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 Ruggedized advanced identification mass spectrometer patent thumbnailnew patent Ruggedized advanced identification mass spectrometer
A dual-ionization mass spectrometer includes a first mass spectrometer module forming a hard ionization mass spectrometer, a second mass spectrometer forming a soft ionization mass spectrometer, a vacuum ultraviolet light source positioned between the first and second modules, a housing encompassing the first and second sets of plates and the light source, and an inlet positioned to receive a sample of an analyte and provide it to at least one of the sets of plates. A method of detecting a substance includes receiving a sample of an analyte into a housing through an inlet, performing soft ionization mass spectrometry on the sample with a soft ionization mass spectrometer in the housing, performing hard ionization spectrometry on the sample with a hard ionization spectrometer in the housing if needed, and generating a detection result from at least one of the soft ionization spectrometry and the hard ionization spectrometry..
Sri International


 Amino acid sequence analyzing method and system patent thumbnailnew patent Amino acid sequence analyzing method and system
Peptide-fragment mixtures obtained by fragmenting a sample with each of multiple enzymes which cause cleavage at different sites are subjected to mass spectrometry. De novo sequencing is performed on the obtained results to deduce partial sequence candidates for various kinds of fragments (s1 and s2).
Shimadzu Corporation


 Multiplex mrm assay for evaluation of cancer patent thumbnailnew patent Multiplex mrm assay for evaluation of cancer
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (er), progesterone receptor (pr), and/or antigen ki67 (ki67) proteins that are particularly advantageous for quantifying the er, pr, and/or ki67 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


 Method of isolating ions patent thumbnailnew patent Method of isolating ions
A method of mass spectrometry is disclosed comprising isolating a group of different ions derived from chemical compounds in the same class, wherein the different ions have different mass to charge ratios and ion mobilities. The step of isolating comprises temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter.
Micromass Uk Limited


 Method of associating precursor and product ions patent thumbnailnew patent Method of associating precursor and product ions
A method of mass spectrometry is disclosed comprising selecting a modification of interest that may modify the mass to charge ratios of precursor ions of interest when said precursor ions are subjected to a fragmentation or reaction condition for producing product ions. The method then filters the product ions (or product ion data) such that only a subset of the product ions are transmitted and detected (or a subset of the data remains) and so as to exclude product ions (or product ion data) that could not have possibly resulted from the modification of interest.
Micromass Uk Limited


 Fuel markers and methods of producing and using same patent thumbnailnew patent Fuel markers and methods of producing and using same
Wherein x can be carbon (c), oxygen (o), or sulfur (s); r1 and r2 can each independently be hydrogen, a c1 to c20 alkyl group, or a c6 to c10 aryl group; r3 and r3′ can each independently be hydrogen or a c1 to c4 alkyl group; r4 and r4′ can each independently be hydrogen, a c1 to c4 alkyl group, a c4 to c10 cycloalkyl group, or a c6 to c10 aryl group; r5 and r5′ can each independently be a c4 to c10 alkyl group; r6 and r6′ can each independently be hydrogen or a c1 to c6 alkyl group; and r7 and r7′ can each independently be hydrogen or a c1 to c4 alkyl group; and wherein the compound characterized by formula i when subjected to gas chromatography-mass spectrometry (gc-ms) using electron ionization produces at least one ion having a mass-to-charge ratio of greater than about 300 at an ionization energy of equal to or greater than about 70 ev.. .

 Microscale mass spectrometry systems, devices and related methods patent thumbnailMicroscale mass spectrometry systems, devices and related methods
mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly.
The University Of North Carolina At Chapel Hill


 Ion trap mass spectrometers patent thumbnailIon trap mass spectrometers
A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region; selecting a target maximum charge desired to be stored within the ion storage region at any given time; and reducing the ion current passing to the ion storage region such that the ions entering the ion storage region do not cause the total charge within the storage region to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region comprises: temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter.
Micromass Uk Limited


 Charge-stripping of multiply-charged ions patent thumbnailCharge-stripping of multiply-charged ions
A method of mass spectrometry or ion mobility spectrometry is disclosed wherein a sample is ionised by an electrified sprayer so as to produce multiply charged analyte ions of a first polarity in gas-phase. A reaction region is provided downstream of the electrified sprayer, wherein the reaction region is maintained substantially at atmospheric pressure and is maintained substantially free of electric-fields.
The University Of British Columbia


