|| List of recent Mass Spectrometry-related patents
|Chromatograph mass spectrometry data processing apparatus|
Even when only mass spectra wherein the reproducibility of peak intensities is low are obtained in a mass spectrometry apparatus using, for example, a maldi ion source, the correction of shifts in retention time using tics for a plurality of specimens is performed with good precision. For each mass spectrum, variable scaling is executed which combines such first scaling as to equalize the extent of variations in signal intensity values in one mass spectrum, among different mass spectra, and second scaling for performing weighting according to relative variations in signal intensity values for each mass spectrum (s3).
|Multiplexed detection with isotope-coded reporters|
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (lc ms/ms). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag.
|Apparatus for improved immunosuppressant drug monitoring|
A liquid chromatography/mass spectrometry system includes: a source of a first mobile phase solvent consisting essentially of water plus 10 mm ammonium formate plus 0.05% formic acid; a source of a second mobile phase solvent consisting essentially of methanol plus 10 mm ammonium formate plus 0.05% formic acid; a chromatography column comprising a length of 30 mm or less of a stationary phase comprising an 8-carbon alkyl chain material bonded to 2.6 μm diameter particles having solid silica cores surrounded by porous silica outer layers; an electrospray ion source of a mass spectrometer fluidically coupled to the chromatography column so as to generate ions therefrom; a mass analyzer of the mass spectrometer operable to quantitatively detect the ions; and a programmable processor electronically coupled to the mass analyzer and comprising instructions operable to determine, based on the ion detection, a concentration of everolimus, sirolimus, tacrolimus, or cyclosporin a.. .
|Apparatus for elemental analysis of particles by mass spectrometry|
A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
|Computer-assisted structure identification|
The invention relates to a method for analysing mass spectral data obtained from a sample in gc×gc (2-dimensional) mass spectrometry, comprising: (a) comparing mass spectral data of an analyte with mass spectral data of candidate compounds of known structure in a data library; (b) identifying a plurality of candidate compounds from the library based on similarities of mass spectral data; (c) predicting, for each candidate compound, a value of at least one analytical property using a quantitative model based on a plurality of molecular descriptors; and (d) calculating a match score for each candidate compound based on the value predicted in step (c) and a measured value of the analytical property for the analyte.. .
|Nonaqueous electrolyte air battery|
A nonaqueous electrolyte air battery has a positive electrode comprises at least a catalyst which activates oxygen, a conductive material and a binder, when a thermal decomposition starting temperature of the binder is t1° c. And a thermal decomposition ending temperature of the binder is t2° c.
|Nonaqueous electrolyte air battery|
A nonaqueous electrolyte air battery has s positive electrode comprises at least a catalyst which activates oxygen, a conductive material and a binder, when a thermal decomposition starting temperature of the binder is t1° c. And a thermal decomposition ending temperature of the binder is t2° c.
|Adaptive and targeted control of ion populations to improve the effective dynamic range of mass analyser|
A method of mass spectrometry is disclosed wherein one or more relatively abundant or intense species of ions in a first population of ions are selectively attenuated so as to form a second population of ions. The total ion current of the second population of ions is then adjusted so that the ion current corresponding to ions which are onwardly transmitted to a mass analyser comprising an ion detector is within the dynamic range of the ion detector..
|Methods for detecting vitamin c by mass spectrometry|
Provided are methods for determining the amount of vitamin c in a sample using mass spectrometry. The methods generally involve ionizing vitamin c in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin c in the sample..
|Photo-dissociation of proteins and peptides in a mass spectrometer|
A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2d or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected.
|Cell identification device and program|
An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined.
|Isotopic labeling for the measurement of global protein levels and turnover in vivo|
An entire complement or plurality of isotopically labeled amino acids are introduced into the diet of a test subject. Sufficient amounts of the isotopically labeled amino acids are provided to the subject in order to ensure that the subject incorporates a large percentage of isotopically labeled amino acids into newly synthesized proteins.
|Laser ablation cell|
A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel.
|Mass spectrometers comprising accelerator devices|
A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
|Biomarker for ovarian cancer ctap3-related proteins|
The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer.
|Methods for making microarrays and their uses|
The present invention provides microarrays that can be analysed by more than one technique using a non-covalent ligand attachment strategy to solid supports such as indium tin oxide (ito) covered transparent glass slides. This provides, inter alia, glycan arrays on a micrometer scale which allow multimodal readout by maldi-tof-ms, fluorescence and optical microscopy.
