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This page is updated frequently with new Mass Spectrometry-related patent applications. Subscribe to the Mass Spectrometry RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometry RSS RSS


Bottom gate type thin film transistor, method of manufacturing the same, and display apparatus

Canon

Bottom gate type thin film transistor, method of manufacturing the same, and display apparatus

Date/App# patent app List of recent Mass Spectrometry-related patents
03/26/15
20150087073
 Methods for quantifying polypeptides using mass spectrometry patent thumbnailnew patent Methods for quantifying polypeptides using mass spectrometry
A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of comprising an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent comprising an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent comprising an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole..
Waters Technologies Corporation
03/26/15
20150084048
 Bottom gate type thin film transistor,  manufacturing the same, and display apparatus patent thumbnailnew patent Bottom gate type thin film transistor, manufacturing the same, and display apparatus
Provided is a bottom gate type thin film transistor including on a substrate (1) a gate electrode (2), a first insulating film (3) as a gate insulating film, an oxide semiconductor layer (4) as a channel layer, a second insulating film (5) as a protective layer, a source electrode (6), and a drain electrode (7), in which the oxide semiconductor layer (4) includes an oxide including at least one selected from the group consisting of in, zn, and sn, and the second insulating film (5) includes an amorphous oxide insulator formed so as to be in contact with the oxide semiconductor layer (4) and contains therein 3.8×1019 molecules/cm3 or more of a desorbed gas observed as oxygen by temperature programmed desorption mass spectrometry.. .
Canon Kabushiki Kaisha
03/19/15
20150080233
 Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry patent thumbnailMultiplexed imaging of tissues using mass tags and secondary ion mass spectrometry
A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (sims) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set.
The Board Of Trustees Of The Leland Stanford Junior University
03/19/15
20150079502
 Mask blank and  manufacturing a transfer mask patent thumbnailMask blank and manufacturing a transfer mask
Provided is a mask blank having a structure including a thin film on a substrate, wherein the thin film is made of a material containing one or more elements selected from tantalum, tungsten, zirconium, hafnium, vanadium, niobium, nickel, titanium, palladium, molybdenum, and silicon, and wherein the normalized secondary ion intensity of at least one or more ions selected from a calcium ion, a magnesium ion, and an aluminum ion is 1.0×10−3 or less when a surface of the thin film is measured by time-of-flight secondary ion mass spectrometry (tof-sims) under measurement conditions of a primary ion species of bi3++, a primary accelerating voltage of 30 kv, and a primary ion current of 3.0 na.. .
Hoya Corporation
03/19/15
20150076341
 Method of mass spectrometry and a mass spectrometer patent thumbnailMethod of mass spectrometry and a mass spectrometer
The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas..
Micromass Uk Limited
03/19/15
20150076340
 Mass spectrometric analysis using nanoparticle matrices patent thumbnailMass spectrometric analysis using nanoparticle matrices
Methods of characterizing an analyte of interest are provided. The methods can involve using a population of nanoparticles (e.g., magnetic ferrite nanoparticles) as a matrix for matrix-assisted laser desorption ionization (maldi) mass spectrometry.
The Board Of Trustees Of The University Of Alabama
03/12/15
20150073727
 Method and  improved quantitation by mass spectrometry patent thumbnailMethod and improved quantitation by mass spectrometry
A method of quantifying analytes from mass spectral data, comprising: obtaining a first set of mass spectral data from a first set of analytes eluted from a chromatography column; obtaining a second set of mass spectral data from a second set of analytes eluted from a chromatography column; determining apparent abundances of analytes in each data set; selecting a target analyte and determining localised neighboring analytes by their locality to the target analyte with respect to retention time; determining a locally corrected abundance of the target analyte based on differences between the first and second data sets in the apparent abundance of the localised neighboring analytes; and quantifying the target analyte based on its corrected abundance. A majority of the neighboring analytes are typically substantially unchanged in actual abundance between the first and second data sets and can be used for aligning the abundances between the data sets..
Thermo Fisher Scientific (breman) Gmbh
03/12/15
20150072895
 Srm/mrm assay for subtyping lung histology patent thumbnailSrm/mrm assay for subtyping lung histology
The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins that are particularly advantageous for quantifying the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.
03/12/15
20150069226
 Mass spectrometry  phosphorylated peptides and sugar chains patent thumbnailMass spectrometry phosphorylated peptides and sugar chains
The present invention provides a method for mass spectrometry of phosphorylated peptides or sugar chains, which suppresses the desorption of an unstable site during ionization and achieves high sensitivity (i.e., detects molecular-related ions at a high ionic strength and at a relatively higher ionic strength than other ion species derived from the desorption of an unstable site). A method for mass spectrometry of phosphorylated peptides or sugar chains, the method comprising using, as a liquid matrix, an ionic liquid comprising a 3-aminoquinoline ion and a p-coumaric acid ion.
Shimadzu Corporation
03/05/15
20150066421
 Method for following degassing rate by measuring partial pressures measured bymass spectrometry patent thumbnailMethod for following degassing rate by measuring partial pressures measured bymass spectrometry
Where m denotes the set of reference atomic masses, pi denotes the partial pressures for the atomic masses measured by the mass spectrometer, the coefficients αi denote preset weighting coefficients associated with each partial pressure pi, and n denotes a maximum atomic mass for which the partial pressure pi can be measured by the mass spectrometer.. .
03/05/15
20150064739

