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Mass Spectrometry patents



      

This page is updated frequently with new Mass Spectrometry-related patent applications.




Date/App# patent app List of recent Mass Spectrometry-related patents
02/04/16
20160035552 
 Method and system for tandem mass spectrometry patent thumbnailMethod and system for tandem mass spectrometry
A method of data independent ms-ms analysis is disclosed. The method comprises ramping or stepping in small steps of a wide (at least 10 amu) parent mass window in a first parent selecting mass spectrometer (ms1), arranging rapid ion transfer through a collisional cell, either by axial gas flow or by an axial dc field or by a travelling rf wave, frequently pulsing an orthogonal accelerator with a string of time-encoded pulses, analyzing fragment ions in a multi-reflecting time-flight mass spectrometer, acquiring data in a data logging format, and decoding signal strings corresponding to the entire scan of parent masses, such that fragment spectra are formed based on time correlation between fragment and parent masses.
Leco Corporation


02/04/16
20160035551 
 Data dependent control of the intensity of ions separated in multiple dimensions patent thumbnailData dependent control of the intensity of ions separated in multiple dimensions
A method of mass spectrometry is disclosed comprising setting an attenuation factor of an attenuation device to a first value and then separating or filtering ions according to a first physico-chemical property and separating or filtering ions according to a second physico-chemical property and obtaining a multi-dimensional array of data. The most intense ion peak within one or more subsets of the multi-dimensional array of data is determined.
Micromass Uk Limited


02/04/16
20160035550 
 Plasma cleaning for mass spectrometers patent thumbnailPlasma cleaning for mass spectrometers
A mass spectrometry (ms) system may be cleaned by generating plasma and contacting an internal surface of the system to be cleaned with the plasma. The system may be switched between operating in an analytical mode and in a cleaning mode.
Agilent Technologies, Inc.


02/04/16
20160033527 
 System and  determining amino acid sequence of polypeptide patent thumbnailSystem and determining amino acid sequence of polypeptide
This invention discloses systems and methods for determining the sequence of amino acids in a short peptide chain that constructs a protein. The protein is firstly hydrolyzed to various short peptides and amino acid enantiomers.
Chung Yuan Christian University


02/04/16
20160033522 
 Methylcitrate analysis in dried blood spots patent thumbnailMethylcitrate analysis in dried blood spots
There is provided a method of measuring methylcitrate (mca) in a sample by derivatizing the mca, for example with 4-[2-(n,n-dimethylamino)ethylaminosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole (daabd-ae); measuring a level of the derivatized mca; and determining the level of mca from the measured level. The sample may be a dried blood spot (dbs), and the extraction and derivatization may be carried out simultaneously.
Children's Hospital Of Eastern Ontario


02/04/16
20160032273 
 Characterization of mrna molecules patent thumbnailCharacterization of mrna molecules
The present invention describes methods for the characterization of mrna molecules during mrna production. Characterizing mrna includes processes such as oligonucleotide mapping, reverse transcriptase sequencing, charge distribution analysis, and detection of rna impurities.
Moderna Therapeutics, Inc.


02/04/16
20160031047 
 Method and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system patent thumbnailMethod and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system
A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (cg-ms) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the gc-ms system, at a location between a high vacuum end of a transfer line and a mass analyzer of the gc-ms system.
Thermo Finnigan Llc


02/04/16
20160030369 
 Fkbp52 targeting agent pharmaceutical compositions patent thumbnailFkbp52 targeting agent pharmaceutical compositions
Liposomes comprising an fkbp52 targeting agent (fta) are disclosed. Pharmaceutical compositions comprising an fta, a solvent, and a surfactant are disclosed.
The Board Of Regents Of The University Of Texas System


01/28/16
20160027631 
 Measurement device, measurement apparatus, and method patent thumbnailMeasurement device, measurement apparatus, and method
A metal film of a measurement device including a transparent dielectric substrate is irradiated with first light from a transparent dielectric substrate side, an optical electric field enhanced by an optical electric field enhancing effect of a localized plasmon induced to a surface of the metal film by the irradiation is generated, light emitted from the transparent dielectric substrate side is detected, a specimen installed on a surface of a metal fine concavo-convex structure layer and a matrix agent are irradiated with second light from a side opposite to the side of the irradiation with the first light in a state where a voltage is applied to the metal fine concavo-convex structure layer through a voltage application electrode, an analysis target substance for mass spectrometry in the specimen is desorbed from the surface by the irradiation, and the desorbed analysis target substance is detected.. .
Fujifilm Corporation


01/28/16
20160027629 
 Apparatus for elemental analysis of particles by mass spectrometry patent thumbnailApparatus for elemental analysis of particles by mass spectrometry
A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
Fluidigm Canada Inc.


