|| List of recent Mass Spectrometry-related patents
| Method and system for filtering gas chromatography-mass spectrometry data|
This invention relates to a system for and a method of filtering at least a part of gas chromatography-mass spectrometry data, the method comprising: providing gas chromatography-mass spectrometry data (301) for a gas mixture comprising data representing one or more gas chromatography elution peaks obtained for at least one sample, and filtering the gas chromatography-mass spectrometry data (301) to reduce the amount of data, wherein the filtering comprises taking into account predetermined data representing one or more elution peaks previously determined to be false positives (305) and/or predetermined data representing one or elution peaks previously determined to be true positives (304). In this way, unreliable elution peaks are removed in an expedient manner reducing the amount of data e.g.
Koninklijke Philips N.v.
| Phylogenetic analysis of mass spectrometry or gene array data for the diagnosis of physiological conditions|
A universal data-mining platform capable of analyzing mass spectrometry (ms) serum proteomic profiles and/or gene array data to produce biologically meaningful classification; i.e., group together biologically related specimens into clades. This platform utilizes the principles of phylogenetics, such as parsimony, to reveal susceptibility to cancer development (or other physiological or pathophysiological conditions), diagnosis and typing of cancer, identifying stages of cancer, as well as post-treatment evaluation.
| Method of detecting at least one mechanism of resistance to carbapenems by mass spectrometry|
The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a carbapenem, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism..
|Systems and methods for sequential windowed acquisition across a mass range using an ion trap|
Systems and methods are provided to perform sequential windowed acquisition of mass spectrometry data. A mass range and a mass window width parameter are received for a sample.
Dh Technologies Development Pte. Ltd.
|Performing chemical reactions and/or ionization during gas chromatography-mass spectrometry runs|
A gas chromatography-mass spectrometry (gc-ms) method that includes performing a first gc-ms run on a sample using a gas chromatography-mass spectrometry system. Performing the first gc-ms nm includes i) passing a first flow of a carrier gas carrying a first portion of the sample through a gas chromatograph to provide a first effluent; ii) generating first ions under protonation conditions by passing the first effluent through an atmospheric pressure ionization source; iii) passing the first ions through a mass spectrometer; and iv) recording first gc-ms data for the first ions.
Waters Technologies Corporation
|Method of identification of spore-forming bacillus spp. by direct in-situ analysis of maldi-tof mass spectrometry, and analysis system|
A method of the identification of bacillus species by direct in-situ analysis of maldi-tof ms (matrix-assisted laser desorption/ionization time-of-flight mass spectometry) in which spore-forming bacteria are applied intact without any pretreatment, and an analysis system of distinctive biomarkers which allow bacillus spores to be distinguished. Rapid and accurate detection and identification of bacillus species can be achieved by the method and analysis system..
Agency For Defense Development
|Collision cell for tandem mass spectrometry|
A method and apparatus for tandem mass spectrometry is disclosed. Precursor ions are fragmented and the fragments are accumulated in parallel, by converting an incoming stream of ions from an ion source (10) into a time separated sequence of multiple precursor ions which are then assigned to their own particular channel of a multi compartment collision cell (40).
Thermo Fisher Scientific (bremen) Gmbh
|Electrostatic mass spectrometer with encoded frequent pulses|
A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
|Method for imaging mass analysis using physical vapor deposition of platinum nanoparticles|
Specifically, the present invention provides a method for imaging mass spectrometry using a sample prepared by physical vapor depositing platinum nanoparticles on the surface of a test sample to be subjected to imaging mass spectrometry.. .
|Mass spectrometry analysis of microorganisms in samples|
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
Purdue Research Foundation
Method for determining the maximum mass peak in mass spectrometry
A fast method for determining molecular mass using mass spectrometry has the following steps: specifying a first adjusting value (m1) of the mass spectrometer, recording the associated signal amplitude (a1), specifying a second adjusting value (m2) which is different to the first, measuring the associated second signal amplitude (a2), specifying a third adjusting value (m3) which is different to the first (m1) and the second (m2) adjusting value, measuring the associated third signal amplitude (a3), determining a quadratic function containing the measured amplitude values as y-values and the specified adjusting values as x-values, determining the maximum of the quadratic function, wherein the searched adjusting value is determined from the x-value of the maximum.. .
A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component.
