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Mass Spectrometry patents

This page is updated frequently with new Mass Spectrometry-related patent applications. Subscribe to the Mass Spectrometry RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometry RSS RSS

Ion guide for mass spectrometry

Dh Technologies Development Pte.

Ion guide for mass spectrometry

Mass spectroscope and mass spectrometry


Mass spectroscope and mass spectrometry

Mass spectroscope and mass spectrometry

Thermo Fisher Scientific (bremen)

Parallel mass analysis

Date/App# patent app List of recent Mass Spectrometry-related patents
 Laser desorption ionization mass spectrometry using a particulate separation bed patent thumbnailLaser desorption ionization mass spectrometry using a particulate separation bed
A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (maldi) for use with a mass spectrometer.
Purdue Research Foundation

 Ion guide for mass spectrometry patent thumbnailIon guide for mass spectrometry
An ion guide is provided having an enclosure extending longitudinally around a central axis from a proximal inlet end to a distal outlet end. The proximal inlet end receives a plurality of ions entrained in a gas flow through an inlet orifice.
Dh Technologies Development Pte. Ltd.

 Mass spectroscope and mass spectrometry patent thumbnailMass spectroscope and mass spectrometry
According to an embodiment, a mass spectroscope has a chamber, a charged particle beam source, a laser beam source, a mass spectrograph, and an optical system. The chamber accommodates a sample.
Kabushiki Kaisha Toshiba

 Parallel mass analysis patent thumbnailParallel mass analysis
A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device.
Thermo Fisher Scientific (bremen) Gmbh

 Methods and  increased ion throughput in tandem mass spectrometers patent thumbnailMethods and increased ion throughput in tandem mass spectrometers
In a tandem mass spectrometry system, a first mass analyzer filters parent ions using a wide mass passband with a narrow rejection notch defined according to a modulation format. A wide mass range of parent ions is transmitted to an ion fragmentation device.
Agilent Technologies, Inc.

 Mass spectrometry assay for congenital adrenal hyperplasia patent thumbnailMass spectrometry assay for congenital adrenal hyperplasia
Methods are provided for detecting the amount of one or more cah panel analytes (i.e., pregnenolone, 17-oh pregnenolone, progesterone, 17-oh progesterone, dehydroepiandrosterone (dhea), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more cah panel analytes in a sample and quantifying the generated ions to determine the amount of one or more cah panel analytes in the sample.
Quest Diagnostics Investments Incorporated

 Methods for diagnosing pulmonary hypertension patent thumbnailMethods for diagnosing pulmonary hypertension
Hypoxia induced mitogenic factor (himf) is a member of the “found in inflammatory zone” (fizz)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown.
The Johns Hopkins University

 Mass spectrometry method using matrix additive patent thumbnailMass spectrometry method using matrix additive
Where r represents an alkyl group having 4 to 14 carbon atoms; and irradiating the mixed crystal with laser to detect the sample to be analyzed.. .

 Sputter neutral particle mass spectrometry apparatus patent thumbnailSputter neutral particle mass spectrometry apparatus
A sputter neutral particle mass spectrometry apparatus includes a sample table holding a sample which is a mass spectrometry target, an ion beam irradiation device which irradiates an ion beam on the sample held by the sample table to generate neutral particles in an adjacent region of the sample, a light beam irradiation device which irradiates a light beam on the neutral particles positioned in the adjacent region to obtain photoexcited ions, a draw-out electrode which draws out the photoexcited ions, a mass spectrometer which draws in the drawn out photoexcited ions to perform mass analysis, and an optical element which is provided in a light path after the light beam passes the adjacent region, and changes a traveling direction of the light beam so that the light beam passes the adjacent region again.. .
Kabushiki Kaisha Toshiba

