|| List of recent Mass Spectrometer-related patents
| Atmospheric pressure ionization mass spectrometer|
In an atmospheric pressure ionization source using an esi or the like having a desolvation pipe with one end opening serving as an ion-drawing port, a drying-gas supplying port for supplying a drying gas against the ion-drawing direction is provided below the ion-drawing port, i.e. At a position opposite to the side where a nozzle for spraying a liquid sample into an atmospheric pressure atmosphere is located, as viewed from the ion-drawing port.
| Ion mobility spectrometer|
A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the ims.
| Mass spectrometers comprising accelerator devices|
A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
| Lens for electron capture dissociation, fourier transform ion cyclotron resonance mass spectrometer comprising the same and method for improving signal of fourier transform ion cyclotron resonance mass spectrometer|
A lens for electron capture dissociation may include: a first electrode and a second electrode spaced apart from each other and arranged along a first direction; and a third electrode and a fourth electrode spaced apart from each other and arranged along a second direction perpendicular to the first direction. The first electrode and the second electrode may be disposed in a space in which a magnetic field is formed in the first direction and trap electrons.
| Multi-nozzle chip for electrospray ionization in mass spectrometers|
The invention involves electrospray ionization of dissolved substances at atmospheric pressure in the ion source of a mass spectrometer. A chip with a multitude of spray nozzles is proposed, where each individual spray nozzle is surrounded by several sheath gas nozzles, preferably in a symmetric arrangement, for the jet-like introduction of a sheath gas.
| Tubular membrane gas and volatile compounds sampler for fluid introduction at atmospheric to high pressure|
A high-transmittance sampler of dissolved gases and volatile organic compounds (voc) is described that is based upon a thin polymer membrane with tubular geometry. Very high hydrostatic pressures are maintained by surrounding the polymer tube or coating with sintered material.
|Method and apparatus for monitoring ion lens connections|
This technology is directed to a method and apparatus for monitoring or testing defects associated with an ion lens connected within a mass spectrometer. In some implementations, the testing mechanism monitors a connection of one or more ion lenses configured in the mass spectrometer to determine if voltage is effectively applied to the ion lens.
|Mass spectrometer having an external detector|
A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space.
|Orthogonal acceleration system for time-of-flight mass spectrometer|
An orthogonal pulse accelerator for a time-of-flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension.
|Ionization within ion trap using photoionization and electron ionization|
A mass spectrometer is disclosed. The mass spectrometer may include an ion trap configured to trap and analyze an ionized sample.
|Differential mobility spectrometer and methods thereof|
An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions.
A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser.
|Identifying the occurrence and location of charging in the ion path of a mass spectrometer|
A method is described for identifying the occurrence and location of charging of ion optic devices arranged along the ion path of a mass spectrometer. The method includes repeatedly performing a sequence of introducing a beam of discharge ions to a location on the ion path, and subsequently measuring the intensities of opposite-polarity sample ions delivered to a mass analyzer, with the discharge ions being delivered to a location further downstream in the ion path at each successive sequence..
|Method for cleaning an atmospheric pressure chemical ionization source|
Build-up of surface contamination within an atmospheric pressure chemical ionization (apci) source of a mass spectrometer (ms) is reversed by switching the apci polarity to the opposite setting used for analyte ionization after the analytes have been ionized and measured. A solvent or mixture of solvents is passed through the ion source during the opposite-polarity operation.
|Capillary microextractor of volatiles (cmv)|
A capillary microextractor of volatiles (cmv) allows the sampling of diagnostic volatiles that can be an explosive, explosive taggant, drug, poison, decomposition products thereof, a mixture of chemicals comprising an odor signature determined from detector dog trials, or volatile organic compounds indicative of a disease or other medical condition. The cmv has a thermally stable housing with orifices to allow the contact of a gas that contains one or more diagnostic volatiles with an absorbent that extracts and concentrates the diagnostic volatiles.
|Mass spectrometry (ms) identification algorithm|
A system includes a gas chromatograph configured to determine experimental chromatographic data including retention times associated with samples. The system also includes a mass spectrometer configured to determine experimental mass spectral data associated with samples.
|Method for fabricating stable-isotope-labeled target peptide fragment in mass spectrometry|
An object of the present invention is to provide a method for producing a stable isotope-labeled target peptide fragment in mass spectrometry, which achieves inexpensive and convenient production. As a solution to attain the object, the stable isotope-labeled target peptide fragment in mass spectrometry is produced using a method comprising the steps of: expressing a dna conjugate in a system having a stable isotope-labeled amino acid to thereby prepare a stable isotope-labeled protein, wherein the dna conjugate comprises: a tandemly linked dna in which two or more dnas encoding one or more types of target peptide fragments are linked in tandem; and a dna encoding a peptide fragment for concentration measurement; subjecting the stable isotope-labeled protein to fragmentation treatment with trypsin to prepare a stable isotope-labeled peptide fragment for concentration measurement and stable isotope-labeled target peptide fragments; quantifying the stable isotope-labeled peptide fragment for concentration measurement using a liquid chromatograph-tandem mass spectrometer (lc/ms/ms); and calculating the concentration of the stable isotope-labeled target peptide fragment of each type from the quantification value of the stable isotope-labeled peptide fragment for concentration measurement..
