Follow us on Twitter
twitter icon@FreshPatents


Mass Spectrometry patents

      

This page is updated frequently with new Mass Spectrometry-related patent applications.




 Electrostatic mass spectrometer with encoded frequent pulses patent thumbnailElectrostatic mass spectrometer with encoded frequent pulses
A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
Leco Corporation


 Analytical apparatus utilizing electron impact ionization patent thumbnailAnalytical apparatus utilizing electron impact ionization
An analytical apparatus for mass spectrometry comprises an electron impact ionizer including an electron emitter and an ionization target zone. The target zone is arranged to be populated with matter to be ionized for analysis.
Markes International Limited


 Coupling device for mass spectrometry apparatus patent thumbnailCoupling device for mass spectrometry apparatus
An object of the present invention is to provide a technology that enables highly sensitive atmospheric-pressure real-time mass spectrometry of a volatile substance. The present invention provides a coupling device for a mass spectrometry apparatus that is an interface member to be connected to an atmospheric-pressure real-time mass spectrometry apparatus, the coupling device including (a) an excitation gas introducing port, a sample gas introducing port, and an ionized sample gas discharging port, (b) a channel through which the excitation gas introducing port and the ionized sample gas discharging port are in communication, and (c) a space for mixing excitation gas and sample gas being formed in a region of a portion of the channel recited in (b), by the coupling device having a structure in which the sample gas introducing port and the channel recited in (b) are in communication..
Biochromato, Inc.


 Tandem mass spectrometry data processing system patent thumbnailTandem mass spectrometry data processing system
A composition formula of each precursor ion located on a measured mass spectrum is estimated from the m/z value of the precursor ion (s11). A composition formula of each product ion located on a measured ms/ms spectrum is estimated from the m/z value of the product ion (s11).
Shimadzu Corporation


 Tandem mass spectrometry data processing system patent thumbnailTandem mass spectrometry data processing system
Peak information is collected from an ms/ms spectrum in which the product ions generated from ions originating from a plurality of compounds are mixed. Using one of the m/z values of a plurality of ion species as precursor-ion information and the peak information of the ms/ms spectrum as product-ion information, a database search is performed to find candidate compounds for each compound, and a standard ms/ms spectrum of each candidate compound is obtained.
Shimadzu Corporation


 Setting ion detector gain using ion area patent thumbnailSetting ion detector gain using ion area
A control system and method of determining a signal to noise (s/n) ratio of an ion detector system, including an ion detector, electron multiplier or photomultiplier, operates by determining an area of a noise peak, determining an area of a signal peak and determining a ratio of the area of the signal peak to the area of the noise peak. Based thereon, the signal to noise ratio can be optimised.
Micromass Uk Limited


 Methods and materials for monitoring myeloma using quantitative mass spectrometry patent thumbnailMethods and materials for monitoring myeloma using quantitative mass spectrometry
The subject invention concerns methods and materials for diagnosing, monitoring the progress, and/or providing a prognosis for multiple myeloma and other conditions associated with antibody production in a person or animal. The methods of the invention utilize mass spectrometry for quantitative monitoring and detection of antibody produced by the plasma cells.
H. Lee Moffitt Cancer Center And Research Institute, Inc.


 Srm/mrm assay for the cyclin-dependent kinase inhibitor 2a (p16) protein patent thumbnailSrm/mrm assay for the cyclin-dependent kinase inhibitor 2a (p16) protein
Methods are provided for quantifying the cyclin-dependent kinase inhibitor 2a protein (p16) p16 protein directly in biological samples that have been fixed in formalin by srm/mrm mass spectrometry. A protein sample is prepared from the biological sample using, for example, the liquid tissue reagents and protocol and the p16 protein is quantitated in the resulting sample by quantitating in the protein sample at least one fragment peptide from p16.
Expression Pathology, Inc.


 System and  analyzing tissue intra-operatively using mass spectrometry patent thumbnailSystem and analyzing tissue intra-operatively using mass spectrometry
A system and method for ample analysis including acquiring a tissue sample, preparing the tissue sample for mass spectrometry imaging, conducting a mass spectrometry procedure on the tissue sample to produce an image, analyzing the image to determine the presence or absence of a biomarker; and generating a report indicating a presence or absence of cancer.. .
Brigham And Women's Hospital, Inc.


 A single reactor for simplified sample preparation workflows patent thumbnailA single reactor for simplified sample preparation workflows
This disclosure provides a single reactor that accommodates an affinity selector to separate analytes of interest, and an enzyme reactor that digest the analyte to suitable peptides for mass spectrometry. The single reactor formats described herein accommodate workflows wherein separation precedes digestion as well as workflows wherein digestion precedes separation selection..
Perfinity Biosciences, Inc.


