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Mass Spectrometer patents



      

This page is updated frequently with new Mass Spectrometer-related patent applications.




Date/App# patent app List of recent Mass Spectrometer-related patents
06/23/16
20160181081 
 Multi-element isotopic measurement by direct coupling of a multi-cycle isotachophoresis technique and a mass spectrometry technique patent thumbnailMulti-element isotopic measurement by direct coupling of a multi-cycle isotachophoresis technique and a mass spectrometry technique
A method for separating electrically charged species contained in a solution by an isotachophoresis method applied in an electrophoresis device, the isotachophoresis method being coupled to isotopic measurement using a mass spectrometer. The method notably comprises a step of stopping the voltage applied to the terminal of the electrophoresis capillary and transient application of a counter-pressure making it possible to utilize the length of the capillary several times and extend the separation distance artificially..

06/23/16
20160181079 
 Mass spectrometer inlet with reduced average flow patent thumbnailMass spectrometer inlet with reduced average flow
An interface configured to transfer ions produced at or near atmospheric pressure conditions into a mass spectrometer for mass analysis is provided. The interface includes a first conduit including an inlet configured to receive a fluid containing the ions and an outlet configured to direct the fluid containing the ions into the mass spectrometer.

06/23/16
20160181078 
 Bubble removal from liquid flow into a mass spectrometer source patent thumbnailBubble removal from liquid flow into a mass spectrometer source
Methods and systems for delivering a liquid sample to an ion source are provided herein. In various aspects, the methods and systems can improve the stability of a flow of liquid sample delivered to an ion source.

06/23/16
20160181077 
 Sample quantitation with a miniature mass spectrometer patent thumbnailSample quantitation with a miniature mass spectrometer
The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte.

06/23/16
20160181076 
 Tuning a mass spectrometer using optimization patent thumbnailTuning a mass spectrometer using optimization
Systems, methods, and apparatuses are provided for tuning a mass spectrometer. An optimization process can be performed to determine optimal parameters for various physical parameters of elements of the mass spectrometer.

06/23/16
20160178602 
 Analytical  detecting fuel markers patent thumbnailAnalytical detecting fuel markers
A gas chromatographic method for detecting a first marker and a second marker in a fuel in two channels: (i) a first capillary column coated with polysiloxane and a second capillary column coated with polyethylene glycol; and (ii) a third capillary column coated with polymethylphenylsiloxane and a fourth deactivated capillary column. The steps are: (a) introducing a first sample into the first column to produce a first effluent; (b) introducing only a portion of the first effluent into the second column to produce a second effluent; (c) allowing the second effluent to pass through a mass spectrometer; (d) introducing a second sample into the third column to produce a third effluent; (e) introducing only a portion of the third effluent into the fourth column to produce a fourth effluent; (f) allowing the fourth effluent to pass through a mass spectrometer..

06/16/16
20160172180 
 Methods, apparatus, and system for mass spectrometry patent thumbnailMethods, apparatus, and system for mass spectrometry
A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments.
The Massachusetts Institute Of Technology


06/16/16
20160172177 
 Intermittent mass spectrometer inlet patent thumbnailIntermittent mass spectrometer inlet
An intermittent sample inlet device and methods for use of the intermittent sample inlet device are described that include an orifice plate with an entrance orifice and a rotating skimmer with a skimmer orifice, where the rotating skimmer is disposed between the orifice plate and a vacuum chamber wall. The rotating skimmer rotates so that the skimmer orifice intermittently aligns with the entrance orifice and allows an ion sample to pass through to a mass analyzer..
Smiths Detection Inc.


06/16/16
20160172173 
 Cascaded-signal-intensifier-based ion imaging detector for mass spectrometer patent thumbnailCascaded-signal-intensifier-based ion imaging detector for mass spectrometer
A detector system for a mass spectrometer comprises: a metal channel dynode (mcd) comprising at least one perforated metal plate configured to receive the exiting ions and eject electrons in response; a plurality of electron-to-photon converters arranged in a parallel stacked configuration, each such converter comprising a substrate plate having a phosphor coating on a first face; and an electrode film disposed on the phosphor coating; at least one photocathode, each of the at least one photocathode disposed between a respective pair of the plurality of electron-to-photon converters; an optical detector optically coupled a last one of the electron-to-photon converters; and at least one direct current power supply configured to apply, in operation, a respective bias electrical potential to the mcd and each of the electrode films and photocathodes.. .
Thermo Finnigan Llc


