|| List of recent Mass Spectrometry-related patents
|Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards|
A method for absolute protein or peptide quantitation by mass spectroscopy. A sample containing a protein or peptide of interest is prepared for mass spectroscopy analysis.
|Methods for identifying protein-protein interactions|
The invention generally relates to methods for identifying protein-protein interactions. In certain aspects, methods of the invention involve conducting a protein-fragment complementation assay on a sample to form a protein-protein complex between two proteins in the sample that only transiently interact under physiological conditions, separating the complexes from the sample, and analyzing a protein of the complex using a mass spectrometry technique..
|Imaging mass spectrometer and a method of mass spectrometry|
An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process.. .
|Methods for detecting lacosamide by mass spectrometry|
Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample..
|Methods for simultaneous quantification of thyroid hormones and metabolites thereof by mass spectrometry|
The invention provides methods for simultaneously detecting or simultaneously quantifying any combination of thyroxine (t4), triiodothyronine (t3), 3,3′-diiodo-l-thyronine (3,3′-t2), 3-iodothyronamine (t1am), and, optionally, reverse t3 (rt3) in a sample obtained from a human. The method involves a simple, sensitive, accurate, and specific isotope dilution tandem mass spectrometry method for the simultaneous quantification of any combination of t4, t3, 3,3′-t2, t1am, and, optionally, rt3 in a sample obtained from a human, e.g., in human plasma or serum samples.
|Fractional abundance estimation from electrospray ionization time-of-flight mass spectrum|
Methods and systems for detecting and quantifying signal peaks from esi-tof-ms data may include creating a signal model and a noise model for mass spectrometry (ms) data. The method may also include detecting a signal peak based, at least in part, on the signal model and the noise model for the ms data.
|Method for identifying microorganisms by mass spectrometry|
A method of identifying a microorganism by mass spectrometry, including acquiring at least one mass spectrum of said microorganism; for each acquired mass spectrum: detecting peaks of the spectrum in a predetermined mass range; generating a list of peaks identifying at most one peak in each interval of a predetermined subdivision of the range of mass-to-charge ratios, the width of the intervals of the subdivision logarithmically increasing along with the mass-to-charge ratio, and analyzing the list(s) of peaks obtained according to a knowledge base of previously-identified microorganisms and/or types of microorganisms.. .
|Hydrogel-mediated tissue analysis|
A method for analyzing the polypeptide content of animal tissue is described. The method includes the steps of (a) providing an animal tissue specimen; (b) depositing one or more portions of a hydrogel mixture including a protease on spatially discrete portions of the animal tissue specimen; (c) allowing sufficient time to pass for animal tissue under the hydrogel mixture to be form a digested mixture of animal tissue and hydrogel mixture; (d) removing the digested mixture from the animal tissue and extracting the polypeptides from the digested mixture to provide an extract; and (e) analyzing the polypeptide content of the extract by mass spectrometry..
|Method and system for analyzing protein or peptide|
A peptide is cleaved at various bonding sites into oligopeptides or similar fragments by digestion using proteinase k (s3). The obtained fragments are separated according to their kinds by reversed-phase chromatography and fractionated (s4), and each fragment is subjected to mass spectrometry to determine its mass (s6).
|Ion mobility spectrometry-mass spectrometry (ims-ms) with improved ion transmission and ims resolution|
An interface for an ion mobility spectrometry-mass spectrometry (ims-ms) system includes a first ion guide for receiving ions from an ims drift cell, and a second ion guide for receiving ions from the first ion guide, and positioned in a chamber separate from the first ion guide. Electrodes of the second ion guide subject the ions to an axial dc electric field while the second ion guide is held at a lower pressure than the first ion guide.
|Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid|
The invention relates to the detection of dha and epa. In a particular aspect, the invention relates to methods for detecting dha and epa by mass spectrometry and kits for carrying out such methods..
|Mass spectrometry systems and methods for improved multiple reaction monitoring|
The present teachings are directed to methods and apparatuses for mass spectrometry that include configuring mass spectrometry apparatus to perform a plurality of separate assays on ions fragmented from a given analyte, where each such analysis by the spectrometry apparatus is targeted at a different respective associated mass-to-charge ratio and provides a quantitative measure of the number of fragments thereof.. .
