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Mass Spectrometry patents



      

This page is updated frequently with new Mass Spectrometry-related patent applications.




Date/App# patent app List of recent Mass Spectrometry-related patents
04/07/16
20160099139 
 Mass microscope apparatus patent thumbnailMass microscope apparatus
A mass microscope apparatus includes: a measuring unit including an ionization unit configured to ionize a sample present in an observation region, and a mass spectrometry unit configured to perform mass spectrometry of ions generated by the ionization unit; an object moving device configured to relatively move the observation region as to the sample; and a switching unit configured to switch measurement conditions of the measuring unit depending on whether the mass microscope apparatus is operating in a moving measurement mode where the observation region is moved by the object moving device to sequentially perform measurement by the measuring unit, and a stationary measurement mode where the observation region is stationary and measurement is performed by the measuring unit.. .
Canon Kabushiki Kaisha


04/07/16
20160099137 
 Mass spectrometry by detecting positively and negatively charged particles patent thumbnailMass spectrometry by detecting positively and negatively charged particles
The disclosure features mass spectrometry systems and methods that include an ion source, an ion trap, a detector subsystem featuring first and second detector elements, and a controller electrically connected to the ion source, the ion trap, and the detector subsystem and configured so that during operation of the system, the controller: applies an electrical signal to the ion source to generate positively and negatively charged particles from sample particles in the system; applies an electrical signal to the ion trap to eject a plurality of particles from the ion trap through a common aperture of the ion trap, and determines information about the sample particles based on first and second electrical signals generated by the ejected particles.. .
908 Devices Inc.


04/07/16
20160099136 
 Systems and methods for acquiring data for mass spectrometry images patent thumbnailSystems and methods for acquiring data for mass spectrometry images
Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.


04/07/16
20160098514 
 Predictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample patent thumbnailPredictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample
A programmed computer functioning as a classifier operates on mass spectral data obtained from a blood-based patient sample to predict indolence or aggressiveness of prostate cancer. Methods of generating the classifier and conducting a test on a blood-based sample from a prostate cancer patient using the classifier are described..
Biodesix, Inc.


04/07/16
20160097749 
 Analyte mass spectrometry quantitation using a universal reporter patent thumbnailAnalyte mass spectrometry quantitation using a universal reporter
Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.. .

03/31/16
20160092151 
 Mass spectrometry data processing apparatus patent thumbnailMass spectrometry data processing apparatus
A mass spectrometry data processing apparatus having a function of displaying a plurality of msn spectra in an arranged manner is allowed to display these msn spectra in a state where a user can easily grasp presence or absence of a common neutral loss. A mass spectrometry data processing apparatus 20 that displays, on a display screen, an msn spectrum resulting from mass spectrometric analysis of n−1 stage dissociation, where n is integer of two or more, of an ion, includes: a precursor ion identifying section 32 configured to identify, for each of a plurality of msn spectra, a mass-to-charge ratios m/z of a precursor ion from which the msn spectra are obtained; and a spectrum aligning section 33 configure to display the msn spectra on the display screen in a vertically arranged manner such that positions of the mass-to-charge ratios m/z of the respective precursor ions are located at a same horizontal position of the display screen..
Shimadzu Corporation


03/31/16
20160091467 
 Prediction of fuel properties patent thumbnailPrediction of fuel properties
A system is described that includes a known fuels database of data from gas chromatography-mass spectrometry analyses of a library of fuels with known fuel properties for a multiple known fuel samples. Gas chromatography-mass spectrometry equipment can acquire gas chromatography-mass spectrometry data for an unknown fuel sample.
The Government Of The United States Of America, As Represented By The Secretary Of The Navy


03/24/16
20160087049 
 Epitaxial silicon wafer patent thumbnailEpitaxial silicon wafer
An epitaxial silicon wafer includes: a silicon wafer; and a silicon epitaxial layer formed on the silicon wafer, in which a w concentration obtained by a metal analysis of a surface of the silicon epitaxial layer using an inductively coupled plasma mass spectrometry is 1×106 atoms/cm2 or less. Further, the w concentration obtained by the metal analysis of the surface of the silicon epitaxial layer using the inductively coupled plasma mass spectrometry is preferably 1×107 atoms/cm2 or less..
Sumco Corporation


03/24/16
20160086786 
 Isolation of charged particle optics from vacuum chamber deformations patent thumbnailIsolation of charged particle optics from vacuum chamber deformations
A charged particle processing apparatus includes a vacuum chamber, an optics plate, charged particle optics mounted to the optics plate, and mounting members coupled between the optics plate and a chamber wall. The mounting members are configured for isolating the optics plate from deformation of the chamber wall, as may occur due to a pressure differential between the chamber interior and the environment outside the chamber.
Agilent Technologies, Inc.


