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This page is updated frequently with new Mass Spectrometer-related patent applications. Subscribe to the Mass Spectrometer RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometer RSS RSS


Systems and methods for using interleaving window widths in tandem mass spectrometry

Dh Technologies Development Pte.

Systems and methods for using interleaving window widths in tandem mass spectrometry

Date/App# patent app List of recent Mass Spectrometer-related patents
05/21/15
20150142361
 High dynamic range detector correction algorithm patent thumbnailnew patent High dynamic range detector correction algorithm
Systems and methods are provided to perform dead time correction. An observed ion count rate is obtained using a non-paralyzable detection system of a mass spectrometer.
Dh Technologies Development Pte. Ltd.
05/21/15
20150136968
 Systems and methods for using interleaving window widths in tandem mass spectrometry patent thumbnailnew patent Systems and methods for using interleaving window widths in tandem mass spectrometry
Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.
05/14/15
20150129758
 Systems and methods for sequencing peptides by mass spectrometry patent thumbnailSystems and methods for sequencing peptides by mass spectrometry
The number of atoms present in an ion of a molecule is identified using a mixture of different forms of the molecule. A mass spectrometer analyzes a mixture of at least two forms of the molecule using one or more ion scans producing a mass spectrum.
05/14/15
20150129757
 Systems and methods for using variable mass selection window widths in tandem mass spectrometry patent thumbnailSystems and methods for using variable mass selection window widths in tandem mass spectrometry
Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
05/07/15
20150126403
 Method of identifying proteins in human serum indicative of pathologies of human lung tissues patent thumbnailMethod of identifying proteins in human serum indicative of pathologies of human lung tissues
A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known to have non-small cell lung cancers and asthma, as diagnosed by a physician. Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer.
Cancer Prevention And Cure, Ltd
05/07/15
20150123354
 Sealing surface, in particular for a vacuum chamber of a mass spectrometer and  manufacturing such a sealing surface patent thumbnailSealing surface, in particular for a vacuum chamber of a mass spectrometer and manufacturing such a sealing surface
A sealing surface, in particular for a vacuum chamber of a mass spectrometer and an associated manufacturing process, has non-circular shapes and can be produced with low effort. The sealing surface has circumferential cracks, being produced by erosion or jet machining or indentation-forming.
Vacutec Hochvakuum- & Präzisionstechnik Gmbh
05/07/15
20150123012
 Sample plate using maldi-tof mass spectrometer and manufacturing  the sample plate patent thumbnailSample plate using maldi-tof mass spectrometer and manufacturing the sample plate
A sample plate in use with a maldi-tof (matrix-assisted laser desorption ionization time-of-flight) mass spectrometer. The sample plate is usable for the mass spectrometry of a polymeric material on the order of several hundreds of da and a method of manufacturing the same sample plate.
Industry-academic Cooperation Foundation, Yonsei University
05/07/15
20150122991
 Sample transferring  mass cytometry patent thumbnailSample transferring mass cytometry
In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (icp) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion.
Fluidigm Canada Inc.
05/07/15
20150122986
 Mass spectrometer with laser spot pattern for maldi patent thumbnailMass spectrometer with laser spot pattern for maldi
The invention relates to mass spectrometers with an ion source, comprising a uv laser system for mass spectrometric analyses with ionization of analyte molecules in a sample by matrix-assisted laser desorption, which, with very low energy losses, can produce a spatially distributed spot pattern with several intensity peaks of equal height, thus making it possible to achieve an optimum degree of ionization of analyte ions for any task. Such a spot pattern can be generated from the uv beam with high transverse coherence, using a combination of a lens array and a lens, provided that the lens array satisfies a mathematical condition for separation of the micro-lenses from each other (pitch) and their focal length.
Bruker Daltonik Gmbh
05/07/15
20150121993
 Dispersive liquid-liquid microextraction  detecting n-nitrosoamines patent thumbnailDispersive liquid-liquid microextraction detecting n-nitrosoamines
The dispersive liquid-liquid microextraction (dllme) method of detecting n-nitrosoamines (nas) is a dllme performed with a xylene extraction solvent and a methanol disperser solvent. The microextraction is preferably performed by a programmable array logic (pal) auto-sampler.
King Fahd University Of Petroleum And Minerals
04/30/15
20150115151

