Popular terms

Follow us on Twitter
twitter icon@FreshPatents

Web & Computing
Cloud Computing
Ecommerce
Search patents
Smartphone patents
Social Media patents
Video patents
Website patents
Web Server
Android patents
Copyright patents
Database patents
Programming patents
Wearable Computing
Webcam patents

Web Companies
Apple patents
Google patents
Adobe patents
Ebay patents
Oracle patents
Yahoo patents

[SEARCH]

Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications.



Date/App# patent app List of recent Mammal-related patents
01/28/16
20160028998 
 Methods, systems and devices for spinal surgery position optimization patent thumbnailMethods, systems and devices for spinal surgery position optimization
Three components are proposed, each having at its core a system for producing measurements of the relative motion of anatomical structures of mammals (the “measurement system”). The measurement system in this case would be comprised of an apparatus for imaging the joint of through a prescribed motion, and a process and mechanism for deriving quantitative measurement output data from the resulting images.
Ortho Kinematics, Inc.


01/28/16
20160027172 
 Method of monitoring the status of a wound patent thumbnailMethod of monitoring the status of a wound
A system for determining a clinically relevant temperature differential between a predetermined area of interest on the body surface of a mammal and a control area on the body surface of said mammal, said system comprising: a visual and thermal image capturing device, said image capturing device comprising: a housing, a means for capturing a digital visual image within said housing; and a means for capturing a digital thermal image within said housing; a display apparatus, said display apparatus comprising means for showing said captured visual image and said captured thermal image; and a computing apparatus, said computing apparatus operatively connected to said image capturing device and to said display apparatus, said computing apparatus comprising: a means for selecting a control area on the surface of the skin; a means for determining an temperature of said control area; a means for selecting an area of clinical interest within said visual image; a means for calculating plane geometric features of said selected area of clinical interest; a means for overlaying said digital image onto said thermal image in a desired orientation on said display apparatus; and a means for applying a unique pixel value to a specific predetermined temperature range on said thermal image.. .

01/28/16
20160027171 
 Method of monitoring the status of a wound patent thumbnailMethod of monitoring the status of a wound
A system for determining a clinically relevant temperature differential between a predetermined area of interest on the body surface of a mammal and a control area on the body surface of said mammal, said system comprising: a visual and thermal image capturing device, said image capturing device comprising: a housing, a means for capturing a digital visual image within said housing; and a means for capturing a digital thermal image within said housing; a display apparatus, said display apparatus comprising means for showing said captured visual image and said captured thermal image; and a computing apparatus, said computing apparatus operatively connected to said image capturing device and to said display apparatus, said computing apparatus comprising: a means for selecting a control area on the surface of the skin; a means for determining an temperature of said control area; a means for selecting an area of clinical interest within said visual image; a means for calculating plane geometric features of said selected area of clinical interest; a means for overlaying said digital image onto said thermal image in a desired orientation on said display apparatus; and a means for applying a unique pixel value to a specific predetermined temperature range on said thermal image.. .

01/28/16
20160025745 
 Methods of diagnosing and treating fibrosis patent thumbnailMethods of diagnosing and treating fibrosis
The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of ezh2 or yy-1.
University Of Rochester


01/28/16
20160025743 
 Method for the early detection of renal disease using proteomics patent thumbnailMethod for the early detection of renal disease using proteomics
A method for the detection of an early biomarker for assessing a change in renal status in a mammalian subject following a renal event. The method typically includes the steps of (a) providing a body fluid sample obtained from a mammalian subject; (b) analyzing the molecular weight of the proteins in the sample using proteome analysis; and (c) identifying the presence of a protein in the sample selected from the group consisting of a 6.4 kda protein, a 28.5 kda protein, a 33 kda protein, a 44 kda protein, a 67 kda protein, and combinations thereof.
Children's Hospital Medical Center


01/28/16
20160024578 
 Method for identifying the quantitative cellular composition in a biological sample patent thumbnailMethod for identifying the quantitative cellular composition in a biological sample
The present invention provides an epigenetic haemogram, also referred to as an epigenetic blood cell count that identifies the quantitative, comprehensive picture of cellular composition in a biological sample, wherein advantageously a normalization standard is used. The normalization standard is a nucleic acid molecule comprising at least one marker-region being specific for each of the blood cells to be detected, and at least one control-region being cell-unspecific, wherein said regions are present in the same number of copies on said molecule and/or a natural blood cell sample of known composition.
Epiontis Gmbh


01/28/16
20160024508 
 Method for identifying biologically active oligonucleotides capable of modulating the immune system patent thumbnailMethod for identifying biologically active oligonucleotides capable of modulating the immune system
The present invention relates to methods of identifying oligonucleotides capable of modulating the immune system in a mammalian subject, comprising analysis of which tertiary structural type said oligonucleotide adopts, in phosphate-buffered saline solution. Further, the invention provides oligonucleotides identifiable by the methods of the invention and to their use in methods of treating diseases, such as inflammatory diseases, autoimmune diseases, infectious diseases, neurodegenerative diseases and cancer..
Index Pharmaceuticals Ab


01/28/16
20160024502 
 Recombinant polypeptide production patent thumbnailRecombinant polypeptide production
Disclosed herein is a method for producing a recombinant polypeptide in a mammalian cell culture in which the mammalian cells have a modified microrna activity level. In one embodiment, a microrna activity level is increased.
Medlmmune, Llc