01/28/16
20160027628 

Improved data dependent control


A method of mass spectrometry is disclosed comprising obtaining first data at a first time and/or location and second data at a second subsequent time and/or location. A future trend or rate of change in the data is predicted from the first and second data.
Micromass Uk Limited


01/28/16
20160025742 

Synthesis and use of isotopically-labelled glycans


Isotopically-labelled glycans and their synthesis and use as internal standards in the analysis by mass spectrometry of glycan mixtures is described. The methods of synthesis described herein may be used conveniently to prepare libraries of heavy glycans for use in the qualitative and quantitative identification of glycans in natural samples..
AsociaciÓn Centro De InvestigaciÓ Cooperativa En Biomateriales


01/28/16
20160025741 

System and the detection of allergens


Methods and systems for detecting allergens using mass spectrometry are provided herein. In some aspects, a sample can be screened for the presence or quantity of ovalbumin, lysozyme, casein (isoform s1 and s2), lactoglobulin, high and low glutens, wheat, rye, oats, barley, mustard, sesame, and various types of nuts including macadamia, pistachio, brazil, walnuts, peanuts and hazelnuts by detecting one or more peptides specific to the allergen of interest using selected mrm transitions..
Dh Technologies Development Pte. Ltd.


01/28/16
20160025692 

Analysis system


An analysis system is provided with: a storage unit that stores first information associating mass spectrometry result information with an analysis condition concerning ion mobility separation; and a control unit that determines, as a first analysis condition for an ion to be measured, the analysis condition associated with the mass spectrometry result information of the first information corresponding to the mass spectrometry result information of the ion to be measured.. .
Hitachi High- Technologies Corporation


01/28/16
20160025691 

Chromatography/mass spectrometry data processing device


Using the intensity ratio of peaks on a standard mass spectrum of the target compound and peaks with the same m/z on the measured mass spectrum near the retention time of said compound, a scale factor waveform close to the chromatogram shape based on the target compound alone is computed, and m/z candidates for quantitation are extracted based on the correlation between the measured mass chromatogram of the target compound and the scale factor waveform. Furthermore, an intensity ratio is determined with reference to the m/z peaks showing the greatest scale factor on the measured mass spectrum at the measurement time point showing the greatest scale factor in the scale factor waveform, and m/z candidates for quantitation/confirmation are narrowed down based on whether they fall within an allowable range based on peak intensity ratio on the standard mass spectrum..
Shimadzu Corporation


01/28/16
20160025603 

Airborne agent collectors, methods, systems and devices for monitoring airborne agents


Air flow systems, devices and methods for monitoring airborne agents include airborne agent collectors. Airborne agent collectors for collecting and detecting the presence and/or identification of an airborne agent(s) include a soluble and hydrophilic polycaprolactone (pcl) that has been treated with a base (e.g., a base having a ph greater than 8 (e.g., naoh, nahco3, koh, na2co3, and ca(oh)2) and in some embodiments, also treated with a neutralizing agent for increasing hydrophilicity.
Diomics Corporation


01/28/16
20160024492 

Removal of dna fragments in mrna production process


The present invention describes methods of removing dna from an rna transcript during the mrna production process. The method embodies procedures for obtaining an in vitro transcription product, and removing any dna from the product.
Moderna Therapeutics, Inc.


01/21/16
20160020083 

Adjusting precursor ion populations in mass spectrometry using dynamic isolation waveforms


A mass spectrometry technique for isolating a plurality of isolated ions from a plurality of injected ions using a dynamic isolation waveform to create at least one isolation notch. Isolating the plurality of isolated ions may include collecting at least a first target ion, but not a second target ion, using the at least one isolation notch for a first period of time; changing at least one property of the at least one isolation notch; and collecting at least the first target ion and the second target ion using the at least one isolation notch for a second period of time..
President And Fellows Of Harvard College


01/21/16
20160020082 

Mass spectrometer system and method


An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage u, an amplitude v of a radio-frequency voltage, and a frequency f of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger.
Hitachi High-technologies Corporation


01/21/16
20160020080 

Sample plate for maldi-tof mass spectrometer and manufacturing the sample plate and mass spectrometry method using the sample plate


