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Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications. Subscribe to the Mammal RSS feed to automatically get the update: related Mammal RSS feeds. RSS updates for this page: Mammal RSS RSS


Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive…

Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive…

Date/App# patent app List of recent Mammal-related patents
10/23/14
20140317766
 Antibody producing non-human mammals patent thumbnailAntibody producing non-human mammals
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to dna rearrangements and/or somatic hypermutations.
10/23/14
20140316484
 Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function patent thumbnailNon invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function
In one example embodiment, a neuromodulation system for inducing locomotor activity in a mammal, in cooperation with a signal generator and an electrode, delivers a signal with an overlapping high frequency pulse to a mammal. .
10/23/14
20140316122
 Hepatitis b virus vaccines patent thumbnailHepatitis b virus vaccines
This document provides methods and materials for producing immune responses against hepatitis b viruses. For example, polypeptides, nucleic acid molecules encoding such polypeptides, virus-like particles containing such polypeptides, vaccine preparations containing one or more polypeptides provided herein, vaccine preparations containing one or more nucleic acid molecules provided herein, vaccine preparations containing one or more virus-like particles provided herein, and methods for inducing immune responses against hepatitis b viruses within mammals (e.g., humans) are provided..
10/23/14
20140316005
 Compositions for improved oxidative status in companion animals patent thumbnailCompositions for improved oxidative status in companion animals
A food composition that is useful for increasing antioxidant levels in the body is provided having increased levels of sulfur-containing amino acids, such as methionine, cysteine, or mixtures thereof. Methods of using these compositions for increasing antioxidant levels in the body in mammals, especially in companion animals, are also provided..
10/23/14
20140315976
 Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells patent thumbnailDelivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy..
10/23/14
20140315966
 Isoxazole treatments for diabetes patent thumbnailIsoxazole treatments for diabetes
The present invention relates to compounds and methods for inducing synthesis and secretion of insulin from pancreatic beta cells. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo.
10/23/14
20140315955
 Stimuli responsive adhesive gel for removal of foreign particles from soft tissue patent thumbnailStimuli responsive adhesive gel for removal of foreign particles from soft tissue
The present inventions are directed to novel aqueous compositions comprising a copolymer having water-soluble units and pendant catechols, said composition adapted for use on mammalian tissue and having a lower critical solubility temperature (lcst) of less than a physiological temperature, and their use, for example, in removing foreign particles from tissue surfaces, including ocular surfaces.. .
10/23/14
20140315928
 Substituted amide compounds patent thumbnailSubstituted amide compounds
The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as ldl-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of ldl-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.. .
10/23/14
20140315917
 Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities patent thumbnailImidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities
Which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-fms (csf-1r), c-kit, and/or pdgfr kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-fms, c-kit, or pdgfr kinases..
10/23/14
20140315894
 Anti-cancer compounds targeting ral gtpases and methods of using the same patent thumbnailAnti-cancer compounds targeting ral gtpases and methods of using the same
The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a ral gtpase in the mammal. The invention also provides small molecule inhibitors of ral gtpases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same..
10/23/14
20140315870
Composition comprising a glucocorticoid and a thiazolidinedione for inducing compelte adipogenic differentiation of mammalian stem cells
The present invention relates to the provision of a composition comprising a glucocorticoid and a thiazolidinedione for inducing adipogenic differentiation, thereby successfully generating functional stem cells, from non-differentiated embryonic or adult stem cells originating from humans or other mammals, special preference being given to human mesenchymal stem cells. The preferred glucocorticoid is dexamethasone and the preferred thiazolidinedione is rosiglitazone.
10/23/14
20140315834
Compounds and compositions for use in the prevention and treatment of inflammation-related disorders, pain and fever, skin disorders, cancer and precancerous conditions thereof
The present invention provides novel compounds and pharmaceutical compositions for the prevention and/or treatment of cancer and precancerous conditions thereof, for the treatment of pain and fever, for the treatment of skin disorders, and for treating and/or preventing inflammation-related diseases and/or cardiovascular diseases. The compounds of the invention also have analgesic properties and anti-platelet properties.