 Sputter neutral particle mass spectrometry apparatus patent thumbnailSputter neutral particle mass spectrometry apparatus
A sputter neutral particle mass spectrometry apparatus includes a sample table holding a sample which is a mass spectrometry target, and comprising a temperature control mechanism for the sample, an ion beam irradiation device which irradiates an ion beam on the sample to generate neutral particles, a laser irradiation device which irradiates the neutral particles with a laser to obtain photoexcited ions, a mass spectrometer which draws in the drawn out photoexcited ions and performs mass analysis, a driving system mirror which is provided retractably on a laser light path between the laser irradiation device and the sample table, and reflects the laser when positioned within the laser light path, and, a profiler which is arranged in a reflective direction of the driving system mirror and detects a feature of the laser.. .
Kabushiki Kaisha Toshiba


Ambient sampling mass spectrometry and chemometric analysis for screening encapsulated electronic and electrical components for counterfeits

A method and apparatus for identification of a counterfeit electronic component, subjecting a suspected counterfeit electronic to an analytical method of ambient surface analysis to desorb and ionize compounds directly from a suspected counterfeit electronic surface with no pretreatment, detecting the resultant ions, comparing the identified ions to known standards, and returning a confidence that the suspected counterfeit electronic being analyzed is counterfeit.. .
United States Of America As Represented By The Secretary Of The Navy


Mass spectrometer

An equation expressing a previously and experimentally determined relationship between the number of ions and a cv value is stored in a reference cv value calculation data memory. When mass spectrometry is performed for a target sample under measurement conditions including a loop time tp and a dwell time td, a chromatogram creator creates a chromatogram based on the analysis result and calculates a peak area value a.
Shimadzu Corporation


Mass spectrometer

An object of the present invention is to provide a mass spectrometer having a simple structure and being capable of precisely measuring a total pressure and performing mass spectrometry with high precision. A mass spectrometer according to one embodiment includes a quadrupole configured to selectively pass therethrough an ion of a target gas having a predetermined mass-to-charge ratio among components of a measurement gas ionized by an ion source, an ion detector configured to detect an ion current value based on the ion of the target gas that passes through the quadrupole, a total pressure measurer configured to detect a photoelectric current value based on vacuum ultraviolet light generated when the ion source ionizes the measurement gas, and an arithmetic unit configured to calculate a partial pressure of the target gas by using the photoelectric current value and the ion current value..
Canon Anelva Corporation


Non-thermal plasma jet device as source of spatial ionization for ambient mass spectrometry and application

The present invention relates to a non-thermal plasma jet device as spatial ionization source for ambient mass spectrometry of the type which allows a free adjustment of the geometry of the plasma beam, wherein the device comprises a double dielectric barrier probe of non-thermal plasma or ntp probe, which generates a non-thermal plasma jet; a high voltage and high frequency transformer circuit that connects an outer electrode through which it is possible to perform a discharge for the ionization of a gas which produces plasma, and wherein said plasma generator circuit is in turn connected to a source of ac power; an inner electrode which is grounded and allows to perform the discharge for the production of plasma; a storage tank of a gas serving as discharge gas; a test sample on which the non-thermal plasma jet is applied; and a ion transfer adapter to direct the ions produced by the device from the vacuum-free sample into a mass analyzer. The device described allows to directly analyzing live samples (plants, for example) without causing any damage to them..
Centro De InvestigaciÓn Y De Estudios Avanzados Del Instituto Ploitecnico Nacional


Method and ion mobility spectrometry

Methods and systems for performing mass spectrometry are provided herein. The method includes ionizing one or more compounds to generate ions, passing the ions into an ion mobility spectrometer, providing ozone, reacting the ions with ozone to produce ozone-induced fragment ions, and performing mass analysis and detection of the ozone-induced fragment ions.
University Of Wollongong


Drilling fluid analysis using time-of-flight mass spectrometry

An example method for analyzing drilling fluid used in a drilling operation within a subterranean formation may comprise placing a tof-ms in fluid communication with a drilling fluid. The drilling fluid may be flowing through a fluid conduit coupled to a drilling assembly.
Halliburton Energy Services, Inc.