|Chemical identification using a chromatography retention index|
Provided herein is technology relating to identifying unknown compounds and particularly, but not exclusively, to methods and systems for identifying unknown compounds by gas chromatography-mass spectrometry by use of retention index as a second dimension for identification.. .
|Method for determining derivatized analytes in a separated biological fluid|
The present invention comprises methods for determining the presence, amount, or concentration of analytes of interest including vitamin d and other secosteroids from biological samples, through derivatization, with improved speed and ease of analysis and improved sensitivity to mass spectrometry. In a preferred embodiment, the present invention comprises methods for determining the presence, amount, or concentration of analytes of interest, including vitamin d and other secosteroids from whole human blood, through derivatization, and using a plasma collection device to facilitate collection, separation, and preparation of the sample for derivatization and analysis..
|Ion mobility mass spectrometry tags for quantitative applications and methods thereof|
Compound tags and shifting agents are provided that find use in ion mobility spectrometry (ims), mass spectrometry (ms), or a combination of ims and ms, and which can substantially increase separation of multiple components in complex samples and facilitate quantitative and multiplexed analyses. In some cases, the compounds include a linker and a normalizing group, each including a structural unit and separated by a cleaveable group, and a crown ether.
|Method of detecting mycobacterium tuberculosis complex by cell filtrate protein 10-loaded detonation nanodiamond|
A method of detecting mycobacterium tuberculosis complex (mtbc) in a culture media is provided, in which, the culture media containing the mtbc and a biomarker, such as cfp-10, secreted from the mtbc is provided, the culture media is filtered to obtain a filtrate, detonation nanodiamond particles are mixed with the filtrate to form biomarker-loaded detonation nanodiamond particles, and a mass spectrometry analysis process is performed on the biomarker-loaded detonation nanodiamond particles for detecting the biomarker.. .
|Portable field 3he/4he stable isotope detector for use in survey work and autonomous monitoring|
An instrument is described for measurements of the isotopic abundance of 3he and 4he stable isotopes remotely and in near real time. It is designed to work autonomously in the field in harsh environments, and is composed of modestly priced materials, vacuum and electronic subsystems for economical use as a stand-alone instrument.
|Orthogonal acceleration tof with ion guide mode|
Mass spectrometry systems include an electronic controller and a time-of-flight mass analyzer in communication with the electronic controller. The time-of-flight mass analyzer includes a pulsing region defining a channel that extends along an axis.
|Systems and methods for analyzing a sample using a mass spectrometry probe configured to contact the sample|
The invention generally relates to systems and methods for analyzing a sample using a mass spectrometry probe having a tip that is configured to contact a sample and retain a portion of the sample once the probe has been removed from the sample.. .
|Method and apparatus for control of a plasma for spectrometry|
A method of and apparatus for controlling the temperature of an inductively coupled or microwave induced plasma for optical emission spectrometry or mass spectrometry in which the intensities of two spectral lines of radiation emitted by the plasma are measured, and the power provided to sustain the plasma is adjusted so that the ratio of the intensities remains substantially constant.. .
|Microscale mass spectrometry systems, devices and related methods|
Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly.
|Method of processing image charge/current signals|
A method of processing an image charge/current signal representative of trapped ions undergoing oscillatory motion. The method includes applying a validity test to each of a plurality of peaks in the image charge/current signal in the frequency domain, wherein applying the validity test to a peak in the image charge/current signal in the frequency domain includes determining whether a phase angle associated with the peak meets a predetermined condition.
|Integrated magnetron plasma torch, and related methods|
A plasma source for generating microwave-induced plasma includes a plasma torch integrated with a microwave energy source. The torch establishes a gas flow path from one side of the plasma source to the other side.
|Use of detection techniques for contaminant and corrosion control in industrial processes|
Industrial fluids may be monitored at the site of each industrial fluid by introducing a sample of the industrial fluid into a device employing a detection technique for detecting at least one composition within the sample. The detection technique may be or include surface enhanced raman scattering (sers), mass spectrometry (ms), nuclear magnetic resonance (nmr), ultraviolet light (uv) spectroscopy, uv spectrophotometry, indirect uv spectroscopy, contactless conductivity, laser induced fluorescence, and combinations thereof.
