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Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications. Subscribe to the Mammal RSS feed to automatically get the update: related Mammal RSS feeds. RSS updates for this page: Mammal RSS RSS


Devices and systems for navigation and positioning a central venous catheter within a patient

Bard Access Systems

Devices and systems for navigation and positioning a central venous catheter within a patient

Date/App# patent app List of recent Mammal-related patents
03/19/15
20150080855
 Systems, devices, and methods for localized drug delivery patent thumbnailSystems, devices, and methods for localized drug delivery
Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ.
Dtherapeutics, Llc
03/19/15
20150080762
 Devices and systems for navigation and positioning a central venous catheter within a patient patent thumbnailDevices and systems for navigation and positioning a central venous catheter within a patient
Devices and systems for navigation and positioning a central venous catheter within a patient. In an exemplary embodiment of a system of the present disclosure, the system comprises a first pole and a second pole, the first pole and the second pole configured to generate an electric field within a mammalian body sufficient to obtain a plurality of field measurements therein, and an elongated body configured for at least partial insertion into a blood vessel of the mammalian body and advancement through a vasculature, said advancement dependent upon the plurality of field measurements indicative of one or more locations of a portion of the elongated body within the vasculature.
Bard Access Systems, Inc.
03/19/15
20150080368
 Sulfonyl amide derivatives for the treatment of abnormal cell growth patent thumbnailSulfonyl amide derivatives for the treatment of abnormal cell growth
Wherein r1 to r6, a, b, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals.
03/19/15
20150080334
 Maternal supplement to enhance immune system of an infant patent thumbnailMaternal supplement to enhance immune system of an infant
There is provided compositions and methods for enhancing an immune system and/or preventing an immune system related disorder in a mammalian subject, the composition comprising a non-digestible oligosaccharide which is to be administered to a female who is breast-feeding the mammalian subject.. .
N.v. Nutricia
03/19/15
20150080311
 Compound and  treating myotonic dystrophy patent thumbnailCompound and treating myotonic dystrophy
An antisense compound for use in treating myotonic dystrophy dm1 or dm2, a method of enhancing antisense targeting to heart and quadricep muscles, and a method for treating dm1 or dm2 in a mammalian subject are disclosed. The oligonucleotide has 8-30 bases, with at least 8 contiguous bases being complementary to the polycug or polyccug repeats in the 3′utr region of dystrophia myotonica protein kinase (dmpk) mrna in dm1 or dm2, respectively.
Sarepta Therapeutics, Inc.
03/19/15
20150079659
 Serum-free mammalian cell culture medium, and uses thereof patent thumbnailSerum-free mammalian cell culture medium, and uses thereof
The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate.
Life Technologies Corporation
03/19/15
20150079633
 Production of modified glycoproteins having multiple antennary structures patent thumbnailProduction of modified glycoproteins having multiple antennary structures
The present invention relates to lower eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar and sugar nucleotide transporters to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation.
Glycofi, Inc.
03/19/15
20150079595
 Methods and materials for detecting gene amplification patent thumbnailMethods and materials for detecting gene amplification
This document relates to methods and materials involved in detecting gene amplification in a mammal. For example, methods and materials for detecting amplification at cpm and mdm2 loci to determine the presence or absence of a malignant lipomatous neoplasm in a mammal are provided..
Mayo Foundation For Medical Education And Research
03/19/15
20150079590
 Characterization and analysis of the composition and dynamics of the mammalian riboproteome patent thumbnailCharacterization and analysis of the composition and dynamics of the mammalian riboproteome
The present invention relates to methods for identifying compounds that modulate the translation machinery and methods of diagnosing cancer related to deregulation of the translation machinery. In particular, the methods and diagnostic tests include determining an association between one or more targets and one or more components of the riboproteome and treating a subject with cancer by administering a compound that modulates the association between one or more targets and one or more components of the riboproteome..
Beth Israel Deaconess Medical Center, Inc.
03/19/15
20150079226
 Vegetable oil composition containing palm mid-fraction fat and  reducing plasma cholesterol patent thumbnailVegetable oil composition containing palm mid-fraction fat and reducing plasma cholesterol
A method and composition for reducing the cholesterolemic effect in mammals of ingesting a blended nutritional fat composition containing a palm mid-fraction (pmf) hardstock fat combined with an unsaturated vegetable oil. The composition is solid or semi-solid at 20° c.
Brandeis University
03/19/15
20150079198

