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Mass Spectrometer patents

      

This page is updated frequently with new Mass Spectrometer-related patent applications.




Date/App# patent app List of recent Mass Spectrometer-related patents
08/18/16
20160240364 
 Mass spectrometer patent thumbnailMass spectrometer
A mass spectrometer includes: an ionization unit configured to ionize an analyte gas; a filter unit configured to allow passage of only a target ion which is a component of the analyte gas ionized in the ionization unit and which has a specific mass-to-charge ratio; and an ion detection unit configured to detect an ion detection value based on the target ion having passed through the filter unit, wherein the ion detection unit includes a faraday electrode which includes an electrode portion disposed along a centerline of the filter unit and a bottom electrode provided at a position downstream of the electrode portion in a flow of the target ion, the electrode portion and the bottom electrode being connected to each other, a secondary electron multiplier provided to face the electrode portion with the centerline located therebetween, and a blocking portion connected to the bottom electrode.. .
Canon Anelva Corporation


08/18/16
20160240363 
 Open trap mass spectrometer patent thumbnailOpen trap mass spectrometer
An open electrostatic trap mass spectrometer is disclosed for operation with wide and diverging ion packets. Signal on detector is composed of signals corresponding to multiplicity of ion cycles, called multiplets.
Leco Corporation


08/18/16
20160240360 
 Flow through ms3 for improved selectivity patent thumbnailFlow through ms3 for improved selectivity
Systems and methods are provided for selecting and fragmenting a first precursor ion in an ms3 experiment. One or more first excitation parameters are calculated that define a first dipole excitation using a processor.
Dh Technologies Development Pte. Ltd.


08/18/16
20160240358 
 Chromatograph mass spectrometer patent thumbnailChromatograph mass spectrometer
A chromatograph mass spectrometer including an optimum gas pressure search controller that performs an mrm measurement for a target compound while changing a collision-gas pressure, investigates an optimum collision-gas pressure giving a highest signal strength based on the measured result, and stores the same gas pressure for each compound in a compound-related information storage section. When a target compound is specified in a simultaneous multicomponent analysis, a control sequence determiner reads the optimum collision-gas pressure and retention time information corresponding to the specified compound from the storage section, prepares a control sequence which sets the gas pressure in a collision cell at the optimum gas pressure at the timing where each compound is eluted, and stores the sequence in a control sequence storage section..
Shimadzu Corporation


08/11/16
20160233078 
 Method and  mass analysis utilizing ion charge feedback patent thumbnailMethod and mass analysis utilizing ion charge feedback
A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyser; the batch of ions accumulated in the mass analyser is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyser is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyser; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyser.. .
Thermo Fisher Scientific (bremen) Gmbh


08/11/16
20160233076 
 Multireflection time-of-flight mass spectrometer patent thumbnailMultireflection time-of-flight mass spectrometer
A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location.
Thermo Fisher Scientific (bremen) Gmbh


08/11/16
20160233075 
 Mass spectrometers comprising accelerator devices patent thumbnailMass spectrometers comprising accelerator devices
A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
Micromass Uk Limited


08/11/16
20160233074 
 Interface for ion source and vacuum housing patent thumbnailInterface for ion source and vacuum housing
A mass spectrometer or ion mobility spectrometer is disclosed comprising: an ion block (2) for receiving ions; a heater (8) for heating the ion block (2); a vacuum housing (6); and an interface block (4) arranged between the ion block (2) and the vacuum housing (6); wherein the interface block (4) is formed from a polymer. The polymer interface block (4) inhibits the heat transfer from the ion block (2) to the vacuum housing (6) and also electrically isolates the ion block (2) and vacuum housing (6).
Micromass Uk Limited


08/11/16
20160233073 
 Automated cleanliness diagnostic for mass spectrometer patent thumbnailAutomated cleanliness diagnostic for mass spectrometer
A mass spectrometer or ion mobility spectrometer is disclosed comprising means for detecting a blockage in an inlet orifice arranged between an ion source and a vacuum chamber. The blockage is detected as a result of a reduction in pressure within the vacuum chamber.
Micromass Uk Limited


08/11/16
20160233072 
 Gasket seal for a mass spectrometer patent thumbnailGasket seal for a mass spectrometer
A gasket seal for a mass spectrometer is disclosed. The gasket seal comprises a membrane having an outer profile and an inner profile and one or more protrusions.
Micromass Uk Limited


08/11/16
20160233070 

Ion inlet assembly


An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body having a sampling orifice. The sampling limiting body comprises a nickel disk wherein the disk and sampling orifice are made or formed by an electroforming process..
Micromass Uk Limited


08/11/16
20160233069 

Gas diffuser ion inlet


In some embodiments, a gas diffuser for use in a mass spectrometer is disclosed that can provide a controlled expansion of an ion-containing gas so as to reduce gas velocity for entry into subsequent stages of the mass spectrometer, e.g., a mass analyzer. In some embodiments, the controlled expansion of the gas is provided by flowing the gas through a channel whose cross-sectional area change, e.g.
Dh Technologies Development Pte.ltd.