Micromass Uk Limited
System and quantitation in mass spectrometry
A method of operating a tandem mass spectrometer system is disclosed including accumulating ions in an ion trap, transmitting a plurality of ions out of the ion trap into a timed-ion selector, applying a pulsed dc voltage to the timed-ion selector, the pulsed dc voltage being modulated to match an ejection time for selecting a first portion of ions from the plurality of ions, corresponding to a specific m/z window, transmitting the first portion of selected ions out of the timed-ion selector into a reaction cell, transmitting dissociation product ions and the remaining ions of the first portion of selected ions out of the reaction cell into a mass analyzer, and mass-selectively transmitting at least some of the fragment ions and the remaining ions of the first portion of selected ions out of the mass analyzer into a detector.. .
Dh Technologies Development Pte. Ltd.
Ionization with femtosecond lasers at elevated pressure
The present disclosure generally provides ionization methods and devices for use in mass spectrometry. In some embodiments, the ionization methods and devices employ short laser pulses (e.g., pulses having pulsewidths in a range of about 2 fs to about 1 ps) at a high intensity (e.g., an intensity in a range of about 1 tw/cm2 to about 1000 tw/cm2) to ionize an analyte an ambient pressure greater than about 10−5 torr (e.g., an ambient pressure in a range of about 1 atmosphere to about 100 atmospheres)..
National Research Council Of Canada
Pulsed mass calibration in time-of-flight mass spectrometry
A method is provided for calibrating mass-to-charge ratio measurements obtained from a time-of-flight mass spectrometer used as a detector for a chromatographic system. The method can include introducing a calibrant material into the time-of-flight mass spectrometer after a sample is introduced to the chromatographic system, but before the analysis of the sample is complete, such that calibrant material and sample material are not present at the ion source of the mass spectrometer, contemporaneously, and back-flushing residual or leaking calibrant through a back-flush line and away from the mass spectrometer..
Photocured product and producing the same
It is intended to provide a photocured product that is prepared using the photo-imprint method and has favorable pattern precision and improvement in pattern defects. The present invention provides a photocured product obtained by irradiating a coating film in contact with a mold with light, the photocured product containing a fluorine atom-containing surfactant, wherein of secondary ion signals obtained by the surface analysis of the photocured product based on time-of-flight secondary ion mass spectrometry, the intensity of a c2h5o+ ion signal is higher than that of a c3h7o+ ion signal..
Canon Kabushiki Kaisha
Method for detecting delta haemolysin of staphylococcus aureus by mass spectrometry directly using a bacterial population
The present invention relates to a method for studying a sample containing a bacterial population of staphylococcus aureus with a specific mass spectrometry technique allowing specific detection on the obtained mass spectrum of the presence or of the absence of a peak at an m/z value of 3005±5 th thomson or at 3035±5 th thomson, and accordingly, to the issuance of a decision conditioned by this result.. .
Fast switching, dual polarity, dual output high voltage power supply
Systems, devices, circuits, and methods are provided for an improved mass spectrometry detection system that comprises an ion source and a detector that operate at opposite polarities. In some embodiments, the system can comprise a positive and negative multiplier, each of which can be configured to provide voltage to each of the ion source and the detector.
Dh Technologies Development Pte. Ltd.
Dual polarity spark ion source
Devices and techniques for ion analysis, including ion mobility separation and mass spectrometry, are provided using a dual polarity spark ion source and having the flexibility required to optimize the detection performance for a broad range of illicit substances with different physical and chemical properties. In various embodiments, the volatility and electro-chemical aspects may be addressed by the system described herein by performing real-time detection of compounds detectable in both positive and negative polarities and/or prioritizing spectra acquisition in a given polarity due to the high volatility and therefore short residence of certain target compounds..
Implant Sciences Corporation
Maldi mass spectrometry of peptides
The present invention provides a mass spectrometry method capable of detecting a smaller amount of peptide. A method for analyzing a peptide by matrix-assisted laser desorption/ionization mass spectrometry, comprising the steps of: dropping, onto a target plate, a peptide solution using, as a solvent, an aqueous solution containing 15 to 50 vol % of acetonitrile, and a matrix solution that uses, as a solvent, an aqueous solution containing 15 to 50 vol % of acetonitrile and that contains 0.05 to 1 mg/ml α-cyano-4-hydroxycinnamic acid, respectively, to prepare a droplet of peptide-matrix mixed solution; removing the solvent from the droplet of peptide-matrix mixed solution to prepare a sample for mass spectrometry as a residue; and irradiating the sample for mass spectrometry with laser to detect the peptide..