The present invention relates to a sample plate to be used for a maldi-tof (matrix assisted laser desorption ionization time of flight) mass spectrometer, and more particularly, to a sample plate for a maldi-tof mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a maldi-tof mass spectrometer so as to overcome the limits of the gas chromatography method of the related art.
Industry-academic Cooperation Foundation, Yonsei University


01/21/16
20160020076 

Collision cell for tandem mass spectrometry


A method and apparatus for tandem mass spectrometry is disclosed. Precursor ions are fragmented and the fragments are accumulated in parallel, by converting an incoming stream of ions from an ion source (10) into a time separated sequence of multiple precursor ions which are then assigned to their own particular channel of a multi compartment collision cell (40).
Thermo Fisher Scientific (bremen) Gmbh


01/21/16
20160018410 

Deep maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof


A method of analyzing a biological sample, for example serum or other blood-based samples, using a maldi-tof mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a maldi-tof sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument.
Biodesix, Inc.


01/21/16
20160018368 

Mass spectrometry s


Proposed schematic ion optical diagrams allow to developing different ms types.. .

01/21/16
20160018361 

System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry


An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges.

01/21/16
20160017397 

Monitoring a dynamic system by liquid chromatography-mass spectrometry


The present invention provides a method for monitoring of profile changes of components in a dynamic system such as a cell-free in vitro protein synthesis system by using liquid chromatography (lc) combined with mass spectrometry (ms). In an additional aspect, this invention provides a method for enhancing the yield and/or reproducibility in a cell-free protein synthesis system by modulating the level and/or activity of a protein component that has regulatory effects on the system..
Sutro Biopharma, Inc.


01/14/16
20160013040 

Ion trap mass spectrometer


An ion trap mass spectrometer including an ion trap analyzer, an ion packet injector, and an ion detector is disclosed, along with a method of mass spectrometry. The ion packet injector injects packets of ions into a field of the ion trap analyzer.
Leco Corporation


01/14/16
20160013037 

Apparatus and methods for plasma-assisted reaction chemical ionization (parci) mass spectrometry


Plasma-assisted reaction chemical ionization (parci) provides highly sensitive elemental analysis by producing positively and negatively charged ions. The parci apparatuses, kits, and methods described in this application relate to systems that comprise a chemical reaction interface (cri) containing reactant gas plasma and an ionization chamber that is downstream from the cri.
Georgetown University


01/14/16
20160013036 

Improved lock component corrections


A method of mass spectrometry is disclosed comprising initially calibrating or recalibrating a mass spectrometer at a time t0 and at the same time measuring a time of flight or mass to charge ratio m0 of one or more lockmass ions. The mass spectrometer is then operated at a subsequent time t1 and the time of flight or mass to charge ratio m1 of the one or more lockmass ions is measured at subsequent time t1.
Micromass Uk Limited


01/14/16
20160011205 

Mass spectrometry method using matrix


Where r is an alkyl group having 4 to 12 carbon atoms. The mass spectrometry method as described above, wherein an analysis object is a hydrophobic compound, particularly, a hydrophobic peptide..

01/14/16
20160007625 

Coffee drink


Provided is a coffee beverage, including the following components (a), (b), and (c): (a) at least one selected from the group consisting of catechol and pyrogallol; (b) 3,4-dicaffeoyl-1,5-quinolactone; and (c) chlorogenic acids, in which a ratio of a total peak area of the component (a) to a peak area of the component (b), ((a)/(b)), as determined by liquid chromatography-time of flight mass spectrometry (lc-tof/ms) of the coffee beverage, is from 0 to 2.0, and in which a content of the component (c) in the coffee beverage is from 0.05 to 2% by mass.. .
Kao Corporation


01/07/16
20160005582 

Ion trap mass spectrometer


A mass spectrometer including an ion source, an ion guide, a pulsed converter, and an electrostatic analyzer is disclosed, along with a method of mass spectrometry and an ion injector. The ion source generates ions, such as ions within a continuous or a quasi-continuous ion beam.
Leco Corporation


01/07/16
20160005579 

Multi-pole ion trap for mass spectrometry


An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface.
The Rockefeller University


01/07/16
20160005578 

Parallel elemental and molecular mass spectrometry analysis with laser ablation sampling


An apparatus for mass spectrometry includes a laser ablation sampler comprising a laser ablation chamber and a laser which produces a laser beam. The laser irradiates and ablates a material from a sample placed within the laser ablation chamber so as to generate an ablated sample material.
Westfaelische Wilhelms-universitaet Muenster


