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Metered Dose Inhaler patents

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 Delivery system for metered dose inhalers patent thumbnailDelivery system for metered dose inhalers
A device for delivering medications with hydroflouroalkane propellant driven metered-dose inhalers (mdis). The device includes a collapsible bag to which is attached a bidirectional mouthpiece and an adaptor that receives the mdi.

 Metered dose inhaler and methods thereof patent thumbnailMetered dose inhaler and methods thereof
A process and a metered dose inhaler, comprising: an air actuator comprising at least one inlet of liquefied gas (lg), at least one air outlet, at least one first lg-expanding volume and at least one second air-containing volume, the first and second volumes are effectively separated by means of a lg-blocking member; a container with an lg source; said container is in a fluid connection with said lg-expanding volume via the at least one lg inlet; the air actuator is facilitating a metered dose airflow by allowing the expansion of said lg in said at least one lg-expanding volume from its condensed liquid phase to its expanded gas phase. The expansion of said lg facilitates the compression of the air within said at least one air-containing volume, such that a metered dose lg-free air flow is inhalable via at least one air outlet..
Meway Pharma Ltd


 Drug delivery device patent thumbnailDrug delivery device
Drug delivery devices are described that include sensors and processing circuitry that can detect operating events, such as flow rates and drug delivery, in various types of inhalers, such as dry powder inhalers, metered dose inhalers, nasal inhalers and nebulisers. The information determined by the processing circuitry can be used to provide feedback to the user or can be stored or transmitted for subsequent analysis.
Sagentia Limited


 Aerosol medication inhalation system patent thumbnailAerosol medication inhalation system
An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject..

 Pharmaceutical metered dose inhaler and methods relating thereto patent thumbnailPharmaceutical metered dose inhaler and methods relating thereto
Metering valves for use in a metered dose inhaler that include a valve body, a first stem seal including a first elastomeric material, a second stem seal including a second elastomeric material different from the first elastomeric material, and a valve stem slidably engaged with at least one of the first stem seal and the second stem seal as well as sealed containers configured to contain an aerosol pharmaceutical formulation that include a container having an opening therein, a cap covering the opening in the container, a metering valve adjacent the cap, and a cap seal positioned between the cap and the container to provide a sealed container where the metering valve include at least one stem seal that includes a first elastomeric material, and the cap seal includes a second elastomeric material different from the first elastomeric material are described.. .
Glaxo Group Limited


 Method and devices for manufacturing and delivering of aerosolized formulations patent thumbnailMethod and devices for manufacturing and delivering of aerosolized formulations
An aerosolized formulation for use in a metered dose inhaler is disclosed which includes at least one active ingredient, at least one solvent, and at least one propellant. None of the at least one active ingredient, the at least one solvent and the at least one propellant include water..

 Treprostinil administration by inhalation patent thumbnailTreprostinil administration by inhalation
Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients.
United Therapeutics Corporation


 Aerosol delivery system patent thumbnailAerosol delivery system
Ventilator circuit aerosol delivery systems used to administer medication to a patient are disclosed. In one implementation, a metered dose inhaler (“mdi”) ventilator assembly may include a housing that defines an interior space, an inhalation port that defines an inhalation passageway in communication with the interior space, an exhalation port that defines an exhalation passageway in communication with the interior space, a patient port that defines a patient passageway in communication with the interior space, and a mdi receptacle positioned on the housing and in communication with the interior space.
Trudell Medical International


 Metered dose inhaler applicator patent thumbnailMetered dose inhaler applicator
A metered dose inhaler (“mdi”) applicator is disclosed that includes a carrier, a housing, an adjuster and a lever. The carrier defines an aperture configured to receive a boot of a mdi.
Trudell Medical International


 Composition comprising salbutamol sulphate patent thumbnailComposition comprising salbutamol sulphate
A pharmaceutical composition is described that is suitable for delivery from a pressurised container. The composition is preferably free of polar excipients and comprises: (a) a propellant component that consists essentially of 1,1-difluoroethane (r-152a); (b) a surfactant component that comprises at least one surfactant compound other than oleic acid; and (c) a drug component that consists of salbutamol sulphate.
Mexichem Amanco Holding S.a. De C.v.