Ion trap-based analyzing and detecting bipolar ion

An ion trap-based device and method for analyzing and detecting bipolar ions is provided. The device includes multiple electrodes of an ion trap; a radio frequency voltage source configured to form a radio frequency electric field; a direct current voltage source configured to form a bias electric field, positive and negative ions in the ion trap being separated by the bias electric field; a first and second detectors, configured to detect the positive and negative ions, respectively.
Beijing Institute Of Technology


Apparatus and methods for microbiological analysis

Methods and systems for identification of microorganisms either after isolation from a culture or directly from a sample. The methods and systems are configured to identify microorganisms based on the characterization of proteins of the microorganisms via high-resolution/mass accuracy single-stage (ms) or multi-stage (msn) mass spectrometry.
Oxoid Limited


Quantification of tau in biological samples by immunoaffinity enrichment and mass spectrometry

The present invention provides a quantitative immunoaffinity lc-ms/ms assay for detection and quantification of tau protein in a biological sample.. .
Merck Sharp & Dohme Corp.


Systems and methods for acquiring data for mass spectrometry images

Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.


Active material, electrode, secondary battery, battery pack, electric vehicle, electric power storage system, electric power tool, and electronic apparatus

A secondary battery includes: a cathode; an anode including an active material; and an electrolytic solution, wherein the active material includes a central section and a covering section provided on a surface of the central section, the central section includes silicon (si) as a constituent element, the covering section includes carbon (c) and hydrogen (h) as constituent elements, and one or more of positive ions represented by cxhy (x and y satisfy 2≦x≦6 and 3≦x≦9) are detected by positive ion analysis of the covering section with the use of time-of-flight secondary ion mass spectrometry.. .
Sony Corporation


Mass spectrometric quantitation

Provided is a method of assaying for an analyte, including combining a test sample having the analyte, with a calibration sample having at least two different aliquots of the analyte, each aliquot having a different known quantity of the analyte. The test sample and each aliquot are differentially labeled with one or more isobaric mass labels each with a mass spectrometrically distinct mass marker group, such that the test sample and each aliquot of the calibration sample can be distinguished by mass spectrometry.
Electrophoretics Limited


Conical multi-well filter plate

The present invention relates to a multi-well filter plate able to facilitate, simplify and accelerate preparation and treatment of samples to be analyzed by for example liquid chromatography tandem mass spectrometry (uplc—ms/ms method for simultaneous quantification of analytes).. .
Centre Hospitalier Universitaire Vaudois


Systems and methods for automated analysis of output in single particle inductively coupled plasma mass spectrometry and similar data sets

The present disclosure provides methods and systems for automated analysis of spectrometry data corresponding to particles of a sample, such as large data sets obtained during single particle mode analysis of an inductively coupled plasma mass spectrometer (sp-icp-ms). Techniques are presented herein that provide appropriate smoothing for rapid data processing without an accompanying reduction (or with an acceptably negligible reduction) in accuracy and/or precision..
Perkinelmer Health Sciences, Inc.


Ion trap mass spectrometer and ion trap mass spectrometry method

There are provided an ion trap mass spectrometer and an ion trap mass spectrometry method which can realize reduction of the number of times that a sample is ionized, and shortening of the measurement time. Ions corresponding to a plurality of peaks p11, p12 and p13 with the intensity or s/n ratio falling within a predetermined range l are detected as ms2 precursor ions based on the ms1 spectrum.
Shimadzu Corporation


Method and system for quantitative and qualitative analysis using mass spectrometry

In some embodiments, a quantitative analysis of at least one ion signal associated with a sample, which is detected by a mass spectrometer having at least two tandem quadrupole instruments, is employed to select one of the following operational modes for further mass analysis of the sample: (a) utilizing both quadrupole instruments as mass resolving filters, and (b) utilizing one quadrupole instrument as a mass resolving filter and utilizing the other as a linear ion trap. In some embodiments, the quantitative analysis of the ion signal comprises comparing the ion signal intensity with a predefined threshold..
Dh Technologies Development Pte. Ltd.


Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry

Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates—synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites in living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, by using existing mass spectrometric profiling techniques and art well known in the fields of static proteomics and static organeomics, without the need for additional biochemical preparative steps or analytic/instrumental devices..
The Regents Of The University Of California


High sensitivity electrospray interface

The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry.
University Of Notre Dame Du Lac


Analysis of ubiquitnated polypeptides

The disclosure relates to antibody reagents that specifically bind to peptides carrying a ubiquitin remnant from a digested or chemically treated biological sample. The reagents allow the technician to identify ubiquitinated polypeptides as well as the sites of ubiquitination on them.
Cell Signaling Technology, Inc.


