|| List of recent Mass Spectrometry-related patents
| Computerized method for correlating and elucidating chemical structures and substructures using mass spectrometry|
The present invention is directed to a computational method for correlating and elucidating a mass spectrum with one or more proposed chemical structures.. .
| Selective detection and analysis of small molecules|
The invention relates to a material, process and method for the selective analysis of small molecules. Particularly the invention provides a material and a technique for the analysis of small molecules excluding other large molecular weight (mw) analytes.
| Mass spectrometer|
Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer..
| Sample analysis method and analyzer|
Provided is a sample analysis method of irradiating a sample with a primary ion beam to analyze a secondary ion emitted from the sample by mass spectrometry, the sample analysis method including the steps of cooling a sample placed in a chamber; forming an ice layer on a surface of the cooled sample by discharging one of water and an aqueous solution to the chamber; and irradiating the surface of the sample with the primary ion beam with the ice layer being formed thereon, wherein an amount of the water forming the ice. .
| Deep-maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof|
A method of analyzing a biological sample, for example serum or other blood-based samples, using a maldi-tof mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a maldi-tof sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument.
| Leakage current sense circuit for error detection in an improved capillary electrophoresis-electrospray ionization- mass spectrometry system|
Aspects of the present innovations relate to improved systems that may perform capillary electrophoresis (ce) and ce in conjunction with electrospray ionization (esi) as an input to a mass spectrometry system (ms). Embodiments may use a current sense circuit at a high voltage output from an ms-esi power supply in conjunction with additional elements to identify fault conditions associated with leakage current, to confirm the continuity of ce connections, and to provide improved system protection..
|Method of deadtime correction in mass spectrometry|
A method of improving the fidelity of m/z dependent measurements for a species of interest in an analyte in a mass spectrometer, which method comprises the steps of acquiring raw data produced in a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent measurements with associated uncertainties.. .
|Rapid and high-throughput analysis of sterols/stanols or derivatives thereof|
This invention relates to a rapid, high-throughput process for analyzing one or more sterols/stanols or derivatives thereof in a plurality of samples. The method comprises the steps of introducing a plurality of samples containing one or more sterols/stanols or derivatives thereof into individual vessels in a multi-vessel plate; cleaving the one or more sterols/stanols or derivatives thereof of each sample in the multi-vessel plate to form free sterols/stanols; extracting the free sterols/stanols of each sample by solid phase extraction; and detecting the level of the extracted free sterols/stanols in each sample by liquid chromatography tandem mass spectrometry.
|Ion guide and mass spectrometry device|
An electrode changeover switch which switches the connection state of electrodes is provided in the wiring path between eight electrodes through, arranged rotation-symmetrically about ion optical axis, and voltage generation switch which generates square wave high voltage ±v. When switch is switched as shown in the drawing, two circumferentially adjacent rod electrodes are connected to form one set, a square wave voltage of opposite phase is applied to circumferentially adjacent sets, and an effectively quadrupole electric field is formed.
|Methods and apparatus for obtaining enhanced mass spectrometric data|
A method comprising decomposing mass spectrometry data, especially of ion species that undergo multiple direction changes in a periodic manner, the data comprising signal and noise measured over time, into a sum of k harmonic component signals and a noise component, wherein the harmonic component signals and their number k are derived from the data and a determined quantity representative of the noise. The harmonic component signals and their number k may be determined iteratively on the basis of: using an initial value of k to calculate a minimised non-negative measure of difference r(k) between the measured and model data comprising data sets of k-harmonic component signals, and if r(k) does not lie within a noise range based on the quantity representative of the noise, changing the value of k and recalculating r(k) until r(k) lies within the noise range.
|Peak detection method for mass spectrometry and system therefor|
To enable more reliable detection of ion peaks from mass spectral data. Ion peaks are detected from mass spectrum by the following steps.
|Methods for inactiviation and/or extraction of a fungus test sample for characterization and/or identification using mass spectrometry|
The present invention is directed to a method for inactivation and/or extraction of fungus samples (e.g., mold or yeast samples), the method comprising the following sequential steps: (a) acquiring a test sample known to contain or that may contain fungus and suspending the test sample in a container containing water and/or suspension medium; (b) adding ethanol to the suspension; (c) centrifuging the container to pellet the fungus and removing and discarding the supernatant; (d) resuspending the fungus in formic acid; (e) adding acetonitrile to the sample; (f) centrifuging the sample; and (g) recovering the supernatant. In accordance with the present invention, the recovered supernatant can be subjected to mass spectrometry analysis for characterization and/or identification of the unknown fungus..
