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Mass Spectrometer patents



      

This page is updated frequently with new Mass Spectrometer-related patent applications.




Date/App# patent app List of recent Mass Spectrometer-related patents
04/07/16
20160099136 
 Systems and methods for acquiring data for mass spectrometry images patent thumbnailSystems and methods for acquiring data for mass spectrometry images
Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.


04/07/16
20160097748 
 Autonomous ambient air sampling system for monitoring semi-volatile/non-volatile organic compounds patent thumbnailAutonomous ambient air sampling system for monitoring semi-volatile/non-volatile organic compounds
An automated ambient air sampling system and method for monitoring organic compounds that may provide continuous data, the system including a thermal desorption system, an injection port, a pre-concentration system, a gas chromatograph and an ion trap mass spectrometer, wherein an air sampling chamber may also function as a thermal desorption chamber.. .
Brigham Young University


03/31/16
20160093482 
 Modulation of instrument resolution dependant upon the complexity of a previous scan patent thumbnailModulation of instrument resolution dependant upon the complexity of a previous scan
Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor.
Dh Technologies Development Pte. Ltd.


03/31/16
20160093480 
 Compact mass spectrometer patent thumbnailCompact mass spectrometer
A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar.
Micromass Uk Limited


03/31/16
20160093479 
 Compact mass spectrometer patent thumbnailCompact mass spectrometer
A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber.
Micromass Uk Limited


03/31/16
20160091386 
 Sniffing leak detector having a nanoporous membrane patent thumbnailSniffing leak detector having a nanoporous membrane
A sniffing leak detector for sucking in and analyzing gas, including a sniffing probe for sucking in the gas, a gas-conveying pump connected to the sniffing probe, and a mass spectrometer connected to a vacuum pump for analyzing the sucked-in gas in a high vacuum. The gas flow through the sniffing probe is conducted along a membrane having gas-permeable pores.
Inficon Gmbh


03/24/16
20160086785 
 Methods and devices for generating double emulsions patent thumbnailMethods and devices for generating double emulsions
The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer.
University Of Washington Through Its Center For Commercialization


03/24/16
20160086784 
 Ionization chamber with temperature-controlled gas feed patent thumbnailIonization chamber with temperature-controlled gas feed
The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet.
Bruker Daltonik Gmbh


03/24/16
20160086782 
 Species detection using mass spectrometry patent thumbnailSpecies detection using mass spectrometry
Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (mrm) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079052 
 Method and  mass spectrometry patent thumbnailMethod and mass spectrometry
A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (mr tof) mass spectrometry..
Thermo Fisher Scientific (bremen) Gmbh


03/17/16
20160079050 

Mass spectrometry method, ion generator and mass spectrometry system


A mass spectrometry method includes a step of atomizing liquid including a sample using an ultrasonic transducer; a step of transferring the atomized liquid; a step of generating ions from the transferred liquid using a dart ion source; and a step of analyzing a mass spectrometry by introducing the generated ions into a mass spectrometer.. .
Bio Chromato, Inc.


03/17/16
20160079048 

Systems and methods for rapidly screening samples by mass spectrometry


Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079047 

Systems and methods for using variable mass selection window widths in tandem mass spectrometry


Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079046 

Multiple frequency rf amplifier, mass spectrometer including the same, and mass spectrometry mass spectrometer


Provided is a multiple frequency radio frequency (rf) amplifier. The multiple frequency rf amplifier includes a waveform generation circuit configured to generate an rf signal by amplitude and frequency-modulating a reference waveform signal, a drive amplifier circuit configured to drive-amplify the rf signal, and a power amplifier circuit configured to generate a multiple frequency rf voltage signal through a power amplification of the drive-amplified rf signal and output the multiple frequency rf voltage signal to an ion trap for a mass spectrometry..
Korea Basic Science Institute


03/10/16
20160071717 

Orthogonal acceleration system for time-of-flight mass spectrometer


An orthogonal pulse accelerator for a time-of-flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension.
Perkinelmer Health Sciences, Inc.


