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Mass Spectrometer patents



      

This page is updated frequently with new Mass Spectrometer-related patent applications.




Date/App# patent app List of recent Mass Spectrometer-related patents
02/04/16
20160035558 
 Multi-reflecting mass spectrometer patent thumbnailMulti-reflecting mass spectrometer
To improve spatial and energy acceptance of multi-reflecting time-of-flight, open traps, and electrostatic trap analyzers, a novel ion mirror is disclosed. Incorporation of immersion lens between ion mirrors allows reaching the fifth order time per energy focusing simultaneously with the third order time per spatial focusing including energy-spatial cross terms.
Leco Corporation


02/04/16
20160035557 
 Multi inlet for solvent assisted inlet ionisation patent thumbnailMulti inlet for solvent assisted inlet ionisation
A mass spectrometer is disclosed comprising a dual channel solvent assisted inlet ionisation (“saii”) interface.. .
Micromass Uk Limited


02/04/16
20160035554 
 Aperture gas flow restriction patent thumbnailAperture gas flow restriction
A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture.
Micromass Uk Limited


02/04/16
20160035552 
 Method and system for tandem mass spectrometry patent thumbnailMethod and system for tandem mass spectrometry
A method of data independent ms-ms analysis is disclosed. The method comprises ramping or stepping in small steps of a wide (at least 10 amu) parent mass window in a first parent selecting mass spectrometer (ms1), arranging rapid ion transfer through a collisional cell, either by axial gas flow or by an axial dc field or by a travelling rf wave, frequently pulsing an orthogonal accelerator with a string of time-encoded pulses, analyzing fragment ions in a multi-reflecting time-flight mass spectrometer, acquiring data in a data logging format, and decoding signal strings corresponding to the entire scan of parent masses, such that fragment spectra are formed based on time correlation between fragment and parent masses.
Leco Corporation


02/04/16
20160035550 
 Plasma cleaning for mass spectrometers patent thumbnailPlasma cleaning for mass spectrometers
A mass spectrometry (ms) system may be cleaned by generating plasma and contacting an internal surface of the system to be cleaned with the plasma. The system may be switched between operating in an analytical mode and in a cleaning mode.
Agilent Technologies, Inc.


02/04/16
20160035549 
 Hybrid mass spectrometer and methods of operating a mass spectrometer patent thumbnailHybrid mass spectrometer and methods of operating a mass spectrometer
A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list.
Thermo Finnigan Llc


02/04/16
20160033456 
 Gaseous mercury detection systems, calibration systems, and related methods patent thumbnailGaseous mercury detection systems, calibration systems, and related methods
Embodiments disclosed herein are directed to gaseous mercury detection systems, calibration systems, and related methods. The gaseous mercury detection systems are configured to detect gas-phase mercury-compounds present in ambient air.
Utah State University


01/28/16
20160029472 
 Plasma generator using dielectric resonator patent thumbnailPlasma generator using dielectric resonator
A dielectric resonator is excited at its natural resonant frequency to produce highly uniform electric field for the generation of plasma. The plasma may be used optical or mass spectrometer..
Radom Corporation


01/28/16
20160027633 
 Collision cell multipole patent thumbnailCollision cell multipole
mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion.
Thermo Fisher Scientific (bremen) Gmbh


01/28/16
20160027629 
 Apparatus for elemental analysis of particles by mass spectrometry patent thumbnailApparatus for elemental analysis of particles by mass spectrometry
A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio.
Fluidigm Canada Inc.


01/28/16
20160025656 

Microwave plasma spectrometer using dielectric resonator


A dielectric resonator is excited at its natural resonant frequency to produce a highly uniform electric field for the generation of plasma. The plasma may be used as a desolvator, atomizer excitation source and ionization source in an optical spectrometer or a mass spectrometer..
Radom Corporation


01/21/16
20160020082 

Mass spectrometer system and method


An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage u, an amplitude v of a radio-frequency voltage, and a frequency f of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger.
Hitachi High-technologies Corporation


01/21/16
20160020081 

Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer


Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows msn experiments to be performed on very basic mass spectrometers, even those without secondary mass analyzers and/or collision cells.
Wisconsin Alumni Research Foundation


01/21/16
20160020080 

Sample plate for maldi-tof mass spectrometer and manufacturing the sample plate and mass spectrometry method using the sample plate


The present invention relates to a sample plate to be used for a maldi-tof (matrix assisted laser desorption ionization time of flight) mass spectrometer, and more particularly, to a sample plate for a maldi-tof mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a maldi-tof mass spectrometer so as to overcome the limits of the gas chromatography method of the related art.
Industry-academic Cooperation Foundation, Yonsei University


01/21/16
20160018410 

Deep maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof


A method of analyzing a biological sample, for example serum or other blood-based samples, using a maldi-tof mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a maldi-tof sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument.
Biodesix, Inc.


01/21/16
20160018361 

System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry


An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges.