Ion mobility spectrometer


A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the ims.
Leco Corporation
04/23/15
20150111787

Digital microfluidic chips for automated hydrogen deuterium exchange (hdx) ms analysis


Described herein is a digital microfluidic droplet generator (dmdg) and a microfluidic platform for processing material introduced into the dmdg. The combination is particularly suited for hydrogen/deuterium exchange and mass spectrometer (hdx-ms) processing and analysis of membrane proteins..
The Regents Of The University Of California
04/23/15
20150111300

Apparatus for pretreating biological samples, and mass spectrometer equipped with same


A clinical laboratory apparatus includes a pretreating apparatus having a high separation capability and providing high data reproducibility and reliability and a mass spectrometer is provided which executes fully automatic processing from pretreatment to detection. The pretreating apparatus that includes a cartridge for holding an extraction agent for solid-phase extraction, a pressure-loading unit for applying a pressure load to any cartridge mounted on the solid-phase extraction cartridge-retaining unit, a receiving tray mechanism for receiving a sample extracted from the cartridge, and a liquid-level sensor for detecting liquid levels in the receiving tray as well as in the cartridge, conducts feedback control for the pressure-loading unit to open its pressure release valve upon the liquid-level sensor detecting that the liquid level in the receiving tray mechanism has reached a preset liquid-level position..
Hitachi High-technologies Corporation
04/23/15
20150108348

Mass spectrometer


The larger an m/z to be adjusted, the wider a peak width which represents change in intensity in relation to change in voltage. This allows voltage step size to be increased during a search for an optimum voltage without overlooking a maximum intensity.
Shimadzu Corporation
04/23/15
20150108347

Method and apparatus to desolvate ions at high pressure and to improve transmission and contamination in the coupling of mass spectrometers and mobility spectrometers with ionizers


A method and apparatus that operate at near atmospheric pressure are described to simultaneously (i) desolvate the droplets produced by an ions source (including electrospray sources), to (ii) separate the surviving droplets from the analyte ions, to (iii) increase the transmission of ions through the inlet of an analyzer, while (iv) preventing the passage through said inlet of neutral contaminants and low mobility species and droplets that could potentially impair the operation of the analyzer, which include mass spectrometers and ion mobility spectrometers. In the present invention, contaminant low mobility species are efficiently deflected away from the analyzer inlet by a sweep flow.
Sociedad Europea De Analisis Diferencial De Movilidad
04/23/15
20150108342

Extraction and detection system and method


An apparatus, system and method for the continuous flow extraction, collection and analysis of small amounts of energetic substance/s and their reacted/unreacted residue/s in real time are provided. The apparatus includes an agitator that generates a particulate material from a surface.
04/23/15
20150108341

Mass spectrometer and mass spectrometry


A portable mass spectrometer that is carried to a sampling site to conduct analysis incorporates measures against erroneous operation. To prevent erroneous operation, when a measurement sample cannot be accurately analyzed because of contamination in the measurement sample, a criterion for aborting the sample measurement is provided and mass spectrometer control maintenance is performed.
Hitachi High-technologies Corporation
04/23/15
20150108340

Switch circuit, mass spectrometer, and control switch circuit


Provided is a switch circuit that includes plural mos switches connected in series in such a manner that the source of one element is connected to the drain of another between high voltage and a system ground and that switches a connection state between the high voltage and the system ground, the switch circuit including: a mos switch 101 the source of which is connected to the system ground among the plural mos switches; a mos switch 102 the source of which is connected to the drain of the mos switch 101 in a shared manner and the drain of which is connected to the high voltage side among the plural mos switches; a mos switch 103 the drain of which is connected to the gate of the mos switch 102 in a shared manner; and a resistor 104 that is connected in parallel between the gate and the source of the mos switch 102.. .
04/23/15
20150107349

