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Mass Spectrometer patents

      

This page is updated frequently with new Mass Spectrometer-related patent applications.




 Blanking out of pulses in pulsed lasers for ldi mass spectrometers patent thumbnailnew patent Blanking out of pulses in pulsed lasers for ldi mass spectrometers
The invention relates to optically pumped and pulsed solid-state lasers which are used in mass spectrometers in particular for ionization by matrix-assisted laser desorption (maldi) and which operate at pulse frequencies of up to 10 kilohertz or even higher. The invention proposes that, instead of interrupting the clocked sequence of the laser operation, individual light pulses or groups of light pulses are blanked out so that subsequent light pulses do not have a higher energy density, in accordance with the requirements for ldi processes.
Bruker Daltonik Gmbh


 Mass spectrometer patent thumbnailnew patent Mass spectrometer
A mass spectrometer includes a beam radiator radiating a beam to a sample. A laser radiator radiates laser light onto an irradiation surface of a surface of the sample irradiated with the beam or above the irradiation surface.
Kabushiki Kaisha Toshiba


 Methods and systems for cell state quantification patent thumbnailnew patent Methods and systems for cell state quantification
Systems, methods, libraries, kits, and computer software tools are provided for designing and producing engineered cells. Such engineered cells can be used for cell state quantification, such as genome, transcriptome and/or proteome quantification.
Ginkgo Bioworks, Inc.


 Methods for operating a system comprising a coupled mass spectrometer and ion mobility spectrometer patent thumbnailnew patent Methods for operating a system comprising a coupled mass spectrometer and ion mobility spectrometer
A method of operating a system comprising a chromatograph, an ion source, a mass spectrometer having a mass analyzer and an ion mobility spectrometer interposed between the ion source and the mass analyzer, comprising: performing a first chromatographic and mass analysis of a sample while operating the ion mobility spectrometer in non-dispersive mode, wherein a respective ion-signal-acquisition time (at) and a corresponding loss-of-ion-signal time (lt) are identified for each detected m/z ratio that corresponds to a precursor-ion m/z ratio of interest; and performing a second chromatographic and mass analysis of the sample during which, for each identified at and lt, the corresponding respective precursor ion is fragmented to generate product ions and the product ions are detected by the mass analyzer, wherein the ion mobility spectrometer is operated in dispersive mode such that ions of said each respective precursor-ion species are preferentially transmitted therethrough spectrometer to the mass analyzer.. .
Thermo Finnigan Llc


 Vacuum pump and mass spectrometer patent thumbnailnew patent Vacuum pump and mass spectrometer
One or more through-holes communicating with one or more of the plurality of screw grooves are formed at the cylindrical stator, a total of circumferential dimensions of the one or more through-holes formed at the cylindrical stator is set at equal to or greater than a circumferential dimension of an outer peripheral surface region of the cylindrical stator facing the second suction port, and a gas path through which inflow gas through the second suction port is guided to a screw groove is provided, the one or more through-holes penetrating through the screw groove and the screw groove being apart from the region facing the second suction port.. .
Shimadzu Corporation


 System and  an integrated satellite platform patent thumbnailnew patent System and an integrated satellite platform
A system, method, and computer-readable storage devices for a 6u cubesat with a magnetometer boom. The example 6u cubesat can include an on-board computing device connected to an electrical power system, wherein the electrical power system receives power from at least one of a battery and at least one solar panel, a first fluxgate sensor attached to an extendable boom, a release mechanism for extending the extendable boom, at least one second fluxgate sensor fixed within the satellite, an ion neutral mass spectrometer, and a relativistic electron/proton telescope.
U.s.a. As Represented By The Administrator Of The National Aeronautics And Space Administration


 Glow discharge ion source patent thumbnailGlow discharge ion source
A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber.
Micromass Uk Limited


 Ion guide with orthogonal sampling patent thumbnailIon guide with orthogonal sampling
A mass spectrometer is disclosed comprising a rf ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the rf ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar..
Micromass Uk Limited