01/07/16
20160003836 

Photo or chemolabile conjugates for molecules detection


The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label..
Centre National De La Recherche Scientifique


01/07/16
20160003787 

Method and system for monitoring biomolecule separations by mass spectrometry


Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column.
Microsaic Systems Plc


01/07/16
20160002696 

Method to identify bacterial species by means of gas chromatography/mass spectrometry in biological samples


Method to identify bacterial classes in a biological sample, in particular a urine sample, that provides to carry out an analysis by means of gas chromatography-mass spectrometry (gc/ms) of the volatile components, such as metabolites and catabolites, of the sample in order to identify a graphic plot characteristic of a specific bacterial class.. .
Alifax Holding Spa


12/31/15
20150380230 

M/z targeted attenuation on time of flight instruments


A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a time of flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the time of flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity..
Micromass Uk Limited


12/31/15
20150380228 

An analytical apparatus utilizing electron impact ionization


An analytical apparatus (1) for mass spectrometry comprises an electron impact ioniser including an electron emitter (22) and an ionisation target zone (18). The target zone (18) is arranged to be populated with matter to be ionised for analysis.
Markes International Limited


12/31/15
20150377862 

Method to evaluate the tissue targeting of a molecule of interest


The invention relates to a method for evaluating if a molecule of interest binds or is incorporated in, at least one target tissue comprising visualizing and comparing the distribution of the molecule of interest and of at least one control compound within the target tissue or on the target tissue surface of at least one animal that has previously received the molecule of interest and/or the control compound. Advantageously, the distribution of the molecule of interest is visualized and compared with the distribution of positive and negative compounds using mass spectrometry imaging on the surface of the target tissue..
Imabiotech


12/31/15
20150377845 

Fully automated analytical determination of chloroethers in water and urine sample


A fully automated flow assisted-solid-phase microextraction (fa-spme) is developed for the determination of chloroethers in aqueous samples. A ctc combipal autosampler coupled with gas chromatography-mass spectrometry (gc-ms) is used to automate the extraction process.
King Abdulaziz City For Science And Technology


12/31/15
20150376678 

Srm assay to indicate cancer therapy


The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the alk, ros, ron, ret, ts, and/or fgfr1 proteins that are particularly advantageous for quantifying the alk, ros, ron, ret, ts, and/or fgfr1 proteins directly in biological samples that have been fixed in formalin by the methods of selected reaction monitoring (srm) mass spectrometry, or as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


12/24/15
20150371837 

Method and device for mass spectrometry


A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part.
Hitachi High-technologies Corporation


12/24/15
20150369818 

Her3 protein srm/mrm assay


The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the receptor tyrosine-protein kinase erbb-3, or her3, that are particularly advantageous for quantifying the her3 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


12/17/15
20150364315 

Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods


mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for differential background pressures where p2<p1 which generates gas flow through an unsealed, sealed or partially sealed ion trap and enhances detected signal relative to when p2=p1.. .
The University Of North Carolina At Chapel Hill


12/17/15
20150364311 

Compositions and methods for mass spectometry


The invention provides ionizing matrix compounds. These compounds are useful for mass spectrometry and ion mobility spectrometry as ionizing matrices facilitating transfer of diverse classes of analyte compounds from solid or solution states to gas-phase ions..

12/17/15
20150364307 

Systems and methods for single cell culture and analysis by microscopy and maldi mass spectrometry


Systems and methods for single cell culture and analysis by microscopy and matrix assisted laser desorption ionization mass spectrometry are disclosed. The systems and methods isolate a plurality of cells in a plurality of wells such that a predetermined number of the plurality of wells contain one and only one cell.
Massachusetts Institute Of Technology


12/17/15
20150364305 

Data processing for multiplexed spectrometry


Multiplexed spectrometry, such as multiplexed ion mobility spectrometry (ims), time-of-flight mass spectrometry (tofms), or hybrid im-tofms, is carried out on a sample, and the resulting measurement data are deconvoluted. Noise may be removed from the measurement data prior to deconvolution.
Agilent Technologies, Inc.


