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Tandem mass spectrometer and mass spectrometric method

Date/App# patent app List of recent Mass Spectrometry-related patents
08/28/14
20140244180
 Shape analysis and mass spectrometry of individual molecules by nanomechanical systems patent thumbnailnew patent Shape analysis and mass spectrometry of individual molecules by nanomechanical systems
The spatial distribution of mass within an individual analyte can be imaged—in real time and with molecular-scale resolution—when it adsorbs onto a nanomechanical resonator. Each single-molecule adsorption event induces discrete, time-correlated perturbations to the modal frequencies of the device.
08/28/14
20140242711
 Vitamin b2 detection by mass spectrometry patent thumbnailnew patent Vitamin b2 detection by mass spectrometry
Methods are described for measuring the amount of a vitamin b2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin b2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques..
08/28/14
20140239173
 Mass spectrometer patent thumbnailnew patent Mass spectrometer
In order to solve a problem in a mass spectrometry that a distribution of an emitted ion and a substance distribution on the measurement object surface are different from each other, which is due to a shaded portion of a irregular surface which falls under a shadow of primary beam, a primary ion optical system of the present apparatus includes a deflection unit configured to deflect the primary ion in such a manner that the primary ion intersects a flight space of the secondary ion in the course of flight.. .
08/28/14
20140239172
 Method and apparatus for mass spectrometry patent thumbnailnew patent Method and apparatus for mass spectrometry
A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (mr tof) mass spectrometry..
08/28/14
20140239170
 Tandem mass spectrometer and mass spectrometric method patent thumbnailnew patent Tandem mass spectrometer and mass spectrometric method
An ion trap is provided between a collision cell and a time-of-flight mass separator. During a time period in which precursor ions derived from the same compound are selected with a quadrupole mass filter, a collision energy is changed from one to another.
08/28/14
20140239169
 Detection of membrane protein-therapeutic agent complexes by mass spectrometry patent thumbnailnew patent Detection of membrane protein-therapeutic agent complexes by mass spectrometry
According to the present invention, there is provided a method of detecting a complex comprising a membrane protein bound to a therapeutic agent by mass spectrometry. The method comprises: (a) providing a solution comprising a detergent micelle in which said complex is contained; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the complex is released from the micelle; (d) ionising the complex; (e) resolving the ionised complex using the mass analyser; and (f) detecting the resolved complex using the detector.
08/21/14
20140236497
 Methods and systems for experimental set-up and data analysis in targeted proteomics applications patent thumbnailMethods and systems for experimental set-up and data analysis in targeted proteomics applications
The invention relates to the analysis of compounds with mass spectrometry and more particularly to instruments, substances, and methods for polypeptide analysis, in particular in targeted proteomics applications and based on indexed retention time as peptide specific property. The method of chemical analysis comprises the steps of: a) providing a first complex sample comprising a set of at least two reference peptides associated to an indexed retention time scale (irt), as well as at least one further peptide; b) performing lc-ms on said complex sample and determining the empirical retention time values (rte) of the reference peptides and of the at least one further peptide; c) translating the empirical retention time values (rte) of the reference peptides and of the at least one further peptide into the indexed retention time scale and associating to each reference peptide a reference indexed retention time value (irtr) and to the at least one further peptide an associated indexed retention time value (irta); d) providing a second complex sample comprising at least one polypeptide as well as said set of the at least two reference peptides; e) performing lc-ms on said second complex sample and determining the empirical retention time values (rte) of the reference peptides; f) translating the empirical retention time values (rte) of the reference peptides into the indexed retention time scale by numerically adapting the transformation function for the conversion of the retention time values (rte) into indexed retention time values such that the calculated indexed retention time values (irte) calculated based on the measured retention time values (rte) of the reference peptides match the assigned indexed retention time values (irtr) of the reference peptides; g) determining the predicted empirical retention time value (rtp) of the at least one further peptide by using the numerically adapted transformation function determined in step f)..
08/21/14
20140235471
 Global proteomic screening of random bead arrays using mass spectrometry imaging patent thumbnailGlobal proteomic screening of random bead arrays using mass spectrometry imaging
Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate.
08/21/14
20140235464
 Detection and quantification of biomolecules using mass spectrometry patent thumbnailDetection and quantification of biomolecules using mass spectrometry
The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry.
08/21/14
20140234989
 Methods for detecting dihydroxyvitamin d metabolites by mass spectrometry patent thumbnailMethods for detecting dihydroxyvitamin d metabolites by mass spectrometry
Provided are methods of detecting the presence or amount of a dihydroxyvitamin d metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin d metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin d metabolite in the sample.