|Measurement plate for maldi mass spectrometry|
A measurement plate 10 for maldi mass spectrometry consists of a base plate 11 having an upper surface and a carbon sheet 12 laid on at least a portion of the upper surface. The carbon sheet 12 is a highly-oriented graphite sheet with the orientation direction being parallel to the upper surface.
|Strategic dynamic range control for time-of-flight mass spectrometry|
A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters.
|Enhancement of sensitivity and specificity of ketosteroids and keto or aldehyde containing analytes|
A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological matrices.
|Micro-sampling for aquatic chemical analysis|
The current invention describes in vivo and vitro (cultured) sampling technologies that allow direct temporal and spatial sampling from living ecosystems such as those associated with marine ecology. The optional use of parallel sampling methods, observatory design, provides for the ability to measure the response of individual organisms to a variety of both biotic and abiotic stresses.
|Circuit for generating a voltage waveform|
A circuit for generating a voltage waveform at an output node. The circuit includes a voltage rail connected to the output node via a voltage rail switch; an anchor node connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes two or more transistors connected in series; and a control unit configured to change the voltage at the output node by controlling the voltage rail switch and the bidirectional switch so that, if a load capacitance is connected to the output node, a resonant circuit is established between the inductor and the load capacitance.
|Ion detecting apparatus|
There is no small ion detecting apparatus that quickly and easily performs mass spectrometry under atmospheric pressure. Therefore, in order to solve the problem, an electrode arrangement and an electrode holding form for enabling water clusters in outside air to be detected with high sensitivity are provided.
|Method of tandem mass spectrometry|
A method of tandem mass spectrometry is disclosed. A quasi-continuous stream of ions from an ion source (20) and having a relatively broad range of mass to charge ratio ions is segmented temporally into a plurality of segments.
|Direct measurements of nanoparticles and virus by virus mass spectrometry|
Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages..
|Method for identifying microorganisms via mass spectrometry and score normalization|
Where: m is the distance calculated for the reference microorganism; n(m. .
|Aluminum-polymer resin composite and method for producing the same|
Disclosed is an aluminum-polymer resin composite. The composite includes i) aluminum and ii) a polymer resin bonded to the aluminum after modification of the aluminum surface with at least one surface modifier selected from the group consisting of sulfur-containing diazole derivatives, sulfur-containing diamine derivatives, sulfur-containing thiol derivatives, sulfur-containing pyrimidine derivatives, and sulfur-containing silane coupling agents.
|Multinotch isolation for ms3 mass analysis|
A mass spectrometry method for analyzing isobarically-labeled analyte compounds comprising (a) ionizing compounds including the isobarically-labeled analyte compounds to generate a plurality of precursor ion species comprising different respective m/z ratios, (b) isolating a precursor ion species, (c) fragmenting the precursor ion species to generate a plurality of first-generation fragment ion species comprising different respective m/z ratios, and (d) selecting and co-isolating two or more of the first-generation product-ion species, the method characterized by: (e) fragmenting all of the selected and isolated first-generation product ion species so as to generate a plurality of second-generation fragment ion species including released label ions; (f) generating a mass spectrum of the second-generation fragment ion species; and (g) generating quantitative information relating to at least one analyte compound based on peaks of the mass spectrum attributable to the released label ions.. .
|Systems, devices, and methods for sample analysis using mass spectrometry|
A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer.
|Identification of related peptides for mass spectrometry processing|
A method of identifying a related peak set from ms1 spectra data is provided. An intensity peak is selected from ms1 spectra data generated for a sample by a tandem mass spectrometer.
