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Mass Spectrometer patents

      

This page is updated frequently with new Mass Spectrometer-related patent applications.




 High pressure mass resolving ion guide with axial field patent thumbnailHigh pressure mass resolving ion guide with axial field
A mass spectrometer is disclosed comprising a first mass filter comprising a plurality of electrodes and a first device arranged and adapted to generate an axial force which drives at least some ions axially through or along the first mass filter and a quadrupole mass filter or mass analyser arranged downstream of the mass filter.. .
Micromass Uk Limited


 Mass spectrometer patent thumbnailMass spectrometer
Methods and apparatus for operating a mass spectrometer are described. In various aspects, ions of a mass range of interest may be mass-selectively ejected from an accumulation ion trap into a multi-ion trap structure.
Dh Technologies Development Pte Ltd.


 Multi-reflecting time-of-flight mass spectrometer with axial pulsed converter patent thumbnailMulti-reflecting time-of-flight mass spectrometer with axial pulsed converter
Apparatuses (41, 91, 111, 115, 121, 151) and methods (31) for time-of-flight mass spectrometry providing effective pulsed conversion of continuous ion beams into pulsed ion packets is disclosed. Bunching of energetic continuous ion beams forms ion packets, which are filtered by a subsequent isochronous energy filter (49, 79, 81-84, 110).
Leco Corporation


 Ion source for mass spectrometry patent thumbnailIon source for mass spectrometry
Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling.
Dh Technologies Development Pte. Ltd.


 Data independent acquisition of product ion spectra and reference spectra library matching patent thumbnailData independent acquisition of product ion spectra and reference spectra library matching
Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor.
Eth Zürich


 Mass spectrometry method, mass spectrometry , and mass spectrometric data processing program patent thumbnailMass spectrometry method, mass spectrometry , and mass spectrometric data processing program
In a mass spectrometric method of the invention, a mass spectrometer (2) is used having a mass separation unit (231, 234) before and after a collision cell (232) for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum.
Shimadzu Corporation


 Plasma generator using dielectric resonator patent thumbnailPlasma generator using dielectric resonator
A dielectric resonator is excited at its natural resonant frequency to produce a highly uniform electric field for the generation of plasma. The plasma may be used in a optical or mass spectrometer..
Radom Corporation


 Device for mass spectrometry patent thumbnailDevice for mass spectrometry
A device for mass spectrometry in continuous operation can be equipped with a focused electron beam source or laser radiation source. It can further include a vacuum chamber, a stage for placing the specimen, and an ion beam column with a plasma source for producing a primary ion beam and a secondary ion mass spectrometer for secondary ion analysis.
Tescan Brno, S.r.o.


 Integrated sample processing for electrospray ionization devices patent thumbnailIntegrated sample processing for electrospray ionization devices
Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one esi emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one esi emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one esi emitter thereby preferentially directing analyte molecules out of the at least one esi emitter.
The University Of North Carolina At Chapel Hill


 Mass spectrometer vacuum interface method and apparatus patent thumbnailMass spectrometer vacuum interface method and apparatus
A mass spectrometer vacuum interface can include a skimmer apparatus having a skimmer aperture and an internal surface. A method of operating the mass spectrometer vacuum interface can include establishing an outwardly directed flow along the internal surface of the skimmer apparatus..
Thermo Fisher Scientific (bremen) Gmbh


Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis

A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as hydrogen-deuterium exchange.
Micromass Uk Limited

Multiplex enzyme assay using mass spectrometer-based flow cytometer

The present invention generally relates to methods for the detection of enzymes using elemental analysis.. .
Fluidigm Canada Inc.

