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Date/App# patent app List of recent Mass Spectrometry-related patents
04/10/14
20140099725
 Methods for the analysis of glycoproteins or glycopeptides by mass spectrometry patent thumbnailnew patent Methods for the analysis of glycoproteins or glycopeptides by mass spectrometry
A method for the analysis of samples including one or more glycopeptides including the steps of separating one or more glycopeptides using a chromatography system to produce a chromatographic eluent, adding a supercharging reagent to the chromatographic eluent, providing the chromatographic eluent and supercharging reagent to a mass spectrometer, ionizing said chromatographic eluent and supercharging reagent in an ion source to produce glycopeptide ions, performing at least one ion ion reaction on at least some of the glycopeptide ions to produce fragment ions, mass analyzing the fragment ions to produce ion ion reaction mass spectral data, and interpreting the ion ion reaction data mass spectral data to provide structural information relating to the glycopeptide.. .
04/03/14
20140094594
 Immunoaffinity isolation of modified peptides from complex mixtures patent thumbnailImmunoaffinity isolation of modified peptides from complex mixtures
The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (ms), tandem mass spectrometry (ms-ms), and/or ms3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide.
04/03/14
20140093968
 Method for highly multiplexed quantitation of peptides by mass spectrometry and mass labels therefor patent thumbnailMethod for highly multiplexed quantitation of peptides by mass spectrometry and mass labels therefor
Disclosed herein are isobaric labeling reagent sets useful for multiplexed quantitation of peptides. The isobaric labeling reagent sets include a collection of at least two isobaric labeling reagents having first and second reporter groups with the same nominal mass but different isotopic substitutions and consequently different exact masses.
04/03/14
20140093899
 Thyroglobulin quantitation by mass spectroscopy patent thumbnailThyroglobulin quantitation by mass spectroscopy
Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample..
04/03/14
20140090199
 Cleaning sheet, carrying member with a cleaning function and method of cleaning substrate processing equipment patent thumbnailCleaning sheet, carrying member with a cleaning function and method of cleaning substrate processing equipment
A cleaning sheet comprising a cleaning layer and a releasable protective film laminated on the cleaning layer, wherein each of the relative intensities of the fragment ions of ch3si+, c3h9si+, c5h15si2o+, c5h15si3o3+, c7h21si3o2+, ch3sio−, ch3sio2− and si+ in the cleaning layer, when the protective film is peeled off the cleaning layer, is 0.1 or less according to time-of-flight secondary ion mass spectrometry, relative to c2h3+ in the case of positive ion or o− in the case of negative ion.. .
04/03/14
20140090196
 Cleaning sheet, carrying member with a cleaning function and method of cleaning substrate processing equipment patent thumbnailCleaning sheet, carrying member with a cleaning function and method of cleaning substrate processing equipment
A cleaning sheet comprising a cleaning layer and a releasable protective film laminated on the cleaning layer, wherein each of the relative intensities of the fragment ions of ch3si+, c3h9si+, c5h15si2o+, c5h15si3o3+, ch3sio−, ch3sio2− and si+ in the cleaning layer, when the protective film is peeled off the cleaning layer, is 0.1 or less according to time-of-flight secondary ion mass spectrometry, relative to c2h3+ in the case of positive ion or o− in the case of negative ion.. .
03/27/14
20140088885
 Method, an apparatus, and a computer program product for identifying metabolites from liquid chromatography-mass spectrometry measurements patent thumbnailMethod, an apparatus, and a computer program product for identifying metabolites from liquid chromatography-mass spectrometry measurements
The present invention relates to a method for identifying metabolites present in a set of samples. The method may include: (a) forming a plurality of peak-groups, wherein each peak-group comprises mass peaks representative of a specific ion in each chromatographic run; (b) forming a plurality of clusters, wherein each cluster comprises at least one peak-group of (a) each having similar chromatographic profiles; and (c) generating a list of metabolite predictions, wherein each metabolite prediction is selected from the plurality of clusters of (b)..