Methods and materials relate to degradable detergents. The degradable detergents have degradable linkages that are cleaved when subjected to elevated temperature and/or reduced pressure.
|Mass spectrometer ion trap having asymmetric end cap apertures|
An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode.
|Tandem ion trapping arrangement|
A mass spectrometer is disclosed comprising a first storage ion trap arranged upstream of a high performance analytical ion trap. According to an embodiment, ions are simultaneously scanned from both the first and second ion trap.
|Mass spectrum noise cancellation by alternating inverted synchronous rf|
A mass spectrometer comprising a controller configured to generate an rf signal to be applied to an electrode during the mass scan, wherein the electrode generates, based on the rf signal, an electric field to be applied to sample ions during a mass scan; an ion detector configured to detect sample ions passing through the electric field and generate a corresponding ion detection signal; and a sampling circuit configured to sample the ion detection signal; wherein the controller is configured to adjust a phase of the at least one rf signal relative to a sample timing of the sampling circuit and average successive mass scans to cancel a portion of the rf signal present in the ion detection signal.. .
|Methods and systems for applying end cap dc bias in ion traps|
A mass spectrometer for analyzing a sample utilizing an ion trap comprises an entrance end cap defining an entrance aperture configured to receive the sample entering the ion trap; a ring electrode defining a ring cavity configured to generate, based on a radio frequency (rf) voltage applied to the ring electrode, an electric field configured to trap the sample received through the entrance aperture; an exit end cap defining an exit aperture configured to receive sample ions exiting the ion trap; and an end cap controller configured to generate a bias control voltage for applying a dc bias potential to at least one of the entrance end or the exit end cap, wherein a value of the bias control voltage is based on an operational parameter of the mass spectrometer.. .
A mass spectrometer having a multi-stage differential pumping system with an ion lens provided in a partition wall separating a second intermediate vacuum chamber and a third intermediate vacuum chamber, the incircle radii of ion guides and the size of the opening of the ion lens are determined so that the circumferential edge of the opening is located outside the circumferential surface of a virtual tubular body straightly connecting the incircle at the rear edge of the second ion guide in the front stage and the incircle at the front edge of the third ion guide in the rear stage. Although the ion lens is located in between, the radio-frequency electric field created by the second ion guide can be effectively connected to the radio-frequency electric field created by the third ion guide through the opening of the ion lens..
|Systems and methods for calibrating mass spectrometers|
Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer.
|Chemical analysis instrument with multi-purpose pump|
A mass spectrometer for analyzing a sample may include an analysis chamber for analyzing the sample and a first vacuum pump operably connected to the analysis chamber, wherein the first vacuum pump operates to create a first vacuum state. The mass spectrometer may also include a sample-preparation chamber operably connected to the analysis chamber and a second vacuum pump that operates to create a second vacuum state, wherein the first vacuum state is a lower pressure than the second vacuum state.
|Looped ionization source|
Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions.
|Multiple channel detection for time of flight mass spectrometer|
An ion detector for a time of flight mass spectrometer is disclosed comprising a single microchannel plate which is arranged to receive ions and output electrons. The electrons are directed onto an array of photodiodes which directly detects the electrons.
|Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer|
Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows msn experiments to be performed on very basic mass spectrometers, even those without secondary mass analyzers and/or collision cells.
|Segmented planar calibration for correction of errors in time of flight mass spectrometers|
An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions.
|Chromatograph mass spectrometer|
Sequential identification numbers are automatically provided and undisplayed, constant, unique numbers are assigned to each event registered in an analysis condition setting table 100. Since correspondence information between the identification numbers and the unique numbers changes due to the reassignment of identification numbers when an event is deleted from the table, event identification numbers for each compound are changed by referring to the correspondence information on a compound information table.
