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Methylation

Methylation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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A dna-methylation test for prostate cancer
University College Dublin National University Of Ireland, Dublin
December 07, 2017 - N°20170349952

A method of determining the risk of metastatic prostate cancer in an individual diagnosed with prostate cancer, the method comprising a step of assaying a biological sample obtained from the individual for the presence of at last one methylated regulatory dna sequence selected from group comprising: sequence id no's 1 to 16, or variants thereof, and correlating the presence or absence of ...
Detecting hematological disorders using cell-free dna in blood
The Chinese University Of Hong Kong
December 07, 2017 - N°20170349948

Techniques are provided for detecting hematological disorders using cell-free dna in a blood sample, e. G., using plasma or serum. For example, an assay can target one or more differentially-methylated regions specific to a particular hematological cell lineage (e. G., erythroblasts). A methylation level can be quantified from the assay to determine an amount of methylated or unmethylated dna fragments ...
Production of differentiated enteroendocrine cells and insulin producing cells
The Brigham And Women's Hospital, Inc.
December 07, 2017 - N°20170349884

A population of enteroendocrine cells (eec) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate chga and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of chga is such that the fraction of cells expressing cga in ...
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Method for detecting methylation of colorectal cancer specific methylation marker gene for colorectal cancer diagnosis
Genomictree, Inc.
November 23, 2017 - N°20170335407

The present disclosure relates to a method for detecting methylation of the bowel-cancer-specific methylation marker gpm6a (nm_201591, glycoprotein m6a) gene in order to diagnose bowel cancer, and more specifically relates to a method for providing information for diagnosing bowel cancer by detecting the methylation of a bowel-cancer-specific marker gene that is specifically methylated in bowel cancer cells. The ...
Method for detecting the methylation of colorectal-cancer-specific methylation marker genes for colorectal cancer diagnosis
Genomictree, Inc.
November 23, 2017 - N°20170335405

The present disclosure relates to a method for detecting cpg methylation of sdc2 (syndecan 2) gene, a kit for detecting cpg methylation of sdc2 (syndecan 2) gene, and a method for detecting cpg methylation of sdc2 (syndecan 2) gene for a colorectal cancer diagnosis.
Method for fragmenting a nucleic acid for sequencing
Population Genetics Technologies Ltd.
November 23, 2017 - N°20170335371

Providing herein, among other things, is a method for preparing a nucleic acid for sequencing. In some embodiments, the method comprises a) amplifying a nucleic acid template using a dntp mix that contains 5-methyl dctp, thereby producing product nucleic acid molecules that contains methylcytosines; b) digesting the product nucleic acid molecules with a methylation-dependent restriction endonuclease, thereby cleaving the product ...
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Methylation Patent Applications
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  • 124+ full patent PDF documents of Methylation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3...
Children's Medical Center Corporation
November 16, 2017 - N°20170327846

The present invention provides methods and compostions to improve the efficiency of somatic cell nuclear transfer (scnt) and the consequent production of nuclear transfer esc (ntesc) and transgenic cells and/or non-human animals. More specifically, the present invention relates to the discovery that trimethylation of histone h3-lysine 9 (h3k9me3) in reprogramming resistant regions (rrrs) in the nuclear genetic ...
Prediction marker
Tohoku University
November 09, 2017 - N°20170322221

An object of the present invention is to provide a prediction marker in male animals for predicting behaviors of their offspring. Specifically, isolated h3k79me3 from a spermatocyte or a sperm of a male animal is used as a marker. When levels of methylation of h3k79me3 in a spermatocyte or a sperm which has been collected from ...
Nlrc5 as a biomarker for cancer patients and a target for cancer therapy
The Texas A&m University System
November 09, 2017 - N°20170321285

The invention pertains to biomarkers for identifying a cancer that is likely or not likely to evade the immune system of a subject, thus, is likely or not likely to show better prognosis (prognostic biomarker) and/or better responses to cancer therapies (predictive biomarker). The invention provides a method of identifying a subject as having a cancer that is likely ...
Epigenetic markers of pluripotency
Zymo Research Corporation
November 09, 2017 - N°20170321274