Multiplexed electrostatic linear ion trap

Systems and methods are provided for performing multiplex electrostatic linear ion trap mass spectrometry. A first beam of ions is received and the first beam is split into n beams of ions using a beam splitter.
Dh Technologies Development Ptd. Ltd.

Ion guide for mass spectrometry

Methods and systems for transmitting ions in an ion guide are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can cause at least a portion of ions entrained in a gas flow entering an ion guide to be extracted from the gas jet and be guided downstream along one or more path of gas flow, where the gas lacking the ions can be removed from the ion guide.
Dh Technologies Development Pte. Ltd.

Srm/mrm assay for the fibroblast growth factor receptor 2 (fgfr2) protein

Methods are provided for quantifying the fibroblast growth factor receptor 2 protein (fgfr2) directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm)/multiple reaction monitoring (mrm) mass spectrometry. The biological sample may be selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells.
Expression Pathology, Inc.

Srm/mrm assay for the mesothelin (msln) protein

Methods are provided for detecting and quantifying the mesothelin protein (msln) in biological samples that have been fixed in formalin using selected reaction monitoring (srm)/multiple reaction monitoring (mrm) mass spectrometry. The biological sample may be, for example, tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.

Formalin-fixed isotope-labeled reference standards and methods for fabrication and use thereof

One or more cells are labeled with minor stable isotopes, characterized, and preserved for subsequent use as a bio-specimen reference standard. The one or more cells are grown in culture media supplied with minor stable isotopes in concentrations substantially different from normally occurring concentrations, thereby supplanting major stable isotopes that would normally be incorporated into the proteins of the cells.
Bioproximity, Llc

Srm/mrm assay for the 6-o-methylguanine-dna methyltransferase (mgmt) protein

The current disclosure provides methods for detecting and quantitating the 6-o-methylguanine-dna methyltransferase protein (mgmt) directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed with formaldehyde containing agents/fixatives and may include formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and/or paraffin embedded.
Expression Pathology, Inc.

Mass spectrometer and mass spectrometry method

A mass spectrometer including an ionization source including an esi probe (201), an esi power source (24), a corona needle (202) and an apci power source (24); an ionization condition storage section (41) for storing a plurality of ionization conditions related to the liquid sample, set by an analysis operator, with the ionization conditions differing from each other in the value of the esi voltage or/and the value of the apci voltage; a mass spectrometry executer (43) for conducting a mass spectrometry for an ion generated from the liquid sample using each of the plurality of ionization conditions; and a mass spectrometry result selector (44) for selecting, for each of the one or plurality of components, a mass spectrometry result in which the ion is detected with a suitable level of intensity for an analysis, from the mass spectrometry results respectively obtained for the plurality of ionization conditions.. .
Shimadzu Corporation

Preparation enhancements and methods of use for maldi mass spectrometry

Provided herein are compositions and methods useful for preparing and analyzing a sample on a substrate by matrix assisted laser desorption ionization (maldi) mass spectrometry (ms). In some embodiments, compositions provided herein comprise a substrate, matrix and nanoparticles, and sometimes comprise one or more additives and sometimes an analyte.
Agena Bioscience, Inc.

Method and contained-electrospray for use in mass spectrometry and droplet reactions

Provided herein are apparatuses that can comprise an electrospray emitter comprising a sample capillary extending from a sample inlet to a sample outlet and an element comprising a conduit coaxially disposed around the electrospray emitter thereby forming a chamber extending between the conduit and the sample capillary and terminating in a gas outlet. The element can further comprise, in some examples, a carrier gas inlet fluidly connected to the chamber, and a working gas inlet fluidly connected to the chamber, wherein the chamber is configured to provide a path for fluid flow from the carrier gas inlet and the working gas inlet to the gas outlet.
Ohio State Innovation Foundation

Liquid chromatography-mass spectrometry device

This invention improves the sensitivity of a liquid chromatography-mass spectrometry device by reducing the number of neutral particles that are not ionized during ionization and the number of low-molecular ions from a solvent used in the liquid chromatography. Said liquid chromatography-mass spectrometry device is provided with ion sources, a mass spectrometry unit, a detector, and three electrodes laid out so as to be parallel to each other.
Hitachi Hich-technologies Corporation

Multi stage scroll vacuum pumps and related scroll devices

A multi-stage vacuum pump, expander, or compressor, that incorporates one or more stages of a fixed scroll(s) and orbiting scroll(s) that operates simultaneously. The motor drives the orbiting scroll(s) within the structure, and the various fixed and orbiting scrolls are arranged for either parallel generation of a vacuum or high pressure gas, or arranged in series for generating of a significantly high vacuum or gaseous pressure, or a combination of parallel arranged and series arranged fixed and orbiting scrolls may be embodied within the structure, operated by a single motor means, in order to attain the high efficiencies of operation as a vacuum pump, or a gaseous compressor, during its functioning.