An electrostatic ion trap mass spectrometer utilizing autoresonant ion excitation and methods of using the same

Methods of operation of electrostatic ion trap mass spectrometers in which ions are autoresonantly driven at selected higher integer (>2) multiples of ion oscillation frequencies are provided. Excitation at multiples higher than the fundamental or double the fundamental ion oscillation frequency significantly improves both signal intensity and mass resolution.
Rutgers, The State University Of New Jersey

Process and measuring an organic solid sample by glow discharge spectrometry

A system and a process for measuring, by glow discharge spectrometry, the elemental and/or molecular chemical composition of an organic solid sample (10). The sample (10) is positioned so as to seal a glow discharge plasma reactor (2), a gaseous mixture including at least one inert gas and gaseous oxygen is injected into the reactor (2), the concentration of gaseous oxygen being between 0.1% and 15% by weight of the gaseous mixture, an electric discharge of radiofrequency type is applied to the electrodes of the plasma reactor (2) in order to generate a glow discharge plasma, and the solid sample (10) is exposed to the plasma so as to etch an erosion crater in the solid sample (10); at least one signal representative of an ionized species of negative charge is selected and measured using a mass spectrometer (4)..
Horiba Jobin Yvon Sas

Microwave cavity resonator detector

An ion detector system for a mass spectrometer is disclosed comprising a first device arranged and adapted to receive ions and emit or output first electrons and a microwave cavity resonator arranged and adapted to deflect the first electrons onto a first detector.. .
Micromass Uk Limited

Studies on real time ozone layer depletion monitoring using the negative ion mode of ion mobility spectrometry / atmospheric pressure ionization mass spectrometry (neg. mode ims/apims) in upper and lower atmosphere

The present invention provides a capability of ion mobility spectrometry/atmospheric pressure ionization mass spectrometry (ims/ms) in the negative ion mode for ozone detection and methods for ozone layer depletion monitoring in laboratory environment. Ammonium hydroxide vapors, as a dopant chemical, introduced to the inlet system of the ims/ms interfaced with the reaction sphere enables ozone ionized to be o3−.

Determining device for hydrocarbon emissions of motors

A determination device for hydrocarbon emissions of a thermal engine including an inspection probe for removing a sample volume from a liquid, a measurement channel for conducting the sample volume via an ion source apparatus to a broadband measurement apparatus that is configured to determine a spectrum to be measured in one step, wherein the ion source apparatus is configured for soft ionization and the measurement apparatus forms an intensity signal sequence across the mass spectrum and is configured as a simultaneously measuring “time-of-flight” detector or as a “double-focusing sector field mass spectrometer in mattauch-herzog geometry.”. .
Verwaltungsgesellschaft Für Emissionsanalyse Ug (haftungsbeschränkt)

Mass spectrometer

The mass spectrometer (1) provides an ionization chamber (11) therein with: a probe (15) having a sample to be measured flow path (155) for spraying a sample to be measured; and a standard sample flow path (255) for spraying a standard sample used for the calibration of the mass-to-charge ratio of the mass spectrum into the ionization chamber. The standard sample is intermittently introduced into the ionization chamber via a pulse valve (216).
Shimadzu Corporation

Ambient infrared laser ablation mass spectrometry (airlab-ms) with plume capture by continuous flow solvent probe

A new experimental setup for spatially resolved ambient infrared laser ablation mass spectrometry (airlab-ms) that uses an infrared microscope with an infinity-corrected reflective objective and a continuous flow solvent probe coupled to a fourier transform ion cyclotron resonance mass spectrometer is described. The efficiency of material transfer from the sample to the electrospray ionization emitter was determined using glycerol/methanol droplets containing 1 mm nicotine and is ˜50%.
The Regents Of The University Of California

Systems and methods for using interleaving window widths in tandem mass spectrometry

Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.

Systems and methods for acquiring data for mass spectrometry images

Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample.
Dh Technologies Development Pte. Ltd.

Cryofocused sampling of volatiles from air using peltier-assisted capillary microextraction

A cmv sampling device includes a thermoelectric cooler, a vacuum pump, and one or more holders for one or more capillary microextractor of volatiles (cmv) tubes. The holder thermally contacts the thermoelectric cooler and the vacuum pump is fluidly connected to the cmv tube.
The Florida International University Board Of Trustees

Systems and methods for using variable mass selection window widths in tandem mass spectrometry

Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor.
Dh Technologies Development Pte. Ltd.