|Preparation enhancements and methods of use for maldi mass spectrometry|
Provided herein are compositions and methods useful for preparing and analyzing a sample on a substrate by matrix assisted laser desorption ionization (maldi) mass spectrometry (ms). In some embodiments, compositions provided herein comprise a substrate, matrix and nanoparticles, and sometimes comprise one or more additives and sometimes an analyte.
|Mass spectrometry (ms) identification algorithm|
A system includes a gas chromatograph configured to determine experimental chromatographic data including retention times associated with samples. The system also includes a mass spectrometer configured to determine experimental mass spectral data associated with samples.
|Method for fabricating stable-isotope-labeled target peptide fragment in mass spectrometry|
An object of the present invention is to provide a method for producing a stable isotope-labeled target peptide fragment in mass spectrometry, which achieves inexpensive and convenient production. As a solution to attain the object, the stable isotope-labeled target peptide fragment in mass spectrometry is produced using a method comprising the steps of: expressing a dna conjugate in a system having a stable isotope-labeled amino acid to thereby prepare a stable isotope-labeled protein, wherein the dna conjugate comprises: a tandemly linked dna in which two or more dnas encoding one or more types of target peptide fragments are linked in tandem; and a dna encoding a peptide fragment for concentration measurement; subjecting the stable isotope-labeled protein to fragmentation treatment with trypsin to prepare a stable isotope-labeled peptide fragment for concentration measurement and stable isotope-labeled target peptide fragments; quantifying the stable isotope-labeled peptide fragment for concentration measurement using a liquid chromatograph-tandem mass spectrometer (lc/ms/ms); and calculating the concentration of the stable isotope-labeled target peptide fragment of each type from the quantification value of the stable isotope-labeled peptide fragment for concentration measurement..
|Analytical method of post-translational modifications in hemoglobin|
An analytical method of post-translational modifications in hemoglobin is disclosed. The analytical method comprises the steps of providing a blood comprising the hemoglobin with post-translational modification of nitration, nitrosylation, or oxidation; performing an extraction process to the blood by an organic solvent; quantifying the hemoglobin by a fluorescent spectrometry; hydrolyzing the hemoglobin into a plurality of peptides by an enzyme; and using a nanoflow liquid chromatography-nano spray ionization tandem mass spectrometry to characterize and quantify the post-translational modifications of the hemoglobin..
Methods and materials relate to degradable detergents. The degradable detergents have degradable linkages that are cleaved when subjected to elevated temperature and/or reduced pressure.
|Automatic gain control with defocusing lens|
A method and apparatus for performing mass spectrometry using an electron source, an ion trap, and a voltage-controlled lens located between the electron source and the ion trap. A controller applies a voltage to the lens.
|General mass spectrometry assay using continuously eluting co-fractionating reporters of mass spectrometry detection efficiency|
The invention provides general methods for quantifying any conceivable compound including small organic molecules and biological molecules in mass spectrometric measurements. The methods include the use of chemical or biological reporters such as artificial polypeptides containing proteolytic cleavage sites, which provide proteolytic reporter peptides for standardization of mass spectrometric detection efficiency.
|Methods and apparatus for decomposing tandem mass spectra generated by all-ions fragmentation|
A method for tandem mass spectrometry of a plurality of eluting compounds comprises: (a) performing, during a time period, the steps of: ionizing the plurality of eluting compounds to generate a plurality of precursor ion species; introducing the plurality of precursor ions into a fragmentation cell operated at constant fragmentation energy so as to generate a plurality of product-ion species from at least a portion of the precursor ion species; and generating a mass spectrum of the plurality of product-ion species; and (b) recognizing matches between certain of the product ion species generated during the time period based on correlations between elution profiles of the product ion species.. .
|Method and system for mass spectrometry data analysis|
In estimating a structural formula of an unknown substance produced through partial structural change of an original substance having a known structure caused by metabolism or the like, structural change is considered in two stages, the elimination of a partial structure and the addition of another partial structure. First, an additional partial structure is collected as known information in addition to an msn spectrum of the unknown substance and a structural formula of the original substance.
|Method for evaluating human blastocyst by norepinephrine level in blastocyst culture solution|
The invention provides a new method for evaluating transfer embryos including blastocysts used for in vitro fertilization in fertility treatment, and a method for evaluating transfer embryos using a new biomarker necessary for evaluation. The method comprises the steps of (a) providing a test object, for example, a culture solution of a human blastocyst, containing norepinephrine (noradrenaline) released from a transfer embryo, such as a human blastocyst, obtained from a subject; (b) quantitatively analyzing norepinephrine in the test object by a combination of ultra high performance liquid chromatography and mass spectrometry or the like; (c) predicting the quality of the transfer embryo based on the amount of norepinephrine from analysis results obtained; and (d) transferring the embryo into a suitable female recipient for implantation, if the transfer embryo is predicted to be of good quality and/or to lead to the establishment of a viable pregnancy based on step (c)..