03/10/16
20160071716 

Maldi imaging and ion source


An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length≦300 mm.
Micromass Uk Limited


03/10/16
20160071713 

Ion implantation system and process for ultrasensitive determination of target isotopes


A system and process are disclosed for ultrasensitive determination of target isotopes of analytical interest in a sample. Target isotopes may be implanted in an implant area on a high-purity substrate to pre-concentrate the target isotopes free of contaminants.
Battelle Memorial Institute


03/10/16
20160071712 

Direct sample analysis device adapters and methods of using them


Certain embodiments described herein are directed to adapters for use in coupling a direct sample analysis device to an analytical instrument such as, for example, a mass spectrometer. In some examples, the adapter can include an internal coupler separated from an external coupler through an insulator..

03/10/16
20160071711 

Imaging mass spectrometric data processing method and imaging mass spectrometer


Compressed data of mass spectra obtained at respective measurement points and normalization coefficients for xic normalization or the like are stored in a memory (21). When a normalized imaging graphic at a specific m/z value is to be displayed, a data decompression processor (23) reads the minimally required set of compressed data from the memory (21) and restores the intensity value corresponding to the m/z value at each measurement point.
Shimadzu Corporation


03/10/16
20160069848 

Liquid chromatograph mass spectrometer


In a liquid chromatograph mass spectrometer (lc/ms) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional lc or similar lc with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the lc depending on the kind of column or other factors or the degree of ease of ionization in the ms. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information.
Shimadzu Corporation


03/03/16
20160064202 

Maldi-tof mass spectrometers with delay time variations and related methods


Maldi-tof ms systems have solid state lasers and successive and varied delay times between ionization and acceleration (e.g. Extraction) to change focus masses during a single sample signal acquisition without requiring tuning of the ms by a user.
Biomérieux, Inc.


02/25/16
20160056030 

System and delicate membrane condensed phase membrane introduction mass spectrometry (cp-mims)


Systems and methods for analyzing a sample comprising an analyte selected from a volatile organic compound, a semi-volatile organic compound, a non-volatile organic compound, a polar organic compound and a halogenated non-volatile organic compound are provided. The systems comprises an ionization source, a flow cell or an immersion probe with a delicate membrane, the flow cell or immersion probe for accepting the sample, and the delicate membrane interface in fluid communication with the ionization source and a mass spectrometer.

02/25/16
20160056029 

Apparatus and methods for an atmospheric sampling inlet for a portable mass spectrometer


Atmospheric sampling system designed to minimize cross-contamination between successive samples acquired by a portable, or handheld, mass spectrometer. Techniques to reduce the overall sample load on portable mass spectrometers having limited pumping capacity, such as capture pumps.
Bayspec, Inc.


02/25/16
20160054276 

Method for establishing shenqi fuzheng injection fingerprint spectrum


A method for establishing a shenqi fuzheng injection fingerprint spectrum, comprising: employing an ultra-high voltage liquid chromatography mass spectrometer to test the shenqi fuzheng injection, the chromatography conditions including: chromatographic column: agilent zorbax eclipse plus c18, 2.1 mm×100 mm, 1.8 μm; mobile phase: mobile phase a is 0.1% formic acid aqueous solution, and mobile phase b is 0.1% formic acid acetonitrile solution; employing gradient elution procedure as follows: 0-0.5 min, 95% of mobile phase a, and 5% of mobile phase b; 0.5-10 min, 95%-75% of mobile phase a, and 5%-25% of mobile phase b; 10-15 min, 75%-45% of mobile phase a, and 25%-55% of mobile phase b; 15-18 min, 45%-0% of mobile phase a, and 55%-100% of mobile phase b; and 18-20 min, 0% of mobile phase a, and 100% of mobile phase b.. .
Li Min Pharmaceutical Factory Of Livzon Pharmaceut Ical Group


02/25/16
20160054224 

Mass spectrometer detector using optically active membrane


A detector suitable for mass spectroscopy uses a thin membrane that converts the kinetic energy of impinging molecules into corresponding photons, the latter detected with a suitable photosensor. The arrival of molecules at the membrane is detected by detection of the corresponding photons..
Wisconsin Alumni Research Foundation


02/18/16
20160049286 

Abridged ion trap - time of flight mass spectrometer


An improved trap-tof mass spectrometer has a set of electrodes arranged to produce both a quadrupolar rf confining field and a substantially homogeneous dipole field. In operation, ions are first confined by the rf field and then, at a selected time, the rf confining field is discontinued and the dipole field is used to accelerate the ions so as to initiate a tof ms analysis.
Bruker Daltonics, Inc.