Circuit for generating a voltage waveform

A circuit for generating a voltage waveform at an output node. The circuit includes a voltage rail connected to the output node via a voltage rail switch; an anchor node connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes two or more transistors connected in series; and a control unit configured to change the voltage at the output node by controlling the voltage rail switch and the bidirectional switch so that, if a load capacitance is connected to the output node, a resonant circuit is established between the inductor and the load capacitance.
Shimadzu Corporation

Globally optimized targeted mass spectrometry (got-ms)

Globally optimized targeted (got)-ms, combines many of the advantages of targeted detection and global profiling in metabolomics analysis, including the capability to detect unknowns, broad metabolite coverage, and excellent quantitation. A global search of precursor and product ions using a single triple quadrupole (qqq) mass spectrometer includes sim incremental scanning or incremental ms scanning performed in the mass range of 40-2000 da, followed by tandem ms/ms scanning with incremental collision energy for precursor ions to profile product ions..
University Of Washington

Srm/mrm assay for subtyping lung histology

The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins that are particularly advantageous for quantifying the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.

Method and predicting effective dose or sensitivity of 5-hydroxy-1h-imidazole-4-carboxamide, determining amount of xanthosine monophosphate, and treatment agent and treating myelodysplastic syndrome

An object of the present invention is to provide a method and apparatus for predicting an effective dose of or the sensitivity to 5-hydroxy-1h-imidazole-4-carboxamide, which are capable of performing a determination in a simple operation and a short time, a method for determining amounts of xanthosine monophosphate, and a treatment agent and treatment method for treating myelodysplastic syndrome. According to the present invention, provided are a method for predicting an effective dose of or the sensitivity to 5-hydroxy-1h-imidazole-4-carboxamide, including determining amounts of xanthosine monophosphate in blood and a prediction apparatus, a method for determining amounts of xanthosine monophosphate, including determining xanthosine monophosphate in blood in two different determining conditions by mass spectrometry, and a treatment agent and treatment method for treating myelodysplastic syndrome..
Fujifilm Corporation

Compositions and processes for improved mass spectrometry analysis

The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present in mass spectra.
Agena Bioscience, Inc.

Mass spectrometry probes and systems for ionizing a sample transport

The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate..
Indian Institute Of Technology Madras

Lens pulsing apparatus and method

A lens pulsing apparatus and method for transferring ions in a mass spectrometry system from an area of high pressure to an area of low pressure which includes a gating apparatus that contains multiple electrostatic lenses. Each of the lenses operates at different voltages.
Dh Technologies Development Pte. Ltd

Tandem mass spectrometer and tandem mass spectrometry method

The invention relates to a tandem mass spectrometer comprising an ionization source that can produce ions; a mass analyser comprising an ion trap arranged in such a way as to receive ions from the ion source and a detector that can detect ions leaving the ion trap according to the mass to charge (m/z) ratio thereof; ion activation means for activating ions that can fragment at least some of the ions trapped in the ion trap; and coupling means arranged between the ion trap and said ion activation means. According to the invention, the ion activation means consists of a glow discharge lamp that can generate a light beam oriented towards the ion trap, said light beam being electromagnetic radiation in the vacuum ultraviolet wavelength range with photon energies of between 8 ev and 41 ev in such a way as to fragment at least some of the ions trapped in the ion trap..
Synchrotron Soleil

Mass spectrometer and mass spectrometry method

The degree of ion dissociation which occurs within a first intermediate vacuum chamber (212) maintained at a comparatively low degree of vacuum depends not only on the amount of energy of the ion but also on the size and other properties of the ion. Accordingly, a predetermined optimum level of dc bias voltage is applied to an ion guide (24) so as to create, within the first intermediate vacuum chamber (212), a dc electric field which barely induces the dissociation of an ion originating from a target compound in a sample while promoting the dissociation of an ion originating from a foreign substance which will form a noise signal in the observation of the target compound.
Shimadzu Corporation

Mrm/srm assay for death receptor 5 protein

Selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.

Srm assay for pd-l1

The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the pd-l1 protein that are particularly advantageous for quantifying the pd-l1 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and/or paraffin embedded.
Expression Pathology, Inc.