Method and nutritional supplement for enhancing weight gain of a mammal


The present invention relates to a method and nutritional supplement which stimulates appetite and slows metabolism of a mammal, thereby enhancing weight gain for the mammal. The method of enhancing weight gain of the mammal comprises administering to the mammal an effective amount of at least two types of alkamide or isobutylamide compound extracted from echinacea species along with an antioxidant and optionally minerals.
03/19/15
20150079131

Prevention of inflammatory disorders in domestic non-human mammals


The present invention regards use of a bacterial superantigen for administration onto the mucous membrane of a domestic non-human mammal for the prevention of inflammatory disorder, such as allergies, autoimmune and inflammatory diseases.. .
Premune Ab
03/19/15
20150079115

Compositions and methods for preventing or relieving symptoms of infections


Food products and/or pharmaceutical preparations including (i) viral neutralizing antibodies or antibody fragments anchored to a probiotic microorganism and (ii) a carrier medium for delivering the viral neutralizing antibodies or antibody fragments anchored to probiotic microorganisms to the gut of a mammal. Also provided are methods of making food products and/or pharmaceutical preparations, which can be used to treat existing viral infections or prevent the spread or transmission of viral infection..
The Johns Hopkins University
03/19/15
20150079086

Methods for treatment of brain injury utilizing biologics


A method of using biologics to treat chronic brain injury or spasticity due to stroke, trauma and other causes. Preferred embodiments include perispinal, parenteral, transepidermal or intranasal use of tnf antagonists.
Tact Ip Llc
03/19/15
20150079069

Methods for modification of tissues


Methods for modification of mechanical properties or a shape of a mammalian tissue, excluding scar, blood clot, fat; including a step of contacting the tissue with an isolated eukaryotic endopeptidase in an amount sufficient to cause a modification of mechanical properties of the tissue or its shape, but insufficient to cause degradation of the tissue's into incohesive parts, and to the use of eukaryotic endopeptidases for use in methods for treatment of the mammalian body.. .
Elastomics Ab
03/19/15
20150079062

Method for harvesting, processing, and storage of proteins from the mammalian feto-placental unit and use of such proteins in compositions and medical treatment


The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins.
03/19/15
20150079061

Method for the harvesting, processing, and storage of proteins from the mammalian feto-placental unit and use of such proteins in compositions and medical treatment


The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins.
03/19/15
20150078996

Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders


The present invention relates to mammalian antibodies, designated 12b1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor i receptor (igf-ir), preferably human igf-ir. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein.
Pierre Fabre Medicament
03/12/15
20150074837

Transgenic mouse expressing human apo(a) and human apo(b-100) with disabled vitamin c gene produces human lp(a)


The invention discloses novel model of transgenic mammal, a method of crossbreeding transgenic mammal and the use of the transgenic mammal for assessing prevention and/or treatment methods for cardiovascular and other diseases related to lipoprotein(a). The transgenic mammal expresses human apolipoprotein (a) (apo(a)) and human apolipoprotein b-100 (apo b-100) genes and produces human lipoprotein (a), apo (a) and apo b-100 and produces no vitamin c.
03/12/15
20150074835

Transgenic mouse expressing human lipoprotein (a) with disabled vitamin c gene and its use as a disease treatment model


The invention discloses novel model of transgenic mammal, a method of crossbreeding transgenic mammal and the use of the transgenic mammal for assessing prevention and/or treatment methods for cardiovascular and other diseases related to lipoprotein(a). The transgenic mammal expresses human apolipoprotein (a) (apo(a)) and human apolipoprotein b-100 (apo b-100) genes and produces human lipoprotein (a), apo (a) and apo b-100 and produces no vitamin c.
03/12/15
20150073317

Device and applying pressure to a mammalian limb


A therapeutic pressure band for applying pressure across a muscle or muscle groups on a mammalian limb is described. The band is particularly well suited for treating “shin splints.” the band includes a plurality of straps that are connected together via a connecting material.
03/12/15
20150073045