03/27/14
20140088884
 Methods of source attribution for chemical compounds patent thumbnailMethods of source attribution for chemical compounds
Methods of determining the source of an unknown sample are disclosed. Mass spectra from possible sources are obtained using two-dimensional gas chromatography coupled with time-of-flight mass spectrometry.
03/27/14
20140087408
 Information acquisition method patent thumbnailInformation acquisition method
The present invention relates to an information acquisition method of acquiring information of distribution of a protein or peptide in a sample based on mass information obtained by mass spectrometry of the protein or peptide. The method includes mass spectrometry of a definite region of the sample after limited proteolysis of the protein or peptide and acquisition of information relating to distribution using an ion peak that has a two-dimensional intensity distribution having a pearson product-moment correlation coefficient of 0.5 to more and 1.0 or less in the definite region against the two-dimensional intensity distribution of the parent ion of the protein or the peptide subjected to the limited proteolysis and has a peak intensity ratio of larger than 1.0 against the peak intensity of the integrated spectrum of the parent ion in the definite region, wherein the m/z of the ion peak is greater than 500..
03/27/14
20140084156
 Radio frequency (rf) ion guide for improved performance in mass spectrometers at high pressure patent thumbnailRadio frequency (rf) ion guide for improved performance in mass spectrometers at high pressure
Ion guides for use in mass spectrometry (ms) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (dc or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range.
03/27/14
20140084153
Nanoparticulate assisted nanoscale molecular imaging by mass spectrometery
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source..
03/27/14
20140084152
Matrix additive for mass spectrometry
Where r is an alkyl group having 6 to 10 carbon atoms and the substituted carboxyl group and hydroxyl group are ortho or meta to each other. A matrix additive for mass spectrometry, which is represented by the above formula (i).
03/27/14
20140084151
Matrix assisted laser desorption ionisation mass spectrometry imaging (maldi-msi)
A method of preparing a sample for matrix assisted laser desorption ionisation mass spectrometry imaging analysis by a two-step process. Firstly, a maldi matrix is dusted on to the sample followed by a spray of a suitable solvent onto the dusted sample.
03/20/14
20140080151
Anti-himf antibodies to treat lung diseases
Hypoxia induced mitogenic factor (himf) is a member of the “found in inflammatory zone” (fizz)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown.
03/13/14
20140072991
Quantitative standard for mass spectrometry of proteins
Furthermore provided is a fusion polypeptide for the quantification of a target polypeptide by mass spectroscopy, wherein: said fusion polypeptide consists of 35 to 455 amino acid residues and comprises (i) a target region, which is a fragment of the target polypeptide, and (ii) a tag region, which is not a fragment of the target polypeptide, said target region consists of 15 to 205 amino acid residues and comprises at least two signature regions; said tag region consists of 20 to 250 amino acid residues and comprises at least two signature regions; and each signature region has the structure y-z-x4-28-y-z, wherein all y:s are selected from one of (i)-(iv), wherein (i) is r or k, (ii) is y, f, w or l, (iii) is e and (iv) is d and each x and each z are independently any amino acid residue, provided that the z:s are not p if the y:s are selected from (i)-(iii); and each signature region comprises at least one amino acid residue comprising a heavy isotope.. .
03/13/14
20140070086
Method for analyzing glycan structure
In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of cid energy; creating an energy-resolved profile including yield curves representing relationships between (i) a value of the cid energy and (ii) measured amounts of specific types of product ions; preparing a reference profile, and identifying a glycan structure of a test material by comparing the energy-resolved profile with the reference profile.. .
03/13/14
20140070085
Spinning cell device for fast standardization in laser ablation inductively coupled plasma spectrometry
A spinning cell device is described for fast and convenient standardization and analysis of constituents and isotopes in solid samples by laser ablation inductively coupled plasma (la-icp) spectrometry. The method and apparatus for performing he method require the sample under test and a standard to be spun during ablation allowing the quasi-simultaneous ablation of both materials.
02/27/14
20140057293
Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates
Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, and purifications.
02/20/14
20140051180
Synchronization of ion generation with cycling of a discontinuous atmospheric interface
The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface..
02/20/14
20140051176
Vitamin d metabolite determination utilizing mass spectrometry following derivatization
The invention relates to the detection of vitamin d metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin d metabolites by mass spectrometry..