Method for multiplexed sample analysis by photoionizing secondary sputtered neutrals

Disclosed herein is a method of generating a high resolution image of a cellular sample, the method including i) labeling a cellular sample with at least one mass tag, thereby producing a labeled sample in which a biological feature of interest is associated with the at least one mass tag, ii) scanning the sample with a continuous or near-continuous primary ion beam to generate sputtered secondary ions and sputtered neutral species, iii) photoionizing the sputtered neutrals to generate ionized neutral species, wherein the sputtered neutrals are photoionized at a site that is proximal to their source on the sample, iv) detecting the ionized neutral species by mass spectrometry, thereby obtaining spatially addressed measurements of the abundance of the at least one mass tag across an area of the sample, and v) producing an image of the sample using the measurements. A system for performing the method is also provided..
The Board Of Trustees Of The Leland Stanford Junior University

Systems and methods for improved robustness for quadrupole mass spectrometry

A method for analyzing a sample by mass spectrometry includes producing ions from the sample, delivering the ions to an entrance of a multipole, and applying oscillatory and resolving dc voltages to electrodes of the multipole. The oscillatory and resolving dc voltages cause the multipole to selectively transmit to its distal end ions within a range of mass-to-charge ratios (m/z's) determined by the amplitudes of the oscillatory and resolving dc voltages.
Thermo Finnigan Llc

Neutron encoded mass tags for analyte quantification

The invention provides mass spectrometry methods, compositions and systems which enable a unique platform for analyte quantitation accessing very high degrees of multiplexing and accurate quantification, particularly well-suited for a range of quantitative analysis for proteomics applications. Embodiments of the present methods and systems combine isotopic coding agents characterized by very small differences in molecular mass with mass spectrometry methods providing large resolving power to provide relative or absolute analyte quantification in a large number of samples..
Wisconsin Alumni Research Foundation

Mass determination using ion mobility measurements

A method of mass spectrometry is disclosed comprising: providing an algorithm or relationship that relates the ion mobilities of an analyte ion through three gases of different polarizability to the mass of the analyte ion; measuring the ion mobilities of an analyte ion through first, second and third different drift gases; and using the measured ion mobilities and said algorithm or relationship to determine the mass of the analyte ion. Embodiments of the invention enable the mass of an analyte to be determined without having to know the specific properties of the analyte ion..
Micromass Uk Limited

Rapid test for microbial resistances by mass spectrometry

The invention relates to methods and instruments for determining the resistances of microbes to antibiotics, in particular those microbes which produce beta-lactamases. The method determines the resistance of the microbes in less than an hour by incubating a tiny quantity of the microbes on a mass spectrometric sample support plate after they have been combined with a dosed quantity of a suitable antibiotic, for example the beta-lactam antibiotic imipenem, and by direct mass spectrometric measurement of the breakdown of the antibiotic by the microbial enzymes..
Bruker Daltonik Gmbh

Maldi-tof ms assaying an analyte in a bodily fluid from a subject

A method for assaying an analyte in a bodily fluid from a subject includes collecting a sample of the bodily fluid comprising an analyte of interest from a subject. A sample with the bodily fluid comprising the analyte of interest suitable for analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof) is then prepared.
Virgin Instruments Corporation

Ion transfer tube with intermittent inlet

An ion transfer tube assembly, a mass spectrometry system, and a method for providing an ion stream to an ion detection device are described that include using an ion transfer tube and an additional conduit connected to a small high-flow low vacuum pump and a valve. In an implementation, an ion transfer tube assembly includes an ion transfer tube assembly having an intermittent inlet for delivering an ion stream to an ion detection device that employs example techniques in accordance with the present disclosure includes an ion transfer tube, where the ion transfer tube is coupled to a first conduit; a second conduit coupled to the ion transfer tube and the ion detection device; and a third conduit coupled to the second conduit, where the third conduit includes a valve and is coupled to a pump..
Smiths Detection Inc.

Method of correlating precursor and fragment ions

A method of mass spectrometry is disclosed comprising separating precursor ions using an ion mobility separator such that different precursor ions have different drift times through the on mobility separator; mass filtering said separated precursor ions with a mass filter, wherein the mass to charge ratios of the precursor ions transmitted by the mass filter vary as a function of the drift times of the precursor ions through the ion mobility separator; performing a first mode of operation comprising fragmenting the separated and mass filtered precursor ions in a fragmentation device to form fragment ions; urging the fragment ions through the fragmentation device such that fragment ions derived from different precursor ions that have been separated by the ion mobility separator are maintained spatially separated from each other as they are urged through the fragmentation device; and detecting the fragment ions. The method enables precursor ions to be associated with their related fragment ions more accurately..
Micromass Uk Limited

Mass spectrometry clinical diagnostic applications

A mass spectrometer system for analysis of clinical samples includes a source of clinical samples. A controller receives the clinical samples from the source of clinical samples.
Virgin Instruments Corporation

