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This page is updated frequently with new Mass Spectrometry-related patent applications. Subscribe to the Mass Spectrometry RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometry RSS RSS



Date/App# patent app List of recent Mass Spectrometry-related patents
07/30/15
20150212132 
 Setting ion detector gain using ion area patent thumbnailnew patent Setting ion detector gain using ion area
A control system and method of determining a signal to noise (s/n) ratio of an ion detector system, including an ion detector, electron multiplier or photomultiplier, operates by determining an area of a noise peak, determining an area of a signal peak and determining a ratio of the area of the signal peak to the area of the noise peak. Based thereon, the signal to noise ratio can be optimised.
Micromass Uk Limited


07/30/15
20150212098 
 Diagnostic assay for alzheimer's disease patent thumbnailnew patent Diagnostic assay for alzheimer's disease
The present invention relates to the field of alzheimer's disease (ad). More specifically, the present invention provides methods and compositions useful in diagnosing and assessing ad.
The Johns Hopkins University


07/30/15
20150212055 
 Sensitive  measuring cis-diol containing compounds in plasma using 2d-lc-ms/ms patent thumbnailnew patent Sensitive measuring cis-diol containing compounds in plasma using 2d-lc-ms/ms
The present invention provides methods for determining the amount of cis-diol containing compounds in a biological samples using mass spectrometry, particularly catecholamines (dopamine, epinephrine, norepinephrine) in a plasma sample. After a sample is mixed with an internal standard, extracted with a two-step liquid-liquid extraction process utilizing phenylboronic acid chemistry, and then derivatized with a benzoyl chloride-like agent, relevant moieties are then separated chromatographically and detected by ms/ms whereby specific ion transitions are monitored.
National Medical Services, Inc.


07/30/15
20150211955 
 Detection method and facility for checking sealed products for leaks patent thumbnailnew patent Detection method and facility for checking sealed products for leaks
The invention concerns a detection method for checking sealed product packages for leaks, characterised in that it comprises the following steps: at least one previously sealed product (2) is placed in an air, nitrogen, or oxygen atmosphere, in a chamber (3) (step 101), the pressure in the chamber (3) is lowered to a secondary vacuum pressure below 10−1 mbar and, while continuing the secondary vacuum pumping of the chamber (3), the gases contained in the chamber are ionised to monitor the change in the chamber (3) of the concentration of at least one gaseous species of the gas volume contained within the sealed product (2) chosen from among nitrogen, oxygen, or argon, by analysis by optical emission or mass spectrometry (step 102).. .
Adixen Vacuum Products


07/23/15
20150206733 
 Techniques for performing mass spectrometry patent thumbnailTechniques for performing mass spectrometry
Techniques are described for performing mass spectrometry. A quadrupole, or more generally, an electrode-based device, performs mass filtering for selectively filtering ions.
Waters Technologies Corporation


07/23/15
20150206726 
 Method and system for the quantitative chemical speciation of heavy metals and other toxic pollutants patent thumbnailMethod and system for the quantitative chemical speciation of heavy metals and other toxic pollutants
This invention relates to systems and methods for measuring quantitatively multiple species or heavy metals, including mercury, and other toxic pollutants. More specifically, the systems and methods of the invention allows for determination of the analytes even at very low concentration, through concentration on a collection interface, desorption and analysis by mass spectrometry.

07/23/15
20150204883 
 Method for detecting at least one mechanism of resistance to glycopeptides by mass spectrometry patent thumbnailMethod for detecting at least one mechanism of resistance to glycopeptides by mass spectrometry
The present invention relates to a method of detection, for at least one microorganism contained in a sample, of at least one marker of resistance to a glycopeptide, including the detection, by mass spectrometry, of at least one peptide or protein of said microorganism. Preferably, the glycopeptide is vancomycin.
BiomÉrieux


07/16/15
20150200083 
 Sample collection in compact mass spectrometry systems patent thumbnailSample collection in compact mass spectrometry systems
mass spectrometry systems include a core featuring an ion source, an ion trap, and an ion detector connected along a gas path, a pressure regulation subsystem connected to the gas path and configured to regulate a gas pressure in the gas path, a sample pre-concentrator connected to the gas path, where the sample pre-concentrator includes an adsorbent material, and a controller connected to the sample pre-concentrator, where during operation of the system, the controller is configured to heat sample particles adsorbed on the adsorbent material to desorb the particles from the adsorbent material and introduce the desorbed particles into the gas path, and a pressure difference between a gas pressure in the sample pre-concentrator and a gas pressure in at least one of the ion source, the ion trap, and the ion detector when the desorbed particles are introduced into the gas path is 50 mtorr or less.. .
908 Devices Inc.