06/16/16
20160172172 
 High-voltage power unit and mass spectrometer using the power unit patent thumbnailHigh-voltage power unit and mass spectrometer using the power unit
An excessive overshoot preventing unit (16) is connected to a loop in which a command voltage vf according to a difference between: a voltage obtained by dividing an output voltage vout as a high voltage; and a control voltage v cont set from the outside is obtained and fed back to each of drive circuits (3 and 5) of a positive voltage generating unit (2) and a negative voltage generating unit (4). The excessive overshoot preventing unit (16) clamps the command voltage vf at a voltage value according to the control voltage vcont.
Shimadzu Corporation


06/16/16
20160172090 

Adjustment mechanism


A magnetic adjustment mechanism 100 comprising a chamber 10, an element 12 pivotally mounted within the chamber 10 and comprising a magnetic portion 14, and a magnetic actuator 18 arranged outside the chamber 10 to allow magnetic coupling with the magnetic portion 14 of the element 12 such that movement of the magnetic actuator 18 causes an adjustment of the position of the element 12. The adjustment mechanism 100 may be used within a vacuum chamber of a mass spectrometer to control the position of a moveable element from outside the chamber..
Thermo Fisher Scientific (bremen) Gmbh


06/16/16
20160169845 

Mass spectrometer


The objective of the present invention is to improve the robustness, sensitivity, and maintainability of a mass spectrometer to which a liquid chromatograph can be connected. This mass spectrometer includes: an ion source; a mass spectrometry unit; a plurality of flat plates used as electrodes having openings through which ions can be introduced to the mass spectrometer from an orthogonal direction along an ion introduction axis; a porous member provided between the mass spectrometry unit and the plurality of flat plates; and a mechanism for feeding gas to the plurality of flat plates for the side opposite from the ion introduction direction; the plurality of flat plates being disposed under atmospheric pressure, and the plurality of electrodes being set at a temperature higher than room temperature..
Hitachi High-technologies Corportion


06/16/16
20160169837 

Mass spectrometer


A closed-loop ion guide 1 is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. Ions are injected into the closed-loop ion guide 1 and may make several circuits of the closed-loop ion guide 1 before being ejected from the ion guide 1.
Micromass Uk Limited


06/09/16
20160163530 

Systems for separating ions and neutrals and methods of operating the same


A mass spectrometer system includes a pulsed ion source configured to generate ionized molecules and neutral molecules. The system also includes a first enclosure coupled in flow communication with the pulsed ion source.
Morpho Detection, Llc


06/09/16
20160163529 

Frequency scan linear ion trap mass spectrometry


An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an rf frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the rf to x and y electrodes.. .
Academia Sinica


06/09/16
20160163528 

Interface for an atmospheric pressure ion source in a mass spectrometer


The invention relates to a mass spectrometer having an ion source region at substantially atmospheric pressure in which ions are formed from a liquid sample. The mass spectrometer further has an interface for transmitting the formed ions from the ion source region into a vacuum region which is held at a pressure level substantially below the atmospheric pressure and where the formed ions are further processed.
Bruker Daltonics, Inc.


06/09/16
20160163527 

Ionizer and mass spectrometer


In the ionizer of the present invention, a stream of gas spouted from a nozzle (18) of a dart ionization unit (10) vaporizes and ionizes the components in a sample (25). Gaseous sample-component molecules which have not been ionized by that process are subsequently ionized by a reaction with a reactant ion produced by a corona discharge generated from a needle electrode (20).
Public University Corporation Yokohama City Univer Sity


06/09/16
20160163526 

Mass spectrometer


A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider.
Micromass Uk Limited


06/09/16
20160163525 

Mass spectrometer device and method using scanned phase applied potentials in ion guidance


An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser.
Micromass Uk Limited


06/09/16
20160163524 

Zero voltage mass spectrometry probes and systems


The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer).
Purdue Research Foundation


06/09/16
20160161404 

System using laser-scatter measurement instrument for organism identification and related network


An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples.
Bacterioscan Ltd


06/09/16
20160160641 

On-site mass spectrometry for liquid and extracted gas analysis of drilling fluids


An example method for analyzing drilling fluid used in a drilling operation within a subterranean formation may include receiving a drilling fluid sample from a flow of drilling fluid at a surface of the subterranean formation. A chemical composition of the drilling fluid sample may be determined using a mass spectrometer.
Halliburton Energy Services, Inc.


