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Mass Spectrometry patents

      

This page is updated frequently with new Mass Spectrometry-related patent applications.




new patent Mass spectrometry polypeptides
Provided is a method for measuring a target polypeptide in a biological sample abundantly containing impurities by mass spectrometry. A method for measuring a target polypeptide in a biological sample includes: a first reaction step of bringing a liquid containing a biological sample into contact with a first antibody-immobilizing carrier to bind the target polypeptide in the biological sample with the first carrier; a first washing step of washing the first carrier; a first eluting step of eluting the target polypeptide from the first carrier by using an acidic solution to obtain a first eluate; a neutralizing step of obtaining a first purified solution by adding a neutral buffer to the first eluate; a second reaction step of bringing the first purified solution into contact with a second antibody-immobilizing carrier, to bind the target polypeptide in the first purified solution with the second carrier; a second washing step of washing the second carrier; a second eluting step of eluting the target polypeptide from the second carrier by using an acidic solution to obtain a second purified solution; and a step of detecting the target polypeptide in the second purified solution by mass spectrometry..
Shimadzu Corporation


new patent Studies on real time ozone layer depletion monitoring using the negative ion mode of ion mobility spectrometry / atmospheric pressure ionization mass spectrometry (neg. mode ims/apims) in upper and lower atmosphere
The present invention provides a capability of ion mobility spectrometry/atmospheric pressure ionization mass spectrometry (ims/ms) in the negative ion mode for ozone detection and methods for ozone layer depletion monitoring in laboratory environment. Ammonium hydroxide vapors, as a dopant chemical, introduced to the inlet system of the ims/ms interfaced with the reaction sphere enables ozone ionized to be o3−.

Method of optimising spectral data
A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analysing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion.
Micromass Uk Limited


Method and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system
A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (gc-ms) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the gc-ms system, at a location between a high vacuum end of a transfer line and a mass analyzer of the gc-ms system.
Thermo Finnigan Llc


Kinase activity detection methods
The invention provides cellular assays for detecting the activity of one or more kinase from multiple conditions simultaneously, by encoding biochemically identical substrates with isotope labels that enable them to be distinguished in pooled samples by mass spectrometry.. .
Purdue Research Foundation


Ambient infrared laser ablation mass spectrometry (airlab-ms) with plume capture by continuous flow solvent probe
A new experimental setup for spatially resolved ambient infrared laser ablation mass spectrometry (airlab-ms) that uses an infrared microscope with an infinity-corrected reflective objective and a continuous flow solvent probe coupled to a fourier transform ion cyclotron resonance mass spectrometer is described. The efficiency of material transfer from the sample to the electrospray ionization emitter was determined using glycerol/methanol droplets containing 1 mm nicotine and is ˜50%.
The Regents Of The University Of California


Molecular diagnostics in personalized dermatology, dermatopathology and cosmetics
The present disclosure relates generally to methods and apparatus for determining components and associated conditions in a dermatological sample, and preparing personalized cosmetics or treatments. In particular, the present disclosure relates to the use of surface desorption ionization-mass spectrometry methods and apparatus to assay dermatological samples.
Waters Technologies Corporation


Methods and identification of polymeric species from mass spectrometry output
Methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data corresponding to an unidentified chemical compound. By restricting the generation of candidate formulas to those having repeating units and/or end units with specified limitations, the methods and apparatus may more efficiently iteratively search for a chemical formula having matching mass spectrometry output within a threshold tolerance.
Perkinelmer Health Sciences, Inc.


Profile diagnostics in personalized dermatology, dermatopathology and cosmetics
The present disclosure relates generally to methods and apparatus for profiling the components and associated conditions in a dermatological sample, and preparing personalized cosmetics or treatments, in particular, the present disclosure relates to the use of surface desorption ionization-mass spectrometry apparatus and omics methodologies to profile or “fingerprint” dermatological samples, such as skin and hair samples, for personalized cosmetics. In particular, the method and apparatus can allow real time mass spectrometry—based lipidomics and metabolomics to phenotype skin and hair samples for molecular personalized cosmetics..
Waters Technologies Corporation


Method of charge state selection
A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionising the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the ions transmitted by a mass filter are varied as a function of the electrophoretic mobility and according to a predetermined relationship such that substantially only ions having said desired charge state are transmitted by the mass filter..
Micromass Uk Limited


Systems and methods for using interleaving window widths in tandem mass spectrometry

Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.