Method for mass spectrometric examination of gas mixtures and mass spectrometer therefor

A method includes parallel or serial ionization of a gas mixture by activating at least two ionization devices operating using different ionization procedures, and/or by ionizing the gas mixture in a detector to which the gas mixture and ions and/or metastable particles of an ionization gas are fed. The method also includes detecting the ionized gas mixture in the detector for the mass spectrometric examination thereof.
Carl Zeiss Microscopy Gmbh

Particles containing detectable elemental code

The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (fc-ms) (fig. 1)..
Fluidigm Canada Inc.

Vacuum pump and mass spectrometer

A vacuum pump comprises: a first pump stage; a second pump stage provided downstream of the first pump stage; a first suction port provided on a suction side of the first pump stage; and a second suction port provided downstream of the first pump stage and communicating with the second pump stage. The first pump stage includes a siegbahn pump portion suitable for a small exhaust volume, and a turbo-molecular pump portion.
Shimadzu Corporation

Quasi-planar multi-reflecting time-of-flight mass spectrometer

A multi-reflecting, time-of-flight (mr-tof) mass spectrometer including two quasi-planar electrostatic ion mirrors extended along drill direction (z) and formed of parallel electrodes, separated by a field free region. The mr-tof includes a pulsed ion source to release ion packets at a small angle to x-direction which is orthogonal to the drill direction z.
Leco Corporation

Novel diagnostic gastric cancer

This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in n-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the n-glycan as compared to normal persons, n-glycan structures identified using the changes in n-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis..
Korea Advanced Institute Of Science And Technology

Coupling intermediate pressure regions

A method is disclosed for coupling a first chamber of a mass spectrometer or ion mobility spectrometer containing a first gas and a second chamber containing a second gas. The method comprises providing an intermediate region between the first and second chambers that is operated at a lower pressure to substantially prevent or reduce ingress of the first gas into the second chamber and/or of the second gas into the first chamber..
Micromass Uk Limited

Systems and methods for analyzing an extracted sample using an immiscible extraction solvent

The invention generally relates to systems and methods for analyzing an extracted sample using an immiscible extraction solvent. In certain embodiments, the invention provides a system for analyzing an analyte in a sample.
Purdue Research Foundation

Rapid lc mapping of cov values for selexion technology using mrm-triggered mrm functionality

Mrm triggered mrm, where the triggered mrm transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary mrm transitions are received and stored together with a mobility device parameter value for each transition as an mrm cycle list.
Dh Technologies Development Pte. Ltd.

Tandem quadrupole mass spectrometer

A dwell time calculation table (51a) showing a correspondence relation between a cid gas pressure inside a collision cell (31) and a dwell time for data collection is stored in a processing condition parameter memory (51) of a controller (50). In the table (51a), as the cid gas pressure becomes higher, the dwell time becomes longer.
Shimadzu Corporation

Electrostatic mass spectrometer with encoded frequent pulses

A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
Leco Corporation

Systems and methods for ion isolation

A mass spectrometer includes a radio frequency ion trap and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap and supply an isolation waveform to the radio frequency ion trap.
Thermo Finnigan Llc

Systems and methods for ion isolation using a dual waveform

A mass spectrometer includes a radio frequency ion trap; and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap; supply a first isolation waveform to the radio frequency ion trap for a first duration, and supply a second isolation waveform to the radio frequency ion trap for a second duration.
Thermo Finnigan Llc

Systems and methods for delivering liquid to an ion source

Methods and systems for delivering a liquid sample to an ion source are provided herein: in various aspects, the methods and systems described herein can utilize the flow provided by an lc pump(s) to drive a calibration fluid to an ion source of a mass spectrometer system. In various aspects, methods and systems described herein can additionally or alternatively be placed upstream of an lc column for providing an elution gradient of a plurality of solvents, without requiring a plurality of pumps and/or separate mixing elements..
Dh Technologies Development Pte. Ltd.