06/02/16
20160155624 

Multi-reflecting mass spectrometer with high throughput


Method and embodiments are provided for tandem mass spectrometer designed for extremely large charge throughput up to 1e+10 ion/sec. In one operation mode, the initial ion flow with wide m/z range is time separated in a trap array.
Leco Corporation


06/02/16
20160153944 

Ring shaped counter electrode to improve beam stability and compound sensitivity on a ceramic tile type microfluidic device


An interface for a mass spectrometer is disclosed comprising a microfluidic substrate, tile or cartridge 1 comprising a liquid chromatography separation column and an electrospray emitter 2. A counter electrode 4 is arranged downstream of a tip of the electrospray emitter 2 and is arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture 5 of a mass spectrometer..
Micromass Uk Limited


06/02/16
20160153060 

Method for species identification by using molecular weights of nucleic acid cleavage fragments


A method for species identification by using molecular weights of nucleic acid cleavage fragments, comprising steps of: performing a polymerase chain reaction and a nucleic acid cleavage reaction to cleave the nucleic acid sequence of the to-be-identified species into multiple nucleic acid cleavage fragments having different molecular weights; measuring the molecular weights of the nucleic acid cleavage fragments by using a mass spectrometer; comparing the molecular weight of each nucleic acid cleavage fragments of the to-be-identified species with molecular weights of nucleic acid cleavage fragments of a known species in a database; determining a number n of the identical nucleic acid cleavage fragments between the two species; and calculating a ratio n/m of the number n to the total number m of the nucleic acid cleavage fragments of the known species, wherein the ratio n/m represents similarity between the to-be-identified species and the known species.. .
Tech-knowhow Corp.


05/26/16
20160148796 

Constraining arcuate divergence in an ion mirror mass analyser


A charged particle analyzer apparatus comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner, whereby when the electrode systems are electrically biased the mirrors create an electrical field comprising opposing electrical fields along z; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyzer whilst the beam orbits around the axis z, the analyzer further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces. A mass spectrometer system comprising a plurality of the charged particle analyzers arranged as a parallel array..
Thermo Fisher Scientific (bremen) Gmbh


05/26/16
20160148795 

Time-of-flight mass spectrometers with cassini reflector


The invention relates to embodiments of high-resolution time-of-flight (tof) mass spectrometers with special reflectors. The invention provides reflectors with ideal energy and solid angle focusing, based on cassini ion traps, and proposes that a section of the flight path of the tof mass spectrometers takes the form of a cassini reflector.
Bruker Daltonik Gmbh


05/26/16
20160148792 

Mass spectrometer with bypass of a fragmentation device


A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer..
Micromass Uk Limited


05/26/16
20160146796 

High sensitivity quantitation of peptides by mass spectrometry


The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels).
Anderson Forschung Group, Inc.


05/19/16
20160141167 

Collision cell


A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis.
Thermo Fisher Scientific (bremen) Gmbh


05/12/16
20160133448 

Systems and methods for calibrating gain in an electron multiplier


Method for operating a mass spectrometer includes supplying a quantity of ions to an ion detector. The ion detector can include a conversion dynode operating in a first polarity and an electron multiplier.
Thermo Finnigan Llc


05/12/16
20160131626 

Methods for tracing fluid migration


The disclosure relates to application of a signature elemental tracer referred to herein as a signature). It comprises a selection of a small amount of a unique combination of a non-radioactive isotope or variant of a particular element or elements with stable isotopes, different from the natural-occurring combination of the elements in question.
New Century Financial Capital, Llc