High-purity aluminium grain material and producing the same

An object of the present invention is to provide an aluminium grain material having significantly high purity, and a method for producing the same. Disclosed is an aluminium grain material having an average mass per grain of 0.01 to 10 g, wherein the total content of twelve elements of silicon (si), iron (fe), copper (cu), magnesium (mg), titanium (ti), vanadium (v), chromium (cr), manganese (mn), nickel (ni), zinc (zn), gallium (ga), and zirconium (zr) in the aluminium grain material, measured by glow discharge mass spectrometry, is 5 ppm by mass or less..
Sumitomo Chemical Company, Limited

Mitochondria-targeted dicarbonyl sequestering compounds

The invention relates to compounds having formula (1): a-l-b or pharmaceutically acceptable salts thereof, wherein: a is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; l is an optional linker moiety; and b is a mitochondrial targeting moiety. The invention also relates to pharmaceutical compositions containing such compounds and salts, and to the use of such compounds and salts for treating diabetes, preferably hyperglycemic diabetes.
Medical Research Council

Energy resolved time-of-flight mass spectrometry

A time-of-flight mass spectrometer (tof-ms) utilizes an ion dispersion device and a position-sensitive ion detector or an energy-sensitive ion detector to enable measurement of time of flight and kinetic energy of ions arriving at the detector. The measurements may be utilized to improve accuracy in calculating ion masses..
Agilent Technologies, Inc.

Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry

A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.. .
Wayne State University

Solid phase extraction, derivatization with crown ethers, and mass spectrometry, methods, reagents and kits

The present disclosure is directed to methods reagents and kits for solid phase extraction, derivatization with crown ether containing derivatizing agents, and mass spectrometry of the derivatized analytes.. .
Quantalytical Labs Inc.

Methods for quantitation of insulin levels by mass spectrometry

Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and c-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
Quest Diagnostics Investments Llc

Single cell analysis using secondary ion mass spectrometry

A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (sims), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed.
The Board Of Trustees Of The Leland Stanford Junior University

Method of ft-ims

A method of fourier transform ion mobility mass spectrometry is disclosed comprising determining the presence of different types of ions by determining that the different types of ions have different combinations of ion mobility and mass to charge ratio.. .
Micromass Uk Limited

Ruggedized advanced identification mass spectrometer

A dual-ionization mass spectrometer includes a first mass spectrometer module forming a hard ionization mass spectrometer, a second mass spectrometer forming a soft ionization mass spectrometer, a vacuum ultraviolet light source positioned between the first and second modules, a housing encompassing the first and second sets of plates and the light source, and an inlet positioned to receive a sample of an analyte and provide it to at least one of the sets of plates. A method of detecting a substance includes receiving a sample of an analyte into a housing through an inlet, performing soft ionization mass spectrometry on the sample with a soft ionization mass spectrometer in the housing, performing hard ionization spectrometry on the sample with a hard ionization spectrometer in the housing if needed, and generating a detection result from at least one of the soft ionization spectrometry and the hard ionization spectrometry..
Sri International

Amino acid sequence analyzing method and system

Peptide-fragment mixtures obtained by fragmenting a sample with each of multiple enzymes which cause cleavage at different sites are subjected to mass spectrometry. De novo sequencing is performed on the obtained results to deduce partial sequence candidates for various kinds of fragments (s1 and s2).
Shimadzu Corporation

Multiplex mrm assay for evaluation of cancer

The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (er), progesterone receptor (pr), and/or antigen ki67 (ki67) proteins that are particularly advantageous for quantifying the er, pr, and/or ki67 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.

Method of isolating ions

A method of mass spectrometry is disclosed comprising isolating a group of different ions derived from chemical compounds in the same class, wherein the different ions have different mass to charge ratios and ion mobilities. The step of isolating comprises temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter.
Micromass Uk Limited

Method of associating precursor and product ions

A method of mass spectrometry is disclosed comprising selecting a modification of interest that may modify the mass to charge ratios of precursor ions of interest when said precursor ions are subjected to a fragmentation or reaction condition for producing product ions. The method then filters the product ions (or product ion data) such that only a subset of the product ions are transmitted and detected (or a subset of the data remains) and so as to exclude product ions (or product ion data) that could not have possibly resulted from the modification of interest.
Micromass Uk Limited

Fuel markers and methods of producing and using same

Wherein x can be carbon (c), oxygen (o), or sulfur (s); r1 and r2 can each independently be hydrogen, a c1 to c20 alkyl group, or a c6 to c10 aryl group; r3 and r3′ can each independently be hydrogen or a c1 to c4 alkyl group; r4 and r4′ can each independently be hydrogen, a c1 to c4 alkyl group, a c4 to c10 cycloalkyl group, or a c6 to c10 aryl group; r5 and r5′ can each independently be a c4 to c10 alkyl group; r6 and r6′ can each independently be hydrogen or a c1 to c6 alkyl group; and r7 and r7′ can each independently be hydrogen or a c1 to c4 alkyl group; and wherein the compound characterized by formula i when subjected to gas chromatography-mass spectrometry (gc-ms) using electron ionization produces at least one ion having a mass-to-charge ratio of greater than about 300 at an ionization energy of equal to or greater than about 70 ev.. .

