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Mass Spectrometry patents



      

This page is updated frequently with new Mass Spectrometry-related patent applications.




Date/App# patent app List of recent Mass Spectrometry-related patents
05/19/16
20160141168 
 Miniature charged particle trap with elongated trapping region for mass spectrometry patent thumbnailMiniature charged particle trap with elongated trapping region for mass spectrometry
A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles..
The University Of North Carolina At Chapel Hill


05/19/16
20160141165 
 System and  detection and quantification by mass spectrometry and by activating ionised molecular species patent thumbnailSystem and detection and quantification by mass spectrometry and by activating ionised molecular species
Disclosed is a system and method of mass spectrometry, including: a. Ionising an analyte to form a precursor ion (a) having a mass-to-charge ratio (m/z), in which m represents the mass and z the electric charge number; b.
Institut National De La Recherche Agronomique - Inra


05/19/16
20160141164 
 Method for time-alignment of chromatography-mass spectrometry data sets patent thumbnailMethod for time-alignment of chromatography-mass spectrometry data sets
A method is disclosed for adjusting the time scale of chromatography-mass spectrometry data sets, wherein a time scale of a first data set is used as a reference time scale and wherein a time scale of at least one second data set is adapted to the reference time scale comprising the. The steps of the method include identifying feature groups in the first data set by evaluating intensities of consecutive points of the first data set; identifying feature groups in the second data set by evaluating intensities of consecutive points of the second data set; matching feature groups of the first data set to feature groups of the second data set, and determining a corrected time scale for the second data set based on time differences between feature groups in the first data set and matching feature groups in the second data set..
Thermo Fisher Scientific (bremen) Gmbh


05/19/16
20160141162 
 Projection-type charged particle optical system and imaging mass spectrometry apparatus patent thumbnailProjection-type charged particle optical system and imaging mass spectrometry apparatus
Provided is a projection-type charged particle optical system in which a projection magnification can be changed while a decrease in the accuracy in measuring a mass-to-charge ratio is being suppressed. A projection-type charged particle optical system according to the present invention includes a first electrode disposed so as to face a sample and having an opening formed therein for allowing a charged particle to pass, a second electrode disposed on a side of the first electrode opposite to where the sample is disposed and having an opening formed therein for allowing the charged particle to pass, and a flight-tube electrode disposed such that the charged particle that has been emitted from the sample and has passed through the second electrode enters the flight-tube electrode and being configured to form a substantially equipotential space thereinside.
Canon Kabushiki Kaisha


05/19/16
20160139157 
 Methods for detecting vitamin d metabolites by mass spectrometry patent thumbnailMethods for detecting vitamin d metabolites by mass spectrometry
Provided are methods of detecting the presence or amount of a vitamin d metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin d metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin d metabolite in the sample.
Quest Diagnostics Investments Incorporated


05/19/16
20160139143 
 Detecting targets using mass tags and mass spectrometry patent thumbnailDetecting targets using mass tags and mass spectrometry
Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses.
Ventana Medical Systems, Inc.


05/19/16
20160139140 
 Mass labels patent thumbnailMass labels
The present invention provides set of two or more mass labels, wherein each mass label in the set has the same integer mass as every other label in the set, and each mass label in the set has an exact mass which is different to the mass of all other mass labels in the set such that all the mass labels in the set are distinguishable from each other by mass spectrometry.. .
Electrophoretics Limited


05/19/16
20160139134 
 Method for analysis of compounds with amino group and analytical reagent therefor patent thumbnailMethod for analysis of compounds with amino group and analytical reagent therefor
The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-n-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity.
Ajinomoto Co., Inc.