 Methods for data-dependent mass spectrometry of mixed biomolecular analytes patent thumbnailMethods for data-dependent mass spectrometry of mixed biomolecular analytes
A method for mass spectral analysis of a sample containing a plurality of biomolecule species comprises: (a) mass analyzing a plurality of first-generation ion species generated from a sample portion; (b) automatically recognizing, for each of at least one biomolecule species, a respective subset of m/z ratios corresponding to respective first-generation ion species generated from the each biomolecule species; (c) selecting, from each recognized subset, a single representative m/z ratio; (d) isolating a sub-population of ions having each representative m/z ratio from ions having other m/z ratios; and (e) fragmenting each isolated sub-population of ions so as to generate second-generation ion species.. .
Thermo Finnigan Llc


Mass spectrometry-based identifying and maintaining quality control factors during the development and manufacture of a biologic


The invention provides methods for determining a set of critical features that serves as a “map” of attributes critical for maintaining the structure and function of a biologic. The map can serve as a development tool, e.g., as a guide or target during the development of expression, purification, and formulation protocols, a quality assurance tool during manufacturing, or as a definitive identifier of the specific biologic.
Bioanalytix, Inc.


Template for epitaxial growth, producing the same, and nitride semiconductor device


The present invention provides a method for producing a template for epitaxial growth, the method including: a surface treatment step of dispersing ga atoms on a surface of a sapphire substrate; and an aln growth step of epitaxially growing an aln layer on the sapphire substrate, wherein in a ga concentration distribution in a depth direction perpendicular to the surface of the sapphire substrate in an internal region of the aln layer excluding a near-surface region up to a depth of 100 nm from the surface of the aln layer, which is obtained by secondary ion mass spectrometry, a position in the depth direction where the ga concentration takes the maximum value is present in a near-interface region located between the interface of the sapphire substrate and a position at 400 nm spaced apart from the interface to the aln layer side, and the maximum value of the ga concentration is 3×1017 atoms/cm3 or more and 2×1020 atoms/cm3 or less.. .
Soko Kagaku Co., Ltd.


Laser enabled imaging mass cytometry


The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (la-icp-ms). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the icp, followed by analysis by mass cytometry..
Fluidigm Canada Inc.


Electrically conductive and filtrating substrates for mass spectrometry


A mass spectrometry substrate includes an electrically conductive material providing an electrical conductivity that allows at least one of a first and a second surface of the substrate to be maintained at a desirable potential for ion extraction while ions are desorbed during ionization. A solid lattice material comprises a plurality of pores positioned in a plurality of layers that form a network of at least one continuous channel extending from a first surface of the substrate to a second surface of the substrate.
Virgin Instruments Corporation


Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers


mass spectrometry cells include one or more interleaved magnetostatic and electrostatic lenses. In some examples, the electrostatic lenses are based on electrical potentials applied to magnetostatic lens pole pieces.
Oregon State University


Methods and systems for measuring serotonin in a sample


Disclosed are methods and systems for measuring serotonin in a sample using liquid chromatography and mass spectrometry.. .
Laboratory Corporation Of America Holdings


Compounds and methods for peg metabolite and peg breakdown product assays


Disclosed herein are compounds and methods for identifying and quantifying a metabolite or breakdown product of peg. A sample may be assayed for peg metabolites or breakdown products using liquid chromatography combined with mass spectrometry.
Colonaryconcepts Llc


Mass spectrometry analysis of microorganisms in samples


The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
Purdue Research Foundation


Ms/ms analysis using ecd or etd fragmentation


A method of mass spectrometry is disclosed comprising: providing supercharged analyte ions; and supplying electrons or reagent ions to said analyte ions so as to transfer charge from said reagent ions or electrons to said analyte ions, said transfer of charge causing at least some of said analyte ions to dissociate. The charge transfer step is performed at a relatively high pressure and preferably substantially at atmospheric pressure..
Micromass Uk Limited


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Data dependent ms/ms analysis


A method of mass spectrometry is disclosed comprising comparing mass spectral data so as to identify a precursor ion in the mass spectral data that has a predetermined mass difference to a product ion in the mass spectral data; and determining whether said precursor ion is a precursor ion of interest by comparing the ion signal profile for the precursor ion with the ion signal profile for the product ion. If the profiles match then the precursor ion is determined to be an ion of interest.
Micromass Uk Limited


Cmet protein srm/mrm assay


Specific peptides are provided, and derived ionization characteristics of those peptides, from the hepatocyte growth factor receptor (cmet) protein. The peptides are particularly and surprisingly advantageous for quantifying by the method of selected reaction monitoring (srm) mass spectrometry the cmet protein directly in biological samples that have been fixed in formalin, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry.
Expression Pathology, Inc.


