. The principal site of morbidity and mortality for this disease is the lung. We have used genomic and proteomic methods to identify ubiquitin carboxy terminal hydrolase-1 (UCHL1) as a biomarker for cystic fibrosis. Both gene expression and cognate protein expression are massively upregulated in CF lung epithelial cells. We suggest that this gene can be useful in the assembly of a diagnostic or prognostic chip for CF, or as a target for therapeutic intervention.
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| Nod nucleic acids and polypeptides | 20060292590 | 20061228 |
| The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.
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| Hgf beta chain variants | 20060293235 | 20061228 |
| The invention provides HGF/Met modulators comprising HGF having mutations in regions that affect HGF function, and antagonists that target said regions. The invention further provides methods of identifying, making and using these modulators.
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| Mo54 disruptions, compositions and methods related thereto | 20060294613 | 20061228 |
| The present disclosure relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present disclosure provides transgenic mice comprising mutations in a Mo54 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
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| Recessive plant viral resistance results from mutations in translation initiation factor eif4e | 20060294618 | 20061228 |
| The present invention relates to methods of imparting virus resistance to plants. In one aspect, this method involves silencing a gene encoding a translation initiation factor eIF4E in the plant. In another aspect, this method involves overexpressing a heterologous translation initation factor eIF4E in a plant. The present invention further relates to a genetic construct containing a nucleic acid molecule encoding a heterologous translation initiation factor eIF4E, as well as to an expression system containing the genetic construct and a host cell transformed with the genetic construct. The present invention also relates to transgenic plants, seeds, and plant parts transformed with the genetic construct. The present invention also relates to an isolated nucleic acid molecule encoding a mutant translation initiation factor eIF4E that is effective in... |
| Detecting apparent mutations in nucleic acid sequences | 20060286566 | 20061221 |
| A target nucleic acid sequence information obtained from a biological sample can be compared against a collection of reference nucleic acid sequences. The target nucleic acid sequence is aligned or matched against the reference sequences, wherein some of the target sequences have one or more polymorphisms. Different collections of reference sequences are created and used depending on what one is trying to determine about the target. For example, reference sequences associated with a particular disease may be stored in one or more databases and subsequently compared with a target sequence to determine whether a patient from which the sample sequence was obtained has that disease.
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| Identification of a gene associated with spinocerebellar ataxia type 5 and methods of use | 20060286568 | 20061221 |
| The present invention provides methods that include analyzing an SCA5 polynucleotide, and determining whether the SCA5 polynucleotide includes a mutation. The methods may be used to identify a subject that is at risk or not at risk for developing spinocerebellar ataxia type 5. The present invention also provides isolated polynucleotides having a mutation present in an SCA5 polynucleotide.
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| Mcl-1 quadruplex nucleic acids and uses thereof | 20060286575 | 20061221 |
| A biologically significant quadruplex structure in the MCL-1 regulatory region has been discovered. Certain mutations in quadruplex forming nucleotide sequences alter quadruplex structure and are associated with cancer and perhaps other diseases. Thus, provided herein are MCL-1 quadruplex nucleic acid acids, cancer diagnostics and prognostics, methods for using the cancer diagnostics and prognostics to prevent and/or treat cancer, nucleic acid therapeutics that target altered MCL-1 nucleotide sequences and related methods, methods for identifying compounds that modulate the biological activity of a native MCL-1 quadruplex DNA, and methods for modulating the biological activity of a native MCL-1 quadruplex DNA with a compound identified by the methods described herein. Also provided are methods of selecting a subject for treatment of a cell-proliferative disorder with a quadruplex-interacting molecule.
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| Transforming growth factor alpha hi | 20060286593 | 20061221 |
| The present invention discloses transforming growth factor alpha HI polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
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| Treatment of cns disorders associated with mutations in genes encoding lysosomal enzymes | 20060287358 | 20061221 |
| Described is a method for treating an individual having a neurological disorder with an associated mutation or mutations in a gene encoding a lysosomal enzyme. Specifically, the individual is administered a specific pharmacological chaperone for the lysosomal enzyme which increases trafficking of the protein from the ER to the lysosome in neural cells, with or without concomitantly increasing enzyme activity in neural cells. Restoration of trafficking relieves cell stress and other toxicities associated with accumulation of mutant proteins. Restoration of enzyme activity relieves substrate accumulation and pathologies associated with lipid accumulation. In a specific embodiment, the neurological disorder is Parkinson's disease or parkinsonism which is associated with mutations in glucocerebrosidase.
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| Identification of a jak2 mutation in polycythemia vera | 20060288432 | 20061221 |
| The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group, and to the identification of specific inhibitors and siRNA.
