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This page is updated frequently with new Mass Spectrometer-related patent applications. Subscribe to the Mass Spectrometer RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometer RSS RSS



Date/App# patent app List of recent Mass Spectrometer-related patents
07/30/15
20150214021 
 Mass spectrometer interface patent thumbnailnew patent Mass spectrometer interface
A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport.
Ionics Mass Spectrometry Group Inc.


07/30/15
20150214019 
 Rf power supply for a mass spectrometer patent thumbnailnew patent Rf power supply for a mass spectrometer
The present invention provides a radio frequency (rf) power supply in a mass spectrometer. The power supply provides an rf signal to electrodes of a storage device to create a trapping field.
Thermo Finnigan Llc


07/30/15
20150211924 
 Device for preventing intensity reduction of optical signal, optical emission spectrometer, optical instrument, and mass spectrometer including the same patent thumbnailnew patent Device for preventing intensity reduction of optical signal, optical emission spectrometer, optical instrument, and mass spectrometer including the same
A device for a device for preventing the intensity reduction of an optical signal, an optical emission spectrometer, an optical instrument, and a mass spectrometer including the same are provided. The device for preventing the intensity reduction includes a shielding filter which has a mesh structure capable of blocking rf electromagnetic waves radiated from a plasma field for a wafer processing, is installed in the front of an optical window of an optical emission spectrometer for measuring the plasma field from an emission spectrum image of the plasma field, and collects charging particles passing through the mesh..
Industry-academic Cooperation Foundation Yonsei University


07/23/15
20150206728 
 Mass spectrometer and method patent thumbnailMass spectrometer and method
A measurement state in a mass spectrometer device is determined so that the measurement method for the next round of measurement can be automatically determined. The mass spectrometer device (1) is provided with: a first calculation unit (6) that calculates the total amount of ion in a mass spectrum; a second calculation unit (6) that calculates the half-value width of a representative peak selected from peaks appearing in the mass spectrum; and a control unit (7) that determines the measurement method for use in the next round of measurement on the basis of the total amount of ion and the half-value width of the representative peak..
Hitachi High-technologies Corporation


07/23/15
20150206726 
 Method and system for the quantitative chemical speciation of heavy metals and other toxic pollutants patent thumbnailMethod and system for the quantitative chemical speciation of heavy metals and other toxic pollutants
This invention relates to systems and methods for measuring quantitatively multiple species or heavy metals, including mercury, and other toxic pollutants. More specifically, the systems and methods of the invention allows for determination of the analytes even at very low concentration, through concentration on a collection interface, desorption and analysis by mass spectrometry.

07/23/15
20150204838 
 Engine exhaust gas sampling for mass spectrometer real time oil consumption measurement patent thumbnailEngine exhaust gas sampling for mass spectrometer real time oil consumption measurement
An engine oil consumption measuring system includes a multi-cylinder engine with an exhaust system positioned in a test cell. A sampling probe has an end positioned in the exhaust system to receive exhaust.
Caterpillar Inc.


07/23/15
20150204827 
 Gas analysis system comprising a gas spectrometer equipped with a micro-reflectron patent thumbnailGas analysis system comprising a gas spectrometer equipped with a micro-reflectron
Said mass spectrometer (tofms) being arranged in the volume of at least one substrate and comprising a micro-reflectron (r) arranged between the source (ms1, ms2) and the free-flight zone (ms4), a wall (r1) of said micro-reflectron comprising a layer made from a resistive material designed to be polarised between at least two regions so as to create a continuous electrostatic field gradient in said reflectron.. .

07/09/15
20150194295 
 Assembly for use in a vacuum treatment process patent thumbnailAssembly for use in a vacuum treatment process
An assembly for use in a vacuum treatment process, the assembly including a process changer 1. Gas analysis apparatus to sample and analyse the gas composition within the chamber 1 is provided.
Uab Nova Fabrica


07/02/15
20150187558 
 Pulse-burst assisted electrospray ionization mass spectrometer patent thumbnailPulse-burst assisted electrospray ionization mass spectrometer
The present invention relates to a mass spectrometer system, which combines laser desorption with pulse bursts comprising a train of ultrashort pulses and electrospray ionization. The pulse separation between individual pulses within the pulse burst is selected such that transient phenomena on an irradiated sample do not fully relax between individual pulses.
Imra America, Inc.