In order to solve a problem in a mass spectrometry that a distribution of an emitted ion and a substance distribution on the measurement object surface are different from each other, which is due to a shaded portion of a irregular surface which falls under a shadow of primary beam, a primary ion optical system of the present apparatus includes a deflection unit configured to deflect the primary ion in such a manner that the primary ion intersects a flight space of the secondary ion in the course of flight.. .
|Method and apparatus for mass spectrometry|
A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (mr tof) mass spectrometry..
|Techniques for automated performance maintenance testing and reporting for analytical instruments|
Techniques are described for performing performance maintenance on a mass spectrometer. Pre-maintenance testing is performed that automating execution of a test sequence in response to a first user interface selection.
|Tandem mass spectrometer and mass spectrometric method|
An ion trap is provided between a collision cell and a time-of-flight mass separator. During a time period in which precursor ions derived from the same compound are selected with a quadrupole mass filter, a collision energy is changed from one to another.
|Detection of membrane protein-therapeutic agent complexes by mass spectrometry|
According to the present invention, there is provided a method of detecting a complex comprising a membrane protein bound to a therapeutic agent by mass spectrometry. The method comprises: (a) providing a solution comprising a detergent micelle in which said complex is contained; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the complex is released from the micelle; (d) ionising the complex; (e) resolving the ionised complex using the mass analyser; and (f) detecting the resolved complex using the detector.
|Discontinuous atmospheric pressure interface|
A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample.
|Mass spectrometer with bypass of a fragmentation device|
A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer..
A collision cell for a mass spectrometer arranged to receive ions for fragmentation in a chamber and comprising an activation ion generator configured to irradiate the received ions with activation ions of the same polarity as the received ions. The activation ion generator is preferably a plasma generator, configured to generate a plasma comprising the activation ions..
|Time-of-flight mass spectrometer|
A thin metal plate and two prismatic-bar-shaped metal members that are parallel to each other are alternately and repeatedly stacked, and the stack is sandwiched between two thick metal plates. Each contact surface is bonded to the counterpart surface by diffusion bonding to form an integrated multilayer body.
|Differentially pumped dual linear quadrupole ion trap mass spectrometer|
The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (lqit) mass spectrometers with differentially pumped vacuum chambers..
|Quadrupole mass spectrometer with enhanced sensitivity and mass resolving power|
A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a function of time and spatial displacement in the beam cross-section of a quadrupole mass filter via an arrayed detector.
A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells.
|Photo-dissociation of proteins and peptides in a mass spectrometer|
A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.. .
|Mass spectrometer and mass spectrometric method|
A mass spectrometry using helium as cooling gas is performed to obtain a first mass spectrum (s1), and another mass spectrometry using argon, which is heavier than helium, as cooling gas is performed to obtain a second mass spectrum for the same sample (s2). Due to the difference between the two gases in terms of the effect of promoting dissociation of modifications, an ion peak originating from a target compound from which all the modifications have been dissociated will appear with a higher intensity on the second mass spectrum.
|Correction of asymmetric electric fields in ion cyclotron resonance cells|
The invention relates to a method and a device for optimization of electric fields in measurement cells of fourier transform ion cyclotron resonance mass spectrometers. The invention is based on the rationale that asymmetric electric fields with uniformly or non-uniformly perturbed field axes can appear in ion cyclotron resonance cells and therefore the axis of the magnetron orbit can become radially displaced.
|Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers|
Mass spectrometry cells include one or more interleaved magnetostatic and electrostatic lenses. In some examples, the electrostatic lenses are based on electrical potentials applied to magnetostatic lens pole pieces.
|Method and apparatus for improving ion transmission into a mass spectrometer|
An ion transfer device for transferring ions emerging from an electrospray ion source at atmosphere to a vacuum chamber includes an inner surface in the shape of a diverging conical duct. The ion transfer device has an entrance aperture for positioning proximate the exit port of the electrospray ion source emitter, the entrance aperture receiving the electrosprayed ions from the exit port of the electrospray ion source emitter at atmosphere, the diverging conical duct being an electrode toward which the ions migrate and having an exit aperture with an inner diameter larger than an inner diameter of its entrance aperture, the exit aperture enclosed in the vacuum chamber, the diverging conical duct transporting the ions from atmosphere to vacuum.
|Aperture gas flow restriction|
A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture.
|Ion guide with orthogonal sampling|
A mass spectrometer is disclosed comprising a rf ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the rf ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar..
|Fragmentation methods for mass spectrometry|
Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ecd) and positron capture dissociation (pcd), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ecd often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable.
|Method for predicting whether a cancer patient will not benefit from platinum-based chemotherapy agents|
A testing method for identification whether a cancer patient is a member of a group or class of cancer patients that are not likely to benefit from administration of a platinum-based chemotherapy agent, e.g., cisplatin, carboplatin or analogs thereof, either alone or in combination with other non-platinum chemotherapy agents, e.g., gemcitabine and paclitaxel. This identification can be made in advance of treatment.
|Function switching with fast asynchronous acquisition|
A method of analysing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the state or mode of the mass spectrometer.