Quaternary amine containing isobaric tag for quantitative glycan profiling


The disclosure provides quaternary amine containing isobaric tag reagents useful in the analysis of biomolecules and methods of making and using the quaternary amine containing isobaric tag reagents. The quaternary amine containing isobaric tag reagents are particularly useful for glycan analysis, especially quantitative glycan profiling such as glycan quantitation by tandem mass spectrometry..
University Of Maryland, College Park


System and high throughput mass spectrometric analysis of proteome samples


Disclosed herein is a system and method for analyzing a specimen containing the proteome by mass spectrometry. The system includes a protein separation module; a matrix processing module; and a mass spectrometer module.
Northwestern University


Enzyme coupled assay for quantification of protein and peptide binding by samdi mass spectrometry


Disclosed herein are methods of using an immobilized substrate, immobilized ligand, and a fusion protein of an enzyme for the substrate and a receptor for the ligand, where the immobilized substrate can react to form an immobilized product that has a different mass than the immobilized substrate, and using this transformation to indirectly determine the binding of the receptor and the ligand. These methods can be used for high-throughput screening for possible modulators (e.g., inhibitors or activators) of the ligand-receptor interaction..
Northwestern University


Mass spectrometry-cleavable cross-linking agents to facilitate structural analysis of proteins and protein complexes, and using same


Where x is an n-hydroxy-succinimidyl or similar heterocyclic group. Also provided is a method of mapping protein-protein interactions of protein complexes using various mass spectrometry techniques..

Dynamic resolution correction of quadrupole mass analyser


A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition.. .
Micromass Uk Limited


Microbial analysis


The present invention is concerned with a method of identifying microbial strains (e.g. From a cell culture), the method comprising; i) a lipid extraction step, comprising extraction of phospholipids from the microbe, suitably with an extraction composition comprising more than 50 vol % meoh; ii) a sample preparation step, comprising preparation of a maldi sample incorporating the extracted lipids; iii) a data gathering step, comprising performing maldi-based mass spectrometry on the maldi sample, and iv) a microbe identification step, comprising analysis of the mass spectrometry data to characterise or identify the microbial strain.
Kratos Analytical Limited


Mass spectrometers comprising accelerator devices


A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
Micromass Uk Limited


Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


Multidrug analysis in urine by liquid chromatography-tandem mass spectrometry


A fast and reliable method for the determination of multiple drugs and their metabolites belonging to different chemical and toxicological class from a biological sample is provided. The method involves mixing of biological sample with internal standards which does not require sample extraction or derivatization prior to analysis.
Castle Medical, Llc


Use of windowed mass spectrometry data for retention time determination or confirmation


A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans.
Dh Technologies Development Pte. Ltd.


Time-of-flight mass spectrometry using multi-channel detectors


A time-of-flight mass spectrometer (tof-ms) utilizes a multi-channel ion detector to detect ions traveling in separate flight paths, spatially dispersed along a drift axis and/or a transverse axis, in a flight tube of a tof analyzer. The ion beams may be dispersed by drift energy, deflection along the drift and/or transverse axis, ion mass, or a combination of two or more of the foregoing.
Agilent Technologies,inc.


Mass spectrometry data processing apparatus and mass spectrometry data processing method


A mass spectrometry data processing apparatus includes a data analysis unit that processes a mass spectrum of each of analysis-target areas within a two-dimensional range set on a sample. The data analysis unit obtains a plurality of mass spectra each associated with position information of a corresponding one of the analysis-target areas; creates an average mass spectrum that is an average of the plurality of obtained mass spectra; extracts, for each mass range, a highest peak by comparing the plurality of obtained mass spectra with one another, and creates a maximum mass spectrum constituted by the extracted highest peaks; creates an intensity ratio spectrum indicating an intensity ratio of the average mass spectrum to the maximum mass spectrum; and selects a peak in a range of a threshold set for the intensity ratio spectrum and specifies a mass range including the peak..
Jeol Ltd.