07/02/15
20150187557 
 Electron source for an rf-free electronmagnetostatic electron-induced dissociation cell and use in a tandem mass spectrometer patent thumbnailElectron source for an rf-free electronmagnetostatic electron-induced dissociation cell and use in a tandem mass spectrometer
An electron source for electron-induced dissociation in an rf-free electromagnetostatic cell for use installation in a tandem mass spectrometer is provided. An electromagnetostatic electron-induced dissociation cell may include at least one magnet having an opening disposed therein and having a longitudinal axis extending through the opening, the magnet having magnetic flux lines associated therewith, and an electron emitter having an electron emissive surface comprising a sheet, the emitter disposed about the axis at a location relative to the magnet where the electron emissive surface is substantially perpendicular to the magnetic flux lines at the electron emissive surface..
State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Osu


07/02/15
20150187556 

Method to generate data acquisition mass spectrometry


A process for automatically creating a measurement method suitable for plasma ion source mass spectrometry, including: semi-quantitatively measuring all elements in the sample that affect the measurement; determining a plasma condition based on the total concentration of the semi-quantitatively measured elements; for each of the semi-quantitatively measured elements, estimating signal strengths of the element and an interference component in the sample to be measured and based on the resultant estimates, estimating the concentration of the element; and, based on the estimated signal strengths of the elements and the interference components and the estimated concentrations of the elements, creating at least one mass spectrometry method including at least one of: (1) a plasma condition; (2) an internal standard to be added to the sample; (3) a tuning condition for the collision/reaction cell; (4) a mass-to-charge ratio used in the mass spectrometer; and (5) an integration time used in the mass spectrometer.. .
Agilent Technologies, Inc.


07/02/15
20150187555 

Ion optical system for mass spectrometer


A mass spectrometer includes: a plasma generation device for generating plasma for ionizing an introduced sample; an interface device for drawing the plasma into vacuum; an ion lens device for extracting and inducing ions as an ion beam from the plasma; a collision/reaction cell for removing an interference ion from the ion beam; a mass analyzer or filter for allowing a predetermined ion in the ion beam from the collision/reaction cell to pass along a first axis based on a mass-to-charge ratio; an ion detector for detecting the ion; an ion deflection device before the mass analyzer, and also an ion deflection device between the mass analyzer and the ion detector. The mass spectrometer reduces background noises in a mass analyzer by removing neutral particles from the ion beam without reducing the measurement sensitivity on ions to be analyzed as much as possible..
Agilent Technologies, Inc.


07/02/15
20150187554 

Mass spectrometer


Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer..
Hitachi High-technologies Corporation


07/02/15
20150187550 

Electron multiplier for mass spectrometer


A secondary electron multiplier includes: a conversion dynode for emitting a secondary electron in response to an incident ion; a plurality of dynodes configured to have multi-stages from second to final stages for receiving the secondary electron; and a first voltage applying device for applying a first negative voltage to the conversion dynode and sequentially dividing the first negative voltage to apply to each of the second-stage and subsequent dynodes, wherein the secondary electron multiplier is configured to sequentially multiply the emitted secondary electron by the second-stage and subsequent dynodes. In the secondary electron multiplier, any of the second-stage and subsequent dynodes have a second voltage applying device for applying a second negative voltage.
Agilent Technologies, Inc.


07/02/15
20150186595 

Bioinformatics platform for high-throughput identification and quantification of n--glycopeptide


The present invention relates to a more efficient and accurate method for the identification and quantification of comparatively low abundant glycopeptides, compared with general peptides, using mass spectrum obtained by using high resolution mass spectrometer. Therefore, the method of the present invention can be effectively used for the techniques for identification of biotherapeutics and diagnosis of cancer or disease by screening glycopeptide, the disease marker (biomarker), from various samples..
Korea Basic Science Institute


06/25/15
20150179421 

Ion optical element


An ion optical element that may be used as an ion guide in a mass spectrometer, as a reflectron in a time-of-flight mass spectrometer, as an ion mobility drift tube in an ion mobility spectrometer, or as a collision cell or reaction cell in a mass spectrometer. The ion optical element has an inner tube made of a first ceramic material within an outer ceramic tube made of a second ceramic material.
Waters Technologies Corporation


06/25/15
20150179419 

Method for mass spectrometer with enhanced sensitivity to product ions


A mass spectrometry method comprises: introducing a first portion of a sample of ions including precursor ions comprising a first precursor-ion mass-to-charge (m/z) ratio into a first mass analyzer; transmitting the precursor ions from the first mass analyzer to a reaction or fragmentation cell such that a first population of product ions are continuously accumulated therein over a first accumulation time duration; initiating release of the accumulated first population of product ions from the reaction or fragmentation cell; continuously transmitting the released first population of product ions from the reaction cell to a second mass analyzer; transmitting a portion of the released first population of product ions comprising a first product-ion m/z ratio from the second mass analyzer to a detector; and detecting a varying quantity of the product ions having the first product-ion m/z ratio for a predetermined data-acquisition time period after the initiation of the release.. .
Thermo Finnigan Llc


