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Mass Spectrometry patents



      
           
This page is updated frequently with new Mass Spectrometry-related patent applications. Subscribe to the Mass Spectrometry RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometry RSS RSS


National Sun Yat-sen University

Multiple solid phase micro-extraction thermal desorption ionization device, mass spectrometer and analytical method for…

Date/App# patent app List of recent Mass Spectrometry-related patents
05/28/15
20150148260
 Analyte mass spectrometry quantitation using a universal reporter patent thumbnailnew patent Analyte mass spectrometry quantitation using a universal reporter
Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.. .
05/28/15
20150147776
 Mass spectrometry analysis of microorganisms in samples patent thumbnailnew patent Mass spectrometry analysis of microorganisms in samples
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
Purdue Research Foundation
05/28/15
20150144783
 Glycopeptide analyzer patent thumbnailnew patent Glycopeptide analyzer
The same sample s is analyzed using an ion-trap (it) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (tof) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an it mass spectrum and a tof mass spectrum from the measured results.
Shimadzu Corporation
05/28/15
20150144780
 Method of ms/ms mass spectrometry patent thumbnailnew patent Method of ms/ms mass spectrometry
A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to electron capture dissociation (“ecd”) at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected.
Micromass Uk Limited
05/28/15
20150144777
 Multiple solid phase micro-extraction thermal desorption ionization device, mass spectrometer and analytical  mass spectrometry patent thumbnailnew patent Multiple solid phase micro-extraction thermal desorption ionization device, mass spectrometer and analytical mass spectrometry
A multiple solid phase microextraction (m-spme) thermal desorption ionization device which desorbs an analyte and moves it into an entry of a mass spectrometer for mass spectrometry analysis is provided. The device has a charge producing unit, a heating unit and a sampling unit.
National Sun Yat-sen University
05/21/15
20150140600
 Mass spectrometry quantitation of p450 isoforms in hepatocytes patent thumbnailMass spectrometry quantitation of p450 isoforms in hepatocytes
A method for screening a drug for cytochrome p450 (cyp) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome p450 isoform. The isoforms can be selected from 2b6, 3a4, 1a2, and 3a5 isoforms.
Dh Technologies Development Pte. Ltd.
05/21/15
20150140593
 Retention index standards for liquid chromatography patent thumbnailRetention index standards for liquid chromatography
A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (lc-ms) methods, more especially for lc-ms methods employing electrospray (esi) or atmospheric pressure chemical ionization (apci) ionization systems.. .
National Research Council Of Canada
05/21/15
20150136973
 Pulsed ion beam source for electrospray mass spectrometry patent thumbnailPulsed ion beam source for electrospray mass spectrometry
Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry.
Academia Sinica
05/21/15
20150136972
 Analysis of microbes by maldi mass spectrometry patent thumbnailAnalysis of microbes by maldi mass spectrometry
The invention relates to methods for the mass spectrometric analysis of microbes, in particular to a transfer method of microbes that are required to be identified from agar plates onto mass spectrometric sample supports and their preparation for ionization by matrix-assisted laser desorption (maldi). Microbes from microcolonies which have grown on the agar plates after a culture time of only six to eight hours are transferred with a high transfer yield onto contact surfaces of suitable size by direct contact and cell disrupted on the contact surface; the released proteins are prepared with matrix material on the contact surface as maldi samples.
Bruker Daltonik Gmbh
05/21/15
20150136969
 Method of identifying precursor ions patent thumbnailMethod of identifying precursor ions
A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analysing the fragment or product ions; determining the start and end times at which a first fragment or product ion is detected; using said start and end times to determine the start and end times at which a precursor ion of said first fragment or product ion is transmitted by said mass analyser; and using the start and end times at which the precursor ion is transmitted by said mass analyser to determine a mass to charge ratio of said precursor ion. The present invention enables precursor ion peaks to be resolved from the fragment data even when a low resolution mass analyser is used to analyse the precursor ions..
Micromass Uk Limited
05/21/15
20150136968

Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.
05/14/15
20150133342

Mrm-ms signature assay


The present invention relates to mass spectrometry methods employing multiple reaction monitoring (mrm) in the field of cancer therapeutics, specifically prostate cancer and melanoma.. .
05/14/15
20150132854

Tuned synthetic dendrimer calibrants for mass spectrometry


Provided are synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative ease and rapidity of synthesis, comparatively low cost, long shelf life, high purity, and amenability to batch synthesis as mixtures.
05/14/15
20150130810