Methods and compositions for enzyme linked immuno and hybridization mass spectrometric assay


Disclosed are sensitive methods for detecting a target substance in low concentrations. The method can include immobilizing a target substance to a solid phase; incubating the immobilized target substance with a reporter enzyme detection probe in solution under conditions for forming target: enzyme detection probe complexes; washing the solid phase to remove any unbound reporter enzyme detection probe; incubating the target: enzyme detection probe complex with a reporter enzyme detection probe substrate in substrate reaction solution to generate one or more ionizable products; and detecting one or more of the one or more ionizable products using mass spectrometry (ms)..
Yyz Pharmatech, Inc.


Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugate


Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, and purifications.
Bio-rad Laboratories, Inc.


Time-of-flight mass spectrometer


An embodiment of the invention relates to a tof-ms capable of performing mass spectrometry of a sample at a high throughput. The tof-ms has an acceleration part for accelerating an ion, a detector for detecting an event of arrival of the accelerated ion, and a data processing part for performing mass spectrometry of the sample, based on a time of flight of the ion.
Hamamatsu Photonics K.k.


Multiplexed precursor isolation for mass spectrometry


Systems and methods for multiplexed precursor ion selection are provided. A mass isolator includes a selection region of rods, a transmission region of rods, and a barrier electrode lens separating the selection and transmission regions.
Dh Technologies Development Pte. Ltd.


Multiplexed precursor isolation for mass spectrometry


Systems and methods for identifying precursor ions of product ions from combined product ion spectra are provided. N precursor ions are selected.
Dh Technologies Development Pte. Ltd.


Srm/mrm assay for the fatty acid synthase protein


Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


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Methods for identifying fungi


Methods for identifying fungal species by analysis of fungal membrane lipids, such as glycerophospholipids, sphingolipids and sterols, using mass spectrometry ionization patterns are disclosed.. .
University Of Maryland, Baltimore


Mass spectrometry using laserspray ionization


Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (lsi). Lsi can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 daltons.
Wayne State University


Msia-srm assay for biomarker analysis


The present disclosure provides assays, methods and signature peptides for the identification and quantification of biomarkers in a sample. In particular, the present disclosure relates to the development of mass spectrometric immunoassays with selected reaction monitoring mass spectrometry (msia-srm ms) platforms for biomarker analysis.
Nuclea Biotechnologies, Inc.


Probe displacement measuring apparatus, ionization apparatus including the same, and mass spectrometry apparatus


A probe displacement measuring apparatus includes a cantilever probe, a light irradiation unit configured to irradiate the probe with light, a light receiving element configured to receive reflected light obtained by reflecting light emitted by the light irradiation unit on a surface of the probe as a spot, and a displacement obtaining unit configured to obtain displacement of the probe in accordance with a position of the spot on the light receiving element. The light receiving element has first and second light receiving surfaces divided by a straight division line.
Canon Kabushiki Kaisha


Remote laser ablation electrospray ionization mass spectrometry


In various embodiments, a device may generally comprise a remote ablation chamber comprising an inlet and an outlet, a laser to deposit energy into a sample in the chamber to ablate the sample and generate ablation products in the chamber, a transport device in fluid communication with the outlet, an ionization source to ionize the ablation products to produce ions, and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation products or the ions may be transported in a fluid stream from the ablation chamber through the transport device.
The George Washington University


Mass correction


Disclosed is a method of mass spectrometry comprising the steps of: providing a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components as a function of retention time; chromatographically separating a sample, said sample containing at least some of said matrix components and one or more analyte components; analysing said sample at a plurality of retention times to obtain sample data, said sample data comprising one or more physico-chemical properties of one or more sample components as a function of retention time; and calculating one or more error values as a function of retention time based on a comparison between said sample data and said matrix data.. .
Micromass Uk Limited


Ultrathin calcinated films on a gold surface for highly effective laser desorption/ ionization of biomolecules


A nanoscale calcinated silicate film fabricated on a gold substrate for highly effective, matrix-free laser desorption ionization mass spectrometry (ldi-ms) analysis of biomolecules. The calcinated film is prepared by a layer-by-layer (lbl) deposition/calcination process wherein the thickness of the silicate layer and its surface properties are precisely controlled.
The Regents Of The University Of California