 Data processing system and program for chromatograph mass spectrometer patent thumbnailData processing system and program for chromatograph mass spectrometer
In a chromatogram mass spectrometer's data processing system, if the intensity of a target peak originating from a target component at a target mass-to-charge ratio is equal to or higher than a threshold, the mass-to-charge ratio of a peak having a signal intensity lower than the threshold on the mass spectrum corresponding to the point in time where the target peak appears is designated as a correction mass-to-charge ratio. A mass spectrum at a point in time in the target peak where the signal intensity does not exceed the threshold is acquired.
Shimadzu Corporation


 Mass spectrometry method and mass spectrometer patent thumbnailMass spectrometry method and mass spectrometer
In a mass spectrometry method for performing a qualitative and/or quantitative determination of an analyte compound contained in a sample, using a mass chromatogram acquired for one or a plurality of ions selected as a reference ion from the ions produced from the analyte compound, the present method includes the steps of: setting one or a plurality of reference-ion candidates for each of the one or a plurality of reference ions; acquiring a mass chromatogram of the sample for each of the set reference-ion candidates; calculating a shape similarity between a peak appearing at a predetermined position on the mass chromatogram and a preset model peak; and designating, as the reference ion, a reference-ion candidate corresponding to a peak having the shape similarity equal to or higher than a predetermined value.. .
Shimadzu Corporation


Mass spectrometer with digital step attenuator

A method is disclosed comprising passing a signal output from a detector through a programmable attenuator or a programmable amplifier prior to digitising the signal, and switching an attenuation factor or gain factor of the programmable attenuator or the programmable amplifier one or more times during a data acquisition period.. .
Micromass Uk Limited

Paper cone tip, and paper cone spray ionization mass spectrometry using the same

A paper cone tip, having a triangular-pyramidal shape with a vertex angle of 12.5° to 45°, and to a paper cone spray ionization mass spectrometry (pcsi ms) method using a paper cone tip, including: preparing the paper cone tip having a triangular-pyramidal shape; placing a measuring sample in the paper cone tip and locating the paper cone tip in front of a mass spectrometer; and adding a spraying solvent to the paper cone tip and applying a voltage thereto. The paper cone tip having a triangular-pyramidal shape is suitable for use in pcsi ms for the direct analysis of solid samples of raw materials, and the three-dimensional paper cone tip serves as a sample container, a solid-liquid extraction chamber, an analyte transport channel, and an electrospray tip..
Hankuk University Of Foreign Studies Research & Business Foundation

Mass spectrometer data acquisition

A data acquisition system for a tof mass spectrometer comprises a processing module and a data collection module. The processing module generates a stream of data comprising, for each respective transient of a first scan, a set of time-intensity related parameter pairs.
Micromass Uk Limited

Mass spectrometer with reduced potential drop

A method of mass spectrometry is disclosed comprising providing a first device and a second device disposed downstream of the first device. The method further comprises introducing a potential difference between the exit of the first device and the entrance of the second device and reducing the total potential drop across the first and second devices by applying a reverse axial electric field to the first device and/or the second device.
Micromass Uk Limited

Microbial identification and quantitation using ms cleavable tags

Systems and methods are provided for microbial identification using cleavable tags. Control information is sent to a mass spectrometer to select a peptide labeled with a first tag of a known microbe, fragment the labeled peptide of the known microbe, and monitor for an intensity of the first tag in an mrm method using a processor.
Dh Technologies Development Pte. Ltd.

Dynamic range improvement for isotope ratio mass spectrometry

In a mass spectrometer, a mass-to-charge dispersive element separates received ions spatially according to their mass-to-charge ratios, to provide a dispersed ion beam thereby. An ion detection arrangement that detects the dispersed ion beam comprises: at least one primary ion detector, each detecting spatially separated ions having mass-to-charge ratios within a respective desired range and each providing a respective main beam signal based on its respective detected ions; and at least one secondary ion detector, each detecting ions having mass-to-charge ratios outside all of the desired ranges simultaneously with the at least one primary ion detector detecting the spatially separated ions and each providing a respective background signal based on its respective detected ions.
Thermo Fisher Scientific (bremen) Gmbh