Mass spectrometry data processing device


A data processing device in which, on a screen where an ms spectrum for a retention time designated by the analyst is displayed in the upper area and an ms2 spectrum for a precursor ion selected automatically based on the ms spectrum is displayed in the lower area, when an “on” button in a precursor parameter display selection frame in the top part is clicked, excluded ion and priority ion information for that retention time is collected and the m/z ranges and are displayed in a specified display color on the ms spectrum. As a result, it becomes possible to see at a glance whether the precursor ion indicated by upward arrow corresponds to an excluded ion or priority ion..
05/14/15
20150129762

Reducing interferences in isobaric tag-based quantification


Methods and systems for performing mass spectrometry of analytes labeled with isobaric tags are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can enable enhanced discrimination between an analyte of interest and one or more interfering species when using isobaric tagging techniques..
05/14/15
20150129761

Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy


The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion.. .
05/14/15
20150129758

Systems and methods for sequencing peptides by mass spectrometry


The number of atoms present in an ion of a molecule is identified using a mixture of different forms of the molecule. A mass spectrometer analyzes a mixture of at least two forms of the molecule using one or more ion scans producing a mass spectrum.
05/14/15
20150129757

Systems and methods for using variable mass selection window widths in tandem mass spectrometry


Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
05/07/15
20150126406

Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor


Disclosed herein are isobaric labeling reagent sets useful for multiplexed quantitation of peptides. The isobaric labeling reagent sets include a collection of at least two isobaric labeling reagents having first and second reporter groups with the same nominal mass but different isotopic substitutions and consequently different exact masses.
Thermo Finnigan Llc
05/07/15
20150126384

Prognostic biomarkers in patients with ovarian cancer


The present invention provides methods for assessing an ovarian cancer patient's survival status. Also, methods for evaluating the ovarian cancer state of a patient are described herein.
Vermillion, Inc.
05/07/15
20150125877

Weak affinity chromatography


The present invention provides methods for analyzing a target compound from a biological sample. In one aspect, a method for analyzing a target compound in a biological sample can comprise delivering a biological sample through an affinity column, the affinity column having a binding ligand coupled to a stationary structural support, wherein the affinity column has a high density of the binding ligand per the stationary structural support and wherein the binding ligand has been preselected to cause weak affinity separation zonal retardation of the target compound from the biological sample forming a target compound fraction and a biological sample fraction and detecting the target compound by mass spectrometry..
05/07/15
20150123825

Techniques for compressing mass spectrometry data in real-time


Techniques are described for performing data compression of a first data set including data points in a plurality of dimensions. First processing is performed to determine a second set of final sums.
Waters Technologies Corporation
05/07/15
20150123012

Sample plate using maldi-tof mass spectrometer and manufacturing the sample plate


A sample plate in use with a maldi-tof (matrix-assisted laser desorption ionization time-of-flight) mass spectrometer. The sample plate is usable for the mass spectrometry of a polymeric material on the order of several hundreds of da and a method of manufacturing the same sample plate.
Industry-academic Cooperation Foundation, Yonsei University
05/07/15
20150122990

Miniature charged particle trap with elongated trapping region for mass spectrometry


A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles..
The University Of North Carolina Of Chapel Hill
05/07/15
20150122987

Ion generation using wetted porous material


The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent..
Purdue Research Foundation
04/30/15
20150115150

Kisspeptin-54 detection by tandem mass spectrometry


Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques..
Quest Diagnostics Investments Inc.
04/23/15
20150111134

Mask blank and manufacturing a transfer mask


Provided is a mask blank having a structure including a thin film on a substrate, wherein the thin film is made of a material containing one or more elements selected from tantalum, tungsten, zirconium, hafnium, vanadium, niobium, nickel, titanium, palladium, molybdenum, and silicon, and wherein the normalized secondary ion intensity of at least one or more ions selected from a calcium fluoride ion, a magnesium fluoride ion, an aluminum fluoride ion, a calcium chloride ion, and a magnesium chloride ion is 2.0×10−4 or less when a surface of the thin film is measured by time-of-flight secondary ion mass spectrometry (tof-sims) under measurement conditions of a primary ion species of bi3++, a primary accelerating voltage of 30 kv, and a primary ion current of 3.0 na.. .
Hoya Corporation
04/23/15
20150108341

Mass spectrometer and mass spectrometry


A portable mass spectrometer that is carried to a sampling site to conduct analysis incorporates measures against erroneous operation. To prevent erroneous operation, when a measurement sample cannot be accurately analyzed because of contamination in the measurement sample, a criterion for aborting the sample measurement is provided and mass spectrometer control maintenance is performed.
Hitachi High-technologies Corporation
04/16/15
20150106028

Characterization of crude oil by fourier transform ion cyclotron resonance mass spectrometry