07/16/15
20150198574 
 Automated microextraction technique for the analysis of n-nitrosoamines in water patent thumbnailAutomated microextraction technique for the analysis of n-nitrosoamines in water
An automated headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry for the determination of four n-nitrosoamines in groundwater samples is developed. Response surface methodology technique was employed to investigate the optimized extraction conditions of headspace solid-phase microextraction using combipal autosampler.
King Fahd University Of Petroleum And Minerals


07/09/15
20150194296 
 Tandem time-of-flight mass spectrometry with non-uniform sampling patent thumbnailTandem time-of-flight mass spectrometry with non-uniform sampling
A method and apparatus are disclosed for parallel all-mass tandem mass spectrometry employing multi-reflecting time-of-flight analyzer for both ms stages, preferably arranged within the same analyzer to secure ultra-high resolution. Sensitivity and speed of tof-tof tandem are enhanced by non-redundant multiplexing based on signal sparseness and on avoiding repetitive signal overlaps at multiple repetitions of true fragment signals.
Leco Corporation


07/09/15
20150192590 

Method and analyzing biomolecules using raman spectroscopy


The present invention provides an apparatus having a sample separation unit, a raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of raman spectroscopy and mass spectrometry.
Japan Science And Technology Agency


07/09/15
20150191764 

Method for detecting susceptibility of microorganisms to chemical agents


A method for detecting susceptibility of microorganisms to chemical agents or antibiotics through a combination of exposing the microorganisms to the chemical agents or antibiotics after having exposed the microorganisms to a stress response-inducing stimulus and subsequently analyzing the response of the microorganisms by mass spectrometry.. .
Idmic Sa


07/02/15
20150187558 

Pulse-burst assisted electrospray ionization mass spectrometer


The present invention relates to a mass spectrometer system, which combines laser desorption with pulse bursts comprising a train of ultrashort pulses and electrospray ionization. The pulse separation between individual pulses within the pulse burst is selected such that transient phenomena on an irradiated sample do not fully relax between individual pulses.
Imra America, Inc.


07/02/15
20150187556 

Method to generate data acquisition mass spectrometry


A process for automatically creating a measurement method suitable for plasma ion source mass spectrometry, including: semi-quantitatively measuring all elements in the sample that affect the measurement; determining a plasma condition based on the total concentration of the semi-quantitatively measured elements; for each of the semi-quantitatively measured elements, estimating signal strengths of the element and an interference component in the sample to be measured and based on the resultant estimates, estimating the concentration of the element; and, based on the estimated signal strengths of the elements and the interference components and the estimated concentrations of the elements, creating at least one mass spectrometry method including at least one of: (1) a plasma condition; (2) an internal standard to be added to the sample; (3) a tuning condition for the collision/reaction cell; (4) a mass-to-charge ratio used in the mass spectrometer; and (5) an integration time used in the mass spectrometer.. .
Agilent Technologies, Inc.


07/02/15
20150187554 

Mass spectrometer


Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer..
Hitachi High-technologies Corporation


07/02/15
20150187553 

Mass spectrometry data display device and mass spectrometry data display program


A mass spectrometry data display device in which the mass axis (m/z axis) is made into a ring shape and the intensity axis is the radial direction thereof, and peak information (in the drawing, the compound name and structural formula candidates) are arranged in a ring shape in correspondence with the peaks along the outer circumference of the mass spectrum and displayed together therewith on a screen.. .
Shimadzu Corporation


07/02/15
20150187552 

High voltage power supply filter


Systems, devices, circuits, and methods are provided for an improved mass spectrometry detection system that comprises at least one component that operates at a high voltage. A number of high voltage filters or circuits are provided for reducing noise from high voltage power supplies that produce positive and negative voltages.
Dh Technologies Development Pet. Ltd.


