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This page is updated frequently with new Mass Spectrometry-related patent applications. Subscribe to the Mass Spectrometry RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometry RSS RSS


Date/App# patent app List of recent Mass Spectrometry-related patents
07/24/14
20140206776
 Mrm/srm assay for death receptor 5 protein patent thumbnailMrm/srm assay for death receptor 5 protein
Specific peptides, and derived ionization characteristics of those peptides from death receptor 5 (dr5) protein are provided that are particularly advantageous for quantifying the dr5 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/24/14
20140206775
 Srm/mrm assay for the fatty acid synthase protein patent thumbnailSrm/mrm assay for the fatty acid synthase protein
Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/24/14
20140206570
 Characterization of biochips containing self-assembled monolayers patent thumbnailCharacterization of biochips containing self-assembled monolayers
The present invention relates to a method of characterizing biochips with matrix-assisted laser desorption/ionization and time of flight mass spectrometry (maldi-tof ms).. .
07/24/14
20140206094
 Maldi mass spectrometry  method patent thumbnailMaldi mass spectrometry method
The problem is to provide a maldi mass spectrometry method that can be used for a mass spectrometry method by a general maldi method with which it is possible to measure multiple molecules to be measured that are contained in a sample quantitatively in a short period of time with good efficiency compared with conventional methods. The problem is solved by a maldi mass spectrometry method for a sample containing multiple molecules to be measured, which is a maldi mass spectrometry method characterized in that the multiple molecules to be measured are a saccharide mixture, a glycopeptide mixture, a glycopeptide-peptide mixture, a glycoprotein mixture, or a glycoprotein-protein mixture, and that a quantitative mass spectrum of the multiple molecules to be measured is obtained from an arbitrary point in the sample to be measured where a signal is detected without measuring and integrated averaging the entire sample to be measured..
07/24/14
20140206091
 Cross-linking compositions and related methods of isotope tagging of interacting proteins and analysis of protein interactions patent thumbnailCross-linking compositions and related methods of isotope tagging of interacting proteins and analysis of protein interactions
An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (itip), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the ms/ms spectrum.
07/17/14
20140200330
 Isolation of phosphoproteins, glycoproteins and fragments thereof patent thumbnailIsolation of phosphoproteins, glycoproteins and fragments thereof
The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. A lanthanide metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups.
07/17/14
20140199717
 Multiplex mrm assay for evaluation of cancer patent thumbnailMultiplex mrm assay for evaluation of cancer
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (er), progesterone receptor (pr), and/or antigen ki67 (ki67) proteins that are particularly advantageous for quantifying the er, pr, and/or ki67 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/17/14
20140199716
 Isotopic recoding for targeted tandem mass spectrometry patent thumbnailIsotopic recoding for targeted tandem mass spectrometry
Aspects of the present disclosure include methods for detecting a low abundance protein and methods for identifying a site of n-glycosylation on a protein. In practicing methods according to certain embodiments, a eukaryotic cell is contacted with an isotopic labeling composition and isotopically labeled n-glycosylated peptides obtained from the eukaryotic cell are assessed by liquid chromatography-tandem mass spectrometry.
07/03/14
20140183355
 High pressure mass spectrometry systems and methods patent thumbnailHigh pressure mass spectrometry systems and methods
Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
07/03/14
20140183352
 Parallel mass analysis patent thumbnailParallel mass analysis
A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device.
07/03/14
20140183350
Compact mass spectrometer
Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
07/03/14
20140183347
Multiple ion injection in mass spectrometry
This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed.
06/26/14
20140179010
Methods of detecting reverse triiodothyronine by mass spectrometry
Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample..
06/26/14
20140175276
Tandem mass spectrometer and tandem mass spectrometry method
The invention relates to a tandem mass spectrometer comprising an ionisation source (1) that can produce ions; a mass analyser comprising an ion trap (2) arranged in such a way as to receive ions from the ion source and detection means that can detect ions leaving the ion trap according to the mass m to load z (m/z) ratio thereof; ion activation means for activating ions that can fragment at least some of the ions trapped in the ion trap; and coupling means arranged between the ion trap and said ion activation means. According to the invention, the ion activation means consist of a glow discharge lamp (4) that can generate a light beam oriented towards the ion trap (2), said light beam being electromagnetic radiation in the vacuum ultraviolet wavelength range with photon energies of between 8 ev and 41 ev in such a way as to fragment at least some of the ions trapped in the ion trap (2)..
