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Mass Spectrometry patents

      

This page is updated frequently with new Mass Spectrometry-related patent applications.




 M/z targeted attenuation on time of flight instruments patent thumbnailM/z targeted attenuation on time of flight instruments
A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a time of flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the time of flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity..
Micromass Uk Limited


 An analytical apparatus utilizing electron impact ionization patent thumbnailAn analytical apparatus utilizing electron impact ionization
An analytical apparatus (1) for mass spectrometry comprises an electron impact ioniser including an electron emitter (22) and an ionisation target zone (18). The target zone (18) is arranged to be populated with matter to be ionised for analysis.
Markes International Limited


 Method to evaluate the tissue targeting of a molecule of interest patent thumbnailMethod to evaluate the tissue targeting of a molecule of interest
The invention relates to a method for evaluating if a molecule of interest binds or is incorporated in, at least one target tissue comprising visualizing and comparing the distribution of the molecule of interest and of at least one control compound within the target tissue or on the target tissue surface of at least one animal that has previously received the molecule of interest and/or the control compound. Advantageously, the distribution of the molecule of interest is visualized and compared with the distribution of positive and negative compounds using mass spectrometry imaging on the surface of the target tissue..
Imabiotech


 Fully automated analytical  determination of chloroethers in water and urine sample patent thumbnailFully automated analytical determination of chloroethers in water and urine sample
A fully automated flow assisted-solid-phase microextraction (fa-spme) is developed for the determination of chloroethers in aqueous samples. A ctc combipal autosampler coupled with gas chromatography-mass spectrometry (gc-ms) is used to automate the extraction process.
King Abdulaziz City For Science And Technology


 Srm assay to indicate cancer therapy patent thumbnailSrm assay to indicate cancer therapy
The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the alk, ros, ron, ret, ts, and/or fgfr1 proteins that are particularly advantageous for quantifying the alk, ros, ron, ret, ts, and/or fgfr1 proteins directly in biological samples that have been fixed in formalin by the methods of selected reaction monitoring (srm) mass spectrometry, or as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


 Method and device for mass spectrometry patent thumbnailMethod and device for mass spectrometry
A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part.
Hitachi High-technologies Corporation


 Her3 protein srm/mrm assay patent thumbnailHer3 protein srm/mrm assay
The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the receptor tyrosine-protein kinase erbb-3, or her3, that are particularly advantageous for quantifying the her3 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


 Mass spectrometry systems with convective flow of buffer gas  for enhanced signals and related methods patent thumbnailMass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods
mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for differential background pressures where p2<p1 which generates gas flow through an unsealed, sealed or partially sealed ion trap and enhances detected signal relative to when p2=p1.. .
The University Of North Carolina At Chapel Hill


 Compositions and methods for mass spectometry patent thumbnailCompositions and methods for mass spectometry
The invention provides ionizing matrix compounds. These compounds are useful for mass spectrometry and ion mobility spectrometry as ionizing matrices facilitating transfer of diverse classes of analyte compounds from solid or solution states to gas-phase ions..

 Systems and methods for single cell culture and analysis by microscopy and maldi mass spectrometry patent thumbnailSystems and methods for single cell culture and analysis by microscopy and maldi mass spectrometry
Systems and methods for single cell culture and analysis by microscopy and matrix assisted laser desorption ionization mass spectrometry are disclosed. The systems and methods isolate a plurality of cells in a plurality of wells such that a predetermined number of the plurality of wells contain one and only one cell.
Massachusetts Institute Of Technology


Data processing for multiplexed spectrometry

Multiplexed spectrometry, such as multiplexed ion mobility spectrometry (ims), time-of-flight mass spectrometry (tofms), or hybrid im-tofms, is carried out on a sample, and the resulting measurement data are deconvoluted. Noise may be removed from the measurement data prior to deconvolution.
Agilent Technologies, Inc.