Training device


The present invention provides a training device for training a user to use a pressurised metered dose inhaler (pmdi). The device comprises a body, air expulsion means (e.g.
Clement Clarke International Limited


Canister for a metered dose inhaler and producing such canister


The invention relates to a canister for a metered dose inhaler for storing a propellant and a medicament under pressure and dispensing said medicament and to a method of producing such a canister. The canister (1) comprises an interior cavity (5) defined by a tubular sidewall (2) defining a longitudinal axis (4) of the canister (1), and a bottom wall (3) and a top cover (15) closing opposite longitudinal ends of the sidewall (2) such that the sidewall (2) extends along the longitudinal axis (4) between the bottom wall (3) and the top cover (15).
Presspart Gmbh & Co., Kg


Dose indicators


The present disclosure relates to a dose indicator for a pressure-actuated metered dose inhaler (pmdi) device. In an embodiment, the dose indicator comprises a chassis element having a viewing portion, a display element located within the chassis element, a resilient deformable element, and an indexing element having an axis, translation of the indexing element along its axis from a first position to a second position causing deformation of the resilient deformable element in the same direction as translation of the indexing element resulting in generally greater displacement of portions of the resilient deformable element nearer to the axis relative to portions thereof further from the axis, the displacement of the portions of the resilient deformable element in the same direction as translation of the indexing element inducing indexing of the display element from a current position to a subsequent position relative to the viewing portion of the chassis element..
3m Innovative Properties Company


Dose counter for inhaler and counting doses


A dose counter for a metered dose inhaler includes an incremental counting system for counting doses. The incremental counting system has a main body, an actuator arranged to be driven in response to canister motion and to drive an incremental output member in response to canister motion.
Teva Pharmaceuticals Ireland


Administration of dihydroergotamine mesylate particles using a metered dose inhaler


Disclosed are compositions of matter and related methods that provide a metered dose inhaler that includes a formulation having a dose that comprises a hydrofluoroalkane propellant and dihydroergotamine mesylate particles; wherein the dose includes between 0.1 mg to 4 mg of dihydroergotamine mesylate; wherein the dihydroergotamine mesylate particles have a cumulative drug substance particle size distribution with d10>0.5 micron volumetric median diameter and d90<5.0 micron volumetric median diameter.. .
Map Pharmaceuticals, Inc.


Dose counter for inhaler having an anti-reverse rotation actuator


An incremental dose counter for a metered dose inhaler having a body arranged to retain a canister for movement of the canister relative thereto, the incremental dose counter having a main body, an actuator arranged to be driven and to drive an incremental output member in a count direction in response to canister motion, the actuator being configured to restrict motion of the output member in a direction opposite to the count direction.. .
Teva Pharmaceuticals Ireland


Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination


Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in an aerosol can provided with a metering valve having at least a butyl rubber gasket.. .
Chiesi Farmaceutici S.p.a.


Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination


Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof or a solvate of said salt, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in a can internally coated by a resin comprising a fluorinated ethylene propylene (fep) polymer.. .
Chiesi Farmaceutici S.p.a.


Dose counters for inhalers, inhalers and methods of assembly thereof


A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.. .
Norton Waterford


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Compositions, methods & systems for respiratory delivery of three or more active agents


Pharmaceutical compositions, systems and methods suitable for respiratory delivery of a fixed combination of lama, laba, and ics active agents are described. The pharmaceutical compositions described herein may be formulated for respiratory delivery via a metered dose inhaler (mdi).
Pearl Therapeutics, Inc.


Metered dose dispensing valve


The present disclosure relates to a metered dose dispensing valve for dispensing metered volumes of an aerosol formulation from an aerosol container. The valves described herein are particularly suitable for use with metered dose inhalers for the oral delivery of medicaments.
3m Innovative Properties Company


Aerosol medication inhalation system


An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject..
Pre Holding, Inc.


Spray analysis system and method


A spray measuring device/system and method can include a device, and the use of the device, that incorporates an actuation device, an illumination device, and a camera that obtains data relative to a spray event via a single exposure of the camera shutter. The actuation device can be configured to actuate a spray device such as a metered dose inhaler to create a spray event.
Innovasystems, Inc.


Levalbuterol salt


Levalbuterol l-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.. .
Sunovion Pharmaceuticals Inc.


Compositions for pulmonary delivery of long-acting b2 adrenergic receptor agonists and associated methods and systems


Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting β2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium..
Pearl Therapeutics, Inc.


Compositions, methods & systems for respiratory delivery of two or more active agents


Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium..
Pearl Therapeutics, Inc.


Compositions, methods and systems for respiratory delivery of two or more active agents


Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium..
Pearl Therapeutics, Inc.


Inhaler comprising a tiotropium-containing-composition


This invention relates to a pressurised metered dose inhaler comprising a canister, wherein the canister contains a formulation comprising a tiotropium salt and an hfa propellant, wherein the inhaler is an inhalation-actuated inhaler.. .
Teva Branded Pharmaceutical Products R&d, Inc.