06/25/15
20150179419 

Method for mass spectrometer with enhanced sensitivity to product ions


A mass spectrometry method comprises: introducing a first portion of a sample of ions including precursor ions comprising a first precursor-ion mass-to-charge (m/z) ratio into a first mass analyzer; transmitting the precursor ions from the first mass analyzer to a reaction or fragmentation cell such that a first population of product ions are continuously accumulated therein over a first accumulation time duration; initiating release of the accumulated first population of product ions from the reaction or fragmentation cell; continuously transmitting the released first population of product ions from the reaction cell to a second mass analyzer; transmitting a portion of the released first population of product ions comprising a first product-ion m/z ratio from the second mass analyzer to a detector; and detecting a varying quantity of the product ions having the first product-ion m/z ratio for a predetermined data-acquisition time period after the initiation of the release.. .
Thermo Finnigan Llc


06/18/15
20150170893 

Methods and performing mass spectrometry


The present disclosure relates, in part, to ms apparatus, methods, and/or software, having improved selectivity, sensitivity, specificity, resolution, mass accuracy and dynamic range over conventional ms technologies. In particular, the technology relates to apparatus, methods, and/or software wherein a combination of in-source fragmentation, ion mobility separation, and/or time-aligned parallel (tap) sample ion fragmentations are utilized in mass spectrometry for the analysis of samples..
Waters Technologies Corporation


06/18/15
20150168430 

Trapping reagents for reactive metabolites screening


The present invention provides compounds of formula (i) and (ii): (i) (ii) wherein r1, r2, r4, r5, r6, x and n are as defined herein, and wherein r3 is hydrogen or a sulfur protecting group. Compounds of formula (i) and (ii), wherein r is hydrogen, may be useful in methods for detecting a reactive metabolite in a sample, e.g., wherein the metabolite is generated from the metabolism of a test compound, and wherein the metabolite and the compound of formula (i) or (ii) react to form a detectable adduct, e.g., detectable by mass spectrometry..
Biogen Idec Ma Inc.


06/18/15
20150168421 

Srm methods in alzheimer's disease and neurological disease assays


Provided herein are methods for developing selected reaction monitoring mass spectrometry (lc-srm-ms) assays.. .
Integrated Diagnostics, Inc.


06/18/15
20150168417 

Universal antigen retrieval compounds and methods of use


Provided herein are methods, compounds, mixtures and formulations of antigen retrieval agent useful in retrieving antigens and improving the detection of amino acids, peptides and proteins or epitopes thereon in a tissue fixed with aldehyde-based cross-linking agents. Contacting the fixed tissue with a solution of the aldehyde scavenging agent causes reactivity with the aldehyde moieties to retrieve antigens and improve detection of the amino acids, peptides and proteins or epitopes.
University Of Houston System


06/18/15
20150168388 

Multiplexed analyses of test samples


The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule.
Somalogic, Inc.


06/18/15
20150165550 

Analytical laser ablation of solid samples for icp, icp-ms, and fag-ms analysis


This invention is improved laser ablation of solid samples analyzed by inductively coupled plasma (icp), icp mass spectrometry, or flowing afterglow mass spectrometry. A mirror-with-hole eliminates chromatic aberration in sample viewing and allows rad-hardening for radiation hot cell analysis of nuclear waste.

06/11/15
20150162177 

Method for analyzing sample components


Described herein is a method and system for on-line coupling of capillary isoelectric focusing (cief) to high-resolution mass spectrometry in which a sheath flow buffer comprising polar organic solvent and organic acid is used as both an immobilization solution for (cief) and an ionization solution for electrospray ionization (esi).. .
C/o University Of Notre Dame Du Lac


06/11/15
20150160377 

Fine structure, optical member, antireflection film, water-repellent film, substrate for mass spectrometry, phase plate, process for producing fine structure, and process for producing antireflection film