03/24/16
20160086785 
 Methods and devices for generating double emulsions patent thumbnailMethods and devices for generating double emulsions
The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer.
University Of Washington Through Its Center For Commercialization


03/24/16
20160086783 

Improved data quality after demultiplexing of overlapped acquisition windows


Systems and methods are provided for identifying missing product ions after demultiplexing product ion spectra produced by overlapping precursor ion transmission windows in sequential windowed acquisition tandem mass spectrometry. Overlapping sequential windowed acquisition is performed on a sample.
Dh Technologies Development Pte. Ltd.


03/24/16
20160086782 

Species detection using mass spectrometry


Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (mrm) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer.
Dh Technologies Development Pte. Ltd.


03/24/16
20160086780 

Multi-segment injection-capillary electrophoresis-mass spectrometry (msi-ce-ms): a multiplexed screening platform and data workflow for chemical analysis


Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (ce-ms) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (ce) run.
Mcmaster University


03/17/16
20160079052 

Method and mass spectrometry


A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (mr tof) mass spectrometry..
Thermo Fisher Scientific (bremen) Gmbh


03/17/16
20160079050 

Mass spectrometry method, ion generator and mass spectrometry system


A mass spectrometry method includes a step of atomizing liquid including a sample using an ultrasonic transducer; a step of transferring the atomized liquid; a step of generating ions from the transferred liquid using a dart ion source; and a step of analyzing a mass spectrometry by introducing the generated ions into a mass spectrometer.. .
Bio Chromato, Inc.


03/17/16
20160079049 

Methods for detecting reverse triiodothyronine by mass spectrometry


Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample..
Quest Diagnostics Investments Incorporated


03/17/16
20160079048 

Systems and methods for rapidly screening samples by mass spectrometry


Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079047 

Systems and methods for using variable mass selection window widths in tandem mass spectrometry


Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079046 

Multiple frequency rf amplifier, mass spectrometer including the same, and mass spectrometry mass spectrometer


Provided is a multiple frequency radio frequency (rf) amplifier. The multiple frequency rf amplifier includes a waveform generation circuit configured to generate an rf signal by amplitude and frequency-modulating a reference waveform signal, a drive amplifier circuit configured to drive-amplify the rf signal, and a power amplifier circuit configured to generate a multiple frequency rf voltage signal through a power amplification of the drive-amplified rf signal and output the multiple frequency rf voltage signal to an ion trap for a mass spectrometry..
Korea Basic Science Institute


03/10/16
20160071710 

Mass spectrometry with selective ion filtration by digital thresholding


The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process..
Ibis Biosciences, Inc.


03/10/16
20160069848 

Liquid chromatograph mass spectrometer


In a liquid chromatograph mass spectrometer (lc/ms) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional lc or similar lc with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the lc depending on the kind of column or other factors or the degree of ease of ionization in the ms. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information.
Shimadzu Corporation


03/03/16
20160061848 

Mass spectrometry of steroidal compounds in multiplexed patient samples


The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry..
Quest Diagnostics Investments Incorporated


03/03/16
20160061790 

Quantification of asphaltene inhibitors in crude oil using thermal analysis coupled with mass spectrometry


The present invention generally relates to a novel method for the characterization and quantification of involatile macromolecules in hydrocarbon samples of crude oil. More particularly, the method utilizes pyrolysis/gas chromatography/mass spectrometry (py/gc/ms, py/gc/ms/ms or py/gc/triple quad ms) to detect and quantify polymeric asphaltene inhibitors in crude oil..
Ecolab Usa Inc.