Optimizing drag field voltages in a collision cell for multiple reaction monitoring (mrm) tandem mass spectrometry

A collision cell has a plurality of rod electrodes arranged in opposed pairs around an axial centerline and a plurality of drag vanes arranged in the interstitial spaces between the rod electrodes. Operating the collision cell includes, applying a rod offset voltage to the rod electrodes, and varying an offset voltage applied to the drag vanes to identify a vane offset voltage with a maximum intensity for the transition.
Thermo Finnigan Llc

Quantitative peptide or protein assay

Peptide and/or protein quantitation methods, kits, and compositions, particularly useful for mass spectrometry, are provided herein based on a bathocuproine-based composition complex such as bathocuproinedisulfonic acid disodium salt hydrate complex. The methods are one-step rapid absorbance methods using small sample volumes.
Pierce Biotechnology, Inc.

Secondary battery-use active material, secondary battery-use electrode, secondary battery, battery pack, electric vehicle, electric power storage system, electric power tool, and electronic apparatus

A secondary battery includes: a cathode; an anode; and an electrolytic solution. The cathode contains an active material capable of inserting and extracting an electrode reactant.
Sony Corporation

Laser ablation atmospheric pressure ionization mass spectrometry

In an embodiment, the present invention provides an apparatus for mass spectrometry which includes a laser ablation sampler comprising a laser ablation chamber and a laser. The laser ablation chamber is configured so that the laser can irradiate and ablate a material from a sample to generate an ablated sample material.
WestfÄlische Wilhelms-universitÄt MÜnster

Methods of validating candidate compounds for use in treating copd and other diseases

The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (copd), chronic bronchitis, emphysema, refractory asthma, and other related diseases.
The Trustees Of Columbia University In The City Of New York

Combustion pretreatment-isotope dilution mass spectrometry

Provided is a combustion pretreatment-isotope dilution mass spectrometry measuring concentration of a target element for detection contained in a target sample for detection by using an isotope dilution mass spectrometry, including: pretreating the target sample for detection by combustion during an isotope dilution mass spectrometry, to thereby stabilize an isotope and further improve analysis ability, and therefore, the present invention is expected to be utilized as an element analysis method surpassing accuracy of the existing mass spectrometry method.. .
Korea Research Institute Of Standards And Science

Imaging mass spectrometry

A method of performing imaging mass spectrometry of a sample. The method comprises performing a first mass analysis of the sample using a first mass analyzer comprising a multi-pixel ion detector to obtain first mass spectral data representative of pixels of the sample.
Thermo Fisher Scientific (bremen) Gmbh

Detection of membrane proteins

According to the present invention, there is provided a method of detecting a membrane protein by mass spectrometry, the method comprising the steps of: (a) providing a solution comprising a detergent micelle in which said membrane protein is contained, wherein said solution contains a polyoxyalkylene glycol detergent; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the micelle; (d) ionising the membrane protein; (e) resolving the ionised membrane protein using the mass analyser; and (f) detecting the resolved membrane protein using the detector. Also provided are reagents for use in said method..

C peptide detection by mass spectrometry

Methods are described for measuring the amount of c peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying c peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
Quest Diagnostics Investments Incorporated

Mass spectrometry analyses on lipid and other ions using a unique workflow

The applicants' teachings provide in some aspects methods and apparatus for mass spectrometric analysis that identify the location of carbon-carbon double bonds, if any, in an analyte by (1) obtaining the m/z ratio of the intact analyte ions, (2) subjecting these ions to collision-induced dissociation and (3) determining relationships between masses and/or mass-to-charge ratios of the intact analyte ions and the fragments produced by such collision-induced dissociation. The methods and apparatus selectively subject analyte ions to ozone-induced dissociation based on those relationships and determine location(s) of carbon-carbon double bonds, if any, from reaction products of ozone-induced dissociation..
Unversity Of Wollongong