05/05/16
20160126073 

Pathology interface system for mass spectrometry


A diagnostic system and method that includes a non-transitory computer readable medium storing machine executable instructions executable by the processor for altering tissue images, the instructions that further includes an input interface configured to receive a plurality of tissue images, the input interface generating enhanced resolution images from the plurality of tissue images for viewing, an annotation interface for positioning coordinates of interest on the enhanced resolution images, and a matrix model configured to evaluate the coordinates of interest on the enhanced resolutions to generate discrete coordinates, the matrix model using the discrete coordinates in performing mass spectrometer analysis to form at least one viewing image. The system also includes a user interface configured to provide at least one viewing image to a user at the display..
Vanderbilt University


05/05/16
20160123936 

Versatile ambient ionization-based interface for lc/ms


An apparatus (10) for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (16), which defines a flow passage (18) and is configured to supply the liquid sample. The fluid conduit (16) has an outer surface and a micro-hole (30) through the outer surface into the flow passage (18).
Ohio University


04/28/16
20160118238 

Compact mass spectrometer


A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar.
Micromass Uk Limited


04/28/16
20160118235 

Mass spectrometer


In a pause time assigned for switching voltage applied to a quadrupole mass filter or other ion transport optical system so as to switch the mass-to-charge ratio of a target ion in an sim measurement, the polarity of direct-current voltage applied to a pre-quadrupole mass filter is temporarily reversed. The voltage polarity reversal time is changed according to length of the pause time so that the ion intensity can sufficiently rise by the time the next dwell time begins.
Shimadzu Corporation


04/28/16
20160118234 

Contamination filter for mass spectrometer


Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss..
Dh Technologies Development Pte. Ltd.


04/21/16
20160111521 

Threshold adjustment for quantum dot array devices with metal source and drain


Incorporation of metallic quantum dots (e.g., silver bromide (agbr) films) into the source and drain regions of a mosfet can assist in controlling the transistor performance by tuning the threshold voltage. If the silver bromide film is rich in bromine atoms, anion quantum dots are deposited, and the agbr energy gap is altered so as to increase vt.

04/21/16
20160111271 

Time-of-flight mass spectrometer with spatial focusing of a broad mass range


The invention relates to time-of-flight mass spectrometers which operate with pulsed ionization of superficially adsorbed analyte substances and with an improvement in the mass resolution by means of a time-delayed start of the ion acceleration; in particular with ion-accelerating voltages which change over time after a delayed start in order to obtain a constant mass resolution over broad mass ranges. Since the varying acceleration produces a broadening of the ion beam at right angles to the direction of flight, and this broadening increases with the ion mass, the invention proposes to compensate, to the desired extent, for the broadening of the ion beam with the aid of an additional ion-optical lens whose voltage is also varied over time.

04/21/16
20160111270 

Glow discharge mass spectrometry


A glow discharge mass spectrometry device and method, the device including a glow discharge lamp (1), gas flow-injection elements, the glow discharge lamp being suitable for forming an ablation plasma in the presence of a plasma gas, and a mass spectrometer. The device further includes heating elements (30, 31) suitable for heating a gas flow (38) upstream of a cell (2), the gas flow-injection elements being suitable for injecting into the glow discharge cell a gas flow (38) heated to a temperature t for a duration d, and pumping elements (7, 27) being designed to pump a flow of gaseous species (17, 37) out of the cell for the duration d, so as to decontaminate the surface of the sample (4) and/or the inner walls of the glow discharge cell (2) before an ablation plasma (5) is ignited..

04/21/16
20160111269 

Mass spectrometer, use thereof, and the mass spectrometric examination of a gas mixture


The disclosure relates to a mass spectrometer for mass spectrometric examination of gas mixtures, including: an ionization device and an ion trap for storage and mass spectrometric examination of the gas mixture. In one aspect of the disclosure, the ionization device is embodied for supplying ions and/or metastable particles of an ionization gas and/or for supplying electrons to the ion trap for ionizing the gas mixture to be examined and the mass spectrometer is embodied to determine the number of ions and/or metastable particles of the ionization gas present in the ion trap and/or the number of ions of a residual gas present in the ion trap prior to examining the gas mixture.

04/21/16
20160111266 

Compact mass spectrometer


A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber.

04/21/16
20160109336 

Method and system for determining the concentration of an analyte in a fluid sample


A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected.