10/23/14
20140315813
Use of an active biological substance in abnormal cellular and viral membrane physiologies
An active biological substance is disclosed for use in abnormal cellular and viral membrane physiologies in human and mammal organisms. The active substance has diagnostic and/or therapeutic properties and contains or consists of at least one component selected from the group of substances including: histones, covalently modified histones, histone-like polypeptides, biologically active histone sequences and histone-like polypeptides as agents for stopping the supply to solid tumours over their blood vessels, for killing cells infected by virus and for killing tumour cells with disturbed lipid asymmetry..
10/23/14
20140315807
Treatment and prevention of bone loss using resolvins
The invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolving.
10/23/14
20140315805
Locally released growth factors to mediate motor recovery after stroke
Methods of improving recovery of a mammal after an ischemic event (e.g., stroke) are provided. In various embodiments the methods involve administering a neural growth factor (e.g., bdnf) into the infarct (e.g., stroke) cavity in a biocompatible hydrogel formulation.
10/23/14
20140315748
Detection, isolation and analysis of rare cells in biological fluids
The invention provides a method for isolating or enriching a rare cell from a biological fluid of a mammal employing an antibody that binds a cell-surface antigen of the rare cell. The immobilized antibody is incubated with a sample of biological fluid that includes the rare cells and a plurality of other cells so as to form an antibody-rare cell complex.
10/23/14
20140315307
Mixed population of cells deriving from adipose tissue and methods of isolating and using the same
Adipose tissue-derived stromal cells and methods of isolating and using the same. In at least one embodiment of isolated adipose tissue-derived stromal cells of the present disclosure, the cells are isolated by performing adipose tissue resection or suction on a mammalian patient, dissecting tissue obtained from said tissue resection or suction and dissociating said tissue into a cell suspension, removing adipocytes from the cell suspension, culturing the adipocyte-depleted cell suspension in egm-2-mv media, and isolating adipose tissue-derived stromal cells secreting vascular endothelial growth factor (vegf), hepatocyte growth factor (hgf), and granulocyte-colony stimulating factor (g-csf)..
10/23/14
20140315252
Cd40l expressing mammalian cells and their use
Herein is reported a co-cultivation system for co-cultivating a pool of rabbit b-cells or single deposited rabbit b-cells wherein cells cd40l expressing cho cells are used as feeder in the presence of il-2 and il-21.. .
10/23/14
20140315242
Microfluidic chamber assembly for mastitis assay
The present invention relates to a device and method for the detection of mastitis or other disease from a body fluid of a mammal for example from cow's milk. The device and method relates to a wedge microfluidic chamber for using a minimal amount of fluid and being able to use the device to observe leukocytes in a mono-layer for the purpose of disease detection, cell counts or the like..
10/23/14
20140314841
Use of cysteamine and derivatives thereof to suppress tumor metastases
The present disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or derivatives thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein..
10/23/14
20140314838
Use of pituitary adenylate cyclase-activating polypeptide (pacap) and pacap analogs for treating contrast-induced nephropathy
Featured are methods and compositions for treating, managing, preventing, or reducing injury to the kidney of a mammal (e.g., a human) caused by one or more iodinated radiocontrast media. The methods include administering an effective amount of one or more pituitary adenylate cyclase-activating polypeptide (pacap)-like compounds, which includes native human pacap38, native human pacap27, native human vasoactive intestinal peptide (vip), their agonists, analogs, fragments, and derivatives, with activities toward one or more of the pacap/vip receptors, including all of their various isoforms.
10/23/14
20140314794
Compositions and methods for the diagnosis and treatment of tumor
The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.. .
10/23/14
20140314766
Mig-7 as a specific anticancer target
Aspects of the present invention provide novel mig-7 encoding nucleic acids and mig-7 polypeptides, recombinant dna expression systems and host cells containing same, as well as methods of inhibiting expression of the subject nucleic acid molecules, inhibiting production of the encoded proteins or polypeptides, inhibiting metastasis of a carcinoma cell in a subject (including in humans), inhibiting migration/invasion of and mimicking of normal cells by carcinoma cells in a subject, detecting the presence of a cancer cell (e.g., a migrating/invading cancer cell or carcinoma cell mimic, and tumor neovascularization) in a sample of a subject's tissue or body fluids, and inhibiting the migration/invasion of or endothelial cell mimicking by a placental cell into the blood stream or vessels of a female mammal. Particular aspects relate to novel anti-mig-7 antibodies, diagnostic and/or prognostic methods, and therapeutic methods comprising use of the inventive nucleic acids, polypeptides and antibodies or derivatives thereof..