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| Use of mixed duplex oligonucleotides to effect localized genetic changes in plants | 20060288442 | 20061221 |
| The invention concerns the use of duplex oligonucleotides about 25 to 30 base pairs to introduce site specific genetic alterations in plant cells. The oligonucleotides can be delivered by mechanical (biolistic) systems or by electroporation of plant protoplasts. Thereafter plants having the genetic alteration can be generated form the altered cells. In specific embodiments the invention concerns the alteration in the gene that encode acid invertase, UDP-glucose pyrophosphorylase, polyphenol oxidase, O-methyl transferase, cinnamyl alcohol dehydrogenase, ACC synthase and ACC oxidase or etr-1 or homolog of etr-1, and plants having isolated point mutations in such genes.
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| P15 hairpin constructs and use | 20060288445 | 20061221 |
| The present invention concerns a method of genetic modification of a TGB-3 wild type viral sequence for reducing or suppressing the possible deleterious effects of the agronomic properties of a transformed plant or plant cell by said TGB-3 viral sequence, comprising the following successive steps: submitting said sequence to point mutation(s) which allow the substitution of at least one amino-acid into a different amino-acid; selecting genetically modified TGB-3 wild type viral sequences having said point mutation(s) and which are not able to promote cell-to-cell movement of a mutant virus having a dysfunctional TGB-3 wild type viral sequence, when expressed in trans from a replicon; further selecting among said genetically modified TGB-3 viral sequences, the specifically genetically modified sequence which inhibits infection with a co-inoculated wild type... |
| Method for effecting the power-optimal control of bldc motors | 20060279242 | 20061214 |
| A method for a power optimal control of a BLDC motor by continuously updated commutation points and circuit assembly for a power optimal control of a BLDC motor. The method includes measuring a time difference (ΔT) between two immediately subsequent zero crossings (TN1, TN2) of first and second motor phases, and performing a commutation of an immediately next motor phase after substantially one-half of the time difference (ΔT/2) elapses after the zero crossing of the second motor phase (TN2). The commutation is performed for all phases in a continuous manner in accordance with a switching algorithm (Tcommutation=TN2+(ΔT/2)).
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| Frequency change arrangement and radio frequency tuner | 20060281427 | 20061214 |
| A frequency changer arrangement is provided for a radio frequency tuner. The arrangement comprises a first quadrature frequency changer for converting a desired input channel to zero or near-zero intermediate frequency in-phase and quadrature signals. These signals are filtered by low pass filters, whose turnover frequencies may be varied so as to vary the intermediate frequency bandwidth. A second quadrature frequency changer upconverts the filtered signals and supplies these to a summer. The resulting output intermediate frequency is determined by the frequency of commutation signals in the second frequency changer so that the output intermediate frequency may be continuously varied to allow any desired frequency to be selected.
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| Method of efficiently growing modified morning glory plant | 20060282913 | 20061214 |
| The present invention provides a method for efficient tissue culturing of modified morning glory; a method for maintaining and proliferating embryoid bodies throughout the year; and a method for obtaining a large number of modified morning glories from embryoid bodies. The present invention was completed by maintaining and proliferating embryoid bodies by tissue culturing of immature embryo obtained from an individual heterozygous for a mutation as modified morning glory; selecting embryoid bodies capable of exclusively producing modified morning glory; and regenerating plant bodies from the embryoid bodies.
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| Bermuda grass named 'rjt' | 20060282930 | 20061214 |
| A new and distinct cultivar of dwarf Bermuda grass, named RJT, is described and illustrated herein. The cultivar is characterized by its very fine texture when closely mown, the retention of its fine texture at higher heights of cut, its low nutrient needs, its very low thatching characteristics as compared to other dwarf Bermuda grasses, and its prolonged proven stability against mutation.
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| Nucleic acids encoding inactive variants of human telomerase | 20060275267 | 20061207 |
| The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically inactive variants comprising deletions or other mutations are provided.
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| Method for determining predisposition to manifestation of immune system related diseases | 20060275764 | 20061207 |
| The present invention relates to methods for determining predisposition to a manifestation of immune system related diseases, in particular infections, associated with a mutation in the human MASP-2 gene. The invention also features oligonucleotides, polypeptides, peptide fragments and antibodies which are used in the above methods as well as for the manufacture of a medicament for treatment of a disease associated with pathological activity of the lectin-complement pathway. Moreover, the invention provides a series of gene therapy vectors and a kit for diagnosis of the disease associated with a mutation in the human MASP-2 gene.
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| Method of detecting pancreatic islet amyloid protein mutant gene and nucleic acid probe and kit therefor | 20060275772 | 20061207 |
| A melting curve analysis is performed for a nucleic acid containing a mutation in a nucleotide sequence resulting in a mutation replacing serine at position 20 in an amino acid sequence of the pancreatic islet amyloid polypeptide with glycine (IAPP S20G), by using a nucleic acid probe of which end is labeled with a fluorescent dye, and in which fluorescence of the fluorescent dye decreases upon hybridization, wherein the nucleic acid probe has a nucleotide sequence complementary to a nucleotide sequence ending at the nucleotide number 247 in the nucleotide sequence of SEQ ID NO: 1 and having a length of 13 to 30 nucleotides, and the 5′ end of the probe is labeled with the fluorescent dye, and measuring fluorescence of the fluorescent dye, and... |
| Mutations in oas1 genes | 20060275802 | 20061207 |
| Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided.