02/20/14
20140051113
Apparatus and methods for microbiological analysis
Methods and systems for identification of microorganisms either after isolation from a culture or directly from a sample. The methods and systems are configured to identify microorganisms based on the characterization of proteins of the microorganisms via high-resolution/mass accuracy single-stage (ms) or multi-stage (msn) mass spectrometry.
02/20/14
20140051105
Mutant proteins as cancer-specific biomarkers
Altered protein products resulting from somatic mutations are directly identified and quantified by mass spectrometry. The peptides expressed from normal and mutant alleles are detected by selected reaction monitoring (srm) of their productions using a triple quadrupole mass spectrometer.
02/20/14
20140051067
Process for the detection and early serotyping of the dengue virus
Disclosed is a process for in vitro detection of an infection by a dengue virus in an individual, including the following steps: contacting a blood sample from the individual with a ligand specific to the ns1 protein of said dengue virus, to capture ns1 protein if it is present in the blood sample, said ligand being immobilized on a solid support; detecting the presence of ns1 protein via a mass spectrometry reading; and if ns1 protein is detected, concluding that the individual has been infected by dengue virus.. .
02/20/14
20140048705
Mass independent kinetic energy reducing inlet system for vacuum environment
A particle inlet system comprises a first chamber having a limiting orifice for an incoming gas stream and a micrometer controlled expansion slit. Lateral components of the momentum of the particles are substantially cancelled due to symmetry of the configuration once the laminar flow converges at the expansion slit.
02/20/14
20140048703
Methods for detecting vitamin c by mass spectrometry
Provided are methods for determining the amount of vitamin c in a sample using mass spectrometry. The methods generally involve ionizing vitamin c in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin c in the sample..
02/20/14
20140048701
Pre-scan for mass to charge ratio range
A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined.
02/20/14
20140048700
Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry
A method and apparatus to trap, release and/or separate sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current includes cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes.
02/20/14
20140048697
Ion generation using wetted porous material
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
02/20/14
20140047906
Lc-ms configuration for purification and detection of analytes having a broad range of hydrophobicites
Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (lc-ms). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (lc-ms) system.
02/13/14
20140045273
Methods and apparatus for identification of polymeric species from mass spectrometry output
Methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data corresponding to an unidentified chemical compound. By restricting the generation of candidate formulas to those having repeating units and/or end units with specified limitations, the methods and apparatus may more efficiently iteratively search for a chemical formula having matching mass spectrometry output within a threshold tolerance.
02/13/14
20140045064
Positive electrode active material, positive electrode using the same and non-aqueous electrolyte secondary battery
A positive electrode active material includes: a particle containing a positive electrode material capable of intercalating and deintercalating an electrode reactant; and a film provided in at least a part of the particle and having a peak of c2h5s+, c3h7s+ or c4h9s+ obtained by cation analysis by time of flight secondary ion mass spectrometry.. .
02/13/14
20140044673
Classifying skin lesions using mass spectrometry proteomic approach
The present invention provides for a mass spectrometry proteomic approach to distinguishing spitz nevi from spitzoid malignant melanoma. Histology directed mass spectral profiling allows for targeted analysis of sites of melanocytic lesion within formalin-fixed, paraffin embedded excisional biopsies.
02/13/14
20140042313
High sensitivity mass spectrometry systems
A high sensitivity desorption electrospray ionization mass spectrometry system that employs a heated platform, along with means for directing a liquid stream containing an analyte of interest onto a target location on the heated platform to heat the stream, an electrospray emitter for generating an electrospray and directing the electrospray at the target location on the heated platform to produce an ionized, desorbed analyte, and a mass spectrometer for receiving and detecting the ionized, desorbed analyte.. .
02/13/14
20140042312
M/z targeted attenuation on time of flight instruments
A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a time of flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the time of flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity..
02/06/14
20140038899
Biomarkers for ovarian cancer
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition.
02/06/14
20140038219
Thyroglobulin quantitation by mass spectrometry
Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample..