|Nanostructure-initiator mass spectrometry biometrics|
Several embodiments described herein are drawn to methods of identifying an analyte on a subject's skin, methods of generating a fingerprint, methods of determining a physiological change in a subject, methods of diagnosing health status of a subject, and assay systems for detecting an analyte and generating a fingerprint, by nanostructure-initiator mass spectrometry (nims).. .
|Multi-pole ion trap for mass spectrometry|
An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface.
|Mass analysis using alternating fragmentation modes|
A method of mass spectrometry is disclosed wherein a surface induced dissociation fragmentation device is repeatedly switched between a high fragmentation mode and a low fragmentation mode. Parent ions from a first sample are passed through the device and parent ion mass spectra and fragmentation ion mass spectra are obtained.
|Shape analysis and mass spectrometry of individual molecules by nanomechanical systems|
The spatial distribution of mass within an individual analyte can be imaged—in real time and with molecular-scale resolution—when it adsorbs onto a nanomechanical resonator. Each single-molecule adsorption event induces discrete, time-correlated perturbations to the modal frequencies of the device.
|Vitamin b2 detection by mass spectrometry|
Methods are described for measuring the amount of a vitamin b2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin b2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques..
In order to solve a problem in a mass spectrometry that a distribution of an emitted ion and a substance distribution on the measurement object surface are different from each other, which is due to a shaded portion of a irregular surface which falls under a shadow of primary beam, a primary ion optical system of the present apparatus includes a deflection unit configured to deflect the primary ion in such a manner that the primary ion intersects a flight space of the secondary ion in the course of flight.. .
|Method and apparatus for mass spectrometry|
A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (mr tof) mass spectrometry..
|Tandem mass spectrometer and mass spectrometric method|
An ion trap is provided between a collision cell and a time-of-flight mass separator. During a time period in which precursor ions derived from the same compound are selected with a quadrupole mass filter, a collision energy is changed from one to another.
|Detection of membrane protein-therapeutic agent complexes by mass spectrometry|
According to the present invention, there is provided a method of detecting a complex comprising a membrane protein bound to a therapeutic agent by mass spectrometry. The method comprises: (a) providing a solution comprising a detergent micelle in which said complex is contained; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the complex is released from the micelle; (d) ionising the complex; (e) resolving the ionised complex using the mass analyser; and (f) detecting the resolved complex using the detector.
|Methods and systems for experimental set-up and data analysis in targeted proteomics applications|
The invention relates to the analysis of compounds with mass spectrometry and more particularly to instruments, substances, and methods for polypeptide analysis, in particular in targeted proteomics applications and based on indexed retention time as peptide specific property. The method of chemical analysis comprises the steps of: a) providing a first complex sample comprising a set of at least two reference peptides associated to an indexed retention time scale (irt), as well as at least one further peptide; b) performing lc-ms on said complex sample and determining the empirical retention time values (rte) of the reference peptides and of the at least one further peptide; c) translating the empirical retention time values (rte) of the reference peptides and of the at least one further peptide into the indexed retention time scale and associating to each reference peptide a reference indexed retention time value (irtr) and to the at least one further peptide an associated indexed retention time value (irta); d) providing a second complex sample comprising at least one polypeptide as well as said set of the at least two reference peptides; e) performing lc-ms on said second complex sample and determining the empirical retention time values (rte) of the reference peptides; f) translating the empirical retention time values (rte) of the reference peptides into the indexed retention time scale by numerically adapting the transformation function for the conversion of the retention time values (rte) into indexed retention time values such that the calculated indexed retention time values (irte) calculated based on the measured retention time values (rte) of the reference peptides match the assigned indexed retention time values (irtr) of the reference peptides; g) determining the predicted empirical retention time value (rtp) of the at least one further peptide by using the numerically adapted transformation function determined in step f)..
|Global proteomic screening of random bead arrays using mass spectrometry imaging|
Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate.
|Detection and quantification of biomolecules using mass spectrometry|
The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry.
|Methods for detecting dihydroxyvitamin d metabolites by mass spectrometry|
Provided are methods of detecting the presence or amount of a dihydroxyvitamin d metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin d metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin d metabolite in the sample.