Circuit for generating a voltage waveform

A circuit for generating a voltage waveform at an output node. The circuit includes a voltage rail connected to the output node via a voltage rail switch; an anchor node connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes two or more transistors connected in series; and a control unit configured to change the voltage at the output node by controlling the voltage rail switch and the bidirectional switch so that, if a load capacitance is connected to the output node, a resonant circuit is established between the inductor and the load capacitance.
Shimadzu Corporation

Targeted analysis for tandem mass spectrometry

A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection tof device that separates ions into packets in accordance with their m/z.
Thermo Fisher Scientific (bremen) Gmbh

High mass accuracy filtering for improved spectral matching of high-resolution gas chromatography-mass spectrometry data against unit-resolution reference databases

The invention provides methods, systems and algorithms for identifying high-resolution mass spectra. In some embodiments, an analyte is ionized and analyzed using high-resolution mass spectrometry (ms) at high mass accuracy (such as ≦75 ppm or ≦30 ppm) and the obtained mass spectra are matched with one or more prospective candidate molecules or chemical formulas.
Wisconsin Alumni Research Foundation

Diathermy knife ionisation source

A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife.
Micromass Uk Limited

Method and mass spectrometry of macromolecular complexes

A method of analyzing macromolecular complex ions, such protein complex ions, by mass spectrometry and apparatus for performing the method, wherein the method comprises: introducing macromolecular complex ions into a first fragmentation device and trapping the complex ions therein for a trapping period; fragmenting the trapped complex ions in the first fragmentation device to produce monomer subunit ions; optionally selecting one or more species of subunit ions by m/z; introducing one or more of the species of subunit ions into a second fragmentation device, spatially separated from the first fragmentation device; fragmenting the subunit ions in the second fragmentation device to produce a plurality of first fragment ions of the subunit ions; and mass analyzing the first fragment ions in a mass analyzer, or subjecting the first fragment ions to one or more further steps of fragmentation to form further fragment ions and mass analyzing the further fragment ions.. .
Thermo Fisher Scientific (bremen) Gmbh

Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid

The invention relates to the detection of dha and epa. In a particular aspect, the invention relates to methods for detecting dha and epa by mass spectrometry and kits for carrying out such methods..
Quest Diagnostics Investments Incorporated

System and analysis of bio-metabolites for-use in image-guided surgery

A system for identifying a bio-marker using mass spectroscopy is provided that includes a sample receptacle configured to receive a tissue sample, a mass spectrometry apparatus configured to receive the tissue sample and analyze the tissue sample using a mass spectrometry process to generate mass spectrometry data, and a computer system that includes a computer processor having access to a non-transitory, computer-readable storage medium having stored thereon instructions. The instructions cause the computer processor to: receive the mass spectrometry data from the mass spectrometry apparatus; analyze the mass spectrometry data to determine a presence of 2-hydroxyglutarate (2-hg) in the tissue sample; and generate a report indicating a health of the tissue sample based on the presence of 2-hg in the tissue sample..

In vitro diagnostic an invasive fungal infection using maldi-toff mass spectrometry

A method for the in vitro diagnosis of an invasive fungal infection by maldi-tof mass spectrometry. The method involves, providing a liquid biological sample from a mammal, said biological sample containing, in particular, proteins and/or lipids and/or salts and/or polysaccharides and/or oligosaccharides and/or monosaccharides capable of forming complexes with said proteins and/or lipids and/or salts; treating said sample with biological liquid so as to extract said polysaccharides and/or oligosaccharides and/or monosaccharides; determining, by maldi-tof mass spectrometry, whether or not there is present among said extracted polysaccharides, oligosaccharides and/or monosaccharides, at least one given compound of interest coming from said fungal microorganism and chosen from polysaccharides, oligosaccharides and monosaccharides; and deducing, if said given compound of interest is present in said sample, that said mammal is suffering from an invasive fungal infection..
Centre National De La Recherche Scientifique

Microsecond time-resolved mass spectrometry

A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length.
Ohio University

Sample preparation and nanoelectrospray ionization mass spectrometry

Method for loading a sample of a target compound into a nanospray emitter tube for analysis by nanospray ionization mass spectrometry, wherein a cartridge having a fluid container, an inlet and an outlet is mounted onto a nanospray emitter tube on a nanospray emitter mount to form a nanospray emitter tube assembly, the assembly is mounted on a micro-centrifuge tube, a volume of the sample to be analyzed is loaded into the fluid container and the micro-centrifuge tube is spun on a centrifuge to transfer the sample into the nanospray emitter tube.. .
New Objective, Inc.

