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Mass Spectrometer patents



      
           
This page is updated frequently with new Mass Spectrometer-related patent applications. Subscribe to the Mass Spectrometer RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometer RSS RSS


Mass spectrometric ion storage device for different mass ranges

Bruker Daltonik

Mass spectrometric ion storage device for different mass ranges

Method of mass spectrometry and a mass spectrometer

Micromass Uk Limited

Method of mass spectrometry and a mass spectrometer

Method of mass spectrometry and a mass spectrometer

Micromass Uk Limited

Mass spectrometer, control system and methods of operating and assembling a mass spectrometer

Date/App# patent app List of recent Mass Spectrometer-related patents
03/19/15
20150080233
 Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry patent thumbnailMultiplexed imaging of tissues using mass tags and secondary ion mass spectrometry
A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (sims) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set.
The Board Of Trustees Of The Leland Stanford Junior University
03/19/15
20150076366
 Mass spectrometric ion storage device for different mass ranges patent thumbnailMass spectrometric ion storage device for different mass ranges
The invention relates to devices and methods for the storage of ions in mass spectrometers. The invention proposes the generation and superposition of two multipole fields of different order, independent of each other, in an rf multipole rod system.
Bruker Daltonik Gmbh
03/19/15
20150076341
 Method of mass spectrometry and a mass spectrometer patent thumbnailMethod of mass spectrometry and a mass spectrometer
The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas..
Micromass Uk Limited
03/19/15
20150076338
 Mass spectrometer, control system and methods of operating and assembling a mass spectrometer patent thumbnailMass spectrometer, control system and methods of operating and assembling a mass spectrometer
A mass spectrometer and methods for controlling a mass spectrometer are provided. In an exemplary embodiment, the mass spectrometer includes a plurality of discrete functional modules, each operable to perform a predetermined function of the mass spectrometer, wherein the modules are individually addressable and connected in a network.
Micromass Uk Limited
03/12/15
20150068279
 Electro-enhanced solid-phase microextraction method patent thumbnailElectro-enhanced solid-phase microextraction method
The electro-enhanced solid-phase microextraction (ee-spme) method involves extraction that is performed with an spme fiber, preferably made of polydimethylsiloxane (pdms), in the presence of an applied electric potential for a predetermined period of time. Polar analytes are extracted onto the fiber, which is the stationary phase.
King Fahd University Of Petroleum And Minerals
03/05/15
20150066421
 Method for following degassing rate by measuring partial pressures measured bymass spectrometry patent thumbnailMethod for following degassing rate by measuring partial pressures measured bymass spectrometry
Where m denotes the set of reference atomic masses, pi denotes the partial pressures for the atomic masses measured by the mass spectrometer, the coefficients αi denote preset weighting coefficients associated with each partial pressure pi, and n denotes a maximum atomic mass for which the partial pressure pi can be measured by the mass spectrometer.. .
03/05/15
20150066387
 Substance identification method and mass spectrometer using the same patent thumbnailSubstance identification method and mass spectrometer using the same
Ms1 and ms2 measurements of fractionated samples are performed. Based on the identification results and the s/n ratios of the ms1 peaks, an identification probability estimation model showing a relationship between the cumulative number of ms1 peaks and the number of ms1 peaks successfully identified through the ms2 measurements and identifications performed in ascending order of s/n ratio is created.
Shimadzu Corporation
03/05/15
20150064793
 Method of discerning substitution of carbohydrate esters patent thumbnailMethod of discerning substitution of carbohydrate esters
A method of testing for discerning substitution of carbohydrate ester includes the step of providing a predetermined amount of a solution. Further, the method also includes adding ammonium hydroxide and sodium borohydride to the solution.
Biologistics Llc
03/05/15
20150064739
 Analyzer patent thumbnailAnalyzer
An analyzer includes a pretreatment device and a mass spectrometer. The pretreatment device includes a solid phase extraction mechanism.
Hitachi High-technologies Corporation
03/05/15
20150060687
 Ion deflector for a mass spectrometer patent thumbnailIon deflector for a mass spectrometer
There is provided an ion deflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The ion deflector includes an electric field inducer arranged so as to establish at least one electrostatic field capable of deflecting ions travelling substantially along a first intended path of travel so as to travel substantially along a second intended path of travel..
Bruker Chemical Analysis Bv
02/26/15
20150053854

Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum


Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry..
Wayne State University
02/26/15
20150053853

Plume collimation for laser ablation electrospray ionization mass spectrometry


In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume.
The George Washington University
02/19/15
20150048255

Ion source for mass spectrometer and producing analyte ion stream


An ion source for a mass spectrometer and a method of ionizing a sample are disclosed. A droplet generator is configured to emit a stream of analyte droplets, which are ionized upon impact with a target, thus forming an ion stream.
Waters Technologies Corporation (a Delaware Corp)
02/19/15
20150048245

Ion optical system for maldi-tof mass spectrometer


An ion accelerator for a time-of-flight mass spectrometer includes a pulsed ion accelerator positioned proximate to a sample plate and having an electrode that is electrically connected to the sample plate. An accelerator power supply generates an accelerating potential on the ion accelerator electrode that accelerates a pulse of ions generated from the sample positioned on the sample plate.
Virgin Instruments Corporation
02/12/15
20150041641

Mass spectrometer


A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample.
Hitachi High-technologies Corporation
02/05/15
20150039233

Method for near real time surface logging of a hydrocarbon or geothermal well using a mass spectrometer


An automatic method for providing geological trends and real time mapping of a geological basin using a mass spectrometer. The method provides information from a mass spectrometer on fluid samples from a wellbore into a geochemical surface well log with graphical tracks in real time.
Selman And Associated, Ltd
02/05/15
20150037606

Electrolytic copper foil, cleaning fluid composition and cleaning copper foil


An electrolytic copper foil includes a copper foil body; and a iia-group metal adhered to a surface of the copper foil body, wherein a signal strength of the iia group metal is greater than 0.1% based on a signal strength of copper element as 100% analyzed by a secondary ion mass spectrometer. The present invention also provides a method for cleaning copper foil and a cleaning fluid composition which is used in the cleaning method..
Chang Chun Petrochemical Co., Ltd.
02/05/15
20150034821

Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system


Provided is an ionization apparatus including: a holder configured to hold a sample; a probe configured to determine a part to be ionized of the sample held by the holder; an extract electrode configured to extract ionized ions of the sample; a liquid supply unit configured to supply liquid to a part of a region of the sample; and a unit configured to apply a first voltage between the probe and the extract electrode, in which the first voltage is pulse-modulated.. .
Canon Kabushiki Kaisha
02/05/15
20150034820

Continuous operation high speed ion trap mass spectrometer


The present disclosure discusses a system and method for continuous operation of an ion trap mass spectrometer. The described system does not introduce ions into the ion trap in distinct trapping phase, rather the described system continuously injects ions into the ion trap while continuously scanning out the ions.
Mini-mass Counseling
02/05/15
20150034819

Multiple channel detection for time of flight mass spectrometer


An ion detector for a time of flight mass spectrometer is disclosed comprising a single microchannel plate which is arranged to receive ions and output electrons. The electrons are directed onto an array of photodiodes which directly detects the electrons.
Micromass Uk Limited
02/05/15
20150034818

Discontinuous atmospheric pressure interface


A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample.
Purdue Research Foundation
02/05/15
20150034816

Interface for mass spectrometry apparatus


There is provided an interface for use in sampling ions in a mass spectrometer, the interface being arranged for receiving a quantity of ions from an ion source and forming more than one ion beam therefrom, each ion beam being directed along a respective desired pathway.. .
Bruker Chemical Analysis Bv
02/05/15
20150034814

Maldi imaging and ion source


An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm.
Micromass Uk Limited
02/05/15
20150034813

Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis


A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as hydrogen-deuterium exchange.
Micromass Uk Limited
02/05/15
20150034812

Multi-dimensional chromatograph system


In a two-dimensional lc system configured to introduce components trapped in a trap column during a fractionation period t into a second-dimension column, separate components, and then detect the components using a mass spectrometer, a data collection unit receives a signal which indicates timing to delimit the fractionation period t, determines the first data item in the fractionation period t, adds measurement start point identification information to the first data item, and stores all the data in a data storage unit. A two-dimensional chromatogram creation unit recognizes the first data item in each fractionation period t from the read data, and create a two-dimensional chromatogram by aligning data so that the first data items will be aligned at the top along an abscissa..
Shimadzu Corporation
01/29/15
20150028743