05/19/16
20160138068 
 Method of detection of gram-negative bacteria periplasmic space and cell wall outer membrane proteins by mass spectrometry patent thumbnailMethod of detection of gram-negative bacteria periplasmic space and cell wall outer membrane proteins by mass spectrometry
The invention relates to a method of detection of gram-negative bacteria periplasmic space and cell wall outer membrane proteins by mass spectrometry, wherein the periplasmic space and cell wall outer membrane proteins are extracted from the bacteria, and the proteins to be detected are stabilized by an inhibitor and/or a substrate of the given protein, the proteins are then dissolved, placed onto a maldi-tof plate, covered with matrix solution, measured by maldi-tof mass spectrometry, and the resulting spectra are compared to the reference peaks of the given protein. Preferably, the proteins are beta-lactamases and their detection can be used to quickly determine the bacterial resistance against beta-lactam antibiotics, minimizing the false-positive results..
Univerzita Karlova V Praze, Lekarska Fakulta V Plzni


05/12/16
20160135277 
 Reduction of ambient gas entrainment and ion current noise in plasma based spectrometry patent thumbnailReduction of ambient gas entrainment and ion current noise in plasma based spectrometry
In a plasma source configured for producing sample atoms for analysis, such as by optical emission spectrometry or mass spectrometry, a plasma torch includes a torch exit in a chamber. A baffle is positioned between the torch exit and an opposing boundary.
Agilent Technologies, Inc.


05/12/16
20160133450 

Intelligent dynamic range enhancement


A method of mass spectrometry is disclosed comprising transmitting ions and obtaining first mass spectral data and automatically determining during an acquisition whether the first mass spectral data suffers from saturation or is approaching saturation. If a determination is made during an acquisition that the first mass spectral data suffers from saturation or is approaching saturation then the method further comprises automatically changing or altering the intensity of ions which are detected by an ion detector and obtaining second mass spectral data.
Micromass Uk Limited


05/12/16
20160131665 

Srm/mrm assay for the insulin receptor protein


Specific peptides, and derived ionization characteristics of the peptides, from the insulin receptor protein (ir), and its isoforms ir-a and ir-b, that are particularly advantageous for quantifying the ir protein, ir-a isoform and/or ir-b isoform, directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


05/12/16
20160131620 

Enhanced sensitivity of detection in electrospray ionization mass spectrometry using a post-column modifier and a microfluidic device


A microfluidic liquid chromatography-electrospray ionization (lc-esi) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent.
Waters Technologies Corporation


05/05/16
20160126078 

Integrated mass spectrometry systems


The disclosure features mass spectrometry systems that include: an ion source; a module featuring an ion trap, an ion detector, and a module housing that at least partially surrounds the ion trap and the ion detector; and a vacuum pump featuring a housing having a recess dimensioned to receive the module, so that when the module is positioned within the recess of the vacuum pump housing, a portion of the module is surrounded by the vacuum pump housing, and during operation of the system, the ion source, ion trap, ion detector, and vacuum pump are connected along a common gas flow path and heat is transferred from the vacuum pump to the module.. .
908 Devices Inc.


05/05/16
20160126077 

Method and reacting ions


A method of mass spectrometry is disclosed having a mode comprising: providing a source of precursor ions and reagent ions for reacting with said precursor ions; providing a reaction region downstream of said source; providing an ion mobility separator between said source and said reaction region; providing a bypass cell between said source and said reaction region for guiding ions from said source to said reaction region without the ions passing through said ion mobility separator; guiding said precursor ions from said source, through said ion mobility separator so that said precursor ions separate according to their ion mobility and into said reaction region; and guiding said reagent ions from said source, through said bypass cell and into said reaction region; wherein the reagent ions react with the precursor ions within the reaction region to produce product ions.. .
Micromass Uk Limited


05/05/16
20160126075 

Mass spectrometry measuring vitamin b6 in body fluids


Provided are methods of detecting the presence or amount of the active form of vitamin b6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.. .
Quest Diagnostics Investments Incorporated


05/05/16
20160126073 

Pathology interface system for mass spectrometry


A diagnostic system and method that includes a non-transitory computer readable medium storing machine executable instructions executable by the processor for altering tissue images, the instructions that further includes an input interface configured to receive a plurality of tissue images, the input interface generating enhanced resolution images from the plurality of tissue images for viewing, an annotation interface for positioning coordinates of interest on the enhanced resolution images, and a matrix model configured to evaluate the coordinates of interest on the enhanced resolutions to generate discrete coordinates, the matrix model using the discrete coordinates in performing mass spectrometer analysis to form at least one viewing image. The system also includes a user interface configured to provide at least one viewing image to a user at the display..
Vanderbilt University