System and maldi-tof mass spectrometry

A system and method for matrix assisted laser desorption time-of-flight (maldi-tof) mass spectrometry. A method for maldi-tof mass spectrometry includes initiating a spectral analysis of a sample on a maldi-tof spectrometer.
University Of Houston System

Compositions and methods for purification and detection of hdl and apoa1

The present invention provides methods, kits, and compositions for purifying hdl molecules from a sample (e.g., blood sample) using hdl tagging molecules comprising an hdl lipophilic core binding peptide (e.g., portion of apoa1) and an affinity tag. The present invention also provides methods, kits, and compositions for detecting non-fragmented apoa1 with mass spectrometry.
Cleveland Heartlab, Inc.

Rapid discovery and screening of enzyme activity using mass spectrometry

Described herein are methods, systems, and compositions for detecting enzyme activity. In some embodiments, the reaction product(s) are coupled with a mass tag, and the enzyme activity is determiner by analyzing the reaction product(s).
Sandia Corporation

Semiconductor device

A transistor capable of being driven at high operating frequency is provided. The transistor includes first to third oxide semiconductor layers, a gate insulating layer, a gate electrode layer, and a portion in which the first to third oxide semiconductor layers are sequentially stacked.
Semiconductor Energy Laboratory Co., Ltd.

Method for ion production

A method for producing multiply charged ions is provided. In the method, a laser is used to ablate a sample comprising a matrix and an analyte.
University Of Reading

Ultrafast transimpedance amplifier interfacing electron multipliers for pulse counting applications

Systems, devices, and methods are provided for an improved mass spectrometry detection system for pulse counting applications. The detector can comprise an electron multiplier and circuitry, such as a transimpedance amplifier, that allows for the gain of the detector to be decreased, which in turn leads to a pulse counting detector with a high dynamic range.
Dh Technologies Development Pt. Ltd.

Genetic affinity of microorganisms and viruses

Selecting which sub-sequences in a database of nucleic acid such as 16s rrna are highly characteristic of particular groupings of bacteria, microorganisms, fungi, etc. On a substantially phylogenetic tree.

Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and lc/ms/ms workflow

A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the analysis of ketosterol biomarkers such as bile acid precursors from human plasma, serum or whole blood. This method is used for new born screening for cerebrotendinous xanthomatosis (ctx).
Dh Technologies Development Pte. Ltd

Selected reaction monitoring assays

Provided herein are methods for developing selected reaction monitoring mass spectrometry (lc-srm-ms) assays.. .
Integrated Diagnostics, Inc.

Quantitation of tamoxifen and metabolites thereof by mass spectrometry

Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein comprise determining the amount of norendoxifen.
Quest Diagnostics Investments Incorporated

Non-aqueous microchip electrophoresis for characterization of lipid biomarkers

The invention provides devices and methods for the detection of hydrophobic biomarkers using 3d microchip capillary electrophoresis having a non-aqueous solvent system. Hydrophobic biomarkers can be placed in a microcapillary microchannel and electrokinetically injected into a second microcapillary microchannel through a nanocapillary array membrane.
University Of Notre Dame Du Lac

High pressure mass spectrometry systems and methods

Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.

Probe for extraction of molecules of interest from a sample

A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer.

