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Methylation

Methylation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Immunoassays of s-adenosylmethionine and methylation index in personalized medicine and health evaluation
June 07, 2018 - N°20180156816

The invention provides a method of detecting the presence, absence or severity of a disease in a patient wherein said disease is accompanied by decreased level of s-adenosylmethionine, or increased level of s-adenosylhomocysterine, or reduced methylation index comprising: identifying any individual or a patient that is suspected of having said disease or is at risk of having said disease; obtaining ...
Marker for prenatal diagnosis and monitoring
The Chinese University Of Hong Kong
June 07, 2018 - N°20180155791

The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal dna present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal dna and in maternal dna and provides these new diagnostic methods, which distinguish fetal dna from maternal dna and detect prenatal disorders ...
Systems and methods for epigenetic sequencing
The General Hospital Corporation
June 07, 2018 - N°20180155778

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the dna (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence.
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Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials
North Carolina State University
June 07, 2018 - N°20180155729

The invention relates to the methods for modifying the methylation pattern of bacteriophage dna and phagemid dna and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage dna or phagemid dna comprising components of an engineered crispr-cas system.. .
Process of producing paraxylene by the methylation of toluene and/or benzene
Exxonmobil Chemical Patents Inc.
June 07, 2018 - N°20180155255

A process for producing paraxylene by the catalytic alkylation of benzene and/or toluene with methanol. In prior art processes, water is typically co-injected with the methanol to improve the utilization of methanol, increase the amount of methanol that reacts with the benzene and/or toluene, and decrease the amount of methanol that decomposes to undesirable carbon monoxide, carbon dioxide, ...
Analysis of cell-free dna in urine and other samples
The Chinese University Of Hong Kong
May 31, 2018 - N°20180149636

Diseases (e.g., cancer) of a particular organ can be detected by analyzing cell-free dna. Some embodiments may use an organ-associated sample that is from a particular organ or passes through the particular organ, as may occur, for example, in urine, saliva, blood, and stool samples.
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Methylation Patent Applications
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inventor
  • 124+ full patent PDF documents of Methylation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Method of epigenetic analysis for determining clinical genetic risk
The Johns Hopkins University
May 31, 2018 - N°20180148783

The present invention provides a method for identifying a subject having or at risk of having a metabolic disease, such as diabetes or obesity. The invention is based on an approach to identify candidate genes involved in metabolic diseases, such as obesity and type 2 diabetes (t2d) through epigenetic mechanisms.
Assays to determine dna methylation and dna methylation markers of cancer
Zymo Research Corporation
May 31, 2018 - N°20180148776

Methods are provided for determining a genomic methylation profile in a dna sample. In certain aspects, the methods can be used to determine if a subject has, or is at risk for developing, a bladder cancer or other cancers of the urinary tract.
Process for the synthesis of 9,9-bis(methoxymethyl)fluorene
Sabic Global Technologies B.v.
May 31, 2018 - N°20180148397

The present invention relates to a novel process for the synthesis of 9,9-bis(methoxymethyl)fluorene. The syntheses from fluorene to 9,9-bis(hydroxymethyl)fluorene via a hydroxymethylation and further to 9,9-bis(methoxymethyl)fluorene via a etherification are known.
Method for detecting differentially methylated cpg islands associated with abnormal state of human body
Beijing Shijitan Hospital, Capital Medical University
May 24, 2018 - N°20180143198

Disclosed is a method for detecting differentially methylated cpg islands associated with an abnormal state of a human body, characterized by detecting very minute amounts of methylated cpg short tandem nucleic acid sequences in highly fragmented dna samples with genome scale, identifying differentially methylated cpg islands associated with abnormal state of human body and determining the corresponding abnormal state of ...
Systems and methods to predict autism before onset of behavioral symptoms and/or to diagnose ...
Bioscreening & Diagnostics Llc
May 24, 2018 - N°20180142298