Provided are an antireflection film having a high antireflection effect and a production process therefor, an optical member excellent in antireflection effect, a water-repellent film having excellent water repellency, a substrate for mass spectrometry having high detection sensitivity, a high-accuracy phase plate, and a fine structure that can be used in the foregoing and a production process therefor. The fine structure is a structure, including multiple conical portions on a surface thereof, in which the conical portions have a mesostructure; and the mesostructure includes a structure having mesopores..
Canon Kabushiki Kaisha


06/11/15
20150160233 

Identification and quantification of intact glycopeptides in complex samples


Illustrative embodiments of methods and apparatus for identifying one or more intact glycopeptides in a sample are disclosed. According to one illustrative embodiment, a method may comprise receiving data representing a plurality of mass spectra obtained from mass spectrometry of the sample, scoring data representing each of the plurality of mass spectra against data associated with target glycopeptides, and identifying one or more intact glycopeptides in the sample based at least in part on the scoring of the data representing each of the plurality of mass spectra..
Texas Tech University System


06/11/15
20150160232 

Automatic amino acid sequencing of glycopeptide by y1 ions


Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation.
Academia Sinica


06/11/15
20150160231 

Identification of metabolites from tandem mass spectrometry data using databases of precursor and product ion data


Techniques for identifying metabolites in a sample may utilize observed precursor and product ion data obtained by subjecting the sample to tandem mass spectrometry (ms/ms). The techniques may include first accessing a database of precursor ion data to identify one or more matching candidate metabolites in the database that match the observed precursor ion data.
Premier Biosoft


06/11/15
20150160162 

User interfaces, displaying multi-dimensional data for ion mobility spectrometry-mass spectrometry


A user interface, and related systems and methods, are provided for displaying multi-dimensional spectrometric data obtained from ims-ms operations. The user interface displays such data in alternative data plots, such as drift spectra, mass spectra, and multi-dimensional maps.
Agilent Technologies, Inc.


06/04/15
20150155152 

Mass spectrometry apparatus


The mass spectrometry apparatus is constituted by a sample plate to which a measurement target substance is adhered, the sample plate being transparent to a laser beam; a support mount on which the sample plate is placed, a part of the support mount being a light transmitting portion that transmits a laser beam; a light irradiation unit that exposes the measurement target substance to a laser beam from the back side of the sample plate and is provided with a laser source that outputs a laser beam, a collecting lens that collects a laser beam onto the measurement target substance, and an aberration-correction mechanism that corrects aberration which occurs when the laser beams are collected; and a detector that detects the measurement target substance which has been desorbed from the surface of the sample plate and ionized, by being irradiated with a laser beam.. .
Fujifilm Corporation


06/04/15
20150155147 

Targeted analysis for tandem mass spectrometry


A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection tof device that separates ions into packets in accordance with their m/z.
Thermo Fisher Scientific (bremen) Gmbh


06/04/15
20150155132 

Mass spectrometer and mass image analyzing system


The mass spectrometer has a chamber in which a sample is disposed, an irradiation unit for emitting particles to the sample, and an extraction electrode which leads secondary ions emitted from the sample to a mass spectrometry unit, in which the irradiation unit switches a first mode of emitting primary ions for causing the secondary ions to be emitted from the sample and a second mode of emitting particles containing water molecules to be made to adhere to the sample and emits the particles to the sample.. .

06/04/15
20150153348 

Biomarkers for ovarian cancer: beta 2 microglobulin


The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer or non-ovarian cancer.
Vermillion, Inc.


05/28/15
20150148260 

Analyte mass spectrometry quantitation using a universal reporter


Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.. .

05/28/15
20150147776 

Mass spectrometry analysis of microorganisms in samples


The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
Purdue Research Foundation


05/28/15
20150144783 

Glycopeptide analyzer


The same sample s is analyzed using an ion-trap (it) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (tof) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an it mass spectrum and a tof mass spectrum from the measured results.
Shimadzu Corporation


05/28/15
20150144780 

Method of ms/ms mass spectrometry


A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to electron capture dissociation (“ecd”) at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected.
Micromass Uk Limited


05/28/15
20150144777 

Multiple solid phase micro-extraction thermal desorption ionization device, mass spectrometer and analytical mass spectrometry


A multiple solid phase microextraction (m-spme) thermal desorption ionization device which desorbs an analyte and moves it into an entry of a mass spectrometer for mass spectrometry analysis is provided. The device has a charge producing unit, a heating unit and a sampling unit.
National Sun Yat-sen University


05/21/15
20150140600 

Mass spectrometry quantitation of p450 isoforms in hepatocytes


A method for screening a drug for cytochrome p450 (cyp) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome p450 isoform. The isoforms can be selected from 2b6, 3a4, 1a2, and 3a5 isoforms.
Dh Technologies Development Pte. Ltd.