Mud logging depth and composition measurements


A sample that includes formation content from a subsurface formation and other sample constituents is obtained while the sample is in close proximity to the subsurface formation. While downhole, the formation content is separated from the other sample constituents by passing the sample through an oil-wet porous plate, a water-wet porous plate, or through both plates, and analyzed.
Schlumberger Technology Corporation
04/23/15
20150107331

Integrated hydrocarbon analysis


Petroleum or other hydrocarbon samples can be analyzed in parallel by 1) gc-field ionization time of flight mass spectrometer (gc-fi-tof ms) and 2) two dimensional gas chromatography (2d-gc) equipped with a flame ionization detector (fid). The combined techniques allow for improved quantitative characterization of the compounds within a hydrocarbon sample.
Exxonmobil Research And Engineering Company
04/16/15
20150102219

Tandem quadrupole mass spectrometer


Prior to multiple reaction monitoring (mrm) measurement condition optimization, an analysis operator prepares, for each precursor ion of an objective compound, two lists on a product-ion selection condition setting screen 200, i.e. A list 203 which shows ions to be preferentially selected as product ions for which the optimization needs to be performed and a list 202 which shows ions to be excluded from the optimization.
Shimadzu Corporation
04/16/15
20150102217

Introduction of ions into ion cyclotron resonance cells


The invention relates to a method and a device for introducing ions into an icr cell of fourier transform ion cyclotron resonance mass spectrometers, in particular with a reduced the magnetron orbit. The invention is based on applying at least one gated dc voltage to a mantle electrode of the icr cell prior to the excitation of the cyclotron motion such that injected ions are deflected inside the icr cell in at least one radial direction..
Bruker Daltonik Gmbh
04/16/15
20150102215

Collision cell multipole


mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion.
Thermo Fisher Scientific (bremen) Gmbh
04/16/15
20150102213

Electrode device with pre- and/or postfilters and manufacturing method therefor, as well as a mass spectrometer with such an electrode device


A method manufactures a multipolar electrode device, in particular a multipole for use in a mass spectrometer, wherein the electrode device includes at least one main filter and at least one pre- and/or postfilter. The electrode blanks are separated in several sections for producing the pre- and/or postfilters, which are thereby maintained by a holder in a constant relative position to each other.
Vacutec Hochvakuum- & PrÄzisionstechnik Gmbh
04/09/15
20150097115

Method and a combined linear ion trap and quadrupole mass filter


An apparatus for a mass spectrometer comprises: a set of four rod electrodes defining an ion occupation volume therebetween having entrance and exit ends, at least one of the rod electrodes having a slot passing therethrough; first and second ion optics disposed adjacent to the entrance and exit ends, respectively; a voltage supply system; and at least one supplemental electrode disposed at least partially within the at least one slot, wherein the voltage supply system is configured so as to supply a radio-frequency (rf) voltage, a direct-current (dc) filtering voltage and an oscillatory dipole resonant ejection voltage across members of the set of rod electrodes and so at to supply a secondary ion-trapping rf voltage and a secondary dc filtering voltage to the at least one supplemental electrode and to supply dc voltages across the rod electrodes and each of the first and second ion optics.. .
Thermo Finnigan Llc
04/09/15
20150097114

Excitation of reagent molecules withn a rf confined ion guide or ion trap to perform ion molecule, ion radical or ion-ion interaction experiments


A mass spectrometer is disclosed comprising an rf ion guide or ion trap and a device arranged and adapted to supply a reagent gas within the rf ion guide or ion trap. The mass spectrometer further comprises a photo-ionisation device and a control system arranged and adapted: (i) to cause first ions to fragment or dissociate within the rf ion guide or ion trap to form second ions and neutral molecules; and (ii) to cause the photo-ionisation device to photo-ionise and/or photo-excite the reagent gas to form reagent ions, excited species or radical species.
Micromass Uk Limited
04/09/15
20150097113

Modulation of instrument resolution dependant upon the complexity of a previous scan


Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor.
Dh Technologies Development Pte. Ltd.
04/02/15
20150090874

Method and apparatus to provide parallel acquisition of mass spectrometry/mass spectrometry data