01/14/16
20160013040 

Ion trap mass spectrometer


An ion trap mass spectrometer including an ion trap analyzer, an ion packet injector, and an ion detector is disclosed, along with a method of mass spectrometry. The ion packet injector injects packets of ions into a field of the ion trap analyzer.
Leco Corporation


01/14/16
20160013038 

Use of mass spectral difference networks for determining charge state, adduction, neutral loss and polymerization


A mass spectrometric analysis method comprises: (1) processing a mass spectrum to reduce the signals to monoisotopic values; (2) creating a list of differences between the monoisotopic values; (3) creating one or more lists of theoretical mass-to-charge differences among known adducts, charge states and polymerization states whose formation may be expected from various analyte molecules; (4) comparing the theoretical differences (line or edge in the network) to the list of differences from the mass spectrum and, where applicable, make and tabulate tentative species assignments; (5) assigning the mass spectral peaks to respective ion species in accordance with the redundancy of each assignment based on multiple independent calculated mass-to-charge differences pertaining to each peak; (6) choosing an ion species for further fragmentation or reaction in the mass spectrometer, based on the assigning; and (7) performing the fragmentation or reaction on the chosen ion species in the mass spectrometer.. .
Thermo Finnigan Llc


01/14/16
20160013036 

Improved lock component corrections


A method of mass spectrometry is disclosed comprising initially calibrating or recalibrating a mass spectrometer at a time t0 and at the same time measuring a time of flight or mass to charge ratio m0 of one or more lockmass ions. The mass spectrometer is then operated at a subsequent time t1 and the time of flight or mass to charge ratio m1 of the one or more lockmass ions is measured at subsequent time t1.
Micromass Uk Limited


01/07/16
20160005587 

Ion trap mass spectrometer


An electrostatic analyzer including at least one first set of electrodes, at least one second set of electrodes, and a field free space separating the two sets of electrodes is disclosed. The two sets of electrodes form two-dimensional electrostatic fields of ion mirrors and are arranged to provide isochronous ion oscillations in an x-y plane.
Leco Corporation


01/07/16
20160005586 

Differentially pumped dual linear quadrupole ion trap mass spectrometer


The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (lqit) mass spectrometers with differentially pumped vacuum chambers..
Purdue Research Foundation


01/07/16
20160005585 

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction, the x direction being orthogonal to y, characterized in that the mirrors are not a constant distance from each other in the x direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer.
Thermo Fisher Scientific (bremen) Gmbh


01/07/16
20160005584 

Ion trap mass spectrometer


An electrostatic mass spectrometer and a method of mass spectrometric analysis utilizing novel traps are disclosed. The mass spectrometer includes an ion source, an ion pulse injector, an ion detector, a set of analyzer electrodes connected to a set of power supplies, and a vacuum chamber enclosing the set of analyzer electrodes.
Leco Corporation


01/07/16
20160005583 

Reflectors for time-of-flight mass spectrometers


The invention relates to reflectors for time-of-flight mass spectrometers, and especially their design. A mamyrin reflector is provided which consists of metal plates with cut-out internal apertures, and symmetric shielding edges which are set back from the inner edges.
Bruker Daltonik Gmbh


01/07/16
20160005582 

Ion trap mass spectrometer


A mass spectrometer including an ion source, an ion guide, a pulsed converter, and an electrostatic analyzer is disclosed, along with a method of mass spectrometry and an ion injector. The ion source generates ions, such as ions within a continuous or a quasi-continuous ion beam.
Leco Corporation


01/07/16
20160005581 

Multiple ion gate method and apparatus


A second gate in an ion mobility spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the ion mobility mass spectrometer is used to modulate peak intensities in the ims spectrum, allowing each peak in the ims spectrum to be unambiguously matched with its set of fragment ions in a subsequent ms-ms mass spectrum..

01/07/16
20160005580 

Multi-reflection mass spectrometer


A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction and having a space therebetween, the x direction being orthogonal to y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the x direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length..
Thermo Fisher Scientific (bremen) Gmbh


01/07/16
20160005578 

Parallel elemental and molecular mass spectrometry analysis with laser ablation sampling


An apparatus for mass spectrometry includes a laser ablation sampler comprising a laser ablation chamber and a laser which produces a laser beam. The laser irradiates and ablates a material from a sample placed within the laser ablation chamber so as to generate an ablated sample material.
Westfaelische Wilhelms-universitaet Muenster


01/07/16
20160003787 

Method and system for monitoring biomolecule separations by mass spectrometry


Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column.
Microsaic Systems Plc


12/31/15
20150380233 

Ion trap mass spectrometer


A novel ms-ms apparatus utilizing electrostatic traps is disclosed, along with an associated method of analysis. The apparatus may include a chromatograph, an ion source, a first mass spectrometer, a fragmentation cell, an ion guide, a pulsed converter, and a z-directional elongated electrostatic trap.
Leco Corporation


12/31/15
20150380232 

Device allowing improved reaction monitoring of gas phase reactions in mass spectrometers using an auto ejection ion trap