05/21/15
20150140593 

Retention index standards for liquid chromatography


A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (lc-ms) methods, more especially for lc-ms methods employing electrospray (esi) or atmospheric pressure chemical ionization (apci) ionization systems.. .
National Research Council Of Canada


05/21/15
20150136973 

Pulsed ion beam source for electrospray mass spectrometry


Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry.
Academia Sinica


05/21/15
20150136972 

Analysis of microbes by maldi mass spectrometry


The invention relates to methods for the mass spectrometric analysis of microbes, in particular to a transfer method of microbes that are required to be identified from agar plates onto mass spectrometric sample supports and their preparation for ionization by matrix-assisted laser desorption (maldi). Microbes from microcolonies which have grown on the agar plates after a culture time of only six to eight hours are transferred with a high transfer yield onto contact surfaces of suitable size by direct contact and cell disrupted on the contact surface; the released proteins are prepared with matrix material on the contact surface as maldi samples.
Bruker Daltonik Gmbh


05/21/15
20150136969 

Method of identifying precursor ions


A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analysing the fragment or product ions; determining the start and end times at which a first fragment or product ion is detected; using said start and end times to determine the start and end times at which a precursor ion of said first fragment or product ion is transmitted by said mass analyser; and using the start and end times at which the precursor ion is transmitted by said mass analyser to determine a mass to charge ratio of said precursor ion. The present invention enables precursor ion peaks to be resolved from the fragment data even when a low resolution mass analyser is used to analyse the precursor ions..
Micromass Uk Limited


05/21/15
20150136968 

Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


05/14/15
20150133342 

Mrm-ms signature assay


The present invention relates to mass spectrometry methods employing multiple reaction monitoring (mrm) in the field of cancer therapeutics, specifically prostate cancer and melanoma.. .

05/14/15
20150132854 

Tuned synthetic dendrimer calibrants for mass spectrometry


Provided are synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative ease and rapidity of synthesis, comparatively low cost, long shelf life, high purity, and amenability to batch synthesis as mixtures.

05/14/15
20150130810 

Mass spectrometry data processing device


A data processing device in which, on a screen where an ms spectrum for a retention time designated by the analyst is displayed in the upper area and an ms2 spectrum for a precursor ion selected automatically based on the ms spectrum is displayed in the lower area, when an “on” button in a precursor parameter display selection frame in the top part is clicked, excluded ion and priority ion information for that retention time is collected and the m/z ranges and are displayed in a specified display color on the ms spectrum. As a result, it becomes possible to see at a glance whether the precursor ion indicated by upward arrow corresponds to an excluded ion or priority ion..

05/14/15
20150129762 

Reducing interferences in isobaric tag-based quantification


Methods and systems for performing mass spectrometry of analytes labeled with isobaric tags are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can enable enhanced discrimination between an analyte of interest and one or more interfering species when using isobaric tagging techniques..

05/14/15
20150129761 

Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy


The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion.. .

05/14/15
20150129758 

Systems and methods for sequencing peptides by mass spectrometry


The number of atoms present in an ion of a molecule is identified using a mixture of different forms of the molecule. A mass spectrometer analyzes a mixture of at least two forms of the molecule using one or more ion scans producing a mass spectrum.

05/14/15
20150129757 

Systems and methods for using variable mass selection window widths in tandem mass spectrometry


Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.

