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Monoclonal Antibody

Monoclonal Antibody-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Monoclonal antibody against kir2ds1
National University Corporation Hokkaido University
December 07, 2017 - N°20170350892

A monoclonal antibody to kir2ds1 or a fragment containing an antigen-binding region thereof has vl having an amino acid sequence of seq id no: 1 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as cdr1, having an amino acid sequence of seq ...
Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
Alexion Pharmaceuticals, Inc.
December 07, 2017 - N°20170349652

Eculizumab, a humanized monoclonal antibody against c5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial in a small cohort of patients with paroxysmal nocturnal hemoglobinuria (pnh). The present study examined whether chronic eculizumab therapy could reduce intravascular hemolysis, stabilize hemoglobin levels, reduce transfusion requirements, and improve quality of life in a double-blind, randomized, placebo-controlled, multi-center ...
Novel anti-cd38 antibodies for the treatment of cancer
Sanofi
November 30, 2017 - N°20170343550

Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to cd38, are capable of killing cd3830 cells by apoptosis, antibody-dependent cell-mediated cytotoxicity (adcc), and/or complement-dependent cytotoxicity (cdc). Said antibodies and fragments thereof may be used in the treatment of tumors that express cd38 protein, such as multiple myeloma, chronic ...
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Monoclonal Antibody Patent Applications
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  • 139+ full patent PDF documents of Monoclonal Antibody-related inventions.
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Monoclonal antibody inhibiting immunosuppressive functions of pathogens, antigen-binding fragment thereof, and hybridomas producing such antibody
Sagabio Co., Ltd.
November 30, 2017 - N°20170342137

The present invention relates to a monoclonal antibody that inhibits immunosuppressive functions of pathogens, antigen-binding fragment thereof, and hybridomas producing such antibody. The monoclonal antibody or antigen-binding fragment thereof bind to a peptide consisting an amino acid sequence represented by mekvgkdgvitve (seq id no: 1). The present invention also discloses use of the invented monoclonal antibody or antigen-binding fragment thereof, and ...
Monoclonal antibody against muramyl peptides in prevention and treatment of immune-mediated diseases
Agency For Science, Technology And Research
November 30, 2017 - N°20170342136

Disclosed are methods of treating an autoimmune or inflammatory disease using a composition comprising an isolated antibody or an antigen-binding fragment or variant thereof that is capable of binding to muramyl peptide, derivative, analog or salt thereof, wherein said muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid and a ...
Antibodies with simultaneous subsite specificities to protein and lipid epitopes
Government Of The United States As Represented By The Secretary Of The Army
November 30, 2017 - N°20170342135

Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than one type of antigenic epitope. The antibodies have simultaneous or independent recognition subsites to each of the epitopes. Antigenic epitopes include lipids, peptides, proteins, amino acid sequences, sugars and carbohydrates. Monoclonal antibodies and a method of making monoclonal ...
Monoclonal Antibody Patent Pack
Download 139+ patent application PDFs
Monoclonal Antibody Patent Applications
Download 139+ Monoclonal Antibody-related PDFs
For professional research & prior art discovery
inventor
  • 139+ full patent PDF documents of Monoclonal Antibody-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Anti-human il-17 monoclonal antibodies and use thereof
Chongqing Genrix Biopharmaceutical Co., Ltd.
November 16, 2017 - N°20170327571

The present application discloses a novel anti-human il-17 monoclonal antibody obtained by phage antibody library screening and genetic engineering, or a functional fragment thereof, a polynucleotide encoding the monoclonal antibody or the functional fragment thereof, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or vector, a method for preparing and purifying the antibody, and use of the ...
Humanized monoclonal antibody and uses thereof
Industrial Technology Research Institute
November 09, 2017 - N°20170320966

A humanized monoclonal antibody against the cd34 surface antigen is provided in the present disclosure. The humanized monoclonal antibody includes a light chain variable region and a heavy chain variable region. In which, a nucleotide sequence encoding the amino acid sequence for the light chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of seq id ...
Diagnostic of obliterative arteriopathies
Industrial Technology Research Institute
November 02, 2017 - N°20170315140

The invention relates to a method of diagnosis or prognosis of an obliterative arteriopathy in a subject, comprising determining the expression level of adenosine a2a receptors expressed at the cell surface of peripheral blood mononuclear cells obtained from said subject. The invention also relates to an agonist-like monoclonal antibody directed to the human adenosine a2a receptor, useful for ...
Cervical cancer-related hpv e7 protein monoclonal antibody and use thereof
Industrial Technology Research Institute
November 02, 2017 - N°20170315124