Systems and methods to predict or diagnose autism are described. Using markers, the systems and methods can predict or diagnose autism based on significant differences in methylation of cytosine bases in many loci throughout the genome.
Use of dianhydrogalactitol and analogs or derivatives thereof in combination with platinum-containing antineoplastic agents to ...
Delmar Pharmaceuticals, Inc.
May 24, 2018 - N°20180140571

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (nsclc) and ovarian cancer, as well as other types of malignancy, including brain metastases of nsclc. Dianhydrogalactitol acts as an alkylating agent on dna that creates n7 methylation.
Unbiased dna methylation markers define an extensive field defect in histologically normal prostate tissues associated ...
Wisconsin Alumni Research Foundation
May 17, 2018 - N°20180135136

A method of detecting the presence of a prostate cancer field defect in a human subject comprising the step of (a) obtaining genomic dna from the human subject and (b) quantitating methylation in at least one target region selected from the group consisting of pla2g16, cav1, evx1, mcf2l, fgf1, ncr2 and wnt2 and ext1 and spag4 target, wherein ...
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Methylation Patent Applications
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For professional research & prior art discovery
inventor
  • 124+ full patent PDF documents of Methylation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Detection of dna methylation
Zymo Research Corporation
May 17, 2018 - N°20180135113

In a first aspect, the invention concerns a method for detecting or quantifying dna methylation at a locus. In one embodiment, a methylation-sensitive endonuclease is formulated together with a polymerase enzyme in an appropriate reaction mixture such that amplification of dna occurs in a methylation specific manor.
Methods of synthesizing substituted purine compounds
Epizyme, Inc.
May 17, 2018 - N°20180134745

The present invention provides an efficient process for the synthesis of (2r,3r,4s,5r)-2-(6-amino-9h-purin-9-yl)-5-((((1r,3s)-3-(2-(5-(tert-butyl)-1h-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which dot1-mediated protein methylation plays a part, such as ...
Methods of synthesizing substituted purine compounds
Epizyme, Inc.
May 17, 2018 - N°20180134744

The present invention provides an efficient process for the synthesis of (2r,3r,4s,5r)-2-(6-amino-9h-purin-9-yl)-5-((((1r,3s)-3-(2-(5-(tert-butyl)-1h-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which dot1-mediated protein methylation plays a part, such as ...
Substituted purine compounds
Epizyme, Inc.
May 10, 2018 - N°20180127451

The present invention relates to substituted purine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which dot1-mediated protein methylation plays a part, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof..
Process for preparing polyols
Universite D'artois
May 10, 2018 - N°20180127350

The present invention relates to a process for preparing polyols. In particular, the present invention relates to the preparation, in a single step, of polyols by a process involving a hydrohydroxymethylation reaction starting from a composition a comprising one or more compounds of formula (i)..
Compositions and methods to accelerate resolution of acute lung inflammation
The Johns Hopkins University
May 10, 2018 - N°20180125874

The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an il-4 polypeptide or fragment thereof possessing cytokine activity or an il-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury.
Dark tobacco inbreds and hybrids comprising reduced nicotine demethylation and nornicotine
Altria Client Services Llc
May 10, 2018 - N°20180125026

The present disclosure provides tobacco inbred plants tnd950 (phph) src, narrow leaf madole (phph) src, narrow leaf madole src, cms tnd950 src, cms narrow leaf madole src, and cms ky171 src, and hybrids pd7305 src, pd7309 src, pd7312 src, pd7318 src, and pd7319 src. The present disclosure also provides parts of such plants and products made from those parts.
Chemical refinery performance optimization
Uop Llc
May 03, 2018 - N°20180122021

Processes and apparatuses for toluene methylation in an aromatics complex for producing paraxylene. More specifically, the present disclosure relates to processes and apparatuses wherein a toluene methylation zone is integrated within an aromatics complex for producing paraxylene thus allowing no benzene byproduct to be produced.
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