06/26/14
20140175275
Mass spectrometry assay for congenital adrenal hyperplasia
Methods are provided for detecting the amount of one or more cah panel analytes (i.e., pregnenolone, 17-oh pregnenolone, progesterone, 17-oh progesterone, dehydroepiandrosterone (dhea), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more cah panel analytes in a sample and quantifying the generated ions to determine the amount of one or more cah panel analytes in the sample.
06/19/14
20140170759
System and method for determining amino acid sequence of polypeptide
This invention discloses systems and methods for determining the sequence of amino acids in a short peptide chain that constructs a protein. The protein is firstly hydrolyzed to various short peptides and amino acid enantiomers.
06/19/14
20140170146
Methods for multiplexed drug evaluation
Methods for multiplexed delivery of agents to a solid tissue in vivo followed by assessment of efficacy with mass spectrometry are described.. .
06/19/14
20140166875
Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.. .
06/12/14
20140162902
Cell-based materials and methods for defining pharmacogenetic differences in drug metabolism
Cell lines harboring a range of polymorphisms using recombinant cytochrome p450 or other chemical-metabolizing enzymes in a parent cell line that is minimally expressing or devoid of its own cytochrome p450 protein or other chemical-metabolizing enzymes of interest can be placed into an array format to enable high throughput screening of one or more chemicals for cyp450 or other enzyme-dependent metabolism (fig. 9).
06/12/14
20140162371
Methods for detecting vitamin d metabolites by mass spectrometry
Provided are methods of detecting the presence or amount of a vitamin d metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin d metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin d metabolite in the sample.
06/12/14
20140162298
Immobilized enzymatic reactor
An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide.
06/12/14
20140162248
Use of aptamers in liquid chromatography and liquid chromatography - mass spectrometry
The present disclosure relates to the use of aptamers in solid phase extraction, chromatography and chromatography-mass spectrometry systems. More specifically, the present disclosure relates to the use of aptamers in spe and chromatography systems to selectively retain, extract and/or pre-concentrate target molecule(s) having a specific affinity for the particular aptamer(s).
06/12/14
20140162068
Intermediate transfer member and electrophotographic apparatus
The intermediate transfer member is an intermediate transfer member for electrophotography, including a surface layer having a surface for carrying toner, in which: the surface layer contains a fluorine-modified curable resin having one of an acryloyl group and a methacryloyl group, and electro-conductive inorganic particles; and the surface layer has a ratio of the number of atoms of an element derived from the electro-conductive inorganic particles to the total number of atoms to be detected through analysis of the surface by x-ray photoelectron spectroscopy of 2.5 atomic % or more and 10 atomic % or less, and a peak detected at a position corresponding to a mass-to-charge ratio [m/z] of one of m/z=71 and m/z=85 in analysis of the surface by time-of-flight secondary ion mass spectrometry.. .
06/12/14
20140158881
Compositions, methods, and kits for quantifying target analytes in a sample
A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known quantity of a second calibrator, and potentially comprising a target analyte. The first known quantity and the second known quantity are different, and wherein the first calibrator, the second calibrator, and the target analyte are each distinguishable in the single sample by mass spectrometry.
06/12/14
20140158879
Method and system of identifying a sample by analysing a mass spectrum by the use of a bayesian inference technique
A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured data set from a sample using a mass spectrometer, deconvoluting the measured data set by bayesian inference to produce a family of plausible deconvoluted data sets, inferring an underlying deconvoluted data set from the family of plausible deconvoluted data sets and using the underlying deconvoluted data set to identify and/or characterise the sample..
06/05/14
20140156612
Preparing lc/ms data for cloud and/or parallel image computing
Functionality is described for data management and querying lc/ms spectrometry data, therefore making it easier to store, retrieve, transfer, and process the mass spectrometry data. The functionality transforms a plurality of raw lc/ms files obtained from a biological experiment into a set of lc/ms images on a common m/z and rt grid compatible for image processing (e.g., time alignment, peak detection and quantification, differential analysis, etc.).