08/21/14
20140234880
Methods of detection of cancer using peptide profiles
The disclosed methods address the identification and monitoring of cancer in a subject using serum peptide profiles. Such profiles allow the detection of the differential presence of certain serum peptide markers in comparison with controls.
08/21/14
20140231641
Generation of model of composition of petroleum by high resolution mass spectrometry and associated analytics
A method to determine the model-of-composition of a vacuum resid in which the resid is separated into fractions including the dao fraction which is then separated into chemical classes including saturates, aromatics, sulfides and polars by a combination of soft ionization methods. The results of the ionization analyses are reconciled with other analyses such as bulk analysis, then consolidated to generate the modeol-of composition..
08/21/14
20140230517
Quality control reagents and methods
The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (ms) and/or liquid chromatography (lc) functionalities..
08/14/14
20140227704
Methods for rapid identification and quantitation of nucleic acid variants
There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products..
08/14/14
20140224979
Mass distribution spectrometry method and mass distribution spectrometer
The present invention provides a mass distribution spectrometry which reduces an influence of the dispersion in the times at which ionizing beams irradiate a sample, on a mass spectrometry result, and can measure the mass distribution with high reliability. The mass distribution spectrometry is a mass spectrometry which includes irradiating the sample with a primary ion beam and detecting generated secondary ions, wherein this primary ion beam has a spread toward a direction perpendicular to a travelling direction, has a path length of each primary ion contained in the primary ion beam between a primary ion source and a surface of the sample adjusted by deflecting a trajectory, and is obliquely incident on the surface of the sample..
08/14/14
20140224976
Mass spectrometric determination of fatty acids
The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry..
08/14/14
20140224975
Method of operating a mass filter in mass spectrometry
Disclosed herein is a mass spectrometry method having steps of: transmitting ions from an ion source through a mass filter; processing ions received from the mass filter in a discontinuous ion optical device downstream of the mass filter; operating the mass filter for a plurality of periods in a mass/charge ratio (m/z) filtering mode to transmit ions in one or more selected ranges of m/z to the discontinuous ion optical device; and operating the mass filter in a broad mass range mode transmitting ions of a mass range substantially wider than any mass range transmitted in the m/z filtering mode during one or more periods in which the discontinuous ion optical device is not processing ions from the mass filter. Utilization of this method assists to reduce contamination in the mass filter..
08/14/14
20140224974
Photo-dissociation of proteins and peptides in a mass spectrometer
A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.. .
08/14/14
20140224973
Mass spectrometer and mass spectrometric method
A mass spectrometry using helium as cooling gas is performed to obtain a first mass spectrum (s1), and another mass spectrometry using argon, which is heavier than helium, as cooling gas is performed to obtain a second mass spectrum for the same sample (s2). Due to the difference between the two gases in terms of the effect of promoting dissociation of modifications, an ion peak originating from a target compound from which all the modifications have been dissociated will appear with a higher intensity on the second mass spectrum.
08/07/14
20140222348
Mass spectrometry
The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (ms)n devices.. .
08/07/14
20140221223
Use of probes for mass spectrometric identification and resistance determination of microorganisms or cells
This invention pertains to identifying one or more hybridization probes sequestered within (or optionally released from the intact) cells or microorganisms by mass spectrometry to thereby determine a trait of the cells or microorganisms and/or to identify the cells or microorganisms themselves. The cells or microorganisms can come from a subject and the information obtained from the mass spectrometry analysis may, if clinically relevant, optionally be used to diagnose and/or treat the subject..
08/07/14
20140217282
Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers
Mass spectrometry cells include one or more interleaved magnetostatic and electrostatic lenses. In some examples, the electrostatic lenses are based on electrical potentials applied to magnetostatic lens pole pieces.
08/07/14
20140217280
Mass spectrometry device
Vacuum gauges are arranged in intermediate vacuum chamber and analytical chamber 10 in which collision cell is installed, and gas pressure determination unit determines whether or not the gas pressures detected by vacuum gauges are at or below a threshold value prior to analysis, and issues an alert if they are at or below the threshold value. If the supply of cid gas into collision cell stagnates, the quantity of cid gas flowing out into the analytical chamber will decrease, and the degree of vacuum in the analytical chamber will thus become too high.
08/07/14
20140217276
Sequential low/high-resolution library search
Provided herein are systems and method for using unit mass library searches for sample identification in accurate mass spectrometry. In general, the systems and methods described herein: (a) obtain an accurate mass spectrum of a sample; (b) calculate a unit mass spectrum based on the accurate mass spectrum; and (c) conduct a unit mass library search, based on the calculated unit masses, to obtain at least one candidate species to thereby identify the sample.