05/07/15
20150126406 

Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor


Disclosed herein are isobaric labeling reagent sets useful for multiplexed quantitation of peptides. The isobaric labeling reagent sets include a collection of at least two isobaric labeling reagents having first and second reporter groups with the same nominal mass but different isotopic substitutions and consequently different exact masses.
Thermo Finnigan Llc


05/07/15
20150126384 

Prognostic biomarkers in patients with ovarian cancer


The present invention provides methods for assessing an ovarian cancer patient's survival status. Also, methods for evaluating the ovarian cancer state of a patient are described herein.
Vermillion, Inc.


05/07/15
20150125877 

Weak affinity chromatography


The present invention provides methods for analyzing a target compound from a biological sample. In one aspect, a method for analyzing a target compound in a biological sample can comprise delivering a biological sample through an affinity column, the affinity column having a binding ligand coupled to a stationary structural support, wherein the affinity column has a high density of the binding ligand per the stationary structural support and wherein the binding ligand has been preselected to cause weak affinity separation zonal retardation of the target compound from the biological sample forming a target compound fraction and a biological sample fraction and detecting the target compound by mass spectrometry..

05/07/15
20150123825 

Techniques for compressing mass spectrometry data in real-time


Techniques are described for performing data compression of a first data set including data points in a plurality of dimensions. First processing is performed to determine a second set of final sums.
Waters Technologies Corporation


05/07/15
20150123012 

Sample plate using maldi-tof mass spectrometer and manufacturing the sample plate


A sample plate in use with a maldi-tof (matrix-assisted laser desorption ionization time-of-flight) mass spectrometer. The sample plate is usable for the mass spectrometry of a polymeric material on the order of several hundreds of da and a method of manufacturing the same sample plate.
Industry-academic Cooperation Foundation, Yonsei University


05/07/15
20150122990 

Miniature charged particle trap with elongated trapping region for mass spectrometry


A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles..
The University Of North Carolina Of Chapel Hill


05/07/15
20150122987 

Ion generation using wetted porous material


The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent..
Purdue Research Foundation


04/30/15
20150115150 

Kisspeptin-54 detection by tandem mass spectrometry


Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques..
Quest Diagnostics Investments Inc.


04/23/15
20150111134 

Mask blank and manufacturing a transfer mask


Provided is a mask blank having a structure including a thin film on a substrate, wherein the thin film is made of a material containing one or more elements selected from tantalum, tungsten, zirconium, hafnium, vanadium, niobium, nickel, titanium, palladium, molybdenum, and silicon, and wherein the normalized secondary ion intensity of at least one or more ions selected from a calcium fluoride ion, a magnesium fluoride ion, an aluminum fluoride ion, a calcium chloride ion, and a magnesium chloride ion is 2.0×10−4 or less when a surface of the thin film is measured by time-of-flight secondary ion mass spectrometry (tof-sims) under measurement conditions of a primary ion species of bi3++, a primary accelerating voltage of 30 kv, and a primary ion current of 3.0 na.. .
Hoya Corporation


04/23/15
20150108341 

Mass spectrometer and mass spectrometry


A portable mass spectrometer that is carried to a sampling site to conduct analysis incorporates measures against erroneous operation. To prevent erroneous operation, when a measurement sample cannot be accurately analyzed because of contamination in the measurement sample, a criterion for aborting the sample measurement is provided and mass spectrometer control maintenance is performed.
Hitachi High-technologies Corporation


04/16/15
20150106028 

Characterization of crude oil by fourier transform ion cyclotron resonance mass spectrometry


A system, method and computer program product are provided for calculating the cetane number, octane number, pour point, cloud point and aniline point of crude oil fractions from the density and fourier transform ion cyclotron resonance mass spectrometry (ft-icr ms) of a sample of the crude oil.. .

04/16/15
20150105292 

Method for analysis of compound-binding ability of protein


A method for analyzing a binding ability of protein to a compound, involves fractionating first and second groups of proteins into plural fractions using a carrier having the compound immobilized thereon; combining fractions, analyzing the combined fractions with mass spectrometry; based on the mass spectrometry information, obtaining, regarding each fraction, an intensity ratio between peaks derived from a protein in each of the groups of fractions; and comparing degrees of the binding ability of the plural kinds of proteins to the compound.. .
Eisai R&d Management Co.,


04/09/15
20150099669 

Mass spectrometry imaging of glycans from tissue sections and improved analyte detection methods