Probe for extraction of molecules of interest from a sample

The present disclosure describes a device for generating ionized molecules for analysis in a mass spectrometer. The device includes: a mesh substrate coated with an extraction phase, the extraction phase comprising a polymer that absorbs a molecule of interest from a matrix, or a polymer and solid phase microextraction (spme) particles having pores dimensioned to absorb a molecule of interest from a matrix, where the mesh substrate has a sufficiently open structure to allow fluid to flow through the mesh substrate; and a solid substrate connected to the mesh substrate to provide stability to the coated mesh substrate.

Correction of time of flight ms adc data on push by push basis

A method of mass spectrometry is disclosed comprising pulsing ions into a time of flight region and detecting the ions using an ion detector. The signal output from the ion detector is digitised to produce a digitised signal.
Micromass Uk Limited

Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method

The present invention provides an ion group irradiation device for irradiating a sample with an ion group. An ion group selecting unit is configured to select, from ions released from an ion source, at least two ion groups formed of ions having different average masses.
Canon Kabushiki Kaisha

High sensitivity electrospray interface

The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry.
University Of Notre Dame De Lac

Ionization device, mass spectrometry apparatus, mass spectrometry method, and imaging system

A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions.. .
Canon Kabushiki Kaisha

Display device

One object is to provide a transistor including an oxide semiconductor film which is used for the pixel portion of a display device and has high reliability. A display device has a first gate electrode; a first gate insulating film over the first gate electrode; an oxide semiconductor film over the first gate insulating film; a source electrode and a drain electrode over the oxide semiconductor film; a second gate insulating film over the source electrode, the drain electrode and the oxide semiconductor film; a second gate electrode over the second gate insulating film; an organic resin film having flatness over the second gate insulating film; a pixel electrode over the organic resin film having flatness, wherein the concentration of hydrogen atoms contained in the oxide semiconductor film and measured by secondary ion mass spectrometry is less than 1×1016 cm−3..
Semiconductor Energy Laboratory Co., Ltd.

Methdos for detecting estradiol by mass spectrometry

Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample..
Quest Diagnostics Investment Inc.

Methods of analyzing crude oil

The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis.
Purdue Research Foundation

Methods of detecting reverse triiodothyronine by mass spectrometry

Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample..
Quest Diagnostics Investments, Inc.

Ion trap analyzer and ion trap mass spectrometry analysis method

An ion trap analyzer, an ion trap mass spectrometry analysis method, and an ion fragmentation method are provided. The ion trap analyzer includes an ion trapping space enclosed by multiple electrodes (101, 102, 103, 11, 12, 214), where a high-frequency voltage is applied on at least a part of the electrodes, so as to generate, within the trapping space, a trapping electric field dominated by a quadratic field.
Shimadzu Corporation

Fully automated analytical determination of chloroethers in water and urine sample

A fully automated flow assisted-solid-phase microextraction (fa-spme) is developed for the determination of chloroethers in aqueous samples. A ctc combipal autosampler coupled with gas chromatography-mass spectrometry (gc-ms) is used to automate the extraction process.
King Abdulaziz City For Science And Technology

Tissue sample preparation, and maldi ms imaging thereof

Aspects of the present invention relate to a method for the preparation of samples for maldi ms imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix.
The Brigham And Women's Hospital, Inc.

Substrates and methods for preparing samples for mass spectrometry

A mass spectrometry substrate for performing adsorption and biological processing includes a porous silica-based material comprising a chemical adsorption material that captures analyte(s) of interest. A biologically active material incorporated into the porous silica-based material performs biological processing on the analyte(s) of interest..
Virgin Instruments Corporation

Ionization of chemicals in mixture at low ph by ambient ionization/mass spectrometry

A mass spectrometry-based method for analyzing an acidic organic target compound includes directing a charged solvent (44) toward a pre-acidified sample (12) comprising the target compound, to thereby ionize the pre-acidified sample (12). The method further includes directing the ionized pre-acidified sample (54) to a mass spectrometer (18), the mass spectrometer (18) being configured to identify and quantify the target compound..

