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Monoclonal

Monoclonal-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Humanized influenza monoclonal antibodies and methods of use thereof
Dana-farber Cancer Institute, Inc.
April 12, 2018 - N°20180099040

The present invention provides structural determinants important for binding to the stem domain of the ha protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular ...
Vaccine compositions and methods of use thereof
University Of Miami
April 12, 2018 - N°20180099032

Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e. G., monoclonal antibody) production, and for the effective delivery of peptides, proteins, sirna, rna or dna to papcs or mhc class ii positive cells (e. G. Tumor cells). Antigens may be, for example, dna that results ...
Composition and methods of genome editing of b-cells
Dana-farber Cancer Institute, Inc.
April 05, 2018 - N°20180094243

The present invention provides methods compositions and methods of preparing autologous b-cells that secrete a monoclonal of interest useful in immunotherapy.
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Monoclonal antibodies to fibroblast growth factor receptor 2
Galaxy Biotech, Llc
April 05, 2018 - N°20180094063

The present invention is directed toward a monoclonal antibody to fibroblast growth factor receptor 2, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient.
Igf-1r antibody and its use for the diagnosis of cancer
Pierre Fabre Medicament
April 05, 2018 - N°20180094060

The present disclosure relates to a novel antibody, in particular a monoclonal antibody, capable of binding to igf-1r, as well as the amino and nucleic acid sequences coding for said antibody.
Lung cancer diagnosis marker, antibody and application thereof
April 05, 2018 - N°20180094042

A human lung cancer marker n3g4, and use of the same as human lung cancer marker is disclosed. Hybridoma cells which produce anti-n3g4 monoclonal antibodies, and the secreted monoclonal antibody lc128, and use of lc128 for the preparation of a diagnostic agent for lung cancer are also disclosed. Kits for in vitro diagnosis comprising the monoclonal antibody lc128 ...
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  • 358+ full patent PDF documents of Monoclonal-related inventions.
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Methods for suppressing allergic reactions
Children's Hospital Medical Center
April 05, 2018 - N°20180092929

A method of treating a subject suffering from an allergic disorder is provided, the method including inducing rapid desensitization to an allergen, the rapid desensitization effectuated by: administering to the subject a plurality of equal doses of a first anti-fcεriα monoclonal antibody, wherein the plurality of equal doses are administered over a 6 to 8 hour period ...
Anti-il-6/il-6r antibodies and methods of use thereof
Novimmune, S.a.
March 29, 2018 - N°20180086839

This invention provides fully human monoclonal antibodies that recognize the il-6/il-6r complex. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
Anti-cd303 monoclonal antibodies
Laboratoire Francais Du Fractionnement Et Des Biotechnologies
March 29, 2018 - N°20180086834

The invention relates to chimeric or humanised anti-cd303 antibodies to nucleic acids coding for the heavy and light chains of these antibodies, expression vectors, host cells, transgenic non-human animals or transgenic plants expressing said antibodies, as well as to the uses thereof in the treatment or prevention of blastic plasmacytoid dendritic cell neoplasms (bpdcn) or inflammatory diseases, in particular autoimmune ...
Mechanically interlocking complexes
Cioty Of Hope
March 29, 2018 - N°20180086826

Provided herein are functionalized monoclonal antibodies (mabs) including antibody fragments, including those where a fab-binding molecule (fab binding moiety) linked to a steric hindering molecule (steric hindering chemical moiety) is mechanically interlocked (e. G., through noncovalent conjugation) with the antibody or antibody fragment. Also provided are compositions that form highly stable and versatile drug delivery and diagnostic compositions.
Human igm antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
March 29, 2018 - N°20180086821

Antibodies, particularly human antibodies, are disclosed having activity in treatment of demyelinating diseases and diseases of the central nervous system. Neuromodulatory agents are provided comprising a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, and active fragments, monomers and combinations thereof having one or more ...
Chromatography media and method
Emd Millipore Corporation
March 29, 2018 - N°20180085743

Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high ...
Whole expressed cell as antigen carrier, and use thereof in preparing vaccine or diagnostic agent, ...
Formosa Biomedical Inc.
March 22, 2018 - N°20180080042

A mammalian cell co-transfect with an expression plasmid comprising t7 promoter and an open reading frame (orf) of target antigen, and a vt7 recombinant vaccinia virus expressing t7 polymerase. The entire antigen expressing cell is used as a carrier of the target antigen for preparing a vaccine or diagnostic agent, and screening monoclonal antibodies.
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  • 358+ full patent PDF documents of Monoclonal-related inventions.
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Carbonic anhydrase ix (g250) antibodies and methods of use thereof
Dana-farber Cancer Institute, Inc.
March 15, 2018 - N°20180072813

The invention provides scfv antibodies and monoclonal antibodies that bind to and decrease an activity of carbonic anhydrase ix (g250). Also provided are the methods of treating and/or preventing cancer, such as renal clear cell cancer. Also provided are methods of identifying a carbonic anhydrase ix (g250) protein. The invention additionally provides methods of modifying immune effector cells, and ...
Anti-cspg4 reagents and methods of treating cancer
The General Hospital Corporation
March 15, 2018 - N°20180072811

Embodiments of the present invention provide antibodies, antigen binding portions thereof, and other polypeptides (e. G., cars), that specifically bind to cspg4, an antigen expressed on cancer cells. Monoclonal antibodies, antibody-drug conjugates, and/or car-t-cells that specifically bind to cspg4 positive cancer cells are also provided.
Oncolytic adenoviruses coding for bi-specific antibodies and methods and uses related thereto
Tilt Biotherapeutics Oy
March 15, 2018 - N°20180072809

The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to cancer therapies of humans. More specifically, the present invention relates to an oncolytic adenoviral vector encoding a bispecific monoclonal antibody. Furthermore, the present invention relates to methods and uses utilizing the oncolytic adenoviral vectors, also together with adoptive cell therapies.
Monoclonal anti-gpc-1 antibodies and uses thereof
Minomic International Ltd.
March 15, 2018 - N°20180072803

The present application is directed to an invention based on the discovery that the blca-38 antibody is actually an antibody population comprising two distinct monoclonal antibodies. The claims define an isolated antibody population comprising first antibodies and/or antigen binding fragments thereof defined by specific heavy chain and light chain variable regions and wherein the antibody population does not contain ...
Stable and soluble antibodies inhibiting vegf
Esbatech, An Alcon Biomedical Research Unit Llc
March 15, 2018 - N°20180072802

The present invention relates to soluble and stable anti-vegf imunobinders comprising cdrs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of vegf-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also ...
Novel anti-netrin-1 antibody
Netris Pharma
March 15, 2018 - N°20180072800

The application discloses a linear or substantially linear epitope on netrin-1 that likely corresponds to the specific binding region of netrin-1 to receptor, in particular of the unc5 class, especially unc5b and unc5a, or alternatively corresponds to a region nearby the specific binding region of netrin-1 to receptor that when bound to an antibody prevents netrin-1/receptor interaction. ...
Methods using antibodies specific for 4,6-diamino-5-(formamido)pyrimidine
Florida State University Research Foundation, Inc.
March 08, 2018 - N°20180066071

The invention includes monoclonal and polyclonal antibodies, and antigen-binding fragments thereof, having specific binding affinity for 4,6-diamino-5-(formylamino)pyrimidine (fapy-adenine); hybridomas producing such antibodies; immunoconjugates comprising an antibody or antigen-binding fragment of the invention coupled to a moiety; and in vitro and in vivo methods for using such antibodies, antibody fragments, and conjugates based on binding to fapy-adenine; nucleic ...
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