06/05/14
20140156224
Single-protein nanomechanical mass spectrometry in real time
Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (g) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution..
06/05/14
20140156206
Detection and quantification of polypeptides using mass spectrometry
The invention relates to the detection and quantification of polypeptides using mass spectrometry. Specifically, the invention provides a method for testing whether a target polypeptide is present in a sample of a set of polypeptides, a method for deriving a value for distinguishing polypeptides of a set of polypeptides from each other, a database containing values for distinguishing each polypeptide of a set of polypeptides from each other, and an apparatus for configuring a mass scan of a mass spectrometer to test whether a target polypeptide of a set of polypeptides is present in a sample of the set..
06/05/14
20140151548
Matrix for maldi mass spectrometry and maldimass spectrometry method
Provided is a matrix for maldi mass spectrometry that has a high ability of ionizing low-molecular-weight compounds, and makes it possible to make measurement in a negative ion mode. The matrix is a matrix for mass spectrometry that contains one or more compounds selected from the group consisting of compounds each represented by the following general formula (i), (ii) or (iii), and their salts thereof.
06/05/14
20140151541
Electrokinetically controlled calibrant delivery
An electrokinetic pump can be used to deliver calibrant (“lock mass”) ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery.
05/29/14
20140147921
Microsecond time-resolved mass spectrometry
A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length.
05/29/14
20140147878
Lc-ms separation and detection of vitamin d metabolites
Systems, kits, and methods for quantitation of metabolites of vitamin d by liquid chromatography-mass spectrometry (lc-ms). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([m+h]+) for the vitamin d metabolites in the ionization source (e.g., electrospray ionization (“esi”)).
05/29/14
20140145166
Light-emitting element, light-emitting device, electronic device, and lighting device
To provide a light-emitting element with high emission efficiency. In a light-emitting element including an organic compound between a pair of electrodes, the molecular weight x of the organic compound is 450 or more and 1500 or less, and the absorption edge of the organic compound is at 380 nm or more.
05/29/14
20140145073
Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy
The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion.. .
05/22/14
20140141466
Ion generation using wetted porous material
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
05/22/14
20140138541
Dual source mass spectrometry system
A dual source mass spectrometer system (10) is operable in a first mode with an lc source [lc/ms] (12) and in a second mode with a gc source [gc/ms] (18). The gc source inputs into an ion source chamber (22) for delivering the ionized output from the gc source to the mass spectrometer.
05/22/14
20140138538
Resolution and mass range performance in distance-of-flight mass spectrometry with a multichannel focal-plane camera detector
A distance-of-flight mass spectrometer (dofms) includes an ion source, a field-free region, an extraction region in which ions are accelerated, and a spatially-selective detector for spatially selectively detecting ions extracted by the extraction region. A method for operating a distance-of-flight mass spectrometer dofms comprises controlling a detection time in such a way as to permit ions with progressively greater mass-to-charge (m/z) ratios to enter the extraction region of the dofms at positions which will permit the ions with progressively greater m/z ratios to enter the detector of the dofms, generating a component mass spectrum at each selected value of detection time, and then assembling a composite mass spectrum by shifting the distance-of-flight axis of each component mass spectrum by a distance corresponding to the change in detection time..
05/15/14
20140134654
Systems and apparatus for indicating risk of coronary stenosis
A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one cholesteryl ester measured in a blood sample collected from said subject; and then (b) inputting the age and gender of said subject; and then (c) generating in said computer from said cholesteryl ester level input, said age input and said gender input a prediction of risk and/or an indication of extent of coronary stenosis blood sample by mass spectrometry.. .
05/15/14
20140134642
Characterization of biochips containing self-assembled monolayers
The present invention relates to a method of characterizing biochips with matrix-assisted laser desorption/ionization and time of flight mass spectrometry (maldi-tof ms).. .