Method of processing spectrometric data
A method of characterising a sample from spectrometric data using calculation of spectral distance values is disclosed, for use in the field of mass spectrometry. Molecular formula assignment of peaks in mass spectral data is difficult and time-consuming, and the invention provides a computer implemented method of finding a most likely elemental composition of a measured spectral peak of interest.
Thermo Fisher Scientific (bremen) Gmbh
Quantification of impurities for release testing of peptide products
The present invention relates to a method for the quantitative determination of an impurity present in a peptide product, wherein the impurity cannot be separated from other impurities or the main product. The method particularly involves the use of high resolution mass spectrometry (ms) detection with or without high performance liquid chromatography (hplc).
Sanofi-aventis Deutschland Gmbh
Ion extraction ion trap mass spectrometry
A method is provided for processing ions in a multipole ion trap, comprising generating rf radial confinement fields within a first and second multipole rod set positioned in tandem, a ratio of q value exhibited by the second rod set relative to the first rod set being greater than one for any m/z, said rf axial confinement fields within the first and second rod sets interacting in an interaction region between the first and second rod sets so as to produce a fringing field; transmitting ions through said first rod set towards said second rod set; and increasing the radial oscillation amplitude of at least a portion of the ions within said first rod set such that at least a portion of said ions having an increased radial oscillation amplitude are repulsed by said fringing field.. .
Dh Technologies Development Pte. Ltd.
Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method
Provided is an ion group irradiation device for facilitating the distinction of peaks in secondary ion mass spectra. The ion group irradiation device for irradiating a sample with an ion group includes an ion source for generating ions, an ion group selecting unit configured to select, from the ions released from the ion source, two or more ion groups formed of ions having different average masses, and a primary ion irradiation unit configured to irradiate the sample with the two or more ion groups.
Canon Kabushiki Kaisha
Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method
The present invention provides an ion group irradiation device for irradiating a sample with an ion group, comprising: an ion group selecting unit configured to select, from ions released from an ion source, at least two ion groups formed of ions having different average masses; and a primary ion irradiation unit configured to irradiate the sample with the at least two ion groups selected by the ion group selecting unit, wherein the ion group selecting unit selects at least one ion group and further selects the at least two ion groups from each of the selected at least one ion group.. .
Canon Kabushiki Kaisha
Systems and methods for discovery and analysis of markers
A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state.
Electron ionization (ei) utilizing different ei energies
Mass spectrometry is performed utilizing an electron ionization (ei) source. The ei source ionizes a sample at different electron energies, including below and above 70 ev.
Agilent Technologies, Inc.
Use of detection techniques for contaminant and corrosion control in industrial processes
Industrial fluids may be monitored at the site of each industrial fluid by introducing a sample of the industrial fluid into a device employing a detection technique for detecting at least one composition within the sample. The detection technique may be or include surface enhanced raman scattering (sers), mass spectrometry (ms), nuclear magnetic resonance (nmr), ultraviolet light (uv) spectroscopy, uv spectrophotometry, indirect uv spectroscopy, contactless conductivity, laser induced fluorescence, and combinations thereof.
Baker Hughes Incorporated
Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards
A method for absolute protein or peptide quantitation by mass spectroscopy. A sample containing a protein or peptide of interest is prepared for mass spectroscopy analysis.
Methods for identifying protein-protein interactions
The invention generally relates to methods for identifying protein-protein interactions. In certain aspects, methods of the invention involve conducting a protein-fragment complementation assay on a sample to form a protein-protein complex between two proteins in the sample that only transiently interact under physiological conditions, separating the complexes from the sample, and analyzing a protein of the complex using a mass spectrometry technique..
Imaging mass spectrometer and a mass spectrometry
An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process.. .
Methods for detecting lacosamide by mass spectrometry
Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample..