02/18/16
20160047782 

Mass spectrometry (ms) identification algorithm


A system includes a gas chromatograph configured to determine experimental chromatographic data including retention times associated with samples. The system also includes a mass spectrometer configured to determine experimental mass spectral data associated with samples.
Smiths Detection Inc.


02/11/16
20160042937 

Methods for predictive automatic gain control for hybrid mass spectrometers


A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer.. .
Thermo Finnigan Llc


02/11/16
20160042936 

Compact mass spectrometer


Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.


02/11/16
20160042934 

Lateral introduction of ions into rf ion guides


An ion guide system includes an ion guide with pole rods, a device for laterally introducing an ion species, and a mass spectrometer for analyzing product ions of reactions between different ion species. The device is configured and positioned such that an rf field with at least two-fold rotational symmetry with respect to the axis is generated.
Bruker Daltonik Gmbh


02/11/16
20160042933 

Removal of ions from survey scans using variable window band-pass filtering to improve intrascan dynamic range


Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer.
Dh Technologies Development Pte. Ltd.


02/11/16
20160042930 

Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


02/11/16
20160042929 

Mass spectrometer


A mass spectrometer including a memory unit storing information indicating combinations of precursor ions for cids in respective stages. If an ms1 spectrum on which cid is not performed is obtained during execution of an analysis, a precursor ion selector determines whether an ion registered as a precursor ion for the first-stage cid exists on the ms1 spectrum, based on the list held in the memory unit.
Shimadzu Corporation


02/04/16
20160035558 

Multi-reflecting mass spectrometer


To improve spatial and energy acceptance of multi-reflecting time-of-flight, open traps, and electrostatic trap analyzers, a novel ion mirror is disclosed. Incorporation of immersion lens between ion mirrors allows reaching the fifth order time per energy focusing simultaneously with the third order time per spatial focusing including energy-spatial cross terms.
Leco Corporation


02/04/16
20160035557 

Multi inlet for solvent assisted inlet ionisation


A mass spectrometer is disclosed comprising a dual channel solvent assisted inlet ionisation (“saii”) interface.. .
Micromass Uk Limited


02/04/16
20160035554 

Aperture gas flow restriction


A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture.
Micromass Uk Limited


02/04/16
20160035552 

Method and system for tandem mass spectrometry


A method of data independent ms-ms analysis is disclosed. The method comprises ramping or stepping in small steps of a wide (at least 10 amu) parent mass window in a first parent selecting mass spectrometer (ms1), arranging rapid ion transfer through a collisional cell, either by axial gas flow or by an axial dc field or by a travelling rf wave, frequently pulsing an orthogonal accelerator with a string of time-encoded pulses, analyzing fragment ions in a multi-reflecting time-flight mass spectrometer, acquiring data in a data logging format, and decoding signal strings corresponding to the entire scan of parent masses, such that fragment spectra are formed based on time correlation between fragment and parent masses.
Leco Corporation


02/04/16
20160035550 

Plasma cleaning for mass spectrometers


A mass spectrometry (ms) system may be cleaned by generating plasma and contacting an internal surface of the system to be cleaned with the plasma. The system may be switched between operating in an analytical mode and in a cleaning mode.
Agilent Technologies, Inc.


02/04/16
20160035549 

Hybrid mass spectrometer and methods of operating a mass spectrometer


A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list.
Thermo Finnigan Llc


02/04/16
20160033456 

Gaseous mercury detection systems, calibration systems, and related methods


Embodiments disclosed herein are directed to gaseous mercury detection systems, calibration systems, and related methods. The gaseous mercury detection systems are configured to detect gas-phase mercury-compounds present in ambient air.
Utah State University


01/28/16
20160029472 

Plasma generator using dielectric resonator


A dielectric resonator is excited at its natural resonant frequency to produce highly uniform electric field for the generation of plasma. The plasma may be used optical or mass spectrometer..
Radom Corporation


01/28/16
20160027633 

Collision cell multipole


mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion.
Thermo Fisher Scientific (bremen) Gmbh


01/28/16
20160027629 

Apparatus for elemental analysis of particles by mass spectrometry


A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
Fluidigm Canada Inc.