|Methods for inactiviation and extraction of acid-fast bacteria for characterization and/or identification using mass spectrometry|
The present invention is directed to a method for inactivation and/or extraction of acid-fast bacteria (e.g., mycobacteria or nocardia), the method comprising the following sequential steps: (a) acquiring a test sample known to contain or that may contain acid-fast bacteria and suspending the test sample in a container containing ethanol and beads; (b) bead beating and/or vortexing the container to break up clumps and/or disrupt acid-fast bacteria cells in the container; and (c) subsequently incubating the suspension for at least about 3 minutes at room temperature to inactivate any acid-fast bacteria contained in the test sample. In accordance with the present invention, the test sample can subsequently be pelleted by centrifugation, resuspended with formic acid, acetonitrile added, and subjected to mass spectrometry for characterization and/or identification of the acid-fast bacteria..
|Tandem time-of-flight mass spectrometer and method of mass spectrometry using the same|
A tandem time-of-flight mass spectrometer is offered which can perform ms/ms measurements efficiently without sample wastage by ingeniously combining flight time ranges required by precursor ions with measurement times actually taken to measure the precursor ions. The mass spectrometer has an array input means for causing the flight time ranges required by selected precursor ions and the actually taken measurement times in which the precursor ions are measured to be appropriately arrayed in a time-sequential manner such that the flight time ranges and measurement times do not overlap each other..
|Method and system for mass spectrometry|
A molecular weight is determined from an actually measured mass spectrum of a target substance, and a database search is performed to extract candidates of a chemical structural formula corresponding to the molecular weight (s2, s3). By using an algorithm for predicting a dissociation pattern, product ions to be produced by a dissociating operation are predicted for each candidate of the chemical structural formula (s4).
|System and methods for ionizing compounds using matrix-assistance for mass spectometry and ion mobility spectometry|
An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges.
|Analyzing target analytes in a sample using mass spectroscopy|
A method for determining an amount of an analyte in a sample by mass spectrometry can include the steps of (i) ionizing an analyte from the sample and a deuterated analog of the analyte, to produce an analyte ion and a deuterated analog ion, where the deuterated analog undergoes fragmentation and deuterium scattering during mass spectrometry; (ii) measuring an analyte ion signal and a deuterated analog ion signal by mass spectrometry, where the deuterated analog ion signal is measured using a mass transition resulting from fragmentation and deuterium scattering; and (iii) determining an amount of analyte in the sample using the analyte ion signal and the deuterated analog ion signal. Corresponding kits can include instructions for carrying out the method, together with a deuterated analog of the analyte selected to undergo fragmentation and deuterium scattering during mass spectrometry and exhibit a mass transition resulting from fragmentation and deuterium scattering..
|Bcl-2-like protein 11 srm/mrm assay|
Specific peptides, and derived ionization characteristics of those peptides, from the bcl-2-like protein 11 (bim) are provided that are particularly advantageous for quantifying the bim protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm). Such biological samples are chemically preserved and fixed where the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
|Tandem mass spectrometry using composite waveforms|
A tandem mass spectrometer system and method are described, where a composite voltage waveform is applied to so as to trap ion having selected m/z. The trapped ions may be subject to collision induced ionization dissociation (cid) by a selectable discrete frequency voltage waveform positioned so as to be in a notch in a broadband waveform.
|Mass spectrometry method, ion production device, and mass spectrometry system|
A mass spectrometry method of the present invention is such that a sample is heated to generate a gas and an ion that is produced from the gas is introduced into a mass spectrometer by using dart so that mass spectrometry is conducted.. .
|Data-processing system for chromatographic mass spectrometry|
Provided is a system for helping an operator determine the target ion, collision energy and other analysis conditions. A chromatogram selected by an operator is displayed in a chromatogram display area of an mrm measurement parameter determination window.
|Background subtraction-mediated data-dependent acquistion|
This application discloses a background subtraction-mediated data dependent acquisition method useful in mass spectrometry analysis. The method includes subtraction of background data from precursor ion spectra of a sample in real-time to obtain mass data of component(s) of interest and performs data-dependent acquisition on the component(s) of interest based on the resultant mass data from the background subtraction step.
|Method of detecting ethylated thymidine dna adducts|
A method of analyzing ethylated thymidine dna adducts is disclosed. The method comprises the steps of: providing leukocyte dna; adding at least one isotope-labeled internal standard and a plurality of enzymes to the leukocyte dna, and hydrolyzing the leukocyte dna into a plurality of nucleosides; using a solid-phase extraction column to extract the plurality of nucleosides; and using a stable isotope dilution nanoflow liquid chromatography-nanospray ionization tandem mass spectrometry to detect and quantify at least one ethylated thymidine dna adduct in the plurality of extracted nucleosides..
|Integrated electrospray ionization emitter and detection cell for parallel measurements by fluorescence and mass spectrometry|
An integrated mass spectrometer electrospray emitter and fluorescence detector allows improved volumetric measurements of separate components from a liquid chromatography column by improving correlation between the readings of these instruments and reducing dead volume and sample size requirements.. .