05/05/16
20160123936 

Versatile ambient ionization-based interface for lc/ms


An apparatus (10) for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (16), which defines a flow passage (18) and is configured to supply the liquid sample. The fluid conduit (16) has an outer surface and a micro-hole (30) through the outer surface into the flow passage (18).
Ohio University


04/28/16
20160118605 

Light-emitting element, light-emitting device, electronic device, and lighting device


A long-life light-emitting element is provided by reducing a specific kind of impurity in the light-emitting element, particularly an impurity originating in an iridium complex. The light-emitting element includes an iridium complex.
Semiconductor Energy Laboratory Co., Ltd.


04/28/16
20160118236 

Synchronization of ion generation with cycling of a discontinuous atmospheric interface


The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface..
Purdue Research Foundation


04/28/16
20160118234 

Contamination filter for mass spectrometer


Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss..
Dh Technologies Development Pte. Ltd.


04/28/16
20160115436 

Digital microfluidic platform for creating, maintaining and analyzing 3-dimensional cell spheroids


The invention provides a microfluidic system for forming and/or analyzing multi-cellular spheroids in a hanging drop cell culture. Embodiments of the invention include microfluidic (dμf) systems capable of creating and supporting hanging droplets of cell culture media for the purpose of initiating and maintaining the growth of three-dimensional, multi-cellular spheroids.
The Regents Of The University Of California


04/21/16
20160111270 

Glow discharge mass spectrometry


A glow discharge mass spectrometry device and method, the device including a glow discharge lamp (1), gas flow-injection elements, the glow discharge lamp being suitable for forming an ablation plasma in the presence of a plasma gas, and a mass spectrometer. The device further includes heating elements (30, 31) suitable for heating a gas flow (38) upstream of a cell (2), the gas flow-injection elements being suitable for injecting into the glow discharge cell a gas flow (38) heated to a temperature t for a duration d, and pumping elements (7, 27) being designed to pump a flow of gaseous species (17, 37) out of the cell for the duration d, so as to decontaminate the surface of the sample (4) and/or the inner walls of the glow discharge cell (2) before an ablation plasma (5) is ignited..

04/21/16
20160109424 

Swath™ data-independent acquisition technology for the detection of host cell protein contaminants in biotherapeutics protein products


Systems and methods are provided for detecting host cell contaminants in a protein biotherapeutic product using sequential windowed acquisition tandem mass spectrometry. Sequential windowed acquisition is performed on a protein biotherapeutic product sample by sequentially stepping a precursor mass window across a mass range, fragmenting transmitted precursor ions of each stepped precursor mass window, and analyzing product ions produced from the fragmented transmitted precursor ions.

04/21/16
20160106818 

Human coagulation factor light chain protein and use of the same


In the invention, the minimum inhibitory concentrations of human coagulation factor light-chain proteins against different gram-negative bacteria are detected with the in vitro antibacterial activity and the inhibiting effect of the human coagulation factor light-chain proteins against different gram-negative bacteria is detected with the in vivo antibacterial activity. It has been shown that human coagulation factor light-chain proteins have an obvious inhibitory effect on the gram-negative bacteria, so as to develop a novel class of medicaments for treating gram-negative bacteria infection.

04/14/16
20160103138 

Methods for analyzing elastic fiber injury markers and diagnosis of diseases associated with elastic fiber injury


The present invention provides, inter alia, methods for measuring the amount of a marker of elastic fiber injury in a sample. The methods include contacting a sample with a compound of formula (1) and carrying out mass spectrometry on the sample containing the compound of formula (1).