A system, method and computer program product are provided for calculating the cetane number, octane number, pour point, cloud point and aniline point of crude oil fractions from the density and fourier transform ion cyclotron resonance mass spectrometry (ft-icr ms) of a sample of the crude oil.. .
04/16/15
20150105292

Method for analysis of compound-binding ability of protein


A method for analyzing a binding ability of protein to a compound, involves fractionating first and second groups of proteins into plural fractions using a carrier having the compound immobilized thereon; combining fractions, analyzing the combined fractions with mass spectrometry; based on the mass spectrometry information, obtaining, regarding each fraction, an intensity ratio between peaks derived from a protein in each of the groups of fractions; and comparing degrees of the binding ability of the plural kinds of proteins to the compound.. .
Eisai R&d Management Co.,
04/09/15
20150099669

Mass spectrometry imaging of glycans from tissue sections and improved analyte detection methods


The presently disclosed subject matter provides methods using mass spectrometry for direct profiling of n-linked glycans from a biological sample. In addition, the embodiments of the present invention also disclose novel methods, known as targeted analyte detection (tad), for improving the detection limit of maldi-ms.
The Johns Hopkins University
04/09/15
20150096349

Optimize analyte dynamic range in gas chromatography


A non-specific gas analyzer with a wide dynamic range of concentration is used to assess the gas sample for total load of volatile organic constituents, and then control either a dilution with neutral gas or the quantity of sample aspirated in order to consistently deliver an appropriate total load of volatile analyte to a high-sensitivity analyzer. Such high-sensitivity analyzers may be gas chromatography combined with mass spectrometry or related mass spectrometry configurations, such as selected ion flow tube mass spectrometry, gas chromatography combined with ion mobility spectrometry, or related ion mobility configurations such as differential mobility spectrometry..
Pen Inc.
04/02/15
20150093780

Preparation of thin tissue sections for imaging mass spectrometry


The invention relates to the preparation of thin tissue sections for mass spectrometric (maldi) imaging, and proposes a method wherein a microcrystalline layer of the matrix material is produced on the surface of the thin tissue sections, and soluble analyte molecules are transported orthogonally through the thin tissue section to the matrix layer, without substantial lateral diffusion, by means of a solvent flow with alternating or constant direction, and are then deposited in the matrix layer and, if possible, embedded in the matrix crystals. A solvent flow which alternates in direction can be produced by successive, alternating phases of swelling and drying, brought about by periodic changes to the thin tissue section temperature and/or the partial pressures of the solvents.
Bruker Daltonik Gmbh
04/02/15
20150090875

Method of ms mass spectrometry


A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are analysed and a second mode in which parent ions are fragmented and their fragment ions are mass analysed. In the first mode the parent ions are charge reduced before being analysed, so as to simplify the parent ion spectral data obtained.
Micromass Uk Limited
04/02/15
20150090874

Method and apparatus to provide parallel acquisition of mass spectrometry/mass spectrometry data


A system and method for acquisition of mass spectrometry data is configured to provide a stream of charged particles (e.g., from an analytical volume). A primary mass spectrometer (e.g., time-of-flight mass spectrometer) may be used to separate charged particles of the stream of charged particles based on their mass-to-charge ratio and detect the charged particles in a mass-to-charge spectrum.
Ulvac-phi, Incorporated
04/02/15
20150090873

Method of single point internal lock-mobility correction


A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g.
Micromass Uk Limited
03/26/15
20150087073

Methods for quantifying polypeptides using mass spectrometry


A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of comprising an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent comprising an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent comprising an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole..
Waters Technologies Corporation
03/26/15
20150084048

Bottom gate type thin film transistor, manufacturing the same, and display apparatus


Provided is a bottom gate type thin film transistor including on a substrate (1) a gate electrode (2), a first insulating film (3) as a gate insulating film, an oxide semiconductor layer (4) as a channel layer, a second insulating film (5) as a protective layer, a source electrode (6), and a drain electrode (7), in which the oxide semiconductor layer (4) includes an oxide including at least one selected from the group consisting of in, zn, and sn, and the second insulating film (5) includes an amorphous oxide insulator formed so as to be in contact with the oxide semiconductor layer (4) and contains therein 3.8×1019 molecules/cm3 or more of a desorbed gas observed as oxygen by temperature programmed desorption mass spectrometry.. .
Canon Kabushiki Kaisha
03/19/15
20150080233

Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry


A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (sims) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set.
The Board Of Trustees Of The Leland Stanford Junior University
03/19/15
20150079502