12/17/15
20150364302 

Optimizing drag field voltages in a collision cell for multiple reaction monitoring (mrm) tandem mass spectrometry


A collision cell has a plurality of rod electrodes arranged in opposed pairs around an axial centerline and a plurality of drag vanes arranged in the interstitial spaces between the rod electrodes. Operating the collision cell includes, applying a rod offset voltage to the rod electrodes, and varying an offset voltage applied to the drag vanes to identify a vane offset voltage with a maximum intensity for the transition.
Thermo Finnigan Llc


12/17/15
20150362504 

Quantitative peptide or protein assay


Peptide and/or protein quantitation methods, kits, and compositions, particularly useful for mass spectrometry, are provided herein based on a bathocuproine-based composition complex such as bathocuproinedisulfonic acid disodium salt hydrate complex. The methods are one-step rapid absorbance methods using small sample volumes.
Pierce Biotechnology, Inc.


12/10/15
20150357636 

Secondary battery-use active material, secondary battery-use electrode, secondary battery, battery pack, electric vehicle, electric power storage system, electric power tool, and electronic apparatus


A secondary battery includes: a cathode; an anode; and an electrolytic solution. The cathode contains an active material capable of inserting and extracting an electrode reactant.
Sony Corporation


12/10/15
20150357173 

Laser ablation atmospheric pressure ionization mass spectrometry


In an embodiment, the present invention provides an apparatus for mass spectrometry which includes a laser ablation sampler comprising a laser ablation chamber and a laser. The laser ablation chamber is configured so that the laser can irradiate and ablate a material from a sample to generate an ablated sample material.
WestfÄlische Wilhelms-universitÄt MÜnster


12/10/15
20150355193 

Methods of validating candidate compounds for use in treating copd and other diseases


The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (copd), chronic bronchitis, emphysema, refractory asthma, and other related diseases.
The Trustees Of Columbia University In The City Of New York


12/03/15
20150348768 

Combustion pretreatment-isotope dilution mass spectrometry


Provided is a combustion pretreatment-isotope dilution mass spectrometry measuring concentration of a target element for detection contained in a target sample for detection by using an isotope dilution mass spectrometry, including: pretreating the target sample for detection by combustion during an isotope dilution mass spectrometry, to thereby stabilize an isotope and further improve analysis ability, and therefore, the present invention is expected to be utilized as an element analysis method surpassing accuracy of the existing mass spectrometry method.. .
Korea Research Institute Of Standards And Science


12/03/15
20150348767 

Imaging mass spectrometry


A method of performing imaging mass spectrometry of a sample. The method comprises performing a first mass analysis of the sample using a first mass analyzer comprising a multi-pixel ion detector to obtain first mass spectral data representative of pixels of the sample.
Thermo Fisher Scientific (bremen) Gmbh


12/03/15
20150346214 

Detection of membrane proteins


According to the present invention, there is provided a method of detecting a membrane protein by mass spectrometry, the method comprising the steps of: (a) providing a solution comprising a detergent micelle in which said membrane protein is contained, wherein said solution contains a polyoxyalkylene glycol detergent; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the micelle; (d) ionising the membrane protein; (e) resolving the ionised membrane protein using the mass analyser; and (f) detecting the resolved membrane protein using the detector. Also provided are reagents for use in said method..

12/03/15
20150346183 

C peptide detection by mass spectrometry


Methods are described for measuring the amount of c peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying c peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
Quest Diagnostics Investments Incorporated


12/03/15
20150346152 

Mass spectrometry analyses on lipid and other ions using a unique workflow


The applicants' teachings provide in some aspects methods and apparatus for mass spectrometric analysis that identify the location of carbon-carbon double bonds, if any, in an analyte by (1) obtaining the m/z ratio of the intact analyte ions, (2) subjecting these ions to collision-induced dissociation and (3) determining relationships between masses and/or mass-to-charge ratios of the intact analyte ions and the fragments produced by such collision-induced dissociation. The methods and apparatus selectively subject analyte ions to ozone-induced dissociation based on those relationships and determine location(s) of carbon-carbon double bonds, if any, from reaction products of ozone-induced dissociation..
Unversity Of Wollongong


11/26/15
20150341020 

Circuit for generating a voltage waveform


A circuit for generating a voltage waveform at an output node. The circuit includes a voltage rail connected to the output node via a voltage rail switch; an anchor node connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes two or more transistors connected in series; and a control unit configured to change the voltage at the output node by controlling the voltage rail switch and the bidirectional switch so that, if a load capacitance is connected to the output node, a resonant circuit is established between the inductor and the load capacitance.
Shimadzu Corporation


11/26/15
20150340217 

Targeted analysis for tandem mass spectrometry


A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection tof device that separates ions into packets in accordance with their m/z.
Thermo Fisher Scientific (bremen) Gmbh


