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Mass Spectrometer patents



      
           
This page is updated frequently with new Mass Spectrometer-related patent applications. Subscribe to the Mass Spectrometer RSS feed to automatically get the update: related Mass RSS feeds. RSS updates for this page: Mass Spectrometer RSS RSS


Capturing of cell fluid and analysis of its components under observation of cells and instruments for the cell fluid…

Capturing of cell fluid and analysis of its components under observation of cells and instruments for the cell fluid…

Chemical ionization with reactant ion formation at atmospheric pressure in a mass spectrometer

Chemical ionization with reactant ion formation at atmospheric pressure in a mass spectrometer

Chemical ionization with reactant ion formation at atmospheric pressure in a mass spectrometer

Gaseous sample injection valve and gaseous sample injection method using same

Date/App# patent app List of recent Mass Spectrometer-related patents
10/23/14
20140316717
 Imaging mass analysis data processing method and imaging mass spectrometer patent thumbnailImaging mass analysis data processing method and imaging mass spectrometer
If spatial measurement point intervals in imaging mass analysis data of two samples to be compared are different and the degrees of spatial distribution spreading of substances are compared, one of the data is defined as a reference, the measurement point intervals in the other of the data are redefined so as to be equalized to the reference, and a mass spectrum at each virtual measurement point set as a result of the redefinition is obtained through interpolation or extrapolation based on a mass spectrum at an actual measurement points. If the arrays of the m/z values of mass spectra are different for each sample, the m/z value positions of the mass spectrum in one of the data are defined as a reference, and the intensity values corresponding to the reference m/z values are obtained through interpolation or extrapolation for the mass spectrum of the other of the data..
10/23/14
20140315237
 Capturing of cell fluid and analysis of its components under observation of cells and instruments for the cell fluid capturing and the analysis patent thumbnailCapturing of cell fluid and analysis of its components under observation of cells and instruments for the cell fluid capturing and the analysis
A method captures cellular components from a single cell and performs mass spectrometry on the components. The method includes inserting a nanospray ionization capillary tip into a specific region of the cell under observation with a microscope.
10/23/14
20140314660
 Chemical ionization with reactant ion formation at atmospheric pressure in a mass spectrometer patent thumbnailChemical ionization with reactant ion formation at atmospheric pressure in a mass spectrometer
The invention relates to the production of water cluster ions (“hydronium clusters”) at atmospheric pressure for the chemical ionization of analyte molecules. It is proposed that a corona discharge at the taylor cone of an aqueous liquid, preferably pure or slightly acidified pure water, is used instead of corona discharges on metal tips, which have been the usual method up to now.
10/23/14
20140312255
 Gaseous sample injection valve and gaseous sample injection method using same patent thumbnailGaseous sample injection valve and gaseous sample injection method using same
The present invention relates to a gaseous sample injection valve. The gaseous sample injection valve includes a middle body injecting a fixed amount of a gaseous sample into the vacuum chamber of a mass spectrometer, the middle body being constituted by a gaseous sample injection tube, a gaseous sample discharge tube, a storage part, and a vacuum chamber connection tube; an upper body accommodating a first solenoid coil, a first plunger, and a first packing; and a lower body accommodating a second solenoid coil, a second plunger, and a second packing.
10/23/14
20140312219
 Simultaneous inorganic mass spectrometer and method of inorganic mass spectrometry patent thumbnailSimultaneous inorganic mass spectrometer and method of inorganic mass spectrometry
An inorganic mass spectrometer capable of measuring a relevant and large or the full mass spectral range simultaneously may include a suitable ion source (e.g., an icp mass spectrometer with an icp ion source), an ion transfer region, ion optics to separate ions out of a plasma beam, a mattauch-herzog type mass spectrometer with a set of charged particle beam optics to condition the ion beam before an entrance slit, and a solid state multi-channel detector substantially separated from ground potential and separated from the potential of the magnet.. .
10/23/14
20140312216
 Signal processing for mass directed fraction collection patent thumbnailSignal processing for mass directed fraction collection
A system and removing noise from a mass spectrometer signal for fraction collection is described herein.. .