04/07/16
20160099139 

Mass microscope apparatus


A mass microscope apparatus includes: a measuring unit including an ionization unit configured to ionize a sample present in an observation region, and a mass spectrometry unit configured to perform mass spectrometry of ions generated by the ionization unit; an object moving device configured to relatively move the observation region as to the sample; and a switching unit configured to switch measurement conditions of the measuring unit depending on whether the mass microscope apparatus is operating in a moving measurement mode where the observation region is moved by the object moving device to sequentially perform measurement by the measuring unit, and a stationary measurement mode where the observation region is stationary and measurement is performed by the measuring unit.. .
Canon Kabushiki Kaisha


04/07/16
20160099137 

Mass spectrometry by detecting positively and negatively charged particles


The disclosure features mass spectrometry systems and methods that include an ion source, an ion trap, a detector subsystem featuring first and second detector elements, and a controller electrically connected to the ion source, the ion trap, and the detector subsystem and configured so that during operation of the system, the controller: applies an electrical signal to the ion source to generate positively and negatively charged particles from sample particles in the system; applies an electrical signal to the ion trap to eject a plurality of particles from the ion trap through a common aperture of the ion trap, and determines information about the sample particles based on first and second electrical signals generated by the ejected particles.. .
908 Devices Inc.


04/07/16
20160099136 

Systems and methods for acquiring data for mass spectrometry images


Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.


04/07/16
20160098514 

Predictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample


A programmed computer functioning as a classifier operates on mass spectral data obtained from a blood-based patient sample to predict indolence or aggressiveness of prostate cancer. Methods of generating the classifier and conducting a test on a blood-based sample from a prostate cancer patient using the classifier are described..
Biodesix, Inc.


04/07/16
20160097749 

Analyte mass spectrometry quantitation using a universal reporter


Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.. .

03/31/16
20160092151 

Mass spectrometry data processing apparatus


A mass spectrometry data processing apparatus having a function of displaying a plurality of msn spectra in an arranged manner is allowed to display these msn spectra in a state where a user can easily grasp presence or absence of a common neutral loss. A mass spectrometry data processing apparatus 20 that displays, on a display screen, an msn spectrum resulting from mass spectrometric analysis of n−1 stage dissociation, where n is integer of two or more, of an ion, includes: a precursor ion identifying section 32 configured to identify, for each of a plurality of msn spectra, a mass-to-charge ratios m/z of a precursor ion from which the msn spectra are obtained; and a spectrum aligning section 33 configure to display the msn spectra on the display screen in a vertically arranged manner such that positions of the mass-to-charge ratios m/z of the respective precursor ions are located at a same horizontal position of the display screen..
Shimadzu Corporation


03/31/16
20160091467 

Prediction of fuel properties


A system is described that includes a known fuels database of data from gas chromatography-mass spectrometry analyses of a library of fuels with known fuel properties for a multiple known fuel samples. Gas chromatography-mass spectrometry equipment can acquire gas chromatography-mass spectrometry data for an unknown fuel sample.
The Government Of The United States Of America, As Represented By The Secretary Of The Navy


03/24/16
20160087049 

Epitaxial silicon wafer


An epitaxial silicon wafer includes: a silicon wafer; and a silicon epitaxial layer formed on the silicon wafer, in which a w concentration obtained by a metal analysis of a surface of the silicon epitaxial layer using an inductively coupled plasma mass spectrometry is 1×106 atoms/cm2 or less. Further, the w concentration obtained by the metal analysis of the surface of the silicon epitaxial layer using the inductively coupled plasma mass spectrometry is preferably 1×107 atoms/cm2 or less..
Sumco Corporation


03/24/16
20160086786 

Isolation of charged particle optics from vacuum chamber deformations


A charged particle processing apparatus includes a vacuum chamber, an optics plate, charged particle optics mounted to the optics plate, and mounting members coupled between the optics plate and a chamber wall. The mounting members are configured for isolating the optics plate from deformation of the chamber wall, as may occur due to a pressure differential between the chamber interior and the environment outside the chamber.
Agilent Technologies, Inc.


03/24/16
20160086785 

Methods and devices for generating double emulsions


The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer.
University Of Washington Through Its Center For Commercialization


03/24/16
20160086783 

Improved data quality after demultiplexing of overlapped acquisition windows


Systems and methods are provided for identifying missing product ions after demultiplexing product ion spectra produced by overlapping precursor ion transmission windows in sequential windowed acquisition tandem mass spectrometry. Overlapping sequential windowed acquisition is performed on a sample.
Dh Technologies Development Pte. Ltd.


03/24/16
20160086782 

Species detection using mass spectrometry


Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (mrm) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer.
Dh Technologies Development Pte. Ltd.