11/26/15
20150340216 

High mass accuracy filtering for improved spectral matching of high-resolution gas chromatography-mass spectrometry data against unit-resolution reference databases


The invention provides methods, systems and algorithms for identifying high-resolution mass spectra. In some embodiments, an analyte is ionized and analyzed using high-resolution mass spectrometry (ms) at high mass accuracy (such as ≦75 ppm or ≦30 ppm) and the obtained mass spectra are matched with one or more prospective candidate molecules or chemical formulas.
Wisconsin Alumni Research Foundation


11/26/15
20150340215 

Diathermy knife ionisation source


A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife.
Micromass Uk Limited


11/26/15
20150340213 

Method and mass spectrometry of macromolecular complexes


A method of analyzing macromolecular complex ions, such protein complex ions, by mass spectrometry and apparatus for performing the method, wherein the method comprises: introducing macromolecular complex ions into a first fragmentation device and trapping the complex ions therein for a trapping period; fragmenting the trapped complex ions in the first fragmentation device to produce monomer subunit ions; optionally selecting one or more species of subunit ions by m/z; introducing one or more of the species of subunit ions into a second fragmentation device, spatially separated from the first fragmentation device; fragmenting the subunit ions in the second fragmentation device to produce a plurality of first fragment ions of the subunit ions; and mass analyzing the first fragment ions in a mass analyzer, or subjecting the first fragment ions to one or more further steps of fragmentation to form further fragment ions and mass analyzing the further fragment ions.. .
Thermo Fisher Scientific (bremen) Gmbh


11/26/15
20150338426 

Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid


The invention relates to the detection of dha and epa. In a particular aspect, the invention relates to methods for detecting dha and epa by mass spectrometry and kits for carrying out such methods..
Quest Diagnostics Investments Incorporated


11/26/15
20150338413 

System and analysis of bio-metabolites for-use in image-guided surgery


A system for identifying a bio-marker using mass spectroscopy is provided that includes a sample receptacle configured to receive a tissue sample, a mass spectrometry apparatus configured to receive the tissue sample and analyze the tissue sample using a mass spectrometry process to generate mass spectrometry data, and a computer system that includes a computer processor having access to a non-transitory, computer-readable storage medium having stored thereon instructions. The instructions cause the computer processor to: receive the mass spectrometry data from the mass spectrometry apparatus; analyze the mass spectrometry data to determine a presence of 2-hydroxyglutarate (2-hg) in the tissue sample; and generate a report indicating a health of the tissue sample based on the presence of 2-hg in the tissue sample..

11/26/15
20150338391 

In vitro diagnostic an invasive fungal infection using maldi-toff mass spectrometry


A method for the in vitro diagnosis of an invasive fungal infection by maldi-tof mass spectrometry. The method involves, providing a liquid biological sample from a mammal, said biological sample containing, in particular, proteins and/or lipids and/or salts and/or polysaccharides and/or oligosaccharides and/or monosaccharides capable of forming complexes with said proteins and/or lipids and/or salts; treating said sample with biological liquid so as to extract said polysaccharides and/or oligosaccharides and/or monosaccharides; determining, by maldi-tof mass spectrometry, whether or not there is present among said extracted polysaccharides, oligosaccharides and/or monosaccharides, at least one given compound of interest coming from said fungal microorganism and chosen from polysaccharides, oligosaccharides and monosaccharides; and deducing, if said given compound of interest is present in said sample, that said mammal is suffering from an invasive fungal infection..
Centre National De La Recherche Scientifique


11/26/15
20150338375 

Microsecond time-resolved mass spectrometry


A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length.
Ohio University


11/19/15
20150332907 

Sample preparation and nanoelectrospray ionization mass spectrometry


Method for loading a sample of a target compound into a nanospray emitter tube for analysis by nanospray ionization mass spectrometry, wherein a cartridge having a fluid container, an inlet and an outlet is mounted onto a nanospray emitter tube on a nanospray emitter mount to form a nanospray emitter tube assembly, the assembly is mounted on a micro-centrifuge tube, a volume of the sample to be analyzed is loaded into the fluid container and the micro-centrifuge tube is spun on a centrifuge to transfer the sample into the nanospray emitter tube.. .
New Objective, Inc.