Methods for simultaneous quantification of thyroid hormones and metabolites thereof by mass spectrometry
The invention provides methods for simultaneously detecting or simultaneously quantifying any combination of thyroxine (t4), triiodothyronine (t3), 3,3′-diiodo-l-thyronine (3,3′-t2), 3-iodothyronamine (t1am), and, optionally, reverse t3 (rt3) in a sample obtained from a human. The method involves a simple, sensitive, accurate, and specific isotope dilution tandem mass spectrometry method for the simultaneous quantification of any combination of t4, t3, 3,3′-t2, t1am, and, optionally, rt3 in a sample obtained from a human, e.g., in human plasma or serum samples.
Fractional abundance estimation from electrospray ionization time-of-flight mass spectrum
Methods and systems for detecting and quantifying signal peaks from esi-tof-ms data may include creating a signal model and a noise model for mass spectrometry (ms) data. The method may also include detecting a signal peak based, at least in part, on the signal model and the noise model for the ms data.
Method for identifying microorganisms by mass spectrometry
A method of identifying a microorganism by mass spectrometry, including acquiring at least one mass spectrum of said microorganism; for each acquired mass spectrum: detecting peaks of the spectrum in a predetermined mass range; generating a list of peaks identifying at most one peak in each interval of a predetermined subdivision of the range of mass-to-charge ratios, the width of the intervals of the subdivision logarithmically increasing along with the mass-to-charge ratio, and analyzing the list(s) of peaks obtained according to a knowledge base of previously-identified microorganisms and/or types of microorganisms.. .
Hydrogel-mediated tissue analysis
A method for analyzing the polypeptide content of animal tissue is described. The method includes the steps of (a) providing an animal tissue specimen; (b) depositing one or more portions of a hydrogel mixture including a protease on spatially discrete portions of the animal tissue specimen; (c) allowing sufficient time to pass for animal tissue under the hydrogel mixture to be form a digested mixture of animal tissue and hydrogel mixture; (d) removing the digested mixture from the animal tissue and extracting the polypeptides from the digested mixture to provide an extract; and (e) analyzing the polypeptide content of the extract by mass spectrometry..
Method and system for analyzing protein or peptide
A peptide is cleaved at various bonding sites into oligopeptides or similar fragments by digestion using proteinase k (s3). The obtained fragments are separated according to their kinds by reversed-phase chromatography and fractionated (s4), and each fragment is subjected to mass spectrometry to determine its mass (s6).
Ion mobility spectrometry-mass spectrometry (ims-ms) with improved ion transmission and ims resolution
An interface for an ion mobility spectrometry-mass spectrometry (ims-ms) system includes a first ion guide for receiving ions from an ims drift cell, and a second ion guide for receiving ions from the first ion guide, and positioned in a chamber separate from the first ion guide. Electrodes of the second ion guide subject the ions to an axial dc electric field while the second ion guide is held at a lower pressure than the first ion guide.
Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid
The invention relates to the detection of dha and epa. In a particular aspect, the invention relates to methods for detecting dha and epa by mass spectrometry and kits for carrying out such methods..
Mass spectrometry improved multiple reaction monitoring
The present teachings are directed to methods and apparatuses for mass spectrometry that include configuring mass spectrometry apparatus to perform a plurality of separate assays on ions fragmented from a given analyte, where each such analysis by the spectrometry apparatus is targeted at a different respective associated mass-to-charge ratio and provides a quantitative measure of the number of fragments thereof.. .
Measurement plate for maldi mass spectrometry
A measurement plate 10 for maldi mass spectrometry consists of a base plate 11 having an upper surface and a carbon sheet 12 laid on at least a portion of the upper surface. The carbon sheet 12 is a highly-oriented graphite sheet with the orientation direction being parallel to the upper surface.
Strategic dynamic range control for time-of-flight mass spectrometry
A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters.
Enhancement of sensitivity and specificity of ketosteroids and keto or aldehyde containing analytes
A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological matrices.
Micro-sampling for aquatic chemical analysis
The current invention describes in vivo and vitro (cultured) sampling technologies that allow direct temporal and spatial sampling from living ecosystems such as those associated with marine ecology. The optional use of parallel sampling methods, observatory design, provides for the ability to measure the response of individual organisms to a variety of both biotic and abiotic stresses.
Circuit for generating a voltage waveform
A circuit for generating a voltage waveform at an output node. The circuit includes a voltage rail connected to the output node via a voltage rail switch; an anchor node connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes two or more transistors connected in series; and a control unit configured to change the voltage at the output node by controlling the voltage rail switch and the bidirectional switch so that, if a load capacitance is connected to the output node, a resonant circuit is established between the inductor and the load capacitance.