Epigenetic methods for assessing pluripotentcy of a cell population, such as a stem cell culture are provided. For example, pluripotency can be assessed by determining dna methylation status at the rab25, nanog, ptpn6, mgmt, gbp3 and/or lyst gene regions. Kits and reagents for testing cells are likewise provided.
Cancer marker and cancer determination method
Wako Pure Chemical Industries, Ltd.
November 09, 2017 - N°20170321247

The invention relates to a cancer marker, consisting of a portion of or all of the nucleotide sequence represented by seq id no: 1 in a foxb2 gene derived from a cell, and being continuous nucleotide sequences comprising at least the nucleotide sequence represented by seq id no: 2 or 3, wherein 30% or more of cytosines of the -cg- sequences present in said ...
Detection of dna that originates from a specific cell-type and related methods
Wako Pure Chemical Industries, Ltd.
November 02, 2017 - N°20170314073

The present invention relates to methods to detect an amount of dna that originates from cells of a given type, where the sample comprising such dna in admixture with dna that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the dna that originates from the given type of cells compared to ...
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful ...
Wako Pure Chemical Industries, Ltd.
November 02, 2017 - N°20170314071

Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
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Methylation Patent Applications
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  • 124+ full patent PDF documents of Methylation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Compositions and methods for detecting predisposition to a substance use disorder
Behavioral Diagnostics, Llc
October 26, 2017 - N°20170306408

The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder.
Dna methylation markers for neurodevelopmental syndromes
The Hospital For Sick Children
October 26, 2017 - N°20170306406

The present disclosure provides epigenetic signatures, comprising genomic cpg dinucleotide sequences, genes, and/or genomic regions, which are differentially methylated in individuals with charge syndrome relative to non-charge syndrome controls, and their use in methods and kits for detecting and/or screening for charge syndrome, or the likelihood of charge syndrome. The present disclosure also provides epigenetic signatures, comprising genomic ...
Dna methylation status as a biomarker of alcohol use and abstinence
The Hospital For Sick Children
October 26, 2017 - N°20170306405

This disclosure provides methods and materials for determining whether or not an individual is using alcohol, and also for determining whether or not the individual has stopped using alcohol.
Multiplex methylation-specific amplification systems and methods
Abbott Molecular Inc.
October 26, 2017 - N°20170306395

The present invention relates to systems and methods for performing multiplex amplification reactions. In particular, the present invention relates to multiplex methylation-specific amplification systems and methods.
Nucleic acids and methods for detecting methylation status
Abbott Molecular Inc.
October 19, 2017 - N°20170298427

The invention provides compositions and methods for determining whether a subject is predisposed to the disease or condition, or for diagnosing a disease or condition, or for detecting the state of a disease or condition, by detecting the methylation state of the subject's nucleic acids. In addition, the invention provides methods for determining the methylation age of a subject or ...
Simultaneous single-molecule epigenetic imaging of dna methylation and hydroxymethylation
Abbott Molecular Inc.
October 19, 2017 - N°20170298422

Provided herein is a method for analyzing genomic dna. In some embodiments, the method may comprise labeling a genomic sample by adding a capture tag to the ends of the dna molecules in the sample and labeling molecules that comprise hydroxymethylcytosine with a first fluorophore, immobilizing the labeled dna molecules on a support, and imaging individual molecules of hydroxymethylated genomic ...
Injectable formulations for treating cancer
Epizyme, Inc.
October 12, 2017 - N°20170290765

The present invention provides injectable formulations of (2r,3r,4s,5r)-2-(6-amino-9h-purin-9-yl)-5-((((1r,3s)-3-(2-(5-(tert-butyl)-1h-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which dot 1-mediated protein methylation plays a part, such as cancer and neurological disorders.
Methods for reproducing plants asexually and compositions thereof
Centro De Investigacion Y De Estudios Avanzados Del Instituto Politecnico Nacional (cinvestav)
October 12, 2017 - N°20170290279

Disclosed are methods of obtaining clonal seeds, methods of plant cloning, methods of screening for maternal plants that produce clonal seeds asexually and methods of increasing yield of clonal seeds. Also disclosed are constructs comprising a nucleic acid that may silence the activity of a rna-dependent dna methylation pathway gene. Further disclosed are maternal plants comprising a construct wherein the ...
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