Mirror lens for directing an ion beam

An electrostatic dual-mode lens assembly is provided for selectively transmitting or reflecting an ion beam in a mass spectrometer. The assembly comprises at least one electrode that provides a switchable electric field that, during a first mode of operation, directs an ion beam that enters the assembly along a first path so that the beam is transmitted through the assembly along the first path, and during a second mode of operation, directs an ion beam that enters the assembly along the first path so that the ion beam is reflected by the electric field and exits the assembly along a second path.
Thermo Fisher Scientific (bremen) Gmbh

Detector and slit configuration in an isotope ratio mass spectrometer

A method of configuring a faraday detector in a mass spectrometer is described. The mass spectrometer defines a central ion beam axis i, and the faraday detector is moveable relative to the central ion beam axis i.
Thermo Fisher Scientific (bremen) Gmbh

Mass spectrometer with interleaved acquistion

A method of mass spectrometry is disclosed comprising passing ions through a first stage and a second stage of a mass spectrometer and monitoring a first ion acquisition for a first dwell time extending from a time t1 to a time t1+tdwell1. The method further comprises reconfiguring the mass spectrometer or one or more components of the mass spectrometer to monitor a second ion acquisition and setting the first stage to transmit ions of the second ion acquisition at a time t, wherein t<t1+tdwell1.
Micromass Limited Uk

Quantitative measurements of elemental and molecular species using high mass resolution mass spectrometry

A method for generating a mass spectrum of sample ions using a multi-collector mass spectrometer is disclosed. The mass spectrometer includes a spatially dispersive mass analyser to direct the sample ions into a detector chamber.
Thermo Fisher Scientific (bremen) Gmbh

Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences

A method of checking or adjusting the calibration of a mass spectrometer is disclosed. The method comprises fragmenting parent or precursor ions and generating fragment or product ion mass spectral data and recognising first neutral loss ions in the fragment or product ion mass spectral data.
Micromass Uk Limited

Multi-trace quantitation

Systems and methods are provided for calculating the area of a peak profile using information from one or more correlated peak profiles. One or more compounds are separated from a mixture over time using a separation device.
Dh Technologies Development Pte. Ltd.

High pressure mass resolving ion guide with axial field

A mass spectrometer is disclosed comprising a first mass filter comprising a plurality of electrodes and a first device arranged and adapted to generate an axial force which drives at least some ions axially through or along the first mass filter and a quadrupole mass filter or mass analyser arranged downstream of the mass filter.. .
Micromass Uk Limited

Mass spectrometer

Methods and apparatus for operating a mass spectrometer are described. In various aspects, ions of a mass range of interest may be mass-selectively ejected from an accumulation ion trap into a multi-ion trap structure.
Dh Technologies Development Pte Ltd.

Multi-reflecting time-of-flight mass spectrometer with axial pulsed converter

Apparatuses (41, 91, 111, 115, 121, 151) and methods (31) for time-of-flight mass spectrometry providing effective pulsed conversion of continuous ion beams into pulsed ion packets is disclosed. Bunching of energetic continuous ion beams forms ion packets, which are filtered by a subsequent isochronous energy filter (49, 79, 81-84, 110).
Leco Corporation

Ion source for mass spectrometry

Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling.
Dh Technologies Development Pte. Ltd.

Data independent acquisition of product ion spectra and reference spectra library matching

Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor.
Eth Zürich

Mass spectrometry method, mass spectrometry , and mass spectrometric data processing program

In a mass spectrometric method of the invention, a mass spectrometer (2) is used having a mass separation unit (231, 234) before and after a collision cell (232) for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum.
Shimadzu Corporation

Plasma generator using dielectric resonator

A dielectric resonator is excited at its natural resonant frequency to produce a highly uniform electric field for the generation of plasma. The plasma may be used in a optical or mass spectrometer..
Radom Corporation

Device for mass spectrometry

A device for mass spectrometry in continuous operation can be equipped with a focused electron beam source or laser radiation source. It can further include a vacuum chamber, a stage for placing the specimen, and an ion beam column with a plasma source for producing a primary ion beam and a secondary ion mass spectrometer for secondary ion analysis.
Tescan Brno, S.r.o.