08/11/16
20160233067 

Mass spectrometer


Apparatus for a mass spectrometer is disclosed comprising an ion source, a heater for heating a gas flow to the ion source, a temperature sensor for monitoring the temperature of the heater, and a control system. The control system is arranged and adapted to determine a flow rate of the gas flow by monitoring the power supplied to the heater and the temperature of the heater..
Micromass Uk Limited


08/11/16
20160233066 

Ion transfer


An ion transport device can include a plurality of pole rod pairs arranged in parallel, and a controller. The controller configured to can be configured to apply voltages in a repeating voltage pattern of to the pole rod pairs thereby creating a plurality of potential wells capable of capturing ions, and move the repeating voltage pattern along the pole rod pairs to move captured ions along the ion transport device.
Thermo Finnigan Llc


08/11/16
20160233065 

Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


08/11/16
20160233064 

Parsing events during ms3 experiments


Systems and methods are provided for reducing the time period of a cid event of an ms3 experiment and making the overall fragmentation event more generic. A cid event of an ms3 experiment performed on a sample by a mass spectrometer is divided into two time periods using a processor.
Dh Technologies Development Pte. Ltd.


08/11/16
20160231341 

Multidrug analysis in urine by liquid chromatography-tandem mass spectrometry


A fast and reliable method for the determination of multiple drugs and their metabolites belonging to different chemical and toxicological class from a biological sample is provided. The method involves mixing of biological sample with internal standards which does not require sample extraction or derivatization prior to analysis.
Castle Medical, Llc


08/11/16
20160231295 

Use of windowed mass spectrometry data for retention time determination or confirmation


A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans.
Dh Technologies Development Pte. Ltd.


08/11/16
20160230889 

Chamber seal for mass spectrometer


A mass spectrometer is disclosed comprising a first component, an annular vacuum chamber seal and a second component. The first component has a groove.
Micromass Uk Limited


08/04/16
20160225602 

Time-of-flight mass spectrometry using multi-channel detectors


A time-of-flight mass spectrometer (tof-ms) utilizes a multi-channel ion detector to detect ions traveling in separate flight paths, spatially dispersed along a drift axis and/or a transverse axis, in a flight tube of a tof analyzer. The ion beams may be dispersed by drift energy, deflection along the drift and/or transverse axis, ion mass, or a combination of two or more of the foregoing.
Agilent Technologies,inc.


08/04/16
20160225601 

Miniature ion source of fixed geometry


A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μl/min.
Micromass Uk Limited


08/04/16
20160225598 

Pulsed ion guides for mass spectrometers and related methods


An ion guide generates a radio frequency (rf) field to radially confine ions to an ion beam along a guide axis as the ions are transmitted through the ion guide. The effective potential of the rf field includes an alternating series of barriers and wells.
Agilent Technologies, Inc.


08/04/16
20160225596 

Method and transporting samples in a mass spectrometer


A sample plate handling system for a time-of-flight mass spectrometer includes a transport chamber and a mass spectrometer chamber that is mechanically coupled to transport chamber. A vacuum chamber is coupled through a bypass valve to the transport chamber.
Virgin Instruments Corporation


08/04/16
20160225594 

Data independent acquisition of product ion spectra and reference spectra library matching


Systems and methods are disclosed for detecting compounds in a sample using a tandem mass spectrometer. A sample comprising a plurality of detectable compounds that have been separated in time over a time interval is introduced into a tandem mass spectrometer.
Eth Zürich


08/04/16
20160225593 

Rf-only detection scheme and simultaneous detection of multiple ions


A mass spectrometer apparatus and method for conducting simultaneous ms/ms analysis including: a device to select a precursor ion having a specified m/z; a gas-filled collision cell; an rf-only multipole mass spectrometer, the mass spectrometer having a generator attached thereto for generating at least two auxiliary ac fields in the rf-only multipole mass spectrometer; a gate for providing a repulsive dc or ac barrier downstream to an exit of the rf-only multipole mass spectrometer; an ion detection system situated downstream from the dc or ac barrier for measuring an ion current derived from ions that overcome the repulsive barrier. The mass spectrometer may also be configured so that each of the auxiliary ac fields are generated by the introduction of individual auxiliary ac frequencies and each frequency is amplitude modulated at a unique frequency..
Dh Technologies Development Pte. Ltd.