07/31/14
20140213478
Srm/mrm assay for the receptor tyrosine-protein kinase erbb-4 protein (her4)
Ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded. A protein sample is prepared from the biological sample using the liquid tissue™ reagents and protocol and the her4 protein is quantitated in the liquid tissue™ sample by srm/mrm mass spectrometry by quantitating in the protein sample at least one or more of the peptides described.
07/31/14
20140212981
Methods and systems for determining the amount of thiopurine metabolites in a sample
Disclosed are methods and systems for the analysis of thiopurine drug metabolites in a sample using liquid chromatography/mass spectrometry.. .
07/31/14
20140212980
Hydrophilic thiol probe
Wherein r1 represents a linker group, and r2 represents a substituted ammonium group or a substituted amino group. A mass spectrometry method for a protein, comprising the steps of: obtaining a modified protein by reacting the thiol probe with a protein to be subjected to mass spectrometry; and subjecting the modified protein to mass spectrometry..
07/31/14
20140212906
Screening method
A method for screening for variant peptides uses mass spectrometry (ms). A system and a kit may be used for performing the method.
07/31/14
20140209814
Fragmentation methods for mass spectrometry
Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ecd) and positron capture dissociation (pcd), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ecd often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable.
07/24/14
20140206776
Mrm/srm assay for death receptor 5 protein
Specific peptides, and derived ionization characteristics of those peptides from death receptor 5 (dr5) protein are provided that are particularly advantageous for quantifying the dr5 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/24/14
20140206775
Srm/mrm assay for the fatty acid synthase protein
Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/24/14
20140206570
Characterization of biochips containing self-assembled monolayers
The present invention relates to a method of characterizing biochips with matrix-assisted laser desorption/ionization and time of flight mass spectrometry (maldi-tof ms).. .
07/24/14
20140206094
Maldi mass spectrometry method
The problem is to provide a maldi mass spectrometry method that can be used for a mass spectrometry method by a general maldi method with which it is possible to measure multiple molecules to be measured that are contained in a sample quantitatively in a short period of time with good efficiency compared with conventional methods. The problem is solved by a maldi mass spectrometry method for a sample containing multiple molecules to be measured, which is a maldi mass spectrometry method characterized in that the multiple molecules to be measured are a saccharide mixture, a glycopeptide mixture, a glycopeptide-peptide mixture, a glycoprotein mixture, or a glycoprotein-protein mixture, and that a quantitative mass spectrum of the multiple molecules to be measured is obtained from an arbitrary point in the sample to be measured where a signal is detected without measuring and integrated averaging the entire sample to be measured..
07/24/14
20140206091
Cross-linking compositions and related methods of isotope tagging of interacting proteins and analysis of protein interactions
An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (itip), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the ms/ms spectrum.
07/17/14
20140200330
Isolation of phosphoproteins, glycoproteins and fragments thereof
The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. A lanthanide metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups.
07/17/14
20140199717
Multiplex mrm assay for evaluation of cancer
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (er), progesterone receptor (pr), and/or antigen ki67 (ki67) proteins that are particularly advantageous for quantifying the er, pr, and/or ki67 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/17/14
20140199716
Isotopic recoding for targeted tandem mass spectrometry
Aspects of the present disclosure include methods for detecting a low abundance protein and methods for identifying a site of n-glycosylation on a protein. In practicing methods according to certain embodiments, a eukaryotic cell is contacted with an isotopic labeling composition and isotopically labeled n-glycosylated peptides obtained from the eukaryotic cell are assessed by liquid chromatography-tandem mass spectrometry.
07/03/14
20140183355
High pressure mass spectrometry systems and methods
Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
07/03/14
20140183352
Parallel mass analysis
A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device.
07/03/14
20140183350
Compact mass spectrometer
Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
07/03/14
20140183347
Multiple ion injection in mass spectrometry
This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed.
06/26/14
20140179010
Methods of detecting reverse triiodothyronine by mass spectrometry
Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample..
06/26/14
20140175276
Tandem mass spectrometer and tandem mass spectrometry method
The invention relates to a tandem mass spectrometer comprising an ionisation source (1) that can produce ions; a mass analyser comprising an ion trap (2) arranged in such a way as to receive ions from the ion source and detection means that can detect ions leaving the ion trap according to the mass m to load z (m/z) ratio thereof; ion activation means for activating ions that can fragment at least some of the ions trapped in the ion trap; and coupling means arranged between the ion trap and said ion activation means. According to the invention, the ion activation means consist of a glow discharge lamp (4) that can generate a light beam oriented towards the ion trap (2), said light beam being electromagnetic radiation in the vacuum ultraviolet wavelength range with photon energies of between 8 ev and 41 ev in such a way as to fragment at least some of the ions trapped in the ion trap (2)..
