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Mass Spectrometer patents

      

This page is updated frequently with new Mass Spectrometer-related patent applications.




 Tandem quadrupole mass spectrometer patent thumbnailTandem quadrupole mass spectrometer
A dwell time calculation table (51a) showing a correspondence relation between a cid gas pressure inside a collision cell (31) and a dwell time for data collection is stored in a processing condition parameter memory (51) of a controller (50). In the table (51a), as the cid gas pressure becomes higher, the dwell time becomes longer.
Shimadzu Corporation


 Electrostatic mass spectrometer with encoded frequent pulses patent thumbnailElectrostatic mass spectrometer with encoded frequent pulses
A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
Leco Corporation


 Systems and methods for ion isolation patent thumbnailSystems and methods for ion isolation
A mass spectrometer includes a radio frequency ion trap and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap and supply an isolation waveform to the radio frequency ion trap.
Thermo Finnigan Llc


 Systems and methods for ion isolation using a dual waveform patent thumbnailSystems and methods for ion isolation using a dual waveform
A mass spectrometer includes a radio frequency ion trap; and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap; supply a first isolation waveform to the radio frequency ion trap for a first duration, and supply a second isolation waveform to the radio frequency ion trap for a second duration.
Thermo Finnigan Llc


 Systems and methods for delivering liquid to an ion source patent thumbnailSystems and methods for delivering liquid to an ion source
Methods and systems for delivering a liquid sample to an ion source are provided herein: in various aspects, the methods and systems described herein can utilize the flow provided by an lc pump(s) to drive a calibration fluid to an ion source of a mass spectrometer system. In various aspects, methods and systems described herein can additionally or alternatively be placed upstream of an lc column for providing an elution gradient of a plurality of solvents, without requiring a plurality of pumps and/or separate mixing elements..
Dh Technologies Development Pte. Ltd.


 Auxiliary gas inlet patent thumbnailAuxiliary gas inlet
There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a matrix assisted laser desorption ionisation (“maldi”) ion source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.. .
Micromass Uk Limited


 Auxiliary gas inlet patent thumbnailAuxiliary gas inlet
There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a continuous ionisation source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.. .
Micromass Uk Limited


 Pressure driven microfluidic injection for chemical separations patent thumbnailPressure driven microfluidic injection for chemical separations
Methods that allow independently applied pressures to a bge reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer..
The University Of North Carolina At Chapel Hill


 Mass spectrometer and mass spectrometry method patent thumbnailMass spectrometer and mass spectrometry method
A mass spectrometer including an ionization source including an esi probe (201), an esi power source (24), a corona needle (202) and an apci power source (24); an ionization condition storage section (41) for storing a plurality of ionization conditions related to the liquid sample, set by an analysis operator, with the ionization conditions differing from each other in the value of the esi voltage or/and the value of the apci voltage; a mass spectrometry executer (43) for conducting a mass spectrometry for an ion generated from the liquid sample using each of the plurality of ionization conditions; and a mass spectrometry result selector (44) for selecting, for each of the one or plurality of components, a mass spectrometry result in which the ion is detected with a suitable level of intensity for an analysis, from the mass spectrometry results respectively obtained for the plurality of ionization conditions.. .
Shimadzu Corporation


 Homogenization of the pulsed electric field created in a ring stack ion accelerator patent thumbnailHomogenization of the pulsed electric field created in a ring stack ion accelerator
A ring stacked accelerator for use in a mass spectrometer includes a plurality of ring shaped plates arranged in a stack and is electrically coupled to a voltage divider that allows a substantially homogeneous electric field to be produced when the stack is energized. The voltage divider can include resistors and capacitors, where the capacitors are chosen to compensate for parasitic capacitances experienced by the plates.
Dh Technologies Development Pte. Ltd.


Mass spectrometer

The objective of the present invention is to obtain an ms2 spectrum for each of a plurality of different ion species even when their m/z values are extremely close to each other and prevent separate setting of each ion species as the precursor ion. In the vicinity of the target m/z, a precursor-ion selection window covering a predetermined m/z range (2×Δm) is gradually shifted in predetermined steps (Δm) to define a plurality of windows as the condition of the precursor-ion selection.
Shimadzu Corporation

Ion mobility analyzer and mass spectrometer

A drift voltage generator applies voltages to a plurality of annular electrodes, respectively, so that a potential distribution φ on an ion beam axis of an accelerating electric field created within a drift region satisfies ∂2φ/∂z2>0. Trailing ions undergo a higher rate of acceleration than preceding ions, so that a compressing force acts on an ion packet in the direction of the ion beam axis.
Shimadzu Corporation

Globally optimized targeted mass spectrometry (got-ms)

Globally optimized targeted (got)-ms, combines many of the advantages of targeted detection and global profiling in metabolomics analysis, including the capability to detect unknowns, broad metabolite coverage, and excellent quantitation. A global search of precursor and product ions using a single triple quadrupole (qqq) mass spectrometer includes sim incremental scanning or incremental ms scanning performed in the mass range of 40-2000 da, followed by tandem ms/ms scanning with incremental collision energy for precursor ions to profile product ions..
University Of Washington