08/04/16
20160225592 

Fragment ion mass spectra measured with tandem time-of-flight mass spectrometers


The present invention provides a method for acquiring fragment ion mass spectra with a time-of-flight mass spectrometer, whereby mixed mass spectra with fragment ions of different parent ion species are acquired and compared with each other in such a way that the signals of those fragment ions which originate from the same parent ion species are determined. The time-of-flight mass spectrometer contains an ion source, a flight path, a reflector and an ion detector.
Bruker Daltonik Gmbh


08/04/16
20160223500 

Gas chromatograph-mass spectrometer


A column protection gas supply channel (4) is connected to a channel (17) for carrier gas present between a sample vaporization chamber (12) and an ms section (2). During a standby, a column (11) may be protected on the downstream side of a merging section (16) of the column protection gas supply channel (4) and the channel (17) for carrier gas by supplying column protection gas through the column protection gas supply channel (4).
Shimadzu Corporation


08/04/16
20160223424 

Sniffer leak detector with multi-stage membrane pump


A sniffer leak detector includes a mass spectrometer for analyzing hydrogen or helium, a turbomolecular pump which is connected with said mass spectrometer and whose outlet is connected with a prevacuum pump, and a sniffer probe which includes a plurality of intake lines and is connected with said inlet of said turbomolecular pump, wherein a vacuum pump includes at least three stages whose inlet stage defines said prevacuum pump and is connected with said outlet of said turbomolecular pump via a blocked throttle, wherein, between adjacent stages of said vacuum pump, an intermediate inlet each is provided, wherein each intermediate inlet is connected with a different intake line of said sniffer probe and at least one of the intake lines as a suction line is connected with said inlet of said turbomolecular pump for obtaining different gas flows.. .
Inficon Gmbh


07/28/16
20160217995 

Time-of-flight mass spectrometer


An embodiment of the invention relates to a tof-ms capable of performing mass spectrometry of a sample at a high throughput. The tof-ms has an acceleration part for accelerating an ion, a detector for detecting an event of arrival of the accelerated ion, and a data processing part for performing mass spectrometry of the sample, based on a time of flight of the ion.
Hamamatsu Photonics K.k.


07/28/16
20160217992 

Probe assembly for attaching a chromatography device to a mass spectrometer


A probe assembly is disclosed comprising an inlet for receiving an eluent from a chromatography device; an outlet (120) for delivering the eluent to an ion source of a mass spectrometer; and an attachment device (122) for attaching the outlet to the mass spectrometer. The outlet comprises an electrically conductive capillary (124) and an electrically conductive member (129) surrounding at least part of the electrically conductive capillary (124).
Micromass Uk Limited


07/28/16
20160217990 

System for recording spatial and temporal properties of ions emitted from a quadrupole mass filter


An ion detection system for a detecting a quantity of ions exiting from a mass analyzer of a mass spectrometer comprises: (a) photon generating means configured to receive the quantity of ions and to generate a quantity of photons that is proportional to the quantity of ions; (b) a linear array of photo-detectors configured along a line for detecting a variation of a portion of the quantity of generated photons along the line; and (c) an optical system for directing the portion of the quantity of photons from the photon generating means to the linear array of photo-detectors comprising: (c1) a first cylindrical lens having a first lens axis disposed parallel to the line; (c2) a second cylindrical lens or rod lens having a second lens axis disposed parallel to the line; and a doublet lens.. .
Thermo Finnigan Llc


07/28/16
20160217987 

Multiplexed precursor isolation for mass spectrometry


Systems and methods for identifying precursor ions of product ions from combined product ion spectra are provided. N precursor ions are selected.
Dh Technologies Development Pte. Ltd.


07/28/16
20160217986 

Peak assessment for mass spectrometers


A method of assessing mass spectral peaks obtained by a mass spectrometer is disclosed. The method comprises: providing experimentally obtained mass spectral data; selecting a chemical compound thought to have been analysed so as to provide said experimentally observed data, and modelling the spectral data predicted to be detected if the compound was to be mass analysed.
Micromass Uk Limited


07/28/16
20160217985 

Targeted mass analysis


A mass spectrometer comprises: an ion source that generates ions having an initial range of mass-to-charge ratios; an auxiliary ion detector, downstream from the ion source that receives a plurality of first ion samples derived from the ions generated by the ion source and determines a respective ion current measurement for each of the plurality of first ion samples; a mass analyser, downstream from the ion source that receives a second ion sample derived from the ions generated by the ion source and to generate mass spectral data by mass analysis of the second ion sample; and an output stage that establishes an abundance measurement associated with at least some of the ions generated by the ion source based on the ion current measurements determined by the auxiliary ion detector.. .
Thermo Fisher Scientific (bremen) Gmbh


07/21/16
20160211129 

Mass spectrometer electrode


A monolithic electrode includes a first portion devoid of apertures and a second portion surrounded by the first portion, the second portion having a web defining a plurality of apertures. A method for forming an electrode includes forming a first electrode portion devoid of apertures and forming a second electrode portion having a web defining a plurality of apertures.
Hamilton Sundstrand Corporation


07/21/16
20160211125 

Method of calibrating mass-to-charge ratio measurements obtained from a mass spectrometer connected in fluid communication with an analysis system delivering a temporally changing sample