Microscale mass spectrometry systems, devices and related methods

mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly.
The University Of North Carolina At Chapel Hill

Ion trap mass spectrometers

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region; selecting a target maximum charge desired to be stored within the ion storage region at any given time; and reducing the ion current passing to the ion storage region such that the ions entering the ion storage region do not cause the total charge within the storage region to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region comprises: temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter.
Micromass Uk Limited

Charge-stripping of multiply-charged ions

A method of mass spectrometry or ion mobility spectrometry is disclosed wherein a sample is ionised by an electrified sprayer so as to produce multiply charged analyte ions of a first polarity in gas-phase. A reaction region is provided downstream of the electrified sprayer, wherein the reaction region is maintained substantially at atmospheric pressure and is maintained substantially free of electric-fields.
The University Of British Columbia

Methods for data-dependent mass spectrometry of mixed biomolecular analytes

A method for mass spectral analysis of a sample containing a plurality of biomolecule species comprises: (a) mass analyzing a plurality of first-generation ion species generated from a sample portion; (b) automatically recognizing, for each of at least one biomolecule species, a respective subset of m/z ratios corresponding to respective first-generation ion species generated from the each biomolecule species; (c) selecting, from each recognized subset, a single representative m/z ratio; (d) isolating a sub-population of ions having each representative m/z ratio from ions having other m/z ratios; and (e) fragmenting each isolated sub-population of ions so as to generate second-generation ion species.. .
Thermo Finnigan Llc

Mass spectrometry-based identifying and maintaining quality control factors during the development and manufacture of a biologic

The invention provides methods for determining a set of critical features that serves as a “map” of attributes critical for maintaining the structure and function of a biologic. The map can serve as a development tool, e.g., as a guide or target during the development of expression, purification, and formulation protocols, a quality assurance tool during manufacturing, or as a definitive identifier of the specific biologic.
Bioanalytix, Inc.

Template for epitaxial growth, producing the same, and nitride semiconductor device

The present invention provides a method for producing a template for epitaxial growth, the method including: a surface treatment step of dispersing ga atoms on a surface of a sapphire substrate; and an aln growth step of epitaxially growing an aln layer on the sapphire substrate, wherein in a ga concentration distribution in a depth direction perpendicular to the surface of the sapphire substrate in an internal region of the aln layer excluding a near-surface region up to a depth of 100 nm from the surface of the aln layer, which is obtained by secondary ion mass spectrometry, a position in the depth direction where the ga concentration takes the maximum value is present in a near-interface region located between the interface of the sapphire substrate and a position at 400 nm spaced apart from the interface to the aln layer side, and the maximum value of the ga concentration is 3×1017 atoms/cm3 or more and 2×1020 atoms/cm3 or less.. .
Soko Kagaku Co., Ltd.

Laser enabled imaging mass cytometry

The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (la-icp-ms). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the icp, followed by analysis by mass cytometry..
Fluidigm Canada Inc.

Electrically conductive and filtrating substrates for mass spectrometry

A mass spectrometry substrate includes an electrically conductive material providing an electrical conductivity that allows at least one of a first and a second surface of the substrate to be maintained at a desirable potential for ion extraction while ions are desorbed during ionization. A solid lattice material comprises a plurality of pores positioned in a plurality of layers that form a network of at least one continuous channel extending from a first surface of the substrate to a second surface of the substrate.
Virgin Instruments Corporation

Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers

mass spectrometry cells include one or more interleaved magnetostatic and electrostatic lenses. In some examples, the electrostatic lenses are based on electrical potentials applied to magnetostatic lens pole pieces.
Oregon State University

Methods and systems for measuring serotonin in a sample

Disclosed are methods and systems for measuring serotonin in a sample using liquid chromatography and mass spectrometry.. .
Laboratory Corporation Of America Holdings

Compounds and methods for peg metabolite and peg breakdown product assays

Disclosed herein are compounds and methods for identifying and quantifying a metabolite or breakdown product of peg. A sample may be assayed for peg metabolites or breakdown products using liquid chromatography combined with mass spectrometry.
Colonaryconcepts Llc

Mass spectrometry analysis of microorganisms in samples

The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
Purdue Research Foundation

Ms/ms analysis using ecd or etd fragmentation

A method of mass spectrometry is disclosed comprising: providing supercharged analyte ions; and supplying electrons or reagent ions to said analyte ions so as to transfer charge from said reagent ions or electrons to said analyte ions, said transfer of charge causing at least some of said analyte ions to dissociate. The charge transfer step is performed at a relatively high pressure and preferably substantially at atmospheric pressure..
Micromass Uk Limited