05/15/14
20140134236
Individualized cancer therapy
In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue from such patient; (c) extracting total protein and rna from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue using 2d dige and mass spectrometry; (e) identifying proteins that are expressed in such cancer tissue at significantly different levels than in the normal tissue; (f) obtaining a gene expression profile of the cancer tissue and normal tissue using microarray technology and comparing the results thereof to the protein expression profile; (g) prioritizing over-expressed proteins by assessing the connectivity thereof to other cancer-related or stimulatory proteins; (h) designing an appropriate rna interference expression cassette to, directly or indirectly, modulate the expression of genes encoding such prioritized proteins; (i) incorporating said cassette into an appropriate delivery vehicle; and (j) providing the patient with an effective amount of the delivery vehicle to, directly or indirectly, modify the expression (i.e., production) of such proteins.. .
05/15/14
20140132607
Chromatograph mass spectrometry data processing device
A measurement eic for quantitative ions and a measurement eic for ions to be confirmed in the vicinity of the retention time of a target compound are displayed in an overlapping manner in a chromatogram display area. In addition, a standard center line corresponding to a standard value of the confirmation ion ratio, which expresses the ratio of the intensity of the confirmation ions to the intensity of the quantitative ions in the target compound and an upper limit line and a lower limit line demonstrating the permissible range of the intensity of the confirmation ions are displayed in an overlapping manner on the eic.
05/15/14
20140131686
Light-emitting element, light-emitting device, lighting device, and electronic device
To provide a light-emitting element including a novel compound, which is capable of being used for a transport layer, a host material, or a light-emitting material in a light-emitting element. A light-emitting element which includes an el layer between a pair of electrodes.
05/15/14
20140131570
Liquid chromatography mass spectrometer device
The purpose of the present invention is to provide a mass spectrometer with high detection sensitivity to generate fine charged droplets and thereby improve the efficiency of sample ionization, and to reduce large droplets with high ionic strength. The present invention includes: liquid chromatograph separating means that separates a sample solution into components; a sample sprayer that sprays as droplets the sample solution separated and eluted by the liquid chromatograph separating means; ion generating means that charges the droplets and generates ions; a mass spectrometer that receives the ions and performs mass spectrometry on the ions; and a desolvation unit that removes a solvent contained in the charged droplets, wherein the desolvation unit includes a desolvation flow path chamber through which the charged droplets pass, heating means for heating the desolvation flow path chamber, and a helical droplet flow path formed in the desolvation flow path chamber..
05/15/14
20140131567
Targeted analysis for tandem mass spectrometry
A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source (10) and an ion injector (21, 23) injects ions towards a downstream ion guide (50, 60) via a single or multi reflection tof device (30) that separates ions into packets in accordance with their m/z.
05/08/14
20140127825
Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof
Quantification of vitamin d2, vitamin d3, and the monohydroxy and diihydroxy metabolites of vitamin d2 and vitamin d3, can comprise labeling analytes with mass spectrometry (ms) tagging reagents and performing lc-msms analysis of the labeled analytes. The labeled analytes can include a labeled standard and can have distinct retention times on a reversed phase column, as well as distinct masses.
05/08/14
20140127734
Method of detecting at least one mechanism of resistance to cephalosporins by mass spectrometry
The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a cephalosporin, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism..
05/08/14
20140124780
Display device
One object is to provide a transistor including an oxide semiconductor film which is used for the pixel portion of a display device and has high reliability. A display device has a first gate electrode; a first gate insulating film over the first gate electrode; an oxide semiconductor film over the first gate insulating film; a source electrode and a drain electrode over the oxide semiconductor film; a second gate insulating film over the source electrode, the drain electrode and the oxide semiconductor film; a second gate electrode over the second gate insulating film; an organic resin film having flatness over the second gate insulating film; a pixel electrode over the organic resin film having flatness, wherein the concentration of hydrogen atoms contained in the oxide semiconductor film and measured by secondary ion mass spectrometry is less than 1×1016 cm−3..
05/08/14
20140124661
Multipole ion guide ion trap mass spectrometry with ms/msn analysis
A time-of-flight mass analyzer includes a multipole ion guide located in the ion flight path between the ion source and the flight tube of the time-of-flight mass analyzer. The multipole ion guide can be positioned in the ion path between the ion source and the ion pulsing region of the tof mass analyzer.