A method of calibrating mass-to-charge ratio measurements obtained from a mass spectrometer connected in fluid communication with a chromatographic system comprises the steps of acquiring a multiplicity of mass spectra of an analyte during an analytical run, analyzing at least some of the multiplicity of mass spectra during the analytical run for generating result data relating to a decision on introduction of a calibrant material into the mass spectrometer; and introducing the calibrant material into the mass spectrometer during the analytical run, based on the result data. An arrangement for mass analysis that is suitable for carrying out the method comprises a chromatographic system (10), a mass spectrometer (20) connected downstream, in fluid communication to the chromatographic system (10), a data acquisition device (22) for acquiring mass spectra of an analyte fed to the mass spectrometer (20), a controllable injector (30, 31) to introduce calibrant material into the mass spectrometer, and a control unit (50) receiving information on the acquired mass spectra from the data acquisition device (22), the control unit (50) configured to dynamically control the injector (30, 31) based on the received information..
Tofwerk Ag


07/21/16
20160209378 

Chromatograph mass spectrometer


When setting analysis conditions, an analysis operator sets, on a dwell-time calculation/loop-time listing window, the target value of a loop time corresponding to the measurement-time interval to repeat an analysis for one ion, and clicks a dwell time calculation button. Then, a dwell time calculator computes the dwell time for each event, based on the target value of the loop time, the arrangement of events set at that point in time, the number of target ion species set in each event, and other conditional factors.
Shimadzu Corporation


07/21/16
20160209362 

Gas analyzer with fuel cell


The invention relates to gas analyzers, especially mobile ion mobility spectrometers or mass spectrometers which are operated at atmospheric pressure to detect dangerous substances. The invention uses a fuel cell to generate the electric operating power of the gas analyzer, and the waste heat from the fuel cell is used to regulate the temperature of modules of the gas analyzer..
Bruker Daltonik Gmbh


07/14/16
20160203966 

Remote laser ablation electrospray ionization mass spectrometry


In various embodiments, a device may generally comprise a remote ablation chamber comprising an inlet and an outlet, a laser to deposit energy into a sample in the chamber to ablate the sample and generate ablation products in the chamber, a transport device in fluid communication with the outlet, an ionization source to ionize the ablation products to produce ions, and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation products or the ions may be transported in a fluid stream from the ablation chamber through the transport device.
The George Washington University


07/14/16
20160203964 

Mass spectrometer


The present disclosure provides a mass spectrometer for performing an analysis of sample ions, and a method for operating a mass spectrometer. The mass spectrometer comprises a first ion optical element that is supplied with a first gas; a mass analyzer, wherein the performance of the mass analyzer is dependent on the pressure of the first gas in the first ion optical element; and a controller for setting a property of the first gas, which comprises at least the pressure of the first gas, on the basis of a characteristic of the analysis to be performed by the mass spectrometer..
Thermo Fisher Scientific (bremen) Gmbh


07/07/16
20160196965 

Hybrid ion source and mass spectrometric device


In order to provide an ion source that can be easily switched with high sensitivity and in a short time, the ion source includes an ionization probe for spraying a sample, a heating chamber for heating and vaporizing a sample; and driving portions and for changing the distance between an outlet end (i.e., an end on the spray side) of the ionization probe and an inlet end (i.e., an end on the ionization probe side) of the heating chamber. The positions of the ionization probe and the heating chamber are controlled by the driving portions so that an ionization region that uses the ionization probe or an ionization region that uses the heating chamber is positioned near the ion inlet port of the mass spectrometer..
Hitachi High-technologies Corporation


07/07/16
20160195510 

Methods for determination of total homocysteine


Disclosed herein are simple, rapid and cost effective methods for determination of endogenous sulfhydryl amino acid species from a sample, example a sample in clinical practice. The method can include mixing of a biological sample with an internal standards which does not require pretreatment or derivatization and/or isotopic dilution.
Castle Medical, Llc


07/07/16
20160194590 

Structured biological samples for analysis by mass cytometry


Apparatus and methods for delivering biological samples to an icp source of a mass cytometer are disclosed. Biological material is disposed on a plurality of discrete sites on a carrier.
Fluidigm Canada Inc.


06/30/16
20160189949 

Triple quadrupole mass spectrometer


The present triple quadrupole mass spectrometer determines the relationship between a parameter, such as the mass-to-charge ratio of a precursor ion or that of a product ion, and the optimal collision-gas pressure giving the highest signal intensity in an mrm measurement, derives an approximate equation expressing that relationship, and stores the information representing the equation in an optimum collision-gas pressure calculation information storage section. When a measurement is to be performed, an analysis operator enters the mass-to-charge ratio of a precursor ion or product ion of a target compound.

06/30/16
20160189946 

Ion transport apparatus and mass spectrometer using the same


Within an intermediate vacuum chamber next to an ionization chamber maintained at atmospheric pressure, an electrode group of a radio-frequency carpet composed of a plurality of concentrically arranged ring electrodes is placed before a skimmer, with its central axis coinciding with that of an ion-passing hole. Each ring electrode has a circular radial sectional shape.

