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Methylation

Methylation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Injectable formulations for treating cancer
Epizyme, Inc.
October 12, 2017 - N°20170290765

The present invention provides injectable formulations of (2r,3r,4s,5r)-2-(6-amino-9h-purin-9-yl)-5-((((1r,3s)-3-(2-(5-(tert-butyl)-1h-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which dot 1-mediated protein methylation plays a part, such as cancer and neurological disorders.
Methods for reproducing plants asexually and compositions thereof
Centro De Investigacion Y De Estudios Avanzados Del Instituto Politecnico Nacional (cinvestav)
October 12, 2017 - N°20170290279

Disclosed are methods of obtaining clonal seeds, methods of plant cloning, methods of screening for maternal plants that produce clonal seeds asexually and methods of increasing yield of clonal seeds. Also disclosed are constructs comprising a nucleic acid that may silence the activity of a rna-dependent dna methylation pathway gene. Further disclosed are maternal plants comprising a construct wherein the ...
Early lung cancer detection by dna methylation phenotyping of sputum-derived cells
The Regents Of The University Of California
October 05, 2017 - N°20170283881

In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in 5 the process of lung cancer development. The method includes the staining of extracted cells with fluorescent reporters that produce a specific pattern ...
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Biomarker foxf2 for gastric cancer
The Chinese University Of Hong Kong
October 05, 2017 - N°20170283875

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the foxf2 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides ...
Method of analysis allowing avoidance of surgery
Miodx
September 28, 2017 - N°20170275702

A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) dna methylation of tumor suppressor genes; (c) non-coding rna expression (microrna profiling); and (d) long non-coding rna expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, ...
Methods for detecting genomic dna methylation
The Trustees Of The University Of Pennsylvania
September 28, 2017 - N°20170275686

The presently disclosed subject matter provides high-throughput methods for performing genomic dna methylation assessments. The presently disclosed subject matter further provides methods for diagnosing a subject with a disease and/or disorder, and for determining the prognosis of a subject that has a disease and/or disorder. In certain embodiments, the present disclosure provides a diagnostic method that includes obtaining ...
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Methylation Patent Applications
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  • 124+ full patent PDF documents of Methylation-related inventions.
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  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Biomarker scnn1b for gastric cancer
The Chinese University Of Hong Kong
September 21, 2017 - N°20170268062

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the scnn1b gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention ...
Dna hypermethylation of promoters of target genes and clinical diagnosis and treatment of hpv related ...
The Johns Hopkins University
September 21, 2017 - N°20170268059

The present invention provides arrays for gene loci that allow diagnosis of cervical cancer in patients who may be asymptomatic or have inconclusive pap smears or cytology, and allowing earlier diagnosis and treatment of the subject. The present invention also provides methods of determination of a global promoter dna methylation in a cervical tissue sample from a subject, using a ...
Compounds, compositions and methods for making the same
Signum Biosciences, Inc.
September 21, 2017 - N°20170266161

The present invention provides compounds and/or compositions that modulate pp2a methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of pp2a, modulating the methylation of pp2a and/or modulating the activity of pp2a.
Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem ...
Delmar Pharmaceuticals, Inc.
September 21, 2017 - N°20170266150

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on dna that creates n7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the mgmt repair mechanism.
Preservation of information related to genomic dna methylation
Illumina, Inc.
September 14, 2017 - N°20170260581

The present invention relates to compositions, methods and systems for analyzing the methylation state of nucleic acids. Some embodiments relate to a compositions, methods and systems for analyzing the methylation state of dna with a gene array.
Heritable epigenetic modifications as markers of chemotherapy exposure
Seattle Children's Hospital Dba Seattle Children's Research Institute
September 07, 2017 - N°20170253927

Provided herein are epigenetic modifications that are associated with prior exposure to chemotherapy agents. In particular, differential dna methylation regions (dmrs) that are characteristic of, and can thus be used to identify and/or treat, a male subject who has undergone chemotherapy are provided. The dmrs are used to screen for pregnancy complications, infertility, and passage of heritable mutations to ...
Biomarkers for head and neck cancer and methods of their use
The Regents Of The University Of Colorado, A Body Corporate
August 31, 2017 - N°20170247767

Disclosed is a diagnostic panel of methylated genomic loci encoding microrna (mgmir) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell carcinoma (hnscc). These results represent the first use of quantitative ms-pcr for the detection of mgmirs. In addition this panel demonstrates the ability to detect hypermethylation in the adjacent mucosa of cancer patients, ...
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Download 124+ patent application PDFs
Methylation Patent Applications
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inventor
  • 124+ full patent PDF documents of Methylation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Novel imines with tunable nucleophilicity and steric properties through metal coordination: applications as ligands and ...
King Abdullah University Of Science And Technology
August 31, 2017 - N°20170246621

The invention describes phospho-amino pincer-type ligands, metal complexes thereof, and catalytic methods comprising such metal complexes for conversion of carbon dioxide to methanol, conversion of aldehydes into alcohols, conversion of aldehydes in the presence of a trifluoromethylation agent into trifluorinated secondary alcohols, cycloaddition of carbon dioxide to an epoxide to provide cyclic carbonates or preparation of an amide from the ...
Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
Genomictree, Inc.
August 24, 2017 - N°20170240977

The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed ...
Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
Genomictree, Inc.
August 24, 2017 - N°20170240976

The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed ...
Biomarkers for cervical cancer
Academisch Ziekenhuis Groningen
August 24, 2017 - N°20170240974

The invention relates to methods, reagents and kits for detecting the susceptibility to cervical cancer. In particular, it relates to novel methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3 (cin2/3) and the use thereof for identifying a cervical cell as neoplastic or predisposed to neoplasia in an isolated sample.
Method of multivariate molecule analysis
Miodx
August 17, 2017 - N°20170233825

A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) dna methylation of tumor suppressor genes; (c) non-coding rna expression (microrna profiling); and (d) long non-coding rna expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, ...
Methods for detecting cpg methylation and for diagnosing cancer
Epigenomics Ag
August 17, 2017 - N°20170233820

The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated dna. The detection of cpg methylation in marker dna is useful for the diagnosis of cancers and the invention provides improved methods for this purpose. These improved methods allow in particular for a more sensitive detection of methylated marker dna ...
Epigenetic markers for the identification of blood sub-cells of type 1
Epiontis Gmbh
August 17, 2017 - N°20170233807

The present invention relates to a method, in particular an in vitro method, for identifying cd3cd4 positive t lymphocytes of a mammal, wherein said method comprises analysing the methylation status of at least one cpg position in the cd3a/b/c/d/g genes, in particular their “upstream” regulatory regions, and in particular the ...
Dna methylation markers for overgrowth syndromes
The Hospital For Sick Children
August 10, 2017 - N°20170226570

The present disclosure provides epigenetic signatures, comprising genomic cpg dinucleotide sequences, genes, and/or genomic regions, which are differentially methylated in individuals with sotos syndrome relative to non-sotos syndrome controls, and their use in methods and kits for detecting and/or screening for sotos syndrome, or the likelihood of sotos syndrome. The present disclosure also provides epigenetic signatures, comprising genomic ...
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