06/26/14
20140175275
Mass spectrometry assay for congenital adrenal hyperplasia
Methods are provided for detecting the amount of one or more cah panel analytes (i.e., pregnenolone, 17-oh pregnenolone, progesterone, 17-oh progesterone, dehydroepiandrosterone (dhea), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more cah panel analytes in a sample and quantifying the generated ions to determine the amount of one or more cah panel analytes in the sample.
06/19/14
20140170759
System and method for determining amino acid sequence of polypeptide
This invention discloses systems and methods for determining the sequence of amino acids in a short peptide chain that constructs a protein. The protein is firstly hydrolyzed to various short peptides and amino acid enantiomers.
06/19/14
20140170146
Methods for multiplexed drug evaluation
Methods for multiplexed delivery of agents to a solid tissue in vivo followed by assessment of efficacy with mass spectrometry are described.. .
06/19/14
20140166875
Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.. .
06/12/14
20140162902
Cell-based materials and methods for defining pharmacogenetic differences in drug metabolism
Cell lines harboring a range of polymorphisms using recombinant cytochrome p450 or other chemical-metabolizing enzymes in a parent cell line that is minimally expressing or devoid of its own cytochrome p450 protein or other chemical-metabolizing enzymes of interest can be placed into an array format to enable high throughput screening of one or more chemicals for cyp450 or other enzyme-dependent metabolism (fig. 9).
06/12/14
20140162371
Methods for detecting vitamin d metabolites by mass spectrometry
Provided are methods of detecting the presence or amount of a vitamin d metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin d metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin d metabolite in the sample.
06/12/14
20140162298
Immobilized enzymatic reactor
An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide.
06/12/14
20140162248
Use of aptamers in liquid chromatography and liquid chromatography - mass spectrometry
The present disclosure relates to the use of aptamers in solid phase extraction, chromatography and chromatography-mass spectrometry systems. More specifically, the present disclosure relates to the use of aptamers in spe and chromatography systems to selectively retain, extract and/or pre-concentrate target molecule(s) having a specific affinity for the particular aptamer(s).
06/12/14
20140162068
Intermediate transfer member and electrophotographic apparatus
The intermediate transfer member is an intermediate transfer member for electrophotography, including a surface layer having a surface for carrying toner, in which: the surface layer contains a fluorine-modified curable resin having one of an acryloyl group and a methacryloyl group, and electro-conductive inorganic particles; and the surface layer has a ratio of the number of atoms of an element derived from the electro-conductive inorganic particles to the total number of atoms to be detected through analysis of the surface by x-ray photoelectron spectroscopy of 2.5 atomic % or more and 10 atomic % or less, and a peak detected at a position corresponding to a mass-to-charge ratio [m/z] of one of m/z=71 and m/z=85 in analysis of the surface by time-of-flight secondary ion mass spectrometry.. .
06/12/14
20140158881
Compositions, methods, and kits for quantifying target analytes in a sample
A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known quantity of a second calibrator, and potentially comprising a target analyte. The first known quantity and the second known quantity are different, and wherein the first calibrator, the second calibrator, and the target analyte are each distinguishable in the single sample by mass spectrometry.
06/12/14
20140158879
Method and system of identifying a sample by analysing a mass spectrum by the use of a bayesian inference technique
A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured data set from a sample using a mass spectrometer, deconvoluting the measured data set by bayesian inference to produce a family of plausible deconvoluted data sets, inferring an underlying deconvoluted data set from the family of plausible deconvoluted data sets and using the underlying deconvoluted data set to identify and/or characterise the sample..
06/05/14
20140156612
Preparing lc/ms data for cloud and/or parallel image computing
Functionality is described for data management and querying lc/ms spectrometry data, therefore making it easier to store, retrieve, transfer, and process the mass spectrometry data. The functionality transforms a plurality of raw lc/ms files obtained from a biological experiment into a set of lc/ms images on a common m/z and rt grid compatible for image processing (e.g., time alignment, peak detection and quantification, differential analysis, etc.).
06/05/14
20140156224
Single-protein nanomechanical mass spectrometry in real time
Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (g) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution..