01/28/16
20160025656 

Microwave plasma spectrometer using dielectric resonator


A dielectric resonator is excited at its natural resonant frequency to produce a highly uniform electric field for the generation of plasma. The plasma may be used as a desolvator, atomizer excitation source and ionization source in an optical spectrometer or a mass spectrometer..
Radom Corporation


01/21/16
20160020082 

Mass spectrometer system and method


An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage u, an amplitude v of a radio-frequency voltage, and a frequency f of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger.
Hitachi High-technologies Corporation


01/21/16
20160020081 

Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer


Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows msn experiments to be performed on very basic mass spectrometers, even those without secondary mass analyzers and/or collision cells.
Wisconsin Alumni Research Foundation


01/21/16
20160020080 

Sample plate for maldi-tof mass spectrometer and manufacturing the sample plate and mass spectrometry method using the sample plate


The present invention relates to a sample plate to be used for a maldi-tof (matrix assisted laser desorption ionization time of flight) mass spectrometer, and more particularly, to a sample plate for a maldi-tof mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a maldi-tof mass spectrometer so as to overcome the limits of the gas chromatography method of the related art.
Industry-academic Cooperation Foundation, Yonsei University


01/21/16
20160018410 

Deep maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof


A method of analyzing a biological sample, for example serum or other blood-based samples, using a maldi-tof mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a maldi-tof sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument.
Biodesix, Inc.


01/21/16
20160018361 

System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry


An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges.

01/14/16
20160013040 

Ion trap mass spectrometer


An ion trap mass spectrometer including an ion trap analyzer, an ion packet injector, and an ion detector is disclosed, along with a method of mass spectrometry. The ion packet injector injects packets of ions into a field of the ion trap analyzer.
Leco Corporation


01/14/16
20160013038 

Use of mass spectral difference networks for determining charge state, adduction, neutral loss and polymerization


A mass spectrometric analysis method comprises: (1) processing a mass spectrum to reduce the signals to monoisotopic values; (2) creating a list of differences between the monoisotopic values; (3) creating one or more lists of theoretical mass-to-charge differences among known adducts, charge states and polymerization states whose formation may be expected from various analyte molecules; (4) comparing the theoretical differences (line or edge in the network) to the list of differences from the mass spectrum and, where applicable, make and tabulate tentative species assignments; (5) assigning the mass spectral peaks to respective ion species in accordance with the redundancy of each assignment based on multiple independent calculated mass-to-charge differences pertaining to each peak; (6) choosing an ion species for further fragmentation or reaction in the mass spectrometer, based on the assigning; and (7) performing the fragmentation or reaction on the chosen ion species in the mass spectrometer.. .
Thermo Finnigan Llc


01/14/16
20160013036 

Improved lock component corrections


A method of mass spectrometry is disclosed comprising initially calibrating or recalibrating a mass spectrometer at a time t0 and at the same time measuring a time of flight or mass to charge ratio m0 of one or more lockmass ions. The mass spectrometer is then operated at a subsequent time t1 and the time of flight or mass to charge ratio m1 of the one or more lockmass ions is measured at subsequent time t1.
Micromass Uk Limited


01/07/16
20160005587 

Ion trap mass spectrometer


An electrostatic analyzer including at least one first set of electrodes, at least one second set of electrodes, and a field free space separating the two sets of electrodes is disclosed. The two sets of electrodes form two-dimensional electrostatic fields of ion mirrors and are arranged to provide isochronous ion oscillations in an x-y plane.
Leco Corporation


01/07/16
20160005586 

Differentially pumped dual linear quadrupole ion trap mass spectrometer


The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (lqit) mass spectrometers with differentially pumped vacuum chambers..
Purdue Research Foundation


01/07/16
20160005585 

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction, the x direction being orthogonal to y, characterized in that the mirrors are not a constant distance from each other in the x direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer.
Thermo Fisher Scientific (bremen) Gmbh


01/07/16
20160005584 

Ion trap mass spectrometer


An electrostatic mass spectrometer and a method of mass spectrometric analysis utilizing novel traps are disclosed. The mass spectrometer includes an ion source, an ion pulse injector, an ion detector, a set of analyzer electrodes connected to a set of power supplies, and a vacuum chamber enclosing the set of analyzer electrodes.
Leco Corporation


01/07/16
20160005583 

Reflectors for time-of-flight mass spectrometers


The invention relates to reflectors for time-of-flight mass spectrometers, and especially their design. A mamyrin reflector is provided which consists of metal plates with cut-out internal apertures, and symmetric shielding edges which are set back from the inner edges.
Bruker Daltonik Gmbh


01/07/16
20160005582 

Ion trap mass spectrometer


A mass spectrometer including an ion source, an ion guide, a pulsed converter, and an electrostatic analyzer is disclosed, along with a method of mass spectrometry and an ion injector. The ion source generates ions, such as ions within a continuous or a quasi-continuous ion beam.
Leco Corporation


01/07/16
20160005581 

Multiple ion gate method and apparatus


A second gate in an ion mobility spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the ion mobility mass spectrometer is used to modulate peak intensities in the ims spectrum, allowing each peak in the ims spectrum to be unambiguously matched with its set of fragment ions in a subsequent ms-ms mass spectrum..