A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. A second device is arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the collision or reaction region.
Micromass Uk Limited


12/31/15
20150380231 

Improved efficiency and precise control of gas phase reactions in mass spectrometers using an auto ejection ion trap


A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. The collision or reaction device further comprises a second device arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the first device without causing the first ions to be substantially ejected from the first device..
Micromass Uk Limited


12/31/15
20150380229 

Mass spectrometer


A mass spectrometer (1) is provided with: an ionization chamber (10) for ionizing a sample (s) on its surface at an analysis point through irradiation by a laser beam; an analysis chamber (23) having a mass spectroscope (24) for detecting ions; a middle vacuum chamber (21, 22) arranged between the ionization chamber (10) and the analysis chamber (23); and an introduction pipe (12) or an introduction hole for allowing the inside of the housing (11) of the ionization chamber (10) to communicate with the inside of the middle vacuum chamber (21), wherein ions and fine particles, which have not been drawn into the introduction pipe (12) or introduction hole, can be prevented from spreading inside of the chamber. The structure of the mass spectrometer (1) further includes: an exhaust pipe (13); and a fan (15) for drawing air into the exhaust pipe (13) so that air that contains ions and/or fine particles, which have not been introduced into the introduction pipe (12) or introduction hole, can be suctioned up into the exhaust pipe (13) when the fan (15) is in operation..
Shimadzu Corporation


12/31/15
20150380226 

Ionization chamber


An ionization chamber 100 is provided between a liquid chromatograph unit 60 and a mass spectrometer 50, and is formed of: an atomization means 15; and an ion introducing pipe 19 of which the entrance portion is created within the ionization chamber 100 in the horizontal direction that is perpendicular to the z direction and of which the exit portion is created within the mass spectrometer unit 50. A liquid sample that has been fed from the liquid chromatograph unit 60 is sprayed in the z direction by the atomization means 15 while being ionized within the ionization chamber 100, wherein the entrance portion has an opening in such a form that corresponds to the spread in the xy plane of the liquid sample sprayed in the z direction.
Shimadzu Corporation


12/24/15
20150371840 

Ion injection device for a time-of-flight mass spectrometer


The invention provides methods and devices to pulse ions from an rf ion storage into the flight tube of a time-of-flight mass spectrometer. The pusher cell comprises essentially two parallel plates, both plates completely slotted into two electrically insulated halves.
Bruker Daltonics, Inc.


12/24/15
20150371836 

Saturation correction for ion signals in time-of-flight mass spectrometers


The invention relates to time-of-flight mass spectrometers in which individual time-of-flight spectra are measured by detection systems with limited dynamic measurement range and are summed to sum spectra. The invention proposes a method to increase the dynamic range of measurement of the spectrum.
Bruker Daltonik Gmbh


12/24/15
20150369782 

Chromatograph/mass spectrometer data processing device


If multiple polyvalent ion peak candidates with different valences surmised to be derived from the target compound have been obtained, a mass chromatogram in the vicinity of the retention time of the target compound at the mass-charge ratio m/z of each polyvalent ion peak candidate is generated, and these are overlaid and displayed on the display screen. If the polyvalent ions are derived from the same compound, peaks of similar shape having a peak top near the retention time should appear in multiple mass chromatograms.
Shimadzu Corporation


12/17/15
20150364314 

Off-axis channel in electrospray ionization for removal of particulate matter


The present invention relates to electrospray ionization (esi) at atmospheric pressure coupled with a mass spectrometer, in particular to a special kind of micro-electrospray with liquid flows in the range of 0.1 to 100 microliters per minute. The invention describes the use of an off-axis pre-entrance channel in an esi ion source to prevent particulate matter with higher inertia than the (charged) gas molecules, such as droplets, from entering the mass spectrometer.
Bruker Daltonics, Inc.


12/17/15
20150364308 

Collision cell


A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis.
Thermo Fisher Scientific (bremen) Gmbh


12/17/15
20150364304 

Methods for acquiring and evaluating mass spectra in fourier transform mass spectrometers


The invention provides a method for acquiring a mass spectrum with a fourier transform mass spectrometer, wherein analyte ions and additional reporter ions oscillate at mass specific frequencies in a measuring cell of the frequency mass spectrometer and interact by coulomb forces; the image current signal induced by the reporter ion is measured; and mass signals of the analyte ions are determined from a sideband signal of the reporter ions in the frequency domain or from the instantaneous frequency of the reporter ions in the time domain.. .
Bruker Daltonik Gmbh


12/17/15
20150364303 

Methods of operating a fourier transform mass analyzer


A method is disclosed for operating a mass spectrometer having a fourier transform (ft) analyzer, such as an orbital electrostatic trap mass analyzer, to avoid peak coalescence and/or other phenomena arising from frequency-shifting caused by ion-ion interactions. Ions of a first group are mass analyzed, for example in a quadrupole ion trap analyzer, to generate a mass spectrum.
Thermo Finnigan Llc