03/24/16
20160086780 

Multi-segment injection-capillary electrophoresis-mass spectrometry (msi-ce-ms): a multiplexed screening platform and data workflow for chemical analysis


Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (ce-ms) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (ce) run.
Mcmaster University


03/17/16
20160079052 

Method and mass spectrometry


A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (mr tof) mass spectrometry..
Thermo Fisher Scientific (bremen) Gmbh


03/17/16
20160079050 

Mass spectrometry method, ion generator and mass spectrometry system


A mass spectrometry method includes a step of atomizing liquid including a sample using an ultrasonic transducer; a step of transferring the atomized liquid; a step of generating ions from the transferred liquid using a dart ion source; and a step of analyzing a mass spectrometry by introducing the generated ions into a mass spectrometer.. .
Bio Chromato, Inc.


03/17/16
20160079049 

Methods for detecting reverse triiodothyronine by mass spectrometry


Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample..
Quest Diagnostics Investments Incorporated


03/17/16
20160079048 

Systems and methods for rapidly screening samples by mass spectrometry


Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079047 

Systems and methods for using variable mass selection window widths in tandem mass spectrometry


Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079046 

Multiple frequency rf amplifier, mass spectrometer including the same, and mass spectrometry mass spectrometer


Provided is a multiple frequency radio frequency (rf) amplifier. The multiple frequency rf amplifier includes a waveform generation circuit configured to generate an rf signal by amplitude and frequency-modulating a reference waveform signal, a drive amplifier circuit configured to drive-amplify the rf signal, and a power amplifier circuit configured to generate a multiple frequency rf voltage signal through a power amplification of the drive-amplified rf signal and output the multiple frequency rf voltage signal to an ion trap for a mass spectrometry..
Korea Basic Science Institute


03/10/16
20160071710 

Mass spectrometry with selective ion filtration by digital thresholding


The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process..
Ibis Biosciences, Inc.


03/10/16
20160069848 

Liquid chromatograph mass spectrometer


In a liquid chromatograph mass spectrometer (lc/ms) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional lc or similar lc with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the lc depending on the kind of column or other factors or the degree of ease of ionization in the ms. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information.
Shimadzu Corporation


03/03/16
20160061848 

Mass spectrometry of steroidal compounds in multiplexed patient samples


The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry..
Quest Diagnostics Investments Incorporated


03/03/16
20160061790 

Quantification of asphaltene inhibitors in crude oil using thermal analysis coupled with mass spectrometry


The present invention generally relates to a novel method for the characterization and quantification of involatile macromolecules in hydrocarbon samples of crude oil. More particularly, the method utilizes pyrolysis/gas chromatography/mass spectrometry (py/gc/ms, py/gc/ms/ms or py/gc/triple quad ms) to detect and quantify polymeric asphaltene inhibitors in crude oil..
Ecolab Usa Inc.


03/03/16
20160060688 

Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest


This invention pertains to identifying one or more hybridization probes sequestered within (or optionally released from the intact) cells or microorganisms by mass spectrometry to thereby determine a trait of the cells or microorganisms and/or to identify the cells or microorganisms themselves. The cells or microorganisms can come from a subject and the information obtained from the mass spectrometry analysis may, if clinically relevant, optionally be used to diagnose and/or treat the subject..
Advandx, Inc.


02/25/16
20160056031 

Sample analysis for mass cytometry


The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (la-icp-ms). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the icp, followed by analysis by mass cytometry..
Fluidigm Canada Inc.


02/25/16
20160056030 

System and delicate membrane condensed phase membrane introduction mass spectrometry (cp-mims)


Systems and methods for analyzing a sample comprising an analyte selected from a volatile organic compound, a semi-volatile organic compound, a non-volatile organic compound, a polar organic compound and a halogenated non-volatile organic compound are provided. The systems comprises an ionization source, a flow cell or an immersion probe with a delicate membrane, the flow cell or immersion probe for accepting the sample, and the delicate membrane interface in fluid communication with the ionization source and a mass spectrometer.