03/03/16
20160060688 

Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest


This invention pertains to identifying one or more hybridization probes sequestered within (or optionally released from the intact) cells or microorganisms by mass spectrometry to thereby determine a trait of the cells or microorganisms and/or to identify the cells or microorganisms themselves. The cells or microorganisms can come from a subject and the information obtained from the mass spectrometry analysis may, if clinically relevant, optionally be used to diagnose and/or treat the subject..
Advandx, Inc.


02/25/16
20160056031 

Sample analysis for mass cytometry


The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (la-icp-ms). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the icp, followed by analysis by mass cytometry..
Fluidigm Canada Inc.


02/25/16
20160056030 

System and delicate membrane condensed phase membrane introduction mass spectrometry (cp-mims)


Systems and methods for analyzing a sample comprising an analyte selected from a volatile organic compound, a semi-volatile organic compound, a non-volatile organic compound, a polar organic compound and a halogenated non-volatile organic compound are provided. The systems comprises an ionization source, a flow cell or an immersion probe with a delicate membrane, the flow cell or immersion probe for accepting the sample, and the delicate membrane interface in fluid communication with the ionization source and a mass spectrometer.

02/25/16
20160056028 

Ultraclean autosampler with syringe delivery for mass spectrometry


A system can include a valve assembly including a first valve and a second valve in fluid communication with the first valve. The valve assembly can be configured to deliver one or more of a sample, a chemical (e.g., an acid, a base, an organic chemical, etc.), and a standard via flow of a working fluid facilitated by one or more syringe pumps.
Elemental Scientific, Inc.


02/25/16
20160056027 

Quantitative analysis method using mass spectrometry wherein laser pulse energy is adjusted


A quantitative analysis method using maldi mass spectrometry wherein laser pulse energy is adjusted is disclosed. More particularly, a method for measuring the equilibrium constant of a proton exchange reaction between a matrix and a sample at a constant temperature, by dividing an ion signal ratio by a value (concentration ratio) obtained by dividing the concentration of the sample by the concentration of the matrix, may include (i) obtaining maldi mass spectra having constant tics by adjusting the intensity of energy applied to a specimen having a predetermined amount of a matrix and a predetermined amount of a sample mixed therein and (ii) measuring the maldi mass spectra obtained in step (i) for a value (ion signal ratio) obtained by dividing sample ion signal strength by matrix ion signal strength..
Snu R &db Foundation


02/25/16
20160054332 

Mass spectrometric determination of drug resistance


The invention relates to a method to determine drug resistance in microbes. The method relates to measuring the drug resistance conferring protein by mass spectrometry.
Erasmus University Medical Center Rotterdam


02/25/16
20160054323 

Srm/mrm assay for subtyping lung histology


The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins that are particularly advantageous for quantifying the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


02/25/16
20160053297 

Thyroglobulin quantitation by mass spectroscopy


Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample..
Quest Diagnostics Investments Incorporated


02/18/16
20160049287 

Ion trap array


The invention “ion trap array (ita)” pertains generally to the field of ion storage and analysis technologies, and particularly to the ion storing apparatus and mass spectrometry instruments which separate ions by its character such as mass-to-charge ratio. The aim of this invention is providing an apparatus for ion storage and analysis comprising at least two or more rows of parallel placed electrode array wherein each electrode array includes at least two or more parallel bar-shaped electrodes, by applying different phase of alternating current voltages on different bar electrodes to create alternating electric fields inside the space between two parallel electrodes of different rows of electrode arrays, multiple linear ion trapping fields paralleled constructed in the space between the different rows of electrode arrays which are open to adjacent each other without a real barrier.
Fudan University


02/18/16
20160049283 

Laser ablation cell


A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel.
Paul Scherrer Institut


02/18/16
20160047831 

Mass spectral analysis


The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis..
Purdue Research Foundation


02/18/16
20160047782 

Mass spectrometry (ms) identification algorithm


A system includes a gas chromatograph configured to determine experimental chromatographic data including retention times associated with samples. The system also includes a mass spectrometer configured to determine experimental mass spectral data associated with samples.
Smiths Detection Inc.


02/11/16
20160042936 

Compact mass spectrometer


Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.