12/17/15
20150362461 

System comprising a mass spectrometer coupled to a faims apparatus and methods of operation


A method of operating a system comprising a chromatograph and a mass spectrometer comprises: (a) providing an abundance threshold and a list comprising respective entries for precursor ion species of interest comprising respective precursor-ion m/z ratios; (b) transmitting a first sample fraction portion comprising a plurality of sample-fraction ion species through an ion mobility spectrometer operated in non-dispersive mode to the mass spectrometer; (c) detecting a respective abundance at each of a plurality of sample-fraction m/z ratios; and (d) upon detection of an above-threshold ion abundance at an m/z-ratio corresponding to a first precursor ion species of interest: (d1) inletting a second sample fraction portion into the ion mobility spectrometer operated in dispersive mode such that ions of the first precursor-ion species are preferentially transmitted therethrough; (d2) fragmenting the preferentially-transmitted ions so as to generate product ion species; and (d3) detecting the product ion species.. .
Thermo Finnigan Llc


12/10/15
20150357176 

Mass analysis device and mass separation device


A mass spectrometer (10) is configured from an ion source (1), an ion introduction unit (2), a mass analyzer (3), an ion detection unit (4), and the like. Crude ions are introduced into a separation space (5) at a predetermined acceleration voltage as a pulse synchronized with the phase of a one-dimensional high-frequency electric field.

12/10/15
20150357175 

Mass spectrometer with improved magnetic sector


The present invention relates to a compact and portable mass spectrometer device comprising a source of ions, a non-scanning magnetic sector for separating ions originating at the source of ions according to their mass-to-charge ratios, and a detection means. The magnetic sector comprises an ion entrance plane and at least two ion exit planes, which allow to optimize the resolving power of the mass spectrometer for specific mass-to charge ratio sub-ranges..
Luxembourg Institute Of Science And Technology (list)


12/10/15
20150357173 

Laser ablation atmospheric pressure ionization mass spectrometry


In an embodiment, the present invention provides an apparatus for mass spectrometry which includes a laser ablation sampler comprising a laser ablation chamber and a laser. The laser ablation chamber is configured so that the laser can irradiate and ablate a material from a sample to generate an ablated sample material.
WestfÄlische Wilhelms-universitÄt MÜnster


12/10/15
20150355155 

Method of measuring dissolved methane in seawater


Provided is a method of measuring dissolved methane in seawater, including: a) injecting a sample into a vacuum container containing a cadmium chloride solution injected thereinto and refrigerating the vacuum container; b) shaking the vacuum container, and achieving temperature equilibrium with an ambient temperature; c) separating the dissolved methane from residue by passing the sample in the vacuum container through a methane separator; and d) analyzing the separated dissolved methane by a mass spectrometer. According to the method of measuring dissolved methane in seawater of the present invention, a recovery rate of dissolved methane may be maximally increased to improve an analysis rate accordingly, and an analysis of dissolved methane may be conducted even with a small amount of sample, and in addition to the measurement of the dissolved methane, a sulfur isotope analysis may be simultaneously conducted by using a sample from which the dissolved methane is extracted..
Korea Institute Of Geoscience And Mineral Resources


12/10/15
20150355148 

Interfacing capillary electrophoresis to a mass spectrometer via an impactor spray ionization source


A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a capillary electrophoresis (“ce”) separation device.
Micromass Uk Limited


12/03/15
20150348770 

Mass spectrometer with optimized magnetic shunt


The present invention relates to a mass spectrometer device comprising a source of ions, an electrostatic sector, a non-scanning magnetic sector arranged downstream of the electrostatic sector, for separating ions originating at the source of ions according to their mass-to-charge ratios, and a detection means. A magnetic shunt is arranged in the drift space between the electrostatic sector and the magnetic sector.
Luxemburg Institute Of Science And Technology (lis


12/03/15
20150346214 

Detection of membrane proteins


According to the present invention, there is provided a method of detecting a membrane protein by mass spectrometry, the method comprising the steps of: (a) providing a solution comprising a detergent micelle in which said membrane protein is contained, wherein said solution contains a polyoxyalkylene glycol detergent; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the micelle; (d) ionising the membrane protein; (e) resolving the ionised membrane protein using the mass analyser; and (f) detecting the resolved membrane protein using the detector. Also provided are reagents for use in said method..

12/03/15
20150346186 

Integrated disease diagnostic system using matrix-assisted laser desorption/ionization time-of-flight mass spectrometer


A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (maldi-tof ms) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness.
Asta, Co. Ltd.


11/26/15
20150340219 

Integrated sample processing for electrospray ionization devices


Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one esi emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one esi emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one esi emitter thereby preferentially directing analyte molecules out of the at least one esi emitter.
The University Of North Carolina At Chapel Hill


11/26/15
20150340217 

Targeted analysis for tandem mass spectrometry


A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection tof device that separates ions into packets in accordance with their m/z.
Thermo Fisher Scientific (bremen) Gmbh


11/26/15
20150340215 

Diathermy knife ionisation source


A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife.
Micromass Uk Limited


11/26/15
20150340214 

Chemical sampling and detection methods and apparatus


This invention describes a sample collection and desorption device and method that collects residues of explosives and other chemicals from a surface and then introduces them into a detector. The desorption method and device include introducing additional chemicals while heating up the sample collector, thus, the collected sample may be converted via a chemical reaction or a catalytic process.