10/23/14
20140314762
Stimulation of ovarian follicle development and oocyte maturation
Methods are provided for stimulating ovarian preantral and antral follicles in a mammal.. .
10/23/14
20140314755
Antibody producing non-human mammals
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to dna rearrangements and/or somatic hypermutations.
10/23/14
20140314735
Process for concentration of a polypeptide
The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in mammals, in particular by subcutaneous injection.. .
10/23/14
20140314714
Immunopotentiative composition
Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by pd-1, pd-l1, or pd-l2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of pd-1, pd-l1, or pd-l2 are useful for treatment of cancer or infection..
10/23/14
20140314669
Compounds for binding to the platelet specific glycoprotein iib/iiia and their use for imaging of thrombi
The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (pet) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body.
10/23/14
20140313322
Novel ovulation prediction device
This disclosure provides a stand alone electronic device to predict a likely time of ovulation based on crystal formation in a mucous body fluid sample. Optionally body temperature data may also be measured and saved on the device memory.
10/23/14
20140311055
Parapet protector
A parapet protector is disclosed which generally discourages birds, small mammals, and other nuisance animals from the rooftops of buildings. The parapet protector includes a first insulator detachably attached to a surface of a building; a first suspension eye coupled to the first insulator, the first suspension eye extending outwardly from the first insulator in a direction that is perpendicular to a plane defined by the surface of the building; a first spring that is detachably attached to a distal end of the first suspension eye; a wire that that connects the first spring to a second spring located on a second suspension eye coupled to a second insulator; and an electrical input that is configured to electrify the wire..
10/23/14
20140311026
Methods and devices for protecting plants from underground dwelling mammals
A method of protecting plants from underground dwelling mammals provides for the insertion of devices having pointed elongated members adjacent the root systems of the plants. A device for this purpose has a plurality of pointed elongated members joined by a handle section..
10/16/14
20140309714
Apparatus and method for optimized stimulation of a neurological target
A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a microelectrode-tissue interface across a range of different frequencies.
10/16/14
20140309578
Biomedical imaging and therapy using red blood cells
Certain embodiments of the present invention provide methods, of treating a skin abnormality in a mammalian subject, that involve introducing, into a vasculature of the subject, red blood cells (rbcs) that comprise a photosensitive compound; and then permitting to pass a time-period sufficient for some of the rbcs to enter a region of the subject that comprises the skin abnormality; and then exposing rbcs in the region to an amount of radiation energy sufficient to result in the photosensitive compound mediating a hyperthermic therapy, a thermal therapy, an oxygen singlet therapy, a radical molecule therapy, or a combination thereof on the skin abnormality. In some embodiments, the photosensitive compound comprises a dye and is substantially encapsulated within the rbcs.
10/16/14
20140309311
Pharmaceutical combination
A pharmaceutical combination comprising as components (a) at least one 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound, and (b) at least one nmda-antagonist, a pharmaceutical formulation and a dosage form comprising such a combination, and a method of treating pain, e.g. Inflammatory pain or neuropathic pain, in which components (a) and (b) are administered simultaneously or sequentially to a mammal, with component (a) being administered either before or after component (b), and with components (a) or (b) being administered to the mammal either via the same pathway of administration or via different pathways of administration..
10/16/14
20140309259
Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
The invention provides novel, water-soluble 2-aminoimidazoline derivatives having general formula (i) as well as some precursors of formula (i), which are very potent inducers of g2/m cell cycle arrest. In treated tumor cells, compounds of formula (i) give gene expression profile distinct from known antimitotic agents.
10/16/14
20140309257
Topoisomerase inhibitors and methods of making and use as therapeutic agents
The invention provides methods of inhibiting the growth or metastasis of cancer in a mammal by inhibiting topoiia in the mammal. The invention also provides small molecule inhibitors of topoiia useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds and methods of using the same..
10/16/14
20140309242
Method for activating ampk and the use of adenine
The present invention relates to adenine which is useful to activate amp-activated protein kinase (ampk) and the use of adenine in the prevention or treatment of conditions or disease and thereby prevent or treat conditions or diseases which can be ameliorated by ampk in a mammal.. .