System for transferring ions in a mass spectrometer

A system for transporting ions includes: an ion transfer tube having an axis and an internal bore having a width and a height less than the width; and an apparatus comprising a plurality of electrodes, each having a respective ion aperture having an aperture center, the apertures defining an ion channel configured to receive the ions from the ion transfer tube and to transport the ions to an outlet end of the apparatus, wherein at least a subset of the apertures progressively decrease in size in a direction towards the apparatus outlet end, wherein the ion transfer tube is configured such that the ion transfer tube axis is non-coincident with an axis of the ion channel or such that the width dimension of the ion transfer tube bore is parallel to a plane defined by the ion transfer tube axis and the ion channel axis.. .
Thermo Finnigan Llc

Isotopic enrichment of helium-3 through glass

Disclosed is a mass selective fluid bandpass filter. This filter provides for selecting gas molecules of a specific mass from a gas sample containing molecules of two or more mass species.

Methods and systems for high speed laser surgery

The present disclosure relates to a methods and systems for high speed laser surgery. In some implementations, the combination of mid-infrared (mid-ir) laser radiation with micro-scanning technology allows for large tissue ablation rates with minimal thermally affected zones, where micro-scanning distributes the heat generated by laser surgery over a large tissue area.
Imra America, Inc.

High speed polarity switch time-of-flight spectrometer

In one aspect, a mass spectrometer is disclosed that includes a time-of-flight analyzer (tof), which comprises an accelerator stage comprising a plurality of electrodes and adapted to receive and accelerate a plurality of ions, and a drift chamber disposed downstream of said accelerator stage for receiving at least a portion of the accelerated ions. The tof analyzer further comprises a pulser coupled to the accelerator stage for applying one or more voltages to said plurality of electrodes, and a controller coupled to the pulser and adapted to cause the pulser to adjust said one or more voltages applied to the electrodes so as to configure the accelerator stage to receive and accelerate positive and negative ions during different cycles of an ion detection period..
Dh Technologies Development Pte. Ltd.

Tandem mass spectrometer and tandem mass spectrometry method

The invention relates to a tandem mass spectrometer comprising an ionization source that can produce ions; a mass analyser comprising an ion trap arranged in such a way as to receive ions from the ion source and a detector that can detect ions leaving the ion trap according to the mass to charge (m/z) ratio thereof; ion activation means for activating ions that can fragment at least some of the ions trapped in the ion trap; and coupling means arranged between the ion trap and said ion activation means. According to the invention, the ion activation means consists of a glow discharge lamp that can generate a light beam oriented towards the ion trap, said light beam being electromagnetic radiation in the vacuum ultraviolet wavelength range with photon energies of between 8 ev and 41 ev in such a way as to fragment at least some of the ions trapped in the ion trap..
Synchrotron Soleil

Method of producing a mass spectrum

A method of producing a mass spectrum from a time-varying transient signal detected in a mass spectrometer, the method comprising: performing a fourier transform of the transient signal to produce a first set of complex amplitudes wherein each of the complex amplitudes corresponds to a respective frequency of a first set of frequencies; generating a second set of complex amplitudes, wherein each of the complex amplitudes corresponds to a respective frequency of a second set of frequencies with a minimum spacing less than the inverse of the duration of the transient signal; optimizing the second set of complex amplitudes to produce an improved second set; generating a mass spectrum from at least some of the improved second set of complex amplitudes; wherein optimizing the second set of complex amplitudes to produce an improved second set of complex amplitudes is based on an objective function subject to some phase constraints.. .
Thermo Fisher Scientific (bremen) Gmbh

Mass spectrometer and mass spectrometry method

The degree of ion dissociation which occurs within a first intermediate vacuum chamber (212) maintained at a comparatively low degree of vacuum depends not only on the amount of energy of the ion but also on the size and other properties of the ion. Accordingly, a predetermined optimum level of dc bias voltage is applied to an ion guide (24) so as to create, within the first intermediate vacuum chamber (212), a dc electric field which barely induces the dissociation of an ion originating from a target compound in a sample while promoting the dissociation of an ion originating from a foreign substance which will form a noise signal in the observation of the target compound.
Shimadzu Corporation

Atmospheric interface for electrically grounded electrospray

An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube.
Waters Technologies Corporation

Hybrid ion source, mass spectrometer, and ion mobility device

Provided is an ion source achieving high sensitivity and high robustness while executing a plurality of types of ionization schemes. To this end, a hybrid ion source (1) includes: a chamber (24); a first ion source (2) to spray a sample solution (5) for ionization; a second ion source (3) to ionize droplets and/or a gas component sprayed from the first ion source (2); a first electrode (11) to introduce a first ion (7) generated by the first ion source (2), and a second ion generated by the second ion source (3); and an exhaust pump (27) that generates air flow (26) in a direction from a first space area (23) where the first ion (7) is generated to a second space area (19) in the second ion source (3) where the second ion is generated..
Hitachi High-technologies Corporation