Ion detecting apparatus
There is no small ion detecting apparatus that quickly and easily performs mass spectrometry under atmospheric pressure. Therefore, in order to solve the problem, an electrode arrangement and an electrode holding form for enabling water clusters in outside air to be detected with high sensitivity are provided.
Method of tandem mass spectrometry
A method of tandem mass spectrometry is disclosed. A quasi-continuous stream of ions from an ion source (20) and having a relatively broad range of mass to charge ratio ions is segmented temporally into a plurality of segments.
Direct measurements of nanoparticles and virus by virus mass spectrometry
Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages..
Method for identifying microorganisms via mass spectrometry and score normalization
Where: m is the distance calculated for the reference microorganism; n(m. .
μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; n(m
Aluminum-polymer resin composite and producing the same
Disclosed is an aluminum-polymer resin composite. The composite includes i) aluminum and ii) a polymer resin bonded to the aluminum after modification of the aluminum surface with at least one surface modifier selected from the group consisting of sulfur-containing diazole derivatives, sulfur-containing diamine derivatives, sulfur-containing thiol derivatives, sulfur-containing pyrimidine derivatives, and sulfur-containing silane coupling agents.
Multinotch isolation for ms3 mass analysis
A mass spectrometry method for analyzing isobarically-labeled analyte compounds comprising (a) ionizing compounds including the isobarically-labeled analyte compounds to generate a plurality of precursor ion species comprising different respective m/z ratios, (b) isolating a precursor ion species, (c) fragmenting the precursor ion species to generate a plurality of first-generation fragment ion species comprising different respective m/z ratios, and (d) selecting and co-isolating two or more of the first-generation product-ion species, the method characterized by: (e) fragmenting all of the selected and isolated first-generation product ion species so as to generate a plurality of second-generation fragment ion species including released label ions; (f) generating a mass spectrum of the second-generation fragment ion species; and (g) generating quantitative information relating to at least one analyte compound based on peaks of the mass spectrum attributable to the released label ions.. .
Systems, devices, and methods for sample analysis using mass spectrometry
A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer.
Identification of related peptides for mass spectrometry processing
A method of identifying a related peak set from ms1 spectra data is provided. An intensity peak is selected from ms1 spectra data generated for a sample by a tandem mass spectrometer.
Srm/mrm assay for the ephrin typa-a receptor 2 protein
Specific peptides, and derived ionization characteristics of the peptides, from the ephrin type-a receptor 2 (epha2) protein are provided that are particularly advantageous for quantifying the epha2 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Single crystal cvd synthetic diamond material
A single crystal cvd synthetic diamond material comprising: a total as-grown nitrogen concentration equal to or greater than 5 ppm, and a uniform distribution of defects, wherein said uniform distribution of defects is defined by one or more of the following characteristics: (i) the total nitrogen concentration, when mapped by secondary ion mass spectrometry (sims) over an area equal to or greater than 50×50 μm using an analysis area of 10 μm or less, possesses a point-to-point variation of less than 30% of an average total nitrogen concentration value, or when mapped by sims over an area equal to or greater than 200×200 μm using an analysis area of 60 μm or less, possesses a point-to-point variation of less than 30% of an average total nitrogen concentration value; (ii) an as-grown nitrogen-vacancy defect (nv) concentration equal to or greater than 50 ppb as measured using 77k uv-visible absorption measurements, wherein the nitrogen-vacancy defects are uniformly distributed through the synthetic single crystal cvd diamond material such that, when excited using a 514 nm laser excitation source of spot size equal to or less than 10 μm at room temperature using a 50 mw 46 continuous wave laser, and mapped over an area equal to or greater than 50×50 μm with a data interval less than 10 μm there is a low point-to-point variation wherein the intensity area ratio of nitrogen vacancy photoluminescence peaks between regions of high photoluminescent intensity and regions of low photolominescent intensity is <2× for either the 575 nm photoluminescent peak (nv0) or the 637 nm photoluminescent peak (nv); (iii) a variation in raman intensity such that, when excited using a 514 nm laser excitation source (resulting in a raman peak at 552.4 nm) of spot size equal to or less than 10 μm at room temperature using a 50 mw continuous wave laser, and mapped over an area equal to or greater than 50×50 μm with a data interval less than 10 μm, there is a low point-to-point variation wherein the ratio of raman peak areas