02/11/16
20160042930 

Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


02/11/16
20160041183 

Thyroglobulin quantitation by mass spectrometry


Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample..
Quest Diagnostics Investments Incorporated


02/04/16
20160035552 

Method and system for tandem mass spectrometry


A method of data independent ms-ms analysis is disclosed. The method comprises ramping or stepping in small steps of a wide (at least 10 amu) parent mass window in a first parent selecting mass spectrometer (ms1), arranging rapid ion transfer through a collisional cell, either by axial gas flow or by an axial dc field or by a travelling rf wave, frequently pulsing an orthogonal accelerator with a string of time-encoded pulses, analyzing fragment ions in a multi-reflecting time-flight mass spectrometer, acquiring data in a data logging format, and decoding signal strings corresponding to the entire scan of parent masses, such that fragment spectra are formed based on time correlation between fragment and parent masses.
Leco Corporation


02/04/16
20160035551 

Data dependent control of the intensity of ions separated in multiple dimensions


A method of mass spectrometry is disclosed comprising setting an attenuation factor of an attenuation device to a first value and then separating or filtering ions according to a first physico-chemical property and separating or filtering ions according to a second physico-chemical property and obtaining a multi-dimensional array of data. The most intense ion peak within one or more subsets of the multi-dimensional array of data is determined.
Micromass Uk Limited


02/04/16
20160035550 

Plasma cleaning for mass spectrometers


A mass spectrometry (ms) system may be cleaned by generating plasma and contacting an internal surface of the system to be cleaned with the plasma. The system may be switched between operating in an analytical mode and in a cleaning mode.
Agilent Technologies, Inc.


02/04/16
20160033527 

System and determining amino acid sequence of polypeptide


This invention discloses systems and methods for determining the sequence of amino acids in a short peptide chain that constructs a protein. The protein is firstly hydrolyzed to various short peptides and amino acid enantiomers.
Chung Yuan Christian University


02/04/16
20160033522 

Methylcitrate analysis in dried blood spots


There is provided a method of measuring methylcitrate (mca) in a sample by derivatizing the mca, for example with 4-[2-(n,n-dimethylamino)ethylaminosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole (daabd-ae); measuring a level of the derivatized mca; and determining the level of mca from the measured level. The sample may be a dried blood spot (dbs), and the extraction and derivatization may be carried out simultaneously.
Children's Hospital Of Eastern Ontario


02/04/16
20160032273 

Characterization of mrna molecules


The present invention describes methods for the characterization of mrna molecules during mrna production. Characterizing mrna includes processes such as oligonucleotide mapping, reverse transcriptase sequencing, charge distribution analysis, and detection of rna impurities.
Moderna Therapeutics, Inc.


02/04/16
20160031047 

Method and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system


A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (cg-ms) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the gc-ms system, at a location between a high vacuum end of a transfer line and a mass analyzer of the gc-ms system.
Thermo Finnigan Llc


02/04/16
20160030369 

Fkbp52 targeting agent pharmaceutical compositions


Liposomes comprising an fkbp52 targeting agent (fta) are disclosed. Pharmaceutical compositions comprising an fta, a solvent, and a surfactant are disclosed.
The Board Of Regents Of The University Of Texas System


01/28/16
20160027631 

Measurement device, measurement apparatus, and method


A metal film of a measurement device including a transparent dielectric substrate is irradiated with first light from a transparent dielectric substrate side, an optical electric field enhanced by an optical electric field enhancing effect of a localized plasmon induced to a surface of the metal film by the irradiation is generated, light emitted from the transparent dielectric substrate side is detected, a specimen installed on a surface of a metal fine concavo-convex structure layer and a matrix agent are irradiated with second light from a side opposite to the side of the irradiation with the first light in a state where a voltage is applied to the metal fine concavo-convex structure layer through a voltage application electrode, an analysis target substance for mass spectrometry in the specimen is desorbed from the surface by the irradiation, and the desorbed analysis target substance is detected.. .
Fujifilm Corporation


01/28/16
20160027629 

Apparatus for elemental analysis of particles by mass spectrometry


A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
Fluidigm Canada Inc.