Mask blank and manufacturing a transfer mask


Provided is a mask blank having a structure including a thin film on a substrate, wherein the thin film is made of a material containing one or more elements selected from tantalum, tungsten, zirconium, hafnium, vanadium, niobium, nickel, titanium, palladium, molybdenum, and silicon, and wherein the normalized secondary ion intensity of at least one or more ions selected from a calcium ion, a magnesium ion, and an aluminum ion is 1.0×10−3 or less when a surface of the thin film is measured by time-of-flight secondary ion mass spectrometry (tof-sims) under measurement conditions of a primary ion species of bi3++, a primary accelerating voltage of 30 kv, and a primary ion current of 3.0 na.. .
Hoya Corporation
03/19/15
20150076341

Method of mass spectrometry and a mass spectrometer


The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas..
Micromass Uk Limited
03/19/15
20150076340

Mass spectrometric analysis using nanoparticle matrices


Methods of characterizing an analyte of interest are provided. The methods can involve using a population of nanoparticles (e.g., magnetic ferrite nanoparticles) as a matrix for matrix-assisted laser desorption ionization (maldi) mass spectrometry.
The Board Of Trustees Of The University Of Alabama
03/12/15
20150073727

Method and improved quantitation by mass spectrometry


A method of quantifying analytes from mass spectral data, comprising: obtaining a first set of mass spectral data from a first set of analytes eluted from a chromatography column; obtaining a second set of mass spectral data from a second set of analytes eluted from a chromatography column; determining apparent abundances of analytes in each data set; selecting a target analyte and determining localised neighboring analytes by their locality to the target analyte with respect to retention time; determining a locally corrected abundance of the target analyte based on differences between the first and second data sets in the apparent abundance of the localised neighboring analytes; and quantifying the target analyte based on its corrected abundance. A majority of the neighboring analytes are typically substantially unchanged in actual abundance between the first and second data sets and can be used for aligning the abundances between the data sets..
Thermo Fisher Scientific (breman) Gmbh
03/12/15
20150072895

Srm/mrm assay for subtyping lung histology


The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins that are particularly advantageous for quantifying the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.
03/12/15
20150069226

Mass spectrometry phosphorylated peptides and sugar chains


The present invention provides a method for mass spectrometry of phosphorylated peptides or sugar chains, which suppresses the desorption of an unstable site during ionization and achieves high sensitivity (i.e., detects molecular-related ions at a high ionic strength and at a relatively higher ionic strength than other ion species derived from the desorption of an unstable site). A method for mass spectrometry of phosphorylated peptides or sugar chains, the method comprising using, as a liquid matrix, an ionic liquid comprising a 3-aminoquinoline ion and a p-coumaric acid ion.
Shimadzu Corporation
03/05/15
20150066421

Method for following degassing rate by measuring partial pressures measured bymass spectrometry


Where m denotes the set of reference atomic masses, pi denotes the partial pressures for the atomic masses measured by the mass spectrometer, the coefficients αi denote preset weighting coefficients associated with each partial pressure pi, and n denotes a maximum atomic mass for which the partial pressure pi can be measured by the mass spectrometer.. .
03/05/15
20150064739

Analyzer


An analyzer includes a pretreatment device and a mass spectrometer. The pretreatment device includes a solid phase extraction mechanism.
Hitachi High-technologies Corporation
03/05/15
20150060659

Vitamin b2 detection by mass spectrometry


Methods are described for measuring the amount of a vitamin b2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin b2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques..
Quest Diagnostics Investments Inc.
03/05/15
20150060657

Ms/ms analysis using ecd or etd fragmentation


A method of mass spectrometry is disclosed comprising providing a mixture of different analyte ions and supplying electrons or reagent ions to said mixture so as to transfer charge to the analyte ions. The transfer of charge causes at least some of the analyte ions to dissociate and others of the analyte ions not to dissociate, but to form intermediate ions of altered charge state.
Micromass Uk Limited
03/05/15
20150060656

Ion deflection in time-of-flight mass spectrometry


A time-of-flight mass spectrometry (tof ms) system includes an ion deflector, ion extractor, a flight tube, and a detector. The deflector may be disposed in the flight tube or outside the flight tube upstream of the extractor.
Agilent Technologies, Inc.
02/26/15
20150056708

Methods for detecting estrone by mass spectrometry


Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample..
Quest Diagnostics Investments, Inc.
02/26/15
20150053854

Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum


Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry..
Wayne State University
02/26/15
20150053853

Plume collimation for laser ablation electrospray ionization mass spectrometry


In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume.
The George Washington University
02/19/15
20150051283