|Methods of detection of cancer using peptide profiles|
The disclosed methods address the identification and monitoring of cancer in a subject using serum peptide profiles. Such profiles allow the detection of the differential presence of certain serum peptide markers in comparison with controls.
|Generation of model of composition of petroleum by high resolution mass spectrometry and associated analytics|
A method to determine the model-of-composition of a vacuum resid in which the resid is separated into fractions including the dao fraction which is then separated into chemical classes including saturates, aromatics, sulfides and polars by a combination of soft ionization methods. The results of the ionization analyses are reconciled with other analyses such as bulk analysis, then consolidated to generate the modeol-of composition..
|Quality control reagents and methods|
The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (ms) and/or liquid chromatography (lc) functionalities..
|Methods for rapid identification and quantitation of nucleic acid variants|
There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products..
|Mass distribution spectrometry method and mass distribution spectrometer|
The present invention provides a mass distribution spectrometry which reduces an influence of the dispersion in the times at which ionizing beams irradiate a sample, on a mass spectrometry result, and can measure the mass distribution with high reliability. The mass distribution spectrometry is a mass spectrometry which includes irradiating the sample with a primary ion beam and detecting generated secondary ions, wherein this primary ion beam has a spread toward a direction perpendicular to a travelling direction, has a path length of each primary ion contained in the primary ion beam between a primary ion source and a surface of the sample adjusted by deflecting a trajectory, and is obliquely incident on the surface of the sample..
|Mass spectrometric determination of fatty acids|
The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry..
|Method of operating a mass filter in mass spectrometry|
Disclosed herein is a mass spectrometry method having steps of: transmitting ions from an ion source through a mass filter; processing ions received from the mass filter in a discontinuous ion optical device downstream of the mass filter; operating the mass filter for a plurality of periods in a mass/charge ratio (m/z) filtering mode to transmit ions in one or more selected ranges of m/z to the discontinuous ion optical device; and operating the mass filter in a broad mass range mode transmitting ions of a mass range substantially wider than any mass range transmitted in the m/z filtering mode during one or more periods in which the discontinuous ion optical device is not processing ions from the mass filter. Utilization of this method assists to reduce contamination in the mass filter..
|Photo-dissociation of proteins and peptides in a mass spectrometer|
A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.. .
|Mass spectrometer and mass spectrometric method|
A mass spectrometry using helium as cooling gas is performed to obtain a first mass spectrum (s1), and another mass spectrometry using argon, which is heavier than helium, as cooling gas is performed to obtain a second mass spectrum for the same sample (s2). Due to the difference between the two gases in terms of the effect of promoting dissociation of modifications, an ion peak originating from a target compound from which all the modifications have been dissociated will appear with a higher intensity on the second mass spectrum.
The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (ms)n devices.. .
|Use of probes for mass spectrometric identification and resistance determination of microorganisms or cells|
This invention pertains to identifying one or more hybridization probes sequestered within (or optionally released from the intact) cells or microorganisms by mass spectrometry to thereby determine a trait of the cells or microorganisms and/or to identify the cells or microorganisms themselves. The cells or microorganisms can come from a subject and the information obtained from the mass spectrometry analysis may, if clinically relevant, optionally be used to diagnose and/or treat the subject..
|Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers|
Mass spectrometry cells include one or more interleaved magnetostatic and electrostatic lenses. In some examples, the electrostatic lenses are based on electrical potentials applied to magnetostatic lens pole pieces.
|Mass spectrometry device|
Vacuum gauges are arranged in intermediate vacuum chamber and analytical chamber 10 in which collision cell is installed, and gas pressure determination unit determines whether or not the gas pressures detected by vacuum gauges are at or below a threshold value prior to analysis, and issues an alert if they are at or below the threshold value. If the supply of cid gas into collision cell stagnates, the quantity of cid gas flowing out into the analytical chamber will decrease, and the degree of vacuum in the analytical chamber will thus become too high.
|Sequential low/high-resolution library search|
Provided herein are systems and method for using unit mass library searches for sample identification in accurate mass spectrometry. In general, the systems and methods described herein: (a) obtain an accurate mass spectrum of a sample; (b) calculate a unit mass spectrum based on the accurate mass spectrum; and (c) conduct a unit mass library search, based on the calculated unit masses, to obtain at least one candidate species to thereby identify the sample.