01/28/16
20160027628 

Improved data dependent control


A method of mass spectrometry is disclosed comprising obtaining first data at a first time and/or location and second data at a second subsequent time and/or location. A future trend or rate of change in the data is predicted from the first and second data.
Micromass Uk Limited


01/28/16
20160025742 

Synthesis and use of isotopically-labelled glycans


Isotopically-labelled glycans and their synthesis and use as internal standards in the analysis by mass spectrometry of glycan mixtures is described. The methods of synthesis described herein may be used conveniently to prepare libraries of heavy glycans for use in the qualitative and quantitative identification of glycans in natural samples..
AsociaciÓn Centro De InvestigaciÓ Cooperativa En Biomateriales


01/28/16
20160025741 

System and the detection of allergens


Methods and systems for detecting allergens using mass spectrometry are provided herein. In some aspects, a sample can be screened for the presence or quantity of ovalbumin, lysozyme, casein (isoform s1 and s2), lactoglobulin, high and low glutens, wheat, rye, oats, barley, mustard, sesame, and various types of nuts including macadamia, pistachio, brazil, walnuts, peanuts and hazelnuts by detecting one or more peptides specific to the allergen of interest using selected mrm transitions..
Dh Technologies Development Pte. Ltd.


01/28/16
20160025692 

Analysis system


An analysis system is provided with: a storage unit that stores first information associating mass spectrometry result information with an analysis condition concerning ion mobility separation; and a control unit that determines, as a first analysis condition for an ion to be measured, the analysis condition associated with the mass spectrometry result information of the first information corresponding to the mass spectrometry result information of the ion to be measured.. .
Hitachi High- Technologies Corporation


01/28/16
20160025691 

Chromatography/mass spectrometry data processing device


Using the intensity ratio of peaks on a standard mass spectrum of the target compound and peaks with the same m/z on the measured mass spectrum near the retention time of said compound, a scale factor waveform close to the chromatogram shape based on the target compound alone is computed, and m/z candidates for quantitation are extracted based on the correlation between the measured mass chromatogram of the target compound and the scale factor waveform. Furthermore, an intensity ratio is determined with reference to the m/z peaks showing the greatest scale factor on the measured mass spectrum at the measurement time point showing the greatest scale factor in the scale factor waveform, and m/z candidates for quantitation/confirmation are narrowed down based on whether they fall within an allowable range based on peak intensity ratio on the standard mass spectrum..
Shimadzu Corporation


01/28/16
20160025603 

Airborne agent collectors, methods, systems and devices for monitoring airborne agents


Air flow systems, devices and methods for monitoring airborne agents include airborne agent collectors. Airborne agent collectors for collecting and detecting the presence and/or identification of an airborne agent(s) include a soluble and hydrophilic polycaprolactone (pcl) that has been treated with a base (e.g., a base having a ph greater than 8 (e.g., naoh, nahco3, koh, na2co3, and ca(oh)2) and in some embodiments, also treated with a neutralizing agent for increasing hydrophilicity.
Diomics Corporation


01/28/16
20160024492 

Removal of dna fragments in mrna production process


The present invention describes methods of removing dna from an rna transcript during the mrna production process. The method embodies procedures for obtaining an in vitro transcription product, and removing any dna from the product.
Moderna Therapeutics, Inc.


01/21/16
20160020083 

Adjusting precursor ion populations in mass spectrometry using dynamic isolation waveforms


A mass spectrometry technique for isolating a plurality of isolated ions from a plurality of injected ions using a dynamic isolation waveform to create at least one isolation notch. Isolating the plurality of isolated ions may include collecting at least a first target ion, but not a second target ion, using the at least one isolation notch for a first period of time; changing at least one property of the at least one isolation notch; and collecting at least the first target ion and the second target ion using the at least one isolation notch for a second period of time..
President And Fellows Of Harvard College


01/21/16
20160020082 

Mass spectrometer system and method


An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage u, an amplitude v of a radio-frequency voltage, and a frequency f of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger.
Hitachi High-technologies Corporation


01/21/16
20160020080 

Sample plate for maldi-tof mass spectrometer and manufacturing the sample plate and mass spectrometry method using the sample plate


The present invention relates to a sample plate to be used for a maldi-tof (matrix assisted laser desorption ionization time of flight) mass spectrometer, and more particularly, to a sample plate for a maldi-tof mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a maldi-tof mass spectrometer so as to overcome the limits of the gas chromatography method of the related art.
Industry-academic Cooperation Foundation, Yonsei University