06/05/14
20140156206
Detection and quantification of polypeptides using mass spectrometry
The invention relates to the detection and quantification of polypeptides using mass spectrometry. Specifically, the invention provides a method for testing whether a target polypeptide is present in a sample of a set of polypeptides, a method for deriving a value for distinguishing polypeptides of a set of polypeptides from each other, a database containing values for distinguishing each polypeptide of a set of polypeptides from each other, and an apparatus for configuring a mass scan of a mass spectrometer to test whether a target polypeptide of a set of polypeptides is present in a sample of the set..
06/05/14
20140151548
Matrix for maldi mass spectrometry and maldimass spectrometry method
Provided is a matrix for maldi mass spectrometry that has a high ability of ionizing low-molecular-weight compounds, and makes it possible to make measurement in a negative ion mode. The matrix is a matrix for mass spectrometry that contains one or more compounds selected from the group consisting of compounds each represented by the following general formula (i), (ii) or (iii), and their salts thereof.
06/05/14
20140151541
Electrokinetically controlled calibrant delivery
An electrokinetic pump can be used to deliver calibrant (“lock mass”) ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery.
05/29/14
20140147921
Microsecond time-resolved mass spectrometry
A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length.
05/29/14
20140147878
Lc-ms separation and detection of vitamin d metabolites
Systems, kits, and methods for quantitation of metabolites of vitamin d by liquid chromatography-mass spectrometry (lc-ms). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([m+h]+) for the vitamin d metabolites in the ionization source (e.g., electrospray ionization (“esi”)).
05/29/14
20140145166
Light-emitting element, light-emitting device, electronic device, and lighting device
To provide a light-emitting element with high emission efficiency. In a light-emitting element including an organic compound between a pair of electrodes, the molecular weight x of the organic compound is 450 or more and 1500 or less, and the absorption edge of the organic compound is at 380 nm or more.
05/29/14
20140145073
Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy
The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion.. .
05/22/14
20140141466
Ion generation using wetted porous material
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.. .
05/22/14
20140138541
Dual source mass spectrometry system
A dual source mass spectrometer system (10) is operable in a first mode with an lc source [lc/ms] (12) and in a second mode with a gc source [gc/ms] (18). The gc source inputs into an ion source chamber (22) for delivering the ionized output from the gc source to the mass spectrometer.
05/22/14
20140138538
Resolution and mass range performance in distance-of-flight mass spectrometry with a multichannel focal-plane camera detector
A distance-of-flight mass spectrometer (dofms) includes an ion source, a field-free region, an extraction region in which ions are accelerated, and a spatially-selective detector for spatially selectively detecting ions extracted by the extraction region. A method for operating a distance-of-flight mass spectrometer dofms comprises controlling a detection time in such a way as to permit ions with progressively greater mass-to-charge (m/z) ratios to enter the extraction region of the dofms at positions which will permit the ions with progressively greater m/z ratios to enter the detector of the dofms, generating a component mass spectrum at each selected value of detection time, and then assembling a composite mass spectrum by shifting the distance-of-flight axis of each component mass spectrum by a distance corresponding to the change in detection time..
05/15/14
20140134654
Systems and apparatus for indicating risk of coronary stenosis
A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one cholesteryl ester measured in a blood sample collected from said subject; and then (b) inputting the age and gender of said subject; and then (c) generating in said computer from said cholesteryl ester level input, said age input and said gender input a prediction of risk and/or an indication of extent of coronary stenosis blood sample by mass spectrometry.. .
05/15/14
20140134642
Characterization of biochips containing self-assembled monolayers
The present invention relates to a method of characterizing biochips with matrix-assisted laser desorption/ionization and time of flight mass spectrometry (maldi-tof ms).. .
05/15/14
20140134236
Individualized cancer therapy
In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue from such patient; (c) extracting total protein and rna from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue using 2d dige and mass spectrometry; (e) identifying proteins that are expressed in such cancer tissue at significantly different levels than in the normal tissue; (f) obtaining a gene expression profile of the cancer tissue and normal tissue using microarray technology and comparing the results thereof to the protein expression profile; (g) prioritizing over-expressed proteins by assessing the connectivity thereof to other cancer-related or stimulatory proteins; (h) designing an appropriate rna interference expression cassette to, directly or indirectly, modulate the expression of genes encoding such prioritized proteins; (i) incorporating said cassette into an appropriate delivery vehicle; and (j) providing the patient with an effective amount of the delivery vehicle to, directly or indirectly, modify the expression (i.e., production) of such proteins.. .


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Mass Spectrometry topics: Mass Spectrometry, Spectrometry, Spectrometer, Mass Spectrometer, Chromatograph, Extrapolate, Hydrocarbon, High Resolution, Chromatography, Quantitative, Drug Resistance, Phosphorylation, Peptide Sequence, Formaldehyde, Amino Acid

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