11/19/15
20150332906 

System and maldi-tof mass spectrometry


A system and method for matrix assisted laser desorption time-of-flight (maldi-tof) mass spectrometry. A method for maldi-tof mass spectrometry includes initiating a spectral analysis of a sample on a maldi-tof spectrometer.
University Of Houston System


11/19/15
20150331000 

Compositions and methods for purification and detection of hdl and apoa1


The present invention provides methods, kits, and compositions for purifying hdl molecules from a sample (e.g., blood sample) using hdl tagging molecules comprising an hdl lipophilic core binding peptide (e.g., portion of apoa1) and an affinity tag. The present invention also provides methods, kits, and compositions for detecting non-fragmented apoa1 with mass spectrometry.
Cleveland Heartlab, Inc.


11/19/15
20150330992 

Rapid discovery and screening of enzyme activity using mass spectrometry


Described herein are methods, systems, and compositions for detecting enzyme activity. In some embodiments, the reaction product(s) are coupled with a mass tag, and the enzyme activity is determiner by analyzing the reaction product(s).
Sandia Corporation


11/12/15
20150325708 

Semiconductor device


A transistor capable of being driven at high operating frequency is provided. The transistor includes first to third oxide semiconductor layers, a gate insulating layer, a gate electrode layer, and a portion in which the first to third oxide semiconductor layers are sequentially stacked.
Semiconductor Energy Laboratory Co., Ltd.


11/12/15
20150325422 

Method for ion production


A method for producing multiply charged ions is provided. In the method, a laser is used to ablate a sample comprising a matrix and an analyte.
University Of Reading


11/12/15
20150325420 

Ultrafast transimpedance amplifier interfacing electron multipliers for pulse counting applications


Systems, devices, and methods are provided for an improved mass spectrometry detection system for pulse counting applications. The detector can comprise an electron multiplier and circuitry, such as a transimpedance amplifier, that allows for the gain of the detector to be decreased, which in turn leads to a pulse counting detector with a high dynamic range.
Dh Technologies Development Pt. Ltd.


11/12/15
20150324518 

Genetic affinity of microorganisms and viruses


Selecting which sub-sequences in a database of nucleic acid such as 16s rrna are highly characteristic of particular groupings of bacteria, microorganisms, fungi, etc. On a substantially phylogenetic tree.

11/12/15
20150323554 

Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and lc/ms/ms workflow


A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the analysis of ketosterol biomarkers such as bile acid precursors from human plasma, serum or whole blood. This method is used for new born screening for cerebrotendinous xanthomatosis (ctx).
Dh Technologies Development Pte. Ltd


11/12/15
20150323545 

Selected reaction monitoring assays


Provided herein are methods for developing selected reaction monitoring mass spectrometry (lc-srm-ms) assays.. .
Integrated Diagnostics, Inc.


11/12/15
20150323513 

Quantitation of tamoxifen and metabolites thereof by mass spectrometry


Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein comprise determining the amount of norendoxifen.
Quest Diagnostics Investments Incorporated


11/12/15
20150323495 

Non-aqueous microchip electrophoresis for characterization of lipid biomarkers


The invention provides devices and methods for the detection of hydrophobic biomarkers using 3d microchip capillary electrophoresis having a non-aqueous solvent system. Hydrophobic biomarkers can be placed in a microcapillary microchannel and electrokinetically injected into a second microcapillary microchannel through a nanocapillary array membrane.
University Of Notre Dame Du Lac


11/05/15
20150318161 

High pressure mass spectrometry systems and methods


Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.


11/05/15
20150318160 

Probe for extraction of molecules of interest from a sample


A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer.

11/05/15
20150318158 

Probe for extraction of molecules of interest from a sample


The present disclosure describes a device for generating ionized molecules for analysis in a mass spectrometer. The device includes: a mesh substrate coated with an extraction phase, the extraction phase comprising a polymer that absorbs a molecule of interest from a matrix, or a polymer and solid phase microextraction (spme) particles having pores dimensioned to absorb a molecule of interest from a matrix, where the mesh substrate has a sufficiently open structure to allow fluid to flow through the mesh substrate; and a solid substrate connected to the mesh substrate to provide stability to the coated mesh substrate.