Analyzer


An analyzer includes a pretreatment device and a mass spectrometer. The pretreatment device includes a solid phase extraction mechanism.
Hitachi High-technologies Corporation
03/05/15
20150060659

Vitamin b2 detection by mass spectrometry


Methods are described for measuring the amount of a vitamin b2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin b2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques..
Quest Diagnostics Investments Inc.
03/05/15
20150060657

Ms/ms analysis using ecd or etd fragmentation


A method of mass spectrometry is disclosed comprising providing a mixture of different analyte ions and supplying electrons or reagent ions to said mixture so as to transfer charge to the analyte ions. The transfer of charge causes at least some of the analyte ions to dissociate and others of the analyte ions not to dissociate, but to form intermediate ions of altered charge state.
Micromass Uk Limited
03/05/15
20150060656

Ion deflection in time-of-flight mass spectrometry


A time-of-flight mass spectrometry (tof ms) system includes an ion deflector, ion extractor, a flight tube, and a detector. The deflector may be disposed in the flight tube or outside the flight tube upstream of the extractor.
Agilent Technologies, Inc.
02/26/15
20150056708

Methods for detecting estrone by mass spectrometry


Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample..
Quest Diagnostics Investments, Inc.
02/26/15
20150053854

Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum


Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry..
Wayne State University
02/26/15
20150053853

Plume collimation for laser ablation electrospray ionization mass spectrometry


In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume.
The George Washington University
02/19/15
20150051283

Composition and inhibition of pkng from mycobacterium tuberculosis


Pkng from mycobacterium tuberculosis is a ser/thr protein kinase that regulates key metabolic processes within the bacterial cell as well as signaling pathways from the infected host cell. This multi-domain protein has a conserved canonical kinase domain with n- and c-terminal flanking regions of unclear functional roles.
Complexa, Inc.
02/19/15
20150051111

Analysis of estradiol and analytes with phenolic oh using labeling chemistry and lc-msms workflow


A method is described for mass spectrometric analysis of a sample comprising phenolic oh, such as a steroid comprising a phenolic oh, using a quaternary amino oxy cookson (qaoc) reagent. The qaoc reagent can improve ionization and fragmentation properties of phenolic oh samples, which can thereby improve quantitation and identification.
Dh Technologies Development Pte. Ltd.
02/12/15
20150045256

Mass spectrometry quantitation of p450 protein isoforms in hepatocytes


A method for screening a drug for cytochrome p450 (cyp) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome p450 isoform. The isoforms can be selected from 2b6, 3a4, 1a2, and 3a5 isoforms.
Dh Technologies Development Pte. Ltd.
02/12/15
20150044713

Method


The present invention provides a method of quantifying the activity of a protein modifying enzyme in a sample, comprising: (i) grouping modified peptides from a first sample and modified peptides from a second sample into a single group according to one of the following parameters: (a) modified peptides having a modification site that is modified by the same protein modifying enzyme; or (b) modified peptides having a modification site that is part of the same modification motif; (ii) calculating enrichment of the modified peptides from the first sample compared to the modified peptides from the second sample in the group; and (iii) calculating the statistical significance of said enrichment; wherein a statistically significant enrichment is indicative of a protein modifying enzyme being activated in the first sample compared to the second sample. In some embodiments, the method further comprises identifying modified peptides in a first sample and a second sample using mass spectrometry (ms) prior to step (i)..
Queen Mary University Of London
02/12/15
20150044708