01/21/16
20160020076 

Collision cell for tandem mass spectrometry


A method and apparatus for tandem mass spectrometry is disclosed. Precursor ions are fragmented and the fragments are accumulated in parallel, by converting an incoming stream of ions from an ion source (10) into a time separated sequence of multiple precursor ions which are then assigned to their own particular channel of a multi compartment collision cell (40).
Thermo Fisher Scientific (bremen) Gmbh


01/21/16
20160018410 

Deep maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof


A method of analyzing a biological sample, for example serum or other blood-based samples, using a maldi-tof mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a maldi-tof sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument.
Biodesix, Inc.


01/21/16
20160018368 

Mass spectrometry s


Proposed schematic ion optical diagrams allow to developing different ms types.. .

01/21/16
20160018361 

System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry


An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges.

01/21/16
20160017397 

Monitoring a dynamic system by liquid chromatography-mass spectrometry


The present invention provides a method for monitoring of profile changes of components in a dynamic system such as a cell-free in vitro protein synthesis system by using liquid chromatography (lc) combined with mass spectrometry (ms). In an additional aspect, this invention provides a method for enhancing the yield and/or reproducibility in a cell-free protein synthesis system by modulating the level and/or activity of a protein component that has regulatory effects on the system..
Sutro Biopharma, Inc.


01/14/16
20160013040 

Ion trap mass spectrometer


An ion trap mass spectrometer including an ion trap analyzer, an ion packet injector, and an ion detector is disclosed, along with a method of mass spectrometry. The ion packet injector injects packets of ions into a field of the ion trap analyzer.
Leco Corporation


01/14/16
20160013037 

Apparatus and methods for plasma-assisted reaction chemical ionization (parci) mass spectrometry


Plasma-assisted reaction chemical ionization (parci) provides highly sensitive elemental analysis by producing positively and negatively charged ions. The parci apparatuses, kits, and methods described in this application relate to systems that comprise a chemical reaction interface (cri) containing reactant gas plasma and an ionization chamber that is downstream from the cri.
Georgetown University


01/14/16
20160013036 

Improved lock component corrections


A method of mass spectrometry is disclosed comprising initially calibrating or recalibrating a mass spectrometer at a time t0 and at the same time measuring a time of flight or mass to charge ratio m0 of one or more lockmass ions. The mass spectrometer is then operated at a subsequent time t1 and the time of flight or mass to charge ratio m1 of the one or more lockmass ions is measured at subsequent time t1.
Micromass Uk Limited


01/14/16
20160011205 

Mass spectrometry method using matrix


Where r is an alkyl group having 4 to 12 carbon atoms. The mass spectrometry method as described above, wherein an analysis object is a hydrophobic compound, particularly, a hydrophobic peptide..

01/14/16
20160007625 

Coffee drink


Provided is a coffee beverage, including the following components (a), (b), and (c): (a) at least one selected from the group consisting of catechol and pyrogallol; (b) 3,4-dicaffeoyl-1,5-quinolactone; and (c) chlorogenic acids, in which a ratio of a total peak area of the component (a) to a peak area of the component (b), ((a)/(b)), as determined by liquid chromatography-time of flight mass spectrometry (lc-tof/ms) of the coffee beverage, is from 0 to 2.0, and in which a content of the component (c) in the coffee beverage is from 0.05 to 2% by mass.. .
Kao Corporation


01/07/16
20160005582 

Ion trap mass spectrometer


A mass spectrometer including an ion source, an ion guide, a pulsed converter, and an electrostatic analyzer is disclosed, along with a method of mass spectrometry and an ion injector. The ion source generates ions, such as ions within a continuous or a quasi-continuous ion beam.
Leco Corporation


01/07/16
20160005579 

Multi-pole ion trap for mass spectrometry


An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface.
The Rockefeller University


01/07/16
20160005578 

Parallel elemental and molecular mass spectrometry analysis with laser ablation sampling