Methods of preparation and manufacture of biocompatible solid-phase microextraction coatings and coated devices

Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the investigation of living systems. A number of interfaces to analytical instrumentation are disclosed including mass spectrometry, lc/ms, maldi and ce as well as direct spectroscopic on-fibre measurement..


Quadrupole mass spectrometry apparatus

A quadrupole mass spectrometry apparatus including a quadrupole power supply unit, in which the frequency of the high frequency voltage produced by a high frequency power supply is made switchable, and variable capacitors are provided in parallel with the floating capacitance of a quadrupole mass filter. In a high sensitivity mode which prioritizes sensitivity, the frequency of the high frequency voltage is made higher than in a high mass mode which prioritizes width of mass range, and the capacitance values of variable capacitors are increased.
Shimadzu Corporation


Ion guide

An ion guide for mass spectrometry comprising an electrode arrangement of at least two electrodes, at least one of which is an rf electrode, arranged adjacent to each other but spaced apart on a planar surface of a dielectric material and arranged at a distance from an ion flow path, wherein a portion of the dielectric surface is exposed between an adjacent pair of the spaced apart electrodes and wherein at least one electrode of said adjacent pair of electrodes is arranged to overhang the exposed portion of surface between them such that there is no direct line of sight from the ion flow path to the exposed portion of dielectric surface. The device enables rf guiding of ions accompanied by much reduced charging-up of dielectric surfaces and reduced amount of collisions of neutral species with electrodes..
Thermo Fisher Scientific (bremen) Gmbh


Mass spectrometer

Every time a target sample is injected from an injector (12) of an lc unit (1) and a mass spectrometry for a target component in the sample is performed, a cd voltage applied to a conversion dynode of an ion detector (29) is switched. For each of the multiple cd-voltage levels, a data collector (32) collects noise data during a period of time where no component is present and intensity data of an ion originating from the target component, while the sn ratio calculator (33) calculates an sn ratio.
Shimadzu Corporation


Mass spectrometer and mass spectrometry method

There are provided a mass spectrometer and a mass spectrometry method which can realize shortening of the measurement time and reduction of the consumption of a sample. Ions, in which the intensity distribution forms a peak waveform at both of each retention time and each mass-to-charge ratio (peaks p11, p21, p22 and p32) are detected as ms/ms precursor ions based on three-dimensional information of a retention time, a mass-to-charge ratio and an intensity.
Shimadzu Corporation


Setting ion detector gain using ion area

A control system and method of determining a signal to noise (s/n) ratio of an ion detector system, including an ion detector, electron multiplier or photomultiplier, operates by determining an area of a noise peak, determining an area of a signal peak and determining a ratio of the area of the signal peak to the area of the noise peak. Based thereon, the signal to noise ratio can be optimised.
Micromass Uk Limited


Diagnostic assay for alzheimer's disease

The present invention relates to the field of alzheimer's disease (ad). More specifically, the present invention provides methods and compositions useful in diagnosing and assessing ad.
The Johns Hopkins University


Sensitive measuring cis-diol containing compounds in plasma using 2d-lc-ms/ms

The present invention provides methods for determining the amount of cis-diol containing compounds in a biological samples using mass spectrometry, particularly catecholamines (dopamine, epinephrine, norepinephrine) in a plasma sample. After a sample is mixed with an internal standard, extracted with a two-step liquid-liquid extraction process utilizing phenylboronic acid chemistry, and then derivatized with a benzoyl chloride-like agent, relevant moieties are then separated chromatographically and detected by ms/ms whereby specific ion transitions are monitored.
National Medical Services, Inc.