Data dependent ms/ms analysis

A method of mass spectrometry is disclosed comprising comparing mass spectral data so as to identify a precursor ion in the mass spectral data that has a predetermined mass difference to a product ion in the mass spectral data; and determining whether said precursor ion is a precursor ion of interest by comparing the ion signal profile for the precursor ion with the ion signal profile for the product ion. If the profiles match then the precursor ion is determined to be an ion of interest.
Micromass Uk Limited

Cmet protein srm/mrm assay

Specific peptides are provided, and derived ionization characteristics of those peptides, from the hepatocyte growth factor receptor (cmet) protein. The peptides are particularly and surprisingly advantageous for quantifying by the method of selected reaction monitoring (srm) mass spectrometry the cmet protein directly in biological samples that have been fixed in formalin, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry.
Expression Pathology, Inc.

Quaternary amine containing isobaric tag for quantitative glycan profiling

The disclosure provides quaternary amine containing isobaric tag reagents useful in the analysis of biomolecules and methods of making and using the quaternary amine containing isobaric tag reagents. The quaternary amine containing isobaric tag reagents are particularly useful for glycan analysis, especially quantitative glycan profiling such as glycan quantitation by tandem mass spectrometry..
University Of Maryland, College Park

System and high throughput mass spectrometric analysis of proteome samples

Disclosed herein is a system and method for analyzing a specimen containing the proteome by mass spectrometry. The system includes a protein separation module; a matrix processing module; and a mass spectrometer module.
Northwestern University

Enzyme coupled assay for quantification of protein and peptide binding by samdi mass spectrometry

Disclosed herein are methods of using an immobilized substrate, immobilized ligand, and a fusion protein of an enzyme for the substrate and a receptor for the ligand, where the immobilized substrate can react to form an immobilized product that has a different mass than the immobilized substrate, and using this transformation to indirectly determine the binding of the receptor and the ligand. These methods can be used for high-throughput screening for possible modulators (e.g., inhibitors or activators) of the ligand-receptor interaction..
Northwestern University

Mass spectrometry-cleavable cross-linking agents to facilitate structural analysis of proteins and protein complexes, and using same

Where x is an n-hydroxy-succinimidyl or similar heterocyclic group. Also provided is a method of mapping protein-protein interactions of protein complexes using various mass spectrometry techniques..

Dynamic resolution correction of quadrupole mass analyser

A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition.. .
Micromass Uk Limited

Microbial analysis

The present invention is concerned with a method of identifying microbial strains (e.g. From a cell culture), the method comprising; i) a lipid extraction step, comprising extraction of phospholipids from the microbe, suitably with an extraction composition comprising more than 50 vol % meoh; ii) a sample preparation step, comprising preparation of a maldi sample incorporating the extracted lipids; iii) a data gathering step, comprising performing maldi-based mass spectrometry on the maldi sample, and iv) a microbe identification step, comprising analysis of the mass spectrometry data to characterise or identify the microbial strain.
Kratos Analytical Limited

Mass spectrometers comprising accelerator devices

A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
Micromass Uk Limited

Systems and methods for using interleaving window widths in tandem mass spectrometry

Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.

Multidrug analysis in urine by liquid chromatography-tandem mass spectrometry

A fast and reliable method for the determination of multiple drugs and their metabolites belonging to different chemical and toxicological class from a biological sample is provided. The method involves mixing of biological sample with internal standards which does not require sample extraction or derivatization prior to analysis.
Castle Medical, Llc

Use of windowed mass spectrometry data for retention time determination or confirmation

A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans.
Dh Technologies Development Pte. Ltd.

Time-of-flight mass spectrometry using multi-channel detectors

A time-of-flight mass spectrometer (tof-ms) utilizes a multi-channel ion detector to detect ions traveling in separate flight paths, spatially dispersed along a drift axis and/or a transverse axis, in a flight tube of a tof analyzer. The ion beams may be dispersed by drift energy, deflection along the drift and/or transverse axis, ion mass, or a combination of two or more of the foregoing.
Agilent Technologies,inc.

Mass spectrometry data processing apparatus and mass spectrometry data processing method

A mass spectrometry data processing apparatus includes a data analysis unit that processes a mass spectrum of each of analysis-target areas within a two-dimensional range set on a sample. The data analysis unit obtains a plurality of mass spectra each associated with position information of a corresponding one of the analysis-target areas; creates an average mass spectrum that is an average of the plurality of obtained mass spectra; extracts, for each mass range, a highest peak by comparing the plurality of obtained mass spectra with one another, and creates a maximum mass spectrum constituted by the extracted highest peaks; creates an intensity ratio spectrum indicating an intensity ratio of the average mass spectrum to the maximum mass spectrum; and selects a peak in a range of a threshold set for the intensity ratio spectrum and specifies a mass range including the peak..
Jeol Ltd.