10/16/14
20140306107
 Methods for predictive automatic gain control for hybrid mass spectrometers patent thumbnailMethods for predictive automatic gain control for hybrid mass spectrometers
A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising performing a survey mass analysis using a mass analyzer to measure a flux of ions having m/z ratios within said restricted range and performing a dependent mass analysis of an optimal quantity of ions having m/z ratios within said restricted range, said optimal quantity collected for a time period determined by the measured ion flux, characterized in that: the time period is determined using a corrected ion flux that accounts for one or more of: (a) imperfect restriction of collected ions to the range of m/z ratios, (b) inclusion of ions within the range of m/z ratios that are undetected by the survey mass analysis, (c) different mass analyzers used for the dependent and survey mass analyses, and (d) different ion pathways used during dependent and the survey mass analyses.. .
10/16/14
20140306106
 Method for automated checking and adjustment of mass spectrometer calibration patent thumbnailMethod for automated checking and adjustment of mass spectrometer calibration
A method for automatically checking and adjusting a calibration of a mass spectrometer having a first quadrupole (q1), a fragmentation cell and a mass analyzer comprises: introducing a sample having at least one known chemical entity; decreasing a kinetic energy so as to prevent fragmentation of ions in the fragmentation cell; optionally applying a drag field to the fragmentation cell; ionizing the at least one known chemical entity sample to generate a set of ions; performing a mass scan of the set of ions using q1; transmitting the scanned ions through q1 to and through the fragmentation cell; detecting the scanned and transmitted ions by a detector of the mass analyzer; and comparing the results with expected results. Embodiments may include automatic recalibration or notification of possible errors, need for further data processing or an analysis of system performance..
10/16/14
20140306104
 High-throughput mass-spectrometric characterization of samples patent thumbnailHigh-throughput mass-spectrometric characterization of samples
The invention relates to the characterization of samples which are located in their many hundreds up to tens or hundreds of thousands on a sample support plate in a regular pattern, a so-called array, by ionization with matrix-assisted laser desorption and mass spectrometric measurement, for example. The invention proposes that the position of the sample pattern, and thus the position of each sample in the measuring instrument, for example a mass spectrometer, should be determined by measuring at least two finely structured internal position recognition patterns, such as fine crosses.
10/16/14
20140306103
 Ion inlet for a mass spectrometer patent thumbnailIon inlet for a mass spectrometer
An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing.
10/09/14
20140302616
Method and device for determining properties of gas phase bases or acids
Properties, such as concentrations, of gas phase bases or acids of a gas sample are determined by providing a sample gas flow, which includes the bases or acids to be determined as sample constituents, as well as also interfering constituents, which are other constituents than the sample constituents. Reagent ions are provided and introduced into the sample gas flow to arrange proton transfer reaction and thereby forming sample ions.
10/09/14
20140299765
Apparatus for improved immunosuppressant drug monitoring
A liquid chromatography/mass spectrometry system includes: a source of a first mobile phase solvent consisting essentially of water plus 10 mm ammonium formate plus 0.05% formic acid; a source of a second mobile phase solvent consisting essentially of methanol plus 10 mm ammonium formate plus 0.05% formic acid; a chromatography column comprising a length of 30 mm or less of a stationary phase comprising an 8-carbon alkyl chain material bonded to 2.6 μm diameter particles having solid silica cores surrounded by porous silica outer layers; an electrospray ion source of a mass spectrometer fluidically coupled to the chromatography column so as to generate ions therefrom; a mass analyzer of the mass spectrometer operable to quantitatively detect the ions; and a programmable processor electronically coupled to the mass analyzer and comprising instructions operable to determine, based on the ion detection, a concentration of everolimus, sirolimus, tacrolimus, or cyclosporin a.. .
10/09/14
20140299763
Apparatus for elemental analysis of particles by mass spectrometry
A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
10/09/14
20140299762
Quantitative analysis method using mass spectrometer