06/18/15
20150170896 

Mass spectrometer


A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider.
Micromass Uk Limited


06/18/15
20150170894 

Collision cell


A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis.
Thermo Fisher Scientific (bremen) Gmbh


06/11/15
20150162178 

Ion trap mass spectrometer using cold electron souce


The present invention relates to an ion trap mass spectrometer using a cold electron source, in a production of a portable mass spectrometer, in which a microchannel plate (mcp) module is used, initial electrons are induced by injecting ultraviolet photons emitted from an ultraviolet diode to a front surface of the mcp module, electron beams amplified from the electrons are amplified using a channeltron electron multiplier (cem), the amplified electron beams are accurately adjusted and injected into an ion trap, thus increasing the amplification rate, and since a quadrupole field is used as an ion filter which returns the initially injected electrons to the inside of an ion trap mass separator, the ionization rate increases.. .
Korean Basic Science Institute


06/11/15
20150162175 

Methods for isolation and decomposition of mass spectrometric protein signatures


A method of analyzing a liquid mixture comprising protein or peptide molecules mixed with other molecules comprises: passing a portion of the mixture through a liquid chromatograph so as to elute the molecules; transferring the eluted portions of the molecules to an ion source of a mass spectrometer so as to generate ions comprising a plurality of ion species therefrom; transferring the generated ion species to a mass analyzer for detection thereby; generating a respective record of the intensity-versus-time variation of each of a plurality of the detected ion species; identifying and distinguishing a set of ion species corresponding to the ions generated from the eluted portion of the protein or peptide analyte molecules based on the records of the intensity-versus-time variation; and performing at least one additional operation on ions of one or more of the distinguished ion species generated from the protein or peptide analyte molecules.. .
Thermo Finnigan Llc


06/04/15
20150155154 

Miniature time-of-flight mass spectrometer


A miniature time-of-flight mass spectrometer (tof-ms) was developed for a nasa/astid program beginning 2008. The primary targeted application for this technology is the detection of non-volatile (refractory) and biological materials on landed planetary missions.
C&e Research, Inc.


06/04/15
20150155153 

Orthogonal acceleration system for time-of-flight mass spectrometer


An orthogonal pulse accelerator for a time-of-flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension.
Perkinelmer Health Sciences, Inc.


06/04/15
20150155150 

Mass spectrometer


A mass spectrometer is disclosed comprising a first ion trap or ion guide, a single ion mobility spectrometer or separator stage and a second ion trap or ion guide arranged downstream of the ion mobility spectrometer or separator. A mode of operation includes passing ions from said first ion trap or ion guide to said device and onwards to said second ion trap or ion guide and then passing at least some of said ions or at least some fragment, daughter, product or adduct ions derived from said ions from said second ion trap or ion guide onwards to said first ion trap or ion guide.
Micromass Uk Limited


06/04/15
20150155149 

Cryogenic collisional cooling cell


A mass spectrometer is disclosed comprising a cooling cell 4 for cooling ions so as to reduce their kinetic energy. The cooling cell 4 comprises: a chamber for receiving the ions or for generating the ions therein, wherein said chamber is formed from walls defining a substantially enclosed region; and a cooling jacket 16 surrounding said chamber, wherein said cooling jacket 16 is arranged and configured to contain a cooling fluid and so as to remove heat from one or more walls of the chamber.
Micromass Uk Limited


06/04/15
20150155148 

Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system


Provided is an ionization apparatus including: a holder configured to hold a sample; a probe configured to determine a part to be ionized of the sample held by the holder; an extract electrode configured to extract ionized ions of the sample; a liquid supply unit configured to supply liquid to a part of a region of the sample; and a unit configured to apply a first voltage between the probe and the extract electrode, in which the first voltage is pulse-modulated.. .
Canon Kabushiki Kaisha


06/04/15
20150155147 

Targeted analysis for tandem mass spectrometry


A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection tof device that separates ions into packets in accordance with their m/z.
Thermo Fisher Scientific (bremen) Gmbh


06/04/15
20150155132 

Mass spectrometer and mass image analyzing system


The mass spectrometer has a chamber in which a sample is disposed, an irradiation unit for emitting particles to the sample, and an extraction electrode which leads secondary ions emitted from the sample to a mass spectrometry unit, in which the irradiation unit switches a first mode of emitting primary ions for causing the secondary ions to be emitted from the sample and a second mode of emitting particles containing water molecules to be made to adhere to the sample and emits the particles to the sample.. .

06/04/15
20150153221 

Method for detecting a perturbation by hysteretic cycle using a nonlinear electromechanical resonator and device using the method


A method is provided for detecting a perturbation with respect to an initial state, of a device comprising at least one resonant mechanical element exhibiting a physical parameter sensitive to a perturbation such that the said perturbation modifies the resonance frequency of the said resonant mechanical element. A device is provided for detecting a perturbation by hysteretic cycle comprising at least one electromechanical resonator with nonlinear behaviour and means for actuation and for detection of the reception signal via a transducer so as to analyse the response signal implementing the method.
Centre National De La Recherche Scientifique


05/28/15
20150144784 

Exponential scan mode for quadrupole mass spectrometers to generate super-resolved mass spectra


A novel scanning method of a mass spectrometer apparatus is introduced so as to relate by simple time shifts, rather than time dilations, the component signal (“peak”) from each ion even to an arbitrary reference signal produced by a desired homogeneous population of ions. Such a method and system, as introduced herein, is enabled in a novel fashion by scanning exponentially the rf and dc voltages on a quadrupole mass filter versus time while maintaining the rf and dc in constant proportion to each other.
Thermo Finnigan Llc


05/28/15
20150144783 

Glycopeptide analyzer


The same sample s is analyzed using an ion-trap (it) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (tof) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an it mass spectrum and a tof mass spectrum from the measured results.
Shimadzu Corporation


05/28/15
20150144782 

Systems, devices, and methods for connecting a chromatography system to a mass spectrometer


The invention provides interfaces between analytical instruments, e.g., between chromatography systems and mass spectrometers. In an exemplary embodiment, an ion source is provided for connecting a carbon dioxide-based chromatograph device to a mass spectrometer.
Waters Technologies Corporation


05/28/15
20150144781 

Method and controlling the supply of ions


A method for controlling the supply of ions from a liquid chromatograph through an ion source into a mass spectrometer. The ion source is foreseen to be either an electrospray ionization sources or an impaction spraying ion sources.
Micromass Uk Limited


05/28/15
20150144779 

Electron impact ion source with fast response


A closed electron impact ion source with overall opening area of less than 30 mm2 is employed for direct and pulsed extraction into a time-flight mass spectrometer in order to enhance sensitivity and immunity to chemical noise of oil and fumes of the vacuum system. For compatibility with dual stage gc×gc separation, the source may contain an inert liner surrounded by an isothermal cage of thermally conductive material.
Leco Corporation


05/28/15
20150144778 

Data independent acquisition of product ion spectra and reference spectra library matching


Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows.

05/28/15
20150144777 

Multiple solid phase micro-extraction thermal desorption ionization device, mass spectrometer and analytical mass spectrometry


A multiple solid phase microextraction (m-spme) thermal desorption ionization device which desorbs an analyte and moves it into an entry of a mass spectrometer for mass spectrometry analysis is provided. The device has a charge producing unit, a heating unit and a sampling unit.
National Sun Yat-sen University


05/21/15
20150142361 

High dynamic range detector correction algorithm


Systems and methods are provided to perform dead time correction. An observed ion count rate is obtained using a non-paralyzable detection system of a mass spectrometer.
Dh Technologies Development Pte. Ltd.


05/21/15
20150136968 

Systems and methods for using interleaving window widths in tandem mass spectrometry


Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.


05/14/15
20150129758 

Systems and methods for sequencing peptides by mass spectrometry


The number of atoms present in an ion of a molecule is identified using a mixture of different forms of the molecule. A mass spectrometer analyzes a mixture of at least two forms of the molecule using one or more ion scans producing a mass spectrum.

05/14/15
20150129757 

Systems and methods for using variable mass selection window widths in tandem mass spectrometry


Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.

05/07/15
20150126403 

Method of identifying proteins in human serum indicative of pathologies of human lung tissues


A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known to have non-small cell lung cancers and asthma, as diagnosed by a physician. Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer.
Cancer Prevention And Cure, Ltd


05/07/15
20150123354 

Sealing surface, in particular for a vacuum chamber of a mass spectrometer and manufacturing such a sealing surface


A sealing surface, in particular for a vacuum chamber of a mass spectrometer and an associated manufacturing process, has non-circular shapes and can be produced with low effort. The sealing surface has circumferential cracks, being produced by erosion or jet machining or indentation-forming.
Vacutec Hochvakuum- & Präzisionstechnik Gmbh


05/07/15
20150123012 

Sample plate using maldi-tof mass spectrometer and manufacturing the sample plate


A sample plate in use with a maldi-tof (matrix-assisted laser desorption ionization time-of-flight) mass spectrometer. The sample plate is usable for the mass spectrometry of a polymeric material on the order of several hundreds of da and a method of manufacturing the same sample plate.
Industry-academic Cooperation Foundation, Yonsei University


05/07/15
20150122991 

Sample transferring mass cytometry


In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (icp) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion.
Fluidigm Canada Inc.