01/07/16
20160005580 

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction and having a space therebetween, the x direction being orthogonal to y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the x direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length..
Thermo Fisher Scientific (bremen) Gmbh


01/07/16
20160005578 

Parallel elemental and molecular mass spectrometry analysis with laser ablation sampling


An apparatus for mass spectrometry includes a laser ablation sampler comprising a laser ablation chamber and a laser which produces a laser beam. The laser irradiates and ablates a material from a sample placed within the laser ablation chamber so as to generate an ablated sample material.
Westfaelische Wilhelms-universitaet Muenster


01/07/16
20160003787 

Method and system for monitoring biomolecule separations by mass spectrometry


Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column.
Microsaic Systems Plc


12/31/15
20150380233 

Ion trap mass spectrometer


A novel ms-ms apparatus utilizing electrostatic traps is disclosed, along with an associated method of analysis. The apparatus may include a chromatograph, an ion source, a first mass spectrometer, a fragmentation cell, an ion guide, a pulsed converter, and a z-directional elongated electrostatic trap.
Leco Corporation


12/31/15
20150380232 

Device allowing improved reaction monitoring of gas phase reactions in mass spectrometers using an auto ejection ion trap


A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. A second device is arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the collision or reaction region.
Micromass Uk Limited


12/31/15
20150380231 

Improved efficiency and precise control of gas phase reactions in mass spectrometers using an auto ejection ion trap


A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. The collision or reaction device further comprises a second device arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the first device without causing the first ions to be substantially ejected from the first device..
Micromass Uk Limited


12/31/15
20150380229 

Mass spectrometer


A mass spectrometer (1) is provided with: an ionization chamber (10) for ionizing a sample (s) on its surface at an analysis point through irradiation by a laser beam; an analysis chamber (23) having a mass spectroscope (24) for detecting ions; a middle vacuum chamber (21, 22) arranged between the ionization chamber (10) and the analysis chamber (23); and an introduction pipe (12) or an introduction hole for allowing the inside of the housing (11) of the ionization chamber (10) to communicate with the inside of the middle vacuum chamber (21), wherein ions and fine particles, which have not been drawn into the introduction pipe (12) or introduction hole, can be prevented from spreading inside of the chamber. The structure of the mass spectrometer (1) further includes: an exhaust pipe (13); and a fan (15) for drawing air into the exhaust pipe (13) so that air that contains ions and/or fine particles, which have not been introduced into the introduction pipe (12) or introduction hole, can be suctioned up into the exhaust pipe (13) when the fan (15) is in operation..
Shimadzu Corporation


12/31/15
20150380226 

Ionization chamber


An ionization chamber 100 is provided between a liquid chromatograph unit 60 and a mass spectrometer 50, and is formed of: an atomization means 15; and an ion introducing pipe 19 of which the entrance portion is created within the ionization chamber 100 in the horizontal direction that is perpendicular to the z direction and of which the exit portion is created within the mass spectrometer unit 50. A liquid sample that has been fed from the liquid chromatograph unit 60 is sprayed in the z direction by the atomization means 15 while being ionized within the ionization chamber 100, wherein the entrance portion has an opening in such a form that corresponds to the spread in the xy plane of the liquid sample sprayed in the z direction.
Shimadzu Corporation


12/24/15
20150371840 

Ion injection device for a time-of-flight mass spectrometer


The invention provides methods and devices to pulse ions from an rf ion storage into the flight tube of a time-of-flight mass spectrometer. The pusher cell comprises essentially two parallel plates, both plates completely slotted into two electrically insulated halves.
Bruker Daltonics, Inc.