Auxiliary gas inlet

There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a matrix assisted laser desorption ionisation (“maldi”) ion source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.. .
Micromass Uk Limited

Auxiliary gas inlet

There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a continuous ionisation source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.. .
Micromass Uk Limited

Pressure driven microfluidic injection for chemical separations

Methods that allow independently applied pressures to a bge reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer..
The University Of North Carolina At Chapel Hill

Mass spectrometer and mass spectrometry method

A mass spectrometer including an ionization source including an esi probe (201), an esi power source (24), a corona needle (202) and an apci power source (24); an ionization condition storage section (41) for storing a plurality of ionization conditions related to the liquid sample, set by an analysis operator, with the ionization conditions differing from each other in the value of the esi voltage or/and the value of the apci voltage; a mass spectrometry executer (43) for conducting a mass spectrometry for an ion generated from the liquid sample using each of the plurality of ionization conditions; and a mass spectrometry result selector (44) for selecting, for each of the one or plurality of components, a mass spectrometry result in which the ion is detected with a suitable level of intensity for an analysis, from the mass spectrometry results respectively obtained for the plurality of ionization conditions.. .
Shimadzu Corporation

Homogenization of the pulsed electric field created in a ring stack ion accelerator

A ring stacked accelerator for use in a mass spectrometer includes a plurality of ring shaped plates arranged in a stack and is electrically coupled to a voltage divider that allows a substantially homogeneous electric field to be produced when the stack is energized. The voltage divider can include resistors and capacitors, where the capacitors are chosen to compensate for parasitic capacitances experienced by the plates.
Dh Technologies Development Pte. Ltd.

Mass spectrometer

The objective of the present invention is to obtain an ms2 spectrum for each of a plurality of different ion species even when their m/z values are extremely close to each other and prevent separate setting of each ion species as the precursor ion. In the vicinity of the target m/z, a precursor-ion selection window covering a predetermined m/z range (2×Δm) is gradually shifted in predetermined steps (Δm) to define a plurality of windows as the condition of the precursor-ion selection.
Shimadzu Corporation

Ion mobility analyzer and mass spectrometer

A drift voltage generator applies voltages to a plurality of annular electrodes, respectively, so that a potential distribution φ on an ion beam axis of an accelerating electric field created within a drift region satisfies ∂2φ/∂z2>0. Trailing ions undergo a higher rate of acceleration than preceding ions, so that a compressing force acts on an ion packet in the direction of the ion beam axis.
Shimadzu Corporation

Globally optimized targeted mass spectrometry (got-ms)

Globally optimized targeted (got)-ms, combines many of the advantages of targeted detection and global profiling in metabolomics analysis, including the capability to detect unknowns, broad metabolite coverage, and excellent quantitation. A global search of precursor and product ions using a single triple quadrupole (qqq) mass spectrometer includes sim incremental scanning or incremental ms scanning performed in the mass range of 40-2000 da, followed by tandem ms/ms scanning with incremental collision energy for precursor ions to profile product ions..
University Of Washington

System for transferring ions in a mass spectrometer

A system for transporting ions includes: an ion transfer tube having an axis and an internal bore having a width and a height less than the width; and an apparatus comprising a plurality of electrodes, each having a respective ion aperture having an aperture center, the apertures defining an ion channel configured to receive the ions from the ion transfer tube and to transport the ions to an outlet end of the apparatus, wherein at least a subset of the apertures progressively decrease in size in a direction towards the apparatus outlet end, wherein the ion transfer tube is configured such that the ion transfer tube axis is non-coincident with an axis of the ion channel or such that the width dimension of the ion transfer tube bore is parallel to a plane defined by the ion transfer tube axis and the ion channel axis.. .
Thermo Finnigan Llc

Isotopic enrichment of helium-3 through glass

Disclosed is a mass selective fluid bandpass filter. This filter provides for selecting gas molecules of a specific mass from a gas sample containing molecules of two or more mass species.