04/21/16
20160109333 

Pressure-drop device


Pressure-drop device, useful for gas chromatographs or mass spectrometers, containing a planar base plate, a cover plate, a gas inlet opening, and a gas outlet opening, which are connected by a capillary groove, wherein the capillary groove is embodied as an etched groove or pressed groove in the base plate and covered by the cover plate and wherein a plurality of pressure-drop devices can be connected to form a module.. .

04/14/16
20160104611 

Space focus time of flight mass spectrometer


A time of flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the time of flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times at of ions arriving at the ion detector..

04/14/16
20160103106 

Reference sample for analysis


A reference sample for analysis that is optimal for calibration of a pyrolysis gas chromatograph-mass spectrometer and with which precise calibration is always possible by preventing a reference substance from evaporating is provided. A reference sample sheet 1 is provided by distributing a target component or target components with a uniform normality in a base made of a high polymer material, and the reference sample sheet 1 is rolled up so that the target component or target components can be prevented from evaporating from the reference sample sheet 1 even in the case where a component has volatility.

04/14/16
20160101446 

Method of cleaning turbine blades


In a process for cleaning contaminating silicon dioxide sio2 off of turbine blades, silicon dioxide that is on the turbine blades is reduced selectively in a vacuum process that takes place in dry conditions and at elevated temperature inside a high vacuum furnace, by feeding gas having a reducing action, consisting of hydrogen gas or carbon monoxide, is introduced into the high vacuum furnace. The temperature inside the high vacuum furnace is at least about 1000 degrees celsius, and the residence time of the turbine blades in the high vacuum furnace is determined with reference to the diminishment of the sio concentration, as analysed with a mass spectrometer.

04/07/16
20160099136 

Systems and methods for acquiring data for mass spectrometry images


Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.


04/07/16
20160097748 

Autonomous ambient air sampling system for monitoring semi-volatile/non-volatile organic compounds


An automated ambient air sampling system and method for monitoring organic compounds that may provide continuous data, the system including a thermal desorption system, an injection port, a pre-concentration system, a gas chromatograph and an ion trap mass spectrometer, wherein an air sampling chamber may also function as a thermal desorption chamber.. .
Brigham Young University


03/31/16
20160093482 

Modulation of instrument resolution dependant upon the complexity of a previous scan


Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor.
Dh Technologies Development Pte. Ltd.


03/31/16
20160093480 

Compact mass spectrometer


A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar.
Micromass Uk Limited


03/31/16
20160093479 

Compact mass spectrometer


A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber.
Micromass Uk Limited


03/31/16
20160091386 

Sniffing leak detector having a nanoporous membrane


A sniffing leak detector for sucking in and analyzing gas, including a sniffing probe for sucking in the gas, a gas-conveying pump connected to the sniffing probe, and a mass spectrometer connected to a vacuum pump for analyzing the sucked-in gas in a high vacuum. The gas flow through the sniffing probe is conducted along a membrane having gas-permeable pores.
Inficon Gmbh


03/24/16
20160086785 

Methods and devices for generating double emulsions


The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer.
University Of Washington Through Its Center For Commercialization


03/24/16
20160086784 

Ionization chamber with temperature-controlled gas feed


The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet.
Bruker Daltonik Gmbh


03/24/16
20160086782 

Species detection using mass spectrometry


Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (mrm) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079052 

Method and mass spectrometry


A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (mr tof) mass spectrometry..
Thermo Fisher Scientific (bremen) Gmbh


03/17/16
20160079050 

Mass spectrometry method, ion generator and mass spectrometry system


A mass spectrometry method includes a step of atomizing liquid including a sample using an ultrasonic transducer; a step of transferring the atomized liquid; a step of generating ions from the transferred liquid using a dart ion source; and a step of analyzing a mass spectrometry by introducing the generated ions into a mass spectrometer.. .
Bio Chromato, Inc.


03/17/16
20160079048 

Systems and methods for rapidly screening samples by mass spectrometry


Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079047 

Systems and methods for using variable mass selection window widths in tandem mass spectrometry


Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


03/17/16
20160079046 

Multiple frequency rf amplifier, mass spectrometer including the same, and mass spectrometry mass spectrometer


Provided is a multiple frequency radio frequency (rf) amplifier. The multiple frequency rf amplifier includes a waveform generation circuit configured to generate an rf signal by amplitude and frequency-modulating a reference waveform signal, a drive amplifier circuit configured to drive-amplify the rf signal, and a power amplifier circuit configured to generate a multiple frequency rf voltage signal through a power amplification of the drive-amplified rf signal and output the multiple frequency rf voltage signal to an ion trap for a mass spectrometry..
Korea Basic Science Institute


03/10/16
20160071717 

Orthogonal acceleration system for time-of-flight mass spectrometer


An orthogonal pulse accelerator for a time-of-flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension.
Perkinelmer Health Sciences, Inc.