Methods for detecting oncofetal fibronectin


Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided.
Hologic, Inc.
02/12/15
20150041640

Multi-pole ion trap for mass spectrometry


An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface.
The Rockefeller University
02/12/15
20150041635

Time of flight quantitation using alternative characteristic ions


A method of mass spectrometry is disclosed wherein the intensity of an analyte is determined by determining the intensity of first characteristic fragment ions when the intensity of the first characteristic fragment ions is within a first intensity range corresponding to the detection or unsaturated range of an ion detector. However, when the intensity of the first characteristic fragment ions is outside of the first intensity range so that the ion detector would saturate then the intensity of the analyte is determined by determining the intensity of second different characteristic fragment ions..
Micromass Uk Limited
02/12/15
20150041634

Characterization and prediction of jet fuel quality


Systems and methods are provided for characterizing kerosene fractions in order to determine whether the fractions will satisfy a desired thermal breakpoint specification. Additionally, hydrotreating conditions can be determined that will result in a hydrotreated kerosene fraction that satisfies the desired thermal breakpoint specification.
Exxonmobil Research And Engineering Company
02/05/15
20150037828

Metal organic polymer matrices and systems for chemical and biochemical mass spectrometry and methods of use thereof


Aspects of the disclosure include methods for analyzing an analyte composition by mass spectrometry employing a macroporous metal organic polymer matrix. In practicing methods according to certain embodiments an analyte composition is applied to a macroporous metal organic polymer matrix, a voltage is applied to the macroporous metal organic polymer matrix sufficient to produce and expel analyte ions from the macroporous metal organic polymer matrix and the analyte ions are analyzed by mass spectrometry.
The Board Of Trustees Of The Leland Stanford Junior University
02/05/15
20150034817

Ionization device, mass spectrometry apparatus, mass spectrometry method, and imaging system


A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions.. .
Canon Kabushiki Kaisha
02/05/15
20150034816

Interface for mass spectrometry apparatus


There is provided an interface for use in sampling ions in a mass spectrometer, the interface being arranged for receiving a quantity of ions from an ion source and forming more than one ion beam therefrom, each ion beam being directed along a respective desired pathway.. .
Bruker Chemical Analysis Bv
02/05/15
20150034815

Method for mass spectrometry


A method is provided for mass spectrometry. The method includes generating precursor ions from a sample; transmitting the precursor ions into a collision cell; generating product ions in the collision cell; detecting the precursor and product ions; applying modulation to one or more of the precursor ion intensity and the product ion intensity; and identifying precursor ion and product ion relationships by analyzing intensity profiles defined by the modulation..
Dh Technologies Development Pte. Ltd.
01/29/15
20150032383

Method and system for filtering gas chromatography-mass spectrometry data


This invention relates to a system for and a method of filtering at least a part of gas chromatography-mass spectrometry data, the method comprising: providing gas chromatography-mass spectrometry data (301) for a gas mixture comprising data representing one or more gas chromatography elution peaks obtained for at least one sample, and filtering the gas chromatography-mass spectrometry data (301) to reduce the amount of data, wherein the filtering comprises taking into account predetermined data representing one or more elution peaks previously determined to be false positives (305) and/or predetermined data representing one or elution peaks previously determined to be true positives (304). In this way, unreliable elution peaks are removed in an expedient manner reducing the amount of data e.g.
Koninklijke Philips N.v.
01/29/15
20150031069

Phylogenetic analysis of mass spectrometry or gene array data for the diagnosis of physiological conditions


A universal data-mining platform capable of analyzing mass spectrometry (ms) serum proteomic profiles and/or gene array data to produce biologically meaningful classification; i.e., group together biologically related specimens into clades. This platform utilizes the principles of phylogenetics, such as parsimony, to reveal susceptibility to cancer development (or other physiological or pathophysiological conditions), diagnosis and typing of cancer, identifying stages of cancer, as well as post-treatment evaluation.
01/29/15
20150031063

Method of detecting at least one mechanism of resistance to carbapenems by mass spectrometry


The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a carbapenem, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism..
Biomerieux, Inc.
01/22/15
20150025813

Systems and methods for sequential windowed acquisition across a mass range using an ion trap


Systems and methods are provided to perform sequential windowed acquisition of mass spectrometry data. A mass range and a mass window width parameter are received for a sample.
Dh Technologies Development Pte. Ltd.
01/22/15
20150024510

Performing chemical reactions and/or ionization during gas chromatography-mass spectrometry runs