01/28/16
20160024480 
 Recombinant aav production in mammalian cells patent thumbnailRecombinant aav production in mammalian cells
The present invention includes methods and compositions for the production of high titer recombinant adeno-associated virus (raav) in a variety of mammalian cells. The disclosed raav are useful in gene therapy applications.
University Of Florida Research Foundation, Incorporated


01/28/16
20160024462 
 Method and device for producing a cell culture of human or animal cells patent thumbnailMethod and device for producing a cell culture of human or animal cells
The invention relates to a method for producing a cell culture (9) of human or animal cells, in particular mammalian cells, for the purpose of carrying out medical or pharmacological assays. According to the invention, the method comprises at least the following steps: inserting a substrate (3) of microbially produced cellulose into a vessel (1); introducing a nutrient solution (2) into the vessel (1); applying human or animal cells (4) to the substrate (3); conditioning the vessel contents to approximately body temperature; and waiting until the substrate (3) is completely covered by a cell lawn (5), i.e.
Xellutec Gmbh


01/28/16
20160024450 

Systems and methods for tissue processing and preparation of cell suspension therefrom


The present invention provides for methods and at least partially automated devices suitable for producing a transplantable cellular suspension of living tissue suitable for promoting tissue regeneration in an epithelium-related procedure, as well as compositions produced therefrom. Tissue regeneration in humans is extremely limited and constitutes a major challenge to the repair of damaged organ function.
Avita Medical Ltd.


01/28/16
20160024233 

Sequestrants of advanced glycation end product (age) precursors


Sequestrants of age precursors comprise amines separated by 2, 3 or 4 carbons. Sequestrants of age precursors can be used as pharmaceutical agents and in pharmaceutical compositions.
Genzyme Corporation


01/28/16
20160024217 

Production of proteins in glutamine-free cell culture media


The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture..
Genentech, Inc.


01/28/16
20160024104 

Therapeutic compounds


Or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula i, processes for preparing compounds of formula i, intermediates useful for preparing compounds of formula i and therapeutic methods for treating the proliferation of the hiv virus, treating aids or delaying the onset of aids or arc symptoms in a mammal using compounds of formula i..

01/28/16
20160024045 

Chiral compounds, compositions, products and methods employing same


Compounds that function, alone or in combination, as inhibitors of pigmentation for the improvement of mammalian skin are described herein. Specifically, the compounds of the present disclosure, namely chiral, non-racemic compounds, function as pigment formation inhibitors thereof to beautify skin and discourage the production of melanins.
Merz North America, Inc.


01/28/16
20160024044 

Inhibiting neurotransmitter reuptake


This document relates to compounds as well as methods and materials involved in modulating neurotransmitter reuptake. For example, compounds, methods for synthesizing compounds, and methods for inhibiting neurotransmitter reuptake are provided.
Virginai Tech Intellectual Properties, Inc.


01/28/16
20160022898 

Method for extracorporeal removal of pathogenic microbe, an inflammatory cell or an inflammatory protein from blood


The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.. .
Exthera Medical Corporation


01/28/16
20160022881 

Bioresorbable drug delivery matrices based on cross-linked polysaccharides, dosage forms designed for delayed/controlled release


Bioactive agents are embedded in a cross-linked dextran and coated with a bioresorbable polymer. When implanted in a mammal, the coated cross-linked dextran composition produces controlled release of the embedded bioactive agent..
Royer Biomedical, Inc.


01/28/16
20160022861 

Compositions having absorbable materials, methods, and applicators for sealing injuries


Disclosed are solid and frozen haemostatic materials utilizing an absorbable scaffolding material and consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings, particularly for the treatment of injured tissue via endoscopic or minimally-invasive surgical techniques..
Stb, Ltd.


01/28/16
20160022802 

Novel vaccines against multiple subtypes of dengue virus


An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prme that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are dna plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a dna plasmid and a pharmaceutically acceptable excipient, and methods of use thereof.
Inovio Pharmaceuticals, Inc.


01/28/16
20160022784 

Purine nucleoside phosphorylase as enzymatic activator of nucleoside prodrugs


A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a dna sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(β-d-arabinofuranosyl)-2-fluoroadenine (f-araa)..
Southern Research Institute


01/28/16
20160022758 

Agent derived from tortoise spleen stimulating mammalian hemopoiesis


The present invention relates to a proteinaceous extract derived from tortoise spleen and to a tetrapeptide ftgn, which have stimulatory activity on hematopoietic cells. In particular, this tetrapeptide enhances hemopoietic reconstruction, and bone marrow re-population, reduced as a consequence of a high dose of radiation or chemotherapy exposure.
Bmr Solutions Ltd.


01/28/16
20160022723 

Combination therapy for the treatment of proliferative diseases


A method of treating a proliferative disease, such as cancer, is disclosed. The method comprises administering to a mammal in need thereof synergistically therapeutically effective amounts of: (i) (2r,3s)—n-((3s)-1-methyl-2-oxo-5-phenyl-2,3-di-hydro-1h-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; (ii) 2-deoxy-2,2-difluorocytidine monohydrochloride (beta-isomer); and (iii) optionally, one or more additional anticancer agents..
Bristol-myers Squibb Company


01/28/16
20160022669 

Self-solidifying barrier implant and making the implant


Provided are bioerodible formulations that can be implanted into a cavity of a mammal as a liquid or semi-liquid and which solidifies upon exposure to body temperature of the mammal to form an implant. The implant erodes over a period of time and eluted a drug.