02/06/14
20140034828
Ion carpet for mass spectrometry having progressive electrodes
An ion transport apparatus for a mass- or ion-mobility-spectrometer comprises: (a) a plurality of strip electrodes in a series on a fiat substrate; (b) an ion outlet aperture in the substrate disposed adjacent to a first one of the plurality of strip electrodes; (c) a cage electrode at least partially enclosing the plurality of strip electrodes and the ion outlet aperture; (d) a radio frequency (rf) voltage generator operable to supply an rf phase difference between each pair of adjacent electrodes; and (e) at least one dc voltage source operable to supply first and second dc voltages to the cage electrode and an extraction electrode and to supply respective dc bias voltages to each of the plurality of electrodes, wherein electrode strip widths of a series of the plurality of electrodes progressively increase away from the first one of the plurality of electrodes.. .
01/30/14
20140030845
Semiconductor device and method for manufacturing the same
The amount of nitrogen that is transferred to an oxide semiconductor film of a transistor including the oxide semiconductor film is reduced. In addition, in a semiconductor device which includes a transistor including an oxide semiconductor film, change in electrical characteristics is suppressed and reliability is improved.
01/30/14
20140027631
Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum
Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry..
01/23/14
20140024052
Sequence-specific extraction and analysis of dna-bound proteins
An automated protein preparation technology that may use magnetic microparticles to isolate proteins in their native state from specific genomic loci of interest via the chromatin to which they are bound is described. After extraction, the targeted proteins may be purified for down-stream analysis by quantitative mass spectrometry or elisa.
01/16/14
20140017793
Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid
The invention relates to the detection of dha and epa. In a particular aspect, the invention relates to methods for detecting dha and epa by mass spectrometry and kits for carrying out such methods..
01/16/14
20140017716
Proteolytic digestion kit with dried reagents
Compositions and methods are provided for the rapid and efficient denaturation and degradation of protein samples. The compositions and methods produce samples that can readily be analyzed by, for example, mass spectrometry.
01/16/14
20140017564
Lithium-ion secondary battery, electrode for the secondary battery, and electrolytic copper foil for electrode for the secondary battery
To provide an electrolytic copper foil for a negative electrode for a lithium-ion secondary battery with which it is possible to produce a long-life lithium-ion secondary battery in which there is no decline in the capacity retention ratio even when the charge-discharge cycling is repeated, that has long life, and no deformation of a negative electrode current collector occurs. The electrolytic copper foil constituting the negative electrode current collector for the lithium-ion secondary battery has, after heat treatment at from 200 to 400° c., a 0.2% proof stress of 250n/mm2 or more, and elongation of 2.5% or more; and the surface on which an active material layer of the electrolytic copper foil is provided has been rust-proofed, or roughened and rust-proofed.
01/16/14
20140014832
Mass spectrometry assay for congenital adrenal hyperplasia
Methods are provided for detecting the amount of one or more cah panel analytes (i.e., pregnenolone, 17-oh pregnenolone, progesterone, 17-oh progesterone, dehydroepiandrosterone (dhea), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more cah panel analytes in a sample and quantifying the generated ions to determine the amount of one or more cah panel analytes in the sample.
01/09/14
20140012515
Chromatograph mass spectrometry data processing device
When an analyst designates an arbitrary component on a component table displayed in a component table display area, an eic of the characteristic mass in the vicinity of the retention time of the component is created and is displayed in a chromatogram display area. In addition, an actual measurement mass spectrum at the retention time of the designated component and a pure standard mass spectrum of the component are aligned vertically in the same mass axis scale and displayed in a mass spectrum display area.
01/09/14
20140008532
Ion generation using wetted porous material
The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent..
01/09/14
20140008530
Multipole ion guide interface for reduced background noise in mass spectrometry
Ions that are transported from an ion source to a mass spectrometer for mass analysis are often accompanied by background particles such as photons, neutral species, and cluster or aerosol ions which originate in the ion source. Background particles are also produced by scattering and neutralization of ions during collisions with background gas molecules in higher pressure regions with line-of-sight to the mass spectrometer detector.
01/09/14
20140008529
Ion generation using wetted porous material
The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent..