Automated beam check

A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching on the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions.
Micromass Uk Limited

Tool free gas cone retaining device for mass spectrometer ion block assembly

A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising an ion block or sub-assembly having an internal passage. The atmospheric pressure interface further comprises either an inner sampling cone, a capillary interface or other gas limiting interface.
Micromass Uk Limited

High frequency voltage supply control multipole or monopole analysers

A voltage supply system for supplying an rf voltage to an rf resonant load comprising an ion-optical component of a mass spectrometer is disclosed. The system comprises a direct digital synthesiser (“dds”) arranged and adapted to output an rf voltage.
Micromass Uk Limited

Mass spectrometry clinical diagnostic applications

A mass spectrometer system for analysis of clinical samples includes a source of clinical samples. A controller receives the clinical samples from the source of clinical samples.
Virgin Instruments Corporation

Method for fabricating light-emitting element and light-emitting element

A light-emitting element and its fabrication method are provided. The light-emitting element includes an el layer between a pair of electrode, and the el layer is formed by evaporation of an organic compound.
Semiconductor Energy Laboratory Co., Ltd.

Energy resolved time-of-flight mass spectrometry

A time-of-flight mass spectrometer (tof-ms) utilizes an ion dispersion device and a position-sensitive ion detector or an energy-sensitive ion detector to enable measurement of time of flight and kinetic energy of ions arriving at the detector. The measurements may be utilized to improve accuracy in calculating ion masses..
Agilent Technologies, Inc.

Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry

A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.. .
Wayne State University

Ruggedized advanced identification mass spectrometer

A dual-ionization mass spectrometer includes a first mass spectrometer module forming a hard ionization mass spectrometer, a second mass spectrometer forming a soft ionization mass spectrometer, a vacuum ultraviolet light source positioned between the first and second modules, a housing encompassing the first and second sets of plates and the light source, and an inlet positioned to receive a sample of an analyte and provide it to at least one of the sets of plates. A method of detecting a substance includes receiving a sample of an analyte into a housing through an inlet, performing soft ionization mass spectrometry on the sample with a soft ionization mass spectrometer in the housing, performing hard ionization spectrometry on the sample with a hard ionization spectrometer in the housing if needed, and generating a detection result from at least one of the soft ionization spectrometry and the hard ionization spectrometry..
Sri International

Concentric apci surface ionization ion source, ion guide, and use

A concentric apci surface ionization probe, supersonic sampling tube, and method for use of the concentric apci surface ionization probe and supersonic sampling tube are described. In an embodiment, the concentric apci surface ionization probe includes an outer tube, an inner capillary, and a voltage source coupled to the outer tube and the inner capillary.
Smiths Detection Montreal Inc.

Ion source system for atmospheric pressure interface, and mass spectrometer

Provided is an ion source system for an atmospheric pressure interface, comprising an atmospheric pressure ion source (1), wherein the atmospheric pressure ion source (1) is connected downstream to a vacuum ion source (2). Also provided is a mass spectrometer, using the present ion source system as an ion source.
Beijing Institute Of Technology

Ion trap mass spectrometers

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region; selecting a target maximum charge desired to be stored within the ion storage region at any given time; and reducing the ion current passing to the ion storage region such that the ions entering the ion storage region do not cause the total charge within the storage region to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region comprises: temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter.
Micromass Uk Limited

Focusing ionization device and mass spectrometer using the same

A focusing ionization device includes a ball having a surface with a plurality of dimples and a metal needle located at one side of the ball and capable of generating corona discharge. The focusing ionization device is adapted for being disposed in a mass spectrometer in a way that the ball is located at a spray path of gaseous analytes and the metal needle is located adjacent to a sample inlet of a mass analyzer.
National Chung Hsing University

Ion focusing member and mass spectrometer using the same

An ion focusing member includes a ball having a surface with a plurality of dimples. The ion focusing member is adapted for being disposed in a mass spectrometer in a way that the ball is located at a spray path of analyte ions and located between a metal capillary and a mass analyzer.
National Chung Hsing University

Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers

Mass spectrometry cells include one or more interleaved magnetostatic and electrostatic lenses. In some examples, the electrostatic lenses are based on electrical potentials applied to magnetostatic lens pole pieces.
Oregon State University

Sample inlet and vacuum system for portable mass spectrometer

An inlet and vacuum system for a portable, or handheld, mass spectrometer. The mass spectrometer comprises three vacuum chambers, which includes two ion funnels connected in series in the first two vacuum chambers, followed by a mass spectrometer analyzer and ion detector in the third vacuum chamber.
Bayspec, Inc.

Mass spectrometer and liquid-metal ion source for a mass spectrometer of this type

The invention relates to a mass spectrometer comprising an ion source for producing a primary ion beam, which has a heatable ion emitter coated by a liquid metal layer essentially comprised of pure metallic bismuth or of a low-melting-point alloy containing, in essence, bismuth. A bismuth ion mixed beam can be emitted by the ion emitter under the influence of an electric field.
Ion-tof Technologies Gmbh

System and high throughput mass spectrometric analysis of proteome samples

Disclosed herein is a system and method for analyzing a specimen containing the proteome by mass spectrometry. The system includes a protein separation module; a matrix processing module; and a mass spectrometer module.
Northwestern University

Multiplexing of ions for improved sensitivity

Systems and methods are provided for multiplexed precursor ion selection using a filtered noise field (fnf). Two or more different precursor ions are selected using a processor.
Dh Technologies Development Pte. Ltd.