Composition and inhibition of pkng from mycobacterium tuberculosis


Pkng from mycobacterium tuberculosis is a ser/thr protein kinase that regulates key metabolic processes within the bacterial cell as well as signaling pathways from the infected host cell. This multi-domain protein has a conserved canonical kinase domain with n- and c-terminal flanking regions of unclear functional roles.
Complexa, Inc.
02/19/15
20150051111

Analysis of estradiol and analytes with phenolic oh using labeling chemistry and lc-msms workflow


A method is described for mass spectrometric analysis of a sample comprising phenolic oh, such as a steroid comprising a phenolic oh, using a quaternary amino oxy cookson (qaoc) reagent. The qaoc reagent can improve ionization and fragmentation properties of phenolic oh samples, which can thereby improve quantitation and identification.
Dh Technologies Development Pte. Ltd.
02/12/15
20150045256

Mass spectrometry quantitation of p450 protein isoforms in hepatocytes


A method for screening a drug for cytochrome p450 (cyp) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome p450 isoform. The isoforms can be selected from 2b6, 3a4, 1a2, and 3a5 isoforms.
Dh Technologies Development Pte. Ltd.
02/12/15
20150044713

Method


The present invention provides a method of quantifying the activity of a protein modifying enzyme in a sample, comprising: (i) grouping modified peptides from a first sample and modified peptides from a second sample into a single group according to one of the following parameters: (a) modified peptides having a modification site that is modified by the same protein modifying enzyme; or (b) modified peptides having a modification site that is part of the same modification motif; (ii) calculating enrichment of the modified peptides from the first sample compared to the modified peptides from the second sample in the group; and (iii) calculating the statistical significance of said enrichment; wherein a statistically significant enrichment is indicative of a protein modifying enzyme being activated in the first sample compared to the second sample. In some embodiments, the method further comprises identifying modified peptides in a first sample and a second sample using mass spectrometry (ms) prior to step (i)..
Queen Mary University Of London
02/12/15
20150044708

Methods for detecting oncofetal fibronectin


Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided.
Hologic, Inc.
02/12/15
20150041640

Multi-pole ion trap for mass spectrometry


An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface.
The Rockefeller University
02/12/15
20150041635

Time of flight quantitation using alternative characteristic ions


A method of mass spectrometry is disclosed wherein the intensity of an analyte is determined by determining the intensity of first characteristic fragment ions when the intensity of the first characteristic fragment ions is within a first intensity range corresponding to the detection or unsaturated range of an ion detector. However, when the intensity of the first characteristic fragment ions is outside of the first intensity range so that the ion detector would saturate then the intensity of the analyte is determined by determining the intensity of second different characteristic fragment ions..
Micromass Uk Limited
02/12/15
20150041634

Characterization and prediction of jet fuel quality


Systems and methods are provided for characterizing kerosene fractions in order to determine whether the fractions will satisfy a desired thermal breakpoint specification. Additionally, hydrotreating conditions can be determined that will result in a hydrotreated kerosene fraction that satisfies the desired thermal breakpoint specification.
Exxonmobil Research And Engineering Company
02/05/15
20150037828

Metal organic polymer matrices and systems for chemical and biochemical mass spectrometry and methods of use thereof


Aspects of the disclosure include methods for analyzing an analyte composition by mass spectrometry employing a macroporous metal organic polymer matrix. In practicing methods according to certain embodiments an analyte composition is applied to a macroporous metal organic polymer matrix, a voltage is applied to the macroporous metal organic polymer matrix sufficient to produce and expel analyte ions from the macroporous metal organic polymer matrix and the analyte ions are analyzed by mass spectrometry.
The Board Of Trustees Of The Leland Stanford Junior University
02/05/15
20150034817

Ionization device, mass spectrometry apparatus, mass spectrometry method, and imaging system


A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions.. .
Canon Kabushiki Kaisha
02/05/15
20150034816

Interface for mass spectrometry apparatus


There is provided an interface for use in sampling ions in a mass spectrometer, the interface being arranged for receiving a quantity of ions from an ion source and forming more than one ion beam therefrom, each ion beam being directed along a respective desired pathway.. .
Bruker Chemical Analysis Bv
02/05/15
20150034815

Method for mass spectrometry


A method is provided for mass spectrometry. The method includes generating precursor ions from a sample; transmitting the precursor ions into a collision cell; generating product ions in the collision cell; detecting the precursor and product ions; applying modulation to one or more of the precursor ion intensity and the product ion intensity; and identifying precursor ion and product ion relationships by analyzing intensity profiles defined by the modulation..
Dh Technologies Development Pte. Ltd.


Popular terms: [SEARCH]

Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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This listing is a sample listing of patent applications related to Mass Spectrometry for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mass Spectrometry with additional patents listed. Browse our RSS directory or Search for other possible listings.
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