Methods and compositions for enzyme linked immuno and hybridization mass spectrometric assay

Disclosed are sensitive methods for detecting a target substance in low concentrations. The method can include immobilizing a target substance to a solid phase; incubating the immobilized target substance with a reporter enzyme detection probe in solution under conditions for forming target: enzyme detection probe complexes; washing the solid phase to remove any unbound reporter enzyme detection probe; incubating the target: enzyme detection probe complex with a reporter enzyme detection probe substrate in substrate reaction solution to generate one or more ionizable products; and detecting one or more of the one or more ionizable products using mass spectrometry (ms)..
Yyz Pharmatech, Inc.

Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugate

Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, and purifications.
Bio-rad Laboratories, Inc.

Time-of-flight mass spectrometer

An embodiment of the invention relates to a tof-ms capable of performing mass spectrometry of a sample at a high throughput. The tof-ms has an acceleration part for accelerating an ion, a detector for detecting an event of arrival of the accelerated ion, and a data processing part for performing mass spectrometry of the sample, based on a time of flight of the ion.
Hamamatsu Photonics K.k.

Multiplexed precursor isolation for mass spectrometry

Systems and methods for multiplexed precursor ion selection are provided. A mass isolator includes a selection region of rods, a transmission region of rods, and a barrier electrode lens separating the selection and transmission regions.
Dh Technologies Development Pte. Ltd.

Multiplexed precursor isolation for mass spectrometry

Systems and methods for identifying precursor ions of product ions from combined product ion spectra are provided. N precursor ions are selected.
Dh Technologies Development Pte. Ltd.

Srm/mrm assay for the fatty acid synthase protein

Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.

Methods for identifying fungi

Methods for identifying fungal species by analysis of fungal membrane lipids, such as glycerophospholipids, sphingolipids and sterols, using mass spectrometry ionization patterns are disclosed.. .
University Of Maryland, Baltimore

Mass spectrometry using laserspray ionization

Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (lsi). Lsi can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 daltons.
Wayne State University

Msia-srm assay for biomarker analysis

The present disclosure provides assays, methods and signature peptides for the identification and quantification of biomarkers in a sample. In particular, the present disclosure relates to the development of mass spectrometric immunoassays with selected reaction monitoring mass spectrometry (msia-srm ms) platforms for biomarker analysis.
Nuclea Biotechnologies, Inc.

Probe displacement measuring apparatus, ionization apparatus including the same, and mass spectrometry apparatus

A probe displacement measuring apparatus includes a cantilever probe, a light irradiation unit configured to irradiate the probe with light, a light receiving element configured to receive reflected light obtained by reflecting light emitted by the light irradiation unit on a surface of the probe as a spot, and a displacement obtaining unit configured to obtain displacement of the probe in accordance with a position of the spot on the light receiving element. The light receiving element has first and second light receiving surfaces divided by a straight division line.
Canon Kabushiki Kaisha

Remote laser ablation electrospray ionization mass spectrometry

In various embodiments, a device may generally comprise a remote ablation chamber comprising an inlet and an outlet, a laser to deposit energy into a sample in the chamber to ablate the sample and generate ablation products in the chamber, a transport device in fluid communication with the outlet, an ionization source to ionize the ablation products to produce ions, and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation products or the ions may be transported in a fluid stream from the ablation chamber through the transport device.
The George Washington University

Mass correction

Disclosed is a method of mass spectrometry comprising the steps of: providing a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components as a function of retention time; chromatographically separating a sample, said sample containing at least some of said matrix components and one or more analyte components; analysing said sample at a plurality of retention times to obtain sample data, said sample data comprising one or more physico-chemical properties of one or more sample components as a function of retention time; and calculating one or more error values as a function of retention time based on a comparison between said sample data and said matrix data.. .
Micromass Uk Limited



Mass Spectrometry topics:
  • Mass Spectrometry
  • Spectrometry
  • Spectrometer
  • Mass Spectrometer
  • Chromatograph
  • Extrapolate
  • Hydrocarbon
  • High Resolution
  • Chromatography
  • Quantitative
  • Drug Resistance
  • Phosphorylation
  • Peptide Sequence
  • Formaldehyde
  • Amino Acid


  • Follow us on Twitter
    twitter icon@FreshPatents

    ###

    This listing is a sample listing of patent applications related to Mass Spectrometry for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mass Spectrometry with additional patents listed. Browse our RSS directory or Search for other possible listings.


    2.2793

    file did exist - 5401

    2 - 1 - 101