02/25/16
20160056028 

Ultraclean autosampler with syringe delivery for mass spectrometry


A system can include a valve assembly including a first valve and a second valve in fluid communication with the first valve. The valve assembly can be configured to deliver one or more of a sample, a chemical (e.g., an acid, a base, an organic chemical, etc.), and a standard via flow of a working fluid facilitated by one or more syringe pumps.
Elemental Scientific, Inc.


02/25/16
20160056027 

Quantitative analysis method using mass spectrometry wherein laser pulse energy is adjusted


A quantitative analysis method using maldi mass spectrometry wherein laser pulse energy is adjusted is disclosed. More particularly, a method for measuring the equilibrium constant of a proton exchange reaction between a matrix and a sample at a constant temperature, by dividing an ion signal ratio by a value (concentration ratio) obtained by dividing the concentration of the sample by the concentration of the matrix, may include (i) obtaining maldi mass spectra having constant tics by adjusting the intensity of energy applied to a specimen having a predetermined amount of a matrix and a predetermined amount of a sample mixed therein and (ii) measuring the maldi mass spectra obtained in step (i) for a value (ion signal ratio) obtained by dividing sample ion signal strength by matrix ion signal strength..
Snu R &db Foundation


02/25/16
20160054332 

Mass spectrometric determination of drug resistance


The invention relates to a method to determine drug resistance in microbes. The method relates to measuring the drug resistance conferring protein by mass spectrometry.
Erasmus University Medical Center Rotterdam


02/25/16
20160054323 

Srm/mrm assay for subtyping lung histology


The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins that are particularly advantageous for quantifying the krt5, krt7, napsina, ttf1, tp63, and/or muc1 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


02/25/16
20160053297 

Thyroglobulin quantitation by mass spectroscopy


Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample..
Quest Diagnostics Investments Incorporated


02/18/16
20160049287 

Ion trap array


The invention “ion trap array (ita)” pertains generally to the field of ion storage and analysis technologies, and particularly to the ion storing apparatus and mass spectrometry instruments which separate ions by its character such as mass-to-charge ratio. The aim of this invention is providing an apparatus for ion storage and analysis comprising at least two or more rows of parallel placed electrode array wherein each electrode array includes at least two or more parallel bar-shaped electrodes, by applying different phase of alternating current voltages on different bar electrodes to create alternating electric fields inside the space between two parallel electrodes of different rows of electrode arrays, multiple linear ion trapping fields paralleled constructed in the space between the different rows of electrode arrays which are open to adjacent each other without a real barrier.
Fudan University


02/18/16
20160049283 

Laser ablation cell


A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel.
Paul Scherrer Institut


02/18/16
20160047831 

Mass spectral analysis


The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis..
Purdue Research Foundation


02/18/16
20160047782 

Mass spectrometry (ms) identification algorithm


A system includes a gas chromatograph configured to determine experimental chromatographic data including retention times associated with samples. The system also includes a mass spectrometer configured to determine experimental mass spectral data associated with samples.
Smiths Detection Inc.


02/11/16
20160042936 

Compact mass spectrometer


Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.


02/11/16
20160042930 

Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


02/11/16
20160041183 

Thyroglobulin quantitation by mass spectrometry


Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample..
Quest Diagnostics Investments Incorporated


02/04/16
20160035552 

Method and system for tandem mass spectrometry


A method of data independent ms-ms analysis is disclosed. The method comprises ramping or stepping in small steps of a wide (at least 10 amu) parent mass window in a first parent selecting mass spectrometer (ms1), arranging rapid ion transfer through a collisional cell, either by axial gas flow or by an axial dc field or by a travelling rf wave, frequently pulsing an orthogonal accelerator with a string of time-encoded pulses, analyzing fragment ions in a multi-reflecting time-flight mass spectrometer, acquiring data in a data logging format, and decoding signal strings corresponding to the entire scan of parent masses, such that fragment spectra are formed based on time correlation between fragment and parent masses.
Leco Corporation


02/04/16
20160035551 

Data dependent control of the intensity of ions separated in multiple dimensions


A method of mass spectrometry is disclosed comprising setting an attenuation factor of an attenuation device to a first value and then separating or filtering ions according to a first physico-chemical property and separating or filtering ions according to a second physico-chemical property and obtaining a multi-dimensional array of data. The most intense ion peak within one or more subsets of the multi-dimensional array of data is determined.
Micromass Uk Limited


02/04/16
20160035550 

Plasma cleaning for mass spectrometers


A mass spectrometry (ms) system may be cleaned by generating plasma and contacting an internal surface of the system to be cleaned with the plasma. The system may be switched between operating in an analytical mode and in a cleaning mode.
Agilent Technologies, Inc.