Detection method and facility for checking sealed products for leaks

The invention concerns a detection method for checking sealed product packages for leaks, characterised in that it comprises the following steps: at least one previously sealed product (2) is placed in an air, nitrogen, or oxygen atmosphere, in a chamber (3) (step 101), the pressure in the chamber (3) is lowered to a secondary vacuum pressure below 10−1 mbar and, while continuing the secondary vacuum pumping of the chamber (3), the gases contained in the chamber are ionised to monitor the change in the chamber (3) of the concentration of at least one gaseous species of the gas volume contained within the sealed product (2) chosen from among nitrogen, oxygen, or argon, by analysis by optical emission or mass spectrometry (step 102).. .
Adixen Vacuum Products


Techniques for performing mass spectrometry

Techniques are described for performing mass spectrometry. A quadrupole, or more generally, an electrode-based device, performs mass filtering for selectively filtering ions.
Waters Technologies Corporation


Method and system for the quantitative chemical speciation of heavy metals and other toxic pollutants

This invention relates to systems and methods for measuring quantitatively multiple species or heavy metals, including mercury, and other toxic pollutants. More specifically, the systems and methods of the invention allows for determination of the analytes even at very low concentration, through concentration on a collection interface, desorption and analysis by mass spectrometry.


Method for detecting at least one mechanism of resistance to glycopeptides by mass spectrometry

The present invention relates to a method of detection, for at least one microorganism contained in a sample, of at least one marker of resistance to a glycopeptide, including the detection, by mass spectrometry, of at least one peptide or protein of said microorganism. Preferably, the glycopeptide is vancomycin.


Sample collection in compact mass spectrometry systems

mass spectrometry systems include a core featuring an ion source, an ion trap, and an ion detector connected along a gas path, a pressure regulation subsystem connected to the gas path and configured to regulate a gas pressure in the gas path, a sample pre-concentrator connected to the gas path, where the sample pre-concentrator includes an adsorbent material, and a controller connected to the sample pre-concentrator, where during operation of the system, the controller is configured to heat sample particles adsorbed on the adsorbent material to desorb the particles from the adsorbent material and introduce the desorbed particles into the gas path, and a pressure difference between a gas pressure in the sample pre-concentrator and a gas pressure in at least one of the ion source, the ion trap, and the ion detector when the desorbed particles are introduced into the gas path is 50 mtorr or less.. .
908 Devices Inc.


Automated microextraction technique for the analysis of n-nitrosoamines in water

An automated headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry for the determination of four n-nitrosoamines in groundwater samples is developed. Response surface methodology technique was employed to investigate the optimized extraction conditions of headspace solid-phase microextraction using combipal autosampler.
King Fahd University Of Petroleum And Minerals


Tandem time-of-flight mass spectrometry with non-uniform sampling

A method and apparatus are disclosed for parallel all-mass tandem mass spectrometry employing multi-reflecting time-of-flight analyzer for both ms stages, preferably arranged within the same analyzer to secure ultra-high resolution. Sensitivity and speed of tof-tof tandem are enhanced by non-redundant multiplexing based on signal sparseness and on avoiding repetitive signal overlaps at multiple repetitions of true fragment signals.
Leco Corporation


Method and analyzing biomolecules using raman spectroscopy

The present invention provides an apparatus having a sample separation unit, a raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of raman spectroscopy and mass spectrometry.
Japan Science And Technology Agency


Method for detecting susceptibility of microorganisms to chemical agents

A method for detecting susceptibility of microorganisms to chemical agents or antibiotics through a combination of exposing the microorganisms to the chemical agents or antibiotics after having exposed the microorganisms to a stress response-inducing stimulus and subsequently analyzing the response of the microorganisms by mass spectrometry.. .
Idmic Sa


Pulse-burst assisted electrospray ionization mass spectrometer

The present invention relates to a mass spectrometer system, which combines laser desorption with pulse bursts comprising a train of ultrashort pulses and electrospray ionization. The pulse separation between individual pulses within the pulse burst is selected such that transient phenomena on an irradiated sample do not fully relax between individual pulses.
Imra America, Inc.