A system and method for acquisition of mass spectrometry data is configured to provide a stream of charged particles (e.g., from an analytical volume). A primary mass spectrometer (e.g., time-of-flight mass spectrometer) may be used to separate charged particles of the stream of charged particles based on their mass-to-charge ratio and detect the charged particles in a mass-to-charge spectrum.
Ulvac-phi, Incorporated
04/02/15
20150090872

Mass spectrometer


A hardware module which operatively carries out a method of compressing mass spectral data, the method comprising: receiving a first signal output from an ion detector of a mass spectrometer; processing the first signal to a digital signal at an output being data frame types representative of the first signal output; temporarily storing the data frame types in a memory block and reading a data frame from the memory block and determining its data frame type and according to its data frame type compressing the data frame according to one or more compression algorithms to generate a compressed data output stream.. .
Micromass Uk Limited
03/19/15
20150080233

Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry


A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (sims) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set.
The Board Of Trustees Of The Leland Stanford Junior University
03/19/15
20150076366

Mass spectrometric ion storage device for different mass ranges


The invention relates to devices and methods for the storage of ions in mass spectrometers. The invention proposes the generation and superposition of two multipole fields of different order, independent of each other, in an rf multipole rod system.
Bruker Daltonik Gmbh
03/19/15
20150076341

Method of mass spectrometry and a mass spectrometer


The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas..
Micromass Uk Limited
03/19/15
20150076338

Mass spectrometer, control system and methods of operating and assembling a mass spectrometer


A mass spectrometer and methods for controlling a mass spectrometer are provided. In an exemplary embodiment, the mass spectrometer includes a plurality of discrete functional modules, each operable to perform a predetermined function of the mass spectrometer, wherein the modules are individually addressable and connected in a network.
Micromass Uk Limited
03/12/15
20150068279

Electro-enhanced solid-phase microextraction method


The electro-enhanced solid-phase microextraction (ee-spme) method involves extraction that is performed with an spme fiber, preferably made of polydimethylsiloxane (pdms), in the presence of an applied electric potential for a predetermined period of time. Polar analytes are extracted onto the fiber, which is the stationary phase.
King Fahd University Of Petroleum And Minerals
03/05/15
20150066421

Method for following degassing rate by measuring partial pressures measured bymass spectrometry


Where m denotes the set of reference atomic masses, pi denotes the partial pressures for the atomic masses measured by the mass spectrometer, the coefficients αi denote preset weighting coefficients associated with each partial pressure pi, and n denotes a maximum atomic mass for which the partial pressure pi can be measured by the mass spectrometer.. .
03/05/15
20150066387

Substance identification method and mass spectrometer using the same


Ms1 and ms2 measurements of fractionated samples are performed. Based on the identification results and the s/n ratios of the ms1 peaks, an identification probability estimation model showing a relationship between the cumulative number of ms1 peaks and the number of ms1 peaks successfully identified through the ms2 measurements and identifications performed in ascending order of s/n ratio is created.
Shimadzu Corporation
03/05/15
20150064793

Method of discerning substitution of carbohydrate esters


A method of testing for discerning substitution of carbohydrate ester includes the step of providing a predetermined amount of a solution. Further, the method also includes adding ammonium hydroxide and sodium borohydride to the solution.
Biologistics Llc
03/05/15
20150064739

Analyzer


An analyzer includes a pretreatment device and a mass spectrometer. The pretreatment device includes a solid phase extraction mechanism.
Hitachi High-technologies Corporation
03/05/15
20150060687

Ion deflector for a mass spectrometer


There is provided an ion deflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The ion deflector includes an electric field inducer arranged so as to establish at least one electrostatic field capable of deflecting ions travelling substantially along a first intended path of travel so as to travel substantially along a second intended path of travel..
Bruker Chemical Analysis Bv
02/26/15
20150053854

Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum


Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry..
Wayne State University
02/26/15
20150053853

Plume collimation for laser ablation electrospray ionization mass spectrometry


In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume.
The George Washington University
02/19/15
20150048255

