|| List of recent Mass Spectrometer-related patents
|Mass spectrometer and method of driving ion guide|
A method of operating an electrode changeover switch which switches the connection state of electrodes, the electrode changeover switch is provided in the wiring path between eight electrodes through, arranged rotation-symmetrically about ion optical axis, and voltage generation switch which generates square wave high voltage ±v. When switch is switched as shown in the drawing, two circumferentially adjacent rod electrodes are connected to form one set, a square wave voltage of opposite phase is applied to circumferentially adjacent sets, and an effectively quadrupole electric field is formed.
|Imaging mass spectrometer and a method of mass spectrometry|
An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process.. .
|Methods for predictive automatic gain control for hybrid mass spectrometers|
A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer.. .
|Windowing combined with ion-ion reactions for chemical noise elimination|
In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location.
|Gas diffuser ion inlet|
In some embodiments, a gas diffuser for use in a mass spectrometer is disclosed that can provide a controlled expansion of an ion-containing gas so as to reduce gas velocity for entry into subsequent stages of the mass spectrometer, e.g., a mass analyzer. In some embodiments, the controlled expansion of the gas is provided by flowing the gas through a channel whose cross-sectional area change, e.g.
|Creating an ion-ion reaction region within a low-pressure linear ion trap|
Methods and systems for creating a region for ion-ion reactions within a mass spectrometer are described. In various aspects, the methods and systems can confine a first group of ions in a sub-volume of a multipole ion trap, and introduce a second group of oppositely-charged ions into the multipole ion trap while maintaining the first group of ions within the sub-volume.
|Strategic dynamic range control for time-of-flight mass spectrometry|
A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters.
A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis.
|Mass spectrometer with beam expander|
A mass spectrometer is disclosed comprising a rf confinement device, a beam expander and a time of flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the rf confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the time of flight mass analyser..
|Method and a mass spectrometer and uses thereof for detecting ions or subsequently-ionised neutral particles from samples|
A method is used in a time-of-flight mass spectrometer for analysis of a first pulsed ion beam, the ions of which are disposed along the pulse direction, separated with respect to their ion masses. The ions of at least one individual predetermined ion mass or of at least one predetermined range of ion masses can be decoupled from the first pulsed ion beam, as at least one decoupled ion beam, and the first ion beam and the at least one decoupled ion beam are analyzed..
|High-energy ion implanter|
A high-energy ion implanter includes: a beam generation unit that includes an ion source and a mass spectrometer; a radio frequency multi-stage linear acceleration unit; a deflection unit that includes a magnetic field type energy analysis device for filtering ions by a momentum; a beam transportation line unit; and a substrate processing/supplying unit. In this apparatus, an electric field type final energy filter that deflects a high-energy scan beam in the vertical direction by an electric field is inserted between the electric field type beam collimator and the wafer in addition to the magnetic field type mass spectrometer and the magnetic field type energy analysis device as momentum filters and the radio frequency multi-stage linear acceleration unit as a velocity filter..
A mass spectrometer including chromatogram creation means for creating a chromatogram showing changes over time in an ion intensity within a predetermined mass range based on the ms analysis results, and timing determination means for determining a timing to perform ms/ms analysis based on the chromatogram. The timing determination means determines, as a timing to perform ms/ms analysis, a point in time at which a signal intensity in the chromatogram reaches a predetermined upper limit after exceeding a predetermined lower limit or a point in time at which a signal intensity in the chromatogram reaches a top of a peak without reaching the upper limit after exceeding the lower limit.
|High resolution time-of-flight mass spectrometer|
Mass spectrometers and related methods of making and using the same are disclosed herein that generally involve positioning a blocking or masking element in the path of an ion beam passing through the mass spectrometer so as to selectively block at least a portion of the ions in the ion beam from entering an accelerator. Mass spectrometers and related methods are also disclosed in which an ion beam passing through the mass spectrometer is deflected or otherwise aimed so as to approach a tof axis of an accelerator at a non-zero angle..
|Mass spectrometer vacuum interface method and apparatus|
A method of operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and downstream ion extraction optics. An expanding plasma is skimmed through the skimmer aperture.
|Systems, devices, and methods for sample analysis using mass spectrometry|
A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer.
|Identification of related peptides for mass spectrometry processing|
A method of identifying a related peak set from ms1 spectra data is provided. An intensity peak is selected from ms1 spectra data generated for a sample by a tandem mass spectrometer.
|Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers|
An ion source able to ionize liquid and gaseous effluents from interfaced liquid or gaseous separation techniques and from direct introduction of the analyte to the entrance of the ionization region. The liquid effluents from sources such as a liquid chromatograph are ionized by inlet ionization methods and the gaseous effluents from sources such as a gas chromatograph are ionized by a corona or townsend electrical discharge, or an alpha or beta emitter, or by inlet ionization, or by photoionization.