Mass spectrometer

A mass spectrometer includes: an ionization unit configured to ionize an analyte gas; a filter unit configured to allow passage of only a target ion which is a component of the analyte gas ionized in the ionization unit and which has a specific mass-to-charge ratio; and an ion detection unit configured to detect an ion detection value based on the target ion having passed through the filter unit, wherein the ion detection unit includes a faraday electrode which includes an electrode portion disposed along a centerline of the filter unit and a bottom electrode provided at a position downstream of the electrode portion in a flow of the target ion, the electrode portion and the bottom electrode being connected to each other, a secondary electron multiplier provided to face the electrode portion with the centerline located therebetween, and a blocking portion connected to the bottom electrode.. .
Canon Anelva Corporation

Open trap mass spectrometer

An open electrostatic trap mass spectrometer is disclosed for operation with wide and diverging ion packets. Signal on detector is composed of signals corresponding to multiplicity of ion cycles, called multiplets.
Leco Corporation

Flow through ms3 for improved selectivity

Systems and methods are provided for selecting and fragmenting a first precursor ion in an ms3 experiment. One or more first excitation parameters are calculated that define a first dipole excitation using a processor.
Dh Technologies Development Pte. Ltd.

Chromatograph mass spectrometer

A chromatograph mass spectrometer including an optimum gas pressure search controller that performs an mrm measurement for a target compound while changing a collision-gas pressure, investigates an optimum collision-gas pressure giving a highest signal strength based on the measured result, and stores the same gas pressure for each compound in a compound-related information storage section. When a target compound is specified in a simultaneous multicomponent analysis, a control sequence determiner reads the optimum collision-gas pressure and retention time information corresponding to the specified compound from the storage section, prepares a control sequence which sets the gas pressure in a collision cell at the optimum gas pressure at the timing where each compound is eluted, and stores the sequence in a control sequence storage section..
Shimadzu Corporation

Method and mass analysis utilizing ion charge feedback

A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyser; the batch of ions accumulated in the mass analyser is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyser is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyser; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyser.. .
Thermo Fisher Scientific (bremen) Gmbh

Multireflection time-of-flight mass spectrometer

A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location.
Thermo Fisher Scientific (bremen) Gmbh

Mass spectrometers comprising accelerator devices

A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
Micromass Uk Limited

Interface for ion source and vacuum housing

A mass spectrometer or ion mobility spectrometer is disclosed comprising: an ion block (2) for receiving ions; a heater (8) for heating the ion block (2); a vacuum housing (6); and an interface block (4) arranged between the ion block (2) and the vacuum housing (6); wherein the interface block (4) is formed from a polymer. The polymer interface block (4) inhibits the heat transfer from the ion block (2) to the vacuum housing (6) and also electrically isolates the ion block (2) and vacuum housing (6).
Micromass Uk Limited

Automated cleanliness diagnostic for mass spectrometer

A mass spectrometer or ion mobility spectrometer is disclosed comprising means for detecting a blockage in an inlet orifice arranged between an ion source and a vacuum chamber. The blockage is detected as a result of a reduction in pressure within the vacuum chamber.
Micromass Uk Limited

Gasket seal for a mass spectrometer

A gasket seal for a mass spectrometer is disclosed. The gasket seal comprises a membrane having an outer profile and an inner profile and one or more protrusions.
Micromass Uk Limited

Ion inlet assembly

An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body having a sampling orifice. The sampling limiting body comprises a nickel disk wherein the disk and sampling orifice are made or formed by an electroforming process..
Micromass Uk Limited

Gas diffuser ion inlet

In some embodiments, a gas diffuser for use in a mass spectrometer is disclosed that can provide a controlled expansion of an ion-containing gas so as to reduce gas velocity for entry into subsequent stages of the mass spectrometer, e.g., a mass analyzer. In some embodiments, the controlled expansion of the gas is provided by flowing the gas through a channel whose cross-sectional area change, e.g.
Dh Technologies Development Pte.ltd.

Mass spectrometer

Apparatus for a mass spectrometer is disclosed comprising an ion source, a heater for heating a gas flow to the ion source, a temperature sensor for monitoring the temperature of the heater, and a control system. The control system is arranged and adapted to determine a flow rate of the gas flow by monitoring the power supplied to the heater and the temperature of the heater..
Micromass Uk Limited

Ion transfer

An ion transport device can include a plurality of pole rod pairs arranged in parallel, and a controller. The controller configured to can be configured to apply voltages in a repeating voltage pattern of to the pole rod pairs thereby creating a plurality of potential wells capable of capturing ions, and move the repeating voltage pattern along the pole rod pairs to move captured ions along the ion transport device.
Thermo Finnigan Llc

Systems and methods for using interleaving window widths in tandem mass spectrometry

Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.