Systems and methods for acquiring data for mass spectrometry images

Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.

Binary labeling

The present invention relates to a method for allocating information about an object. Moreover, the present invention relates to a method for labeling an object for example a method for tracking or identifying an object containing a predetermined information.
Lumiprobe Gmbh

Mass spectrometry assay for estrogenic compounds

Methods are provided for detecting the amount of one or more hrt panel analytes (i.e., estrone (e1), estrone sulfate (e1s), 17α-estradiol (e2a), 17β-estradiol (e2b), estradiol sulfate (e2s), estriol (e3), equilin (eq), 17α-dihydroequilin (eqa), 17β-dihydroequilin (eqb), equilenin (en), 17α-dihydroequilenin (ena), 17β-dihydroequilenin (enb), and Δ8,9-dehydroestrone (de1)) in a sample by mass spectrometry. The methods generally involve ionizing one or more hrt panel analytes in a sample and quantifying the generated ions to determine the amount of one or more hrt panel analytes in the sample.
Quest Diagnostics Investments Incorporated

Bcl-2-like protein 11 srm/mrm assay

Specific peptides, and derived ionization characteristics of those peptides, from the bcl-2-like protein 11 (bim) are provided that are particularly advantageous for quantifying the bim protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm). Such biological samples are chemically preserved and fixed where the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.

Functionalized biochips for spr-ms coupling

The invention relates to a method for coupling in-line the analysis of molecular interactions by surface plasmon resonance (spr) with a structural identification by mass spectrometry using the same functionalized support for both types of analysis.. .
Universite D'evry Val D'essonne

Systems and methods for using variable mass selection window widths in tandem mass spectrometry

Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.

Ion analyzer

A cloud of ions captured in an ion trap (2) is irradiated with a stream of hydrogen radicals cast through a radical particle introduction hole (26) bored in a ring electrode (21) at a flow rate of 4×1010 [atoms/s]. As a result, a radical induced dissociation which does not rely on the transfer or capture of electrons occurs within the ion trap (2), whereby c/z-type fragment ions are efficiently generated.
Shimadzu Corporation

Personalized myeloma detection

Disclosed herein is a personalized method for monitoring a condition or disorder associated with antibody production in a subject. The method can involve treating a biological sample comprising immunoglobulin from the subject to enzymatically cleave a target immunoglobulin associated with the pcd into one or more variable domain peptide fragments of the target immunoglobulin, and then measuring the one or more variable domain peptide fragments in the sample by quantitative mass spectrometry to quantify the amount of the target immunoglobulin in the sample..
H. Lee Moffitt Cancer Center And Research Institute Inc.

Optimized multiple reaction monitoring or single ion recording method

A method of mass spectrometry is disclosed comprising monitoring for the emergence of one or more species of ions of interest and determining during the course of acquiring experimental data whether one or more ions or interest have emerged and then discontinuing monitoring for the emergence of the one or more species of ions of interest if it determined that the one or more ions or interest have emerged.. .
Micromass Uk Limited

Method for tandem mass spectrometry analysis in ion trap mass analyzer

This invention is related to a tandem mass spectrometric analysis method in ion trap mass analyzer. Such method comprise three stages as represented by selective isolation, collision induced disassociation and mass scanning of ion.
Fudan University

Reducing overfragmentation in ultraviolet photodissociation

A method and apparatus are disclosed for dissociation of precursor ions, such as polypeptides, by ultraviolet photodissociation (uvpd) for mass spectrometry analysis. Precursor ions are confined within an ion trap and irradiated with ultraviolet (uv) light, which may take the form of pulses emitted by a laser.
Thermo Finnigan Llc

Novel diagnostic gastric cancer

This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in n-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the n-glycan as compared to normal persons, n-glycan structures identified using the changes in n-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis..
Korea Advanced Institute Of Science And Technology

Analysis of amino acids in body fluid by liquid chromotography-mass spectrometry

This disclosure provides methods for quantifying individual amino acids in various bodily fluids obtained from a human patient. Also provided are reference ranges for normal amino acid levels in the various bodily fluids (e.g., blood plasma, urine, cerebrospinal fluid, and saliva) and for various age groups (e.g., neonates, infants, children, and adults)..
Quest Diagnostics Investment Inc.