01/28/16
20160022635 

Use of arginine vasopressin receptor antagonists for the treatment of prostate cancer


Described herein are methods of decreasing the proliferation of prostate cancer cells in a mammalian subject by administering to a subject in need thereof a composition comprising an avpr antagonist in amount effective to decrease proliferation of the cancer cells. Also provided are methods of inducing prostate cancer cell death (or decreasing invasion migration of the prostate cancer cells) in a mammalian subject by administering to a subject in need thereof a composition comprising an avpr antagonist..
University Of Miami


01/28/16
20160022616 

Method for treating a pulmonary disease state in mammals by up regulating indigenous in vivo levels of inflammatory agents in mammalian cells


The present invention provides novel methods for treating a pulmonary disease state in mammals by up-regulating indigenous in vivo levels of an inflammatory agent in mammalian cells comprising contacting the mammalian cells with a therapeutically effective amount of an inflammatory regulator and a pharmaceutical agent. The inflammatory agent is selected from the group consisting of cytokines, transforming growth factor-β, elastase, and white blood cells, and wherein the inflammatory regulator is selected from the group consisting of pyruvates and pyruvate precursors.

01/28/16
20160022607 

Uses for idebenone and related benzoquinones in metabolic disorders and other ppar alpha/gamma related diseases and conditions


The present invention relates to the use of a 1,4-benzoquinone derived compound for the treatment of a disease or condition that is associated with peroxisome proliferator activated receptor (ppar) activity in a mammal.. .
Indanio Bioscience Inc.


01/28/16
20160022596 

Sustained-release formulations of topiramate


Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile.
Supernus Pharmaceuticals, Inc.


01/28/16
20160022449 

Tracheobronchial implantable medical device and methods of use


Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent.
Abbott Cardiovascular Systems, Inc.


01/28/16
20160022423 

Methods, systems, and devices for resizable intra-atrial shunts


Devices and methods for treating heart disease by normalizing elevated blood pressure in the left and right atria of a heart of a mammal are disclosed. Devices may include an adjustable hydraulic diameter and/or a removable and/or replaceable shunt portion.

01/28/16
20160022254 

Devices and methods for fixation of animal tissue


This document relates to tissue modification and, more particularly, to modification of biological tissue for implantation in a mammal. For example, this document relates to tissue tensioning devices and methods used during fixation of tissues for bioprosthetic heart valves..
Boston Scientific Scimed, Inc.


01/28/16
20160022206 

Multi-modal pharmaco-diagnostic assessment of brain health


A single diagnostic dose of a chemical agent that can bind with molecular specificity or provide a well characterized molecular effect on a mammalian host (including humans) is provided to a patient between brain scans. The method typically comprises at least one pre-dose scan of the subject followed by a waiting period then a second post-dose diagnostic scan.

01/21/16
20160018399 

Methods and materials for identifying and treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation


This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ascl1 and ret expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided..
Mayo Foundation For Medical Education And Research


01/21/16
20160018390 

Vitamin d assays


The disclosure relates to methods for measuring levels of 25(oh)vitamin d (250hd) in a mammalian fluid sample. The disclosure further relates to kits for measuring levels of 25(oh)vitamin d (250hd) in a mammalian fluid, the procedure comprising the step of release of the vitamin d from the serum binding protein (dbp), capturing of the released analyte by a specific antibody and competitive assay of the captured vitamin d against a conjugate between the vitamin d and a tracer.
Enzo Life Science, Inc.


01/21/16
20160017422 

Marker genes for oocyte competence


Cumulus cell (cc) gene expression is being explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes.
Vrije Universiteit Brussel


01/21/16
20160017372 

Methods and products for producing engineered mammalian cell lines with amplified transgenes


Methods of inserting genes into defined locations in the chromosomal dna of cultured mammalian cell lines which are subject to gene amplification are disclosed. In particular, sequences of interest (e.g., genes encoding biotherapeutic proteins) are inserted proximal to selectable genes in amplifiable loci, and the transformed cells are subjected to selection to induce co-amplification of the selectable gene and the sequence of interest.
Precision Biosciences, Inc.


01/21/16
20160017369 

Vector comprising multiple homologous nucleotide sequences


The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence.
Bavarian Nordic A/s


01/21/16
20160017321 

Method for expressing, secreting and transferring functional micrornas/sirnas and application thereof


The present invention relates to a microparticle comprising a functional microrna/sirna and application thereof. Specifically, disclosed is a use of a functional microrna and/or sirna, which is used to prepare a composition applied to a mammal.
Micromedmark Biotech Co., Ltd.


01/21/16
20160017291 

Microcarrier perfusion culturing methods and uses thereof


Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods.. .
Genzyme Corporation


01/21/16
20160017285 

Neural progenitor cell differentiation


Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ecm) compositions, such as collagen i, iv, laminin and/or a heparan sulfate proteoglycan. In one aspect of the invention, adult mammalian enteric neuronal progenitor cells can be induced to differentiate on various substrates derived from components or combinations of neural ecm compositions.
Wake Forest University Health Sciences


01/21/16
20160017280 

Perfusion culturing methods and uses thereof


Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods. Also provided are multi-well cell culture plates, e.g., for use in perfusion culturing methods..
Genzyme Corporation


01/21/16
20160017275 

Use of attenuated parasite strains for the prevention and/or treatment of eye wounds associated with an infection by toxoplasma gondii


Strains of toxoplasma gondii isolated from their natural environment for their use in the prevention and/or the treatment, in a mammal, of ocular lesions associated with an infection by an apicomplexan of the sarcocystidae family.. .
Universite Francois Rabelais De Tours


01/21/16
20160017033 

Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease


Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of their use for imaging senescent cells in vivo and for treating or preventing cancer, age-related disease, tobacco-related disease, or other diseases and disorders related to or caused by cellular senescence in a mammal. The methods include administering one or more of the agents of the invention to a mammal, e.g., a human.
Unity Biotechnology, Inc.