Ion source for mass spectrometer and producing analyte ion stream


An ion source for a mass spectrometer and a method of ionizing a sample are disclosed. A droplet generator is configured to emit a stream of analyte droplets, which are ionized upon impact with a target, thus forming an ion stream.
Waters Technologies Corporation (a Delaware Corp)
02/19/15
20150048245

Ion optical system for maldi-tof mass spectrometer


An ion accelerator for a time-of-flight mass spectrometer includes a pulsed ion accelerator positioned proximate to a sample plate and having an electrode that is electrically connected to the sample plate. An accelerator power supply generates an accelerating potential on the ion accelerator electrode that accelerates a pulse of ions generated from the sample positioned on the sample plate.
Virgin Instruments Corporation
02/12/15
20150041641

Mass spectrometer


A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample.
Hitachi High-technologies Corporation
02/05/15
20150039233

Method for near real time surface logging of a hydrocarbon or geothermal well using a mass spectrometer


An automatic method for providing geological trends and real time mapping of a geological basin using a mass spectrometer. The method provides information from a mass spectrometer on fluid samples from a wellbore into a geochemical surface well log with graphical tracks in real time.
Selman And Associated, Ltd
02/05/15
20150037606

Electrolytic copper foil, cleaning fluid composition and cleaning copper foil


An electrolytic copper foil includes a copper foil body; and a iia-group metal adhered to a surface of the copper foil body, wherein a signal strength of the iia group metal is greater than 0.1% based on a signal strength of copper element as 100% analyzed by a secondary ion mass spectrometer. The present invention also provides a method for cleaning copper foil and a cleaning fluid composition which is used in the cleaning method..
Chang Chun Petrochemical Co., Ltd.
02/05/15
20150034821

Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system


Provided is an ionization apparatus including: a holder configured to hold a sample; a probe configured to determine a part to be ionized of the sample held by the holder; an extract electrode configured to extract ionized ions of the sample; a liquid supply unit configured to supply liquid to a part of a region of the sample; and a unit configured to apply a first voltage between the probe and the extract electrode, in which the first voltage is pulse-modulated.. .
Canon Kabushiki Kaisha
02/05/15
20150034820

Continuous operation high speed ion trap mass spectrometer


The present disclosure discusses a system and method for continuous operation of an ion trap mass spectrometer. The described system does not introduce ions into the ion trap in distinct trapping phase, rather the described system continuously injects ions into the ion trap while continuously scanning out the ions.
Mini-mass Counseling
02/05/15
20150034819

Multiple channel detection for time of flight mass spectrometer


An ion detector for a time of flight mass spectrometer is disclosed comprising a single microchannel plate which is arranged to receive ions and output electrons. The electrons are directed onto an array of photodiodes which directly detects the electrons.
Micromass Uk Limited
02/05/15
20150034818

Discontinuous atmospheric pressure interface


A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample.
Purdue Research Foundation
02/05/15
20150034816

Interface for mass spectrometry apparatus


There is provided an interface for use in sampling ions in a mass spectrometer, the interface being arranged for receiving a quantity of ions from an ion source and forming more than one ion beam therefrom, each ion beam being directed along a respective desired pathway.. .
Bruker Chemical Analysis Bv
02/05/15
20150034814

Maldi imaging and ion source


An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm.
Micromass Uk Limited
02/05/15
20150034813

Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis


A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as hydrogen-deuterium exchange.
Micromass Uk Limited
02/05/15
20150034812

Multi-dimensional chromatograph system


In a two-dimensional lc system configured to introduce components trapped in a trap column during a fractionation period t into a second-dimension column, separate components, and then detect the components using a mass spectrometer, a data collection unit receives a signal which indicates timing to delimit the fractionation period t, determines the first data item in the fractionation period t, adds measurement start point identification information to the first data item, and stores all the data in a data storage unit. A two-dimensional chromatogram creation unit recognizes the first data item in each fractionation period t from the read data, and create a two-dimensional chromatogram by aligning data so that the first data items will be aligned at the top along an abscissa..
Shimadzu Corporation
01/29/15
20150028743