Mass spectrometric determination of fatty acids

The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry..
Quest Diagnostics Investments Incorporated

Method for developing and applying databases for idenfication of microorganisms by maldi-tof mass spectrometry

A method for organism identification using maldi tof mass spectrometry includes generating a searchable database. A mass spectrum is acquired from a sample.
Virgin Instruments Corporation

Compositions and methods for analysis of protein sequences and post-translational modifications

The application discloses, compositions, methods, systems, and apparatuses for rapid sequence analysis of proteins, including location of post-translational modifications and disulfide bonds, is described. Limited digestion of fully denatured antibody occurs in seconds by flowing sample in 8 m urea at constant pressure through a micro column reactor containing immobilized aspergillopepsin i, resulting in a product mixture containing 3-10 kda peptides, which is then fractionated by capillary column chromatography and analyzed by both electron transfer dissociation (etd) and collision activated dissociation mass spectrometry.
University Of Virginia Patent Foundation

Insulin receptor substrate 1 (irs1) protein srm/mrm assay

The current disclosure provides for specific peptides from the insulin receptor substrate 1 (irs1) protein and the derived ionization characteristics of those peptides that are particularly advantageous for quantifying the irs1 directly in formalin fixed biological samples by the method of selected reaction monitoring (srm) mass spectrometry. Such fixed biological samples include: formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and formalin fixed and paraffin embedded tissue culture cells.
Expression Pathology, Inc.

Quantifying her2 protein for optimal cancer therapy

Improved methods of treatment are provided for patients suffering from cancer. The methods identify whether a tumor will be responsive to treatment with a therapeutic regime that includes anti-her2 therapeutic agents.
Expression Pathology, Inc.

Free and total fatty acid determination using desorption ionization - mass spectrometry

The present disclosure relates to methods and apparatus for the determination of free fatty acids and total fatty acids in a sample. In particular, the present disclosure relates to the determination of free fatty acids and total fatty acids using desorption ionization-mass spectrometry.
Waters Technologies Corporation

Methods for mass spectrometric quantitation of analytes extracted from a microsampling device

Mass spectrometric methods are described for determining the amount of analyte in a sample collected by a microsampling device. Provided herein are methods directed to quantitating the amount of an analyte in a sample by extracting an analyte from a sample collected by a microsampling device, purifying the sample by liquid chromatography, ionizing the analyte to generate one or more ions detectable by mass spectrometry; and determining the amount of the one or more ions by mass spectrometry.
Quest Diagnostics Investments Llc

Electrostatic mass spectrometer with encoded frequent pulses

A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
Leco Corporation

Analytical apparatus utilizing electron impact ionization

An analytical apparatus for mass spectrometry comprises an electron impact ionizer including an electron emitter and an ionization target zone. The target zone is arranged to be populated with matter to be ionized for analysis.
Markes International Limited

Coupling device for mass spectrometry apparatus

An object of the present invention is to provide a technology that enables highly sensitive atmospheric-pressure real-time mass spectrometry of a volatile substance. The present invention provides a coupling device for a mass spectrometry apparatus that is an interface member to be connected to an atmospheric-pressure real-time mass spectrometry apparatus, the coupling device including (a) an excitation gas introducing port, a sample gas introducing port, and an ionized sample gas discharging port, (b) a channel through which the excitation gas introducing port and the ionized sample gas discharging port are in communication, and (c) a space for mixing excitation gas and sample gas being formed in a region of a portion of the channel recited in (b), by the coupling device having a structure in which the sample gas introducing port and the channel recited in (b) are in communication..
Biochromato, Inc.

Tandem mass spectrometry data processing system

A composition formula of each precursor ion located on a measured mass spectrum is estimated from the m/z value of the precursor ion (s11). A composition formula of each product ion located on a measured ms/ms spectrum is estimated from the m/z value of the product ion (s11).
Shimadzu Corporation

Tandem mass spectrometry data processing system

Peak information is collected from an ms/ms spectrum in which the product ions generated from ions originating from a plurality of compounds are mixed. Using one of the m/z values of a plurality of ion species as precursor-ion information and the peak information of the ms/ms spectrum as product-ion information, a database search is performed to find candidate compounds for each compound, and a standard ms/ms spectrum of each candidate compound is obtained.
Shimadzu Corporation

Setting ion detector gain using ion area

A control system and method of determining a signal to noise (s/n) ratio of an ion detector system, including an ion detector, electron multiplier or photomultiplier, operates by determining an area of a noise peak, determining an area of a signal peak and determining a ratio of the area of the signal peak to the area of the noise peak. Based thereon, the signal to noise ratio can be optimised.
Micromass Uk Limited

Methods and materials for monitoring myeloma using quantitative mass spectrometry

The subject invention concerns methods and materials for diagnosing, monitoring the progress, and/or providing a prognosis for multiple myeloma and other conditions associated with antibody production in a person or animal. The methods of the invention utilize mass spectrometry for quantitative monitoring and detection of antibody produced by the plasma cells.
H. Lee Moffitt Cancer Center And Research Institute, Inc.