Data processing system for chromatographic mass spectrometry


For peak a detected on a chromatogram created based on data obtained by a product ion scan measurement of one characteristic ion species originating from a target compound, a mass spectrum is extracted, and this mass spectrum is subjected to a database search to extract candidates of the compound as a primary search result. Subsequently, for peak b detected on a chromatogram created based on data obtained by a product ion scan measurement of another characteristic ion species originating from the same target compound, a mass spectrum is extracted, and this mass spectrum is subjected to a database search, with the search range limited to the candidates extracted in the search result based on peak a, to further reduce the number of candidates.
Shimadzu Corporation


Glass sheet and chemically strengthened glass sheet


The present invention relates to a glass sheet having an amount of fluorine contained in the glass of more than 0.23 mol %·μm and 21 mol %·μm or less on a depth-direction profile by secondary ion mass spectrometry (sims) in which a horizontal axis expresses depth and a vertical axis expresses fluorine concentration (mol %). According to the glass sheet of the present invention, warpage after chemical strengthening can be reduced and polishing treatment or the like before the chemical strengthening can be simplified or omitted..
Asahi Glass Company, Limited


Protein products and methods for making the same


According to one embodiment, a protein product may include a mixture of water and particulate matter comprising protein. The mixture may include medium chain aldehydes and pyrazines.
Kraft Foods Group Brands Llc


Nanoparticulate assisted nanoscale molecular imaging by mass spectrometry


Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source..

Proteomic biomarkers of sepsis in elderly patients


A proteomic expression platform to identify age-related sepsis risk is disclosed using patients with community-acquired pneumonia. A semi-quantitative plasma proteomics workflow was applied which incorporated tandem immuno affinity depletion, itraq labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled to high resolution mass spectrometry.

Icr cell operating with a duplexer


An icr cell (01) operates with a duplexer (08), which is an integral part of a transmission and receiving device (09) of an ft-icr mass spectrometry device. The device transmits a transmitter (03) voltage to at least one electrode (11) of the icr cell during an ion excitation phase and protects a preamplifier (04) from overvoltage.

Enhanced spray formation for liquid samples


Methods and systems for generating ions from a liquid sample for mass spectrometry are provided herein. In various aspects, the methods and systems can enhance the break-up of a jet of the liquid sample upon injection into an ionization chamber.

Multi-element isotopic measurement by direct coupling of a multi-cycle isotachophoresis technique and a mass spectrometry technique


A method for separating electrically charged species contained in a solution by an isotachophoresis method applied in an electrophoresis device, the isotachophoresis method being coupled to isotopic measurement using a mass spectrometer. The method notably comprises a step of stopping the voltage applied to the terminal of the electrophoresis capillary and transient application of a counter-pressure making it possible to utilize the length of the capillary several times and extend the separation distance artificially..

System and analyzing tissue for the presence of cancer using bio-marker profiles


A system and method for intra-operative sample analysis including acquiring a tissue sample, preparing the tissue sample for mass spectrometry imaging, conducting a mass spectrometry imaging procedure on the tissue sample to produce an image, and analyzing the image to determine the presence or absence of a bio-marker.. .

Methods, apparatus, and system for mass spectrometry


A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments.
The Massachusetts Institute Of Technology


Vacuum system


The invention concerns a vacuum system, comprising a first vacuum chamber and a second vacuum chamber, the first vacuum chamber being evacuated by a first vacuum pump, in particular a turbomolecular pump, the first and the second vacuum chamber being connected by a passage, wherein the passage is surrounded by a sealing arrangement comprising an inner seal and an outer seal with a plenum positioned between the inner seal and the outer seal, the plenum being evacuated by a support vacuum pump, and wherein at least one sealing face of the inner seal consists of the wall material of the first or the second vacuum chamber, in particular the inner seal being formed by direct contact between the wall material of the first vacuum chamber and the wall material of the second vacuum chamber. Additionally, the invention concerns a mass spectrometry system..
Thermo Fisher Scientific (bremen) Gmbh


Automatic determination of demultiplexing matrix for ion mobility spectrometry and mass spectrometry


Multiplexed ion mobility spectrometry (ims), mass spectrometry (ms) such as time-of-flight mass spectrometry (tofms), or hybrid im-ms is carried out on a sample, and the resulting measurement data are deconvoluted. A pulse sequence controlling ion pulsing is utilized in conjunction with the multiplexing.
Agilent Technologies, Inc.