|Srm/mrm assay for the ephrin typa-a receptor 2 protein|
Specific peptides, and derived ionization characteristics of the peptides, from the ephrin type-a receptor 2 (epha2) protein are provided that are particularly advantageous for quantifying the epha2 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
|Single crystal cvd synthetic diamond material|
A single crystal cvd synthetic diamond material comprising: a total as-grown nitrogen concentration equal to or greater than 5 ppm, and a uniform distribution of defects, wherein said uniform distribution of defects is defined by one or more of the following characteristics: (i) the total nitrogen concentration, when mapped by secondary ion mass spectrometry (sims) over an area equal to or greater than 50×50 μm using an analysis area of 10 μm or less, possesses a point-to-point variation of less than 30% of an average total nitrogen concentration value, or when mapped by sims over an area equal to or greater than 200×200 μm using an analysis area of 60 μm or less, possesses a point-to-point variation of less than 30% of an average total nitrogen concentration value; (ii) an as-grown nitrogen-vacancy defect (nv) concentration equal to or greater than 50 ppb as measured using 77k uv-visible absorption measurements, wherein the nitrogen-vacancy defects are uniformly distributed through the synthetic single crystal cvd diamond material such that, when excited using a 514 nm laser excitation source of spot size equal to or less than 10 μm at room temperature using a 50 mw 46 continuous wave laser, and mapped over an area equal to or greater than 50×50 μm with a data interval less than 10 μm there is a low point-to-point variation wherein the intensity area ratio of nitrogen vacancy photoluminescence peaks between regions of high photoluminescent intensity and regions of low photolominescent intensity is <2× for either the 575 nm photoluminescent peak (nv0) or the 637 nm photoluminescent peak (nv); (iii) a variation in raman intensity such that, when excited using a 514 nm laser excitation source (resulting in a raman peak at 552.4 nm) of spot size equal to or less than 10 μm at room temperature using a 50 mw continuous wave laser, and mapped over an area equal to or greater than 50×50 μm with a data interval less than 10 μm, there is a low point-to-point variation wherein the ratio of raman peak areas between regions of low raman intensity and high raman intensity is <1.25×; (iv) an as-grown nitrogen-vacancy defect (nv) concentration equal to or greater than 50 ppb as measured using 77k uv-visible absorption measurements, wherein, when excited using a 514 nm excitation source of spot size equal to or less than 10 μm at 77k using a 50 mw continuous wave laser, gives an intensity at 575 nm corresponding to nv0 greater than 120 times a raman intensity at 552.4 nm, and/or an intensity at 637 nm corresponding to nv− greater than 200 times the raman intensity at 552.4 nm; (v) a single substitutional nitrogen defect (ns) concentration equal to or greater than 5 ppm, wherein the single substitutional nitrogen defects are uniformly distributed through the synthetic single crystal cvd diamond material such that by using a 1344 cm−1 infrared absorption feature and sampling an area greater than an area of 0.5 mm2, the variation is lower than 80%, as deduced by dividing the standard deviation by the mean value; (vi) a variation in red luminescence intensity, as defined by a standard deviation divided by a mean value, is less than 15%; (vii) a mean standard deviation in neutral single substitutional nitrogen concentration of less than 80%; and (viii) a colour intensity as measured using a histogram from a microscopy image with a mean gray value of greater than 50, wherein the colour intensity is uniform through the single crystal cvd synthetic diamond material such that the variation in gray colour, as characterised by the gray value standard deviation divided by the gray value mean, is less than 40%.. .
|Methods of detecting reverse triiodothyronine by mass spectrometry|
Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample..
|Use of windowed mass spectrometry data for retention time determination or confirmation|
A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans.
|Techniques for quantification of samples|
Techniques are described for quantification of molecules in a sample. Mass spectrometry is performed to obtain ionization intensities for precursor and product ions originating from a particular molecule.
|Atmospheric pressure ion source for mass spectrometry|
A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as atmospheric pressure chemical ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions.
|Nanomanipulation coupled nanospray mass spectrometry (nms)|
A coupled nanomanipulation and nanospray mass spectrometry (nms) system for single cell, single organelle, and ultra-trace molecular analysis is disclosed herein. The system primarily comprises a bio-workstation coupled to a nms.
|Methods, apparatus, and system for mass spectrometry|
A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments.
|Diathermy knife ionisation source|
A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife.
|Determining the geographic origin of metals|
A method of determining the geographic origin of a metal can comprise measuring a first isotope and a second isotope of the metal by high-resolution mass spectrometry; calculating a ratio of the first isotope and the second isotope; comparing the ratio to native ratios of isotopes of the metal of native samples from a plurality of geographic locations using a database; and matching the ratio to a geographic location.. .
|Srm/mrm assay for the insulin receptor protein|
Specific peptides, and derived ionization characteristics of the peptides, from the insulin receptor protein (ir), and its isoforms ir-a and ir-b, that are particularly advantageous for quantifying the ir protein, ir-a isoform and/or ir-b isoform, directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
There is provided an ion reflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The reflector includes an electric field capable of causing a flow of ions focused through a first spatial region to be focused toward a second spatial region, whereby the first and second spatial regions are aligned with respective axes of travel..