05/01/14
20140120565
Neutron encoded mass tags for analyte quantification
The invention provides mass spectrometry methods, compositions and systems which enable a unique platform for analyte quantitation accessing very high degrees of multiplexing and accurate quantification, particularly well-suited for a range of quantitative analysis for proteomics applications. Embodiments of the present methods and systems combine isotopic coding agents characterized by very small differences in molecular mass with mass spectrometry methods providing large resolving power to provide relative or absolute analyte quantification in a large number of samples..
05/01/14
20140120549
High sensitivity quantitation of peptides by mass spectrometry
The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels).
05/01/14
20140117225
Method for analyzing glycan structure
In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of cid energy; creating an energy-resolved profile including yield curves representing relationships between (i) a value of the cid energy and (ii) measured amounts of specific types of product ions; preparing a reference profile, and identifying a glycan structure of a test material by comparing the energy-resolved profile with the reference profile.. .
05/01/14
20140117219
Dynamic resolution correction of quadrupole mass analyser
A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition.. .
05/01/14
20140116112
Methods for determining the presence or absence of contaminants in a sample
Methods are provided for rapidly determining the presence or absence of large numbers of contaminants in a test sample, such as a raw material intended for use in the preparation of a nutraceutical. The disclosed methods employ gas chromatography-mass spectrometry techniques together with the specific use of software in combination with a database to analyze data collected after ionization of the sample and determine the presence or absence of the contaminants in the sample..
05/01/14
20140116111
Gas chromatograph mass spectrometer
A gas chromatograph mass spectrometer including: an oven for gas chromatography, a mass spectrometry part, a sample vaporization chamber, a gas supply part, and a control part. When the replacement operation of a septum or a glass insert begins, the control part controls the gas supply part so that the flow rate of a carrier gas has a constant pressure and then controls heaters so that temperature is equal to or less than a temperature at which replacement is possible.
04/24/14
20140110661
Multinozzle emitter arrays for ultrahigh-throughput nanoelectrospray mass spectrometry
The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole.
04/24/14
20140110574
Transient level data acquisition and peak correction for time-of-flight mass spectrometry
Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement transient-level data acquisition and peak correction in a time-of-flight mass spectrometer. Transient spectra including analyte peaks and reference mass peaks are recorded, from which a set of averaged peak centroids of the reference masses is generated.
04/17/14
20140103207
Mass spectrometry device
When a specimen from a specimen ionizing unit is not sufficiently ionized, is caused to remain in sites other than a pore in an introducing section and be deposited as a product such as an oxide or carbide, which causes a deterioration in the performance of the mass spectrometry device. The mass spectrometry device has a specimen ionizing section for ionizing a specimen, a specimen-introduction regulating chamber into which ions of the ionized specimen are introduced, a differential evacuation chamber located downstream of the specimen-introduction regulating chamber, and an analyzing section located at the downstream side of the differential evacuation chamber, in which a discharge generating means is formed for generating an electric discharge inside the specimen-introduction regulating chamber and/or the differential evacuation chamber.
04/10/14
20140099725
Methods for the analysis of glycoproteins or glycopeptides by mass spectrometry
A method for the analysis of samples including one or more glycopeptides including the steps of separating one or more glycopeptides using a chromatography system to produce a chromatographic eluent, adding a supercharging reagent to the chromatographic eluent, providing the chromatographic eluent and supercharging reagent to a mass spectrometer, ionizing said chromatographic eluent and supercharging reagent in an ion source to produce glycopeptide ions, performing at least one ion ion reaction on at least some of the glycopeptide ions to produce fragment ions, mass analyzing the fragment ions to produce ion ion reaction mass spectral data, and interpreting the ion ion reaction data mass spectral data to provide structural information relating to the glycopeptide.. .
04/03/14
20140094594
Immunoaffinity isolation of modified peptides from complex mixtures
The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (ms), tandem mass spectrometry (ms-ms), and/or ms3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide.