06/23/16
20160181081 

Multi-element isotopic measurement by direct coupling of a multi-cycle isotachophoresis technique and a mass spectrometry technique


A method for separating electrically charged species contained in a solution by an isotachophoresis method applied in an electrophoresis device, the isotachophoresis method being coupled to isotopic measurement using a mass spectrometer. The method notably comprises a step of stopping the voltage applied to the terminal of the electrophoresis capillary and transient application of a counter-pressure making it possible to utilize the length of the capillary several times and extend the separation distance artificially..

06/23/16
20160181079 

Mass spectrometer inlet with reduced average flow


An interface configured to transfer ions produced at or near atmospheric pressure conditions into a mass spectrometer for mass analysis is provided. The interface includes a first conduit including an inlet configured to receive a fluid containing the ions and an outlet configured to direct the fluid containing the ions into the mass spectrometer.

06/23/16
20160181078 

Bubble removal from liquid flow into a mass spectrometer source


Methods and systems for delivering a liquid sample to an ion source are provided herein. In various aspects, the methods and systems can improve the stability of a flow of liquid sample delivered to an ion source.

06/23/16
20160181077 

Sample quantitation with a miniature mass spectrometer


The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte.

06/23/16
20160181076 

Tuning a mass spectrometer using optimization


Systems, methods, and apparatuses are provided for tuning a mass spectrometer. An optimization process can be performed to determine optimal parameters for various physical parameters of elements of the mass spectrometer.

06/23/16
20160178602 

Analytical detecting fuel markers


A gas chromatographic method for detecting a first marker and a second marker in a fuel in two channels: (i) a first capillary column coated with polysiloxane and a second capillary column coated with polyethylene glycol; and (ii) a third capillary column coated with polymethylphenylsiloxane and a fourth deactivated capillary column. The steps are: (a) introducing a first sample into the first column to produce a first effluent; (b) introducing only a portion of the first effluent into the second column to produce a second effluent; (c) allowing the second effluent to pass through a mass spectrometer; (d) introducing a second sample into the third column to produce a third effluent; (e) introducing only a portion of the third effluent into the fourth column to produce a fourth effluent; (f) allowing the fourth effluent to pass through a mass spectrometer..

06/16/16
20160172180 

Methods, apparatus, and system for mass spectrometry


A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments.
The Massachusetts Institute Of Technology


06/16/16
20160172177 

Intermittent mass spectrometer inlet


An intermittent sample inlet device and methods for use of the intermittent sample inlet device are described that include an orifice plate with an entrance orifice and a rotating skimmer with a skimmer orifice, where the rotating skimmer is disposed between the orifice plate and a vacuum chamber wall. The rotating skimmer rotates so that the skimmer orifice intermittently aligns with the entrance orifice and allows an ion sample to pass through to a mass analyzer..
Smiths Detection Inc.


06/16/16
20160172173 

Cascaded-signal-intensifier-based ion imaging detector for mass spectrometer


A detector system for a mass spectrometer comprises: a metal channel dynode (mcd) comprising at least one perforated metal plate configured to receive the exiting ions and eject electrons in response; a plurality of electron-to-photon converters arranged in a parallel stacked configuration, each such converter comprising a substrate plate having a phosphor coating on a first face; and an electrode film disposed on the phosphor coating; at least one photocathode, each of the at least one photocathode disposed between a respective pair of the plurality of electron-to-photon converters; an optical detector optically coupled a last one of the electron-to-photon converters; and at least one direct current power supply configured to apply, in operation, a respective bias electrical potential to the mcd and each of the electrode films and photocathodes.. .
Thermo Finnigan Llc


06/16/16
20160172172 

High-voltage power unit and mass spectrometer using the power unit


An excessive overshoot preventing unit (16) is connected to a loop in which a command voltage vf according to a difference between: a voltage obtained by dividing an output voltage vout as a high voltage; and a control voltage v cont set from the outside is obtained and fed back to each of drive circuits (3 and 5) of a positive voltage generating unit (2) and a negative voltage generating unit (4). The excessive overshoot preventing unit (16) clamps the command voltage vf at a voltage value according to the control voltage vcont.
Shimadzu Corporation


06/16/16
20160172090 

Adjustment mechanism


A magnetic adjustment mechanism 100 comprising a chamber 10, an element 12 pivotally mounted within the chamber 10 and comprising a magnetic portion 14, and a magnetic actuator 18 arranged outside the chamber 10 to allow magnetic coupling with the magnetic portion 14 of the element 12 such that movement of the magnetic actuator 18 causes an adjustment of the position of the element 12. The adjustment mechanism 100 may be used within a vacuum chamber of a mass spectrometer to control the position of a moveable element from outside the chamber..
Thermo Fisher Scientific (bremen) Gmbh