Method to generate data acquisition mass spectrometry

A process for automatically creating a measurement method suitable for plasma ion source mass spectrometry, including: semi-quantitatively measuring all elements in the sample that affect the measurement; determining a plasma condition based on the total concentration of the semi-quantitatively measured elements; for each of the semi-quantitatively measured elements, estimating signal strengths of the element and an interference component in the sample to be measured and based on the resultant estimates, estimating the concentration of the element; and, based on the estimated signal strengths of the elements and the interference components and the estimated concentrations of the elements, creating at least one mass spectrometry method including at least one of: (1) a plasma condition; (2) an internal standard to be added to the sample; (3) a tuning condition for the collision/reaction cell; (4) a mass-to-charge ratio used in the mass spectrometer; and (5) an integration time used in the mass spectrometer.. .
Agilent Technologies, Inc.


Mass spectrometer

Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer..
Hitachi High-technologies Corporation


Mass spectrometry data display device and mass spectrometry data display program

A mass spectrometry data display device in which the mass axis (m/z axis) is made into a ring shape and the intensity axis is the radial direction thereof, and peak information (in the drawing, the compound name and structural formula candidates) are arranged in a ring shape in correspondence with the peaks along the outer circumference of the mass spectrum and displayed together therewith on a screen.. .
Shimadzu Corporation


High voltage power supply filter

Systems, devices, circuits, and methods are provided for an improved mass spectrometry detection system that comprises at least one component that operates at a high voltage. A number of high voltage filters or circuits are provided for reducing noise from high voltage power supplies that produce positive and negative voltages.
Dh Technologies Development Pet. Ltd.


Method for mass spectrometer with enhanced sensitivity to product ions

A mass spectrometry method comprises: introducing a first portion of a sample of ions including precursor ions comprising a first precursor-ion mass-to-charge (m/z) ratio into a first mass analyzer; transmitting the precursor ions from the first mass analyzer to a reaction or fragmentation cell such that a first population of product ions are continuously accumulated therein over a first accumulation time duration; initiating release of the accumulated first population of product ions from the reaction or fragmentation cell; continuously transmitting the released first population of product ions from the reaction cell to a second mass analyzer; transmitting a portion of the released first population of product ions comprising a first product-ion m/z ratio from the second mass analyzer to a detector; and detecting a varying quantity of the product ions having the first product-ion m/z ratio for a predetermined data-acquisition time period after the initiation of the release.. .
Thermo Finnigan Llc


Methods and performing mass spectrometry

The present disclosure relates, in part, to ms apparatus, methods, and/or software, having improved selectivity, sensitivity, specificity, resolution, mass accuracy and dynamic range over conventional ms technologies. In particular, the technology relates to apparatus, methods, and/or software wherein a combination of in-source fragmentation, ion mobility separation, and/or time-aligned parallel (tap) sample ion fragmentations are utilized in mass spectrometry for the analysis of samples..
Waters Technologies Corporation


Trapping reagents for reactive metabolites screening

The present invention provides compounds of formula (i) and (ii): (i) (ii) wherein r1, r2, r4, r5, r6, x and n are as defined herein, and wherein r3 is hydrogen or a sulfur protecting group. Compounds of formula (i) and (ii), wherein r is hydrogen, may be useful in methods for detecting a reactive metabolite in a sample, e.g., wherein the metabolite is generated from the metabolism of a test compound, and wherein the metabolite and the compound of formula (i) or (ii) react to form a detectable adduct, e.g., detectable by mass spectrometry..
Biogen Idec Ma Inc.


Srm methods in alzheimer's disease and neurological disease assays

Provided herein are methods for developing selected reaction monitoring mass spectrometry (lc-srm-ms) assays.. .
Integrated Diagnostics, Inc.


Universal antigen retrieval compounds and methods of use

Provided herein are methods, compounds, mixtures and formulations of antigen retrieval agent useful in retrieving antigens and improving the detection of amino acids, peptides and proteins or epitopes thereon in a tissue fixed with aldehyde-based cross-linking agents. Contacting the fixed tissue with a solution of the aldehyde scavenging agent causes reactivity with the aldehyde moieties to retrieve antigens and improve detection of the amino acids, peptides and proteins or epitopes.
University Of Houston System


Multiplexed analyses of test samples

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule.
Somalogic, Inc.