11/26/15
20150340212 

Tandem quadrupole mass spectrometer


A dwell time calculation table (51a) showing a correspondence relation between a cid gas pressure inside a collision cell (31) and a dwell time for data collection is stored in a processing condition parameter memory (51) of a controller (50). In the table (51a), as the cid gas pressure becomes higher, the dwell time becomes longer.
Shimadzu Corporation


11/26/15
20150337386 

Test composition for screening cancers


Provided in the present invention are a molecule for biomarking cancers and a test composition for screening cancers and a detection method thereof comprising designing a number of oligonucleotide primers or probes by analyzing specimens for methylated regions of targeted genes pax1, znf582, sox1 and nkx6-1 in physical examination, and then using the oligonucleotide probes to detect whether methylation exists in the target genes, and further judge the likelihood of the occurrence of cancer. The detection methods for methylation status include methylation-specific pcr, (msp), quantitative methylation-specific pcr (qmsp), bisulfate sequencing (bs), microarrays, mass spectrometer, denaturing high-performance liquid chromatography (dhplc), pyrosequencing, and enzyme-linked immunosorbent assay (elisa)..
Istat Biomedical Co., Ltd.


11/19/15
20150332904 

Parsing events during ms3 experiments


Systems and methods are provided for reducing the time period of a cid event of an ms3 experiment and making the overall fragmentation event more generic. A cid event of an ms3 experiment performed on a sample by a mass spectrometer is divided into two time periods using a processor.
Dh Technologies Development Pte. Ltd.


11/12/15
20150325424 

Method of assessing vacuum conditions in a mass spectrometer


A method is proposed for assessing the vacuum conditions in a mass spectrometer (10) such as an ion cyclotron resonance or orbital trapping mass spectrometer. Such mass spectrometers generate a transient detection signal resulting from ions of one or species in an ion trap (80).
Thermo Fisher Scientific (bremen) Gmbh


11/12/15
20150325421 

Droplet manipulation using gas-phase standing-wave ultrasound fields in ms sources


An ion source for a mass spectrometer is disclosed comprising an ionisation device which emits a stream of droplets and one or more ultrasonic transmitters which create one or more acoustic standing waves. The acoustic standing waves may be used to further nebulise the stream of droplets and induce internal mixing of the droplets..
Micromass Uk Limited


11/05/15
20150318162 

Segmented planar calibration for correction of errors in time of flight mass spectrometers


An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions.
Micromass Uk Limited


11/05/15
20150318161 

High pressure mass spectrometry systems and methods


Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.. .
908 Devices Inc.


11/05/15
20150318160 

Probe for extraction of molecules of interest from a sample


A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer.

11/05/15
20150318159 

Systems and methods for detection and quantification of selenium and silicon in samples


The present disclosure provides methods and systems for improved detection and/or quantification of selenium (se) and/or silicon (si) in samples. In certain embodiment, the methods and systems feature the use of carbon dioxide (co2) as a reaction gas in a reaction cell chamber, such as a dynamic reaction cell (drc), of an inductively coupled plasma mass spectrometer (icp-ms).
Perkinelmer Health Sciences, Inc.


11/05/15
20150318158 

Probe for extraction of molecules of interest from a sample


The present disclosure describes a device for generating ionized molecules for analysis in a mass spectrometer. The device includes: a mesh substrate coated with an extraction phase, the extraction phase comprising a polymer that absorbs a molecule of interest from a matrix, or a polymer and solid phase microextraction (spme) particles having pores dimensioned to absorb a molecule of interest from a matrix, where the mesh substrate has a sufficiently open structure to allow fluid to flow through the mesh substrate; and a solid substrate connected to the mesh substrate to provide stability to the coated mesh substrate.

11/05/15
20150318156 

Ion optical elements


Ion optics devices and related methods of making and using the same are disclosed herein that generally involve forming a plurality of electrode structures on a single substrate. An aspect ratio of the structures relative to a plurality of recesses which separate the structures can be selected so as to substantially prevent ions passing through the finished device from contacting exposed, electrically-insulating portions of the substrate.
Dh Technologies Development Pte. Ltd.


11/05/15
20150318155 

Method and improving ion transmission into a mass spectrometer


An ion transfer device for transferring ions emerging from an electrospray ion source at atmosphere to a vacuum chamber includes an inner surface in the shape of a diverging conical duct. The ion transfer device has an entrance aperture for positioning proximate the exit port of the electrospray ion source emitter, the entrance aperture receiving the electrosprayed ions from the exit port of the electrospray ion source emitter at atmosphere, the diverging conical duct being an electrode toward which the ions migrate and having an exit aperture with an inner diameter larger than an inner diameter of its entrance aperture, the exit aperture enclosed in the vacuum chamber, the diverging conical duct transporting the ions from atmosphere to vacuum.
The Rockefeller University


11/05/15
20150318154 

Scheduled ms3 for quantitation


Systems and methods are provided for scheduled ms3. A compound of interest is separated from a sample over a known time period using a separation device.
Dh Technologies Development Pte. Ltd.