|Mass spectrometer arranged to perform ms/ms/ms|
A mass spectrometer is disclosed comprising an on trap and a fragmentation device. Ions are fragmented in the on trap to form first generation fragment ions.
|Use of windowed mass spectrometry data for retention time determination or confirmation|
A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans.
|Apparatus and method relating to an improved mass spectrometer|
The present disclosure provides a mass spectrometer including means for producing a primary beam of ions for bombarding a sample under vacuum and a detector for detecting a secondary beam of ions released from the sample. The primary beam of ions includes a gaseous mixture of a cluster forming gas and one or more hydrogen-rich hydrocarbons..
|Mass spectrometer vacuum interface method and apparatus|
A method of preparing or operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and an internal surface of the skimmer apparatus, comprising disposing an adsorbent or getter material on the internal surface. The internal surface has a deposition region where matter from plasma flows may be deposited and the material is disposed on part or all of the deposition region.
After a first injection of a sample, amount of change between a highest intensity and each of two ion intensities before and after a voltage showing the highest intensity is calculated for each ce voltage. If the change is equal to or less than a threshold the ce voltage showing the highest intensity in the coarse control mode is selected as the optimal value, without performing a measurement in a fine control mode.
|Atmospheric pressure ion source for mass spectrometry|
A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as atmospheric pressure chemical ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions.
A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised.
|Methods, apparatus, and system for mass spectrometry|
A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments.
|Diathermy knife ionisation source|
A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife.
A mass spectrometer is disclosed comprising an electron transfer dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell.
There is provided an ion reflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The reflector includes an electric field capable of causing a flow of ions focused through a first spatial region to be focused toward a second spatial region, whereby the first and second spatial regions are aligned with respective axes of travel..
|System and method for applying curtain gas flow in a mass spectrometer|
A system of mass spectrometry is disclosed having an ion source for generating ions at substantially atmospheric pressure. The system has a sampling member with an orifice disposed therein.
|Intelligent background data acquisition and subtraction|
A scan of a separating sample mixture is received from a mass spectrometer at each interval of a plurality of intervals. It is determined at a first interval that a received mass spectrometry scan at the first interval and one or more preceding received mass spectrometry scans include a varying ion signal that represents an ion of a known compound and has an intensity above a threshold level.
|Low cross-talk fast sample delivery system based upon acoustic droplet ejection|
An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.. .
|Apparatus and method relating to an improved mass spectrometer|
A mass spectrometer comprising means for producing a primary beam of ions for bombarding a sample under vacuum, and a detector for detecting a secondary beam of ions released from the sample. The primary beam of ions includes water clusters where each water cluster contains between 1 and 10,000 water molecules..
|Imaging mass analysis data processing method and imaging mass spectrometer|
If spatial measurement point intervals in imaging mass analysis data of two samples to be compared are different and the degrees of spatial distribution spreading of substances are compared, one of the data is defined as a reference, the measurement point intervals in the other of the data are redefined so as to be equalized to the reference, and a mass spectrum at each virtual measurement point set as a result of the redefinition is obtained through interpolation or extrapolation based on a mass spectrum at an actual measurement points. If the arrays of the m/z values of mass spectra are different for each sample, the m/z value positions of the mass spectrum in one of the data are defined as a reference, and the intensity values corresponding to the reference m/z values are obtained through interpolation or extrapolation for the mass spectrum of the other of the data..
|Capturing of cell fluid and analysis of its components under observation of cells and instruments for the cell fluid capturing and the analysis|
A method captures cellular components from a single cell and performs mass spectrometry on the components. The method includes inserting a nanospray ionization capillary tip into a specific region of the cell under observation with a microscope.
|Chemical ionization with reactant ion formation at atmospheric pressure in a mass spectrometer|
The invention relates to the production of water cluster ions (“hydronium clusters”) at atmospheric pressure for the chemical ionization of analyte molecules. It is proposed that a corona discharge at the taylor cone of an aqueous liquid, preferably pure or slightly acidified pure water, is used instead of corona discharges on metal tips, which have been the usual method up to now.
|Gaseous sample injection valve and gaseous sample injection method using same|
The present invention relates to a gaseous sample injection valve. The gaseous sample injection valve includes a middle body injecting a fixed amount of a gaseous sample into the vacuum chamber of a mass spectrometer, the middle body being constituted by a gaseous sample injection tube, a gaseous sample discharge tube, a storage part, and a vacuum chamber connection tube; an upper body accommodating a first solenoid coil, a first plunger, and a first packing; and a lower body accommodating a second solenoid coil, a second plunger, and a second packing.