02/04/16
20160033527 

System and determining amino acid sequence of polypeptide


This invention discloses systems and methods for determining the sequence of amino acids in a short peptide chain that constructs a protein. The protein is firstly hydrolyzed to various short peptides and amino acid enantiomers.
Chung Yuan Christian University


02/04/16
20160033522 

Methylcitrate analysis in dried blood spots


There is provided a method of measuring methylcitrate (mca) in a sample by derivatizing the mca, for example with 4-[2-(n,n-dimethylamino)ethylaminosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole (daabd-ae); measuring a level of the derivatized mca; and determining the level of mca from the measured level. The sample may be a dried blood spot (dbs), and the extraction and derivatization may be carried out simultaneously.
Children's Hospital Of Eastern Ontario


02/04/16
20160032273 

Characterization of mrna molecules


The present invention describes methods for the characterization of mrna molecules during mrna production. Characterizing mrna includes processes such as oligonucleotide mapping, reverse transcriptase sequencing, charge distribution analysis, and detection of rna impurities.
Moderna Therapeutics, Inc.


02/04/16
20160031047 

Method and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system


A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (cg-ms) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the gc-ms system, at a location between a high vacuum end of a transfer line and a mass analyzer of the gc-ms system.
Thermo Finnigan Llc


02/04/16
20160030369 

Fkbp52 targeting agent pharmaceutical compositions


Liposomes comprising an fkbp52 targeting agent (fta) are disclosed. Pharmaceutical compositions comprising an fta, a solvent, and a surfactant are disclosed.
The Board Of Regents Of The University Of Texas System


01/28/16
20160027631 

Measurement device, measurement apparatus, and method


A metal film of a measurement device including a transparent dielectric substrate is irradiated with first light from a transparent dielectric substrate side, an optical electric field enhanced by an optical electric field enhancing effect of a localized plasmon induced to a surface of the metal film by the irradiation is generated, light emitted from the transparent dielectric substrate side is detected, a specimen installed on a surface of a metal fine concavo-convex structure layer and a matrix agent are irradiated with second light from a side opposite to the side of the irradiation with the first light in a state where a voltage is applied to the metal fine concavo-convex structure layer through a voltage application electrode, an analysis target substance for mass spectrometry in the specimen is desorbed from the surface by the irradiation, and the desorbed analysis target substance is detected.. .
Fujifilm Corporation


01/28/16
20160027629 

Apparatus for elemental analysis of particles by mass spectrometry


A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
Fluidigm Canada Inc.


01/28/16
20160027628 

Improved data dependent control


A method of mass spectrometry is disclosed comprising obtaining first data at a first time and/or location and second data at a second subsequent time and/or location. A future trend or rate of change in the data is predicted from the first and second data.
Micromass Uk Limited


01/28/16
20160025742 

Synthesis and use of isotopically-labelled glycans


Isotopically-labelled glycans and their synthesis and use as internal standards in the analysis by mass spectrometry of glycan mixtures is described. The methods of synthesis described herein may be used conveniently to prepare libraries of heavy glycans for use in the qualitative and quantitative identification of glycans in natural samples..
AsociaciÓn Centro De InvestigaciÓ Cooperativa En Biomateriales


01/28/16
20160025741 

System and the detection of allergens


Methods and systems for detecting allergens using mass spectrometry are provided herein. In some aspects, a sample can be screened for the presence or quantity of ovalbumin, lysozyme, casein (isoform s1 and s2), lactoglobulin, high and low glutens, wheat, rye, oats, barley, mustard, sesame, and various types of nuts including macadamia, pistachio, brazil, walnuts, peanuts and hazelnuts by detecting one or more peptides specific to the allergen of interest using selected mrm transitions..
Dh Technologies Development Pte. Ltd.