Integrated sample processing for electrospray ionization devices

Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one esi emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one esi emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one esi emitter thereby preferentially directing analyte molecules out of the at least one esi emitter.
The University Of North Carolina At Chapel Hill

Mass spectrometer vacuum interface method and apparatus

A mass spectrometer vacuum interface can include a skimmer apparatus having a skimmer aperture and an internal surface. A method of operating the mass spectrometer vacuum interface can include establishing an outwardly directed flow along the internal surface of the skimmer apparatus..
Thermo Fisher Scientific (bremen) Gmbh

Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis

A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as hydrogen-deuterium exchange.
Micromass Uk Limited

Multiplex enzyme assay using mass spectrometer-based flow cytometer

The present invention generally relates to methods for the detection of enzymes using elemental analysis.. .
Fluidigm Canada Inc.

An electrostatic ion trap mass spectrometer utilizing autoresonant ion excitation and methods of using the same

Methods of operation of electrostatic ion trap mass spectrometers in which ions are autoresonantly driven at selected higher integer (>2) multiples of ion oscillation frequencies are provided. Excitation at multiples higher than the fundamental or double the fundamental ion oscillation frequency significantly improves both signal intensity and mass resolution.
Rutgers, The State University Of New Jersey

Process and measuring an organic solid sample by glow discharge spectrometry

A system and a process for measuring, by glow discharge spectrometry, the elemental and/or molecular chemical composition of an organic solid sample (10). The sample (10) is positioned so as to seal a glow discharge plasma reactor (2), a gaseous mixture including at least one inert gas and gaseous oxygen is injected into the reactor (2), the concentration of gaseous oxygen being between 0.1% and 15% by weight of the gaseous mixture, an electric discharge of radiofrequency type is applied to the electrodes of the plasma reactor (2) in order to generate a glow discharge plasma, and the solid sample (10) is exposed to the plasma so as to etch an erosion crater in the solid sample (10); at least one signal representative of an ionized species of negative charge is selected and measured using a mass spectrometer (4)..
Horiba Jobin Yvon Sas

Microwave cavity resonator detector

An ion detector system for a mass spectrometer is disclosed comprising a first device arranged and adapted to receive ions and emit or output first electrons and a microwave cavity resonator arranged and adapted to deflect the first electrons onto a first detector.. .
Micromass Uk Limited

Studies on real time ozone layer depletion monitoring using the negative ion mode of ion mobility spectrometry / atmospheric pressure ionization mass spectrometry (neg. mode ims/apims) in upper and lower atmosphere

The present invention provides a capability of ion mobility spectrometry/atmospheric pressure ionization mass spectrometry (ims/ms) in the negative ion mode for ozone detection and methods for ozone layer depletion monitoring in laboratory environment. Ammonium hydroxide vapors, as a dopant chemical, introduced to the inlet system of the ims/ms interfaced with the reaction sphere enables ozone ionized to be o3−.

Determining device for hydrocarbon emissions of motors

A determination device for hydrocarbon emissions of a thermal engine including an inspection probe for removing a sample volume from a liquid, a measurement channel for conducting the sample volume via an ion source apparatus to a broadband measurement apparatus that is configured to determine a spectrum to be measured in one step, wherein the ion source apparatus is configured for soft ionization and the measurement apparatus forms an intensity signal sequence across the mass spectrum and is configured as a simultaneously measuring “time-of-flight” detector or as a “double-focusing sector field mass spectrometer in mattauch-herzog geometry.”. .
Verwaltungsgesellschaft Für Emissionsanalyse Ug (haftungsbeschränkt)

Mass spectrometer

The mass spectrometer (1) provides an ionization chamber (11) therein with: a probe (15) having a sample to be measured flow path (155) for spraying a sample to be measured; and a standard sample flow path (255) for spraying a standard sample used for the calibration of the mass-to-charge ratio of the mass spectrum into the ionization chamber. The standard sample is intermittently introduced into the ionization chamber via a pulse valve (216).
Shimadzu Corporation