Analytical laser ablation of solid samples for icp, icp-ms, and fag-ms analysis

This invention is improved laser ablation of solid samples analyzed by inductively coupled plasma (icp), icp mass spectrometry, or flowing afterglow mass spectrometry. A mirror-with-hole eliminates chromatic aberration in sample viewing and allows rad-hardening for radiation hot cell analysis of nuclear waste.


Method for analyzing sample components

Described herein is a method and system for on-line coupling of capillary isoelectric focusing (cief) to high-resolution mass spectrometry in which a sheath flow buffer comprising polar organic solvent and organic acid is used as both an immobilization solution for (cief) and an ionization solution for electrospray ionization (esi).. .
C/o University Of Notre Dame Du Lac


Fine structure, optical member, antireflection film, water-repellent film, substrate for mass spectrometry, phase plate, process for producing fine structure, and process for producing antireflection film

Provided are an antireflection film having a high antireflection effect and a production process therefor, an optical member excellent in antireflection effect, a water-repellent film having excellent water repellency, a substrate for mass spectrometry having high detection sensitivity, a high-accuracy phase plate, and a fine structure that can be used in the foregoing and a production process therefor. The fine structure is a structure, including multiple conical portions on a surface thereof, in which the conical portions have a mesostructure; and the mesostructure includes a structure having mesopores..
Canon Kabushiki Kaisha


Identification and quantification of intact glycopeptides in complex samples

Illustrative embodiments of methods and apparatus for identifying one or more intact glycopeptides in a sample are disclosed. According to one illustrative embodiment, a method may comprise receiving data representing a plurality of mass spectra obtained from mass spectrometry of the sample, scoring data representing each of the plurality of mass spectra against data associated with target glycopeptides, and identifying one or more intact glycopeptides in the sample based at least in part on the scoring of the data representing each of the plurality of mass spectra..
Texas Tech University System


Automatic amino acid sequencing of glycopeptide by y1 ions

Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation.
Academia Sinica


Identification of metabolites from tandem mass spectrometry data using databases of precursor and product ion data

Techniques for identifying metabolites in a sample may utilize observed precursor and product ion data obtained by subjecting the sample to tandem mass spectrometry (ms/ms). The techniques may include first accessing a database of precursor ion data to identify one or more matching candidate metabolites in the database that match the observed precursor ion data.
Premier Biosoft


User interfaces, displaying multi-dimensional data for ion mobility spectrometry-mass spectrometry

A user interface, and related systems and methods, are provided for displaying multi-dimensional spectrometric data obtained from ims-ms operations. The user interface displays such data in alternative data plots, such as drift spectra, mass spectra, and multi-dimensional maps.
Agilent Technologies, Inc.


Mass spectrometry apparatus

The mass spectrometry apparatus is constituted by a sample plate to which a measurement target substance is adhered, the sample plate being transparent to a laser beam; a support mount on which the sample plate is placed, a part of the support mount being a light transmitting portion that transmits a laser beam; a light irradiation unit that exposes the measurement target substance to a laser beam from the back side of the sample plate and is provided with a laser source that outputs a laser beam, a collecting lens that collects a laser beam onto the measurement target substance, and an aberration-correction mechanism that corrects aberration which occurs when the laser beams are collected; and a detector that detects the measurement target substance which has been desorbed from the surface of the sample plate and ionized, by being irradiated with a laser beam.. .
Fujifilm Corporation


Targeted analysis for tandem mass spectrometry

A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection tof device that separates ions into packets in accordance with their m/z.
Thermo Fisher Scientific (bremen) Gmbh


Mass spectrometer and mass image analyzing system

The mass spectrometer has a chamber in which a sample is disposed, an irradiation unit for emitting particles to the sample, and an extraction electrode which leads secondary ions emitted from the sample to a mass spectrometry unit, in which the irradiation unit switches a first mode of emitting primary ions for causing the secondary ions to be emitted from the sample and a second mode of emitting particles containing water molecules to be made to adhere to the sample and emits the particles to the sample.. .


Biomarkers for ovarian cancer: beta 2 microglobulin

The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer or non-ovarian cancer.
Vermillion, Inc.


Analyte mass spectrometry quantitation using a universal reporter

Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.. .