12/24/15
20150371836 

Saturation correction for ion signals in time-of-flight mass spectrometers


The invention relates to time-of-flight mass spectrometers in which individual time-of-flight spectra are measured by detection systems with limited dynamic measurement range and are summed to sum spectra. The invention proposes a method to increase the dynamic range of measurement of the spectrum.
Bruker Daltonik Gmbh


12/24/15
20150369782 

Chromatograph/mass spectrometer data processing device


If multiple polyvalent ion peak candidates with different valences surmised to be derived from the target compound have been obtained, a mass chromatogram in the vicinity of the retention time of the target compound at the mass-charge ratio m/z of each polyvalent ion peak candidate is generated, and these are overlaid and displayed on the display screen. If the polyvalent ions are derived from the same compound, peaks of similar shape having a peak top near the retention time should appear in multiple mass chromatograms.
Shimadzu Corporation


12/17/15
20150364314 

Off-axis channel in electrospray ionization for removal of particulate matter


The present invention relates to electrospray ionization (esi) at atmospheric pressure coupled with a mass spectrometer, in particular to a special kind of micro-electrospray with liquid flows in the range of 0.1 to 100 microliters per minute. The invention describes the use of an off-axis pre-entrance channel in an esi ion source to prevent particulate matter with higher inertia than the (charged) gas molecules, such as droplets, from entering the mass spectrometer.
Bruker Daltonics, Inc.


12/17/15
20150364308 

Collision cell


A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis.
Thermo Fisher Scientific (bremen) Gmbh


12/17/15
20150364304 

Methods for acquiring and evaluating mass spectra in fourier transform mass spectrometers


The invention provides a method for acquiring a mass spectrum with a fourier transform mass spectrometer, wherein analyte ions and additional reporter ions oscillate at mass specific frequencies in a measuring cell of the frequency mass spectrometer and interact by coulomb forces; the image current signal induced by the reporter ion is measured; and mass signals of the analyte ions are determined from a sideband signal of the reporter ions in the frequency domain or from the instantaneous frequency of the reporter ions in the time domain.. .
Bruker Daltonik Gmbh


12/17/15
20150364303 

Methods of operating a fourier transform mass analyzer


A method is disclosed for operating a mass spectrometer having a fourier transform (ft) analyzer, such as an orbital electrostatic trap mass analyzer, to avoid peak coalescence and/or other phenomena arising from frequency-shifting caused by ion-ion interactions. Ions of a first group are mass analyzed, for example in a quadrupole ion trap analyzer, to generate a mass spectrum.
Thermo Finnigan Llc


12/17/15
20150362461 

System comprising a mass spectrometer coupled to a faims apparatus and methods of operation


A method of operating a system comprising a chromatograph and a mass spectrometer comprises: (a) providing an abundance threshold and a list comprising respective entries for precursor ion species of interest comprising respective precursor-ion m/z ratios; (b) transmitting a first sample fraction portion comprising a plurality of sample-fraction ion species through an ion mobility spectrometer operated in non-dispersive mode to the mass spectrometer; (c) detecting a respective abundance at each of a plurality of sample-fraction m/z ratios; and (d) upon detection of an above-threshold ion abundance at an m/z-ratio corresponding to a first precursor ion species of interest: (d1) inletting a second sample fraction portion into the ion mobility spectrometer operated in dispersive mode such that ions of the first precursor-ion species are preferentially transmitted therethrough; (d2) fragmenting the preferentially-transmitted ions so as to generate product ion species; and (d3) detecting the product ion species.. .
Thermo Finnigan Llc


12/10/15
20150357176 

Mass analysis device and mass separation device


A mass spectrometer (10) is configured from an ion source (1), an ion introduction unit (2), a mass analyzer (3), an ion detection unit (4), and the like. Crude ions are introduced into a separation space (5) at a predetermined acceleration voltage as a pulse synchronized with the phase of a one-dimensional high-frequency electric field.