Polycyclic compounds and methods related thereto


Or pharmaceutically acceptable salts thereof as well as pharmaceutical, nutraceutical, and botanical drug compositions and therapeutic methods related thereto. In certain embodiments, the compounds are used for the treatment of abnormal cell growth, hyperproliferative disorders, and inflammatory diseases in mammals.
03/12/15
20150073039


An embodiment of the invention provides a method of preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the protein lsd1 and/or a monoamine oxidase inhibitor. Another embodiment of the invention provides a method of preventing or treating reactivation of a virus after latency in a host, comprising administering to the host an effective amount of an inhibitor of the protein lsd1 and/or a monoamine oxidase inhibitor.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
03/12/15
20150072996

Formulations and methods for treatment of wounds and inflammatory skin conditions


The disclosure of the present application includes topically administrable compositions and methods for treating wounds and inflammatory conditions of the skin in mammals. In an exemplary embodiment, the composition includes a therapeutic amount of antihistamine selected from the group consisting of a non-sedating antihistamine, a physiologically acceptable acid of a non-sedating antihistamine, a salt of a non-sedating antihistamine, an amide of a non-sedating antihistamine, and a combination of two or more of these; a therapeutic amount of creatine; a therapeutic amount of creatinine; and emu oil product selected from the group consisting of emu oil, a biologically active fraction of emu oil, and a combination of these.
Zemtsov Enterprises, Llc
03/12/15
20150072966

Method of promoting wound healing


A method of establishing a therapeutic window of wound fluid nitric oxide (wfno) in the wound of a mammal, the method including: obtaining a wound fluid sample from a mammal; analyzing the wfno level; determining whether the wfno is at or below a lower threshold level, or is at or above an upper threshold level; wherein the lower threshold level and upper threshold level define the therapeutic window of wfno; and treating the mammal with a substance that alters the wfno level such that the therapeutic window of wfno in the wound is established.. .
3m Innovative Properties Company
03/12/15
20150072927

Methods and compositions to regulate hepcidin expression


The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of tgf-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described.
The General Hospital Corporation
03/12/15
20150072434

Methods for assessing risk of bone fracture


The invention generally relates to methods for assessing risk of bone fracture. In certain embodiments, methods of the invention involve a) conducting an assay to determine a characteristic of keratinized tissue obtained from a mammal, b) analyzing at least one bone-fracture risk factor associated with the mammal, and c) correlating results from steps (a) and (b), thereby assessing the risk of bone fracture of a bone of the mammal..
Crescent Diagnostics Limited
03/12/15
20150072428

Process for the preparation of disinfected human cell suspensions


In a process for preparing disinfected preparations from mammalian tissues, mammalian tissue is perfused at one step with an enzyme-free liquid antibiotic composition that includes at least one antibiotic and is contained in at least one perfusion buffer. In a step occurring after such one step, enzymatic antibiotic-free treatment of the tissue is carried out to obtain a single-cell suspension.
Cytonet Gmbh & Co. Kg
03/12/15
20150072422

Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc)


The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc) and/or progeny derived therefrom in vitro or in vivo comprising exposing the mpc or progeny to sdf-1 or analog thereof. The invention also relates to compositions comprising isolated mpcs or progeny derived therefrom and sdf-1 or analogues thereof.
Angioblast Systems, Inc.
03/12/15
20150072415

Medium for the protein-free and serum-free cultivation of cells


A medium is described for the protein-free and serum-free cultivation of cells, especially mammalian cells, whereby the medium contains a proportion of soy hydrolysate.. .
Baxter Innovations Gmbh
03/12/15
20150071988

Sterically stabilized carrier for aerosol therapeutics, compositions and methods for treating the respiratory tract of a mammal


This invention comprises a sterically stabilized liposome carrier encapsulating a selected drug for the aerosol delivery of the drug effectual in the treatment of a mammal, a composition containing the sterically stabilized liposome carrier and a drug effective for the treatment a mammal as an aerosol and a method of treatment using the composition. The composition provides effective treatment for the longer of a period of time at least twice as long as the drug alone or up to at least one week..
Vgsk Technologies, Inc.
03/12/15
20150071927