11/05/15
20150316506 

Correction of time of flight ms adc data on push by push basis


A method of mass spectrometry is disclosed comprising pulsing ions into a time of flight region and detecting the ions using an ion detector. The signal output from the ion detector is digitised to produce a digitised signal.
Micromass Uk Limited


10/29/15
20150311057 

Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method


The present invention provides an ion group irradiation device for irradiating a sample with an ion group. An ion group selecting unit is configured to select, from ions released from an ion source, at least two ion groups formed of ions having different average masses.
Canon Kabushiki Kaisha


10/29/15
20150311056 

High sensitivity electrospray interface


The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry.
University Of Notre Dame De Lac


10/29/15
20150311055 

Ionization device, mass spectrometry apparatus, mass spectrometry method, and imaging system


A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions.. .
Canon Kabushiki Kaisha


10/29/15
20150309347 

Display device


One object is to provide a transistor including an oxide semiconductor film which is used for the pixel portion of a display device and has high reliability. A display device has a first gate electrode; a first gate insulating film over the first gate electrode; an oxide semiconductor film over the first gate insulating film; a source electrode and a drain electrode over the oxide semiconductor film; a second gate insulating film over the source electrode, the drain electrode and the oxide semiconductor film; a second gate electrode over the second gate insulating film; an organic resin film having flatness over the second gate insulating film; a pixel electrode over the organic resin film having flatness, wherein the concentration of hydrogen atoms contained in the oxide semiconductor film and measured by secondary ion mass spectrometry is less than 1×1016 cm−3..
Semiconductor Energy Laboratory Co., Ltd.


10/29/15
20150309055 

Methdos for detecting estradiol by mass spectrometry


Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample..
Quest Diagnostics Investment Inc.


10/29/15
20150309001 

Methods of analyzing crude oil


The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis.
Purdue Research Foundation


10/29/15
20150308991 

Methods of detecting reverse triiodothyronine by mass spectrometry


Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample..
Quest Diagnostics Investments, Inc.


10/22/15
20150303047 

Ion trap analyzer and ion trap mass spectrometry analysis method


An ion trap analyzer, an ion trap mass spectrometry analysis method, and an ion fragmentation method are provided. The ion trap analyzer includes an ion trapping space enclosed by multiple electrodes (101, 102, 103, 11, 12, 214), where a high-frequency voltage is applied on at least a part of the electrodes, so as to generate, within the trapping space, a trapping electric field dominated by a quadratic field.
Shimadzu Corporation


10/22/15
20150301001 

Fully automated analytical determination of chloroethers in water and urine sample


A fully automated flow assisted-solid-phase microextraction (fa-spme) is developed for the determination of chloroethers in aqueous samples. A ctc combipal autosampler coupled with gas chromatography-mass spectrometry (gc-ms) is used to automate the extraction process.
King Abdulaziz City For Science And Technology


10/22/15
20150300930 

Tissue sample preparation, and maldi ms imaging thereof


Aspects of the present invention relate to a method for the preparation of samples for maldi ms imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix.
The Brigham And Women's Hospital, Inc.


10/22/15
20150299761 

Substrates and methods for preparing samples for mass spectrometry


A mass spectrometry substrate for performing adsorption and biological processing includes a porous silica-based material comprising a chemical adsorption material that captures analyte(s) of interest. A biologically active material incorporated into the porous silica-based material performs biological processing on the analyte(s) of interest..
Virgin Instruments Corporation


10/15/15
20150293116 

Ionization of chemicals in mixture at low ph by ambient ionization/mass spectrometry


A mass spectrometry-based method for analyzing an acidic organic target compound includes directing a charged solvent (44) toward a pre-acidified sample (12) comprising the target compound, to thereby ionize the pre-acidified sample (12). The method further includes directing the ionized pre-acidified sample (54) to a mass spectrometer (18), the mass spectrometer (18) being configured to identify and quantify the target compound..

10/15/15
20150293111 

Method of diagnosing galactosemia in neonatal screening


A method of diagnosing galactosemia in blood samples from neonates by determining gal-1-p concentrations before 5-7 days of life is disclosed. The removal of interfering compounds allows a more specific and therefore more accurate determination of gal-ip levels in newborn screening for galactosermia using mass spectrometry.

10/15/15
20150293093 

Vitro assays for detecting salmonella enterica serotype typhi


Provided are assays, kits and compositions for testing subjects, particularly asymptomatic subjects, to ascertain whether or not they are carriers of salmonella enterica serotype typhi. Methods for detecting the presence of salmonella enterica serotype typhi indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided..

10/15/15
20150293063 

Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging


This disclosure provides systems, methods, and apparatus for integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter.

10/15/15
20150293058 

Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry


Embodiments are directed to a method, a computer readable medium encoded with instructions that, when executed, perform a method, and a system for performing mass spectrometry analysis. Molecules of different samples may be labeled with a chemical tag, allowing a multiplexed analysis of multiple samples.



Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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