Device for supplying voltage to the cathode of a mass spectrometer


A simplified device for voltage supply of the cathode of a mass spectrometer comprises a push-pull transformer, wherein, apart from the normal rectifier diodes (7, 9), a controlled rectifier (8, 10) is provided. The gate of the first transistor (8) is connected to the second output (30), and the gate of the second transistor (10) is connected to the first output (32) of the transformer.
Inficon Gmbh
01/29/15
20150028221

Methods of ion source fabrication


A method of ion source fabrication for a mass spectrometer includes simultaneously forming aligned component portions of an ion source using direct metal laser fusing of sequential layers. The method can further include forming the component portions on a base plate made from a ceramic material by applying fused powder to the base plate to build the component portions thereon..
Hamilton Sundstrand Corporation
01/29/15
20150028198

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction and having a space therebetween, the x direction being orthogonal to y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the x direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length..
Thermo Fisher Scientific (bremen) Gmbh
01/29/15
20150028197

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction, the x direction being orthogonal to y, characterized in that the mirrors are not a constant distance from each other in the x direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer.
Thermo Fisher Scientific (bremen) Gmbh
01/22/15
20150025813

Systems and methods for sequential windowed acquisition across a mass range using an ion trap


Systems and methods are provided to perform sequential windowed acquisition of mass spectrometry data. A mass range and a mass window width parameter are received for a sample.
Dh Technologies Development Pte. Ltd.
01/22/15
20150024510

Performing chemical reactions and/or ionization during gas chromatography-mass spectrometry runs


A gas chromatography-mass spectrometry (gc-ms) method that includes performing a first gc-ms run on a sample using a gas chromatography-mass spectrometry system. Performing the first gc-ms nm includes i) passing a first flow of a carrier gas carrying a first portion of the sample through a gas chromatograph to provide a first effluent; ii) generating first ions under protonation conditions by passing the first effluent through an atmospheric pressure ionization source; iii) passing the first ions through a mass spectrometer; and iv) recording first gc-ms data for the first ions.
Waters Technologies Corporation
01/22/15
20150021471

Electrostatic mass spectrometer with encoded frequent pulses


A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
Leco Corporation
01/22/15
20150021469

Interfacing capillary electrophoresis to a mass spectrometer via an impactor spray ionization source


A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a capillary electrophoresis (“ce”) separation device.
Micromass Uk Limited
01/22/15
20150021467

Segmented planar calibration for correction of errors in time of flight mass spectrometers


An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions.
Micromass Uk Limited
01/15/15
20150014523

Method for determining the maximum mass peak in mass spectrometry


A fast method for determining molecular mass using mass spectrometry has the following steps: specifying a first adjusting value (m1) of the mass spectrometer, recording the associated signal amplitude (a1), specifying a second adjusting value (m2) which is different to the first, measuring the associated second signal amplitude (a2), specifying a third adjusting value (m3) which is different to the first (m1) and the second (m2) adjusting value, measuring the associated third signal amplitude (a3), determining a quadratic function containing the measured amplitude values as y-values and the specified adjusting values as x-values, determining the maximum of the quadratic function, wherein the searched adjusting value is determined from the x-value of the maximum.. .
Inficon Gmbh
01/15/15
20150014522

First and second order focusing using field free regions in time-of-flight


In some embodiments, a time of flight mass spectrometer can comprise an input orifice for receiving ions, a first ion accelerator stage for accelerating the ions along a first path, at least one ion reflector for receiving said accelerated ions and redirecting said ions along a second path different than the first path, a detector for detecting at least a portion of the ions redirected by said at least one ion reflector, and at least first and second field free drift regions disposed between said first acceleration stage and said detector, wherein said second field free region is disposed in proximity of the detector. In some embodiments, the lengths of the field free drift regions can be selected so as to provide 1st and 2nd order corrections of the time of flight of the ions with respect to variation in their initial positions..
Dh Technologies Development Pte. Ltd.
01/15/15
20150013438

Analytical detecting sulfated oligosaccharides


The present invention describes an analytical method for detecting and quantitating poly-sulfated oligosaccharides, including fondaparinux sodium, using hydrophilic interaction ultra-performance liquid chromatography (hilic-uplc) coupled with a charged aerosol detector (cad) or a mass spectrometer (ms). This analytical method provides in-process control in a total synthesis of highly sulfated oligosaccharides by separation, quantification and mass identification.
Scinopharm Taiwan, Ltd.
01/08/15
20150012219