Combination therapy for copd


Aerosol formulations comprising glycopyrronium chloride in combination with formoterol may be administered by means of a pressurized metered dose inhaler (pmdi) for the prevention or treatment of chronic obstructive pulmonary disease. The formulation further comprises a hfa propellant, a co-solvent, and an amount of inorganic acid sufficient to stabilize both the glycopyrronium chloride and the formoterol components.

Particulate materials


Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing such particles or formulations. In one embodiment, a composition of an aerosol formulation is provided and contains a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 μm suspended in a hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v.

Metered dose inhaler applicator


A metered dose inhaler (“mdi”) applicator is disclosed that includes a carrier, a housing, an adjuster and a lever. The carrier defines an aperture configured to receive a boot of a mdi.

Medicinal aerosol formulations


The present invention provides a process for making a stabilized medical aerosol suspension formulation for administration by a pressurized metered dose inhaler.. .

Manufacture of medicinal aerosol canisters


The present invention relates to methods of making medicinal aerosol canisters (10), in particular metered dose canisters (10), comprising aerosol formulation comprising medicament particles suspended in liquid propellant, for example for delivery by pulmonary or nasal inhalation as well as medicinal dispensers (100) including such canisters (10), such as metered dose medicinal dispenser in particular pressurized metered dose inhalers, wherein the liquid propellant in some embodiments contains hfa 134a and/or hfa 227, and the propellant component is subjected to one or more ultrasonic probes.. .

Compositions comprising salbutamol sulphate


A surfactant-free pharmaceutical composition is described. The composition consists essentially of: (a) a drug component consisting of salbutamol sulphate; and (b) a propellant component consisting essentially of 1,1-difluoroethane (r-152a).

Pharmaceutical compositions


A pharmaceutical solution for a medication delivery apparatus, especially a metered dose inhaler, is described. The pharmaceutical solution comprises: (a) a liquefied propellant component consisting essentially of and preferably consisting entirely of 1,1-difluoroethane (r-152a); (b) ethanol; and (c) a drug component dissolved in the propellant/ethanol mixture consisting of at least one drug selected from the group consisting of beclomethasone dipropionate (bdp) and fluticasone propionate (fp)..

Compositions comprising salbutamol sulphate


A pharmaceutical composition is described that is suitable for delivery from a pressurised container. The composition is free of polar excipients and comprises: (a) a propellant component that consists essentially of 1,1-difluoroethane (r-152a); (b) a surfactant component that comprises oleic acid; and (c) a drug component that consists of salbutamol sulphate.

Metered dose inhaler with an electronic dose counter


A metered dose inhaler with an electronic dose counter, and method of operating and forming the same. In one embodiment, the metered dose inhaler includes a pressurized canister assembly formed with a memory device affixed thereto.

Housing for an oral hygiene and medication device, and an assembly thereof


The invention provides a housing adapted to provide for the juxtaposition of an oral hygiene device, such as a toothbrush, with an inhaler medication device, such as a metered dose inhaler (mdi) or dry powder inhaler (dpi). Also provided is an assembly including a housing, an oral hygiene device and an inhaler medication device wherein, in use, the housing and inhaler medication device together secure the oral hygiene device in the housing such that the oral hygiene device cannot be removed for use without first removing the inhaler medication device..

A dose counter


The present invention relates to a dose counter. Particularly, but not exclusively, the invention relates to a dose counter for use with a metered dose inhaler (mdi).

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Dose counter with lockout mechanism


A medicament dispenser, in particular a metered dose inhaler, which is able to count the number of time the dispenser is activated and then disable the device, which then prevents any additional medicament from being dispensed. Additional embodiments include a medicament dispenser which are adapted to display either the number of activations that have occurred or the number of activations remaining..

Dose counters for inhalers, inhalers and methods of assembly thereof


A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.. .

Dose counters for inhalers, inhalers and methods of assembly thereof


A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.. .

Dose counters for inhalers, inhalers and methods of assembly thereof


A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.. .

Dose counters for inhalers, inhalers and methods of assembly thereof


A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.. .

Metered-dose inhaler counter and metered-dose inhaler including such a counter


A dose counter for a metered dose inhaler has an activation valve at a valve end of the metered dose inhaler. The dose counter includes a housing having a first end and an opposing second end.

Particulate materials


Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing such particles or formulations. In one embodiment, a composition of an aerosol formulation is provided and contains a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 μm suspended in a hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v.

Dose counter and recording method


A dose counter for a metered dose inhaler includes a force sensor, an electronic controller, a memory for storing data indicative of a remaining number of doses and an electronic display device coupled to the controller for displaying the remaining number of doses. The dose counter is attached or integrated into a base of a canister containing medicament such that force applied to the base of the canister is registered by the force sensor, the controller being configured to measure force applied to the dose counter when depressing the canister and being responsive to measured force to decrement the remaining number of doses stored in the memory and shown on the display device..