Methods for detecting vitamin c by mass spectrometry


Provided are methods for determining the amount of vitamin c in a sample using mass spectrometry. The methods generally involve ionizing vitamin c in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin c in the sample..
Quest Diagnostics Investments Incorporated


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Biomarkers of autism spectrum disorder


Methods for identifying metabolic signatures in blood plasma which are unique to autism are described herein. Samples are analyzed using multiple chromatographic-mass spectrometry-based techniques to orthogonally measure a broad range of small molecular weight metabolites differentially produced in autistic patient samples versus non-autistic control samples.
Stemina Biomarker Discovery, Inc.


Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor


Disclosed herein are isobaric labeling reagent sets useful for multiplexed quantitation of peptides. The isobaric labeling reagent sets include a collection of at least two isobaric labeling reagents having first and second reporter groups with the same nominal mass but different isotopic substitutions and consequently different exact masses.
Thermo Finnigan Llc


Mass spectrometer


The objective of the present invention is to improve the robustness, sensitivity, and maintainability of a mass spectrometer to which a liquid chromatograph can be connected. This mass spectrometer includes: an ion source; a mass spectrometry unit; a plurality of flat plates used as electrodes having openings through which ions can be introduced to the mass spectrometer from an orthogonal direction along an ion introduction axis; a porous member provided between the mass spectrometry unit and the plurality of flat plates; and a mechanism for feeding gas to the plurality of flat plates for the side opposite from the ion introduction direction; the plurality of flat plates being disposed under atmospheric pressure, and the plurality of electrodes being set at a temperature higher than room temperature..
Hitachi High-technologies Corportion


Frequency scan linear ion trap mass spectrometry


An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an rf frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the rf to x and y electrodes.. .
Academia Sinica


Zero voltage mass spectrometry probes and systems


The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer).
Purdue Research Foundation


Method for computer-assisted analysis of one or more tissue sections of the human or animal body


A method for computer-assisted analysis of one or more tissue sections of the human or animal body for preparing a digital stain test is provided. During the digital stain test, tissue zones in a tested tissue section with a predetermined clinical picture are detected.
Universitat Bremen


Early detection of hepatocellular carcinoma in high risk populations using maldi-tof mass spectrometry


Hepatocellular carcinoma (hcc) is detected in a patient with liver disease. mass spectrometry data from a blood-based sample from the patient is compared to a reference set of mass-spectrometry data from a multitude of other patients with liver disease, including patients with and without hcc, in a general purpose computer configured as a classifier.
Biodesix, Inc.


On-site mass spectrometry for liquid and extracted gas analysis of drilling fluids


An example method for analyzing drilling fluid used in a drilling operation within a subterranean formation may include receiving a drilling fluid sample from a flow of drilling fluid at a surface of the subterranean formation. A chemical composition of the drilling fluid sample may be determined using a mass spectrometer.
Halliburton Energy Services, Inc.


Method of recording adc saturation


A method of mass spectrometry is disclosed comprising digitising a plurality of individual signals or transients and summing the plurality of digitised signals or transients or data relating to the plurality of digitised signals or transients to generate a composite mass spectral data set. The method further comprises determining in relation to the composite mass spectral data set an indication of the proportion of instances that intensity values relating to the individual digitised signals or transients either: (i) exceeded or approached a threshold value; (ii) suffered from saturation or approached saturation; or (iii) resulted from the dynamic range of an ion detector system being exceeded or approached..
Micromass Uk Limited


Imaging mass spectrometry


A method of performing imaging mass spectrometry of a sample. The method comprises performing a first mass analysis of the sample using a first mass analyzer comprising a multi-pixel ion detector to obtain first mass spectral data representative of pixels of the sample.
Thermo Fisher Scientific (bremen) Gmbh


Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards


A method for absolute protein or peptide quantitation by mass spectroscopy. A sample containing a protein or peptide of interest is prepared for mass spectroscopy analysis.
Pierce Biotechnology, Inc.