System for near real time surface logging of a geothermal well, a hydrocarbon well, or a testing well using a mass spectrometer


A system for providing geological trends and real time mapping of a geological basin. The system provides in real time, information from a mass spectrometer on fluid samples from a wellbore, and forms a geochemical surface well log with graphical tracks.
Selman And Associates, Ltd.
01/08/15
20150012218

Method for near real time surface logging of a geothermal well, a hydrocarbon well, or a testing well using a mass spectrometer


A method for providing geological trends and real time mapping of a geological basin by forming a geochemical surface well log. The method provides in real time, information from a mass spectrometer on fluid samples from a wellbore, into a geochemical well log template using computer instructions to create a plurality of graphical tracks.
Selman And Associates, Ltd.
01/08/15
20150008320

Method and improved sensitiivity in a mass spectrometer


An ion source and an ion guide chamber are provided. The ion guide chamber having a gas flow, the gas flow having a longitudinal velocity and a transverse velocity.
Dh Technologies Development Pte. Ltd.
01/08/15
20150008317

System and quantitation in mass spectrometry


A method of operating a tandem mass spectrometer system is disclosed including accumulating ions in an ion trap, transmitting a plurality of ions out of the ion trap into a timed-ion selector, applying a pulsed dc voltage to the timed-ion selector, the pulsed dc voltage being modulated to match an ejection time for selecting a first portion of ions from the plurality of ions, corresponding to a specific m/z window, transmitting the first portion of selected ions out of the timed-ion selector into a reaction cell, transmitting dissociation product ions and the remaining ions of the first portion of selected ions out of the reaction cell into a mass analyzer, and mass-selectively transmitting at least some of the fragment ions and the remaining ions of the first portion of selected ions out of the mass analyzer into a detector.. .
Dh Technologies Development Pte. Ltd.
01/08/15
20150008312

Generation of reagent ions for ion-ion reactions


An apparatus, system and method of providing that allow for the generation of reagent ions within an inner region of a mass spectrometer for use in ion-ion reactions such as ptrs and etd using a reagent ion generator. The location where these reagent ions are generated can be as close as possible to the point of action, or the reaction zone where the reagent ion and analyte ions will interact via ion-ion reactions to cause, e.g., ptrs and/or etd..
Dh Technologies Development Pte. Ltd.
01/08/15
20150008311

Reduction of cross-talk between rf components in a mass spectrometer


The invention generally relates to an assembly of a first rf component and a second rf component in a mass spectrometer, the first rf component comprising a first set of electrodes and the second rf component comprising a second set of electrodes, wherein the rf components are located and aligned end-to-end to one another, and wherein a transverse dimension of the electrodes of the first set is smaller than that of the electrodes of the second set. The assembly further comprises a conductive electric field screen located at an outer periphery of the first set of electrodes and facing the electrodes of the second set as to reduce rf electric field cross-talk between the electrodes of the first set and those of the second set.
Bruker Daltonics, Inc.
01/08/15
20150008310

Pulsed mass calibration in time-of-flight mass spectrometry


A method is provided for calibrating mass-to-charge ratio measurements obtained from a time-of-flight mass spectrometer used as a detector for a chromatographic system. The method can include introducing a calibrant material into the time-of-flight mass spectrometer after a sample is introduced to the chromatographic system, but before the analysis of the sample is complete, such that calibrant material and sample material are not present at the ion source of the mass spectrometer, contemporaneously, and back-flushing residual or leaking calibrant through a back-flush line and away from the mass spectrometer..
Zoex Corporation
01/01/15
20150004722

Method for fabricating light-emitting element and light-emitting element


A light-emitting element and its fabrication method are provided. The light-emitting element includes an el layer between a pair of electrode, and the el layer is formed by evaporation of an organic compound.
Semiconductor Energy Laboratory Co., Ltd.
01/01/15
20150001392

Mass analysis device


An object of the present invention is to prevent lowering of introduction efficiency of ions and to reduce labor for a cleaning operation. In order to solve the above problems, the present invention provides a mass spectrometer where ion introduction hole of an electrode is divided into a first region, a second region, and a third region, a central axis direction of the ion introduction hole in both or either one of the first region and the third region is different from a flow direction axis of the ion inside the ion introduction hole in the second region, and axes of the ion introduction hole in the first region and the third region are in an eccentric position relationship..
Hitachi High-technologies Corporation
01/01/15
20150001388