01/21/16
20160017011 

Phf20 and jmjd3 compositions and methods of use in cancer immunotherapy


Pharmaceutical compositions and methods for regulating somatic cell reprogramming in mammals, and in particular, for positively and negatively regulating cell reprogramming in human cells in vivo and in vitro. The invention also provides phf20-derived compositions and methods useful for cancer immunotherapies, including breast cancer therapies in particular..

01/21/16
20160017006 

Immunogenic fusion polypeptides


In one aspect, the invention relates to an isolated polypeptide including the amino acid sequence of a carrier polypeptide and the amino acid sequence of an orf2086 polypeptide. In another aspect, the invention relates to an immunogenic conjugate including orf2086 polypeptide and a carrier polypeptide.
Pfizer Inc.


01/21/16
20160016000 

Methods and compositions for treating ocular glaucoma


The invention provides a photodynamic therapy-based method for treating ocular glaucoma. A photosensitizer, for example, a benzoporphyrin derivative photosensitizer, is administered to a mammal either having or at risk of developing ocular glaucoma.
Massachusetts Eye And Ear Infirmary


01/21/16
20160015880 

Ventricular assist device for intraventricular placement


The present invention, in one embodiment, is a blood pump for intraventricular placement inside a heart of a mammalian subject including a rigid elongate member having a length between proximal and distal ends and a bore extending along the length, an anchor element connected towards the proximal end of the rigid elongate member and mounted to the subject's heart, a pump having an inlet and an outlet, a rotor and at least one electric drive coil for magnetically driving the rotor, the pump connected at or adjacent to the distal end of the rigid elongate member remote from the anchor element and wiring extending through the bore to the pump, wherein the proximal end of the rigid elongate member extends past the anchor element to a position outside of the subject's heart. Additional embodiments of a blood pump, and various methods of intraventricular placement inside a heart of a mammalian subject are also considered..
Heartware, Inc.


01/21/16
20160015878 

Implantation of a transapical ventricular assist device and kit for same


A method of implanting a blood pump in a heart of a mammalian subject includes maintaining a temporary plug in an inlet opening of a pump having a pump body and an outlet cannula projecting from the pump body, advancing the pump into a ventricle of the heart through a hole in a wall of the heart so that the inlet of the pump is disposed within the ventricle and the outlet cannula extends through a valve of the heart into an artery, and then withdrawing the temporary plug from the inlet of the pump.. .
Heartware, Inc.


01/21/16
20160015820 

Glycerophospholipids for the improvement of cognitive functions


The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of la, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) dha and epa which depend on utilizing different sources of lipids, and uses of such preparations.. .
Enzymotec Ltd.


01/21/16
20160015685 

Furo [3, 2-b] pyrr0l-3-0nes as cathespin s inhibitors


Compounds of formula (i) exhibit surprisingly high efficacies for human cathepsin s, excellent selectivity verses other mammalian cathepsins and are useful for treatment of diseases such as rheumatoid arthritis, multiple sclerosis, myasthenia gravis, transplant rejection, diabetes, sjogrens syndrome, grave's disease, systemic lupus erythematosis, osteoarthritis, psoriasis, idiopathic thrombocytopenic purpura, allergic rhinitis, asthma, atherosclerosis, obesity, chronic obstructive pulmonary disease and chronic pain.. .

01/21/16
20160015050 

Vegetable oil composition containing palm mid-fraction fat and reducing plasma cholesterol


A method and composition for reducing the cholesterolemic effect in mammals of ingesting a blended nutritional fat composition containing a palm mid-fraction (pmf) hardstock fat combined with an unsaturated vegetable oil. The composition is solid or semi-solid at 20° c.
Brandeis University


01/14/16
20160010162 

Biomarker panels for predicting prostate cancer outcomes


This document provides methods and materials related to assessing male mammals (e.g., humans) with prostate cancer. For example, methods and materials for predicting (1) which patients, at the time of psa reoccurrence, will later develop systemic disease, (2) which patients, at the time of retropubic radial prostatectomy, will later develop systemic disease, and (3) which patients, at the time of systemic disease, will later die from prostate cancer are provided..
Mayo Foundation For Medical Education And Research


01/14/16
20160010058 

Methods of producing enriched populations of tumor-reactive t cells from tumor


Methods of obtaining a cell population enriched for tumor-reactive t cells, the method comprising: (a) obtaining a bulk population of t cells from a tumor sample; (b) specifically selecting cd8+ t cells that express any one or more of tim-3, lag-3, 4-1bb, and pd-1 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive t cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive t cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive t cells, and isolated or purified cell populations are also disclosed..
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


01/14/16
20160009809 

Veterinary composition and improving livability of animals, promoting live weight gain in mammals and birds, enhancing the effectiveness of immunization, and preventing and/or treating infectious diseases


The present application provides a veterinary composition comprising an activated-potentiated form of an antibody to insulin receptor which can be used for improving livability of animals, primarily, promoting live-weight gain and growth of mammals and birds (preferably food-producing animals and poultry), enhancing the effectiveness of immunization, preventing and/or treating a broad range of diseases (including infectious diseases of various etiology), and increasing livestock performance, reproduction and survival.. .

01/14/16
20160009753 

Reducing risk of contracting clostridium-difficile associated disease


A method of treating a patient to reduce risk of developing clostridium difficile-associated disease or reducing existing clostridium difficile-associated disease in a mammalian subject involves administering to a mammalian subject an effective amount of a germination-inhibiting compound derived from taurocholate. Novel compounds of this class are also provided..
The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of


01/14/16
20160008471 

Transdermal formulations


The present invention relates to a non-aqueous composition that comprises a permeation enhancer such as a terpene, for delivering an active ingredient transdermally. The composition comprises at least on one active ingredient, a terpene, and a solvent, such as a non-hydroxyl containing solvent, non-heterocyclic ester solvent and/or a tripropylene glycol alkyl ether.

01/14/16
20160008462 

Veterinary composition and improving livability of animals, promoting live weight gain in mammals and birds, enhancing the effectiveness of immunization, and preventing and/or treating infectious diseases (variants)


The present application provides a pharmaceutical composition comprising a) an activated-potentiated form of an antibody to human insulin receptor and b) an activated-potentiated form of an antibody to human interferon gamma, which can be used for improving livability of animals, primarily, promoting live-weight gain and growth of mammals and birds (preferably food-producing animals and poultry), enhancing the effectiveness of immunization, preventing and/or treating a broad range of diseases (including infectious diseases of various etiology), and increasing livestock performance, reproduction and survival.. .

01/14/16
20160008436 

Methods of controlling parasitic worms in animals


Disclosed herein are methods of controlling parasitic worms in herbivorous mammals and other species by orally administering an isolated antibody that specifically binds the interleukin-10 peptide or an interleukin-10 peptide. In the case of herbivorous mammals such as cattle, for example, administration of the anti-il-10 antibodies increases weight gain and increases feed efficiency in the animals..
Wisconsin Alumni Research Foundation


01/14/16
20160008402 

Adipose tissue-derived stem cells for veterinary use


The invention provides for compositions and methods for making and using adipose-derived stem cells for treating non-human mammals for various medical conditions.. .
Cell4vet Corporation


01/14/16
20160008400 

Methods of producing enriched populations of tumor reactive t cells from peripheral blood


Methods of obtaining a cell population enriched for tumor-reactive t cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (pbmcs) from a sample of peripheral blood; (b) specifically selecting cd8+t cells that also express pd-1 and/or tim-3 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive t cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive t cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive t cells, and isolated or purified cell populations are also disclosed..
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services


01/14/16
20160008396 

Rare earth metal compounds, methods of making, and methods of using the same


Rare earth metal compounds, particularly lanthanum, cerium, and yttrium, are formed as porous particles and are effective in binding metals, metal ions, and phosphate. A method of making the particles and a method of using the particles is disclosed.
Spectrum Pharmaceuticals, Inc.


01/14/16
20160008395 

Process for the preparation of a non-corrosive base solution and methods of using same


The present invention provides novel methods of making a non-corrosive base solution for use as an alkalinity increasing agent and/or antioxidant. The present invention further provides novel compositions and methods which can be used to provide relief from disorders related to or complicated by acidosis or excessive free radical or other reactive oxygen species production including, but not limited to, gout, lesch-nyhan syndrome, hemochromatosis, alzheimer's, amyotropic lateral sclerosis, arthritis, atherosclerosis, cancer, cataracts, chronic obstructive pulmonary disease, diabetes, cellulitis, coronary artery disease, heart failure, hypertension, inflammatory bowel disease, macular degeneration, multiple sclerosis, parkinson's, reynaud's phenomenon, reperfusion injury, pancreatic impairment, skin infections, hepatitis c, methicillin-resistant staphylococcus aureus and infection.

01/07/16
20160004957 

Computer-implemented simulated intelligence capabilities by neuroanatomically-based system architecture


Computer-implemented systems for simulated intelligence information processing comprising: a digital processing device comprising an operating system configured to perform executable instructions and a memory; a computer program including instructions executable by the digital processing device to create a hierarchical software architecture comprising: a software module for providing a functional interpretation of the prosencephalon, or parts thereof; a software module for providing a functional interpretation of the mesencephalon, or parts thereof; and a software module for providing a functional interpretation of the rhombencephalon, or parts thereof; wherein the software architecture simulates vertebrate, mammalian, primate, or human neuroanatomy. In some embodiments, the systems create simulated intelligence..
Simigence, Inc.


01/07/16
20160003803 

A screening method, a kit, a treatment and a compound for use in a treatment


A method of screening for a candidate compound for the treatment of a condition involving dysregulation of metabolism in a mammal, said method comprising bringing a compound into contact with at least one population of cells, comprising cells that express mtor and akt and that are capable of activating mtorc2 and akt; determining mtorc2 activity and akt activity in cells brought into contact with the compound, and identifying the candidate compound based on the determined mtorc2 activity and akt activity. A kit for use in such a method of.
Atrogi Ab


01/07/16
20160002728 

Means and methods for haplotyping mhc-drb loci in mammals and uses thereof


The invention relates to the typing of mhc-drb loci in mammals. In particular, the invention provides a typing procedure for the mammalian drb region that allows an easy, economical, high resolution, fast and accurate haplotyping protocol.
Stichting Biomedical Primate Research Centre


01/07/16
20160002643 

Compositions and methods to enhance protein expression


The present invention relates to methods, compositions and kits for increasing expression of transfected genes through the use of super-induction nucleic acid sequences, including highly structured rna. In particular, co-transfection of super-induction nucleic acid sequences including, for example, shrna encoding sequences, retroviral elements, and (in other embodiments) va-rna encoding sequences, is contemplated for enhancing the expression of co-transfected transgenes in a cell.
The Board Of Regents, The University Of Texas System