05/07/15
20150122986 

Mass spectrometer with laser spot pattern for maldi


The invention relates to mass spectrometers with an ion source, comprising a uv laser system for mass spectrometric analyses with ionization of analyte molecules in a sample by matrix-assisted laser desorption, which, with very low energy losses, can produce a spatially distributed spot pattern with several intensity peaks of equal height, thus making it possible to achieve an optimum degree of ionization of analyte ions for any task. Such a spot pattern can be generated from the uv beam with high transverse coherence, using a combination of a lens array and a lens, provided that the lens array satisfies a mathematical condition for separation of the micro-lenses from each other (pitch) and their focal length.
Bruker Daltonik Gmbh


05/07/15
20150121993 

Dispersive liquid-liquid microextraction detecting n-nitrosoamines


The dispersive liquid-liquid microextraction (dllme) method of detecting n-nitrosoamines (nas) is a dllme performed with a xylene extraction solvent and a methanol disperser solvent. The microextraction is preferably performed by a programmable array logic (pal) auto-sampler.
King Fahd University Of Petroleum And Minerals


04/30/15
20150115151 

Ion mobility spectrometer


A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the ims.
Leco Corporation


04/23/15
20150111787 

Digital microfluidic chips for automated hydrogen deuterium exchange (hdx) ms analysis


Described herein is a digital microfluidic droplet generator (dmdg) and a microfluidic platform for processing material introduced into the dmdg. The combination is particularly suited for hydrogen/deuterium exchange and mass spectrometer (hdx-ms) processing and analysis of membrane proteins..
The Regents Of The University Of California


04/23/15
20150111300 

Apparatus for pretreating biological samples, and mass spectrometer equipped with same


A clinical laboratory apparatus includes a pretreating apparatus having a high separation capability and providing high data reproducibility and reliability and a mass spectrometer is provided which executes fully automatic processing from pretreatment to detection. The pretreating apparatus that includes a cartridge for holding an extraction agent for solid-phase extraction, a pressure-loading unit for applying a pressure load to any cartridge mounted on the solid-phase extraction cartridge-retaining unit, a receiving tray mechanism for receiving a sample extracted from the cartridge, and a liquid-level sensor for detecting liquid levels in the receiving tray as well as in the cartridge, conducts feedback control for the pressure-loading unit to open its pressure release valve upon the liquid-level sensor detecting that the liquid level in the receiving tray mechanism has reached a preset liquid-level position..
Hitachi High-technologies Corporation


04/23/15
20150108348 

Mass spectrometer


The larger an m/z to be adjusted, the wider a peak width which represents change in intensity in relation to change in voltage. This allows voltage step size to be increased during a search for an optimum voltage without overlooking a maximum intensity.
Shimadzu Corporation


04/23/15
20150108347 

Method and apparatus to desolvate ions at high pressure and to improve transmission and contamination in the coupling of mass spectrometers and mobility spectrometers with ionizers


A method and apparatus that operate at near atmospheric pressure are described to simultaneously (i) desolvate the droplets produced by an ions source (including electrospray sources), to (ii) separate the surviving droplets from the analyte ions, to (iii) increase the transmission of ions through the inlet of an analyzer, while (iv) preventing the passage through said inlet of neutral contaminants and low mobility species and droplets that could potentially impair the operation of the analyzer, which include mass spectrometers and ion mobility spectrometers. In the present invention, contaminant low mobility species are efficiently deflected away from the analyzer inlet by a sweep flow.
Sociedad Europea De Analisis Diferencial De Movilidad


04/23/15
20150108342 

Extraction and detection system and method


An apparatus, system and method for the continuous flow extraction, collection and analysis of small amounts of energetic substance/s and their reacted/unreacted residue/s in real time are provided. The apparatus includes an agitator that generates a particulate material from a surface.

04/23/15
20150108341 

Mass spectrometer and mass spectrometry


A portable mass spectrometer that is carried to a sampling site to conduct analysis incorporates measures against erroneous operation. To prevent erroneous operation, when a measurement sample cannot be accurately analyzed because of contamination in the measurement sample, a criterion for aborting the sample measurement is provided and mass spectrometer control maintenance is performed.
Hitachi High-technologies Corporation


04/23/15
20150108340 

Switch circuit, mass spectrometer, and control switch circuit


Provided is a switch circuit that includes plural mos switches connected in series in such a manner that the source of one element is connected to the drain of another between high voltage and a system ground and that switches a connection state between the high voltage and the system ground, the switch circuit including: a mos switch 101 the source of which is connected to the system ground among the plural mos switches; a mos switch 102 the source of which is connected to the drain of the mos switch 101 in a shared manner and the drain of which is connected to the high voltage side among the plural mos switches; a mos switch 103 the drain of which is connected to the gate of the mos switch 102 in a shared manner; and a resistor 104 that is connected in parallel between the gate and the source of the mos switch 102.. .

04/23/15
20150107349 

Mud logging depth and composition measurements


A sample that includes formation content from a subsurface formation and other sample constituents is obtained while the sample is in close proximity to the subsurface formation. While downhole, the formation content is separated from the other sample constituents by passing the sample through an oil-wet porous plate, a water-wet porous plate, or through both plates, and analyzed.
Schlumberger Technology Corporation


04/23/15
20150107331 

Integrated hydrocarbon analysis


Petroleum or other hydrocarbon samples can be analyzed in parallel by 1) gc-field ionization time of flight mass spectrometer (gc-fi-tof ms) and 2) two dimensional gas chromatography (2d-gc) equipped with a flame ionization detector (fid). The combined techniques allow for improved quantitative characterization of the compounds within a hydrocarbon sample.
Exxonmobil Research And Engineering Company


04/16/15
20150102219 

Tandem quadrupole mass spectrometer


Prior to multiple reaction monitoring (mrm) measurement condition optimization, an analysis operator prepares, for each precursor ion of an objective compound, two lists on a product-ion selection condition setting screen 200, i.e. A list 203 which shows ions to be preferentially selected as product ions for which the optimization needs to be performed and a list 202 which shows ions to be excluded from the optimization.
Shimadzu Corporation


04/16/15
20150102217 

Introduction of ions into ion cyclotron resonance cells


The invention relates to a method and a device for introducing ions into an icr cell of fourier transform ion cyclotron resonance mass spectrometers, in particular with a reduced the magnetron orbit. The invention is based on applying at least one gated dc voltage to a mantle electrode of the icr cell prior to the excitation of the cyclotron motion such that injected ions are deflected inside the icr cell in at least one radial direction..
Bruker Daltonik Gmbh


04/16/15
20150102215 

Collision cell multipole


mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion.
Thermo Fisher Scientific (bremen) Gmbh


04/16/15
20150102213 

Electrode device with pre- and/or postfilters and manufacturing method therefor, as well as a mass spectrometer with such an electrode device


A method manufactures a multipolar electrode device, in particular a multipole for use in a mass spectrometer, wherein the electrode device includes at least one main filter and at least one pre- and/or postfilter. The electrode blanks are separated in several sections for producing the pre- and/or postfilters, which are thereby maintained by a holder in a constant relative position to each other.
Vacutec Hochvakuum- & PrÄzisionstechnik Gmbh


04/09/15
20150097115 

Method and a combined linear ion trap and quadrupole mass filter


An apparatus for a mass spectrometer comprises: a set of four rod electrodes defining an ion occupation volume therebetween having entrance and exit ends, at least one of the rod electrodes having a slot passing therethrough; first and second ion optics disposed adjacent to the entrance and exit ends, respectively; a voltage supply system; and at least one supplemental electrode disposed at least partially within the at least one slot, wherein the voltage supply system is configured so as to supply a radio-frequency (rf) voltage, a direct-current (dc) filtering voltage and an oscillatory dipole resonant ejection voltage across members of the set of rod electrodes and so at to supply a secondary ion-trapping rf voltage and a secondary dc filtering voltage to the at least one supplemental electrode and to supply dc voltages across the rod electrodes and each of the first and second ion optics.. .
Thermo Finnigan Llc


04/09/15
20150097114 

Excitation of reagent molecules withn a rf confined ion guide or ion trap to perform ion molecule, ion radical or ion-ion interaction experiments


A mass spectrometer is disclosed comprising an rf ion guide or ion trap and a device arranged and adapted to supply a reagent gas within the rf ion guide or ion trap. The mass spectrometer further comprises a photo-ionisation device and a control system arranged and adapted: (i) to cause first ions to fragment or dissociate within the rf ion guide or ion trap to form second ions and neutral molecules; and (ii) to cause the photo-ionisation device to photo-ionise and/or photo-excite the reagent gas to form reagent ions, excited species or radical species.
Micromass Uk Limited


04/09/15
20150097113 

Modulation of instrument resolution dependant upon the complexity of a previous scan


Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor.
Dh Technologies Development Pte. Ltd.