Anti-her2 and anti-igf-ir bi-specific antibodies and uses thereof


Disclosed are antibodies, or binding fragments thereof, that specifically bind to human her2 and human igf-ir. Also provided are nucleic acid molecules encoding the disclosed antibodies and binding fragments and vectors and host cells containing these nucleic acid molecules.
The University Of Hong Kong
03/12/15
20150071908

Compositions and methods of use of phorbol esters for the treatment of stroke


Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects..
Biosuccess Biotech Co. Ltd.
03/12/15
20150071905

High affinity sirp-alpha reagents


High affinity sirp-α reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein; and (ii) have an increased affinity for cd47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity sirpα reagent, which blocks the physiological binding interaction between sirpα and its ligand cd47..
The Board Of Trustees Of The Leland Stanford Junior University
03/12/15
20150071888

Pouch-like construct for preventing heart distension


The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and/or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties.
Universitatsklinikum Hamburg-eppendorf
03/12/15
20150071887

Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof


The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. Via injection, transplantation, or implantation) into a site of soft tissue.
University Of Pittsburgh- Of The Commonwealth System Of Higher Education
03/12/15
20150071882

Method for inducing antitumor immunity using sindbis viral vectors and tumor associated antigens


The subject application is directed to a method for treating a mammal harboring a tumor comprising identifying a tumor associated antigen (taa) expressed by the tumor and parenterally administering to the mammal a therapeutically effective amount of a sindbis viral vector carrying a gene encoding the taa to the mammal sufficient to elicit an immune response directed against the tumor, and thereby treating the tumor.. .
New York University
03/12/15
20150071874

Compositions and methods of use of phorbol esters


Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease.
Biosuccess Biotech Co. Ltd.
03/12/15
20150071853

Nucleotide and protein sequences of an antibody directed against an epitope common to human acidic and basic ferritins, monoclonal antibodies or antibody-like molecules comprising these sequences and use thereof


The present invention is directed to monoclonal, chimeric or humanized, antibodies or antibody-like molecules that recognize an epitope common to human acidic and basic isoferritins. The anti-ferritin antibodies or antibody-like molecules can be used in pharmaceutical compositions for immunotherapy or radioimmunotherapy to target various cancer cells in a mammal.
Immune Pharmaceuticals Ltd.
03/05/15
20150067897

Genetically modified non-human mammals and cells


Genetically modified mammals are described which lack the mannan binding lectin associated serine protease masp-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders.
University Of Leicester
03/05/15
20150066107

System and animal-human neural interface


Aspects of the invention include system and method for transmitting neural data extracted from an electrical signal of a non-human mammal to a human. The system includes an electrode implantable into the animal auditory nerve, brainstem, or midbrain of the non-human mammal, configured to record the electrical signal of the non-human mammal, the electrical signal being in the form of sequences of pulses or pulse trains encoding frequency information of the non-human mammal, a processing device electrically coupled with the electrode, configured to process the electrical signal and convert the processed electrical signal into a digital signal, a transmitting device electrically coupled with the processing device, configured to transmit the digital signal, and a receiving device electrically coupled with the transmitting device, configured to receive the transmitted digital signal, convert the received digital signal into a sensory output perceptible to the human, and apply the sensory output to the human..
Northwestern University
03/05/15
20150066039

Conic retraction


A conic retractor for retraction of tissue of a mammal may comprise an at least partially hollow first truncated cone (20); a second truncated cone (30), having a similar apex angle and whose opening is wider than the first truncated cone, may be configured to at least partially enter the first truncated cone and to dilate at least a distal end of the first truncated cone as it is pushed to the distal end of the cone. A third truncated cone (40) can be inserted into the second truncated cone, etc.
Nlt Spine Ltd.
03/05/15
20150065835

Impedance devices for obtaining conductance measurements within luminal organs


Impedance devices for obtaining conductance measurements within luminal organs. In at least one embodiment of an impedance device of the present disclosure, the device, comprises an elongated body and an detector positioned upon the elongated body, the detector comprising at least five electrodes and configured to obtain one or more conductance measurements generated using a first arrangement of four of the at least five electrodes and further configured to obtain one or more fluid velocity measurements using a second arrangement of four of the at least five electrodes when the elongated body is positioned within a fluid environment of a mammalian luminal organ, wherein the first arrangement is different from the second arrangement..
3dt Holdings, Llc
03/05/15
20150065790