01/07/16
20160002629 

Diagnostic and treatment for chronic and acute phase myeloid leukemia


Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form. Also provided are methods of reducing proliferation or promoting differentiation of a cancer cell having reduced level of numb or increased level of msi.
Duke University


01/07/16
20160002594 

Microcarrier perfusion culturing methods and uses thereof


Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods.. .
Genzyme Corporation


01/07/16
20160002592 

Formulations and methods for increased recombinant protein production


Formulations and methods to increase the production of recombinant proteins, and other aspects, are disclosed. The formulations and methods relate to increasing mannose or calcium concentration, or both, in a cell culture medium formulation for culturing cells that express recombinant proteins.
Bayer Healthcare Llc


01/07/16
20160002328 

Methods of treating kawasaki disease using il-1beta antibodies


This invention relates to a novel use of il-1β-ligand/il-1 receptor disrupting compounds (herein referred to as “il-1beta compounds”); such as small molecular compounds disrupting il-1b ligand-il-1 receptor interaction, il-1b antibodies or il-1 receptor antibodies, e.g. Il-1b binding molecules described herein, e.g.
Novartis Ag


01/07/16
20160002324 

Anti-ngf antibodies and their use


The present disclosure encompasses ngf binding proteins, specifically to antibodies that are chimeric, cdr grafted and canonized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting ngf and for inhibiting ngf activity, e.g., in a mammal subject suffering from a disorder in which ngf activity is detrimental..
Zoetis Belgium S.a.


01/07/16
20160002232 

Substituted n-(1h-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as type iii receptor tyrosine kinase inhibitors


Compounds useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.. .
Array Biopharma Inc.


01/07/16
20160002160 

Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same


Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2′-methyl-1,1-biphenyl-4-yl) carbonyl]pyrrolidin-3-one o-methyloxime is disclosed. A pharmaceutical composition containing the crystalline compound and methods for treating conditions related to the ot-r activity, such as preterm labor, and tor increasing embryo implantation rate in a mammal undergoing embryo transfer, comprising administering the crystalline compound are also disclosed..
Obseva Sa


01/07/16
20160000945 

Methods for evaluating brain-wide paravascular pathway for waste clearance function and methods for treating neurodegenerative disorders based thereon


Methods are provided for measuring glio-vascular pathway (“glymphatic system”) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (csf-isf) exchange in the brain. The methods can be used to track the exchange between csf and isf compartments.
The Research Foundation For The State University Of New York


01/07/16
20160000930 

Methods and compositions for targeting adipose cells in mammals


Methods and compositions are presented for use in diagnostic, imaging or targeting of therapeutic agents to treat obesity/adiposity-associated disorders, compositions and methods identify and use peptides to selectively target adipose tissue stromal cells in mammals.. .
Board Of Regents, The University Of Texas System


01/07/16
20160000859 

Peptide additives for enhancing acceptance and ingestion of edibles by rodents and uses thereof


Methods of using of guanylin family peptides to induce food or odor preferences in mammals are provided, along with methods for inducing feeding responses in mammals, and methods of controlling pest populations of mammals, such as rodents.. .
University Of Maryland, Baltimore


01/07/16
20160000858 

Compositions and methods for mitigating skin irritation and enhancing skin barrier function


Methods and compositions for cell regeneration and decreased irritation of mammalian skin cells are provided, wherein the compositions include a synergistic combination of two or more oligopeptides. The compositions may advantageously be applied to mammalian skin to effect a regeneration of skin cells and to effect a reduction in inflammation and redness experienced by the skin.
Gojo Industries, Inc.


01/07/16
20160000817 

Treatment of ocular disorders


The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a very late antigen-4 (vla-4) antagonist for the treatment of selected ocular disorders.. .
Massachusetts Eye And Ear Infirmary


01/07/16
20160000803 

Pharmaceutical composition for transmucosal administration of benzodiazepines


The current application relates to a liquid pharmaceutical composition for intraoral transmucosal administration of a benzodiazepine drug to a mammal. The composition comprises a physiologically acceptable hydrophobic phase, an eutectic mixture of benzodiazepine compound providing high solubility of the benzodiazepine in said hydrophobic phase, at least one physiologically acceptable organic solvent and at least one physiologically acceptable surfactant..
Eastgate Pharmaceuticals Inc.


01/07/16
20160000793 

Sodium channel blocker for treatment of loss of superficial sensitivity


The invention concerns a sodium channel blocker for the treatment of a reduction or loss of superficial sensitivity or sense of touch of a human being or another mammal. .
Phytotox Limited


01/07/16
20160000755 

Compositions and methods to improve adoptive cell therapies


Compositions and methods of enhancing the potency and efficacy of adoptive cell therapy using integrin-ligand stabilizers, wherein the integrin is selected from the group consisting of α4β1, α5β1, α4β7, αvβ3 and αlβ2, and contacting the effector cells ex vivo with agonists or stabilizers having the general formula (i); methods of treating integrin-expressing cells with such stabilizers to enhance tumor infiltration; and therapeutic methods comprising administering stabilizer or agonist-treated cells to a mammal requiring treatment of solid tumors, hematologic cancers.. .
7 Hills Interests Llc


01/07/16
20160000702 

Pharmaceutical composition for enhanced transmucosal adminstration of benzodiazepines


The current application relates to a liquid pharmaceutical composition for intiaoral transmucosal administration of a benzodiazepine drag to a mammal the composition comprises a physiologically acceptable hydrophobic phase, a eutectic mixture of benzodiazepine compound providing high solubility of the benzodiazepine in said hydrophobic phase, at least one physiologically acceptable organic solvent and at least one physiologically acceptable surfactant.. .
Eastgate Pharmaceuticals Inc.


01/07/16
20160000684 

Methods of reducing or eliminating tooth staining by application of stain barrier films


The invention includes methods for reducing or preventing the staining capacity of a compound to a tooth in a mammalian oral cavity, which includes affixing to the tooth surface a degradable film. The film comprises a starch polymer or copolymer that is formed by crosslinking a starch.
Hegemon Enterprises, Llc


01/07/16
20160000612 

Device and applying pressure to a mammalian limb


A therapeutic pressure band for applying pressure across a muscle or muscle groups on a mammalian limb is described. The band is particularly well suited for treating “shin splints.” the band includes a plurality of straps that are connected together via a connecting material.

01/07/16
20160000105 

Lactase containing milk powder


The present invention relates to milk powder compositions comprising lactase and to processes for the manufacture of the milk powder compositions. The processes have been found to stabilize lactase in the milk powder compositions.
Nestec S.a.


12/31/15
20150376683 

Methods of detecting chlamydia and gonorrhea and of screening for infection/inflammation based on genomic copy number


Compositions and methods for detecting chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) are provided. The present invention also provides methods and compositions for screening for infection/inflammation based on genomic copy number.
Cepheid


12/31/15
20150376670 

Dna templates for small rna production in mammalian cells


This disclosure describes unique single stranded dna templates having a characteristic sequence and secondary structure. The dna templates disclosed herein are useful for making small rna molecules through promoterless transcription by a mammalian rna polymerase, and can serve as an effective vector for producing small rna molecules of interest in vitro, in situ and in vivo in mammalian cells..
Research Foundation Of The City University Of New York


12/31/15
20150376652 

Gene editing in the oocyte by cas9 nucleases


The present invention relates to a method of producing a non-human, mammalian oocyte carrying a modified target sequence in its genome, the method comprising the steps of introducing into a non-human, mammalian oocyte: (a) a clustered, regularly interspaced, short palindromic repeats (crispr)-associated protein 9 (cas9 protein) or a nucleic acid molecule encoding said cas9 protein; and (b-i) a target sequence specific crispr rna (crrna) and a trans-activating crrna (tracr rna) or a nucleic acid molecule encoding said rnas; or (b-ii) a chimaeric rna sequence comprising a target sequence specific crrna and tracrrna or a nucleic acid molecule encoding said rna; wherein the cas9 protein introduced in (a) and the rna sequence(s) introduced in (b-i) or (b-ii) form a protein/rna complex that specifically binds to the target sequence and introduces a single or double strand break within the target sequence. The present invention further relates to the method of the invention, wherein the target sequence is modified by homologous recombination with a donor nucleic acid sequence further comprising the step: (c) introducing a nucleic acid molecule into the cell, wherein the nucleic acid molecule comprises the donor nucleic acid sequence and regions homologous to the target sequence.
Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt


12/31/15
20150376651 

Methods and compositions for targeted genetic modifications and methods of use


Methods and compositions are provided for generating targeted genetic modifications on the y chromosome or a challenging target locus. Compositions include an in vitro culture comprising an xy pluripotent and/or totipotent animal cell (i.e., xy es cells or xy ips cells) having a modification that decreases the level and/or activity of an sry protein; and, culturing these cells in a medium that promotes development of xy f0 fertile females.
Regeneron Pharmaceuticals, Inc.


12/31/15
20150376647 

Designer ph sensor as universal transgene controller


The invention relates to vectors and mammalian cells in a system useful for switching on or switching off gene expression in response to ph and gaseous carbon dioxide, taking advantage of signal transduction of the human proton-activated cell-surface receptor tdag8, ogr1 and/or gpr4 and related receptors to chimeric promoters containing camp-response elements. The systems according to the invention can be used to precisely monitor culture ph within the physiologic range, or also to adjust expression by gaseous c02 which shifts the c02-bicarbonate balance towards hydrogen ions.
Eth Zurich


12/31/15
20150376621 

Modified small interfering rna molecules and methods of use


The present invention provides double-stranded rna molecules that mediate rna interference in target cells, preferably hepatic cells. The invention also provides double-stranded rna (dsrna) molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis c virus (hcv).
Arrowhead Research Corporation


12/31/15
20150376584 

Methods of treating viral infections, particularly rabies, mers-cov, influenza, ebola, chikungunya, venezuelan equine encephalitus, canine parvovirus, adenovirus, respiratory syncytial virus, rhinovirus, and poxvirus in mammalian patients


Viral infections in mammals can be treated and prophylactically prevented by systemic administration of ranpirnase and three other ribonucleases that are highly homologous with it and that have activities that are highly similar to it. Experimental results against rabies, middle east respiratory syndrome coronavirus (“mers-cov”), influenza, ebola virus, chikungunya virus, venezuelan equine encephalitis, canine parvovirus, adenovirus-2, respiratory syncytial virus, rhinovirus-14, and vaccinia are disclosed..
Tamir Biotechnology, Inc.