04/02/15
20150090874 

Method and apparatus to provide parallel acquisition of mass spectrometry/mass spectrometry data


A system and method for acquisition of mass spectrometry data is configured to provide a stream of charged particles (e.g., from an analytical volume). A primary mass spectrometer (e.g., time-of-flight mass spectrometer) may be used to separate charged particles of the stream of charged particles based on their mass-to-charge ratio and detect the charged particles in a mass-to-charge spectrum.
Ulvac-phi, Incorporated


04/02/15
20150090872 

Mass spectrometer


A hardware module which operatively carries out a method of compressing mass spectral data, the method comprising: receiving a first signal output from an ion detector of a mass spectrometer; processing the first signal to a digital signal at an output being data frame types representative of the first signal output; temporarily storing the data frame types in a memory block and reading a data frame from the memory block and determining its data frame type and according to its data frame type compressing the data frame according to one or more compression algorithms to generate a compressed data output stream.. .
Micromass Uk Limited


03/19/15
20150080233 

Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry


A method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided. In certain embodiments, the method comprises: labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (sims) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set.
The Board Of Trustees Of The Leland Stanford Junior University


03/19/15
20150076366 

Mass spectrometric ion storage device for different mass ranges


The invention relates to devices and methods for the storage of ions in mass spectrometers. The invention proposes the generation and superposition of two multipole fields of different order, independent of each other, in an rf multipole rod system.
Bruker Daltonik Gmbh


03/19/15
20150076341 

Method of mass spectrometry and a mass spectrometer


The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas..
Micromass Uk Limited


03/19/15
20150076338 

Mass spectrometer, control system and methods of operating and assembling a mass spectrometer


A mass spectrometer and methods for controlling a mass spectrometer are provided. In an exemplary embodiment, the mass spectrometer includes a plurality of discrete functional modules, each operable to perform a predetermined function of the mass spectrometer, wherein the modules are individually addressable and connected in a network.
Micromass Uk Limited


03/12/15
20150068279 

Electro-enhanced solid-phase microextraction method


The electro-enhanced solid-phase microextraction (ee-spme) method involves extraction that is performed with an spme fiber, preferably made of polydimethylsiloxane (pdms), in the presence of an applied electric potential for a predetermined period of time. Polar analytes are extracted onto the fiber, which is the stationary phase.
King Fahd University Of Petroleum And Minerals


03/05/15
20150066421 

Method for following degassing rate by measuring partial pressures measured bymass spectrometry


Where m denotes the set of reference atomic masses, pi denotes the partial pressures for the atomic masses measured by the mass spectrometer, the coefficients αi denote preset weighting coefficients associated with each partial pressure pi, and n denotes a maximum atomic mass for which the partial pressure pi can be measured by the mass spectrometer.. .

03/05/15
20150066387 

Substance identification method and mass spectrometer using the same


Ms1 and ms2 measurements of fractionated samples are performed. Based on the identification results and the s/n ratios of the ms1 peaks, an identification probability estimation model showing a relationship between the cumulative number of ms1 peaks and the number of ms1 peaks successfully identified through the ms2 measurements and identifications performed in ascending order of s/n ratio is created.
Shimadzu Corporation


03/05/15
20150064793 

Method of discerning substitution of carbohydrate esters


A method of testing for discerning substitution of carbohydrate ester includes the step of providing a predetermined amount of a solution. Further, the method also includes adding ammonium hydroxide and sodium borohydride to the solution.
Biologistics Llc


03/05/15
20150064739 

Analyzer


An analyzer includes a pretreatment device and a mass spectrometer. The pretreatment device includes a solid phase extraction mechanism.
Hitachi High-technologies Corporation


03/05/15
20150060687 

Ion deflector for a mass spectrometer


There is provided an ion deflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The ion deflector includes an electric field inducer arranged so as to establish at least one electrostatic field capable of deflecting ions travelling substantially along a first intended path of travel so as to travel substantially along a second intended path of travel..
Bruker Chemical Analysis Bv


02/26/15
20150053854 

Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum


Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry..
Wayne State University


02/26/15
20150053853 

Plume collimation for laser ablation electrospray ionization mass spectrometry


In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume.
The George Washington University


02/19/15
20150048255 

Ion source for mass spectrometer and producing analyte ion stream


An ion source for a mass spectrometer and a method of ionizing a sample are disclosed. A droplet generator is configured to emit a stream of analyte droplets, which are ionized upon impact with a target, thus forming an ion stream.
Waters Technologies Corporation (a Delaware Corp)


02/19/15
20150048245 

Ion optical system for maldi-tof mass spectrometer


An ion accelerator for a time-of-flight mass spectrometer includes a pulsed ion accelerator positioned proximate to a sample plate and having an electrode that is electrically connected to the sample plate. An accelerator power supply generates an accelerating potential on the ion accelerator electrode that accelerates a pulse of ions generated from the sample positioned on the sample plate.
Virgin Instruments Corporation


02/12/15
20150041641 

Mass spectrometer


A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample.
Hitachi High-technologies Corporation


