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Mammal

Mammal-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Improved anti-nuclear antibody detection and diagnostics for systemic and non-systemic autoimmune disorders
Immco Diagnostics, Inc.
June 22, 2017 - N°20170176454

Provided are compositions that contain mammalian cells for use in detecting antibodies. The mammalian cells are modified such that they do not contain ledgf protein. The mammalian cells are immobilized on a solid substrate. The compositions can also contain mammalian cells that contain the ledgf protein. Methods for using the cell compositions in diagnostic approaches are included, as are kits ...
Electrophysiological assays using oocytes that express human enac and the use of phenamil to improve ...
Senomyx, Inc.
June 22, 2017 - N°20170175160

In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (henac) cloned from a human kidney c-dna library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human enac modulators, preferably enac ...
Protein having nuclease activity, fusion proteins and uses thereof
Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (gmbh)
June 22, 2017 - N°20170175141

The present invention relates to a nucleic acid molecule encoding (i) a polypeptide having the activity of an endonuclease, which is (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of seq id no: 1; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of seq id no: 2; (c) a nucleic ...
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Methods for overcoming glutamine deprivation during mammalian cell culture
Samsung Bioepis
June 22, 2017 - N°20170175075

The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.
Modification of cupredoxin derived peptides and methods of use thereof
The Board Of Trustees Of The University Of Illinois
June 22, 2017 - N°20170174729

The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to use them to treat mammals suffering from various conditions related to the pharmacologic activities. Modifications of the cupredoxin derived peptides include amino acid sequence variants and structural derivations that increase the plasma half-life of the peptide, increase the specific activity of ...
Engineered cardiac derived compositions and methods of use
The Johns Hopkins University
June 22, 2017 - N°20170173215

The present invention establishes a new standard for investigative studies of patient-specific, genetic cardiac diseases at a functional, tissue level by creating a novel platform for the study of cardiac related diseases, including cardiac conduction dysfunction, arrhythmias and depressed contractility for example. Provided herein are novel compositions of human engineered heart slices (ehs) formed from thin slices of decellularized cardiac ...
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Compositions and methods of preventing erythropoietin associated hypertension
Enzymotec Ltd.
June 22, 2017 - N°20170173150

The invention also provides a method of reducing hypertension in a mammal receiving epo, and pharmaceutical compositions containing a soluble epo-bp and/or a recognition protein that binds epo receptor on an extracellular soluble portion of the epo receptor.
Compositions and methods for increasing the suppression of hunger and reducing the digestibility of non-fat ...
University Of Copenhagen
June 22, 2017 - N°20170173099

The present invention relates to methods for increasing the suppression of hunger and/or increasing the reduction of prospective consumption and/or increasing the reduction of appetite and/or increasing the feeling of satiety and/or reducing non-fat energy uptake in the gastrointestinal tract of a mammal in order to prevent a positive non-fat energy balance, weight gain, overweight and ...
Tungsten (vi) salts used to treat infertility, for stimulating fertility and normal reproduction in a ...
Oxolife, S.l.
June 22, 2017 - N°20170173074

The invention relates to tungsten (vi) salts for use thereof in the treatment of infertility in a non-diabetic female mammal, for favoring normal reproduction and fertility in a non-diabetic female mammal, or for increasing the efficacy of an assisted reproductive technique applied to a mammal, as well as compositions containing same and methods for treatment using same.
Compositions for the treatment of dermatological diseases and disorders
Oxolife, S.l.
June 22, 2017 - N°20170173056

The present disclosure is directed to topical dermatological formulations, dermatological cleansing compositions, and bathwater conditioners designed to acidify the skin, and their use for restoring epidermal acidity, restoring a the epidermal barrier, inhibiting inflammation, establishing an environment appropriate for maintaining a balanced symbiotic microbiome, and inhibiting the growth of pathogenic microorganisms in the epidermis—the outer layer of mammalian ...
Method and composition for increasing muscle protein synthesis and/or functional strength in mammals
Lonza Inc.
June 22, 2017 - N°20170173050

A method and composition for preserving muscle mass and function by increasing muscle protein synthesis and/or decreasing muscle protein degradation in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at least two of an essential amino acid, an amino acid derivative, and a nitrogenous organic acid. In a particular embodiment, the protein ...
Compositions and methods to treat addiction
The United States Government Represented By The Department Of Veterans Affairs
June 22, 2017 - N°20170173039

The present invention provides compositions and methods comprising talampanel and/or perampanel for treating or preventing an addictive disease or disorder, such as alcoholism, in a subject in need thereof. Ampa receptor (ampa-rs) antagonists (i. E., blockers), such as perampanel and talampanel, reduce drug and alcohol seeking behaviors in mammals since activation of glutamatergic ampa receptors promotes addictive behaviors in ...
Isoxazole treatments for frontotemporal dementia
The Board Of Regents Of The University Of Texas System
June 22, 2017 - N°20170172987

The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of frontotemporal dementia.
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Method of mitigating long term detrimental effects of exposure to medical imaging ionizing radiation by ...
Humanetics Corporation
June 22, 2017 - N°20170172976

Mitigation of long term detrimental effects of exposure to medical imaging ionizing radiation by administration of an amount of genistein in the form of a nano suspension to someone effective for achieving genistein serum levels of between 1-5 μm in the mammal throughout a time period from exposure to medical imaging ionizing radiation to twelve hours after exposure ...
Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using ...
Celonova Biosciences Germany Gmbh
June 22, 2017 - N°20170172933

Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Barium sulfate may also be provided to ...
Foamable composition combining a polar solvent and a hydrophobic carrier
Celonova Biosciences Germany Gmbh
June 22, 2017 - N°20170172857

The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.
Preventive or therapeutic agent for kidney disease
Miyazaki, Toru
June 22, 2017 - N°20170172120

The present invention provides a prophylactic or therapeutic agent for a kidney disease, comprising aim or a partial peptide thereof, or a nucleic acid comprising a base sequence encoding the same, or a screening method for a prophylactic or therapeutic agent for a kidney disease, comprising using an animal obtained by subjecting a non-human mammal deficient in aim expression to ...
Mammalian dickkopf 3 (dkk3) as urinary marker for chronic kidney diseases
Ruprecht-karls-universität Heidelberg
June 15, 2017 - N°20170168069

The present invention relates to dkk3 as a marker for diagnosing chronic kidney disease and assessing the risk of disease progression, as well as to related methods and uses. In particular, the present invention relates to method for diagnosing chronic kidney disease, comprising the steps of a) obtaining a urine sample comprising early morning urine (emu) from a mammalian, preferably ...
Mammalian cell in vitro topological neuron network
Ruprecht-karls-universität Heidelberg
June 15, 2017 - N°20170166857

A method of creating a three-dimensional surface topography network for the containment and growth of mammalian neuron cells for high throughput screening of potential biologically active drug compounds is provided. In the present disclosure a n×n array of wells is created on a carrier substrate that contains both wells and interconnected channels between wells to facilitate, in one ...
Antibodies against the rgm a protein and uses thereof
Abbvie Inc.
June 15, 2017 - N°20170166633

The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize rgm a protein. Specifically, these antibodies have the ability to inhibit the binding of rgm a to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting rgm a and for inhibiting rgm a activity, for example in a ...
Use of ddx3x inhibitors for the treatment of pneumovirus infections
University Of Warwick
June 15, 2017 - N°20170166519

The invention relates to a ddx3x inhibitorfor use in the treatment of pneumovirus infection in a mammal, wherein the ddx3x inhibitor may be a compound of formula (i) wherein y, z, r1, x, l, ra and rb are as defined herein. The invention also relates to compounds of formula (i).
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