|System and method for applying curtain gas flow in a mass spectrometer|
A system of mass spectrometry is disclosed having an ion source for generating ions at substantially atmospheric pressure. The system has a sampling member with an orifice disposed therein.
|Intelligent background data acquisition and subtraction|
A scan of a separating sample mixture is received from a mass spectrometer at each interval of a plurality of intervals. It is determined at a first interval that a received mass spectrometry scan at the first interval and one or more preceding received mass spectrometry scans include a varying ion signal that represents an ion of a known compound and has an intensity above a threshold level.
|New use for a compound as a matrix in the specific detection, identification and/or quantification of alkaloids by maldi-tof mass spectrometry|
There is provided (i) a method of analysing small molecules that may have a mass of <800 da, in particular alkaloids, said method being generally referred to as maldi-tof-ms (or maldi time-of-flight mass spectrometry), which is an acronym for a method of analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Also provided is (ii) a molecule according to formula (i) and the use of the molecule as a matrix in the analysis method..
|Method for measuring acetic acid concentration in blood plasma|
The present invention relates to providing a simple and highly reproducible method for measuring the concentration of acetic acid in blood plasma by using a gas chromatography/mass spectrometry (gc/ms), and more specifically relates to a method for measuring the concentration of acetic acid in blood plasma by using a gas chromatography/mass spectrometry (gc/ms), which comprises extracting acetic acid in blood plasma with methyl-tert-butyl ether (mtbe).. .
|Capturing of cell fluid and analysis of its components under observation of cells and instruments for the cell fluid capturing and the analysis|
A method captures cellular components from a single cell and performs mass spectrometry on the components. The method includes inserting a nanospray ionization capillary tip into a specific region of the cell under observation with a microscope.
|Quantification of transthyretin and its isoforms|
The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry.
|Improvements in or relating to mass spectrometry|
There is provided an ion guide arrangement comprising a guide assembly comprising a plurality of elongate members arranged so as to be spaced about a common axis. The elongate members are capable of being in electrical association with one another so as to guide a stream of ions along an intended pathway substantially aligned with the axis.
|Simultaneous inorganic mass spectrometer and method of inorganic mass spectrometry|
An inorganic mass spectrometer capable of measuring a relevant and large or the full mass spectral range simultaneously may include a suitable ion source (e.g., an icp mass spectrometer with an icp ion source), an ion transfer region, ion optics to separate ions out of a plasma beam, a mattauch-herzog type mass spectrometer with a set of charged particle beam optics to condition the ion beam before an entrance slit, and a solid state multi-channel detector substantially separated from ground potential and separated from the potential of the magnet.. .
|Covalently functionalized nanodiamond-based maldi matrices and methods of use thereof|
The present disclosure relates to functionalized nanodiamonds comprising at least one maldi matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure also relates to methods of performing matrix-assisted laser desorption/ionization-mass spectrometry (maldi-ms), for example on small molecules, using matrices comprising at least one maldi matrix covalently bonded to a nanodiamond..
|Method and apparatus for leak testing containers|
Close containers which are filled with a consumer product are tested on leakiness by means of mass spectrometry (10) in that an impact (an(p)) by the consumer product (p) upon the surrounding atmosphere (a(p)) of the container to be leak tested is monitored by the mass spectrometry (10).. .
|Categorisation of biological deposits using matrix assisted laser desorption ionisation mass spectrometry|
A method of categorising a human according to pre-determined categories using matrix assisted laser desorption ionisation mass spectrometry (maldi-ms) is disclosed. A method is provided to discriminate humans based on gender, for example, by comparing maldi-ms sample spectral data in the m/z range 2,000 to 30,000 and comparing these sample spectral data with reference spectral data obtained from pre-categorised humans..
|Improved capillary electrophoresis-electrospray ionization-mass spectrometry system|
Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (ce) and ce in conjunction with electrospray ionization (esi) as an input to a mass spectrometry system (ms). Some embodiments use a high voltage isolated ce power supply that is configured to float on the high voltage output of an esi-ms power supply, with a protective resistance in the esi-ms path, as well as dc/dc converter isolation and communication system isolation for the isolated ce power supply.
|Chromatograph mass spectrometry data processing apparatus|
Even when only mass spectra wherein the reproducibility of peak intensities is low are obtained in a mass spectrometry apparatus using, for example, a maldi ion source, the correction of shifts in retention time using tics for a plurality of specimens is performed with good precision. For each mass spectrum, variable scaling is executed which combines such first scaling as to equalize the extent of variations in signal intensity values in one mass spectrum, among different mass spectra, and second scaling for performing weighting according to relative variations in signal intensity values for each mass spectrum (s3).