The presently disclosed subject matter provides methods using mass spectrometry for direct profiling of n-linked glycans from a biological sample. In addition, the embodiments of the present invention also disclose novel methods, known as targeted analyte detection (tad), for improving the detection limit of maldi-ms.
The Johns Hopkins University


04/09/15
20150096349 

Optimize analyte dynamic range in gas chromatography


A non-specific gas analyzer with a wide dynamic range of concentration is used to assess the gas sample for total load of volatile organic constituents, and then control either a dilution with neutral gas or the quantity of sample aspirated in order to consistently deliver an appropriate total load of volatile analyte to a high-sensitivity analyzer. Such high-sensitivity analyzers may be gas chromatography combined with mass spectrometry or related mass spectrometry configurations, such as selected ion flow tube mass spectrometry, gas chromatography combined with ion mobility spectrometry, or related ion mobility configurations such as differential mobility spectrometry..
Pen Inc.


04/02/15
20150093780 

Preparation of thin tissue sections for imaging mass spectrometry


The invention relates to the preparation of thin tissue sections for mass spectrometric (maldi) imaging, and proposes a method wherein a microcrystalline layer of the matrix material is produced on the surface of the thin tissue sections, and soluble analyte molecules are transported orthogonally through the thin tissue section to the matrix layer, without substantial lateral diffusion, by means of a solvent flow with alternating or constant direction, and are then deposited in the matrix layer and, if possible, embedded in the matrix crystals. A solvent flow which alternates in direction can be produced by successive, alternating phases of swelling and drying, brought about by periodic changes to the thin tissue section temperature and/or the partial pressures of the solvents.
Bruker Daltonik Gmbh


04/02/15
20150090875 

Method of ms mass spectrometry


A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are analysed and a second mode in which parent ions are fragmented and their fragment ions are mass analysed. In the first mode the parent ions are charge reduced before being analysed, so as to simplify the parent ion spectral data obtained.
Micromass Uk Limited


04/02/15
20150090874 

Method and apparatus to provide parallel acquisition of mass spectrometry/mass spectrometry data


A system and method for acquisition of mass spectrometry data is configured to provide a stream of charged particles (e.g., from an analytical volume). A primary mass spectrometer (e.g., time-of-flight mass spectrometer) may be used to separate charged particles of the stream of charged particles based on their mass-to-charge ratio and detect the charged particles in a mass-to-charge spectrum.
Ulvac-phi, Incorporated


04/02/15
20150090873 

Method of single point internal lock-mobility correction


A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g.
Micromass Uk Limited


03/26/15
20150087073 

Methods for quantifying polypeptides using mass spectrometry


A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of comprising an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent comprising an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent comprising an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole..
Waters Technologies Corporation


03/26/15
20150084048 

Bottom gate type thin film transistor, manufacturing the same, and display apparatus


Provided is a bottom gate type thin film transistor including on a substrate (1) a gate electrode (2), a first insulating film (3) as a gate insulating film, an oxide semiconductor layer (4) as a channel layer, a second insulating film (5) as a protective layer, a source electrode (6), and a drain electrode (7), in which the oxide semiconductor layer (4) includes an oxide including at least one selected from the group consisting of in, zn, and sn, and the second insulating film (5) includes an amorphous oxide insulator formed so as to be in contact with the oxide semiconductor layer (4) and contains therein 3.8×1019 molecules/cm3 or more of a desorbed gas observed as oxygen by temperature programmed desorption mass spectrometry.. .
Canon Kabushiki Kaisha


03/19/15
20150080233 

Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry


A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (sims) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set.
The Board Of Trustees Of The Leland Stanford Junior University


03/19/15
20150079502 

Mask blank and manufacturing a transfer mask


Provided is a mask blank having a structure including a thin film on a substrate, wherein the thin film is made of a material containing one or more elements selected from tantalum, tungsten, zirconium, hafnium, vanadium, niobium, nickel, titanium, palladium, molybdenum, and silicon, and wherein the normalized secondary ion intensity of at least one or more ions selected from a calcium ion, a magnesium ion, and an aluminum ion is 1.0×10−3 or less when a surface of the thin film is measured by time-of-flight secondary ion mass spectrometry (tof-sims) under measurement conditions of a primary ion species of bi3++, a primary accelerating voltage of 30 kv, and a primary ion current of 3.0 na.. .
Hoya Corporation


