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Monoclonal Antibody

Monoclonal Antibody-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Multivalent fragments of antibody 3e10 and methods of use thereof
The United States Government As Represented By The Department Of Veterans Affairs
October 12, 2017 - N°20170291961

Antigen binding molecules that bind to the epitope of 3e10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scfv) of monoclonal antibody 3e10, wherein the variant scfv has one or more insertions, deletions, or substitutions relative to a corresponding 3e10 scfv, and wherein the molecule ...
Light-emitting versions of the monoclonal antibody to c3d (mab 3d29) for imaging
The John Hopkins University
October 12, 2017 - N°20170290930

The presently disclosed subject matter provides compositions and kits comprising light-emitting versions of the monoclonal antibody to c3d (mab 3d29) for imaging and methods of use thereof for detecting infectious and inflammatory cells in vivo. The presently disclosed subject matter also provides methods for detecting and/or monitoring a mycobacterium tuberculosis (m. Tuberculosis) infection in a subject, as well ...
Ror1 (ntrkr1) specific chimeric antigen receptors for cancer immunotherapy
Cellectis
October 05, 2017 - N°20170283497

The present invention relates to chimeric antigen receptors (car) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scfv derived from a ror1 monoclonal antibody, conferring specific immunity against ror1 positive cells. The engineered immune cells endowed with such cars are particularly ...
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Monoclonal antibody and a method thereof
Centro De Inmunologia Molecular
October 05, 2017 - N°20170281808

The present invention relates to a humanized igg1 isotype anti-cd6 antibody (t1h) that binds to the scavenger receptor cysteine-rich (srcr) domain 1 (d1) of cd6 present on the surface of thymic epithelial cells, monocytes, activated t cells and a variety of other cells types.
Monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase
Shionogi & Co., Ltd.
September 28, 2017 - N°20170275378

Provided is a monoclonal antibody or a fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
Trophoblast glycoprotein (5t4, tpbg) specific chimeric antigen receptors for cancer immunotherapy
Cellectis
September 28, 2017 - N°20170275374

The present invention relates to chimeric antigen receptors (car) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scfv derived from a 5t4 monoclonal antibody, conferring specific immunity against 5t4 positive cells. The engineered immune cells endowed with such cars are particularly ...
Monoclonal Antibody Patent Pack
Download 139+ patent application PDFs
Monoclonal Antibody Patent Applications
Download 139+ Monoclonal Antibody-related PDFs
For professional research & prior art discovery
inventor
  • 139+ full patent PDF documents of Monoclonal Antibody-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Drug delivery of temozolomide for systemic based treatment of cancer
Cedars-sinai Medical Center
September 28, 2017 - N°20170274085

The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (tmz) by conjugating tmz in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal ...
Protein assay method specific to tracp-5b (tartrate resistant acid phosphatase 5b)
Nitto Boseki Co., Ltd.
September 21, 2017 - N°20170267782

The purpose of the present invention is to provide a monoclonal antibody that is useful in specifically assaying tartrate resistant acid phosphatase 5b (tracp-5b). A hybridoma producing a monoclonal antibody against tracp-5b, said monoclonal antibody showing higher reactivity with tracp-5b than with tartrate resistant acid phosphatase 5a (tracp-5a) and, therefore, being specific to tracp-5b, is ...
Agonistic antibody to cd27
Aduro Biotech Holdings, Europe B.v.
September 21, 2017 - N°20170267771

The invention relates to a binding compound, which binds the same epitope of human cd27 as monoclonal antibody hcd27. 15, produced by hybridoma hcd27. 15 which was deposited with the atcc in on jun. 2, 2010 under number pta-11008. In particular the invention relates to such a binding compound of claim 1 which may comprise: an antibody heavy chain variable region which may comprise at ...
Igf-1r antibody and its use as addressing vehicle for the treatment of cancer
Pierre Fabre Medicament
September 21, 2017 - N°20170267766

The present invention relates to an antibody, in particular a monoclonal antibody, capable of binding to igf-1r, as well as the amino and nucleic acid sequences coding for said antibody. From one aspect, the invention relates to an antibody, or an antigen binding fragment thereof, capable of binding to igf-1r and, by inducing internalization of igf-1r, being ...
Combination therapy for co-administration of monoclonal antibodies
Pierre Fabre Medicament
September 21, 2017 - N°20170267753

Disclosed are methods for enhancing the efficacy of monoclonal antibody therapy, which entails co-administering a therapeutic monoclonal antibody, or a functional fragment thereof, and an effective amount of colchicine or hydroxychloroquine, or a combination thereof, to a patient in need thereof. Also disclosed are methods of prolonging or increasing the time a monoclonal antibody remains in the circulation of a ...
Endotrophin neutralization and use thereof
Board Of Regents Of The University Of Texas System
September 21, 2017 - N°20170267749

Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the c5 ...
Monoclonal antibody based online phosphoprotein proteomics analysis method using microbore hollow fiber enzymatic reactor-tandem mass ...
Korea Research Institute Of Standards And Science
September 14, 2017 - N°20170261513

A phosphoprotein extraction method and a mass spectrometric method using a microbore hollow fiber enzymatic reactor (mhfer) based antigen-antibody reaction and, specifically, to an extraction method and a mass spectrometric method, wherein phosphoproteins or phosphopeptides present in the body are extracted using phosphoserine-, phosphothreonine-, and phosphotyrosine-antibodies, and measured by a mass spectrometer, and thus biomarker phosphoproteins for diagnosis of diseases ...
Monoclonal Antibody Patent Pack
Download 139+ patent application PDFs
Monoclonal Antibody Patent Applications
Download 139+ Monoclonal Antibody-related PDFs
For professional research & prior art discovery
inventor
  • 139+ full patent PDF documents of Monoclonal Antibody-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Monoclonal antibody against human tau protein
Shionogi & Co., Ltd.
September 14, 2017 - N°20170260262

The invention finally describes the use of the immunochemical detection system for diagnosing alzheimer's disease in humans.
Monoclonal antibody against muramyl peptides
Agency For Science, Technology And Research
September 14, 2017 - N°20170260259

Disclosed is an isolated antibody or an antigen-binding fragment thereof the antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing ...
Safety for treating cancers with a glycosylated chimeric antibody to egfr
Sorrento Therapeutics, Inc.
August 31, 2017 - N°20170247458

There is disclosed a chimeric cetuximab-like monoclonal antibody (cmab009 mab) having at least 80% nana glycosylation terminal sialic acid at an n-glycosylation site asn297 and a glycosylation pattern of gal-α(2,3/6)-gal. The disclosed cmab009 monoclonal antibody is a chimeric antibody having the same amino acid sequence (light chain/heavy chain of seq id no. 1/seq id no. 3) as cetuximab (...
Safety and efficacy with a cho cell glycosylated chimeric antibody to tnf
Sorrento Therapeutics, Inc.
August 31, 2017 - N°20170247443

There is disclosed a chimeric infliximab-like monoclonal antibody having at least 80% nana glycosylation terminal sialic acid and a glycosylation pattern of gal-α(2,3/6)-gal that binds to tumor necrosis factor alpha (tnf). The disclosed infliximab-like monoclonal antibody is a chimeric antibody having the same amino acid sequence (light chain/heavy chain of seq id no. 1/seq id no. 2) as ...
Agr2 blocking antibody and use thereof
Shanghai Jiao Tong University
August 24, 2017 - N°20170240651

Disclosed is an agr2 blocking monoclonal antibody, and in particular, a humanized monoclonal antibody for blocking agr2. Also disclosed is a pharmaceutical composition containing the antibody and a method for preparing the same, and a use of the antibody in blocking tumor growth and metastasis.
Anti-pd-1 monoclonal antibody and obtaining method therefor
Beijing Jingyitaixiang Technology Development Co., Ltd.
August 24, 2017 - N°20170240644

The invention provides human monoclonal antibodies that specifically bind to pd-1 with high affinity. The anti-pd-1 monoclonal antibodies were screened from a synthetic antibody library, and affinity maturation was performed. The synthetic antibody libraries used to select for the high affinity anti-pd-1 monoclonal antibodies were made by replacing the light chain cdr1, cdr2 and cdr3 and heavy chain cdr1, cdr 2 ...
Single-chain variable fragment anti-cd133 antibodies and uses thereof
Regents Of The University Of Minnesota
August 24, 2017 - N°20170240627

Disclosed herein are a monoclonal antibody that specifically binds to human cd133 and single-chain variable fragments thereof. Also disclosed herein is a hybridoma that produces the monoclonal antibody that specifically binds to human cd133.
Monoclonal antibodies for treatment of microbial infections
Walter Reed Army Institute Of Research Department Of The Army
August 24, 2017 - N°20170240618

Described are a therapeutic monoclonal antibody specific for the type six secretion system (t6ss) needle protein of acinetobacter baumannii (a. Baumannii) and methods of use. Specifically, the antibody specifically binds to hemolysin co-regulated protein (hep). Further disclosed are methods of using an anti-hep antibody for detecting a. Baumannii in a sample as well as a mutant a. Baumannii strain ...
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