03/10/16
20160071716 

Maldi imaging and ion source


An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length≦300 mm.
Micromass Uk Limited


03/10/16
20160071713 

Ion implantation system and process for ultrasensitive determination of target isotopes


A system and process are disclosed for ultrasensitive determination of target isotopes of analytical interest in a sample. Target isotopes may be implanted in an implant area on a high-purity substrate to pre-concentrate the target isotopes free of contaminants.
Battelle Memorial Institute


03/10/16
20160071712 

Direct sample analysis device adapters and methods of using them


Certain embodiments described herein are directed to adapters for use in coupling a direct sample analysis device to an analytical instrument such as, for example, a mass spectrometer. In some examples, the adapter can include an internal coupler separated from an external coupler through an insulator..

03/10/16
20160071711 

Imaging mass spectrometric data processing method and imaging mass spectrometer


Compressed data of mass spectra obtained at respective measurement points and normalization coefficients for xic normalization or the like are stored in a memory (21). When a normalized imaging graphic at a specific m/z value is to be displayed, a data decompression processor (23) reads the minimally required set of compressed data from the memory (21) and restores the intensity value corresponding to the m/z value at each measurement point.
Shimadzu Corporation


03/10/16
20160069848 

Liquid chromatograph mass spectrometer


In a liquid chromatograph mass spectrometer (lc/ms) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional lc or similar lc with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the lc depending on the kind of column or other factors or the degree of ease of ionization in the ms. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information.
Shimadzu Corporation


03/03/16
20160064202 

Maldi-tof mass spectrometers with delay time variations and related methods


Maldi-tof ms systems have solid state lasers and successive and varied delay times between ionization and acceleration (e.g. Extraction) to change focus masses during a single sample signal acquisition without requiring tuning of the ms by a user.
Biomérieux, Inc.


02/25/16
20160056030 

System and delicate membrane condensed phase membrane introduction mass spectrometry (cp-mims)


Systems and methods for analyzing a sample comprising an analyte selected from a volatile organic compound, a semi-volatile organic compound, a non-volatile organic compound, a polar organic compound and a halogenated non-volatile organic compound are provided. The systems comprises an ionization source, a flow cell or an immersion probe with a delicate membrane, the flow cell or immersion probe for accepting the sample, and the delicate membrane interface in fluid communication with the ionization source and a mass spectrometer.

02/25/16
20160056029 

Apparatus and methods for an atmospheric sampling inlet for a portable mass spectrometer


Atmospheric sampling system designed to minimize cross-contamination between successive samples acquired by a portable, or handheld, mass spectrometer. Techniques to reduce the overall sample load on portable mass spectrometers having limited pumping capacity, such as capture pumps.
Bayspec, Inc.


02/25/16
20160054276 

Method for establishing shenqi fuzheng injection fingerprint spectrum


A method for establishing a shenqi fuzheng injection fingerprint spectrum, comprising: employing an ultra-high voltage liquid chromatography mass spectrometer to test the shenqi fuzheng injection, the chromatography conditions including: chromatographic column: agilent zorbax eclipse plus c18, 2.1 mm×100 mm, 1.8 μm; mobile phase: mobile phase a is 0.1% formic acid aqueous solution, and mobile phase b is 0.1% formic acid acetonitrile solution; employing gradient elution procedure as follows: 0-0.5 min, 95% of mobile phase a, and 5% of mobile phase b; 0.5-10 min, 95%-75% of mobile phase a, and 5%-25% of mobile phase b; 10-15 min, 75%-45% of mobile phase a, and 25%-55% of mobile phase b; 15-18 min, 45%-0% of mobile phase a, and 55%-100% of mobile phase b; and 18-20 min, 0% of mobile phase a, and 100% of mobile phase b.. .
Li Min Pharmaceutical Factory Of Livzon Pharmaceut Ical Group