10/29/15
20150311057 

Ion group irradiation device, secondary ion mass spectrometer, and secondary ion mass spectrometry method


The present invention provides an ion group irradiation device for irradiating a sample with an ion group. An ion group selecting unit is configured to select, from ions released from an ion source, at least two ion groups formed of ions having different average masses.
Canon Kabushiki Kaisha


10/29/15
20150311053 

Non-contact trace chemical screening


Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte.
Msdetection Corp.


10/29/15
20150311051 

Interlacing to improve sampling of data when ramping parameters


Systems and methods are provided for interlacing ramped mass spectrometer parameter values during data acquisition. Ions from a sample are acquired within a cycle time, ct, using a mass spectrometer.
Dh Technologies Development Pte. Ltd.


10/22/15
20150303045 

Compound identification using multiple spectra at different collision energies


Systems and methods are provided for compound identification using multiple spectra that are a function of a variable instrument parameter that affects the intensity of fragment ions. A plurality of acquired fragment ion spectra that are a function of a variable instrument parameter for at least one ion are received from a mass spectrometer using a processor.
Dh Technologies Development Pte. Ltd.


10/22/15
20150303043 

Intelligently controlled spectrometer methods and apparatus


The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (ims) and a mass spectrometer (ms) such that the obtained ims spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used..

10/22/15
20150303040 

Tungsten sintered compact sputtering target and tungsten film formed using said target


A tungsten sintered compact sputtering target, wherein a molybdenum strength detected with a secondary ion mass spectrometer (d-sims) is equal to or less than 1/10000 of the tungsten strength. This invention aims to reduce the specific resistance of a tungsten film sputtered using the tungsten sintered compact target by reducing the molybdenum in the tungsten sintered compact sputtering target and adjusting the grain size distribution of the w powder that is used during sintering..
Jx Nippon Mining & Metals Corporation


10/15/15
20150294849 

Multireflection time-of-flight mass spectrometer


A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location.

10/15/15
20150294847 

Mass spectrometer with soft ionizing glow discharge and conditioner


An ion detection system including an ion source and at least one ion detector is disclosed. The ion source includes a source housing, a reactor, first and second ionizers and a sampling channel.

10/15/15
20150294846 

Method of charge reduction of electron transfer dissociation product ions


A mass spectrometer is disclosed wherein highly charged fragment ions resulting from electron transfer dissociation fragmentation of parent ions are reduced in charge state within a proton transfer reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as octahydropyrimidolazepine.. .

10/15/15
20150293116 

Ionization of chemicals in mixture at low ph by ambient ionization/mass spectrometry


A mass spectrometry-based method for analyzing an acidic organic target compound includes directing a charged solvent (44) toward a pre-acidified sample (12) comprising the target compound, to thereby ionize the pre-acidified sample (12). The method further includes directing the ionized pre-acidified sample (54) to a mass spectrometer (18), the mass spectrometer (18) being configured to identify and quantify the target compound..

10/08/15
20150288013 

Online monitoring of fuel cell reactions by desorption electrospray mass spectrometry


A mass spectrometry-based method of directly online detecting fuel cell reaction products includes passing a reactant sample (16) through a fuel cell (12) to form reaction products that exit the fuel cell (12) in an output stream (26). The method also includes adding a derivatizing reagent (32) to the output stream (28) to form a derivatized output stream (34), wherein the derivatizing reagent (32) reacts with a potential reaction product to thereby form a derivatized reaction product if the potential reaction product is present.

10/08/15
20150287584 

Fast pushing time of flight mass spectrometer combined with restricted mass to charge ratio range delivery


Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a time of flight mass analyser. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time t1, wherein ions having the lowest mass to charge ratio in the first group of ions have a time of flight Δt1min through the time of flight region and ions having the highest mass to charge ratio in the first group of ions have a time of flight Δt1max through the time of flight region.

10/08/15
20150287582 

Ion source assembly for static mass spectrometer


An ion source assembly for a static mass spectrometer, comprises: a mounting element for locating the assembly within the static mass spectrometer; an ion source for generating ions to be analyzed in the static mass spectrometer, the ion source being spaced from the mounting element and arranged to be held in use at a first relatively high potential v1 with respect to the mounting element; and a spacer mounted between the mounting element and the ion source, the spacer arranged to be held in use at a second potential v2 with respect to the mounting element, which is less than the first potential v1.. .