Method for obtaining mass spectrum of ions generated at constant temperature by measuring total ion count, and use of matrix for quantitative analysis using maldi mass spectrometry


A method for obtaining a mass spectrum of reproducible ions generated at a constant temperature by measuring a total ion count, and the use of a matrix for quantitative analysis using maldi mass spectrometry are disclosed. More particularly, a method for measuring a mass spectrum of ions generated at a constant temperature may include selecting only mass spectra having the same total ion count, among multiple mass spectra obtained from ions formed by applying energy to a specimen having a sample mixed therein..
Asta Co., Ltd.


Toner, two-component developer, and color-image forming apparatus


A toner, including a binder resin, a release agent, and a colorant, wherein a total amount of hydrocarbon compounds having 33 to 35 carbon atoms in the toner measured by ion attachment mass spectrometry (iams) is 40% to 70% in terms of a signal intensity ratio.. .

High sensitivity quantitation of peptides by mass spectrometry


The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels).
Anderson Forschung Group, Inc.


Method and device for measuring permeation by mass spectrometry


D) determining the permeation of the material (m) to said gas, from the measurement of the target gas present at instant (t) corrected with the correction factor at instant (t).. .

Systems for bioagent identification


The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials.
Ibis Biosciences, Inc.


Miniature charged particle trap with elongated trapping region for mass spectrometry


A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles..
The University Of North Carolina At Chapel Hill


System and detection and quantification by mass spectrometry and by activating ionised molecular species


Disclosed is a system and method of mass spectrometry, including: a. Ionising an analyte to form a precursor ion (a) having a mass-to-charge ratio (m/z), in which m represents the mass and z the electric charge number; b.
Institut National De La Recherche Agronomique - Inra


Method for time-alignment of chromatography-mass spectrometry data sets


A method is disclosed for adjusting the time scale of chromatography-mass spectrometry data sets, wherein a time scale of a first data set is used as a reference time scale and wherein a time scale of at least one second data set is adapted to the reference time scale comprising the. The steps of the method include identifying feature groups in the first data set by evaluating intensities of consecutive points of the first data set; identifying feature groups in the second data set by evaluating intensities of consecutive points of the second data set; matching feature groups of the first data set to feature groups of the second data set, and determining a corrected time scale for the second data set based on time differences between feature groups in the first data set and matching feature groups in the second data set..
Thermo Fisher Scientific (bremen) Gmbh


Projection-type charged particle optical system and imaging mass spectrometry apparatus


Provided is a projection-type charged particle optical system in which a projection magnification can be changed while a decrease in the accuracy in measuring a mass-to-charge ratio is being suppressed. A projection-type charged particle optical system according to the present invention includes a first electrode disposed so as to face a sample and having an opening formed therein for allowing a charged particle to pass, a second electrode disposed on a side of the first electrode opposite to where the sample is disposed and having an opening formed therein for allowing the charged particle to pass, and a flight-tube electrode disposed such that the charged particle that has been emitted from the sample and has passed through the second electrode enters the flight-tube electrode and being configured to form a substantially equipotential space thereinside.
Canon Kabushiki Kaisha


Methods for detecting vitamin d metabolites by mass spectrometry


Provided are methods of detecting the presence or amount of a vitamin d metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin d metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin d metabolite in the sample.
Quest Diagnostics Investments Incorporated


Detecting targets using mass tags and mass spectrometry


Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses.
Ventana Medical Systems, Inc.


Mass labels


The present invention provides set of two or more mass labels, wherein each mass label in the set has the same integer mass as every other label in the set, and each mass label in the set has an exact mass which is different to the mass of all other mass labels in the set such that all the mass labels in the set are distinguishable from each other by mass spectrometry.. .
Electrophoretics Limited


Method for analysis of compounds with amino group and analytical reagent therefor


The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-n-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity.
Ajinomoto Co., Inc.


Method of detection of gram-negative bacteria periplasmic space and cell wall outer membrane proteins by mass spectrometry


The invention relates to a method of detection of gram-negative bacteria periplasmic space and cell wall outer membrane proteins by mass spectrometry, wherein the periplasmic space and cell wall outer membrane proteins are extracted from the bacteria, and the proteins to be detected are stabilized by an inhibitor and/or a substrate of the given protein, the proteins are then dissolved, placed onto a maldi-tof plate, covered with matrix solution, measured by maldi-tof mass spectrometry, and the resulting spectra are compared to the reference peaks of the given protein. Preferably, the proteins are beta-lactamases and their detection can be used to quickly determine the bacterial resistance against beta-lactam antibiotics, minimizing the false-positive results..
Univerzita Karlova V Praze, Lekarska Fakulta V Plzni


Reduction of ambient gas entrainment and ion current noise in plasma based spectrometry


In a plasma source configured for producing sample atoms for analysis, such as by optical emission spectrometry or mass spectrometry, a plasma torch includes a torch exit in a chamber. A baffle is positioned between the torch exit and an opposing boundary.
Agilent Technologies, Inc.