Methods and systems for high speed laser surgery

The present disclosure relates to a methods and systems for high speed laser surgery. In some implementations, the combination of mid-infrared (mid-ir) laser radiation with micro-scanning technology allows for large tissue ablation rates with minimal thermally affected zones, where micro-scanning distributes the heat generated by laser surgery over a large tissue area.
Imra America, Inc.

High speed polarity switch time-of-flight spectrometer

In one aspect, a mass spectrometer is disclosed that includes a time-of-flight analyzer (tof), which comprises an accelerator stage comprising a plurality of electrodes and adapted to receive and accelerate a plurality of ions, and a drift chamber disposed downstream of said accelerator stage for receiving at least a portion of the accelerated ions. The tof analyzer further comprises a pulser coupled to the accelerator stage for applying one or more voltages to said plurality of electrodes, and a controller coupled to the pulser and adapted to cause the pulser to adjust said one or more voltages applied to the electrodes so as to configure the accelerator stage to receive and accelerate positive and negative ions during different cycles of an ion detection period..
Dh Technologies Development Pte. Ltd.

Tandem mass spectrometer and tandem mass spectrometry method

The invention relates to a tandem mass spectrometer comprising an ionization source that can produce ions; a mass analyser comprising an ion trap arranged in such a way as to receive ions from the ion source and a detector that can detect ions leaving the ion trap according to the mass to charge (m/z) ratio thereof; ion activation means for activating ions that can fragment at least some of the ions trapped in the ion trap; and coupling means arranged between the ion trap and said ion activation means. According to the invention, the ion activation means consists of a glow discharge lamp that can generate a light beam oriented towards the ion trap, said light beam being electromagnetic radiation in the vacuum ultraviolet wavelength range with photon energies of between 8 ev and 41 ev in such a way as to fragment at least some of the ions trapped in the ion trap..
Synchrotron Soleil

Method of producing a mass spectrum

A method of producing a mass spectrum from a time-varying transient signal detected in a mass spectrometer, the method comprising: performing a fourier transform of the transient signal to produce a first set of complex amplitudes wherein each of the complex amplitudes corresponds to a respective frequency of a first set of frequencies; generating a second set of complex amplitudes, wherein each of the complex amplitudes corresponds to a respective frequency of a second set of frequencies with a minimum spacing less than the inverse of the duration of the transient signal; optimizing the second set of complex amplitudes to produce an improved second set; generating a mass spectrum from at least some of the improved second set of complex amplitudes; wherein optimizing the second set of complex amplitudes to produce an improved second set of complex amplitudes is based on an objective function subject to some phase constraints.. .
Thermo Fisher Scientific (bremen) Gmbh

Mass spectrometer and mass spectrometry method

The degree of ion dissociation which occurs within a first intermediate vacuum chamber (212) maintained at a comparatively low degree of vacuum depends not only on the amount of energy of the ion but also on the size and other properties of the ion. Accordingly, a predetermined optimum level of dc bias voltage is applied to an ion guide (24) so as to create, within the first intermediate vacuum chamber (212), a dc electric field which barely induces the dissociation of an ion originating from a target compound in a sample while promoting the dissociation of an ion originating from a foreign substance which will form a noise signal in the observation of the target compound.
Shimadzu Corporation



Mass Spectrometer topics:
  • Mass Spectrometer
  • Spectrometer
  • Mass Spectrometry
  • Spectrometry
  • Downstream
  • Coordinates
  • Quantitative
  • Chromatograph
  • Data Processing
  • Biomolecule
  • Data Acquisition
  • Electrical Signal
  • Data Compression
  • Fragmentation
  • Irradiation


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