Droplet manipulation using gas-phase standing-wave ultrasound fields in ms sources


An ion source for a mass spectrometer is disclosed comprising an ionisation device which emits a stream of droplets and one or more ultrasonic transmitters which create one or more acoustic standing waves. The acoustic standing waves may be used to further nebulise the stream of droplets and induce internal mixing of the droplets..
Micromass Uk Limited
12/25/14
20140374591

In situ generation of ozone for mass spectrometers


In some embodiments, a mass spectrometer capable of performing ozid is disclosed that can provide ozone in situ within an evacuated chamber of the spectrometer, e.g., within a collision cell or within the vacuum chamber of the mass spectrometer. In some embodiments, a corona discharge generated within the evacuated chamber can be employed to convert an ozone precursor delivered to the chamber into ozone..
Dh Technologies Development Pte. Ltd.
12/25/14
20140374589

Method and improved sensitivity in a mass spectrometer


Ions are generated in a high pressure region and are passed into a vacuum chamber having an inlet and an exit aperture. The configuration of the inlet aperture and the pressure difference between the high pressure region and the vacuum chamber provides a supersonic free jet expansion that has a barrel shock of predetermined diameter.
Dh Technologies Development Pte. Ltd
12/25/14
20140374588

Method and improved sensitivity in a mass spectrometer


A method and apparatus is provided including an ion source for generating ions, a vacuum chamber having an inlet aperture for receiving ions and an exit aperture for passing ions from the vacuum chamber. At least one ion guide is provided between the inlet and exit apertures, the at least one ion guide having an entrance end and an exit end.
Dh Technologies Development Pte. Ltd.
12/25/14
20140374587

Ion group irradiation device and secondary ion mass spectrometer


The present invention provides an ion group irradiation device which includes: an ion source which generates an ion; and an ion group selecting unit which selects an ion group containing a cluster ion from ions released from the ion source, in an ion group irradiation device for irradiating a sample with the ion group, wherein the ion source has a pressure gradient forming unit for changing a pressure with which a material of the cluster ion is jetted, with time, the ion group selecting unit has a chopper which performs a chopping operation of selecting the ion group by passing and blocking the cluster ions in a traveling direction by the opening and closing of the chopper, and the chopper performs two or more times of the chopping operations per one time of a pressure gradient forming operation by the pressure gradient forming unit.. .
Canon Kabushiki Kaisha
12/25/14
20140374586

Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method


Provided is an ion group irradiation device for facilitating the distinction of peaks in secondary ion mass spectra. The ion group irradiation device for irradiating a sample with an ion group includes an ion source for generating ions, an ion group selecting unit configured to select, from the ions released from the ion source, two or more ion groups formed of ions having different average masses, and a primary ion irradiation unit configured to irradiate the sample with the two or more ion groups.
Canon Kabushiki Kaisha
12/25/14
20140374585

Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method


The present invention provides an ion group irradiation device for irradiating a sample with an ion group, comprising: an ion group selecting unit configured to select, from ions released from an ion source, at least two ion groups formed of ions having different average masses; and a primary ion irradiation unit configured to irradiate the sample with the at least two ion groups selected by the ion group selecting unit, wherein the ion group selecting unit selects at least one ion group and further selects the at least two ion groups from each of the selected at least one ion group.. .
Canon Kabushiki Kaisha
12/25/14
20140373646

Sample fixing member for time-of-flight secondary ion mass spectrometer


Provided is a sample fixing member for a time-of-flight secondary ion mass spectrometer that: can prevent the contamination of a solid sample; can stably fix the solid sample; and enables accurate detection of a secondary ion in a time-of-flight secondary ion mass spectrometer. A sample fixing member for a time-of-flight secondary ion mass spectrometer of the present invention includes a fibrous columnar structure including a plurality of fibrous columnar objects each having a length of 200 μm or more..
Nitto Denko Corporation
12/18/14
20140372048

Data record size reduction at fixed information content


A time-of-flight (tof) mass spectrometer analyzes a sample producing a time series of data points representing amounts of detected ions per unit time. A spectrometer resolution, a spectrometer digitization time period, and a minimum number points per peak needed to maintain the information content of a peak are received.
Dh Technologies Development Pte. Ltd.
12/18/14
20140367566