06/16/16
20160169845 

Mass spectrometer


The objective of the present invention is to improve the robustness, sensitivity, and maintainability of a mass spectrometer to which a liquid chromatograph can be connected. This mass spectrometer includes: an ion source; a mass spectrometry unit; a plurality of flat plates used as electrodes having openings through which ions can be introduced to the mass spectrometer from an orthogonal direction along an ion introduction axis; a porous member provided between the mass spectrometry unit and the plurality of flat plates; and a mechanism for feeding gas to the plurality of flat plates for the side opposite from the ion introduction direction; the plurality of flat plates being disposed under atmospheric pressure, and the plurality of electrodes being set at a temperature higher than room temperature..
Hitachi High-technologies Corportion


06/16/16
20160169837 

Mass spectrometer


A closed-loop ion guide 1 is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. Ions are injected into the closed-loop ion guide 1 and may make several circuits of the closed-loop ion guide 1 before being ejected from the ion guide 1.
Micromass Uk Limited


06/09/16
20160163530 

Systems for separating ions and neutrals and methods of operating the same


A mass spectrometer system includes a pulsed ion source configured to generate ionized molecules and neutral molecules. The system also includes a first enclosure coupled in flow communication with the pulsed ion source.
Morpho Detection, Llc


06/09/16
20160163529 

Frequency scan linear ion trap mass spectrometry


An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an rf frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the rf to x and y electrodes.. .
Academia Sinica


06/09/16
20160163528 

Interface for an atmospheric pressure ion source in a mass spectrometer


The invention relates to a mass spectrometer having an ion source region at substantially atmospheric pressure in which ions are formed from a liquid sample. The mass spectrometer further has an interface for transmitting the formed ions from the ion source region into a vacuum region which is held at a pressure level substantially below the atmospheric pressure and where the formed ions are further processed.
Bruker Daltonics, Inc.


06/09/16
20160163527 

Ionizer and mass spectrometer


In the ionizer of the present invention, a stream of gas spouted from a nozzle (18) of a dart ionization unit (10) vaporizes and ionizes the components in a sample (25). Gaseous sample-component molecules which have not been ionized by that process are subsequently ionized by a reaction with a reactant ion produced by a corona discharge generated from a needle electrode (20).
Public University Corporation Yokohama City Univer Sity


06/09/16
20160163526 

Mass spectrometer


A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider.
Micromass Uk Limited


06/09/16
20160163525 

Mass spectrometer device and method using scanned phase applied potentials in ion guidance


An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser.
Micromass Uk Limited


06/09/16
20160163524 

Zero voltage mass spectrometry probes and systems


The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer).
Purdue Research Foundation


06/09/16
20160161404 

System using laser-scatter measurement instrument for organism identification and related network


An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples.
Bacterioscan Ltd


06/09/16
20160160641 

On-site mass spectrometry for liquid and extracted gas analysis of drilling fluids


An example method for analyzing drilling fluid used in a drilling operation within a subterranean formation may include receiving a drilling fluid sample from a flow of drilling fluid at a surface of the subterranean formation. A chemical composition of the drilling fluid sample may be determined using a mass spectrometer.
Halliburton Energy Services, Inc.


06/02/16
20160155624 

Multi-reflecting mass spectrometer with high throughput


Method and embodiments are provided for tandem mass spectrometer designed for extremely large charge throughput up to 1e+10 ion/sec. In one operation mode, the initial ion flow with wide m/z range is time separated in a trap array.
Leco Corporation


06/02/16
20160153944 

Ring shaped counter electrode to improve beam stability and compound sensitivity on a ceramic tile type microfluidic device


An interface for a mass spectrometer is disclosed comprising a microfluidic substrate, tile or cartridge 1 comprising a liquid chromatography separation column and an electrospray emitter 2. A counter electrode 4 is arranged downstream of a tip of the electrospray emitter 2 and is arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture 5 of a mass spectrometer..
Micromass Uk Limited


06/02/16
20160153060 

Method for species identification by using molecular weights of nucleic acid cleavage fragments


A method for species identification by using molecular weights of nucleic acid cleavage fragments, comprising steps of: performing a polymerase chain reaction and a nucleic acid cleavage reaction to cleave the nucleic acid sequence of the to-be-identified species into multiple nucleic acid cleavage fragments having different molecular weights; measuring the molecular weights of the nucleic acid cleavage fragments by using a mass spectrometer; comparing the molecular weight of each nucleic acid cleavage fragments of the to-be-identified species with molecular weights of nucleic acid cleavage fragments of a known species in a database; determining a number n of the identical nucleic acid cleavage fragments between the two species; and calculating a ratio n/m of the number n to the total number m of the nucleic acid cleavage fragments of the known species, wherein the ratio n/m represents similarity between the to-be-identified species and the known species.. .
Tech-knowhow Corp.