A gas chromatography-mass spectrometry (gc-ms) method that includes performing a first gc-ms run on a sample using a gas chromatography-mass spectrometry system. Performing the first gc-ms nm includes i) passing a first flow of a carrier gas carrying a first portion of the sample through a gas chromatograph to provide a first effluent; ii) generating first ions under protonation conditions by passing the first effluent through an atmospheric pressure ionization source; iii) passing the first ions through a mass spectrometer; and iv) recording first gc-ms data for the first ions.
Waters Technologies Corporation
01/22/15
20150024428

Method of identification of spore-forming bacillus spp. by direct in-situ analysis of maldi-tof mass spectrometry, and analysis system


A method of the identification of bacillus species by direct in-situ analysis of maldi-tof ms (matrix-assisted laser desorption/ionization time-of-flight mass spectometry) in which spore-forming bacteria are applied intact without any pretreatment, and an analysis system of distinctive biomarkers which allow bacillus spores to be distinguished. Rapid and accurate detection and identification of bacillus species can be achieved by the method and analysis system..
Agency For Defense Development
01/22/15
20150021472

Collision cell for tandem mass spectrometry


A method and apparatus for tandem mass spectrometry is disclosed. Precursor ions are fragmented and the fragments are accumulated in parallel, by converting an incoming stream of ions from an ion source (10) into a time separated sequence of multiple precursor ions which are then assigned to their own particular channel of a multi compartment collision cell (40).
Thermo Fisher Scientific (bremen) Gmbh
01/22/15
20150021471

Electrostatic mass spectrometer with encoded frequent pulses


A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
Leco Corporation
01/22/15
20150021470

Method for imaging mass analysis using physical vapor deposition of platinum nanoparticles


Specifically, the present invention provides a method for imaging mass spectrometry using a sample prepared by physical vapor depositing platinum nanoparticles on the surface of a test sample to be subjected to imaging mass spectrometry.. .
01/15/15
20150017712

Mass spectrometry analysis of microorganisms in samples


The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
Purdue Research Foundation
01/15/15
20150014523

Method for determining the maximum mass peak in mass spectrometry


A fast method for determining molecular mass using mass spectrometry has the following steps: specifying a first adjusting value (m1) of the mass spectrometer, recording the associated signal amplitude (a1), specifying a second adjusting value (m2) which is different to the first, measuring the associated second signal amplitude (a2), specifying a third adjusting value (m3) which is different to the first (m1) and the second (m2) adjusting value, measuring the associated third signal amplitude (a3), determining a quadratic function containing the measured amplitude values as y-values and the specified adjusting values as x-values, determining the maximum of the quadratic function, wherein the searched adjusting value is determined from the x-value of the maximum.. .
Inficon Gmbh
01/08/15
20150008319

Mass spectrometry


A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component.
Micromass Uk Limited
01/08/15
20150008317

System and quantitation in mass spectrometry


A method of operating a tandem mass spectrometer system is disclosed including accumulating ions in an ion trap, transmitting a plurality of ions out of the ion trap into a timed-ion selector, applying a pulsed dc voltage to the timed-ion selector, the pulsed dc voltage being modulated to match an ejection time for selecting a first portion of ions from the plurality of ions, corresponding to a specific m/z window, transmitting the first portion of selected ions out of the timed-ion selector into a reaction cell, transmitting dissociation product ions and the remaining ions of the first portion of selected ions out of the reaction cell into a mass analyzer, and mass-selectively transmitting at least some of the fragment ions and the remaining ions of the first portion of selected ions out of the mass analyzer into a detector.. .
Dh Technologies Development Pte. Ltd.
01/08/15
20150008313

Ionization with femtosecond lasers at elevated pressure


The present disclosure generally provides ionization methods and devices for use in mass spectrometry. In some embodiments, the ionization methods and devices employ short laser pulses (e.g., pulses having pulsewidths in a range of about 2 fs to about 1 ps) at a high intensity (e.g., an intensity in a range of about 1 tw/cm2 to about 1000 tw/cm2) to ionize an analyte an ambient pressure greater than about 10−5 torr (e.g., an ambient pressure in a range of about 1 atmosphere to about 100 atmospheres)..
National Research Council Of Canada
01/08/15
20150008310