02/25/16
20160054224 

Mass spectrometer detector using optically active membrane


A detector suitable for mass spectroscopy uses a thin membrane that converts the kinetic energy of impinging molecules into corresponding photons, the latter detected with a suitable photosensor. The arrival of molecules at the membrane is detected by detection of the corresponding photons..
Wisconsin Alumni Research Foundation


02/18/16
20160049286 

Abridged ion trap - time of flight mass spectrometer


An improved trap-tof mass spectrometer has a set of electrodes arranged to produce both a quadrupolar rf confining field and a substantially homogeneous dipole field. In operation, ions are first confined by the rf field and then, at a selected time, the rf confining field is discontinued and the dipole field is used to accelerate the ions so as to initiate a tof ms analysis.
Bruker Daltonics, Inc.


02/18/16
20160047782 

Mass spectrometry (ms) identification algorithm


A system includes a gas chromatograph configured to determine experimental chromatographic data including retention times associated with samples. The system also includes a mass spectrometer configured to determine experimental mass spectral data associated with samples.
Smiths Detection Inc.


02/11/16
20160042937 

Methods for predictive automatic gain control for hybrid mass spectrometers


A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer.. .
Thermo Finnigan Llc


02/11/16
20160042936 

Compact mass spectrometer


Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.


02/11/16
20160042934 

Lateral introduction of ions into rf ion guides


An ion guide system includes an ion guide with pole rods, a device for laterally introducing an ion species, and a mass spectrometer for analyzing product ions of reactions between different ion species. The device is configured and positioned such that an rf field with at least two-fold rotational symmetry with respect to the axis is generated.
Bruker Daltonik Gmbh


02/11/16
20160042933 

Removal of ions from survey scans using variable window band-pass filtering to improve intrascan dynamic range


Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer.
Dh Technologies Development Pte. Ltd.


02/11/16
20160042930 

Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


02/11/16
20160042929 

Mass spectrometer


A mass spectrometer including a memory unit storing information indicating combinations of precursor ions for cids in respective stages. If an ms1 spectrum on which cid is not performed is obtained during execution of an analysis, a precursor ion selector determines whether an ion registered as a precursor ion for the first-stage cid exists on the ms1 spectrum, based on the list held in the memory unit.
Shimadzu Corporation


02/04/16
20160035558 

Multi-reflecting mass spectrometer


To improve spatial and energy acceptance of multi-reflecting time-of-flight, open traps, and electrostatic trap analyzers, a novel ion mirror is disclosed. Incorporation of immersion lens between ion mirrors allows reaching the fifth order time per energy focusing simultaneously with the third order time per spatial focusing including energy-spatial cross terms.
Leco Corporation


02/04/16
20160035557 

Multi inlet for solvent assisted inlet ionisation


A mass spectrometer is disclosed comprising a dual channel solvent assisted inlet ionisation (“saii”) interface.. .
Micromass Uk Limited


02/04/16
20160035554 

Aperture gas flow restriction


A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture.
Micromass Uk Limited


02/04/16
20160035552 

Method and system for tandem mass spectrometry


A method of data independent ms-ms analysis is disclosed. The method comprises ramping or stepping in small steps of a wide (at least 10 amu) parent mass window in a first parent selecting mass spectrometer (ms1), arranging rapid ion transfer through a collisional cell, either by axial gas flow or by an axial dc field or by a travelling rf wave, frequently pulsing an orthogonal accelerator with a string of time-encoded pulses, analyzing fragment ions in a multi-reflecting time-flight mass spectrometer, acquiring data in a data logging format, and decoding signal strings corresponding to the entire scan of parent masses, such that fragment spectra are formed based on time correlation between fragment and parent masses.
Leco Corporation


02/04/16
20160035550 

Plasma cleaning for mass spectrometers


A mass spectrometry (ms) system may be cleaned by generating plasma and contacting an internal surface of the system to be cleaned with the plasma. The system may be switched between operating in an analytical mode and in a cleaning mode.
Agilent Technologies, Inc.