05/26/16
20160148796 

Constraining arcuate divergence in an ion mirror mass analyser


A charged particle analyzer apparatus comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner, whereby when the electrode systems are electrically biased the mirrors create an electrical field comprising opposing electrical fields along z; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyzer whilst the beam orbits around the axis z, the analyzer further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces. A mass spectrometer system comprising a plurality of the charged particle analyzers arranged as a parallel array..
Thermo Fisher Scientific (bremen) Gmbh


05/26/16
20160148795 

Time-of-flight mass spectrometers with cassini reflector


The invention relates to embodiments of high-resolution time-of-flight (tof) mass spectrometers with special reflectors. The invention provides reflectors with ideal energy and solid angle focusing, based on cassini ion traps, and proposes that a section of the flight path of the tof mass spectrometers takes the form of a cassini reflector.
Bruker Daltonik Gmbh


05/26/16
20160148792 

Mass spectrometer with bypass of a fragmentation device


A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer..
Micromass Uk Limited


05/26/16
20160146796 

High sensitivity quantitation of peptides by mass spectrometry


The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels).
Anderson Forschung Group, Inc.


05/19/16
20160141167 

Collision cell


A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis.
Thermo Fisher Scientific (bremen) Gmbh


05/12/16
20160133448 

Systems and methods for calibrating gain in an electron multiplier


Method for operating a mass spectrometer includes supplying a quantity of ions to an ion detector. The ion detector can include a conversion dynode operating in a first polarity and an electron multiplier.
Thermo Finnigan Llc


05/12/16
20160131626 

Methods for tracing fluid migration


The disclosure relates to application of a signature elemental tracer referred to herein as a signature). It comprises a selection of a small amount of a unique combination of a non-radioactive isotope or variant of a particular element or elements with stable isotopes, different from the natural-occurring combination of the elements in question.
New Century Financial Capital, Llc


05/05/16
20160126073 

Pathology interface system for mass spectrometry


A diagnostic system and method that includes a non-transitory computer readable medium storing machine executable instructions executable by the processor for altering tissue images, the instructions that further includes an input interface configured to receive a plurality of tissue images, the input interface generating enhanced resolution images from the plurality of tissue images for viewing, an annotation interface for positioning coordinates of interest on the enhanced resolution images, and a matrix model configured to evaluate the coordinates of interest on the enhanced resolutions to generate discrete coordinates, the matrix model using the discrete coordinates in performing mass spectrometer analysis to form at least one viewing image. The system also includes a user interface configured to provide at least one viewing image to a user at the display..
Vanderbilt University


05/05/16
20160123936 

Versatile ambient ionization-based interface for lc/ms


An apparatus (10) for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (16), which defines a flow passage (18) and is configured to supply the liquid sample. The fluid conduit (16) has an outer surface and a micro-hole (30) through the outer surface into the flow passage (18).
Ohio University


04/28/16
20160118238 

Compact mass spectrometer


A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar.
Micromass Uk Limited


04/28/16
20160118235 

Mass spectrometer


In a pause time assigned for switching voltage applied to a quadrupole mass filter or other ion transport optical system so as to switch the mass-to-charge ratio of a target ion in an sim measurement, the polarity of direct-current voltage applied to a pre-quadrupole mass filter is temporarily reversed. The voltage polarity reversal time is changed according to length of the pause time so that the ion intensity can sufficiently rise by the time the next dwell time begins.
Shimadzu Corporation


04/28/16
20160118234 

Contamination filter for mass spectrometer


Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss..
Dh Technologies Development Pte. Ltd.


04/21/16
20160111521 

Threshold adjustment for quantum dot array devices with metal source and drain


Incorporation of metallic quantum dots (e.g., silver bromide (agbr) films) into the source and drain regions of a mosfet can assist in controlling the transistor performance by tuning the threshold voltage. If the silver bromide film is rich in bromine atoms, anion quantum dots are deposited, and the agbr energy gap is altered so as to increase vt.

04/21/16
20160111271 

Time-of-flight mass spectrometer with spatial focusing of a broad mass range


The invention relates to time-of-flight mass spectrometers which operate with pulsed ionization of superficially adsorbed analyte substances and with an improvement in the mass resolution by means of a time-delayed start of the ion acceleration; in particular with ion-accelerating voltages which change over time after a delayed start in order to obtain a constant mass resolution over broad mass ranges. Since the varying acceleration produces a broadening of the ion beam at right angles to the direction of flight, and this broadening increases with the ion mass, the invention proposes to compensate, to the desired extent, for the broadening of the ion beam with the aid of an additional ion-optical lens whose voltage is also varied over time.