12/31/15
20150376264 

Bovine fusion antibodies


Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (cdr3h) or fragment thereof; and a therapeutic polypeptide attached to or inserted into the cdr3h.
The California Institute For Biomedical Research


12/31/15
20150376255 

Aquaretic and natriuretic polypeptides lacking vasodilatory activity


This document provides aquaretic and natriuretic polypeptides. For example, this document provides polypeptides having aquaretic and/or natriuretic activities.
Mayo Foundation For Medical Education And Research


12/31/15
20150376250 

Compositions and methods for the delivery of oxygen


H-nox proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas o2 delivery. The engineered h-nox proteins comprise mutations that impart altered o2 or no ligand-binding relative to the corresponding wild-type h-nox domain, and are operative as physiologically compatible mammalian blood o2 gas carriers.
The Regents Of The Univesity Of California


12/31/15
20150376241 

Flagellin related polypeptides and uses thereof


The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.. .
Cleveland Clinic Foundation


12/31/15
20150376178 

Pyridinoylpiperidines as 5-ht1f agonists


The compounds of the present invention are useful for activating 5-ht1f receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of formula i..

12/31/15
20150376109 

Compositions and methods of use of phorbol esters for treatment of stroke


Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects..

12/31/15
20150374851 

Aav vectors expressing sec10 for treating kidney damage


A method for enhancing repair of damaged mammalian tubular epithelial cells involves delivering to the tubular epithelial cells of a subject in need thereof a composition comprising an adeno-associated virus (aav) comprising an aav capsid having an amino acid sequence of a selected aav serotype, and a minigene having aav inverted terminal repeats and a sec10 gene operatively linked to regulatory sequences that direct expression of sec10 in the epithelial cells. In one embodiment, delivery is accomplished by retrograde intrauretal injection.
The Trustees Of The University Of Pennsylvania


12/31/15
20150374811 

Protein antigens that provide protection against pneumococcal colonization and/or disease


The present application is generally directed to novel pneumococcal polypeptide antigens and nucleic acids encoding such antigens, and immunogenic compositions comprising such antigens for treating and preventing pneumococcal infection. The present invention further provides method of using the antigens to elicits an immune response (e.g., il-17a response, a t cell-mediated and/or b-cell-mediated immune responses).
Children's Medical Center Corporation


12/31/15
20150374799 

Protein to promote blood vessel growth and uses thereof


A method for stimulating angiogenesis in a tissue of a mammal comprising contacting tissue with a protein substantially similar to pyruvate kinase m2.. .
Georgia State University Research Foundation


12/31/15
20150374793 

Diuretic and natriuretic polypeptides


This document provides diuretic and natriuretic polypeptides. For example, this document provides polypeptides having diuretic and/or natriuretic activities.
Mayo Foundation For Medical Education And Research


12/31/15
20150374791 

Protein therapy for treatment of retinal diseases


The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes polypeptides that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties, and their application in the treatment of eye disease, particularly diseases of the retina.
The Texas A&m University System


12/31/15
20150374787 

Method for administering omega-conopeptide


The present invention is directed to a method of producing analgesia in a mammalian subject. The method includes administering to the subject an omega conopeptide, preferably ziconotide, in combination with an analgesic selected from the group consisting of morphine, bupivacaine, clonidine, hydromorphone, baclofen, fentanyl 1, buprenorphine, and sufentanil, or its pharmaceutically acceptable salts thereof, wherein the ω-conopeptide retains its potency and is physically and chemically compatible with the analgesic compound.
Jazz Pharmaceuticals International Limited


12/31/15
20150374780 

Compositions and methods to prevent cancer with cupredoxins


The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28).
The Board Of Trustees Of The University Of Illinois


12/31/15
20150374773 

Homeopathic composition comprising hypericum perforatum extract and essential oils for the treatment of neuropathic pain


The present invention provides a method of treating neuropathic pain by administering a topical homeopathic composition to a mammalian subject. The homeopathic formulation contains homeopathic active ingredients comprising hypericum perforatum in a base of essential oils which facilitate delivery of the homeopathic ingredient through the skin..
Neuragen Corp.


12/31/15
20150374704 

Combined systemic and topical treatment of disordered and/or prodromal stage tissue


Compositions and methods for treating disordered and/or prodromal stage tissue infected with by a virus in a mammal by co-administering a systemic anti-virus drug and topically administered anti-infective composition. The systemic anti-virus drug is internally administered and disrupts or inhibits virus replication systemically within the mammal.
Quadex Pharmaceuticals, Llc


12/31/15
20150374659 

Composition and treating tinnitus


A method of treating tinnitus includes the step administering a composition to the mammal, wherein the composition consists essentially of a biologically effective amount of vitamin a, vitamin e, vitamin c, a vasodilator comprising magnesium, and, optionally, a withanolide, and/or resveratrol.. .
The Regents Of The University Of Michigan


12/31/15
20150374656 

Compositions and methods of use of phorbol esters


Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of cytopathic diseases. Cytopathic diseases may be caused by a variety means such as viral infections like hiv and aids, or the development of neoplasms in a mammalian subject.

12/31/15
20150374598 

Treatment and modulation of gene expression and skin aging


Methods and compositions for treating modulating and/or ameliorating non-light-induced, particularly non-uv-induced, skin aging in a human, for reducing the basal mmp-10 expression in unirradiated cells of an organism and/or reducing the basal mmp-1 rna transcription and protein translation in unirradiated cells of an organism, and/or for modulating the effects of uva-induced rna transcription and polypeptide translation of a matrix metalloprotease, which include administering an effective amount of β-carotene, a precursor of β-carotene, a salt of β-carotene, or a combination of two or more thereof to an organism, particularly a mammal, more particularly a human, in need thereof.. .
Dsm Nutritional Products Ltd.






Follow us on Twitter
twitter icon@FreshPatents

###

This listing is a sample listing of patent applications related to Mammal for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mammal with additional patents listed. Browse our RSS directory or Search for other possible listings.


2.2832

4628

3 - 0 - 110