Parsing events during ms3 experiments

Systems and methods are provided for reducing the time period of a cid event of an ms3 experiment and making the overall fragmentation event more generic. A cid event of an ms3 experiment performed on a sample by a mass spectrometer is divided into two time periods using a processor.
Dh Technologies Development Pte. Ltd.

Multidrug analysis in urine by liquid chromatography-tandem mass spectrometry

A fast and reliable method for the determination of multiple drugs and their metabolites belonging to different chemical and toxicological class from a biological sample is provided. The method involves mixing of biological sample with internal standards which does not require sample extraction or derivatization prior to analysis.
Castle Medical, Llc

Use of windowed mass spectrometry data for retention time determination or confirmation

A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans.
Dh Technologies Development Pte. Ltd.

Chamber seal for mass spectrometer

A mass spectrometer is disclosed comprising a first component, an annular vacuum chamber seal and a second component. The first component has a groove.
Micromass Uk Limited

Time-of-flight mass spectrometry using multi-channel detectors

A time-of-flight mass spectrometer (tof-ms) utilizes a multi-channel ion detector to detect ions traveling in separate flight paths, spatially dispersed along a drift axis and/or a transverse axis, in a flight tube of a tof analyzer. The ion beams may be dispersed by drift energy, deflection along the drift and/or transverse axis, ion mass, or a combination of two or more of the foregoing.
Agilent Technologies,inc.

Miniature ion source of fixed geometry

A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μl/min.
Micromass Uk Limited

Pulsed ion guides for mass spectrometers and related methods

An ion guide generates a radio frequency (rf) field to radially confine ions to an ion beam along a guide axis as the ions are transmitted through the ion guide. The effective potential of the rf field includes an alternating series of barriers and wells.
Agilent Technologies, Inc.

Method and transporting samples in a mass spectrometer

A sample plate handling system for a time-of-flight mass spectrometer includes a transport chamber and a mass spectrometer chamber that is mechanically coupled to transport chamber. A vacuum chamber is coupled through a bypass valve to the transport chamber.
Virgin Instruments Corporation

Data independent acquisition of product ion spectra and reference spectra library matching

Systems and methods are disclosed for detecting compounds in a sample using a tandem mass spectrometer. A sample comprising a plurality of detectable compounds that have been separated in time over a time interval is introduced into a tandem mass spectrometer.
Eth Zürich

Rf-only detection scheme and simultaneous detection of multiple ions

A mass spectrometer apparatus and method for conducting simultaneous ms/ms analysis including: a device to select a precursor ion having a specified m/z; a gas-filled collision cell; an rf-only multipole mass spectrometer, the mass spectrometer having a generator attached thereto for generating at least two auxiliary ac fields in the rf-only multipole mass spectrometer; a gate for providing a repulsive dc or ac barrier downstream to an exit of the rf-only multipole mass spectrometer; an ion detection system situated downstream from the dc or ac barrier for measuring an ion current derived from ions that overcome the repulsive barrier. The mass spectrometer may also be configured so that each of the auxiliary ac fields are generated by the introduction of individual auxiliary ac frequencies and each frequency is amplitude modulated at a unique frequency..
Dh Technologies Development Pte. Ltd.

Fragment ion mass spectra measured with tandem time-of-flight mass spectrometers

The present invention provides a method for acquiring fragment ion mass spectra with a time-of-flight mass spectrometer, whereby mixed mass spectra with fragment ions of different parent ion species are acquired and compared with each other in such a way that the signals of those fragment ions which originate from the same parent ion species are determined. The time-of-flight mass spectrometer contains an ion source, a flight path, a reflector and an ion detector.
Bruker Daltonik Gmbh

Gas chromatograph-mass spectrometer

A column protection gas supply channel (4) is connected to a channel (17) for carrier gas present between a sample vaporization chamber (12) and an ms section (2). During a standby, a column (11) may be protected on the downstream side of a merging section (16) of the column protection gas supply channel (4) and the channel (17) for carrier gas by supplying column protection gas through the column protection gas supply channel (4).
Shimadzu Corporation

Sniffer leak detector with multi-stage membrane pump

A sniffer leak detector includes a mass spectrometer for analyzing hydrogen or helium, a turbomolecular pump which is connected with said mass spectrometer and whose outlet is connected with a prevacuum pump, and a sniffer probe which includes a plurality of intake lines and is connected with said inlet of said turbomolecular pump, wherein a vacuum pump includes at least three stages whose inlet stage defines said prevacuum pump and is connected with said outlet of said turbomolecular pump via a blocked throttle, wherein, between adjacent stages of said vacuum pump, an intermediate inlet each is provided, wherein each intermediate inlet is connected with a different intake line of said sniffer probe and at least one of the intake lines as a suction line is connected with said inlet of said turbomolecular pump for obtaining different gas flows.. .
Inficon Gmbh

Time-of-flight mass spectrometer

An embodiment of the invention relates to a tof-ms capable of performing mass spectrometry of a sample at a high throughput. The tof-ms has an acceleration part for accelerating an ion, a detector for detecting an event of arrival of the accelerated ion, and a data processing part for performing mass spectrometry of the sample, based on a time of flight of the ion.
Hamamatsu Photonics K.k.