Intelligent dynamic range enhancement


A method of mass spectrometry is disclosed comprising transmitting ions and obtaining first mass spectral data and automatically determining during an acquisition whether the first mass spectral data suffers from saturation or is approaching saturation. If a determination is made during an acquisition that the first mass spectral data suffers from saturation or is approaching saturation then the method further comprises automatically changing or altering the intensity of ions which are detected by an ion detector and obtaining second mass spectral data.
Micromass Uk Limited


Srm/mrm assay for the insulin receptor protein


Specific peptides, and derived ionization characteristics of the peptides, from the insulin receptor protein (ir), and its isoforms ir-a and ir-b, that are particularly advantageous for quantifying the ir protein, ir-a isoform and/or ir-b isoform, directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


Enhanced sensitivity of detection in electrospray ionization mass spectrometry using a post-column modifier and a microfluidic device


A microfluidic liquid chromatography-electrospray ionization (lc-esi) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent.
Waters Technologies Corporation


Integrated mass spectrometry systems


The disclosure features mass spectrometry systems that include: an ion source; a module featuring an ion trap, an ion detector, and a module housing that at least partially surrounds the ion trap and the ion detector; and a vacuum pump featuring a housing having a recess dimensioned to receive the module, so that when the module is positioned within the recess of the vacuum pump housing, a portion of the module is surrounded by the vacuum pump housing, and during operation of the system, the ion source, ion trap, ion detector, and vacuum pump are connected along a common gas flow path and heat is transferred from the vacuum pump to the module.. .
908 Devices Inc.


Method and reacting ions


A method of mass spectrometry is disclosed having a mode comprising: providing a source of precursor ions and reagent ions for reacting with said precursor ions; providing a reaction region downstream of said source; providing an ion mobility separator between said source and said reaction region; providing a bypass cell between said source and said reaction region for guiding ions from said source to said reaction region without the ions passing through said ion mobility separator; guiding said precursor ions from said source, through said ion mobility separator so that said precursor ions separate according to their ion mobility and into said reaction region; and guiding said reagent ions from said source, through said bypass cell and into said reaction region; wherein the reagent ions react with the precursor ions within the reaction region to produce product ions.. .
Micromass Uk Limited


Mass spectrometry measuring vitamin b6 in body fluids


Provided are methods of detecting the presence or amount of the active form of vitamin b6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.. .
Quest Diagnostics Investments Incorporated


Pathology interface system for mass spectrometry


A diagnostic system and method that includes a non-transitory computer readable medium storing machine executable instructions executable by the processor for altering tissue images, the instructions that further includes an input interface configured to receive a plurality of tissue images, the input interface generating enhanced resolution images from the plurality of tissue images for viewing, an annotation interface for positioning coordinates of interest on the enhanced resolution images, and a matrix model configured to evaluate the coordinates of interest on the enhanced resolutions to generate discrete coordinates, the matrix model using the discrete coordinates in performing mass spectrometer analysis to form at least one viewing image. The system also includes a user interface configured to provide at least one viewing image to a user at the display..
Vanderbilt University


Versatile ambient ionization-based interface for lc/ms


An apparatus (10) for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (16), which defines a flow passage (18) and is configured to supply the liquid sample. The fluid conduit (16) has an outer surface and a micro-hole (30) through the outer surface into the flow passage (18).
Ohio University




Mass Spectrometry topics:
  • Mass Spectrometry
  • Spectrometry
  • Spectrometer
  • Mass Spectrometer
  • Chromatograph
  • Extrapolate
  • Hydrocarbon
  • High Resolution
  • Chromatography
  • Quantitative
  • Drug Resistance
  • Phosphorylation
  • Peptide Sequence
  • Formaldehyde
  • Amino Acid


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