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Monoclonal

Monoclonal-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Test object detection method, and immunoassay instrument and monoclonal antibody for same
Denka Seiken Co., Ltd.
June 14, 2018 - N°20180164316

Disclosed is a novel method of detecting a test subject by an immunoassay, in which low sensitivity due to using a monoclonal antibody is improved in spite of using a monoclonal antibody in the immunoassay. The method of detecting a test subject is a method of detecting a test subject having two or more kinds of antigens which enable detection ...
High sensitivity quantitation of peptides by mass spectrometry
Anderson Forschung Group, Llc.
June 14, 2018 - N°20180164301

The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) ...
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
Immunomedics, Inc.
June 14, 2018 - N°20180162945

The present invention concerns compositions and methods of use of anti-hla-dr antibodies or fragments thereof. In preferred embodiments, the antibodies are subcutaneously administered to a human patient with a hematologic cancer or autoimmune disease.
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Antibodies against the rgm a protein and uses thereof
Abbvie Inc.
June 14, 2018 - N°20180162933

The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize rgm a protein. Specifically, these antibodies have the ability to inhibit the binding of rgm a to its receptor and/or coreceptors.
Optimizing diagnostics for galactofuranose containing antigens
The Johns Hopkins University
June 07, 2018 - N°20180156797

Disclosed herein are methods of detecting microbial infection in mammalian subjects comprising treatment of a sample and detection of galactofuranose (galf)-containing antigenic components utilizing monoclonal antibodies. The methods disclosed provide for pretreatment of biological samples, such as urine samples, to maximize detection of galf antigens and improvement of sensitivity of galf antigen detection assays.
Anti-human receptor-type protein tyrosine phosphatase sigma antibody
Sbi Biotech Co., Ltd.
June 07, 2018 - N°20180155446

A monoclonal antibody that binds to an extracellular domain of human receptor-type protein tyrosine phosphatase σ (human ptprs), or a fragment including an antigen-binding region thereof.. .
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  • 358+ full patent PDF documents of Monoclonal-related inventions.
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Antibodies against human and canine il-13ra2
Wake Forest University Health Sciences
June 07, 2018 - N°20180155437

Provided herein are monoclonal antibodies that specifically bind il-13ra2 with cross-reactivity in humans and canines. Also provided are methods of use of the antibodies in the treatment and monitoring of cancers..
Combination therapies with recombinant listeria strains
Advaxis, Inc.
June 07, 2018 - N°20180153974

The disclosure is directed to compositions comprising an oncolytic virus, chimeric antigen receptor t cells (car t cells), a therapeutic or immunomodulating monoclonal antibody, a targeting thymidine kinase inhibitor (tki), or an adoptively transferred cells incorporating engineered t cell receptors, and a live attenuated recombinant listeria strain comprising a fusion protein of a truncated llo, a truncated acta or a ...
Method for quantifying monoclonal antibody
National Cancer Center
May 31, 2018 - N°20180148763

The present invention provides a method for quantifying a monoclonal antibody, the method including: a step of performing selective protease digestion of a monoclonal antibody as a measurement target by bringing a porous body in which the monoclonal antibody is immobilized in pores into contact with fine particles onto which a specific protease is immobilized; and a step of detecting ...
Fungal detection using mannan epitope
Board Of Regents Of The Nevada System Of Higher Eduction, On Behalf Of The University Of Nevada
May 31, 2018 - N°20180148498

Non-invasive methods are provided herein for diagnosing samples as including a fungus, including fungal infection or contamination, with specific monoclonal antibodies capable of detecting molecules associated with fungi in the sample, such as a biological or environmental sample. These molecules can be identified using various methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (...
Therapeutic cd47 antibodies
Tioma Therapeutics, Inc.
May 24, 2018 - N°20180142019

Provided are anti-cd47 monoclonal antibodies (anti-cd47 mabs) with distinct functional profiles as described herein, methods to generate anti-cd47 mabs, and to methods of using these anti-cd47 mabs as therapeutics for the prevention and treatment of solid and hematological cancers, ischemia-reperfusion injury, cardiovascular diseases, autoimmune diseases, inflammatory diseases or as diagnostics for determining the level of cd47 in tissue samples.. .
Anti-cd19 antibodies and methods of use thereof
Novimmune Sa
May 24, 2018 - N°20180142018

The disclosure relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind cd19, as well as methods of making and using these anti-cd19 antibodies and antigen binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.. .
Anti-gdf15 antibodies
Aveo Pharmaceuticals, Inc.
May 24, 2018 - N°20180142013

Monoclonal antibodies that bind and inhibit the activity of human gdf15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human gdf15..
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  • 358+ full patent PDF documents of Monoclonal-related inventions.
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Humanized antibodies
Probiodrug Ag
May 24, 2018 - N°20180140689

The invention relates to humanized antibodies that bind to an epitope at the n-terminus of pyroglutamated amyloid beta (aβ n3pe) peptide and to preventive and therapeutic treatment of diseases and conditions that are related to accumulation and deposition of amyloid peptides, such as amyloidosis, a group of disorders and abnormalities associated with pyroglutamated amyloid peptide, like alzheimer's ...
Pneumococcal serotypes
Instituto Adolfo Lutz
May 17, 2018 - N°20180136224

Disclosed is a new and emerging serotype of streptococcus pneumoniae designated serotype 6c, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}.
Methods of administering inhibitory anti-factor xii/xiia monoclonal antibodies
Csl Ltd
May 17, 2018 - N°20180134806

The invention relates to inhibitory anti-factor xii/fxila antibodies and methods of their use.. .
Monoclonal antigen-binding proteins to intracellular oncogene products
Eureka Therapeutics, Inc.
May 17, 2018 - N°20180134804

Antigen binding proteins specific for an hla-a2 restricted ras peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, fab fragments, f(ab′)2 fragments, and single chain fv fragments.
Human monoclonal antibodies specific for glypican-3 and use thereof
The U.s.a., As Represented By The Secretary, Department Of Health And Human Services
May 17, 2018 - N°20180134800

Described herein is the identification of human monoclonal antibodies that bind gpc3 or heparan sulfate (hs) chains on gpc3 with high affinity. The antibodies described herein are capable of inhibiting hcc cell growth and migration.
Identification of antibodies specific for lyssaviruses and methods of their use
The Government Of The U.s.a. As Rep. By The Secretary Of The Dept.of Health And Human Services
May 17, 2018 - N°20180134767

Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naive antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from ...
Methods for the generation of multispecific and multivalent antibodies
Novimmune S.a.
May 10, 2018 - N°20180127514

The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a kappa constant domain and ...
Antibodies against cd73 and uses thereof
Bristol-myers Squibb Company
May 10, 2018 - N°20180127513

The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human cluster of differentiation 73 (cd73) with high affinity, and inhibit the activity of cd73, and optionally mediate antibody dependent cd73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided.
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