Ambient infrared laser ablation mass spectrometry (airlab-ms) with plume capture by continuous flow solvent probe

A new experimental setup for spatially resolved ambient infrared laser ablation mass spectrometry (airlab-ms) that uses an infrared microscope with an infinity-corrected reflective objective and a continuous flow solvent probe coupled to a fourier transform ion cyclotron resonance mass spectrometer is described. The efficiency of material transfer from the sample to the electrospray ionization emitter was determined using glycerol/methanol droplets containing 1 mm nicotine and is ˜50%.
The Regents Of The University Of California

Systems and methods for using interleaving window widths in tandem mass spectrometry

Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.

Systems and methods for acquiring data for mass spectrometry images

Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.

Cryofocused sampling of volatiles from air using peltier-assisted capillary microextraction

A cmv sampling device includes a thermoelectric cooler, a vacuum pump, and one or more holders for one or more capillary microextractor of volatiles (cmv) tubes. The holder thermally contacts the thermoelectric cooler and the vacuum pump is fluidly connected to the cmv tube.
The Florida International University Board Of Trustees

Systems and methods for using variable mass selection window widths in tandem mass spectrometry

Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.

Method for mass spectrometric examination of gas mixtures and mass spectrometer therefor

A method includes parallel or serial ionization of a gas mixture by activating at least two ionization devices operating using different ionization procedures, and/or by ionizing the gas mixture in a detector to which the gas mixture and ions and/or metastable particles of an ionization gas are fed. The method also includes detecting the ionized gas mixture in the detector for the mass spectrometric examination thereof.
Carl Zeiss Microscopy Gmbh

Particles containing detectable elemental code

The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (fc-ms) (fig. 1)..
Fluidigm Canada Inc.

Vacuum pump and mass spectrometer

A vacuum pump comprises: a first pump stage; a second pump stage provided downstream of the first pump stage; a first suction port provided on a suction side of the first pump stage; and a second suction port provided downstream of the first pump stage and communicating with the second pump stage. The first pump stage includes a siegbahn pump portion suitable for a small exhaust volume, and a turbo-molecular pump portion.
Shimadzu Corporation

Quasi-planar multi-reflecting time-of-flight mass spectrometer

A multi-reflecting, time-of-flight (mr-tof) mass spectrometer including two quasi-planar electrostatic ion mirrors extended along drill direction (z) and formed of parallel electrodes, separated by a field free region. The mr-tof includes a pulsed ion source to release ion packets at a small angle to x-direction which is orthogonal to the drill direction z.
Leco Corporation

Novel diagnostic gastric cancer

This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in n-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the n-glycan as compared to normal persons, n-glycan structures identified using the changes in n-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis..
Korea Advanced Institute Of Science And Technology

Coupling intermediate pressure regions

A method is disclosed for coupling a first chamber of a mass spectrometer or ion mobility spectrometer containing a first gas and a second chamber containing a second gas. The method comprises providing an intermediate region between the first and second chambers that is operated at a lower pressure to substantially prevent or reduce ingress of the first gas into the second chamber and/or of the second gas into the first chamber..
Micromass Uk Limited

Systems and methods for analyzing an extracted sample using an immiscible extraction solvent

The invention generally relates to systems and methods for analyzing an extracted sample using an immiscible extraction solvent. In certain embodiments, the invention provides a system for analyzing an analyte in a sample.
Purdue Research Foundation



Mass Spectrometer topics:
  • Mass Spectrometer
  • Spectrometer
  • Mass Spectrometry
  • Spectrometry
  • Downstream
  • Coordinates
  • Quantitative
  • Chromatograph
  • Data Processing
  • Biomolecule
  • Data Acquisition
  • Electrical Signal
  • Data Compression
  • Fragmentation
  • Irradiation


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    This listing is a sample listing of patent applications related to Mass Spectrometer for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mass Spectrometer with additional patents listed. Browse our RSS directory or Search for other possible listings.


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