Method for treating fecal incontinence


A method for treating fecal incontinence in a body of a mammal having a rectum formed by a rectal wall extending to an anus wherein the rectal wall includes a sphincter muscle surrounding the anus. At least one nonaqueous solution is introduced into the rectal wall in the vicinity of the anus.
Boston Scientific Scimed, Inc.
03/05/15
20150065531

Compounds for use in cancer therapy


Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell.
03/05/15
20150065528

Paralytic shellfish poison


The invention concerns a paralytic shellfish poison for the treatment of itching in a human being or another mammal.. .
Algenis Spa
03/05/15
20150065495

Substituted- 1h-benzo[d]imidazole series compounds as lysine-specific demethylase 1 (lsd1) inhibitors


The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 (“lsd1”). The present invention also relates to pharmaceutical compositions containing these compounds.
University Of Utah
03/05/15
20150065444

Method for enhancing efficacy and selectivity of cancer cell killing by dna damaging agents


The invention relates to the treatment of cancer using dna damaging agents. The invention provides methods for treating a mammal with cancer, the method comprising inhibiting in the mammal acidic residue methyltransferase (arm1) in combination with administering to the mammal a dna damaging agent.
Eastern Maine Healthcare Systems
03/05/15
20150065440

Sulfated oligosaccharide derivatives


The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.. .
Progen Pharmaceuticals Limited
03/05/15
20150065418

Neuregulin based methods and compositions for treating cardiovascular diseases


The present invention relates to compositions and methods for preventing, treating or delaying various cardiovascular diseases or disorders in mammals, particularly in humans. More particularly, the present invention provides for compositions and methods for preventing, treating or delaying various cardiovascular diseases or disorders using, inter alia, a neuregulin protein, or a functional fragment thereof, or a nucleic acid encoding a neuregulin protein, or a functional fragment thereof, or an agent that enhances production and/or function of said neuregulin..
Zensun (shanghai) Science & Technology Limited
03/05/15
20150065380

Brain somatic mutations associated to epilepsy and uses thereof


The present invention relates to epilepsy-inducing brain somatic mutations which are associated with intractable epilepsy caused by malformations of cortical development, and uses thereof. More particularly, the present invention relates to an mtor (mammalian target of rapamycin) gene having mutations in a nucleotide sequence or an mtor protein having mutations in an amino acid sequence resulting from the mutations in the nucleotide sequence.
Yonsei University, University - Industry Foundation (uif)
03/05/15
20150064794

Biorelevant compositions


This application relates to a homogeneous biorelevant composition for preparing fasted state biorelevant media having a surface tension between 25 mn/m and 50 mn/m for simulating fasted state gastric and fasted state upper small intestinal fluids of mammalian species, especially humans, dogs, etc. Comprising at least one bile salt, eg.
Phares Pharmaceutical Research N.v.
03/05/15
20150064784

Methods for culturing undifferentiated cells using sustained release compositions


Methods for culturing undifferentiated mammalian cells, such as stem and progenitor cells, are provided. The methods involve incubating the cell in the presence of a sustained release composition containing at least one growth factor, wherein the sustained release composition continuously releases the growth factor(s), and wherein the presence of the sustained level of growth factor maintains the cell in an undifferentiated state..
Regenerative Research Foundation
03/05/15
20150064771

Inducible gene expression composition for using eukaryotic pol-2 promoter-driven transcription in prokaryotes and the applications thereof


Eukaryotic protein-coding messenger rnas and non-coding micrornas are naturally transcribed by type ii rna polymerases (pol-2) but not prokaryotic rna polymerases. As a result, current eukaryotic rna and protein production is performed either using eukaryotic pol-2 promoters in hybridomas or mammalian cells or using prokaryotic promoters in bacterial cells.
Mello Biotechnology, Inc.
03/05/15
20150064744

Modified enterokinase light chain


The present invention is related to novel mammalian enterokinase analogues such as mammalian enterokinase light chain analogues and methods of making such. Also described herein is a method for cleaving proteins having an enterokinase cleavage site..
Novo Nordisk A/s
03/05/15
20150064709