03/19/15
20150076341 

Method of mass spectrometry and a mass spectrometer


The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas..
Micromass Uk Limited


03/19/15
20150076340 

Mass spectrometric analysis using nanoparticle matrices


Methods of characterizing an analyte of interest are provided. The methods can involve using a population of nanoparticles (e.g., magnetic ferrite nanoparticles) as a matrix for matrix-assisted laser desorption ionization (maldi) mass spectrometry.
The Board Of Trustees Of The University Of Alabama


03/12/15
20150073727 

Method and improved quantitation by mass spectrometry


A method of quantifying analytes from mass spectral data, comprising: obtaining a first set of mass spectral data from a first set of analytes eluted from a chromatography column; obtaining a second set of mass spectral data from a second set of analytes eluted from a chromatography column; determining apparent abundances of analytes in each data set; selecting a target analyte and determining localised neighboring analytes by their locality to the target analyte with respect to retention time; determining a locally corrected abundance of the target analyte based on differences between the first and second data sets in the apparent abundance of the localised neighboring analytes; and quantifying the target analyte based on its corrected abundance. A majority of the neighboring analytes are typically substantially unchanged in actual abundance between the first and second data sets and can be used for aligning the abundances between the data sets..
Thermo Fisher Scientific (breman) Gmbh


03/12/15
20150072895 

Srm/mrm assay for subtyping lung histology


The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins that are particularly advantageous for quantifying the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


03/12/15
20150069226 

Mass spectrometry phosphorylated peptides and sugar chains


The present invention provides a method for mass spectrometry of phosphorylated peptides or sugar chains, which suppresses the desorption of an unstable site during ionization and achieves high sensitivity (i.e., detects molecular-related ions at a high ionic strength and at a relatively higher ionic strength than other ion species derived from the desorption of an unstable site). A method for mass spectrometry of phosphorylated peptides or sugar chains, the method comprising using, as a liquid matrix, an ionic liquid comprising a 3-aminoquinoline ion and a p-coumaric acid ion.
Shimadzu Corporation


03/05/15
20150066421 

Method for following degassing rate by measuring partial pressures measured bymass spectrometry


Where m denotes the set of reference atomic masses, pi denotes the partial pressures for the atomic masses measured by the mass spectrometer, the coefficients αi denote preset weighting coefficients associated with each partial pressure pi, and n denotes a maximum atomic mass for which the partial pressure pi can be measured by the mass spectrometer.. .

03/05/15
20150064739 

Analyzer


An analyzer includes a pretreatment device and a mass spectrometer. The pretreatment device includes a solid phase extraction mechanism.
Hitachi High-technologies Corporation


03/05/15
20150060659 

Vitamin b2 detection by mass spectrometry


Methods are described for measuring the amount of a vitamin b2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin b2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques..
Quest Diagnostics Investments Inc.


03/05/15
20150060657 

Ms/ms analysis using ecd or etd fragmentation


A method of mass spectrometry is disclosed comprising providing a mixture of different analyte ions and supplying electrons or reagent ions to said mixture so as to transfer charge to the analyte ions. The transfer of charge causes at least some of the analyte ions to dissociate and others of the analyte ions not to dissociate, but to form intermediate ions of altered charge state.
Micromass Uk Limited


03/05/15
20150060656 

Ion deflection in time-of-flight mass spectrometry


A time-of-flight mass spectrometry (tof ms) system includes an ion deflector, ion extractor, a flight tube, and a detector. The deflector may be disposed in the flight tube or outside the flight tube upstream of the extractor.
Agilent Technologies, Inc.


02/26/15
20150056708 

Methods for detecting estrone by mass spectrometry


Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample..
Quest Diagnostics Investments, Inc.


02/26/15
20150053854 

Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum


Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry..
Wayne State University


02/26/15
20150053853 

Plume collimation for laser ablation electrospray ionization mass spectrometry


In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume.
The George Washington University




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Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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