The present invention provides an anti-hpv e7 protein monoclonal antibody and the use thereof. The antibody can detect the hpv16 e7 protein with high specificity and recognize the hpv18 e7 protein, thereby it can distinguish between the cancerous cervical epithelial cells and the cervical abnormal or non-cancerous cervical epithelial cells.
Reagents for detecting or diagnosing cancer cells having high invasive capacity
Industrial Technology Research Institute
November 02, 2017 - N°20170313770

The present invention provides a reagent for detection or diagnosis of cancer, which comprises a monoclonal antibody against mct5 or a fragment thereof.
Method of treating pruritus with il-31 monoclonal antibody formulations
Industrial Technology Research Institute
November 02, 2017 - N°20170313768

The invention provides humanized mouse anti-human il-31 antibodies and antibody fragments that are capable of binding il-31 and thereby neutralizing, inhibiting, limiting, or reducing the proinflammatory or pro-pruritic effects of il-31.
Binding molecules, especially antibodies, binding to l1cam (cd171)
Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts
October 26, 2017 - N°20170306015

The present disclosure relates to a binding molecule binding to l1, which is capable of binding to the same l1 epitope recognized by the monoclonal antibody l1-ov52. 24, and/or which competes with the monoclonal antibody l1-ov52. 24 for binding to l1, wherein the variable part of the light chain of l1-ov52. 24 comprises the sequence according to seq id ...
Monoclonal Antibody Patent Pack
Download 139+ patent application PDFs
Monoclonal Antibody Patent Applications
Download 139+ Monoclonal Antibody-related PDFs
For professional research & prior art discovery
inventor
  • 139+ full patent PDF documents of Monoclonal Antibody-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Multivalent fragments of antibody 3e10 and methods of use thereof
The United States Government As Represented By The Department Of Veterans Affairs
October 12, 2017 - N°20170291961

Antigen binding molecules that bind to the epitope of 3e10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scfv) of monoclonal antibody 3e10, wherein the variant scfv has one or more insertions, deletions, or substitutions relative to a corresponding 3e10 scfv, and wherein the molecule ...
Light-emitting versions of the monoclonal antibody to c3d (mab 3d29) for imaging
The John Hopkins University
October 12, 2017 - N°20170290930

The presently disclosed subject matter provides compositions and kits comprising light-emitting versions of the monoclonal antibody to c3d (mab 3d29) for imaging and methods of use thereof for detecting infectious and inflammatory cells in vivo. The presently disclosed subject matter also provides methods for detecting and/or monitoring a mycobacterium tuberculosis (m. Tuberculosis) infection in a subject, as well ...
Ror1 (ntrkr1) specific chimeric antigen receptors for cancer immunotherapy
Cellectis
October 05, 2017 - N°20170283497

The present invention relates to chimeric antigen receptors (car) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scfv derived from a ror1 monoclonal antibody, conferring specific immunity against ror1 positive cells. The engineered immune cells endowed with such cars are particularly ...
Human anti-il-33 neutralizing monoclonal antibody
Mitsubishi Tanabe Pharma Corporation
October 05, 2017 - N°20170283494

An antibody has an antagonistic effect against il-33. In particular an isolated human anti-il-33 neutralizing monoclonal antibody has framework regions with amino acid sequences from a germline, including combinations and fragments of such sequences. The epitopes for a plurality of anti-il-33 monoclonal antibodies were identified, human anti-il-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ...
Monoclonal antibody and a method thereof
Centro De Inmunologia Molecular
October 05, 2017 - N°20170281808

The present invention relates to a humanized igg1 isotype anti-cd6 antibody (t1h) that binds to the scavenger receptor cysteine-rich (srcr) domain 1 (d1) of cd6 present on the surface of thymic epithelial cells, monocytes, activated t cells and a variety of other cells types.
Monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase
Shionogi & Co., Ltd.
September 28, 2017 - N°20170275378

Provided is a monoclonal antibody or a fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
Trophoblast glycoprotein (5t4, tpbg) specific chimeric antigen receptors for cancer immunotherapy
Cellectis
September 28, 2017 - N°20170275374

The present invention relates to chimeric antigen receptors (car) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scfv derived from a 5t4 monoclonal antibody, conferring specific immunity against 5t4 positive cells. The engineered immune cells endowed with such cars are particularly ...
Egfrviii specific chimeric antigen receptor for cancer immunotherapy
Pfizer Inc.
September 28, 2017 - N°20170275366

The present invention relates to chimeric antigen receptors (car) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scfv derived from an egfrviii monoclonal antibody, conferring specific immunity against egfrviii positive cells. The tcr ko engineered immune cells endowed with such cars ...
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