|Simultaneous inorganic mass spectrometer and method of inorganic mass spectrometry|
An inorganic mass spectrometer capable of measuring a relevant and large or the full mass spectral range simultaneously may include a suitable ion source (e.g., an icp mass spectrometer with an icp ion source), an ion transfer region, ion optics to separate ions out of a plasma beam, a mattauch-herzog type mass spectrometer with a set of charged particle beam optics to condition the ion beam before an entrance slit, and a solid state multi-channel detector substantially separated from ground potential and separated from the potential of the magnet.. .
|Signal processing for mass directed fraction collection|
A system and removing noise from a mass spectrometer signal for fraction collection is described herein.. .
|Methods for predictive automatic gain control for hybrid mass spectrometers|
A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising performing a survey mass analysis using a mass analyzer to measure a flux of ions having m/z ratios within said restricted range and performing a dependent mass analysis of an optimal quantity of ions having m/z ratios within said restricted range, said optimal quantity collected for a time period determined by the measured ion flux, characterized in that: the time period is determined using a corrected ion flux that accounts for one or more of: (a) imperfect restriction of collected ions to the range of m/z ratios, (b) inclusion of ions within the range of m/z ratios that are undetected by the survey mass analysis, (c) different mass analyzers used for the dependent and survey mass analyses, and (d) different ion pathways used during dependent and the survey mass analyses.. .
|Method for automated checking and adjustment of mass spectrometer calibration|
A method for automatically checking and adjusting a calibration of a mass spectrometer having a first quadrupole (q1), a fragmentation cell and a mass analyzer comprises: introducing a sample having at least one known chemical entity; decreasing a kinetic energy so as to prevent fragmentation of ions in the fragmentation cell; optionally applying a drag field to the fragmentation cell; ionizing the at least one known chemical entity sample to generate a set of ions; performing a mass scan of the set of ions using q1; transmitting the scanned ions through q1 to and through the fragmentation cell; detecting the scanned and transmitted ions by a detector of the mass analyzer; and comparing the results with expected results. Embodiments may include automatic recalibration or notification of possible errors, need for further data processing or an analysis of system performance..
|High-throughput mass-spectrometric characterization of samples|
The invention relates to the characterization of samples which are located in their many hundreds up to tens or hundreds of thousands on a sample support plate in a regular pattern, a so-called array, by ionization with matrix-assisted laser desorption and mass spectrometric measurement, for example. The invention proposes that the position of the sample pattern, and thus the position of each sample in the measuring instrument, for example a mass spectrometer, should be determined by measuring at least two finely structured internal position recognition patterns, such as fine crosses.
|Ion inlet for a mass spectrometer|
An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing.
|Method and device for determining properties of gas phase bases or acids|
Properties, such as concentrations, of gas phase bases or acids of a gas sample are determined by providing a sample gas flow, which includes the bases or acids to be determined as sample constituents, as well as also interfering constituents, which are other constituents than the sample constituents. Reagent ions are provided and introduced into the sample gas flow to arrange proton transfer reaction and thereby forming sample ions.
|Apparatus for improved immunosuppressant drug monitoring|
A liquid chromatography/mass spectrometry system includes: a source of a first mobile phase solvent consisting essentially of water plus 10 mm ammonium formate plus 0.05% formic acid; a source of a second mobile phase solvent consisting essentially of methanol plus 10 mm ammonium formate plus 0.05% formic acid; a chromatography column comprising a length of 30 mm or less of a stationary phase comprising an 8-carbon alkyl chain material bonded to 2.6 μm diameter particles having solid silica cores surrounded by porous silica outer layers; an electrospray ion source of a mass spectrometer fluidically coupled to the chromatography column so as to generate ions therefrom; a mass analyzer of the mass spectrometer operable to quantitatively detect the ions; and a programmable processor electronically coupled to the mass analyzer and comprising instructions operable to determine, based on the ion detection, a concentration of everolimus, sirolimus, tacrolimus, or cyclosporin a.. .
|Apparatus for elemental analysis of particles by mass spectrometry|
A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
|Quantitative analysis method using mass spectrometer|
In an ms unit, both an intensity of an ion having the highest intensity among the ions originating from a compound as the target of quantitative determination and an intensity of an isotopic ion are measured. A saturation detector determines whether or not digital data produced by an a/d converter from ion-intensity signals have reached a saturation level.
|Mass dependent automatic gain control for mass spectrometer|
Systems and methods for automatic gain control in mass spectrometers are disclosed. An exemplary system may include a mass spectrometer, comprising a lens configured to receive a supply of ions, and a mass analyzer.