Device for supplying voltage to the cathode of a mass spectrometer


A simplified device for voltage supply of the cathode of a mass spectrometer comprises a push-pull transformer, wherein, apart from the normal rectifier diodes (7, 9), a controlled rectifier (8, 10) is provided. The gate of the first transistor (8) is connected to the second output (30), and the gate of the second transistor (10) is connected to the first output (32) of the transformer.
Inficon Gmbh
01/29/15
20150028221

Methods of ion source fabrication


A method of ion source fabrication for a mass spectrometer includes simultaneously forming aligned component portions of an ion source using direct metal laser fusing of sequential layers. The method can further include forming the component portions on a base plate made from a ceramic material by applying fused powder to the base plate to build the component portions thereon..
Hamilton Sundstrand Corporation
01/29/15
20150028198

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction and having a space therebetween, the x direction being orthogonal to y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the x direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length..
Thermo Fisher Scientific (bremen) Gmbh
01/29/15
20150028197

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction, the x direction being orthogonal to y, characterized in that the mirrors are not a constant distance from each other in the x direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer.
Thermo Fisher Scientific (bremen) Gmbh
01/22/15
20150025813

Systems and methods for sequential windowed acquisition across a mass range using an ion trap


Systems and methods are provided to perform sequential windowed acquisition of mass spectrometry data. A mass range and a mass window width parameter are received for a sample.
Dh Technologies Development Pte. Ltd.
01/22/15
20150024510

Performing chemical reactions and/or ionization during gas chromatography-mass spectrometry runs


A gas chromatography-mass spectrometry (gc-ms) method that includes performing a first gc-ms run on a sample using a gas chromatography-mass spectrometry system. Performing the first gc-ms nm includes i) passing a first flow of a carrier gas carrying a first portion of the sample through a gas chromatograph to provide a first effluent; ii) generating first ions under protonation conditions by passing the first effluent through an atmospheric pressure ionization source; iii) passing the first ions through a mass spectrometer; and iv) recording first gc-ms data for the first ions.
Waters Technologies Corporation
01/22/15
20150021471

Electrostatic mass spectrometer with encoded frequent pulses


A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
Leco Corporation
01/22/15
20150021469

Interfacing capillary electrophoresis to a mass spectrometer via an impactor spray ionization source


A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a capillary electrophoresis (“ce”) separation device.
Micromass Uk Limited
01/22/15
20150021467

Segmented planar calibration for correction of errors in time of flight mass spectrometers


An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions.
Micromass Uk Limited
01/15/15
20150014523

Method for determining the maximum mass peak in mass spectrometry


A fast method for determining molecular mass using mass spectrometry has the following steps: specifying a first adjusting value (m1) of the mass spectrometer, recording the associated signal amplitude (a1), specifying a second adjusting value (m2) which is different to the first, measuring the associated second signal amplitude (a2), specifying a third adjusting value (m3) which is different to the first (m1) and the second (m2) adjusting value, measuring the associated third signal amplitude (a3), determining a quadratic function containing the measured amplitude values as y-values and the specified adjusting values as x-values, determining the maximum of the quadratic function, wherein the searched adjusting value is determined from the x-value of the maximum.. .
Inficon Gmbh
01/15/15
20150014522

First and second order focusing using field free regions in time-of-flight


In some embodiments, a time of flight mass spectrometer can comprise an input orifice for receiving ions, a first ion accelerator stage for accelerating the ions along a first path, at least one ion reflector for receiving said accelerated ions and redirecting said ions along a second path different than the first path, a detector for detecting at least a portion of the ions redirected by said at least one ion reflector, and at least first and second field free drift regions disposed between said first acceleration stage and said detector, wherein said second field free region is disposed in proximity of the detector. In some embodiments, the lengths of the field free drift regions can be selected so as to provide 1st and 2nd order corrections of the time of flight of the ions with respect to variation in their initial positions..
Dh Technologies Development Pte. Ltd.
01/15/15
20150013438