Srm/mrm assay for the cyclin-dependent kinase inhibitor 2a (p16) protein

Methods are provided for quantifying the cyclin-dependent kinase inhibitor 2a protein (p16) p16 protein directly in biological samples that have been fixed in formalin by srm/mrm mass spectrometry. A protein sample is prepared from the biological sample using, for example, the liquid tissue reagents and protocol and the p16 protein is quantitated in the resulting sample by quantitating in the protein sample at least one fragment peptide from p16.
Expression Pathology, Inc.

System and analyzing tissue intra-operatively using mass spectrometry

A system and method for ample analysis including acquiring a tissue sample, preparing the tissue sample for mass spectrometry imaging, conducting a mass spectrometry procedure on the tissue sample to produce an image, analyzing the image to determine the presence or absence of a biomarker; and generating a report indicating a presence or absence of cancer.. .
Brigham And Women's Hospital, Inc.

A single reactor for simplified sample preparation workflows

This disclosure provides a single reactor that accommodates an affinity selector to separate analytes of interest, and an enzyme reactor that digest the analyte to suitable peptides for mass spectrometry. The single reactor formats described herein accommodate workflows wherein separation precedes digestion as well as workflows wherein digestion precedes separation selection..
Perfinity Biosciences, Inc.

Multiplexed electrostatic linear ion trap

Systems and methods are provided for performing multiplex electrostatic linear ion trap mass spectrometry. A first beam of ions is received and the first beam is split into n beams of ions using a beam splitter.
Dh Technologies Development Ptd. Ltd.

Ion guide for mass spectrometry

Methods and systems for transmitting ions in an ion guide are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can cause at least a portion of ions entrained in a gas flow entering an ion guide to be extracted from the gas jet and be guided downstream along one or more path of gas flow, where the gas lacking the ions can be removed from the ion guide.
Dh Technologies Development Pte. Ltd.

Srm/mrm assay for the fibroblast growth factor receptor 2 (fgfr2) protein

Methods are provided for quantifying the fibroblast growth factor receptor 2 protein (fgfr2) directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm)/multiple reaction monitoring (mrm) mass spectrometry. The biological sample may be selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells.
Expression Pathology, Inc.

Srm/mrm assay for the mesothelin (msln) protein

Methods are provided for detecting and quantifying the mesothelin protein (msln) in biological samples that have been fixed in formalin using selected reaction monitoring (srm)/multiple reaction monitoring (mrm) mass spectrometry. The biological sample may be, for example, tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.

Formalin-fixed isotope-labeled reference standards and methods for fabrication and use thereof

One or more cells are labeled with minor stable isotopes, characterized, and preserved for subsequent use as a bio-specimen reference standard. The one or more cells are grown in culture media supplied with minor stable isotopes in concentrations substantially different from normally occurring concentrations, thereby supplanting major stable isotopes that would normally be incorporated into the proteins of the cells.
Bioproximity, Llc

Srm/mrm assay for the 6-o-methylguanine-dna methyltransferase (mgmt) protein

The current disclosure provides methods for detecting and quantitating the 6-o-methylguanine-dna methyltransferase protein (mgmt) directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed with formaldehyde containing agents/fixatives and may include formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and/or paraffin embedded.
Expression Pathology, Inc.



Mass Spectrometry topics:
  • Mass Spectrometry
  • Spectrometry
  • Spectrometer
  • Mass Spectrometer
  • Chromatograph
  • Extrapolate
  • Hydrocarbon
  • High Resolution
  • Chromatography
  • Quantitative
  • Drug Resistance
  • Phosphorylation
  • Peptide Sequence
  • Formaldehyde
  • Amino Acid


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    This listing is a sample listing of patent applications related to Mass Spectrometry for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mass Spectrometry with additional patents listed. Browse our RSS directory or Search for other possible listings.


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