10/08/15
20150287580 

High-voltage power unit and mass spectrometer using the power unit


An output terminal of a positive voltage generating circuit and an output terminal of a negative voltage generating circuit are connected in series, and an output terminal of the negative voltage generating circuit is connected to a ground via a resistor. A switching circuit and a series connection circuit of resistors are connected in parallel to each other between the output terminals of the positive voltage generating circuit and the negative voltage generating circuit.

10/08/15
20150287578 

Apparatus and sub-micrometer elemental image analysis by mass spectrometry


A mass spectrometer system for elemental analysis of a planar sample is provided. In some embodiments, the mass spectrometer system comprises: a primary ion source capable of irradiating a segment on planar sample with a beam of primary ions that is less than 1 mm in diameter, c) an orthogonal ion mass-to-charge ratio analyzer positioned downstream of sample interface, the analyzer being configured to separate secondary elemental atomic ions according to their mass-to-charge ratio by time of flight; d) an ion detector for detecting the secondary elemental atomic ions and producing mass spectra measurements; and e) a synchronizer, wherein the system is configured so that so that the beam of primary ions scans across the planar sample in two dimensions and the synchronizer associates the mass spectra measurements with positions on the planar sample..

10/08/15
20150285740 

Apparatus and determining the amounts of two or more substances present in a liquid


An apparatus for determining the total amount of two or more substances in a liquid, at least one of said substances comprising a fluorescent substance, said apparatus comprising: a mass spectrometer device; a fluorometer device; and a processing means; wherein said mass spectrometer device is adapted to obtain a periodic measurement of the total amount of said two or more substances in the liquid, said fluorometer device being adapted to detect the fluorescent response of said at least one fluorescent substance in said liquid to an excitation signal, said processing means being programmed to determine a calibration factor by comparing a measurement obtained by the fluorometer device with said periodic measurement of the total amount of said two or more substances present obtained by the mass spectrometer device, the processing means subsequently using said calibration factor to determine measurements representative of the total amount of both fluorescent and non-fluorescent substances present in the liquid based upon the fluorescent response detected by the fluorometer device.. .

10/01/15
20150279650 

Cylindrical multi-reflecting time-of-flight mass spectrometer


A method and apparatus are disclosed for improving resolution and duty-cycle of a multi-reflecting tof mass spectrometer (mr-tof) by arranging a cylindrical analyzer having an appropriate radial deflection means, means for limiting ion divergence in the tangential direction and a pulsed source providing ion packet divergence of less than 1 mm*deg. There are disclosed embodiments for fifth-order focusing cylindrical ion minors.
Leco Corporation


10/01/15
20150279648 

Laser desorption ionization mass spectrometry using a particulate separation bed


A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (maldi) for use with a mass spectrometer.
Purdue Research Foundation


10/01/15
20150279640 

Methods and increased ion throughput in tandem mass spectrometers


In a tandem mass spectrometry system, a first mass analyzer filters parent ions using a wide mass passband with a narrow rejection notch defined according to a modulation format. A wide mass range of parent ions is transmitted to an ion fragmentation device.
Agilent Technologies, Inc.


10/01/15
20150276771 

Method, composition, isolation and identification of a plaque particle and related biomarker


The disclosure relates to an in vitro technology of detecting presence of a plaque particle, isolating the plaque particle followed by its composition analysis in several diseases states or before the disease sets in. A mechanism and a process leading to plaque formation, identifying a component in the mechanism of plaque formation, an identification of a biomarker for diagnosis/early diagnosis of plaque associated disease is described.
Plaxgen Inc


09/24/15
20150270115 

Time-of-flight mass spectrometer


The thin electrodes suppress unevenness of potential, in particular, in a path away from the center axis of the reflector, which results in improvement of isochronism of an ion packet passing on the path. The thick electrodes (41, 43) disposed in the first stage region (s1) prevents stretching of the grid electrodes (g1, g2) from being affected, and unevenness of potential in the first stage region (s1) hardly affects isochronism of the ions.

09/24/15
20150270114 

Mass spectrometer with beam expander


A mass spectrometer is disclosed comprising a rf confinement device, a beam expander and a time of flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the rf confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the time of flight mass analyser..
Micromass Uk Limited


09/24/15
20150270113 

Sputter neutral particle mass spectrometry apparatus


A sputter neutral particle mass spectrometry apparatus includes a sample table holding a sample which is a mass spectrometry target, an ion beam irradiation device which irradiates an ion beam on the sample held by the sample table to generate neutral particles in an adjacent region of the sample, a light beam irradiation device which irradiates a light beam on the neutral particles positioned in the adjacent region to obtain photoexcited ions, a draw-out electrode which draws out the photoexcited ions, a mass spectrometer which draws in the drawn out photoexcited ions to perform mass analysis, and an optical element which is provided in a light path after the light beam passes the adjacent region, and changes a traveling direction of the light beam so that the light beam passes the adjacent region again.. .
Kabushiki Kaisha Toshiba