Analytical detecting sulfated oligosaccharides


The present invention describes an analytical method for detecting and quantitating poly-sulfated oligosaccharides, including fondaparinux sodium, using hydrophilic interaction ultra-performance liquid chromatography (hilic-uplc) coupled with a charged aerosol detector (cad) or a mass spectrometer (ms). This analytical method provides in-process control in a total synthesis of highly sulfated oligosaccharides by separation, quantification and mass identification.
Scinopharm Taiwan, Ltd.
01/08/15
20150012219

System for near real time surface logging of a geothermal well, a hydrocarbon well, or a testing well using a mass spectrometer


A system for providing geological trends and real time mapping of a geological basin. The system provides in real time, information from a mass spectrometer on fluid samples from a wellbore, and forms a geochemical surface well log with graphical tracks.
Selman And Associates, Ltd.
01/08/15
20150012218

Method for near real time surface logging of a geothermal well, a hydrocarbon well, or a testing well using a mass spectrometer


A method for providing geological trends and real time mapping of a geological basin by forming a geochemical surface well log. The method provides in real time, information from a mass spectrometer on fluid samples from a wellbore, into a geochemical well log template using computer instructions to create a plurality of graphical tracks.
Selman And Associates, Ltd.
01/08/15
20150008320

Method and improved sensitiivity in a mass spectrometer


An ion source and an ion guide chamber are provided. The ion guide chamber having a gas flow, the gas flow having a longitudinal velocity and a transverse velocity.
Dh Technologies Development Pte. Ltd.
01/08/15
20150008317

System and quantitation in mass spectrometry


A method of operating a tandem mass spectrometer system is disclosed including accumulating ions in an ion trap, transmitting a plurality of ions out of the ion trap into a timed-ion selector, applying a pulsed dc voltage to the timed-ion selector, the pulsed dc voltage being modulated to match an ejection time for selecting a first portion of ions from the plurality of ions, corresponding to a specific m/z window, transmitting the first portion of selected ions out of the timed-ion selector into a reaction cell, transmitting dissociation product ions and the remaining ions of the first portion of selected ions out of the reaction cell into a mass analyzer, and mass-selectively transmitting at least some of the fragment ions and the remaining ions of the first portion of selected ions out of the mass analyzer into a detector.. .
Dh Technologies Development Pte. Ltd.
01/08/15
20150008312

Generation of reagent ions for ion-ion reactions


An apparatus, system and method of providing that allow for the generation of reagent ions within an inner region of a mass spectrometer for use in ion-ion reactions such as ptrs and etd using a reagent ion generator. The location where these reagent ions are generated can be as close as possible to the point of action, or the reaction zone where the reagent ion and analyte ions will interact via ion-ion reactions to cause, e.g., ptrs and/or etd..
Dh Technologies Development Pte. Ltd.
01/08/15
20150008311

Reduction of cross-talk between rf components in a mass spectrometer


The invention generally relates to an assembly of a first rf component and a second rf component in a mass spectrometer, the first rf component comprising a first set of electrodes and the second rf component comprising a second set of electrodes, wherein the rf components are located and aligned end-to-end to one another, and wherein a transverse dimension of the electrodes of the first set is smaller than that of the electrodes of the second set. The assembly further comprises a conductive electric field screen located at an outer periphery of the first set of electrodes and facing the electrodes of the second set as to reduce rf electric field cross-talk between the electrodes of the first set and those of the second set.
Bruker Daltonics, Inc.
01/08/15
20150008310

Pulsed mass calibration in time-of-flight mass spectrometry


A method is provided for calibrating mass-to-charge ratio measurements obtained from a time-of-flight mass spectrometer used as a detector for a chromatographic system. The method can include introducing a calibrant material into the time-of-flight mass spectrometer after a sample is introduced to the chromatographic system, but before the analysis of the sample is complete, such that calibrant material and sample material are not present at the ion source of the mass spectrometer, contemporaneously, and back-flushing residual or leaking calibrant through a back-flush line and away from the mass spectrometer..
Zoex Corporation


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Mass Spectrometer topics: Mass Spectrometer, Spectrometer, Mass Spectrometry, Spectrometry, Downstream, Coordinates, Quantitative, Chromatograph, Data Processing, Biomolecule, Data Acquisition, Electrical Signal, Data Compression, Fragmentation, Irradiation

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