An apparatus for mass spectrometry includes a laser ablation sampler comprising a laser ablation chamber and a laser which produces a laser beam. The laser irradiates and ablates a material from a sample placed within the laser ablation chamber so as to generate an ablated sample material.
Westfaelische Wilhelms-universitaet Muenster


01/07/16
20160003836 

Photo or chemolabile conjugates for molecules detection


The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label..
Centre National De La Recherche Scientifique


01/07/16
20160003787 

Method and system for monitoring biomolecule separations by mass spectrometry


Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column.
Microsaic Systems Plc


01/07/16
20160002696 

Method to identify bacterial species by means of gas chromatography/mass spectrometry in biological samples


Method to identify bacterial classes in a biological sample, in particular a urine sample, that provides to carry out an analysis by means of gas chromatography-mass spectrometry (gc/ms) of the volatile components, such as metabolites and catabolites, of the sample in order to identify a graphic plot characteristic of a specific bacterial class.. .
Alifax Holding Spa


12/31/15
20150380230 

M/z targeted attenuation on time of flight instruments


A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a time of flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the time of flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity..
Micromass Uk Limited


12/31/15
20150380228 

An analytical apparatus utilizing electron impact ionization


An analytical apparatus (1) for mass spectrometry comprises an electron impact ioniser including an electron emitter (22) and an ionisation target zone (18). The target zone (18) is arranged to be populated with matter to be ionised for analysis.
Markes International Limited


12/31/15
20150377862 

Method to evaluate the tissue targeting of a molecule of interest


The invention relates to a method for evaluating if a molecule of interest binds or is incorporated in, at least one target tissue comprising visualizing and comparing the distribution of the molecule of interest and of at least one control compound within the target tissue or on the target tissue surface of at least one animal that has previously received the molecule of interest and/or the control compound. Advantageously, the distribution of the molecule of interest is visualized and compared with the distribution of positive and negative compounds using mass spectrometry imaging on the surface of the target tissue..
Imabiotech


12/31/15
20150377845 

Fully automated analytical determination of chloroethers in water and urine sample


A fully automated flow assisted-solid-phase microextraction (fa-spme) is developed for the determination of chloroethers in aqueous samples. A ctc combipal autosampler coupled with gas chromatography-mass spectrometry (gc-ms) is used to automate the extraction process.
King Abdulaziz City For Science And Technology


12/31/15
20150376678 

Srm assay to indicate cancer therapy


The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the alk, ros, ron, ret, ts, and/or fgfr1 proteins that are particularly advantageous for quantifying the alk, ros, ron, ret, ts, and/or fgfr1 proteins directly in biological samples that have been fixed in formalin by the methods of selected reaction monitoring (srm) mass spectrometry, or as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


12/24/15
20150371837 

Method and device for mass spectrometry


A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part.
Hitachi High-technologies Corporation


12/24/15
20150369818 

Her3 protein srm/mrm assay


The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the receptor tyrosine-protein kinase erbb-3, or her3, that are particularly advantageous for quantifying the her3 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


12/17/15
20150364315 

Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods


mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for differential background pressures where p2<p1 which generates gas flow through an unsealed, sealed or partially sealed ion trap and enhances detected signal relative to when p2=p1.. .
The University Of North Carolina At Chapel Hill


12/17/15
20150364311 

Compositions and methods for mass spectometry


The invention provides ionizing matrix compounds. These compounds are useful for mass spectrometry and ion mobility spectrometry as ionizing matrices facilitating transfer of diverse classes of analyte compounds from solid or solution states to gas-phase ions..

12/17/15
20150364307 

Systems and methods for single cell culture and analysis by microscopy and maldi mass spectrometry


Systems and methods for single cell culture and analysis by microscopy and matrix assisted laser desorption ionization mass spectrometry are disclosed. The systems and methods isolate a plurality of cells in a plurality of wells such that a predetermined number of the plurality of wells contain one and only one cell.
Massachusetts Institute Of Technology


12/17/15
20150364305 

Data processing for multiplexed spectrometry


Multiplexed spectrometry, such as multiplexed ion mobility spectrometry (ims), time-of-flight mass spectrometry (tofms), or hybrid im-tofms, is carried out on a sample, and the resulting measurement data are deconvoluted. Noise may be removed from the measurement data prior to deconvolution.
Agilent Technologies, Inc.