10/16/14
20140309240
Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
The invention provides novel, water-soluble 2-aminoimidazoline derivatives having general formula (i) as well as some precursors of formula (i), which are very potent inducers of g2/m cell cycle arrest. In treated tumor cells, compounds of formula (i) give gene expression profile distinct from known antimitotic agents.
10/16/14
20140309224
Treatment of diseases or disorders caused by induced nfkb transcriptional activity
The invention provides a method for treating a disease or disorder in a mammal which is caused by induced nfkb transcriptional activity in cells of the mammal, the method comprising administering to the mammal a compound that specifically inhibits one or more of cdk8 and cdk19.. .
10/16/14
20140309216
Pharmaceutical compounds
Compounds of formulae ia, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including pi3k, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of formula ia for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
10/16/14
20140309203
Phytoecdysones for use in weight stabilization after a weight-loss diet
Phytoecdysones to avoid weight gain in obese mammals previously having undergone a hypocaloric weight-loss diet. The phytoecdysones are added to a food composition.
10/16/14
20140309177
Compositions and methods for the induction and tuning of gene expression
Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.. .
10/16/14
20140308734
Proteins with repetitive bacterial-ig-like (big) domains present in leptospira species
The invention relates to three isolated dna molecules that encode for proteins, bigl1, bigl2 and bigl3, in the leptospira sp bacterium which have repetitive bacterial-ig-like (big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for bigl1, bigl2 and bigl3 proteins are used for the diagnosis and prevention of infection with leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance..
10/16/14
20140308707
Method for production of factor viii
The present invention relates to methods of producing a factor viii polypeptide in mammalian cell cultures.. .
10/16/14
20140308703
Mammalian cell lines for increasing longevity and protein yield from a cell culture
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis.
10/16/14
20140308699
Yeast artificial chromosome carrying the mammalian glycosylation pathway
A yeast artificial chromosome (yac) directing the expression of one or more activities of the humanized glycosylation pathway is provided. The said yac comprises one or more expression cassettes for fusion proteins of heterologous glycosylation pathway and an er/golgi retention sequence.
10/16/14
20140308688
Human emulated response with microfluidic enhanced systems
A multiple flow-based microfluidic cell culture system that emulates mammalian physiology is provided. Tissue-mimicking cell cultures are connected by flow within a physiologically meaningful arrangement so that the pharmacokinetics of various agents to be tested in the system emulate in vivo conditions.
10/16/14
20140308675
Mutagenicity test method using mammalian cells
Provided is a test method that allows mutagenicity on a mammal including a human to be confirmed accurately and simply in a short time. Specifically, provided is a mutagenicity test method, including the steps of: (1) culturing a transformant of a mammalian cell harboring a recombinant vector including a p53 binding sequence, a minimal promoter that can function in the mammalian cell, and a reporter gene linked so that the gene can be expressed by the minimal promoter, in the presence of a test substance for a predetermined time; and (2) assessing whether or not the test substance affects an expression amount of the reporter gene in the transformant by comparing an expression amount of the reporter gene in the transformant cultured in the step (1) to an expression amount of the reporter gene in the transformant free of contact with the test substance..
10/16/14
20140308317
Polymeric compounds and methods of making and using the same
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a mycobacterium infection; killing or inhibiting the growth of a plasmodium species; inhibiting the growth of a mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.. .
10/16/14
20140308315
Apparatus, system, and method for creating immunologically enhanced spaces in-vivo
The present invention creates an immunologically protected/enhanced space in vivo in a mammal by removing the impact of soluble inhibitors of the mammal's immune system in a defined space within the body. Placing an antigen source within the defined protected space along with a monocyte-containing blood sample from the mammal being treated and a dendritic cell-inducing factor allows a dendritic-antigen presentation process to proceed to completion.
10/16/14
20140308295
Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties.
10/16/14
20140305446
Method, system, and apparatus for protecting mammalian tissue regions
Embodiments of a system and method for protecting mammalian tissue regions, the system including a removable guard cap. Other embodiments may be described and claimed..
10/09/14
20140304847
Recombination efficiency by inhibition of nhej dna repair
The present invention relates to a method for modifying a target sequence in the genome of a mammalian cell, the method comprising the step of introducing into a mammalian cell: a. One or more compounds that introduce double-strand breaks in said target sequence; b.