Method of diagnosing galactosemia in neonatal screening

A method of diagnosing galactosemia in blood samples from neonates by determining gal-1-p concentrations before 5-7 days of life is disclosed. The removal of interfering compounds allows a more specific and therefore more accurate determination of gal-ip levels in newborn screening for galactosermia using mass spectrometry.

Vitro assays for detecting salmonella enterica serotype typhi

Provided are assays, kits and compositions for testing subjects, particularly asymptomatic subjects, to ascertain whether or not they are carriers of salmonella enterica serotype typhi. Methods for detecting the presence of salmonella enterica serotype typhi indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided..

Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging

This disclosure provides systems, methods, and apparatus for integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter.

Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry

Embodiments are directed to a method, a computer readable medium encoded with instructions that, when executed, perform a method, and a system for performing mass spectrometry analysis. Molecules of different samples may be labeled with a chemical tag, allowing a multiplexed analysis of multiple samples.

Methods of quantifying n2-(1-carboxyethyl)-2'-deoxy-guanosine (cedg) and synthesis of oligonucleotides containing cedg

Methods of quantifying a n2-carboxyethyl-2′-deoxyguanosine (cedg) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring cedg levels before and after treatment.

Online monitoring of fuel cell reactions by desorption electrospray mass spectrometry

A mass spectrometry-based method of directly online detecting fuel cell reaction products includes passing a reactant sample (16) through a fuel cell (12) to form reaction products that exit the fuel cell (12) in an output stream (26). The method also includes adding a derivatizing reagent (32) to the output stream (28) to form a derivatized output stream (34), wherein the derivatizing reagent (32) reacts with a potential reaction product to thereby form a derivatized reaction product if the potential reaction product is present.

Apparatus and sub-micrometer elemental image analysis by mass spectrometry

A mass spectrometer system for elemental analysis of a planar sample is provided. In some embodiments, the mass spectrometer system comprises: a primary ion source capable of irradiating a segment on planar sample with a beam of primary ions that is less than 1 mm in diameter, c) an orthogonal ion mass-to-charge ratio analyzer positioned downstream of sample interface, the analyzer being configured to separate secondary elemental atomic ions according to their mass-to-charge ratio by time of flight; d) an ion detector for detecting the secondary elemental atomic ions and producing mass spectra measurements; and e) a synchronizer, wherein the system is configured so that so that the beam of primary ions scans across the planar sample in two dimensions and the synchronizer associates the mass spectra measurements with positions on the planar sample..

Laser desorption ionization mass spectrometry using a particulate separation bed

A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (maldi) for use with a mass spectrometer.
Purdue Research Foundation

Ion guide for mass spectrometry

An ion guide is provided having an enclosure extending longitudinally around a central axis from a proximal inlet end to a distal outlet end. The proximal inlet end receives a plurality of ions entrained in a gas flow through an inlet orifice.
Dh Technologies Development Pte. Ltd.

Mass spectroscope and mass spectrometry

According to an embodiment, a mass spectroscope has a chamber, a charged particle beam source, a laser beam source, a mass spectrograph, and an optical system. The chamber accommodates a sample.
Kabushiki Kaisha Toshiba

Parallel mass analysis

A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device.
Thermo Fisher Scientific (bremen) Gmbh

Methods and increased ion throughput in tandem mass spectrometers

In a tandem mass spectrometry system, a first mass analyzer filters parent ions using a wide mass passband with a narrow rejection notch defined according to a modulation format. A wide mass range of parent ions is transmitted to an ion fragmentation device.
Agilent Technologies, Inc.



Mass Spectrometry topics:
  • Mass Spectrometry
  • Spectrometry
  • Spectrometer
  • Mass Spectrometer
  • Chromatograph
  • Extrapolate
  • Hydrocarbon
  • High Resolution
  • Chromatography
  • Quantitative
  • Drug Resistance
  • Phosphorylation
  • Peptide Sequence
  • Formaldehyde
  • Amino Acid


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