In an ms unit, both an intensity of an ion having the highest intensity among the ions originating from a compound as the target of quantitative determination and an intensity of an isotopic ion are measured. A saturation detector determines whether or not digital data produced by an a/d converter from ion-intensity signals have reached a saturation level.
10/09/14
20140299760
Mass dependent automatic gain control for mass spectrometer
Systems and methods for automatic gain control in mass spectrometers are disclosed. An exemplary system may include a mass spectrometer, comprising a lens configured to receive a supply of ions, and a mass analyzer.
10/02/14
20140291544
Combined ion source for electrospray and atmospheric pressure chemical ionization
An ion source for a mass spectrometer comprises: a capillary having a nozzle for emitting a nebulized fluid sample; an electrode of the capillary; a high voltage power supply electrically coupled to the electrode; a second electrode disposed within or configurable to be disposed within a path of the nebulized fluid sample, wherein the capillary and capillary electrode are configurable so as to ionize the nebulized fluid sample by electrospray ionization and the second electrode is configurable so as to ionize the nebulized sample by atmospheric pressure chemical ionization and wherein the second electrode is moveable between positions such that the second electrode is and is not disposed within the path of the nebulized fluid sample, respectively.. .
10/02/14
20140291507
Multi inlet for solvent assisted inlet ionisation
A mass spectrometer is disclosed comprising a dual channel solvent assisted inlet ionisation (“saii”) interface.. .
10/02/14
20140291505
Quantification of an analyte in serum and other biological matrices
Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow.. .
10/02/14
20140291503
Mass analyser, mass spectrometer and associated methods
A mass analyser for use in a mass spectrometer. The mass analyser has a set of electrodes including electrodes arranged to form at least one electrostatic sector, the set of electrodes being spatially arranged to be capable of providing an electrostatic field in a reference plane suitable for guiding ions along a closed orbit in the reference plane, wherein the set of electrodes extend along a drift path that is locally orthogonal to the reference plane and that curves around a reference axis so that, in use, the set of electrodes provide a 3d electrostatic field region.
10/02/14
20140291501
Photo-dissociation of proteins and peptides in a mass spectrometer
A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2d or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected.
09/25/14
20140284473
Atmospheric pressure ionization mass spectrometer
In an atmospheric pressure ionization source using an esi or the like having a desolvation pipe with one end opening serving as an ion-drawing port, a drying-gas supplying port for supplying a drying gas against the ion-drawing direction is provided below the ion-drawing port, i.e. At a position opposite to the side where a nozzle for spraying a liquid sample into an atmospheric pressure atmosphere is located, as viewed from the ion-drawing port.
09/25/14
20140284472
Ion mobility spectrometer
A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the ims.
09/25/14
20140284471
Mass spectrometers comprising accelerator devices
A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
09/25/14
20140284470
Lens for electron capture dissociation, fourier transform ion cyclotron resonance mass spectrometer comprising the same and method for improving signal of fourier transform ion cyclotron resonance mass spectrometer
A lens for electron capture dissociation may include: a first electrode and a second electrode spaced apart from each other and arranged along a first direction; and a third electrode and a fourth electrode spaced apart from each other and arranged along a second direction perpendicular to the first direction. The first electrode and the second electrode may be disposed in a space in which a magnetic field is formed in the first direction and trap electrons.
09/25/14
20140284406
Multi-nozzle chip for electrospray ionization in mass spectrometers
The invention involves electrospray ionization of dissolved substances at atmospheric pressure in the ion source of a mass spectrometer. A chip with a multitude of spray nozzles is proposed, where each individual spray nozzle is surrounded by several sheath gas nozzles, preferably in a symmetric arrangement, for the jet-like introduction of a sheath gas.
09/25/14
20140283626
Tubular membrane gas and volatile compounds sampler for fluid introduction at atmospheric to high pressure
A high-transmittance sampler of dissolved gases and volatile organic compounds (voc) is described that is based upon a thin polymer membrane with tubular geometry. Very high hydrostatic pressures are maintained by surrounding the polymer tube or coating with sintered material.
09/18/14
20140266232
Method and apparatus for monitoring ion lens connections
This technology is directed to a method and apparatus for monitoring or testing defects associated with an ion lens connected within a mass spectrometer. In some implementations, the testing mechanism monitors a connection of one or more ion lenses configured in the mass spectrometer to determine if voltage is effectively applied to the ion lens.
09/18/14
20140264013
Mass spectrometer having an external detector
A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space.
09/18/14
20140264011
Orthogonal acceleration system for time-of-flight mass spectrometer
An orthogonal pulse accelerator for a time-of-flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension.
09/18/14
20140264010
Ionization within ion trap using photoionization and electron ionization
A mass spectrometer is disclosed. The mass spectrometer may include an ion trap configured to trap and analyze an ionized sample.
09/18/14
20140264009
Differential mobility spectrometer and methods thereof
An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions.
09/18/14
20140264008
Mass spectrometer
A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser.
09/18/14
20140264007
Identifying the occurrence and location of charging in the ion path of a mass spectrometer
A method is described for identifying the occurrence and location of charging of ion optic devices arranged along the ion path of a mass spectrometer. The method includes repeatedly performing a sequence of introducing a beam of discharge ions to a location on the ion path, and subsequently measuring the intensities of opposite-polarity sample ions delivered to a mass analyzer, with the discharge ions being delivered to a location further downstream in the ion path at each successive sequence..
09/18/14
20140264003
Method for cleaning an atmospheric pressure chemical ionization source
Build-up of surface contamination within an atmospheric pressure chemical ionization (apci) source of a mass spectrometer (ms) is reversed by switching the apci polarity to the opposite setting used for analyte ionization after the analytes have been ionized and measured. A solvent or mixture of solvents is passed through the ion source during the opposite-polarity operation.
09/18/14
20140260974
Capillary microextractor of volatiles (cmv)
A capillary microextractor of volatiles (cmv) allows the sampling of diagnostic volatiles that can be an explosive, explosive taggant, drug, poison, decomposition products thereof, a mixture of chemicals comprising an odor signature determined from detector dog trials, or volatile organic compounds indicative of a disease or other medical condition. The cmv has a thermally stable housing with orifices to allow the contact of a gas that contains one or more diagnostic volatiles with an absorbent that extracts and concentrates the diagnostic volatiles.
09/18/14
20140260536
Mass spectrometry (ms) identification algorithm
A system includes a gas chromatograph configured to determine experimental chromatographic data including retention times associated with samples. The system also includes a mass spectrometer configured to determine experimental mass spectral data associated with samples.
09/11/14
20140255966
Method for fabricating stable-isotope-labeled target peptide fragment in mass spectrometry
An object of the present invention is to provide a method for producing a stable isotope-labeled target peptide fragment in mass spectrometry, which achieves inexpensive and convenient production. As a solution to attain the object, the stable isotope-labeled target peptide fragment in mass spectrometry is produced using a method comprising the steps of: expressing a dna conjugate in a system having a stable isotope-labeled amino acid to thereby prepare a stable isotope-labeled protein, wherein the dna conjugate comprises: a tandemly linked dna in which two or more dnas encoding one or more types of target peptide fragments are linked in tandem; and a dna encoding a peptide fragment for concentration measurement; subjecting the stable isotope-labeled protein to fragmentation treatment with trypsin to prepare a stable isotope-labeled peptide fragment for concentration measurement and stable isotope-labeled target peptide fragments; quantifying the stable isotope-labeled peptide fragment for concentration measurement using a liquid chromatograph-tandem mass spectrometer (lc/ms/ms); and calculating the concentration of the stable isotope-labeled target peptide fragment of each type from the quantification value of the stable isotope-labeled peptide fragment for concentration measurement..
09/11/14
20140255963
Degradable detergents
Methods and materials relate to degradable detergents. The degradable detergents have degradable linkages that are cleaved when subjected to elevated temperature and/or reduced pressure.
09/11/14
20140252224
Mass spectrometer ion trap having asymmetric end cap apertures
An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode.
09/11/14
20140252223
Tandem ion trapping arrangement
A mass spectrometer is disclosed comprising a first storage ion trap arranged upstream of a high performance analytical ion trap. According to an embodiment, ions are simultaneously scanned from both the first and second ion trap.
09/11/14
20140252220
Mass spectrum noise cancellation by alternating inverted synchronous rf
A mass spectrometer comprising a controller configured to generate an rf signal to be applied to an electrode during the mass scan, wherein the electrode generates, based on the rf signal, an electric field to be applied to sample ions during a mass scan; an ion detector configured to detect sample ions passing through the electric field and generate a corresponding ion detection signal; and a sampling circuit configured to sample the ion detection signal; wherein the controller is configured to adjust a phase of the at least one rf signal relative to a sample timing of the sampling circuit and average successive mass scans to cancel a portion of the rf signal present in the ion detection signal.. .
09/11/14
20140252219
Methods and systems for applying end cap dc bias in ion traps
A mass spectrometer for analyzing a sample utilizing an ion trap comprises an entrance end cap defining an entrance aperture configured to receive the sample entering the ion trap; a ring electrode defining a ring cavity configured to generate, based on a radio frequency (rf) voltage applied to the ring electrode, an electric field configured to trap the sample received through the entrance aperture; an exit end cap defining an exit aperture configured to receive sample ions exiting the ion trap; and an end cap controller configured to generate a bias control voltage for applying a dc bias potential to at least one of the entrance end or the exit end cap, wherein a value of the bias control voltage is based on an operational parameter of the mass spectrometer.. .
09/11/14
20140252217
Mass spectrometer
A mass spectrometer having a multi-stage differential pumping system with an ion lens provided in a partition wall separating a second intermediate vacuum chamber and a third intermediate vacuum chamber, the incircle radii of ion guides and the size of the opening of the ion lens are determined so that the circumferential edge of the opening is located outside the circumferential surface of a virtual tubular body straightly connecting the incircle at the rear edge of the second ion guide in the front stage and the incircle at the front edge of the third ion guide in the rear stage. Although the ion lens is located in between, the radio-frequency electric field created by the second ion guide can be effectively connected to the radio-frequency electric field created by the third ion guide through the opening of the ion lens..
09/11/14
20140252215
Systems and methods for calibrating mass spectrometers
Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer.
09/11/14
20140250977
Chemical analysis instrument with multi-purpose pump
A mass spectrometer for analyzing a sample may include an analysis chamber for analyzing the sample and a first vacuum pump operably connected to the analysis chamber, wherein the first vacuum pump operates to create a first vacuum state. The mass spectrometer may also include a sample-preparation chamber operably connected to the analysis chamber and a second vacuum pump that operates to create a second vacuum state, wherein the first vacuum state is a lower pressure than the second vacuum state.
09/04/14
20140246581
Looped ionization source
Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions.
09/04/14
20140246579
Multiple channel detection for time of flight mass spectrometer
An ion detector for a time of flight mass spectrometer is disclosed comprising a single microchannel plate which is arranged to receive ions and output electrons. The electrons are directed onto an array of photodiodes which directly detects the electrons.
09/04/14
20140246577
Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer
Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows msn experiments to be performed on very basic mass spectrometers, even those without secondary mass analyzers and/or collision cells.
09/04/14
20140246575
Segmented planar calibration for correction of errors in time of flight mass spectrometers
An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions.
08/28/14
20140244185
Chromatograph mass spectrometer
Sequential identification numbers are automatically provided and undisplayed, constant, unique numbers are assigned to each event registered in an analysis condition setting table 100. Since correspondence information between the identification numbers and the unique numbers changes due to the reassignment of identification numbers when an event is deleted from the table, event identification numbers for each compound are changed by referring to the correspondence information on a compound information table.
08/28/14
20140239173
Mass spectrometer