10/09/14
20140303540
Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject
Apparatus, system, and method are disclosed herein for controlling movement of an artificial orthopedic joint prosthesis in a mammalian subject. The apparatus, system, or method includes an orthopedic brace configured to control movement of an orthopedic joint prosthesis.
10/09/14
20140303539
Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject
Apparatus, system, and method are disclosed herein for controlling movement of an artificial orthopedic joint prosthesis in a mammalian subject. The apparatus, system, or method includes an orthopedic brace configured to control movement of an orthopedic joint prosthesis.
10/09/14
20140303538
Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject
Apparatus, system, and method are disclosed herein for controlling movement of an orthopedic joint prosthesis in a mammalian subject. The apparatus, system, or method includes an orthopedic brace configured to control movement of an orthopedic joint prosthesis.
10/09/14
20140303384
Novel phenicol antibacterials
The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these novel compounds, and methods for the preparation of these compounds.. .
10/09/14
20140303247
Membrane activated chelators and use in the prevention and treatment of parasitic infection
Provided herein are pharmaceutical compositions useful in the prevention and treatment of protozoan infections in mammals comprising administering to the subject a pharmaceutical composition comprising at least one membrane activated chelator compound which is a lipophilic diester derivative of the chelating agent 1,2-bis(2 aminophenoxy)ethane-n,n,n′,n′-tetraacetic acid, or a salt, solvate, stereoisomer, or prodrug thereof, as well as compositions which include at least one or more other anti-parasitic compound, and a pharmaceutically acceptable carrier, in an effective amount. Methods for prevention, treatment, and combination therapies are also provided..
10/09/14
20140303216
Compositions and methods for inducing disruption of blood vasculature and for reducing angiogenesis
The invention provides methods for reducing angiogenesis and/or inducing vascular disruption in a tissue in a mammalian subject in need thereof, comprising administering to the subject a therapeutic amount of thiabendazole (tbz) that is effective to reduce angiogenesis and/or induce vascular disruption in the tissue.. .
10/09/14
20140303102
Small molecule compounds that control mammal-pathogenic nematodes
The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal..
10/09/14
20140303093
Micro-utrophin polypeptides and methods
Described herein are polypeptides, polynucleotides and methods involving a μ-utrophin region or an anti-dystrophinopathic fragment thereof operationally linked to a second region effective to transduce the fusion protein into mammalian muscle cells.. .
10/09/14
20140303091
Ocular formulations of norketotifen
Ophthalmic compositions containing norketotifen and methods of making the same and the use thereof are disclosed. The methods also comprise administering to the eyes of a mammal in need thereof topical ophthalmic compositions containing norketotifen..
10/09/14
20140303076
Non-standard insulin analogues
An insulin analogue comprises a b-chain polypeptide containing a cyclohexanylalanine substitution at position b24 and optionally containing additional amino-acid substitutions at positions a8, b28, and/or b29. A proinsulin analogue or single-chain insulin analogue containing a b domain containing a cyclohexanylalanine substitution at position b24 and optionally containing additional amino-acid substitutions at positions a8, b28, and/or b29.
10/09/14
20140303073
Antisense antiviral compound and method for treating influenza viral infection
The present invention relates to antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal.
10/09/14
20140303072
Method of determining types i, ii, iii, iv or v or methicillin-resistant staphylococcus aureus (mrsa) in a biological sample
Disclosed are diagnostic methods for determining a subtype of methicillin-resistant staphylococcus aureus (mrsa) in a biological sample of a mammal. Methods include providing a biological sample of the mammal, performing a pcr analysis of the biological sample, and analyzing the pcr amplicons with respect to their sizes so as to determine for type i, type ii, type iii, type iv or type v mrsa that may be present in the biological sample.
10/09/14
20140303068
Method of treating mucus hypersecretion
The present invention relates generally to a method of reducing unwanted airway tissue mucus secretion in a mammal and to agents useful for same. More particularly, the present invention relates to a method of reducing airway tissue mucus hypersecretion in a mammal by downregulating the functional level of activin or upregulating the functional level of follistatin.
10/09/14
20140303021
Methods and devices for detecting obstructive uropathy and associated disorders
Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described..