01/02/14
20140005970
Method of deadtime correction in mass spectrometry
A method of improving the fidelity of m/z dependent and/or intensity measurements for a species of interest in an analyte to correct for hardware limitations within a mass spectrometer, which method comprises the steps of acquiring raw data produced by a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent and/or intensity measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent and/or intensity measurements with associated uncertainties.. .
01/02/14
20140005954
Method of processing multidimensional mass spectrometry
A method of processing multidimensional data acquired from analytical equipment, which method comprises the steps of providing raw multidimensional data that includes mass spectrometric analytical data obtained from a sample, conducting a first processing step of identifying regions of interest within the raw multidimensional data and conducting a second processing step of refining the raw multidimensional data associated with the one or more regions of interest using peak detection of the mass spectrometric analytical data, wherein the first processing step is conducted using a first processing means and/or a first software program and the second processing step is conducted using a second processing means and/or a second software program, whereby the first and second processing steps are capable of independent implementation.. .
01/02/14
20140005282
Cmet protein srm/mrm assay
Specific peptides are provided, and derived ionization characteristics of those peptides, from the hepatocyte growth factor receptor (cmet) protein. The peptides are particularly and surprisingly advantageous for quantifying by the method of selected reaction monitoring (srm) mass spectrometry the cmet protein directly in biological samples that have been fixed in formalin, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry.
01/02/14
20140005074
Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates—synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites in living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, by using existing mass spectrometric profiling techniques and art well known in the fields of static proteomics and static organeomics, without the need for additional biochemical preparative steps or analytic/instrumental devices..
01/02/14
20140004616
Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples.
01/02/14
20140004530
Method for the evaluation of compound-target interactions across species
The present invention relates to a method for the determination of the species profile of a protein-interacting compound, comprising the steps of a) providing a protein preparation derived from one species (species-1) containing a species-1-variant of said protein, b) providing a protein preparation derived from another species (species-2) containing a species-2-variant of said protein, c) mixing said preparations, d) contacting said mixed protein preparations with a ligand of said protein and with a given protein-interacting compound under conditions allowing the formation of a complex between said ligand and said protein, and e) detecting the complexes formed in step d) with the help of mass spectrometry.. .
12/26/13
20130345093
Method for detection and quantification of target biomolecules
The invention relates to a method for detection and quantification of target biomolecules, such as dna, rna or proteins, using exogenous element labelling and dynamic secondary ion mass spectrometry.. .
12/26/13
20130344524
Analysis method
In a method for detecting a glucagon-secretin family peptide in a sample, the sample is contacted with a cleaving agent capable of digesting the glucagon-secretin family peptide by cleaving a peptide bond of at least one aspartic acid within the glucagon-secretin family peptide and thereby generating a plurality of peptide fragments, at least one of the peptide fragments containing an n-terminal end of the glucagon-secretin family peptide. The peptide fragment that contains the n-terminal end of the glucagon-secretin family peptide is then detected using liquid chromatography and mass spectrometry.
12/26/13
20130344111
Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
A method and system for predicting in advance of treatment whether a cancer patient is likely, or not likely, to obtain benefit from administration of a yeast-based immune response generating therapy, which may be yeast-based immunotherapy for mutated ras-based cancer, alone or in combination with another anti-cancer therapy. The method uses mass spectrometry of a blood-derived patient sample and a computer configured as a classifier using a training set of class-labeled spectra from other cancer patients that either benefitted or did not benefit from an immune response generating therapy alone or in combination with another anti-cancer therapy.
12/26/13
20130341279
Ionization method, mass spectrometry method, extraction method, and purification method
To achieve soft ionization more easily when a slight amount of substance is ionized under an atmosphere pressure. An ionization method for a substance contained in a liquid, including: supplying the liquid to a substrate from a probe and forming a liquid bridge made of the liquid containing the substance dissolved therein, between the probe and the substrate; oscillating the probe; and generating an electric field between an electrically conductive portion of the probe in contact with the liquid and an ion extraction electrode..