Modulating gene expression with agrna and gapmers targeting antisense transcripts


Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agrna or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.. .
Board Of Regents, The University Of Texas System
03/05/15
20150064219

Methods and compositions for cancer immunotherapy using flagellin-tumor associated antigen fusion protein expressing tumor cells


Provided are methods for inducing an anti-tumor immune response by immunizing a mammal with a composition comprising a tumor cell which expresses a nlr ligand and/or tlr ligand-taa fusion protein or with an activated dc which has internalized a tumor cell which expresses an nlr- and/or tlr ligand-taa fusion protein.. .
Icahn School Of Medicine At Mount Sinai
03/05/15
20150064218

Methods and materials for treating cancer


This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided..
University Of Leeds
03/05/15
20150064208

Polyvalent chimeric ospc vaccinogen and diagnostic antigen


A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein c (ospc) types.
Virginia Commonwealth University
03/05/15
20150064192

Mammalian cell surface antigens; related reagents


Purified genes encoding a t cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided..
Merck Sharp & Dohme Corp.
03/05/15
20150064140

Methods and uses of biological tissues for various stent and other medical applications


Methods and uses of biological tissues for various stent and other medical applications. In an exemplary embodiment of a method of processing a tissue of the present disclosure, the method comprises the steps of acquiring a mammalian tissue comprising at least a portion of a pulmonary region tissue, selecting a sample of pulmonary region tissue from the at least a portion of a pulmonary region tissue, and fixing the sample of pulmonary region tissue using a fixative, resulting in a fixed sample.
Cvdevices, Llc
02/26/15
20150057519

Sensing system, gastroparesis monitoring


An expandable apparatus and method configured for inserting into a mammalian stomach and adapted for sensing the activity of the stomach wall. The apparatus comprising: a) an inflatable balloon insert-able into the stomach, when deflated; and b) one or more sensors, mounted to the external surface of the balloon.
Gema Medical Ltd.
02/26/15
20150057351

Method for treating neuropathic pain


A method for treating neuropathic pain in a mammalian subject, which comprises administering an effective amount of a fatty acid derivative, is provided.. .
Sucampo Ag
02/26/15
20150057331

Novel cellular targets for hiv infection


Methods and compositions are provided for treating hiv infection and for inhibiting hiv infection, and for identifying purinergic receptor antagonists or panx 1 hemi-channel blockers useful therefor. The invention provides a method of treating a mammalian subject having an hiv infection, or suspected of having been exposed to hiv, comprising administering to the mammalian subject an amount of (i) an antagonist of a panx 1 hemichannel, or (ii) of an inhibitor of a purinergic receptor, effective to inhibit (a) hiv fusion with a target cell, or (b) hiv replication, or (c) hiv entry into a target cell, or two or more of (a), (b) and (c)..
Albert Einstein College Of Medicine Of Yeshiva University
02/26/15
20150057320

Transthyretin ligands capable of inhibiting retinol-dependent rbp4-ttr interaction for treatment of age-related macular degeneration, stargardt disease, and other retinal disease characterized by excessive lipofuscin accumulation


A method for treating a disease characterized by excessive lipofuscin accumulation in the retina of a mammal afflicted therewith comprising administering to the mammal an effective amount of a transthyretin (ttr) ligand.. .
The Trustees Of Columbia University In The City Of New York
02/26/15
20150057278

Amido compounds as roryt modulators and uses thereof


And wherein cy1, cy2, n1, n2, r1a, r1b, r2, r3, r4, r5, and r6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease..
02/26/15
20150057220

Fused aromatic phosphonate derivatives as precursors to ptp-1b inhibitors


Fused aromatic phosphonates of structural formula i are precursors to inhibitors of protein tyrosine phosphatase-1b (ptp-1b). The compounds of the present invention are therefore useful for the treatment in a mammal of a disorder, condition, or disease responsive to inhibition of protein tyrosine phosphatase-1b, including type 2 diabetes, insulin resistance, a lipid disorder, obesity, metabolic syndrome, and cancer..
Kaneq Pharma Inc.


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