10/09/14
20140302599
Method of co-culturing mammalian muscle cells and motoneurons
The invention provides a method of co-culturing mammalian muscle cells and mammalian motoneurons. The method comprises preparing one or more carriers coated with a covalently bonded monolayer of trimethoxysilylpropyl diethylenetriamine (deta); suspending isolated fetal mammalian skeletal muscle cells in serum-free medium according to medium composition 1; suspending isolated fetal mammalian spinal motoneurons in serum-free medium according to medium composition 1; plating the suspended muscle cells onto the one or more carriers at a predetermined density and allowing the muscle cells to attach; plating the suspended motoneurons at a predetermined density onto the one or more carriers and allowing the motoneurons to attach; covering the one or more carriers with a mixture of medium composition 1 and medium composition 2; and incubating the carriers covered in the media mixture..
10/09/14
20140302538
Markers for preeclampsia
This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided..
10/09/14
20140302537
Use of female mammal's urine for determination of fetal gender related characteristics
The present invention also provides a method of conceiving a baby of a desired gender in a female by applying to the female a pharmaceutical formulation with a specific sex hormone composition.. .
10/09/14
20140302499
Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors
Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors..
10/09/14
20140302491
Ex vivo culture, proliferation and expansion of primary tissue organoids
Culture systems and methods for long term culture of mammalian tissues are provided. Tissues include but are not limited to lung alveolar tissue, stomach tissue, pancreas tissue, bladder tissue, liver tissue, and kidney tissue.
10/09/14
20140302183
Compound, insulation, or sealant and deterrent, repellent, or barrier for rodents, mammals, insects, or other annoying pests
This invention is formula and method for dispensing, injecting, or otherwise installing a formula comprising a mixture of compounds, foams, caulks, sealants, insulations, gels or other such mediums along with poisons, barriers, repellents, or deterrents in order to facilitate sealing or insulating as well as the additional benefit of killing, blocking, deterring, repelling or otherwise hindering said rodents, mammals, insects, and/or pests.. .
10/09/14
20140302174
Combination therapy for ovarian cancer
The present invention provides a method of treating ovarian cancer in a mammal in need of such treatment comprising administering an effective amount of a combination of gemcitabine, cisplatin or carboplatin, and 5-[2-tert-butyl-5-(4-fluoro-phenyl)-1h-imidazol-4-yl]-3-(2,2-dimethyl-propyl)-3h-imidazo[4,5-b]pyridin-2-ylamine.. .
10/09/14
20140302172
Markers for susceptibility to an inhibitor of an src-family kinase
The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the src family, whereby the individual is suspected to suffer from cancer.
10/09/14
20140302134
Formulation for the controlled release of one or several substances in the digestive tract of a mammal
The present invention relates to a formulation for the controlled release of active ingredients after the passage of the ileo-cecal-valve, comprising one or more active ingredients or one or more active ingredient containing cores (w), enveloped by one or more envelopments (c), which are dissoluble or permeable above an individual defined ph value and are dissoluble or permeable below another individual defined ph value, again enveloped by an envelopment (e), which is dissoluble or permeable above still another individual defined ph value.. .
10/09/14
20140302130
Silica-matrix forming compositions, materials formed therefrom, and methods of using the same
The present invention provides compositions for encapsulation of biomaterials in a silica-matrix. The present invention also provides methods of making silica-matrix encapsulated biomaterials, and to methods of using silica-matrix encapsulated biomaterials.
10/09/14
20140302097
Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors
Compositions comprising dendritic cells pulsed with tumor lysate and at least one toll-like receptor (tlr) ligand which may be used for eliciting a specific immune response in a mammal in need thereof for treating diseases including a tumor are disclosed. Also disclose are methods of activating dendritic cells, comprising providing at least one toll-like receptor (tlr) ligand; and pulsing a dendritic cell with the at least one tlr ligand.
10/09/14
20140302088
Compositions and methods for dengue virus chimeric constructs in vaccines
Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition.
10/09/14
20140302000
Pharmaceutical compositions of lipase-containing products, in particular of pancreatin
Orally administrable pharmaceutical compositions of lipase-containing products, particularly pancreatin and pancreatin-containing products, or of enzyme products which contain at least one lipase of non-animal, especially microbial origin, which improve the lipolytic activity and particularly result in stabilization of the lipase in the acidic ph range. These oral pharmaceutical compositions contain a system which includes at least one surfactant and one co-surfactant and optionally a lipophilic phase, and are self-emulsifiable on contact with a hydrophilic and a lipophilic phase.


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