12/17/15
20150364302 

Optimizing drag field voltages in a collision cell for multiple reaction monitoring (mrm) tandem mass spectrometry


A collision cell has a plurality of rod electrodes arranged in opposed pairs around an axial centerline and a plurality of drag vanes arranged in the interstitial spaces between the rod electrodes. Operating the collision cell includes, applying a rod offset voltage to the rod electrodes, and varying an offset voltage applied to the drag vanes to identify a vane offset voltage with a maximum intensity for the transition.
Thermo Finnigan Llc


12/17/15
20150362504 

Quantitative peptide or protein assay


Peptide and/or protein quantitation methods, kits, and compositions, particularly useful for mass spectrometry, are provided herein based on a bathocuproine-based composition complex such as bathocuproinedisulfonic acid disodium salt hydrate complex. The methods are one-step rapid absorbance methods using small sample volumes.
Pierce Biotechnology, Inc.


12/10/15
20150357636 

Secondary battery-use active material, secondary battery-use electrode, secondary battery, battery pack, electric vehicle, electric power storage system, electric power tool, and electronic apparatus


A secondary battery includes: a cathode; an anode; and an electrolytic solution. The cathode contains an active material capable of inserting and extracting an electrode reactant.
Sony Corporation


12/10/15
20150357173 

Laser ablation atmospheric pressure ionization mass spectrometry


In an embodiment, the present invention provides an apparatus for mass spectrometry which includes a laser ablation sampler comprising a laser ablation chamber and a laser. The laser ablation chamber is configured so that the laser can irradiate and ablate a material from a sample to generate an ablated sample material.
WestfÄlische Wilhelms-universitÄt MÜnster


12/10/15
20150355193 

Methods of validating candidate compounds for use in treating copd and other diseases


The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (copd), chronic bronchitis, emphysema, refractory asthma, and other related diseases.
The Trustees Of Columbia University In The City Of New York


12/03/15
20150348768 

Combustion pretreatment-isotope dilution mass spectrometry


Provided is a combustion pretreatment-isotope dilution mass spectrometry measuring concentration of a target element for detection contained in a target sample for detection by using an isotope dilution mass spectrometry, including: pretreating the target sample for detection by combustion during an isotope dilution mass spectrometry, to thereby stabilize an isotope and further improve analysis ability, and therefore, the present invention is expected to be utilized as an element analysis method surpassing accuracy of the existing mass spectrometry method.. .
Korea Research Institute Of Standards And Science


12/03/15
20150348767 

Imaging mass spectrometry


A method of performing imaging mass spectrometry of a sample. The method comprises performing a first mass analysis of the sample using a first mass analyzer comprising a multi-pixel ion detector to obtain first mass spectral data representative of pixels of the sample.
Thermo Fisher Scientific (bremen) Gmbh


12/03/15
20150346214 

Detection of membrane proteins


According to the present invention, there is provided a method of detecting a membrane protein by mass spectrometry, the method comprising the steps of: (a) providing a solution comprising a detergent micelle in which said membrane protein is contained, wherein said solution contains a polyoxyalkylene glycol detergent; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the micelle; (d) ionising the membrane protein; (e) resolving the ionised membrane protein using the mass analyser; and (f) detecting the resolved membrane protein using the detector. Also provided are reagents for use in said method..

12/03/15
20150346183 

C peptide detection by mass spectrometry


Methods are described for measuring the amount of c peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying c peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
Quest Diagnostics Investments Incorporated


12/03/15
20150346152 

Mass spectrometry analyses on lipid and other ions using a unique workflow


The applicants' teachings provide in some aspects methods and apparatus for mass spectrometric analysis that identify the location of carbon-carbon double bonds, if any, in an analyte by (1) obtaining the m/z ratio of the intact analyte ions, (2) subjecting these ions to collision-induced dissociation and (3) determining relationships between masses and/or mass-to-charge ratios of the intact analyte ions and the fragments produced by such collision-induced dissociation. The methods and apparatus selectively subject analyte ions to ozone-induced dissociation based on those relationships and determine location(s) of carbon-carbon double bonds, if any, from reaction products of ozone-induced dissociation..
Unversity Of Wollongong




Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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