Method and composition for treating asthma


A pharmaceutical composition, method, and article manufacture for the treatment of asthma by inhalation from a pressurized metered dose inhaler (pm di), a dry powder inhaler (dpi) or nebulizer, the composition and method being based on a combination of a short acting beta agonist (saba) and an inhaled mometasone in a form adapted to be delivered for inhalation from the mdi, dpi or nebulizer.. .

Aerosol formulations comprising formoterol fumarate dihydrate


The invention provides a method of producing a highly stable pharmaceutical aerosol suspension formulation suitable for use in a metered dose inhaler, the formulation comprising formoterol fumarate di-hydrate in suspension, a steroid in suspension, a propellant and ethanol, the method comprising the steps of drying the formoterol fumarate di-hydrate to a water content of 4.8 to 4.28%.. .

Inhalation devices and systems and methods including the same


A collapsible inhalation device for use with a metered dose inhaler (mdi) dispenser includes an outlet end member, an inlet end member and a tubular, pliable, collapsible sleeve member attached at either end to the inlet and outlet members. The outlet end member includes a mouthpiece.

Levalbuterol salt


Levalbuterol l-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.. .

Method and making aerosol cans for metered dose inhaler


A method and apparatus for forming aerosol cans for metered dose inhalers.. .

Drug delivery device


Drug delivery devices are described that include sensors and processing circuitry that can detect operating events, such as flow rates and drug delivery, in various types of inhalers, such as dry powder inhalers, metered dose inhalers, nasal inhalers and nebulisers. The information determined by the processing circuitry can be used to provide feedback to the user or can be stored or transmitted for subsequent analysis.

Suspension formulations


The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurised metered dose inhaler (pmdi). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation..

Inhaler assist device


The present invention is directed to an inhaler assist device shaped and dimensioned for supporting a metered dose inhaler and an associated anti-static chamber in a manner allowing for assisted compression of the metered dose inhaler to dispense a dosage therefrom. The inhaler assist device includes an l-shaped housing assembly pivotally connected to a lever actuator.

Method and composition for treating asthma and copd


A pharmaceutical composition and method for the treatment of asthma or other respiratory disease by inhalation from a pressurized metered dose inhaler (pmdi), a dry powder inhaler (dpi) or nebulizer, the composition and method being based on a combination of a short acting beta agonist (saba) and an inhaled corticosteroid (ics) in a form adapted to be delivered for inhalation from the pmdi, dpi or nebulizer.. .

Process for providing a filled canister for an inhaler


A process for filling a canister for an inhaler is provided. The canister may be filled with components of a medicament.

Stabilized metered dose inhaler


Pharmaceutical pressurized metered dose inhalers are disclosed having improved temperature and moisture stability comprising cfc-free, ethanol-free compositions that include lactose of particle diameter larger than 1 μm as a means of minimizing sticking to the walls and other destabilization mechanisms activated by moisture ingress from the environment.. .

Compositions, methods & systems for respiratory delivery of two or more active agents


Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium..

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Metered dose inhaler


The present invention relates to metered dose inhaler devices for the administration of medicament to patients for inhalation therapy. Particularly, it discloses a metered dose inhaler device for improving medicament compliance by patients..

Combination mdi and nebulizer adapter for a ventilator system


An improved medication introducing device for airtight connection in a ventilation circuit or similar emergency respiratory device, including an endo-tracheal tube, the device comprising a tubular manifold including an upstream opening, a downstream opening, a top opening for an mdi (metered dose inhaler) device connection and a bottom opening for a mini-nebulizer device connection. This system provides quick and easy to use ports in a one piece component for introduction of medications and drugs to patients for which an intravenous line cannot be established.

Process for producing metered dose inhaler formulations


Disclosed are methods of introducing a suspension or solution of a medicament, preferably mometasone furoate anhydrous, into a metered dose inhaler container.. .

Dispenser with a rattle


A metered dose inhaler (1) has a pressed aluminium vessel, to which is crimped at a neck (2) a valve housing (3) having a dispensing spout (4). Within the vessel is a piston (5), urged by a spring 6 into contact with the medicament liquid (7).

Levalbuterol salt


Levalbuterol l-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.. .



Metered Dose Inhaler topics:
  • Metered Dose Inhaler
  • Respiratory
  • Levalbuterol
  • Clinical Trials
  • Clinical Trial
  • Mometasone Furoate
  • Suspension Formulation
  • Respiratory Disease
  • Corticosteroid
  • Beta Agonist
  • Compliance
  • Intravenous Line
  • Downstream
  • Intravenous
  • Ventilation


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