|Multiplexed detection with isotope-coded reporters|
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (lc ms/ms). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag.
|Apparatus for improved immunosuppressant drug monitoring|
A liquid chromatography/mass spectrometry system includes: a source of a first mobile phase solvent consisting essentially of water plus 10 mm ammonium formate plus 0.05% formic acid; a source of a second mobile phase solvent consisting essentially of methanol plus 10 mm ammonium formate plus 0.05% formic acid; a chromatography column comprising a length of 30 mm or less of a stationary phase comprising an 8-carbon alkyl chain material bonded to 2.6 μm diameter particles having solid silica cores surrounded by porous silica outer layers; an electrospray ion source of a mass spectrometer fluidically coupled to the chromatography column so as to generate ions therefrom; a mass analyzer of the mass spectrometer operable to quantitatively detect the ions; and a programmable processor electronically coupled to the mass analyzer and comprising instructions operable to determine, based on the ion detection, a concentration of everolimus, sirolimus, tacrolimus, or cyclosporin a.. .
|Apparatus for elemental analysis of particles by mass spectrometry|
A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
|Computer-assisted structure identification|
The invention relates to a method for analysing mass spectral data obtained from a sample in gc×gc (2-dimensional) mass spectrometry, comprising: (a) comparing mass spectral data of an analyte with mass spectral data of candidate compounds of known structure in a data library; (b) identifying a plurality of candidate compounds from the library based on similarities of mass spectral data; (c) predicting, for each candidate compound, a value of at least one analytical property using a quantitative model based on a plurality of molecular descriptors; and (d) calculating a match score for each candidate compound based on the value predicted in step (c) and a measured value of the analytical property for the analyte.. .
|Nonaqueous electrolyte air battery|
A nonaqueous electrolyte air battery has a positive electrode comprises at least a catalyst which activates oxygen, a conductive material and a binder, when a thermal decomposition starting temperature of the binder is t1° c. And a thermal decomposition ending temperature of the binder is t2° c.
|Nonaqueous electrolyte air battery|
A nonaqueous electrolyte air battery has s positive electrode comprises at least a catalyst which activates oxygen, a conductive material and a binder, when a thermal decomposition starting temperature of the binder is t1° c. And a thermal decomposition ending temperature of the binder is t2° c.
|Adaptive and targeted control of ion populations to improve the effective dynamic range of mass analyser|
A method of mass spectrometry is disclosed wherein one or more relatively abundant or intense species of ions in a first population of ions are selectively attenuated so as to form a second population of ions. The total ion current of the second population of ions is then adjusted so that the ion current corresponding to ions which are onwardly transmitted to a mass analyser comprising an ion detector is within the dynamic range of the ion detector..
|Methods for detecting vitamin c by mass spectrometry|
Provided are methods for determining the amount of vitamin c in a sample using mass spectrometry. The methods generally involve ionizing vitamin c in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin c in the sample..
|Photo-dissociation of proteins and peptides in a mass spectrometer|
A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2d or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected.
|Cell identification device and program|
An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined.
|Isotopic labeling for the measurement of global protein levels and turnover in vivo|
An entire complement or plurality of isotopically labeled amino acids are introduced into the diet of a test subject. Sufficient amounts of the isotopically labeled amino acids are provided to the subject in order to ensure that the subject incorporates a large percentage of isotopically labeled amino acids into newly synthesized proteins.
|Laser ablation cell|
A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel.
|Mass spectrometers comprising accelerator devices|
A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
|Biomarker for ovarian cancer ctap3-related proteins|
The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer.
|Methods for making microarrays and their uses|
The present invention provides microarrays that can be analysed by more than one technique using a non-covalent ligand attachment strategy to solid supports such as indium tin oxide (ito) covered transparent glass slides. This provides, inter alia, glycan arrays on a micrometer scale which allow multimodal readout by maldi-tof-ms, fluorescence and optical microscopy.
|Chemical identification using a chromatography retention index|
Provided herein is technology relating to identifying unknown compounds and particularly, but not exclusively, to methods and systems for identifying unknown compounds by gas chromatography-mass spectrometry by use of retention index as a second dimension for identification.. .