|Arrangement for a removable ion-optical assembly in a mass spectrometer|
Presented is a mass spectrometer comprising an ion path along which ions are transported between different sections of the mass spectrometer, and further comprising an arrangement with a receptacle being located along the ion path in the mass spectrometer and a complementary mount for carrying a removable ion-optical assembly, such as a carrier of electrodes for a maldi ion source, wherein the mount can be removed from and reinserted into the receptacle in a plane approximately perpendicular to an ion path axis.. .
|Timing device and method|
The present invention provides a timing device, especially a timing device for use in mass spectrometers, for example tof mass spectrometers, for processing trigger signal data containing a trigger signal indicating the occurrence of a trigger event, the timing device having: a trigger signal deserialiser configured to receive trigger signal data containing a trigger signal indicating the occurrence of a trigger event as serial data and to output the trigger signal data as parallel data, and wherein suitably the timing device has a processing means configured to process trigger signal data outputted by the trigger signal deserialiser as parallel data.. .
|Methods for the detection of biologically relevant molecules and their interaction characteristics|
Methods for the detection of biologically relevant molecules that comprise concentrating such molecules into microscopic holes in a sheet of chemically inert material, restricting the openings, and measuring the electric current through the holes or the fluorescence near the hole openings. The electric current or fluorescence will change as the molecules diffuse out of the holes, providing a measure of the diffusion rate and thereby detecting the presence and characteristics of the molecules.
|High pressure mass spectrometry systems and methods|
Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
|Compact mass spectrometer|
Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
|Method for analyzing halogen oxoacids|
To quantitatively analyze halogen oxoacids such as bromic acid and perchloric acid, an hplc/ms in which a mass spectrometer is connected to the outlet of a column of a high performance liquid chromatograph (hplc) is used, and by using a reverse-phase column having an ion exchange function as the column, as well as a mixed liquid of an ammonium formate buffer solution and acetonitrile as the mobile phase, gradient analysis in which the concentration of ammonium formate in ammonium formate/acetonitrile is increased is performed. Thereby, a common hplc/ms apparatus configuration using no suppressor makes it possible to appropriately separate various halogen oxoacids and other components contained in a sample and to detect them at high sensitivity..
|Tandem mass spectrometer and tandem mass spectrometry method|
The invention relates to a tandem mass spectrometer comprising an ionisation source (1) that can produce ions; a mass analyser comprising an ion trap (2) arranged in such a way as to receive ions from the ion source and detection means that can detect ions leaving the ion trap according to the mass m to load z (m/z) ratio thereof; ion activation means for activating ions that can fragment at least some of the ions trapped in the ion trap; and coupling means arranged between the ion trap and said ion activation means. According to the invention, the ion activation means consist of a glow discharge lamp (4) that can generate a light beam oriented towards the ion trap (2), said light beam being electromagnetic radiation in the vacuum ultraviolet wavelength range with photon energies of between 8 ev and 41 ev in such a way as to fragment at least some of the ions trapped in the ion trap (2)..
|Method for the detection of incorrect deposition on a maldi sample support|
The invention relates to a method for the detection of incorrect deposition on a maldi sample support with several separate sample sites, where after the preparation on the sample support, an area located between two sample sites is sampled with a desorption laser, and a signal of an ion detector in a mass spectrometer is acquired in temporal relation to the sampling. The signal is examined for the presence of a signal which indicates incorrect deposition.
|Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry|
A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.. .
|Imaging mass spectrometer and method of controlling same|
An imaging mass spectrometer capable of reducing the dependence of the resolution of a projection image on mass is offered. Also, a method of controlling this spectrometer is offered.
|Compositions, methods, and kits for quantifying target analytes in a sample|
A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known quantity of a second calibrator, and potentially comprising a target analyte. The first known quantity and the second known quantity are different, and wherein the first calibrator, the second calibrator, and the target analyte are each distinguishable in the single sample by mass spectrometry.
|Ion trap quadrupole mass filter|
An ion trap mass spectrometer is provided, including: an electron emitter; an ion trap storing ions generated by ionization resulting from an impact with electrons emitted from the electron emitter; a secondary ion filter for blocking out secondary ions generated due to ions selectively released by the ion trap; and a detector detecting ions selectively released from the ion trap, wherein the electron emitter, the ion trap, the secondary ion filter, and the ion detector are arranged on the same axis, so that a pure mass spectrum can be measured by excluding the secondary ions which are causes of background noise signals in the procedure of detection of the ions by the ion trap mass spectrometer.. .
|Method and system of identifying a sample by analysing a mass spectrum by the use of a bayesian inference technique|
A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured data set from a sample using a mass spectrometer, deconvoluting the measured data set by bayesian inference to produce a family of plausible deconvoluted data sets, inferring an underlying deconvoluted data set from the family of plausible deconvoluted data sets and using the underlying deconvoluted data set to identify and/or characterise the sample..
A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider.