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Mass Spectrometer patents

      

This page is updated frequently with new Mass Spectrometer-related patent applications.




 Digital waveform manipulations to produce ms<sup>n</sup> collision induced dissociation patent thumbnailDigital waveform manipulations to produce msn collision induced dissociation
A novel method and mass spectrometer apparatus is introduced to enable collision induced dissociation inside linear ion traps/guides or 3d ion traps based on digital waveform manipulation. In particular, using the device's digitally produced trapping waveforms to trap, isolate and energize the ions of interest creates a simplified and versatile ion trap/guide that is capable tandem mass spectrometry and high sensitivity.
Washington State University


 Synchronised variation of source conditions of an atmospheric pressure chemical ionisation mass spectrometer coupled to a gas chromatograph to improve stability during analysis patent thumbnailSynchronised variation of source conditions of an atmospheric pressure chemical ionisation mass spectrometer coupled to a gas chromatograph to improve stability during analysis
A mass spectrometer is disclosed comprising a gas chromatography separation device, an atmospheric pressure ionisation ion source and a control system arranged and adapted: (i) to operate the atmospheric pressure ionisation ion source at one or more first settings for a first period of time whilst one or more solvents elute from the gas chromatography separation device during a solvent front; and then (ii) to operate the atmospheric pressure ionisation ion source at one or more second different settings for a second subsequent period of time whilst one or more analytes elute from the gas chromatography separation device.. .
Micromass Uk Limited


 Inert atmospheric solids analysis probe system patent thumbnailInert atmospheric solids analysis probe system
Systems and methods for ionization of a sample and mass separation of the ions by a mass spectrometer are disclosed herein.. .
Advion Inc.


 Solid phase extraction with capillary electrophoresis patent thumbnailSolid phase extraction with capillary electrophoresis
Methods, systems and devices that provide fluid devices with at least one spe bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a mass spectrometer. The fluid device can be configured to operate using independently applied pressures to a bge reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used.
The University Of North Carolina At Chapel Hill


 Sample plate using maldi-tof mass spectrometer and manufacturing  the sample plate patent thumbnailSample plate using maldi-tof mass spectrometer and manufacturing the sample plate
A sample plate in use with a maldi-tof (matrix-assisted laser desorption ionization time-of-flight) mass spectrometer. The sample plate is usable for the mass spectrometry of a polymeric material on the order of several hundreds of da and a method of manufacturing the same sample plate.
University-industry Foundation(uif), Yonsei University


 Device for mass spectrometry patent thumbnailDevice for mass spectrometry
A device for mass spectrometry comprises an ionization source, a mass analyzer fluidly coupled to the ionization source and an electronic data acquisition system for processing signals provided by the mass analyzer. The electronic data acquisition system comprises at least one analog-to-digital converter (10) producing digitized data from the signals obtained from the mass analyzer and a fast processing unit (47) receiving the digitized data from said analog-to-digital converter (10).
Tofwerk Ag


 Structural elucidation of intact heavy molecules and molecular complexes in mass spectrometers patent thumbnailStructural elucidation of intact heavy molecules and molecular complexes in mass spectrometers
The invention relates to mass spectrometric analyses of heavy molecules and molecular complexes having molecular weights sometimes well above 100,000 daltons, by collision treatment in linear rf multipole collision cells. A mixture of at least one light collision gas (<40 daltons) and at least one heavy collision gas (>80 daltons) is provided in a linear rf collision cell.
Bruker Daltonik Gmbh


 Mass spectrometry  organic acid, analytical column and analytical device patent thumbnailMass spectrometry organic acid, analytical column and analytical device
A mass spectrometry method by a liquid chromatograph-mass spectrometer that can detect an organic acid with high sensitivity by retaining, separating and eluting the organic acid without adding any nonvolatile substance to a mobile phase and without receiving any restriction of a ratio of a water-soluble organic solvent, and an analytical column are provided. The mass spectrometry method is a mass spectrometry method for an organic acid by a liquid chromatograph-mass spectrometer, wherein a column packed with a hydrophilic polymer having an anion-exchange group is used, and as a mobile phase, a water-soluble organic solvent-water mixed solution is used.
Showa Denko K.k.


 Method for monitoring gas lift wells using minimal concentration tracer materials patent thumbnailMethod for monitoring gas lift wells using minimal concentration tracer materials
A method for evaluating annulus-tubing communication points in a production well having an annulus between a production string and a surrounding string(s) of casing. Determining a composition of production fluids produced from the well, and injecting one or more tracer materials into the annulus of the well under pressure as part of a lift gas.

 Systems for separating ions and neutrals and methods of operating the same patent thumbnailSystems for separating ions and neutrals and methods of operating the same
A mass spectrometer system includes a sample injection device defining a sample injection aperture. The system also includes an ion trap defining an ion outlet aperture.
Morpho Detection, Llc


Electrospray ionization interface to high pressure mass spectrometry and related methods

An electrospray ionization (esi)-mass spectrometer analysis systems include an esi device with at least one emitter configured to electrospray ions and a mass spectrometer in fluid communication with the at least one emitter of the esi device. The mass spectrometer includes a mass analyzer held in a vacuum chamber.
The University Of North Carolina At Chapel Hill

High pressure mass spectrometry systems and methods

Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.

Time of flight mass spectrometer

A time of flight (“tof”) mass spectrometer including: an ion source configured to produce ions having a plurality of m/z values; a detector for detecting ions produced by the ion source; a tilt correction device located along a portion of a reference ion flight path extending from the ion source to a planar surface of the detector; wherein the tilt correction device includes tilt correction electrodes configured to generate at least one dipole electric field across the reference ion flight path, the at least one dipole electric field being configured to tilt an isochronous plane of ions produced by the ion source so as to correct a previous angular misalignment between the isochronous plane and the planar surface of the detector.. .
Shimadzu Corporation

Sample transferring mass cytometry

In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (icp) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion.
Fluidigm Canada Inc.

Chromatograph mass spectrometer and control method therefor

A technician is forced to determine the measurement time to be used in a selected ion monitoring (sim) measurement while observing mass spectral data. Thus, mass spectral data and one or a plurality of mass chromatogram data items is generated on the basis of the detection results of an ion detection unit, and, for each corresponding ion component, the measurement time to be used in sim is determined on the basis of the elution time range represented by each peak waveform of the one or plurality of mass chromatogram data items that have been generated..
Hitachi High-technologies Corporation

Method for converting mass spectral libraries into accurate mass spectral libraries

At least one product ion mass spectrum produced by a tandem mass spectrometer is received. A chemical structure of a compound that corresponds to the at least one product ion mass spectrum is received.
Dh Technologies Development Pte. Ltd.

Methods of analyte derivatization and enhanced soft ionization

Methods of analyte derivatization and soft ionization are provided. The methods include contacting a sample including an analyte with a derivatization agent to produce a modified analyte including a pseudo-molecular analyte group and a leaving group connected via a fragmentable bond; and selectively breaking the fragmentable bond under soft ionization conditions to produce a predominant first fragmentation product including the pseudo-molecular analyte group and a second fragmentation product including the leaving group.
Agilent Technologies, Inc.

Mass spectrometer

A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells.
Micromass Uk Limited

Mass spectrometer

An elemental mass spectrometer uses a mass filter to select ions from ions received from an ion source and transmit the selected ions. A reaction or collision cell receives the transmitted ions and reacts or collides these with a gas to provide product ions thereby.
Thermo Fisher Scientific (bremen) Gmbh

System and methodology for expressing ion path in a time-of-flight mass spectrometer

A system for expressing an ion path in a time-of-flight (tof) mass spectrometer. The present invention uses two successive curved sectors, with the second one reversed, to form s-shaped configuration such that an output ion beam is parallel to an input ion beam, such that the ions makes two identical but opposed turns, and such that the geometry of the entire system folds into a very compact volume.
Noaa Technology Partnerships Office

Maldi-tof mass spectrometers with delay time variations and related methods

Maldi-tof ms systems have solid state lasers and successive and varied delay times between ionization and acceleration (e.g. Extraction) to change focus masses during a single sample signal acquisition without requiring tuning of the ms by a user.
Biomérieux, Inc.

Systems and methods for rapidly screening samples by mass spectrometry

Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor.
Dh Technologies Development Pte. Ltd.

Method of analysis of component in sample, specific isolation of component in sample, and sample for mass spectrometry

Trace components in a sample can be analyzed quickly and accurately using a small sample quantity and without preprocessing such as concentration, by a method for analyzing a component in a sample, the method including a step for irradiating a thermoplastic resin film internally containing the sample with ionizing laser light of a mass spectrometer.. .

Blanking out of pulses in pulsed lasers for ldi mass spectrometers

The invention relates to optically pumped and pulsed solid-state lasers which are used in mass spectrometers in particular for ionization by matrix-assisted laser desorption (maldi) and which operate at pulse frequencies of up to 10 kilohertz or even higher. The invention proposes that, instead of interrupting the clocked sequence of the laser operation, individual light pulses or groups of light pulses are blanked out so that subsequent light pulses do not have a higher energy density, in accordance with the requirements for ldi processes.
Bruker Daltonik Gmbh

Mass spectrometer

A mass spectrometer includes a beam radiator radiating a beam to a sample. A laser radiator radiates laser light onto an irradiation surface of a surface of the sample irradiated with the beam or above the irradiation surface.
Kabushiki Kaisha Toshiba

Methods and systems for cell state quantification

Systems, methods, libraries, kits, and computer software tools are provided for designing and producing engineered cells. Such engineered cells can be used for cell state quantification, such as genome, transcriptome and/or proteome quantification.
Ginkgo Bioworks, Inc.

Methods for operating a system comprising a coupled mass spectrometer and ion mobility spectrometer

A method of operating a system comprising a chromatograph, an ion source, a mass spectrometer having a mass analyzer and an ion mobility spectrometer interposed between the ion source and the mass analyzer, comprising: performing a first chromatographic and mass analysis of a sample while operating the ion mobility spectrometer in non-dispersive mode, wherein a respective ion-signal-acquisition time (at) and a corresponding loss-of-ion-signal time (lt) are identified for each detected m/z ratio that corresponds to a precursor-ion m/z ratio of interest; and performing a second chromatographic and mass analysis of the sample during which, for each identified at and lt, the corresponding respective precursor ion is fragmented to generate product ions and the product ions are detected by the mass analyzer, wherein the ion mobility spectrometer is operated in dispersive mode such that ions of said each respective precursor-ion species are preferentially transmitted therethrough spectrometer to the mass analyzer.. .
Thermo Finnigan Llc

Vacuum pump and mass spectrometer

One or more through-holes communicating with one or more of the plurality of screw grooves are formed at the cylindrical stator, a total of circumferential dimensions of the one or more through-holes formed at the cylindrical stator is set at equal to or greater than a circumferential dimension of an outer peripheral surface region of the cylindrical stator facing the second suction port, and a gas path through which inflow gas through the second suction port is guided to a screw groove is provided, the one or more through-holes penetrating through the screw groove and the screw groove being apart from the region facing the second suction port.. .
Shimadzu Corporation

System and an integrated satellite platform

A system, method, and computer-readable storage devices for a 6u cubesat with a magnetometer boom. The example 6u cubesat can include an on-board computing device connected to an electrical power system, wherein the electrical power system receives power from at least one of a battery and at least one solar panel, a first fluxgate sensor attached to an extendable boom, a release mechanism for extending the extendable boom, at least one second fluxgate sensor fixed within the satellite, an ion neutral mass spectrometer, and a relativistic electron/proton telescope.
U.s.a. As Represented By The Administrator Of The National Aeronautics And Space Administration

Glow discharge ion source

A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber.
Micromass Uk Limited

Ion guide with orthogonal sampling

A mass spectrometer is disclosed comprising a rf ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the rf ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar..
Micromass Uk Limited

Data processing system and program for chromatograph mass spectrometer

In a chromatogram mass spectrometer's data processing system, if the intensity of a target peak originating from a target component at a target mass-to-charge ratio is equal to or higher than a threshold, the mass-to-charge ratio of a peak having a signal intensity lower than the threshold on the mass spectrum corresponding to the point in time where the target peak appears is designated as a correction mass-to-charge ratio. A mass spectrum at a point in time in the target peak where the signal intensity does not exceed the threshold is acquired.
Shimadzu Corporation

Mass spectrometry method and mass spectrometer

In a mass spectrometry method for performing a qualitative and/or quantitative determination of an analyte compound contained in a sample, using a mass chromatogram acquired for one or a plurality of ions selected as a reference ion from the ions produced from the analyte compound, the present method includes the steps of: setting one or a plurality of reference-ion candidates for each of the one or a plurality of reference ions; acquiring a mass chromatogram of the sample for each of the set reference-ion candidates; calculating a shape similarity between a peak appearing at a predetermined position on the mass chromatogram and a preset model peak; and designating, as the reference ion, a reference-ion candidate corresponding to a peak having the shape similarity equal to or higher than a predetermined value.. .
Shimadzu Corporation

Mass spectrometer with digital step attenuator

A method is disclosed comprising passing a signal output from a detector through a programmable attenuator or a programmable amplifier prior to digitising the signal, and switching an attenuation factor or gain factor of the programmable attenuator or the programmable amplifier one or more times during a data acquisition period.. .
Micromass Uk Limited

Paper cone tip, and paper cone spray ionization mass spectrometry using the same

A paper cone tip, having a triangular-pyramidal shape with a vertex angle of 12.5° to 45°, and to a paper cone spray ionization mass spectrometry (pcsi ms) method using a paper cone tip, including: preparing the paper cone tip having a triangular-pyramidal shape; placing a measuring sample in the paper cone tip and locating the paper cone tip in front of a mass spectrometer; and adding a spraying solvent to the paper cone tip and applying a voltage thereto. The paper cone tip having a triangular-pyramidal shape is suitable for use in pcsi ms for the direct analysis of solid samples of raw materials, and the three-dimensional paper cone tip serves as a sample container, a solid-liquid extraction chamber, an analyte transport channel, and an electrospray tip..
Hankuk University Of Foreign Studies Research & Business Foundation

Mass spectrometer data acquisition

A data acquisition system for a tof mass spectrometer comprises a processing module and a data collection module. The processing module generates a stream of data comprising, for each respective transient of a first scan, a set of time-intensity related parameter pairs.
Micromass Uk Limited

Mass spectrometer with reduced potential drop

A method of mass spectrometry is disclosed comprising providing a first device and a second device disposed downstream of the first device. The method further comprises introducing a potential difference between the exit of the first device and the entrance of the second device and reducing the total potential drop across the first and second devices by applying a reverse axial electric field to the first device and/or the second device.
Micromass Uk Limited

Microbial identification and quantitation using ms cleavable tags

Systems and methods are provided for microbial identification using cleavable tags. Control information is sent to a mass spectrometer to select a peptide labeled with a first tag of a known microbe, fragment the labeled peptide of the known microbe, and monitor for an intensity of the first tag in an mrm method using a processor.
Dh Technologies Development Pte. Ltd.

Dynamic range improvement for isotope ratio mass spectrometry

In a mass spectrometer, a mass-to-charge dispersive element separates received ions spatially according to their mass-to-charge ratios, to provide a dispersed ion beam thereby. An ion detection arrangement that detects the dispersed ion beam comprises: at least one primary ion detector, each detecting spatially separated ions having mass-to-charge ratios within a respective desired range and each providing a respective main beam signal based on its respective detected ions; and at least one secondary ion detector, each detecting ions having mass-to-charge ratios outside all of the desired ranges simultaneously with the at least one primary ion detector detecting the spatially separated ions and each providing a respective background signal based on its respective detected ions.
Thermo Fisher Scientific (bremen) Gmbh

Mirror lens for directing an ion beam

An electrostatic dual-mode lens assembly is provided for selectively transmitting or reflecting an ion beam in a mass spectrometer. The assembly comprises at least one electrode that provides a switchable electric field that, during a first mode of operation, directs an ion beam that enters the assembly along a first path so that the beam is transmitted through the assembly along the first path, and during a second mode of operation, directs an ion beam that enters the assembly along the first path so that the ion beam is reflected by the electric field and exits the assembly along a second path.
Thermo Fisher Scientific (bremen) Gmbh

Detector and slit configuration in an isotope ratio mass spectrometer

A method of configuring a faraday detector in a mass spectrometer is described. The mass spectrometer defines a central ion beam axis i, and the faraday detector is moveable relative to the central ion beam axis i.
Thermo Fisher Scientific (bremen) Gmbh

Mass spectrometer with interleaved acquistion

A method of mass spectrometry is disclosed comprising passing ions through a first stage and a second stage of a mass spectrometer and monitoring a first ion acquisition for a first dwell time extending from a time t1 to a time t1+tdwell1. The method further comprises reconfiguring the mass spectrometer or one or more components of the mass spectrometer to monitor a second ion acquisition and setting the first stage to transmit ions of the second ion acquisition at a time t, wherein t<t1+tdwell1.
Micromass Limited Uk

Quantitative measurements of elemental and molecular species using high mass resolution mass spectrometry

A method for generating a mass spectrum of sample ions using a multi-collector mass spectrometer is disclosed. The mass spectrometer includes a spatially dispersive mass analyser to direct the sample ions into a detector chamber.
Thermo Fisher Scientific (bremen) Gmbh

Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences

A method of checking or adjusting the calibration of a mass spectrometer is disclosed. The method comprises fragmenting parent or precursor ions and generating fragment or product ion mass spectral data and recognising first neutral loss ions in the fragment or product ion mass spectral data.
Micromass Uk Limited

Multi-trace quantitation

Systems and methods are provided for calculating the area of a peak profile using information from one or more correlated peak profiles. One or more compounds are separated from a mixture over time using a separation device.
Dh Technologies Development Pte. Ltd.

High pressure mass resolving ion guide with axial field

A mass spectrometer is disclosed comprising a first mass filter comprising a plurality of electrodes and a first device arranged and adapted to generate an axial force which drives at least some ions axially through or along the first mass filter and a quadrupole mass filter or mass analyser arranged downstream of the mass filter.. .
Micromass Uk Limited

Mass spectrometer

Methods and apparatus for operating a mass spectrometer are described. In various aspects, ions of a mass range of interest may be mass-selectively ejected from an accumulation ion trap into a multi-ion trap structure.
Dh Technologies Development Pte Ltd.

Multi-reflecting time-of-flight mass spectrometer with axial pulsed converter

Apparatuses (41, 91, 111, 115, 121, 151) and methods (31) for time-of-flight mass spectrometry providing effective pulsed conversion of continuous ion beams into pulsed ion packets is disclosed. Bunching of energetic continuous ion beams forms ion packets, which are filtered by a subsequent isochronous energy filter (49, 79, 81-84, 110).
Leco Corporation

Ion source for mass spectrometry

Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling.
Dh Technologies Development Pte. Ltd.

Data independent acquisition of product ion spectra and reference spectra library matching

Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor.
Eth Zürich

Mass spectrometry method, mass spectrometry , and mass spectrometric data processing program

In a mass spectrometric method of the invention, a mass spectrometer (2) is used having a mass separation unit (231, 234) before and after a collision cell (232) for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum.
Shimadzu Corporation



Mass Spectrometer topics:
  • Mass Spectrometer
  • Spectrometer
  • Mass Spectrometry
  • Spectrometry
  • Downstream
  • Coordinates
  • Quantitative
  • Chromatograph
  • Data Processing
  • Biomolecule
  • Data Acquisition
  • Electrical Signal
  • Data Compression
  • Fragmentation
  • Irradiation


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    This listing is a sample listing of patent applications related to Mass Spectrometer for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mass Spectrometer with additional patents listed. Browse our RSS directory or Search for other possible listings.


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