01/28/16
20160025692 

Analysis system


An analysis system is provided with: a storage unit that stores first information associating mass spectrometry result information with an analysis condition concerning ion mobility separation; and a control unit that determines, as a first analysis condition for an ion to be measured, the analysis condition associated with the mass spectrometry result information of the first information corresponding to the mass spectrometry result information of the ion to be measured.. .
Hitachi High- Technologies Corporation


01/28/16
20160025691 

Chromatography/mass spectrometry data processing device


Using the intensity ratio of peaks on a standard mass spectrum of the target compound and peaks with the same m/z on the measured mass spectrum near the retention time of said compound, a scale factor waveform close to the chromatogram shape based on the target compound alone is computed, and m/z candidates for quantitation are extracted based on the correlation between the measured mass chromatogram of the target compound and the scale factor waveform. Furthermore, an intensity ratio is determined with reference to the m/z peaks showing the greatest scale factor on the measured mass spectrum at the measurement time point showing the greatest scale factor in the scale factor waveform, and m/z candidates for quantitation/confirmation are narrowed down based on whether they fall within an allowable range based on peak intensity ratio on the standard mass spectrum..
Shimadzu Corporation


01/28/16
20160025603 

Airborne agent collectors, methods, systems and devices for monitoring airborne agents


Air flow systems, devices and methods for monitoring airborne agents include airborne agent collectors. Airborne agent collectors for collecting and detecting the presence and/or identification of an airborne agent(s) include a soluble and hydrophilic polycaprolactone (pcl) that has been treated with a base (e.g., a base having a ph greater than 8 (e.g., naoh, nahco3, koh, na2co3, and ca(oh)2) and in some embodiments, also treated with a neutralizing agent for increasing hydrophilicity.
Diomics Corporation


01/28/16
20160024492 

Removal of dna fragments in mrna production process


The present invention describes methods of removing dna from an rna transcript during the mrna production process. The method embodies procedures for obtaining an in vitro transcription product, and removing any dna from the product.
Moderna Therapeutics, Inc.


01/21/16
20160020083 

Adjusting precursor ion populations in mass spectrometry using dynamic isolation waveforms


A mass spectrometry technique for isolating a plurality of isolated ions from a plurality of injected ions using a dynamic isolation waveform to create at least one isolation notch. Isolating the plurality of isolated ions may include collecting at least a first target ion, but not a second target ion, using the at least one isolation notch for a first period of time; changing at least one property of the at least one isolation notch; and collecting at least the first target ion and the second target ion using the at least one isolation notch for a second period of time..
President And Fellows Of Harvard College


01/21/16
20160020082 

Mass spectrometer system and method


An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage u, an amplitude v of a radio-frequency voltage, and a frequency f of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger.
Hitachi High-technologies Corporation


01/21/16
20160020080 

Sample plate for maldi-tof mass spectrometer and manufacturing the sample plate and mass spectrometry method using the sample plate


The present invention relates to a sample plate to be used for a maldi-tof (matrix assisted laser desorption ionization time of flight) mass spectrometer, and more particularly, to a sample plate for a maldi-tof mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a maldi-tof mass spectrometer so as to overcome the limits of the gas chromatography method of the related art.
Industry-academic Cooperation Foundation, Yonsei University


01/21/16
20160020076 

Collision cell for tandem mass spectrometry


A method and apparatus for tandem mass spectrometry is disclosed. Precursor ions are fragmented and the fragments are accumulated in parallel, by converting an incoming stream of ions from an ion source (10) into a time separated sequence of multiple precursor ions which are then assigned to their own particular channel of a multi compartment collision cell (40).
Thermo Fisher Scientific (bremen) Gmbh


01/21/16
20160018410 

Deep maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof


A method of analyzing a biological sample, for example serum or other blood-based samples, using a maldi-tof mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a maldi-tof sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument.
Biodesix, Inc.


01/21/16
20160018368 

Mass spectrometry s


Proposed schematic ion optical diagrams allow to developing different ms types.. .

01/21/16
20160018361 

System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry


An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges.



Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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