Probe assembly for attaching a chromatography device to a mass spectrometer

A probe assembly is disclosed comprising an inlet for receiving an eluent from a chromatography device; an outlet (120) for delivering the eluent to an ion source of a mass spectrometer; and an attachment device (122) for attaching the outlet to the mass spectrometer. The outlet comprises an electrically conductive capillary (124) and an electrically conductive member (129) surrounding at least part of the electrically conductive capillary (124).
Micromass Uk Limited

System for recording spatial and temporal properties of ions emitted from a quadrupole mass filter

An ion detection system for a detecting a quantity of ions exiting from a mass analyzer of a mass spectrometer comprises: (a) photon generating means configured to receive the quantity of ions and to generate a quantity of photons that is proportional to the quantity of ions; (b) a linear array of photo-detectors configured along a line for detecting a variation of a portion of the quantity of generated photons along the line; and (c) an optical system for directing the portion of the quantity of photons from the photon generating means to the linear array of photo-detectors comprising: (c1) a first cylindrical lens having a first lens axis disposed parallel to the line; (c2) a second cylindrical lens or rod lens having a second lens axis disposed parallel to the line; and a doublet lens.. .
Thermo Finnigan Llc

Multiplexed precursor isolation for mass spectrometry

Systems and methods for identifying precursor ions of product ions from combined product ion spectra are provided. N precursor ions are selected.
Dh Technologies Development Pte. Ltd.

Peak assessment for mass spectrometers

A method of assessing mass spectral peaks obtained by a mass spectrometer is disclosed. The method comprises: providing experimentally obtained mass spectral data; selecting a chemical compound thought to have been analysed so as to provide said experimentally observed data, and modelling the spectral data predicted to be detected if the compound was to be mass analysed.
Micromass Uk Limited

Targeted mass analysis

A mass spectrometer comprises: an ion source that generates ions having an initial range of mass-to-charge ratios; an auxiliary ion detector, downstream from the ion source that receives a plurality of first ion samples derived from the ions generated by the ion source and determines a respective ion current measurement for each of the plurality of first ion samples; a mass analyser, downstream from the ion source that receives a second ion sample derived from the ions generated by the ion source and to generate mass spectral data by mass analysis of the second ion sample; and an output stage that establishes an abundance measurement associated with at least some of the ions generated by the ion source based on the ion current measurements determined by the auxiliary ion detector.. .
Thermo Fisher Scientific (bremen) Gmbh

Mass spectrometer electrode

A monolithic electrode includes a first portion devoid of apertures and a second portion surrounded by the first portion, the second portion having a web defining a plurality of apertures. A method for forming an electrode includes forming a first electrode portion devoid of apertures and forming a second electrode portion having a web defining a plurality of apertures.
Hamilton Sundstrand Corporation

Method of calibrating mass-to-charge ratio measurements obtained from a mass spectrometer connected in fluid communication with an analysis system delivering a temporally changing sample

A method of calibrating mass-to-charge ratio measurements obtained from a mass spectrometer connected in fluid communication with a chromatographic system comprises the steps of acquiring a multiplicity of mass spectra of an analyte during an analytical run, analyzing at least some of the multiplicity of mass spectra during the analytical run for generating result data relating to a decision on introduction of a calibrant material into the mass spectrometer; and introducing the calibrant material into the mass spectrometer during the analytical run, based on the result data. An arrangement for mass analysis that is suitable for carrying out the method comprises a chromatographic system (10), a mass spectrometer (20) connected downstream, in fluid communication to the chromatographic system (10), a data acquisition device (22) for acquiring mass spectra of an analyte fed to the mass spectrometer (20), a controllable injector (30, 31) to introduce calibrant material into the mass spectrometer, and a control unit (50) receiving information on the acquired mass spectra from the data acquisition device (22), the control unit (50) configured to dynamically control the injector (30, 31) based on the received information..
Tofwerk Ag

Chromatograph mass spectrometer

When setting analysis conditions, an analysis operator sets, on a dwell-time calculation/loop-time listing window, the target value of a loop time corresponding to the measurement-time interval to repeat an analysis for one ion, and clicks a dwell time calculation button. Then, a dwell time calculator computes the dwell time for each event, based on the target value of the loop time, the arrangement of events set at that point in time, the number of target ion species set in each event, and other conditional factors.
Shimadzu Corporation

Gas analyzer with fuel cell

The invention relates to gas analyzers, especially mobile ion mobility spectrometers or mass spectrometers which are operated at atmospheric pressure to detect dangerous substances. The invention uses a fuel cell to generate the electric operating power of the gas analyzer, and the waste heat from the fuel cell is used to regulate the temperature of modules of the gas analyzer..
Bruker Daltonik Gmbh