Mass spectrometric ion storage device for different mass ranges


The invention relates to devices and methods for the storage of ions in mass spectrometers. The invention proposes the generation and superposition of two multipole fields of different order, independent of each other, in an rf multipole rod system.
Bruker Daltonik Gmbh
12/18/14
20140367565

Method of screening a sample for the presence of one or more known compounds of interest and a mass spectrometer performing this method


A method of screening a sample for the presence of one or more known compounds of interest is disclosed. A fragmentation device is repeatedly switched between a fragmentation mode of operation and a non-fragmentation mode of operation.
Micromass Uk Limited
12/18/14
20140367564

Method of avoiding space charge saturation effects in an ion trap


A mass spectrometer is provided comprising a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects..
Micromass Uk Limited
12/11/14
20140361163

Mass spectrometer and driving ion guide


A method of operating an electrode changeover switch which switches the connection state of electrodes, the electrode changeover switch is provided in the wiring path between eight electrodes through, arranged rotation-symmetrically about ion optical axis, and voltage generation switch which generates square wave high voltage ±v. When switch is switched as shown in the drawing, two circumferentially adjacent rod electrodes are connected to form one set, a square wave voltage of opposite phase is applied to circumferentially adjacent sets, and an effectively quadrupole electric field is formed.
12/11/14
20140361162

Imaging mass spectrometer and a mass spectrometry


An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process.. .
12/11/14
20140361158

Methods for predictive automatic gain control for hybrid mass spectrometers


A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer.. .
12/04/14
20140357502

Windowing combined with ion-ion reactions for chemical noise elimination


In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location.
12/04/14
20140353496

Gas diffuser ion inlet


In some embodiments, a gas diffuser for use in a mass spectrometer is disclosed that can provide a controlled expansion of an ion-containing gas so as to reduce gas velocity for entry into subsequent stages of the mass spectrometer, e.g., a mass analyzer. In some embodiments, the controlled expansion of the gas is provided by flowing the gas through a channel whose cross-sectional area change, e.g.
12/04/14
20140353491

Creating an ion-ion reaction region within a low-pressure linear ion trap


Methods and systems for creating a region for ion-ion reactions within a mass spectrometer are described. In various aspects, the methods and systems can confine a first group of ions in a sub-volume of a multipole ion trap, and introduce a second group of oppositely-charged ions into the multipole ion trap while maintaining the first group of ions within the sub-volume.
12/04/14
20140353484

Strategic dynamic range control for time-of-flight mass spectrometry


A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters.
11/27/14
20140346343

Collision cell


A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis.
11/27/14
20140346342

Mass spectrometer with beam expander


A mass spectrometer is disclosed comprising a rf confinement device, a beam expander and a time of flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the rf confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the time of flight mass analyser..
11/27/14
20140346340

Method and a mass spectrometer and uses thereof for detecting ions or subsequently-ionised neutral particles from samples


A method is used in a time-of-flight mass spectrometer for analysis of a first pulsed ion beam, the ions of which are disposed along the pulse direction, separated with respect to their ion masses. The ions of at least one individual predetermined ion mass or of at least one predetermined range of ion masses can be decoupled from the first pulsed ion beam, as at least one decoupled ion beam, and the first ion beam and the at least one decoupled ion beam are analyzed..
11/27/14
20140345522

High-energy ion implanter


A high-energy ion implanter includes: a beam generation unit that includes an ion source and a mass spectrometer; a radio frequency multi-stage linear acceleration unit; a deflection unit that includes a magnetic field type energy analysis device for filtering ions by a momentum; a beam transportation line unit; and a substrate processing/supplying unit. In this apparatus, an electric field type final energy filter that deflects a high-energy scan beam in the vertical direction by an electric field is inserted between the electric field type beam collimator and the wafer in addition to the magnetic field type mass spectrometer and the magnetic field type energy analysis device as momentum filters and the radio frequency multi-stage linear acceleration unit as a velocity filter..


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Mass Spectrometer topics: Mass Spectrometer, Spectrometer, Mass Spectrometry, Spectrometry, Downstream, Coordinates, Quantitative, Chromatograph, Data Processing, Biomolecule, Data Acquisition, Electrical Signal, Data Compression, Fragmentation, Irradiation

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