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| Audio signal separation device and method thereof | 20060277035 | 20061207 |
| Problems of permutation can be solved with high accuracy without utilizing knowledge about original signals or information concerning positions of microphones and the like when each one of plural signals mixed in an audio signal is separated using independent component analysis. A short-time Fourier transformation section generates spectrograms of observation signals from observation signals in time domain. A signal separation section separates the spectrograms of the observation signals into spectrograms of respective signals, to generate spectrograms of separate signals. A permutation problem solution section calculates a scale corresponding to the degree of permutation, e.g., a Kullback-Leiblar information amount calculated by use of a multidimensional probability density function or multidimensional kurtosis, from substantial whole of the spectrograms of the separate signals. Based on the scale, signals at... |
| Technique for determining web services vulnerabilities and compliance | 20060277606 | 20061207 |
| A technique for testing applications for vulnerabilities that may be as a result of loosely defined criteria and restrictions associated with interfacing to the applications. Interfaces associated with an application to be tested are identified. The interfaces may include the names of services provided by the application as well as parameters that are passed to the services. One or more mutant requests containing one or more mutations are then generated based on the identified interfaces. The application is then attacked by forwarding the mutant requests to the application. Vulnerabilities of the application that were exposed as a result of the attack are then detected.
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| Mammal prolactin variants | 20060277614 | 20061207 |
| The invention relates to mammal prolactin (PRL) variants having a mutation or set of mutations within the 14 N-terminal amino acids thereby preventing the formation of a disulfide bridge between Cys4 and Cys11 and, a sterically hindering mutation or set of mutations within binding site 2 of PRL. These variants are useful as antagonists of mammal prolactin receptors (PRLR), more particularly of human prolactin receptor (hPRLR).
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| Electronic communication device with multiple electrodes to electrocute noxious plants | 20060265946 | 20061130 |
| Electronic commutation device with multiple electrodes to electrocute noxious plants”, the present invention refers to an electro mechanic device, generator of electric discharges to eradicate noxious weeds by using an electrode subdivided into smaller electrodes, called multiple electrodes, whereas each multiple electrode is fed by a tension between 1,000 and 35,000 volts, by an electronic commutation system that alternates periods of conduction and cut of electric energy supply for each multiple electrode, lasting between 0.01 and 2.0 seconds; the invention consists of the fact that this system to feed multiple electrodes (7) reduces the number of plants that receive the electric discharge simultaneously and consequently the required power to be supplied by the generator is reduced, significantly improving the yield of the electrocution process; the electric... |
| High speed vacuum porting | 20060266465 | 20061130 |
| This invention proposes a new, improved method and apparatus for applying web segments to a traveling web. These web segments, sometimes called ears or wings, may be asymmetrical or otherwise incompatible with the usual slip-and-cut method. The asymmetrical shape may have differing web tensions which can cause the web segments to be improperly engaged with the vacuum holes on an anvil roll. The present invention utilizes both circumferential rows of vacuum holes and an additional pattern of ear retaining vacuum holes. The circumferential rows of vacuum holes are activated consecutively by vacuum commutation, however, the pattern of ear retaining vacuum holes are activated simultaneously to counter the effects of differing web tensions on the ear portions.
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| Method of operating an electronically commutated motor, and method for carrying out such a method | 20060267531 | 20061130 |
| In this method, the value of a temperature-dependent motor parameter (ke) of an electronically commutated motor (124) is determined during motor operation without a temperature sensor. The motor has a stator (201) having stator phases (202, 204, 206), and a permanent-magnet rotor (208) coacting with that stator, which rotor induces voltages (UIND) in the stator phases during operation, a power stage (122) being associated with the stator phases in order to control their energization. In this method, energization of the stator phases is interrupted while the rotor (208) is rotating. A value (UIND) characterizing an induced voltage, and a value (ω) characterizing a rotation speed of the motor, are ascertained. On the basis of those values, the value of the temperature-dependent motor parameter (ke) is derived.... |
| Method for testing layered data for the existence of at least one value | 20060268107 | 20061130 |
| One or more embodiments of the invention enable a user to search for at least one value in layers of audience specific data comprising language, regional, regulatory and/or cultural specific values per layer. The word “audience” for the purposes of this specification means a group of document consumers such as people or computers that are associated with a language, country, region, regulation or culture. A search utilizing at least one embodiment of the invention occurs with respect to data that makes use of rule-based inheritance. For a three level inheritance embodiment, there are 8 permutations involving a NULL value in at least one of the layers, instead of making the user calculate the proper mask, the Current Audience Layer mask can be logical ORed with the... |