Remote laser ablation electrospray ionization mass spectrometry

In various embodiments, a device may generally comprise a remote ablation chamber comprising an inlet and an outlet, a laser to deposit energy into a sample in the chamber to ablate the sample and generate ablation products in the chamber, a transport device in fluid communication with the outlet, an ionization source to ionize the ablation products to produce ions, and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation products or the ions may be transported in a fluid stream from the ablation chamber through the transport device.
The George Washington University

Mass spectrometer

The present disclosure provides a mass spectrometer for performing an analysis of sample ions, and a method for operating a mass spectrometer. The mass spectrometer comprises a first ion optical element that is supplied with a first gas; a mass analyzer, wherein the performance of the mass analyzer is dependent on the pressure of the first gas in the first ion optical element; and a controller for setting a property of the first gas, which comprises at least the pressure of the first gas, on the basis of a characteristic of the analysis to be performed by the mass spectrometer..
Thermo Fisher Scientific (bremen) Gmbh

Hybrid ion source and mass spectrometric device

In order to provide an ion source that can be easily switched with high sensitivity and in a short time, the ion source includes an ionization probe for spraying a sample, a heating chamber for heating and vaporizing a sample; and driving portions and for changing the distance between an outlet end (i.e., an end on the spray side) of the ionization probe and an inlet end (i.e., an end on the ionization probe side) of the heating chamber. The positions of the ionization probe and the heating chamber are controlled by the driving portions so that an ionization region that uses the ionization probe or an ionization region that uses the heating chamber is positioned near the ion inlet port of the mass spectrometer..
Hitachi High-technologies Corporation

Methods for determination of total homocysteine

Disclosed herein are simple, rapid and cost effective methods for determination of endogenous sulfhydryl amino acid species from a sample, example a sample in clinical practice. The method can include mixing of a biological sample with an internal standards which does not require pretreatment or derivatization and/or isotopic dilution.
Castle Medical, Llc

Structured biological samples for analysis by mass cytometry

Apparatus and methods for delivering biological samples to an icp source of a mass cytometer are disclosed. Biological material is disposed on a plurality of discrete sites on a carrier.
Fluidigm Canada Inc.

Triple quadrupole mass spectrometer

The present triple quadrupole mass spectrometer determines the relationship between a parameter, such as the mass-to-charge ratio of a precursor ion or that of a product ion, and the optimal collision-gas pressure giving the highest signal intensity in an mrm measurement, derives an approximate equation expressing that relationship, and stores the information representing the equation in an optimum collision-gas pressure calculation information storage section. When a measurement is to be performed, an analysis operator enters the mass-to-charge ratio of a precursor ion or product ion of a target compound.

Ion transport apparatus and mass spectrometer using the same

Within an intermediate vacuum chamber next to an ionization chamber maintained at atmospheric pressure, an electrode group of a radio-frequency carpet composed of a plurality of concentrically arranged ring electrodes is placed before a skimmer, with its central axis coinciding with that of an ion-passing hole. Each ring electrode has a circular radial sectional shape.

Multi-element isotopic measurement by direct coupling of a multi-cycle isotachophoresis technique and a mass spectrometry technique

A method for separating electrically charged species contained in a solution by an isotachophoresis method applied in an electrophoresis device, the isotachophoresis method being coupled to isotopic measurement using a mass spectrometer. The method notably comprises a step of stopping the voltage applied to the terminal of the electrophoresis capillary and transient application of a counter-pressure making it possible to utilize the length of the capillary several times and extend the separation distance artificially..

Mass spectrometer inlet with reduced average flow

An interface configured to transfer ions produced at or near atmospheric pressure conditions into a mass spectrometer for mass analysis is provided. The interface includes a first conduit including an inlet configured to receive a fluid containing the ions and an outlet configured to direct the fluid containing the ions into the mass spectrometer.

Bubble removal from liquid flow into a mass spectrometer source

Methods and systems for delivering a liquid sample to an ion source are provided herein. In various aspects, the methods and systems can improve the stability of a flow of liquid sample delivered to an ion source.

Sample quantitation with a miniature mass spectrometer

The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte.

Tuning a mass spectrometer using optimization

Systems, methods, and apparatuses are provided for tuning a mass spectrometer. An optimization process can be performed to determine optimal parameters for various physical parameters of elements of the mass spectrometer.

Analytical detecting fuel markers

A gas chromatographic method for detecting a first marker and a second marker in a fuel in two channels: (i) a first capillary column coated with polysiloxane and a second capillary column coated with polyethylene glycol; and (ii) a third capillary column coated with polymethylphenylsiloxane and a fourth deactivated capillary column. The steps are: (a) introducing a first sample into the first column to produce a first effluent; (b) introducing only a portion of the first effluent into the second column to produce a second effluent; (c) allowing the second effluent to pass through a mass spectrometer; (d) introducing a second sample into the third column to produce a third effluent; (e) introducing only a portion of the third effluent into the fourth column to produce a fourth effluent; (f) allowing the fourth effluent to pass through a mass spectrometer..