09/24/15
20150270112 

Sputter neutral particle mass spectrometry apparatus


A sputter neutral particle mass spectrometry apparatus includes a sample table holding a sample which is a mass spectrometry target, and comprising a temperature control mechanism for the sample, an ion beam irradiation device which irradiates an ion beam on the sample to generate neutral particles, a laser irradiation device which irradiates the neutral particles with a laser to obtain photoexcited ions, a mass spectrometer which draws in the drawn out photoexcited ions and performs mass analysis, a driving system mirror which is provided retractably on a laser light path between the laser irradiation device and the sample table, and reflects the laser when positioned within the laser light path, and, a profiler which is arranged in a reflective direction of the driving system mirror and detects a feature of the laser.. .
Kabushiki Kaisha Toshiba


09/24/15
20150270111 

Multiple ionization sources for a mass spectrometer


Systems and methods for a mass spectrometer include an atmospheric-pressure chemical ionization (apci) source, one or more low-pressure chemical ionization (lpci) sources, a mass analyzer configured to separate ions of a sample flow from the apci source and the one or more lpci sources, a detector configured to identify and quantify the received separated ions, and a plurality of valves configured to open and close associated input lines to the apci source and the one or more lpci sources, via a computer-implemented controller, and configured to maintain a vacuum environment of the mass spectrometer during the opening and closing.. .
Lockheed Martin Corporation


09/24/15
20150268203 

Mass spectrometer


An equation expressing a previously and experimentally determined relationship between the number of ions and a cv value is stored in a reference cv value calculation data memory. When mass spectrometry is performed for a target sample under measurement conditions including a loop time tp and a dwell time td, a chromatogram creator creates a chromatogram based on the analysis result and calculates a peak area value a.
Shimadzu Corporation


09/17/15
20150262807 

Mass spectrometer


An object of the present invention is to provide a mass spectrometer having a simple structure and being capable of precisely measuring a total pressure and performing mass spectrometry with high precision. A mass spectrometer according to one embodiment includes a quadrupole configured to selectively pass therethrough an ion of a target gas having a predetermined mass-to-charge ratio among components of a measurement gas ionized by an ion source, an ion detector configured to detect an ion current value based on the ion of the target gas that passes through the quadrupole, a total pressure measurer configured to detect a photoelectric current value based on vacuum ultraviolet light generated when the ion source ionizes the measurement gas, and an arithmetic unit configured to calculate a partial pressure of the target gas by using the photoelectric current value and the ion current value..
Canon Anelva Corporation


09/17/15
20150262806 

Mass spectrometer


Flanges (10a) of an attachment plate (10) integrally combined with an ion detector (5) are fixed to an inner surface of a vacuum chamber (1) via cushioning members (12), such as o-rings. Although the vacuum chamber (1) mechanically vibrates due to a turbomolecular pump attached to it, this vibration is absorbed by the cushioning members (12), whereby the vibration of the ion detector (5) is suppressed.
Shimadzu Corporation


09/17/15
20150262802 

Mass spectrometer


A method of switching between two modes of power supply to a mass analyser is provided. In a first mode of operation, operated for a first predefined time duration, a first power supply, coupled to the mass analyser, generates a first non-zero potential, whilst a second power supply, disconnected from the mass analyser, generates a second non-zero potential.
Thermo Fisher Scientific (bremen) Gmbh


09/17/15
20150262800 

Triple quadrupole mass spectrometer and non-transitory computer-readable medium recording a program for triple quadrupole mass spectrometer


A triple quadrupole mass spectrometer provided with: a calibration information storage section for storing mass calibration information showing the relationship between the mass-to-charge ratio and a calibration value, with a cid gas pressure as a parameter, for each measurement mode of an ms/ms analysis including a dissociating operation using a collision cell; and a controller for calibrating the mass-to-charge ratio of the ion to be detected by a detector, by reading, from the calibration information storage section, the mass calibration information corresponding to the measurement mode to be performed and a specified cid gas pressure and by driving each the front and rear quadrupoles and using that information.. .
Shimadzu Corporation


09/17/15
20150262799 

Tandem quadrupole mass spectrometer


A measurement condition memory stores a cid gas condition table indicating a relation between the scan speed of a mass scan by a front-stage quadrupole mass filter and a cid gas supply pressure. If the scan speed is high, an influence of a decrease in speed of ions due to collisions with a cid gas inside a collision cell is relatively large.
Shimadzu Corporation


09/17/15
20150260684 

Method and ion mobility spectrometry


Methods and systems for performing mass spectrometry are provided herein. The method includes ionizing one or more compounds to generate ions, passing the ions into an ion mobility spectrometer, providing ozone, reacting the ions with ozone to produce ozone-induced fragment ions, and performing mass analysis and detection of the ozone-induced fragment ions.
University Of Wollongong


09/17/15
20150260683 

Mass spectrometer


A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells.
Micromass Uk Limited




Mass Spectrometer topics: Mass Spectrometer, Spectrometer, Mass Spectrometry, Spectrometry, Downstream, Coordinates, Quantitative, Chromatograph, Data Processing, Biomolecule, Data Acquisition, Electrical Signal, Data Compression, Fragmentation, Irradiation

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