|Combined ion source for electrospray and atmospheric pressure chemical ionization|
An ion source for a mass spectrometer comprises: a capillary having a nozzle for emitting a nebulized fluid sample; an electrode of the capillary; a high voltage power supply electrically coupled to the electrode; a second electrode disposed within or configurable to be disposed within a path of the nebulized fluid sample, wherein the capillary and capillary electrode are configurable so as to ionize the nebulized fluid sample by electrospray ionization and the second electrode is configurable so as to ionize the nebulized sample by atmospheric pressure chemical ionization and wherein the second electrode is moveable between positions such that the second electrode is and is not disposed within the path of the nebulized fluid sample, respectively.. .
|Multi inlet for solvent assisted inlet ionisation|
A mass spectrometer is disclosed comprising a dual channel solvent assisted inlet ionisation (“saii”) interface.. .
|Quantification of an analyte in serum and other biological matrices|
Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow.. .
|Mass analyser, mass spectrometer and associated methods|
A mass analyser for use in a mass spectrometer. The mass analyser has a set of electrodes including electrodes arranged to form at least one electrostatic sector, the set of electrodes being spatially arranged to be capable of providing an electrostatic field in a reference plane suitable for guiding ions along a closed orbit in the reference plane, wherein the set of electrodes extend along a drift path that is locally orthogonal to the reference plane and that curves around a reference axis so that, in use, the set of electrodes provide a 3d electrostatic field region.
|Photo-dissociation of proteins and peptides in a mass spectrometer|
A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2d or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected.
|Atmospheric pressure ionization mass spectrometer|
In an atmospheric pressure ionization source using an esi or the like having a desolvation pipe with one end opening serving as an ion-drawing port, a drying-gas supplying port for supplying a drying gas against the ion-drawing direction is provided below the ion-drawing port, i.e. At a position opposite to the side where a nozzle for spraying a liquid sample into an atmospheric pressure atmosphere is located, as viewed from the ion-drawing port.
|Ion mobility spectrometer|
A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the ims.
|Mass spectrometers comprising accelerator devices|
A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device.
|Lens for electron capture dissociation, fourier transform ion cyclotron resonance mass spectrometer comprising the same and method for improving signal of fourier transform ion cyclotron resonance mass spectrometer|
A lens for electron capture dissociation may include: a first electrode and a second electrode spaced apart from each other and arranged along a first direction; and a third electrode and a fourth electrode spaced apart from each other and arranged along a second direction perpendicular to the first direction. The first electrode and the second electrode may be disposed in a space in which a magnetic field is formed in the first direction and trap electrons.
|Multi-nozzle chip for electrospray ionization in mass spectrometers|
The invention involves electrospray ionization of dissolved substances at atmospheric pressure in the ion source of a mass spectrometer. A chip with a multitude of spray nozzles is proposed, where each individual spray nozzle is surrounded by several sheath gas nozzles, preferably in a symmetric arrangement, for the jet-like introduction of a sheath gas.
|Tubular membrane gas and volatile compounds sampler for fluid introduction at atmospheric to high pressure|
A high-transmittance sampler of dissolved gases and volatile organic compounds (voc) is described that is based upon a thin polymer membrane with tubular geometry. Very high hydrostatic pressures are maintained by surrounding the polymer tube or coating with sintered material.
|Method and apparatus for monitoring ion lens connections|
This technology is directed to a method and apparatus for monitoring or testing defects associated with an ion lens connected within a mass spectrometer. In some implementations, the testing mechanism monitors a connection of one or more ion lenses configured in the mass spectrometer to determine if voltage is effectively applied to the ion lens.
|Mass spectrometer having an external detector|
A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space.
|Orthogonal acceleration system for time-of-flight mass spectrometer|
An orthogonal pulse accelerator for a time-of-flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension.
|Ionization within ion trap using photoionization and electron ionization|
A mass spectrometer is disclosed. The mass spectrometer may include an ion trap configured to trap and analyze an ionized sample.
|Differential mobility spectrometer and methods thereof|
An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions.
A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser.
|Identifying the occurrence and location of charging in the ion path of a mass spectrometer|
A method is described for identifying the occurrence and location of charging of ion optic devices arranged along the ion path of a mass spectrometer. The method includes repeatedly performing a sequence of introducing a beam of discharge ions to a location on the ion path, and subsequently measuring the intensities of opposite-polarity sample ions delivered to a mass analyzer, with the discharge ions being delivered to a location further downstream in the ion path at each successive sequence..
|Method for cleaning an atmospheric pressure chemical ionization source|
Build-up of surface contamination within an atmospheric pressure chemical ionization (apci) source of a mass spectrometer (ms) is reversed by switching the apci polarity to the opposite setting used for analyte ionization after the analytes have been ionized and measured. A solvent or mixture of solvents is passed through the ion source during the opposite-polarity operation.