Mass spectrometry analysis of microorganisms in samples

The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
Purdue Research Foundation


Glycopeptide analyzer

The same sample s is analyzed using an ion-trap (it) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (tof) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an it mass spectrum and a tof mass spectrum from the measured results.
Shimadzu Corporation


Method of ms/ms mass spectrometry

A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to electron capture dissociation (“ecd”) at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected.
Micromass Uk Limited


Multiple solid phase micro-extraction thermal desorption ionization device, mass spectrometer and analytical mass spectrometry

A multiple solid phase microextraction (m-spme) thermal desorption ionization device which desorbs an analyte and moves it into an entry of a mass spectrometer for mass spectrometry analysis is provided. The device has a charge producing unit, a heating unit and a sampling unit.
National Sun Yat-sen University


Mass spectrometry quantitation of p450 isoforms in hepatocytes

A method for screening a drug for cytochrome p450 (cyp) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome p450 isoform. The isoforms can be selected from 2b6, 3a4, 1a2, and 3a5 isoforms.
Dh Technologies Development Pte. Ltd.


Retention index standards for liquid chromatography

A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (lc-ms) methods, more especially for lc-ms methods employing electrospray (esi) or atmospheric pressure chemical ionization (apci) ionization systems.. .
National Research Council Of Canada


Pulsed ion beam source for electrospray mass spectrometry

Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry.
Academia Sinica


Analysis of microbes by maldi mass spectrometry

The invention relates to methods for the mass spectrometric analysis of microbes, in particular to a transfer method of microbes that are required to be identified from agar plates onto mass spectrometric sample supports and their preparation for ionization by matrix-assisted laser desorption (maldi). Microbes from microcolonies which have grown on the agar plates after a culture time of only six to eight hours are transferred with a high transfer yield onto contact surfaces of suitable size by direct contact and cell disrupted on the contact surface; the released proteins are prepared with matrix material on the contact surface as maldi samples.
Bruker Daltonik Gmbh


Method of identifying precursor ions

A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analysing the fragment or product ions; determining the start and end times at which a first fragment or product ion is detected; using said start and end times to determine the start and end times at which a precursor ion of said first fragment or product ion is transmitted by said mass analyser; and using the start and end times at which the precursor ion is transmitted by said mass analyser to determine a mass to charge ratio of said precursor ion. The present invention enables precursor ion peaks to be resolved from the fragment data even when a low resolution mass analyser is used to analyse the precursor ions..
Micromass Uk Limited


Systems and methods for using interleaving window widths in tandem mass spectrometry

Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


Mrm-ms signature assay

The present invention relates to mass spectrometry methods employing multiple reaction monitoring (mrm) in the field of cancer therapeutics, specifically prostate cancer and melanoma.. .


Tuned synthetic dendrimer calibrants for mass spectrometry

Provided are synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative ease and rapidity of synthesis, comparatively low cost, long shelf life, high purity, and amenability to batch synthesis as mixtures.


Mass spectrometry data processing device

A data processing device in which, on a screen where an ms spectrum for a retention time designated by the analyst is displayed in the upper area and an ms2 spectrum for a precursor ion selected automatically based on the ms spectrum is displayed in the lower area, when an “on” button in a precursor parameter display selection frame in the top part is clicked, excluded ion and priority ion information for that retention time is collected and the m/z ranges and are displayed in a specified display color on the ms spectrum. As a result, it becomes possible to see at a glance whether the precursor ion indicated by upward arrow corresponds to an excluded ion or priority ion..


Reducing interferences in isobaric tag-based quantification

Methods and systems for performing mass spectrometry of analytes labeled with isobaric tags are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can enable enhanced discrimination between an analyte of interest and one or more interfering species when using isobaric tagging techniques..


Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy

The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion.. .


Systems and methods for sequencing peptides by mass spectrometry

The number of atoms present in an ion of a molecule is identified using a mixture of different forms of the molecule. A mass spectrometer analyzes a mixture of at least two forms of the molecule using one or more ion scans producing a mass spectrum.


Systems and methods for using variable mass selection window widths in tandem mass spectrometry

Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.

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Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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