12/10/15
20150357175 

Mass spectrometer with improved magnetic sector


The present invention relates to a compact and portable mass spectrometer device comprising a source of ions, a non-scanning magnetic sector for separating ions originating at the source of ions according to their mass-to-charge ratios, and a detection means. The magnetic sector comprises an ion entrance plane and at least two ion exit planes, which allow to optimize the resolving power of the mass spectrometer for specific mass-to charge ratio sub-ranges..
Luxembourg Institute Of Science And Technology (list)


12/10/15
20150357173 

Laser ablation atmospheric pressure ionization mass spectrometry


In an embodiment, the present invention provides an apparatus for mass spectrometry which includes a laser ablation sampler comprising a laser ablation chamber and a laser. The laser ablation chamber is configured so that the laser can irradiate and ablate a material from a sample to generate an ablated sample material.
WestfÄlische Wilhelms-universitÄt MÜnster


12/10/15
20150355155 

Method of measuring dissolved methane in seawater


Provided is a method of measuring dissolved methane in seawater, including: a) injecting a sample into a vacuum container containing a cadmium chloride solution injected thereinto and refrigerating the vacuum container; b) shaking the vacuum container, and achieving temperature equilibrium with an ambient temperature; c) separating the dissolved methane from residue by passing the sample in the vacuum container through a methane separator; and d) analyzing the separated dissolved methane by a mass spectrometer. According to the method of measuring dissolved methane in seawater of the present invention, a recovery rate of dissolved methane may be maximally increased to improve an analysis rate accordingly, and an analysis of dissolved methane may be conducted even with a small amount of sample, and in addition to the measurement of the dissolved methane, a sulfur isotope analysis may be simultaneously conducted by using a sample from which the dissolved methane is extracted..
Korea Institute Of Geoscience And Mineral Resources


12/10/15
20150355148 

Interfacing capillary electrophoresis to a mass spectrometer via an impactor spray ionization source


A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a capillary electrophoresis (“ce”) separation device.
Micromass Uk Limited


12/03/15
20150348770 

Mass spectrometer with optimized magnetic shunt


The present invention relates to a mass spectrometer device comprising a source of ions, an electrostatic sector, a non-scanning magnetic sector arranged downstream of the electrostatic sector, for separating ions originating at the source of ions according to their mass-to-charge ratios, and a detection means. A magnetic shunt is arranged in the drift space between the electrostatic sector and the magnetic sector.
Luxemburg Institute Of Science And Technology (lis


12/03/15
20150346214 

Detection of membrane proteins


According to the present invention, there is provided a method of detecting a membrane protein by mass spectrometry, the method comprising the steps of: (a) providing a solution comprising a detergent micelle in which said membrane protein is contained, wherein said solution contains a polyoxyalkylene glycol detergent; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the micelle; (d) ionising the membrane protein; (e) resolving the ionised membrane protein using the mass analyser; and (f) detecting the resolved membrane protein using the detector. Also provided are reagents for use in said method..

12/03/15
20150346186 

Integrated disease diagnostic system using matrix-assisted laser desorption/ionization time-of-flight mass spectrometer


A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (maldi-tof ms) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness.
Asta, Co. Ltd.


11/26/15
20150340219 

Integrated sample processing for electrospray ionization devices


Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one esi emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one esi emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one esi emitter thereby preferentially directing analyte molecules out of the at least one esi emitter.
The University Of North Carolina At Chapel Hill


11/26/15
20150340217 

Targeted analysis for tandem mass spectrometry


A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection tof device that separates ions into packets in accordance with their m/z.
Thermo Fisher Scientific (bremen) Gmbh


11/26/15
20150340215 

Diathermy knife ionisation source


A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife.
Micromass Uk Limited


11/26/15
20150340214 

Chemical sampling and detection methods and apparatus


This invention describes a sample collection and desorption device and method that collects residues of explosives and other chemicals from a surface and then introduces them into a detector. The desorption method and device include introducing additional chemicals while heating up the sample collector, thus, the collected sample may be converted via a chemical reaction or a catalytic process.

11/26/15
20150340212 

Tandem quadrupole mass spectrometer


A dwell time calculation table (51a) showing a correspondence relation between a cid gas pressure inside a collision cell (31) and a dwell time for data collection is stored in a processing condition parameter memory (51) of a controller (50). In the table (51a), as the cid gas pressure becomes higher, the dwell time becomes longer.
Shimadzu Corporation


11/26/15
20150337386 

Test composition for screening cancers


Provided in the present invention are a molecule for biomarking cancers and a test composition for screening cancers and a detection method thereof comprising designing a number of oligonucleotide primers or probes by analyzing specimens for methylated regions of targeted genes pax1, znf582, sox1 and nkx6-1 in physical examination, and then using the oligonucleotide probes to detect whether methylation exists in the target genes, and further judge the likelihood of the occurrence of cancer. The detection methods for methylation status include methylation-specific pcr, (msp), quantitative methylation-specific pcr (qmsp), bisulfate sequencing (bs), microarrays, mass spectrometer, denaturing high-performance liquid chromatography (dhplc), pyrosequencing, and enzyme-linked immunosorbent assay (elisa)..
Istat Biomedical Co., Ltd.