Methods, apparatus, and system for mass spectrometry

A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments.
The Massachusetts Institute Of Technology

Intermittent mass spectrometer inlet

An intermittent sample inlet device and methods for use of the intermittent sample inlet device are described that include an orifice plate with an entrance orifice and a rotating skimmer with a skimmer orifice, where the rotating skimmer is disposed between the orifice plate and a vacuum chamber wall. The rotating skimmer rotates so that the skimmer orifice intermittently aligns with the entrance orifice and allows an ion sample to pass through to a mass analyzer..
Smiths Detection Inc.

Cascaded-signal-intensifier-based ion imaging detector for mass spectrometer

A detector system for a mass spectrometer comprises: a metal channel dynode (mcd) comprising at least one perforated metal plate configured to receive the exiting ions and eject electrons in response; a plurality of electron-to-photon converters arranged in a parallel stacked configuration, each such converter comprising a substrate plate having a phosphor coating on a first face; and an electrode film disposed on the phosphor coating; at least one photocathode, each of the at least one photocathode disposed between a respective pair of the plurality of electron-to-photon converters; an optical detector optically coupled a last one of the electron-to-photon converters; and at least one direct current power supply configured to apply, in operation, a respective bias electrical potential to the mcd and each of the electrode films and photocathodes.. .
Thermo Finnigan Llc

High-voltage power unit and mass spectrometer using the power unit

An excessive overshoot preventing unit (16) is connected to a loop in which a command voltage vf according to a difference between: a voltage obtained by dividing an output voltage vout as a high voltage; and a control voltage v cont set from the outside is obtained and fed back to each of drive circuits (3 and 5) of a positive voltage generating unit (2) and a negative voltage generating unit (4). The excessive overshoot preventing unit (16) clamps the command voltage vf at a voltage value according to the control voltage vcont.
Shimadzu Corporation

Adjustment mechanism

A magnetic adjustment mechanism 100 comprising a chamber 10, an element 12 pivotally mounted within the chamber 10 and comprising a magnetic portion 14, and a magnetic actuator 18 arranged outside the chamber 10 to allow magnetic coupling with the magnetic portion 14 of the element 12 such that movement of the magnetic actuator 18 causes an adjustment of the position of the element 12. The adjustment mechanism 100 may be used within a vacuum chamber of a mass spectrometer to control the position of a moveable element from outside the chamber..
Thermo Fisher Scientific (bremen) Gmbh

Mass spectrometer

The objective of the present invention is to improve the robustness, sensitivity, and maintainability of a mass spectrometer to which a liquid chromatograph can be connected. This mass spectrometer includes: an ion source; a mass spectrometry unit; a plurality of flat plates used as electrodes having openings through which ions can be introduced to the mass spectrometer from an orthogonal direction along an ion introduction axis; a porous member provided between the mass spectrometry unit and the plurality of flat plates; and a mechanism for feeding gas to the plurality of flat plates for the side opposite from the ion introduction direction; the plurality of flat plates being disposed under atmospheric pressure, and the plurality of electrodes being set at a temperature higher than room temperature..
Hitachi High-technologies Corportion

Mass spectrometer

A closed-loop ion guide 1 is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. Ions are injected into the closed-loop ion guide 1 and may make several circuits of the closed-loop ion guide 1 before being ejected from the ion guide 1.
Micromass Uk Limited

Systems for separating ions and neutrals and methods of operating the same

A mass spectrometer system includes a pulsed ion source configured to generate ionized molecules and neutral molecules. The system also includes a first enclosure coupled in flow communication with the pulsed ion source.
Morpho Detection, Llc

Frequency scan linear ion trap mass spectrometry

An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an rf frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the rf to x and y electrodes.. .
Academia Sinica

Interface for an atmospheric pressure ion source in a mass spectrometer

The invention relates to a mass spectrometer having an ion source region at substantially atmospheric pressure in which ions are formed from a liquid sample. The mass spectrometer further has an interface for transmitting the formed ions from the ion source region into a vacuum region which is held at a pressure level substantially below the atmospheric pressure and where the formed ions are further processed.
Bruker Daltonics, Inc.

Ionizer and mass spectrometer

In the ionizer of the present invention, a stream of gas spouted from a nozzle (18) of a dart ionization unit (10) vaporizes and ionizes the components in a sample (25). Gaseous sample-component molecules which have not been ionized by that process are subsequently ionized by a reaction with a reactant ion produced by a corona discharge generated from a needle electrode (20).
Public University Corporation Yokohama City Univer Sity

Mass spectrometer

A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider.
Micromass Uk Limited

Mass spectrometer device and method using scanned phase applied potentials in ion guidance

An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser.
Micromass Uk Limited

Zero voltage mass spectrometry probes and systems

The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer).
Purdue Research Foundation



Mass Spectrometer topics:
  • Mass Spectrometer
  • Spectrometer
  • Mass Spectrometry
  • Spectrometry
  • Downstream
  • Coordinates
  • Quantitative
  • Chromatograph
  • Data Processing
  • Biomolecule
  • Data Acquisition
  • Electrical Signal
  • Data Compression
  • Fragmentation
  • Irradiation


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