Pulsed mass calibration in time-of-flight mass spectrometry


A method is provided for calibrating mass-to-charge ratio measurements obtained from a time-of-flight mass spectrometer used as a detector for a chromatographic system. The method can include introducing a calibrant material into the time-of-flight mass spectrometer after a sample is introduced to the chromatographic system, but before the analysis of the sample is complete, such that calibrant material and sample material are not present at the ion source of the mass spectrometer, contemporaneously, and back-flushing residual or leaking calibrant through a back-flush line and away from the mass spectrometer..
Zoex Corporation
01/01/15
20150004790

Photocured product and producing the same


It is intended to provide a photocured product that is prepared using the photo-imprint method and has favorable pattern precision and improvement in pattern defects. The present invention provides a photocured product obtained by irradiating a coating film in contact with a mold with light, the photocured product containing a fluorine atom-containing surfactant, wherein of secondary ion signals obtained by the surface analysis of the photocured product based on time-of-flight secondary ion mass spectrometry, the intensity of a c2h5o+ ion signal is higher than that of a c3h7o+ ion signal..
Canon Kabushiki Kaisha
01/01/15
20150004644

Method for detecting delta haemolysin of staphylococcus aureus by mass spectrometry directly using a bacterial population


The present invention relates to a method for studying a sample containing a bacterial population of staphylococcus aureus with a specific mass spectrometry technique allowing specific detection on the obtained mass spectrum of the presence or of the absence of a peak at an m/z value of 3005±5 th thomson or at 3035±5 th thomson, and accordingly, to the issuance of a decision conditioned by this result.. .
01/01/15
20150001390

Fast switching, dual polarity, dual output high voltage power supply


Systems, devices, circuits, and methods are provided for an improved mass spectrometry detection system that comprises an ion source and a detector that operate at opposite polarities. In some embodiments, the system can comprise a positive and negative multiplier, each of which can be configured to provide voltage to each of the ion source and the detector.
Dh Technologies Development Pte. Ltd.
01/01/15
20150001387

Dual polarity spark ion source


Devices and techniques for ion analysis, including ion mobility separation and mass spectrometry, are provided using a dual polarity spark ion source and having the flexibility required to optimize the detection performance for a broad range of illicit substances with different physical and chemical properties. In various embodiments, the volatility and electro-chemical aspects may be addressed by the system described herein by performing real-time detection of compounds detectable in both positive and negative polarities and/or prioritizing spectra acquisition in a given polarity due to the high volatility and therefore short residence of certain target compounds..
Implant Sciences Corporation
01/01/15
20150001386

Maldi mass spectrometry of peptides


The present invention provides a mass spectrometry method capable of detecting a smaller amount of peptide. A method for analyzing a peptide by matrix-assisted laser desorption/ionization mass spectrometry, comprising the steps of: dropping, onto a target plate, a peptide solution using, as a solvent, an aqueous solution containing 15 to 50 vol % of acetonitrile, and a matrix solution that uses, as a solvent, an aqueous solution containing 15 to 50 vol % of acetonitrile and that contains 0.05 to 1 mg/ml α-cyano-4-hydroxycinnamic acid, respectively, to prepare a droplet of peptide-matrix mixed solution; removing the solvent from the droplet of peptide-matrix mixed solution to prepare a sample for mass spectrometry as a residue; and irradiating the sample for mass spectrometry with laser to detect the peptide..
Shimadzu Corporation
12/25/14
20140379279

Method of processing spectrometric data


A method of characterising a sample from spectrometric data using calculation of spectral distance values is disclosed, for use in the field of mass spectrometry. Molecular formula assignment of peaks in mass spectral data is difficult and time-consuming, and the invention provides a computer implemented method of finding a most likely elemental composition of a measured spectral peak of interest.
Thermo Fisher Scientific (bremen) Gmbh
12/25/14
20140379277

Quantification of impurities for release testing of peptide products


The present invention relates to a method for the quantitative determination of an impurity present in a peptide product, wherein the impurity cannot be separated from other impurities or the main product. The method particularly involves the use of high resolution mass spectrometry (ms) detection with or without high performance liquid chromatography (hplc).
Sanofi-aventis Deutschland Gmbh
12/25/14
20140374592

Ion extraction ion trap mass spectrometry


A method is provided for processing ions in a multipole ion trap, comprising generating rf radial confinement fields within a first and second multipole rod set positioned in tandem, a ratio of q value exhibited by the second rod set relative to the first rod set being greater than one for any m/z, said rf axial confinement fields within the first and second rod sets interacting in an interaction region between the first and second rod sets so as to produce a fringing field; transmitting ions through said first rod set towards said second rod set; and increasing the radial oscillation amplitude of at least a portion of the ions within said first rod set such that at least a portion of said ions having an increased radial oscillation amplitude are repulsed by said fringing field.. .
Dh Technologies Development Pte. Ltd.
12/25/14
20140374586

Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method


Provided is an ion group irradiation device for facilitating the distinction of peaks in secondary ion mass spectra. The ion group irradiation device for irradiating a sample with an ion group includes an ion source for generating ions, an ion group selecting unit configured to select, from the ions released from the ion source, two or more ion groups formed of ions having different average masses, and a primary ion irradiation unit configured to irradiate the sample with the two or more ion groups.
Canon Kabushiki Kaisha
12/25/14
20140374585

Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method


The present invention provides an ion group irradiation device for irradiating a sample with an ion group, comprising: an ion group selecting unit configured to select, from ions released from an ion source, at least two ion groups formed of ions having different average masses; and a primary ion irradiation unit configured to irradiate the sample with the at least two ion groups selected by the ion group selecting unit, wherein the ion group selecting unit selects at least one ion group and further selects the at least two ion groups from each of the selected at least one ion group.. .
Canon Kabushiki Kaisha
12/25/14
20140374584

Systems and methods for discovery and analysis of markers


A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state.
12/25/14
20140374583

Electron ionization (ei) utilizing different ei energies


mass spectrometry is performed utilizing an electron ionization (ei) source. The ei source ionizes a sample at different electron energies, including below and above 70 ev.
Agilent Technologies, Inc.
12/25/14
20140373649

Use of detection techniques for contaminant and corrosion control in industrial processes


Industrial fluids may be monitored at the site of each industrial fluid by introducing a sample of the industrial fluid into a device employing a detection technique for detecting at least one composition within the sample. The detection technique may be or include surface enhanced raman scattering (sers), mass spectrometry (ms), nuclear magnetic resonance (nmr), ultraviolet light (uv) spectroscopy, uv spectrophotometry, indirect uv spectroscopy, contactless conductivity, laser induced fluorescence, and combinations thereof.
Baker Hughes Incorporated
12/11/14
20140364337

Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards


A method for absolute protein or peptide quantitation by mass spectroscopy. A sample containing a protein or peptide of interest is prepared for mass spectroscopy analysis.
12/11/14
20140364329

Methods for identifying protein-protein interactions


The invention generally relates to methods for identifying protein-protein interactions. In certain aspects, methods of the invention involve conducting a protein-fragment complementation assay on a sample to form a protein-protein complex between two proteins in the sample that only transiently interact under physiological conditions, separating the complexes from the sample, and analyzing a protein of the complex using a mass spectrometry technique..
12/11/14
20140361162

Imaging mass spectrometer and a mass spectrometry


An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process.. .
12/11/14
20140361160

Methods for detecting lacosamide by mass spectrometry


Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample..
12/11/14
20140361156

Methods for simultaneous quantification of thyroid hormones and metabolites thereof by mass spectrometry


The invention provides methods for simultaneously detecting or simultaneously quantifying any combination of thyroxine (t4), triiodothyronine (t3), 3,3′-diiodo-l-thyronine (3,3′-t2), 3-iodothyronamine (t1am), and, optionally, reverse t3 (rt3) in a sample obtained from a human. The method involves a simple, sensitive, accurate, and specific isotope dilution tandem mass spectrometry method for the simultaneous quantification of any combination of t4, t3, 3,3′-t2, t1am, and, optionally, rt3 in a sample obtained from a human, e.g., in human plasma or serum samples.
12/04/14
20140358451

Fractional abundance estimation from electrospray ionization time-of-flight mass spectrum


Methods and systems for detecting and quantifying signal peaks from esi-tof-ms data may include creating a signal model and a noise model for mass spectrometry (ms) data. The method may also include detecting a signal peak based, at least in part, on the signal model and the noise model for the ms data.
12/04/14
20140358449

Method for identifying microorganisms by mass spectrometry


A method of identifying a microorganism by mass spectrometry, including acquiring at least one mass spectrum of said microorganism; for each acquired mass spectrum: detecting peaks of the spectrum in a predetermined mass range; generating a list of peaks identifying at most one peak in each interval of a predetermined subdivision of the range of mass-to-charge ratios, the width of the intervals of the subdivision logarithmically increasing along with the mass-to-charge ratio, and analyzing the list(s) of peaks obtained according to a knowledge base of previously-identified microorganisms and/or types of microorganisms.. .


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Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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