11/19/15
20150332904 

Parsing events during ms3 experiments


Systems and methods are provided for reducing the time period of a cid event of an ms3 experiment and making the overall fragmentation event more generic. A cid event of an ms3 experiment performed on a sample by a mass spectrometer is divided into two time periods using a processor.
Dh Technologies Development Pte. Ltd.


11/12/15
20150325424 

Method of assessing vacuum conditions in a mass spectrometer


A method is proposed for assessing the vacuum conditions in a mass spectrometer (10) such as an ion cyclotron resonance or orbital trapping mass spectrometer. Such mass spectrometers generate a transient detection signal resulting from ions of one or species in an ion trap (80).
Thermo Fisher Scientific (bremen) Gmbh


11/12/15
20150325421 

Droplet manipulation using gas-phase standing-wave ultrasound fields in ms sources


An ion source for a mass spectrometer is disclosed comprising an ionisation device which emits a stream of droplets and one or more ultrasonic transmitters which create one or more acoustic standing waves. The acoustic standing waves may be used to further nebulise the stream of droplets and induce internal mixing of the droplets..
Micromass Uk Limited


11/05/15
20150318162 

Segmented planar calibration for correction of errors in time of flight mass spectrometers


An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions.
Micromass Uk Limited


11/05/15
20150318161 

High pressure mass spectrometry systems and methods


Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.


11/05/15
20150318160 

Probe for extraction of molecules of interest from a sample


A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer.

11/05/15
20150318159 

Systems and methods for detection and quantification of selenium and silicon in samples


The present disclosure provides methods and systems for improved detection and/or quantification of selenium (se) and/or silicon (si) in samples. In certain embodiment, the methods and systems feature the use of carbon dioxide (co2) as a reaction gas in a reaction cell chamber, such as a dynamic reaction cell (drc), of an inductively coupled plasma mass spectrometer (icp-ms).
Perkinelmer Health Sciences, Inc.


11/05/15
20150318158 

Probe for extraction of molecules of interest from a sample


The present disclosure describes a device for generating ionized molecules for analysis in a mass spectrometer. The device includes: a mesh substrate coated with an extraction phase, the extraction phase comprising a polymer that absorbs a molecule of interest from a matrix, or a polymer and solid phase microextraction (spme) particles having pores dimensioned to absorb a molecule of interest from a matrix, where the mesh substrate has a sufficiently open structure to allow fluid to flow through the mesh substrate; and a solid substrate connected to the mesh substrate to provide stability to the coated mesh substrate.

11/05/15
20150318156 

Ion optical elements


Ion optics devices and related methods of making and using the same are disclosed herein that generally involve forming a plurality of electrode structures on a single substrate. An aspect ratio of the structures relative to a plurality of recesses which separate the structures can be selected so as to substantially prevent ions passing through the finished device from contacting exposed, electrically-insulating portions of the substrate.
Dh Technologies Development Pte. Ltd.


11/05/15
20150318155 

Method and improving ion transmission into a mass spectrometer


An ion transfer device for transferring ions emerging from an electrospray ion source at atmosphere to a vacuum chamber includes an inner surface in the shape of a diverging conical duct. The ion transfer device has an entrance aperture for positioning proximate the exit port of the electrospray ion source emitter, the entrance aperture receiving the electrosprayed ions from the exit port of the electrospray ion source emitter at atmosphere, the diverging conical duct being an electrode toward which the ions migrate and having an exit aperture with an inner diameter larger than an inner diameter of its entrance aperture, the exit aperture enclosed in the vacuum chamber, the diverging conical duct transporting the ions from atmosphere to vacuum.
The Rockefeller University


11/05/15
20150318154 

Scheduled ms3 for quantitation


Systems and methods are provided for scheduled ms3. A compound of interest is separated from a sample over a known time period using a separation device.
Dh Technologies Development Pte. Ltd.




Mass Spectrometer topics: Mass Spectrometer, Spectrometer, Mass Spectrometry, Spectrometry, Downstream, Coordinates, Quantitative, Chromatograph, Data Processing, Biomolecule, Data Acquisition, Electrical Signal, Data Compression, Fragmentation, Irradiation

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