04/21/16
20160111270 

Glow discharge mass spectrometry


A glow discharge mass spectrometry device and method, the device including a glow discharge lamp (1), gas flow-injection elements, the glow discharge lamp being suitable for forming an ablation plasma in the presence of a plasma gas, and a mass spectrometer. The device further includes heating elements (30, 31) suitable for heating a gas flow (38) upstream of a cell (2), the gas flow-injection elements being suitable for injecting into the glow discharge cell a gas flow (38) heated to a temperature t for a duration d, and pumping elements (7, 27) being designed to pump a flow of gaseous species (17, 37) out of the cell for the duration d, so as to decontaminate the surface of the sample (4) and/or the inner walls of the glow discharge cell (2) before an ablation plasma (5) is ignited..

04/21/16
20160111269 

Mass spectrometer, use thereof, and the mass spectrometric examination of a gas mixture


The disclosure relates to a mass spectrometer for mass spectrometric examination of gas mixtures, including: an ionization device and an ion trap for storage and mass spectrometric examination of the gas mixture. In one aspect of the disclosure, the ionization device is embodied for supplying ions and/or metastable particles of an ionization gas and/or for supplying electrons to the ion trap for ionizing the gas mixture to be examined and the mass spectrometer is embodied to determine the number of ions and/or metastable particles of the ionization gas present in the ion trap and/or the number of ions of a residual gas present in the ion trap prior to examining the gas mixture.

04/21/16
20160111266 

Compact mass spectrometer


A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber.

04/21/16
20160109336 

Method and system for determining the concentration of an analyte in a fluid sample


A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected.

04/21/16
20160109333 

Pressure-drop device


Pressure-drop device, useful for gas chromatographs or mass spectrometers, containing a planar base plate, a cover plate, a gas inlet opening, and a gas outlet opening, which are connected by a capillary groove, wherein the capillary groove is embodied as an etched groove or pressed groove in the base plate and covered by the cover plate and wherein a plurality of pressure-drop devices can be connected to form a module.. .

04/14/16
20160104611 

Space focus time of flight mass spectrometer


A time of flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the time of flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times at of ions arriving at the ion detector..

04/14/16
20160103106 

Reference sample for analysis


A reference sample for analysis that is optimal for calibration of a pyrolysis gas chromatograph-mass spectrometer and with which precise calibration is always possible by preventing a reference substance from evaporating is provided. A reference sample sheet 1 is provided by distributing a target component or target components with a uniform normality in a base made of a high polymer material, and the reference sample sheet 1 is rolled up so that the target component or target components can be prevented from evaporating from the reference sample sheet 1 even in the case where a component has volatility.

04/14/16
20160101446 

Method of cleaning turbine blades


In a process for cleaning contaminating silicon dioxide sio2 off of turbine blades, silicon dioxide that is on the turbine blades is reduced selectively in a vacuum process that takes place in dry conditions and at elevated temperature inside a high vacuum furnace, by feeding gas having a reducing action, consisting of hydrogen gas or carbon monoxide, is introduced into the high vacuum furnace. The temperature inside the high vacuum furnace is at least about 1000 degrees celsius, and the residence time of the turbine blades in the high vacuum furnace is determined with reference to the diminishment of the sio concentration, as analysed with a mass spectrometer.

04/07/16
20160099136 

Systems and methods for acquiring data for mass spectrometry images


Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.


04/07/16
20160097748 

Autonomous ambient air sampling system for monitoring semi-volatile/non-volatile organic compounds


An automated ambient air sampling system and method for monitoring organic compounds that may provide continuous data, the system including a thermal desorption system, an injection port, a pre-concentration system, a gas chromatograph and an ion trap mass spectrometer, wherein an air sampling chamber may also function as a thermal desorption chamber.. .
Brigham Young University


03/31/16
20160093482 

Modulation of instrument resolution dependant upon the complexity of a previous scan


Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor.
Dh Technologies Development Pte. Ltd.


03/31/16
20160093480 

Compact mass spectrometer


A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar.
Micromass Uk Limited


03/31/16
20160093479 

Compact mass spectrometer


A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber.
Micromass Uk Limited


03/31/16
20160091386 

Sniffing leak detector having a nanoporous membrane


A sniffing leak detector for sucking in and analyzing gas, including a sniffing probe for sucking in the gas, a gas-conveying pump connected to the sniffing probe, and a mass spectrometer connected to a vacuum pump for analyzing the sucked-in gas in a high vacuum. The gas flow through the sniffing probe is conducted along a membrane having gas-permeable pores.
Inficon Gmbh


03/24/16
20160086785 

Methods and devices for generating double emulsions


The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer.
University Of Washington Through Its Center For Commercialization


03/24/16
20160086784 

Ionization chamber with temperature-controlled gas feed


The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet.
Bruker Daltonik Gmbh


03/24/16
20160086782 

Species detection using mass spectrometry


Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (mrm) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer.
Dh Technologies Development Pte. Ltd.




Mass Spectrometer topics: Mass Spectrometer, Spectrometer, Mass Spectrometry, Spectrometry, Downstream, Coordinates, Quantitative, Chromatograph, Data Processing, Biomolecule, Data Acquisition, Electrical Signal, Data Compression, Fragmentation, Irradiation

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