|Mass spectrometry apparatus|
There is provided a mass spectrometry apparatus comprising: an ion source arranged in a substantially horizontal orientation and from which a quantity of ions may be sourced, an ion filter device arranged for receiving a stream of ions for filtering thereof; and, an ion guide arranged so as to guide ions sourced from the ion source toward the ion filter device. The ion source and the ion filter device are arranged relative to one another so that the profile of the apparatus is reduced so as to minimise the effective footprint of the apparatus..
|Bio-chip for secondary ion mass spectroscopy and method of fabricating the same|
There are provided a bio-chip for secondary ion mass spectrometry and a method of fabricating the same, the bio-chip, which is a bio-chip for analyzing a biochemical material using the secondary ion mass spectrometry, including: a substrate; and core-shell particles positioned above substrate, wherein the core-shell particles each include a metal nanoparticle as a core and a metal shell surrounding the metal nanoparticle.. .
|Methods for detecting catecholamines by mass spectrometry|
Provided are methods for determining the amount of one or more of one or more of epinephrine (e), norepinephrine (ne), and dopamine (d) in a sample using mass spectrometry. The methods generally involve ionizing one or more of e, ne, and d in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of e, ne, and d in the sample.
|Method for triggering dependent spectra for data acquisition|
Methods and systems are provided for triggering an information dependent mass spectrometry scan in real time. A mass spectrometry scan of a separating sample mixture is performed by a mass spectrometer at each time interval of a time period.
|Data-processing system for chromatograph mass spectrometry|
In processing chromatographic data, collected by performing a measurement for each of the segments which respectively define time ranges, a system determines whether there is any boundary sandwiched between two temporally continuous segments whose measurement modes are the same and which has the same m/z value designated by an operator to be displayed. If such a boundary exists, the measurement mode common to the two neighboring segments across that boundary is identified, and the system determines whether the parameter values corresponding to that measurement mode are the same.
|Her3 protein srm/mrm assay|
The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the receptor tyrosine-protein kinase erbb-3, or her3, that are particularly advantageous for quantifying the her3 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
|System for determining drug resistance in microorganisms|
The present invention is based on the discovery that drug resistance in microorganisms can be rapidly and accurately determined using mass spectrometry. A mass spectrum of an intact microorganism or one or more isolated biomarkers from the microorganism grown in drug containing, isotopically-labeled media is compared with a mass spectrum of the intact microorganism or one or more isolated biomarkers from the microorganism grown in non-labeled media without the drug present.
|Mass spectrometry method, mass spectrometer, and mass spectrometry system|
A mass spectrometry method of the present invention is a method for conducting mass spectrometry in such a manner that an ion that is produced from a sample is introduced into a mass spectrometer by using dart or desi, wherein the mass spectrometer has an ion introduction part for introducing the ion thereinto and the ion introduction part is heated at a predetermined timing.. .
|Quantification of impurities for release testing of peptide products|
The present invention relates to a method for the quantitative determination of an impurity present in a peptide product, wherein the impurity cannot be separated from other impurities or the main product. The method particularly involves the use of high resolution mass spectrometry (ms) detection with or without high performance liquid chromatography (hplc).
|Process for analyzing gas emitted during drilling of a borehole|
A process analyses gases emitted during drilling of a borehole using oil based mud. The process comprises (a) using mass spectrometry, analysing the gas recovered during drilling through a hydrocarbon-poor zone at spaced apart locations to provide a mass spectrum for the gas emitted at each of the locations; (b) using mass spectrometry, analysing the gas recovered during drilling through a hydrocarbon-rich zone at one location to provide a mass spectrum for the gas emitted at the location; (c) using spectra from the measurements in (a) to extrapolate and predict a peak in a mass spectrum caused by compounds in the mud at a time when the drilling is proceeding through the hydrocarbon-rich zone; and (d) comparing the spectrum obtained in (b) with the predicted spectrum obtained in (c) to further predict at least one of the quantity and identity of the formation gases emitted from the hydrocarbon-rich zone..
|Combined spectroscopic method for rapid differentiation of biological samples|
A method for differentiating complex biological samples, each sample having one or more metabolite species. The method comprises producing a mass spectrum by subjecting the sample to a mass spectrometry analysis, the mass spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting the individual spectral peaks of the mass spectrum to a statistical pattern recognition analysis; identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the mass spectrum; and assigning the sample into a defined sample class..
|Synchronization of ion generation with cycling of a discontinuous atmospheric interface|
The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface..
|Method of mass spectrometry and a mass spectrometer|
The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas..
|Compounds, reactions, and screening methods|
The invention provides a method comprising identifying a successful metal-mediated conjugation reaction by analyzing a test mixture for the presence of a conjugation product. The invention provides a two-dimensional approach to reaction discovery in which many catalysts for many catalytic reactions can be tested simultaneously to provide an efficient discovery platform.
|Use of detector response curves to optimize settings for mass spectrometry|
Processes for identifying optimal mass spectrometer settings to produce the greatest confidence in sample constituent detection are provided. Data obtained on a mass spectrometer are analyzed by a quadratic variance function which accurately represents intensity variation as a variation of peak intensity.