In order to solve a problem in a mass spectrometry that a distribution of an emitted ion and a substance distribution on the measurement object surface are different from each other, which is due to a shaded portion of a irregular surface which falls under a shadow of primary beam, a primary ion optical system of the present apparatus includes a deflection unit configured to deflect the primary ion in such a manner that the primary ion intersects a flight space of the secondary ion in the course of flight.. .
08/28/14
20140239172
Method and apparatus for mass spectrometry
A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (mr tof) mass spectrometry..
08/28/14
20140239171
Techniques for automated performance maintenance testing and reporting for analytical instruments
Techniques are described for performing performance maintenance on a mass spectrometer. Pre-maintenance testing is performed that automating execution of a test sequence in response to a first user interface selection.
08/28/14
20140239170
Tandem mass spectrometer and mass spectrometric method
An ion trap is provided between a collision cell and a time-of-flight mass separator. During a time period in which precursor ions derived from the same compound are selected with a quadrupole mass filter, a collision energy is changed from one to another.
08/28/14
20140239169
Detection of membrane protein-therapeutic agent complexes by mass spectrometry
According to the present invention, there is provided a method of detecting a complex comprising a membrane protein bound to a therapeutic agent by mass spectrometry. The method comprises: (a) providing a solution comprising a detergent micelle in which said complex is contained; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the complex is released from the micelle; (d) ionising the complex; (e) resolving the ionised complex using the mass analyser; and (f) detecting the resolved complex using the detector.
08/21/14
20140231643
Discontinuous atmospheric pressure interface
A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample.
08/21/14
20140231642
Mass spectrometer with bypass of a fragmentation device
A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer..
08/14/14
20140224983
Ion fragmentation
A collision cell for a mass spectrometer arranged to receive ions for fragmentation in a chamber and comprising an activation ion generator configured to irradiate the received ions with activation ions of the same polarity as the received ions. The activation ion generator is preferably a plasma generator, configured to generate a plasma comprising the activation ions..
08/14/14
20140224982
Time-of-flight mass spectrometer
A thin metal plate and two prismatic-bar-shaped metal members that are parallel to each other are alternately and repeatedly stacked, and the stack is sandwiched between two thick metal plates. Each contact surface is bonded to the counterpart surface by diffusion bonding to form an integrated multilayer body.
08/14/14
20140224981
Differentially pumped dual linear quadrupole ion trap mass spectrometer
The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (lqit) mass spectrometers with differentially pumped vacuum chambers..
08/14/14
20140224980
Quadrupole mass spectrometer with enhanced sensitivity and mass resolving power
A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a function of time and spatial displacement in the beam cross-section of a quadrupole mass filter via an arrayed detector.
08/14/14
20140224978
Mass spectrometer
A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells.
08/14/14
20140224974
Photo-dissociation of proteins and peptides in a mass spectrometer
A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.. .
08/14/14
20140224973
Mass spectrometer and mass spectrometric method
A mass spectrometry using helium as cooling gas is performed to obtain a first mass spectrum (s1), and another mass spectrometry using argon, which is heavier than helium, as cooling gas is performed to obtain a second mass spectrum for the same sample (s2). Due to the difference between the two gases in terms of the effect of promoting dissociation of modifications, an ion peak originating from a target compound from which all the modifications have been dissociated will appear with a higher intensity on the second mass spectrum.
08/14/14
20140224972
Correction of asymmetric electric fields in ion cyclotron resonance cells
The invention relates to a method and a device for optimization of electric fields in measurement cells of fourier transform ion cyclotron resonance mass spectrometers. The invention is based on the rationale that asymmetric electric fields with uniformly or non-uniformly perturbed field axes can appear in ion cyclotron resonance cells and therefore the axis of the magnetron orbit can become radially displaced.


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Mass Spectrometer topics: Mass Spectrometer, Spectrometer, Mass Spectrometry, Spectrometry, Downstream, Coordinates, Quantitative, Chromatograph, Data Processing, Biomolecule, Data Acquisition, Electrical Signal, Data Compression, Fragmentation, Irradiation

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