02/05/15
20150039233 

Method for near real time surface logging of a hydrocarbon or geothermal well using a mass spectrometer


An automatic method for providing geological trends and real time mapping of a geological basin using a mass spectrometer. The method provides information from a mass spectrometer on fluid samples from a wellbore into a geochemical surface well log with graphical tracks in real time.
Selman And Associated, Ltd


02/05/15
20150037606 

Electrolytic copper foil, cleaning fluid composition and cleaning copper foil


An electrolytic copper foil includes a copper foil body; and a iia-group metal adhered to a surface of the copper foil body, wherein a signal strength of the iia group metal is greater than 0.1% based on a signal strength of copper element as 100% analyzed by a secondary ion mass spectrometer. The present invention also provides a method for cleaning copper foil and a cleaning fluid composition which is used in the cleaning method..
Chang Chun Petrochemical Co., Ltd.


02/05/15
20150034821 

Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system


Provided is an ionization apparatus including: a holder configured to hold a sample; a probe configured to determine a part to be ionized of the sample held by the holder; an extract electrode configured to extract ionized ions of the sample; a liquid supply unit configured to supply liquid to a part of a region of the sample; and a unit configured to apply a first voltage between the probe and the extract electrode, in which the first voltage is pulse-modulated.. .
Canon Kabushiki Kaisha


02/05/15
20150034820 

Continuous operation high speed ion trap mass spectrometer


The present disclosure discusses a system and method for continuous operation of an ion trap mass spectrometer. The described system does not introduce ions into the ion trap in distinct trapping phase, rather the described system continuously injects ions into the ion trap while continuously scanning out the ions.
Mini-mass Counseling


02/05/15
20150034819 

Multiple channel detection for time of flight mass spectrometer


An ion detector for a time of flight mass spectrometer is disclosed comprising a single microchannel plate which is arranged to receive ions and output electrons. The electrons are directed onto an array of photodiodes which directly detects the electrons.
Micromass Uk Limited


02/05/15
20150034818 

Discontinuous atmospheric pressure interface


A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample.
Purdue Research Foundation


02/05/15
20150034816 

Interface for mass spectrometry apparatus


There is provided an interface for use in sampling ions in a mass spectrometer, the interface being arranged for receiving a quantity of ions from an ion source and forming more than one ion beam therefrom, each ion beam being directed along a respective desired pathway.. .
Bruker Chemical Analysis Bv


02/05/15
20150034814 

Maldi imaging and ion source


An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm.
Micromass Uk Limited


02/05/15
20150034813 

Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis


A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as hydrogen-deuterium exchange.
Micromass Uk Limited


02/05/15
20150034812 

Multi-dimensional chromatograph system


In a two-dimensional lc system configured to introduce components trapped in a trap column during a fractionation period t into a second-dimension column, separate components, and then detect the components using a mass spectrometer, a data collection unit receives a signal which indicates timing to delimit the fractionation period t, determines the first data item in the fractionation period t, adds measurement start point identification information to the first data item, and stores all the data in a data storage unit. A two-dimensional chromatogram creation unit recognizes the first data item in each fractionation period t from the read data, and create a two-dimensional chromatogram by aligning data so that the first data items will be aligned at the top along an abscissa..
Shimadzu Corporation


01/29/15
20150028743 

Device for supplying voltage to the cathode of a mass spectrometer


A simplified device for voltage supply of the cathode of a mass spectrometer comprises a push-pull transformer, wherein, apart from the normal rectifier diodes (7, 9), a controlled rectifier (8, 10) is provided. The gate of the first transistor (8) is connected to the second output (30), and the gate of the second transistor (10) is connected to the first output (32) of the transformer.
Inficon Gmbh


01/29/15
20150028221 

Methods of ion source fabrication


A method of ion source fabrication for a mass spectrometer includes simultaneously forming aligned component portions of an ion source using direct metal laser fusing of sequential layers. The method can further include forming the component portions on a base plate made from a ceramic material by applying fused powder to the base plate to build the component portions thereon..
Hamilton Sundstrand Corporation


01/29/15
20150028198 

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction and having a space therebetween, the x direction being orthogonal to y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the x direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length..
Thermo Fisher Scientific (bremen) Gmbh


01/29/15
20150028197 

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction, the x direction being orthogonal to y, characterized in that the mirrors are not a constant distance from each other in the x direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer.
Thermo Fisher Scientific (bremen) Gmbh




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Mass Spectrometer topics: Mass Spectrometer, Spectrometer, Mass Spectrometry, Spectrometry, Downstream, Coordinates, Quantitative, Chromatograph, Data Processing, Biomolecule, Data Acquisition, Electrical Signal, Data Compression, Fragmentation, Irradiation

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