02/04/16
20160035549 

Hybrid mass spectrometer and methods of operating a mass spectrometer


A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list.
Thermo Finnigan Llc


02/04/16
20160033456 

Gaseous mercury detection systems, calibration systems, and related methods


Embodiments disclosed herein are directed to gaseous mercury detection systems, calibration systems, and related methods. The gaseous mercury detection systems are configured to detect gas-phase mercury-compounds present in ambient air.
Utah State University


01/28/16
20160029472 

Plasma generator using dielectric resonator


A dielectric resonator is excited at its natural resonant frequency to produce highly uniform electric field for the generation of plasma. The plasma may be used optical or mass spectrometer..
Radom Corporation


01/28/16
20160027633 

Collision cell multipole


mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion.
Thermo Fisher Scientific (bremen) Gmbh


01/28/16
20160027629 

Apparatus for elemental analysis of particles by mass spectrometry


A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
Fluidigm Canada Inc.


01/28/16
20160025656 

Microwave plasma spectrometer using dielectric resonator


A dielectric resonator is excited at its natural resonant frequency to produce a highly uniform electric field for the generation of plasma. The plasma may be used as a desolvator, atomizer excitation source and ionization source in an optical spectrometer or a mass spectrometer..
Radom Corporation


01/21/16
20160020082 

Mass spectrometer system and method


An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage u, an amplitude v of a radio-frequency voltage, and a frequency f of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger.
Hitachi High-technologies Corporation


01/21/16
20160020081 

Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer


Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows msn experiments to be performed on very basic mass spectrometers, even those without secondary mass analyzers and/or collision cells.
Wisconsin Alumni Research Foundation


01/21/16
20160020080 

Sample plate for maldi-tof mass spectrometer and manufacturing the sample plate and mass spectrometry method using the sample plate


The present invention relates to a sample plate to be used for a maldi-tof (matrix assisted laser desorption ionization time of flight) mass spectrometer, and more particularly, to a sample plate for a maldi-tof mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a maldi-tof mass spectrometer so as to overcome the limits of the gas chromatography method of the related art.
Industry-academic Cooperation Foundation, Yonsei University


01/21/16
20160018410 

Deep maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof


A method of analyzing a biological sample, for example serum or other blood-based samples, using a maldi-tof mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a maldi-tof sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument.
Biodesix, Inc.


01/21/16
20160018361 

System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry


An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges.

01/14/16
20160013040 

Ion trap mass spectrometer


An ion trap mass spectrometer including an ion trap analyzer, an ion packet injector, and an ion detector is disclosed, along with a method of mass spectrometry. The ion packet injector injects packets of ions into a field of the ion trap analyzer.
Leco Corporation


01/14/16
20160013038 

Use of mass spectral difference networks for determining charge state, adduction, neutral loss and polymerization


A mass spectrometric analysis method comprises: (1) processing a mass spectrum to reduce the signals to monoisotopic values; (2) creating a list of differences between the monoisotopic values; (3) creating one or more lists of theoretical mass-to-charge differences among known adducts, charge states and polymerization states whose formation may be expected from various analyte molecules; (4) comparing the theoretical differences (line or edge in the network) to the list of differences from the mass spectrum and, where applicable, make and tabulate tentative species assignments; (5) assigning the mass spectral peaks to respective ion species in accordance with the redundancy of each assignment based on multiple independent calculated mass-to-charge differences pertaining to each peak; (6) choosing an ion species for further fragmentation or reaction in the mass spectrometer, based on the assigning; and (7) performing the fragmentation or reaction on the chosen ion species in the mass spectrometer.. .
Thermo Finnigan Llc


01/14/16
20160013036 

Improved lock component corrections


A method of mass spectrometry is disclosed comprising initially calibrating or recalibrating a mass spectrometer at a time t0 and at the same time measuring a time of flight or mass to charge ratio m0 of one or more lockmass ions. The mass spectrometer is then operated at a subsequent time t1 and the time of flight or mass to charge ratio m1 of the one or more lockmass ions is measured at subsequent time t1.
Micromass Uk Limited




Mass Spectrometer topics: Mass Spectrometer, Spectrometer, Mass Spectrometry, Spectrometry, Downstream, Coordinates, Quantitative, Chromatograph, Data Processing, Biomolecule, Data Acquisition, Electrical Signal, Data Compression, Fragmentation, Irradiation

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