12/19/13
20130338935
Mass spectrometry data processing device
In the case where a peak on a mass spectrum is saturated due to, for example, signal saturation in a detector or an amplifier provided downstream thereof, a data processor performs fitting with a gaussian function using data included in the rising part and the falling part (range a) of the peak which are not affected by the saturation, to thereby obtain a desired approximate peak shape b. Then, a mass spectrum in which the saturated peak is replaced with the approximate peak thus obtained is created, the mass-to-charge ratio of the peak top is calculated for this mass spectrum, and this mass spectrum is then displayed on a display screen.
12/19/13
20130338029
Method for a highly sensitive detection and quantification of biomolecules using secondary ion mass spectrometry (sims) and related technologies
The present invention relates to a method for detecting and quantifying the presence or absence of a number of biomolecules in a sample using the sims technique and arrays for use in said method.. .
12/19/13
20130337502
Analysis of microbes from microcolonies by maldi mass spectrometry
The invention relates to the cell disruption of microbes and the preparation of the microbe proteins for mass spectrometric analysis. The cells of microbes from microcolonies are disrupted by physical or chemical means directly on the nutrient medium.
12/19/13
20130334414
Mass spectrometry for multiplexed quantitation using multiple frequency notches
A method of performing a mass spectrometry analysis includes labeling each of a plurality of samples with a corresponding chemical tag; forming a first plurality of ions from molecules in the samples; selecting a subset of the first plurality of ions, the subset being selected by isolating ions of the first plurality of ions in a plurality of ranges of mass-to-charge; forming a second plurality of ions by fragmenting ions in the subset; and measuring information indicative of a quantity of each of the plurality of chemical tags present in each of the plurality of samples.. .
12/19/13
20130334030
Ionization method, mass spectrometry method, extraction method, and purification method
The present invention has an object to achieve soft ionization more easily when a slight amount of substance is ionized under an atmosphere pressure. The present invention provides an ionization method for a substance contained in a liquid, including: supplying the liquid to a substrate from a probe and forming a liquid bridge made of the liquid containing the substance dissolved therein, between the probe and the substrate; oscillating the substrate; and generating an electric field between an electrically conductive portion of the probe in contact with the liquid and an ion extraction electrode..
12/12/13
20130330744
Nitrated cardiac troponin i as a biomarker of cardiac ischemia
Diagnosis and prognosis is conducted by determining the amount of nitrated cardiac troponin i in serum samples of subjects and the ratio of nitrated cardiac troponin i to non-nitrated cardiac troponin i in serum samples of subjects. This biomarker can be detected by immunoassay techniques and tandem mass spectrometry.
12/12/13
20130330714
Mass spectrometry analysis of microorganisms in samples
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
12/12/13
20130327934
Parallel mass analysis
A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device.
12/12/13
20130327647
Pretreatment device for dissolved ions analysis and dissolved ion analysis system
Provided is a pretreatment device for analysis of dissolved ions, which enables the separation of dissolved ions to be analyzed from a sample solution in a short period of time and which is applicable to both a case in which the dissolved ions to be measured is a cation and a case in which the dissolved ions to be measured is an anion. A pretreatment device 10 for analysis of dissolved ions, which comprises: a sample solution flow channel 11 through which a sample solution containing dissolved ions to be measured flows; an acceptor solution flow channel 13 which is arranged adjacent to the sample solution flow channel 11 so as to intercalate a dialysis membrane 12 between the acceptor solution flow channel 13 and the sample solution flow channel 11; a pair of electrodes 14a, 14b which are so arranged as to intercalate the sample solution flow channel 11 and the acceptor solution flow channel 13 therebetween; and a direct current power source 5 which enables the generation of a predetermined potential difference between the electrodes 14a, 14b.
12/05/13
20130325354
Computerized method for correlating and elucidating chemical structures and substructures using mass spectrometry
The present invention is directed to a computational method for correlating and elucidating a mass spectrum with one or more proposed chemical structures.. .
12/05/13
20130323849
Selective detection and analysis of small molecules
The invention relates to a material, process and method for the selective analysis of small molecules. Particularly the invention provides a material and a technique for the analysis of small molecules excluding other large molecular weight (mw) analytes.


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Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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