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Methylation

Methylation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Methods of preparing dual-indexed dna libraries for bisulfite conversion sequencing
Grail, Inc.
February 15, 2018 - N°20180044731

Described herein are methods of preparing dual-indexed nucleic acid libraries for methylation profiling using bisulfite conversion sequencing. In various embodiments, the methods use a two-step indexing process to tag bisulfite-treated dna with unique molecular identifiers (umis).
NEW Selective oxidation of 5-methylcytosine by tet-family proteins
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servic
February 15, 2018 - N°20180044633

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine ...
NEW Selective oxidation of 5-methylcytosine by tet-family proteins
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servic
February 15, 2018 - N°20180044632

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine ...
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Anti-tumor vaccine derived from normal cells
Cytovac A/s
February 08, 2018 - N°20180036397

A composition for inducing an immune response in a mammal, comprises lymphoid cells in which expression of tumor antigens has been chemically induced. The tumor antigens are induced in proliferating normal lymphoid cells, especially during the log phase of proliferation. The proliferation of the normal lymphoid cells is stimulated by normal mature dendritic cells. Most conveniently, the lymphoid cells are ...
Ulcerative colitis (uc)-associated colorectal neoplasia markers
Baylor Research Institute
February 01, 2018 - N°20180030545

Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of mir-1, -9, -124, mir-137 and/or mir-34b/c in samples from uc patients.
Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of ...
Rubicon Genomics, Inc.
February 01, 2018 - N°20180030527

The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as dna methylation patterns, through the preparation, amplification and analysis of methylome libraries. In particular, the method employs preparation of a dna molecule by digesting the dna molecule with at least one methylation-sensitive restriction enzyme; incorporating a nucleic acid molecule into at least some of ...
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Methylation Patent Applications
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  • 124+ full patent PDF documents of Methylation-related inventions.
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Systems and methods for epigenetic sequencing
The General Hospital Corporation
January 25, 2018 - N°20180023133

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the dna (e. G., from nucleosomes) within the droplets are labeled, e. G., with adapters containing an identification sequence. The adapters may also contain other sequences, e. G., restriction sites, primer sites, etc., ...
Method for detecting methylation of colorectal cancer specific methylation marker gene for colorectal cancer diagnosis
Genomictree, Inc.
January 18, 2018 - N°20180016644

The present disclosure relates to a method for detecting methylation of the bowel-cancer-specific methylation marker gpm6a (nm_201591, glycoprotein m6a) gene in order to diagnose bowel cancer, and more specifically relates to a method for providing information for diagnosing bowel cancer by detecting the methylation of a bowel-cancer-specific marker gene that is specifically methylated in bowel cancer cells. The ...
Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
Genomictree, Inc.
January 18, 2018 - N°20180016643

The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed ...
Gene composition for detecting cell proliferative abnormality or grading disease degree and use thereof
Biochain (beijing) Science & Technology, Inc.
January 18, 2018 - N°20180016639

The present invention provides a composition, a kit and the use thereof, as well as the method for detecting the cell proliferative abnormality in individuals or grading the disease degree in the individuals. The composition comprises nucleic acids for detecting the methylation level within at least one target region of a gene and the fragment thereof.
Novel fatty acid modified urocortin-2 analogs for the treatment of diabetes and chronic kidney disease
January 18, 2018 - N°20180016318

Wherein the x1 denotes that the i residue is modified by either acetylation or methylation at the n-terminus; wherein x2 is l or t; wherein x3 is l or i; wherein x4 is q or e; and wherein a modified k residue (“k*”) at position 29 is modified through conjugation to the epsilon-amino group of the k-side ...
Treatment of aromatic alkylation feedstock
Exxonmobil Chemical Patents Inc.
January 18, 2018 - N°20180016207

In a process and system for treatment of feed stocks comprising alkylating agent and metal salts, the metal salts are removed from the feedstock by an efficient combination of separations processes. The processes may take place in one or more stages, each stage taking place in one or more vessels. Such treatment processes may remove 99. 9% or more of metal salts ...
Leukemia methylation markers and uses thereof
The Regents Of The University Of California
January 11, 2018 - N°20180010192

Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
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Methylation Patent Applications
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  • 124+ full patent PDF documents of Methylation-related inventions.
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Fatty amino alcohols and process for preparing same
Universite D'artois
January 04, 2018 - N°20180002274

The present invention relates to amino alcohol compounds and to the preparation thereof from fatty esters comprising at least two carbon-carbon double bonds. In particular, the present invention relates to fatty amino alcohol compounds obtained by means of a process coupling, in a single step, a hydroaminomethylation reaction and a hydrohydroxymethylation reaction.
Kit and method for detecting mutations in ctnnb1 and htert, and use thereof in hcc ...
Jbs Science Inc.
December 28, 2017 - N°20170369947

Provided herein are a kit and method for detecting mutations in ctnnb1 and htert, and their use in detection and management of hepatocellular carcinoma (hcc). The kit comprises a first pair of primers, configured to specifically bind sequences flanking the genomic region for amplifying the genomic region in a first pcr reaction; and at least one clamp, each configured to ...
Systems and methods for genome modification and regulation
The Johns Hopkins University
December 28, 2017 - N°20170369855

The present invention provides methods of systems and methods of site specific methylation.
Age-modified cells and methods for making age-modified cells
Memorial Sloan-kettering Cancer Center
December 21, 2017 - N°20170363618

Provided are age-modified cells and method for making age modified cells by reducing or increasing the level of genomic nucleic acid methylation in the cells. The aging and/or maturation process can be accelerated or reduced and controlled for young, aged, mature and/or immature cells, such as a somatic cell, a stem cell, a stem cell-derived somatic cell, including ...
Use of methylation sites in y chromosome as prostate cancer diagnosis marker
Beijing Institute Of Genomics, Chinese Academy Of Sciences
December 21, 2017 - N°20170362663

Disclosed is a use of methylation sites as a disease diagnosis marker, in particular relating to a use of methylation sites in a y chromosome as a prostate cancer diagnosis marker. More particularly, the method and criterion for screening methylation sites in chromosomes associated with a disease are established in the present invention, and using prostate cancer as an example, ...
Toluene methylation with transalkylation of heavy aromatics
Saudi Basic Industries Corporation
December 21, 2017 - N°20170362142

A method of producing a purified mixed xylene comprising: introducing toluene and methanol to an alkylation reactor; reacting the toluene and the methanol in the alkylation reactor to form a hydrocarbon stream comprising a first mixed xylene, wherein the alkylation reactor comprises an alkylation catalyst; separating the hydrocarbon stream into a toluene stream and a separated c8+ stream; introducing the ...
Method for estimating sensitivity to drug therapy for colorectal cancer
The University Of Tokyo
December 14, 2017 - N°20170356051

The present invention relates to a method for predicting responsiveness to cancer drug therapy for colorectal cancer. More particularly, the present invention relates to a method for predicting the responsiveness of a colorectal cancer patient to cancer drug therapy, the method comprising analyzing the level of dna methylation in a specimen comprising a colorectal cancer tissue, colorectal cancer cells, or ...
A dna-methylation test for prostate cancer
University College Dublin National University Of Ireland, Dublin
December 07, 2017 - N°20170349952

A method of determining the risk of metastatic prostate cancer in an individual diagnosed with prostate cancer, the method comprising a step of assaying a biological sample obtained from the individual for the presence of at last one methylated regulatory dna sequence selected from group comprising: sequence id no's 1 to 16, or variants thereof, and correlating the presence or absence of ...
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