between regions of low raman intensity and high raman intensity is <1.25×; (iv) an as-grown nitrogen-vacancy defect (nv) concentration equal to or greater than 50 ppb as measured using 77k uv-visible absorption measurements, wherein, when excited using a 514 nm excitation source of spot size equal to or less than 10 μm at 77k using a 50 mw continuous wave laser, gives an intensity at 575 nm corresponding to nv0 greater than 120 times a raman intensity at 552.4 nm, and/or an intensity at 637 nm corresponding to nv− greater than 200 times the raman intensity at 552.4 nm; (v) a single substitutional nitrogen defect (ns) concentration equal to or greater than 5 ppm, wherein the single substitutional nitrogen defects are uniformly distributed through the synthetic single crystal cvd diamond material such that by using a 1344 cm−1 infrared absorption feature and sampling an area greater than an area of 0.5 mm2, the variation is lower than 80%, as deduced by dividing the standard deviation by the mean value; (vi) a variation in red luminescence intensity, as defined by a standard deviation divided by a mean value, is less than 15%; (vii) a mean standard deviation in neutral single substitutional nitrogen concentration of less than 80%; and (viii) a colour intensity as measured using a histogram from a microscopy image with a mean gray value of greater than 50, wherein the colour intensity is uniform through the single crystal cvd synthetic diamond material such that the variation in gray colour, as characterised by the gray value standard deviation divided by the gray value mean, is less than 40%.. .
Methods of detecting reverse triiodothyronine by mass spectrometry
Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample..
Use of windowed mass spectrometry data for retention time determination or confirmation
A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans.
Techniques for quantification of samples
Techniques are described for quantification of molecules in a sample. Mass spectrometry is performed to obtain ionization intensities for precursor and product ions originating from a particular molecule.
Atmospheric pressure ion source for mass spectrometry
A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as atmospheric pressure chemical ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions.
Nanomanipulation coupled nanospray mass spectrometry (nms)
A coupled nanomanipulation and nanospray mass spectrometry (nms) system for single cell, single organelle, and ultra-trace molecular analysis is disclosed herein. The system primarily comprises a bio-workstation coupled to a nms.
Methods, apparatus, and system for mass spectrometry
A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments.
Diathermy knife ionisation source
A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife.
Determining the geographic origin of metals
A method of determining the geographic origin of a metal can comprise measuring a first isotope and a second isotope of the metal by high-resolution mass spectrometry; calculating a ratio of the first isotope and the second isotope; comparing the ratio to native ratios of isotopes of the metal of native samples from a plurality of geographic locations using a database; and matching the ratio to a geographic location.. .
Srm/mrm assay for the insulin receptor protein
Specific peptides, and derived ionization characteristics of the peptides, from the insulin receptor protein (ir), and its isoforms ir-a and ir-b, that are particularly advantageous for quantifying the ir protein, ir-a isoform and/or ir-b isoform, directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
There is provided an ion reflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The reflector includes an electric field capable of causing a flow of ions focused through a first spatial region to be focused toward a second spatial region, whereby the first and second spatial regions are aligned with respective axes of travel..
System and applying curtain gas flow in a mass spectrometer
A system of mass spectrometry is disclosed having an ion source for generating ions at substantially atmospheric pressure. The system has a sampling member with an orifice disposed therein.
Intelligent background data acquisition and subtraction
A scan of a separating sample mixture is received from a mass spectrometer at each interval of a plurality of intervals. It is determined at a first interval that a received mass spectrometry scan at the first interval and one or more preceding received mass spectrometry scans include a varying ion signal that represents an ion of a known compound and has an intensity above a threshold level.
New use for a compound as a matrix in the specific detection, identification and/or quantification of alkaloids by maldi-tof mass spectrometry
There is provided (i) a method of analysing small molecules that may have a mass of <800 da, in particular alkaloids, said method being generally referred to as maldi-tof-ms (or maldi time-of-flight mass spectrometry), which is an acronym for a method of analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Also provided is (ii) a molecule according to formula (i) and the use of the molecule as a matrix in the analysis method..