04/03/14
20140093968
Method for highly multiplexed quantitation of peptides by mass spectrometry and mass labels therefor
Disclosed herein are isobaric labeling reagent sets useful for multiplexed quantitation of peptides. The isobaric labeling reagent sets include a collection of at least two isobaric labeling reagents having first and second reporter groups with the same nominal mass but different isotopic substitutions and consequently different exact masses.
04/03/14
20140093899
Thyroglobulin quantitation by mass spectroscopy
Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample..
04/03/14
20140090199
Cleaning sheet, carrying member with a cleaning function and method of cleaning substrate processing equipment
A cleaning sheet comprising a cleaning layer and a releasable protective film laminated on the cleaning layer, wherein each of the relative intensities of the fragment ions of ch3si+, c3h9si+, c5h15si2o+, c5h15si3o3+, c7h21si3o2+, ch3sio−, ch3sio2− and si+ in the cleaning layer, when the protective film is peeled off the cleaning layer, is 0.1 or less according to time-of-flight secondary ion mass spectrometry, relative to c2h3+ in the case of positive ion or o− in the case of negative ion.. .
04/03/14
20140090196
Cleaning sheet, carrying member with a cleaning function and method of cleaning substrate processing equipment
A cleaning sheet comprising a cleaning layer and a releasable protective film laminated on the cleaning layer, wherein each of the relative intensities of the fragment ions of ch3si+, c3h9si+, c5h15si2o+, c5h15si3o3+, ch3sio−, ch3sio2− and si+ in the cleaning layer, when the protective film is peeled off the cleaning layer, is 0.1 or less according to time-of-flight secondary ion mass spectrometry, relative to c2h3+ in the case of positive ion or o− in the case of negative ion.. .
03/27/14
20140088885
Method, an apparatus, and a computer program product for identifying metabolites from liquid chromatography-mass spectrometry measurements
The present invention relates to a method for identifying metabolites present in a set of samples. The method may include: (a) forming a plurality of peak-groups, wherein each peak-group comprises mass peaks representative of a specific ion in each chromatographic run; (b) forming a plurality of clusters, wherein each cluster comprises at least one peak-group of (a) each having similar chromatographic profiles; and (c) generating a list of metabolite predictions, wherein each metabolite prediction is selected from the plurality of clusters of (b)..
03/27/14
20140088884
Methods of source attribution for chemical compounds
Methods of determining the source of an unknown sample are disclosed. Mass spectra from possible sources are obtained using two-dimensional gas chromatography coupled with time-of-flight mass spectrometry.
03/27/14
20140087408
Information acquisition method
The present invention relates to an information acquisition method of acquiring information of distribution of a protein or peptide in a sample based on mass information obtained by mass spectrometry of the protein or peptide. The method includes mass spectrometry of a definite region of the sample after limited proteolysis of the protein or peptide and acquisition of information relating to distribution using an ion peak that has a two-dimensional intensity distribution having a pearson product-moment correlation coefficient of 0.5 to more and 1.0 or less in the definite region against the two-dimensional intensity distribution of the parent ion of the protein or the peptide subjected to the limited proteolysis and has a peak intensity ratio of larger than 1.0 against the peak intensity of the integrated spectrum of the parent ion in the definite region, wherein the m/z of the ion peak is greater than 500..
03/27/14
20140084156
Radio frequency (rf) ion guide for improved performance in mass spectrometers at high pressure
Ion guides for use in mass spectrometry (ms) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (dc or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range.
03/27/14
20140084153
Nanoparticulate assisted nanoscale molecular imaging by mass spectrometery
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source..
03/27/14
20140084152
Matrix additive for mass spectrometry
Where r is an alkyl group having 6 to 10 carbon atoms and the substituted carboxyl group and hydroxyl group are ortho or meta to each other. A matrix additive for mass spectrometry, which is represented by the above formula (i).
03/27/14
20140084151
Matrix assisted laser desorption ionisation mass spectrometry imaging (maldi-msi)
A method of preparing a sample for matrix assisted laser desorption ionisation mass spectrometry imaging analysis by a two-step process. Firstly, a maldi matrix is dusted on to the sample followed by a spray of a suitable solvent onto the dusted sample.


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Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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