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Mammal

Mammal-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Compositions and methods for modulating an immune response
Board Of Trustee Of Michigan State University
October 12, 2017 - N°20170292127

The disclosure relates to, among other things, agents that modulate the homophilic interaction between two cracc polypeptides, methods for making such agents, and therapeutic applications in which the agents are useful. For example, the agents described herein are useful for modulating an immune response in a mammal. Also featured are screening methods for identifying additional agents capable of modulating the ...
Production cell line enhancers
Regeneron Pharmaceuticals, Inc.
October 12, 2017 - N°20170291938

The present invention relates to discovery of the ectopic expression of edem2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell, the cho cell, containing recombinant polynucleotides encoding edem2. Also disclosed is a production cell containing both an edem2...
Fgf2 truncations and mutants and uses thereof
Salk Institute For Biological Studies
October 12, 2017 - N°20170291931

The present disclosure provides fgf2 mutant proteins, such as those having an n-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Thus, the disclosed mutant fgf2 proteins can be used to treat one or more metabolic diseases. In some examples, mutant fgf2 proteins have reduced mitogenic activity. Also provided are nucleic acid molecules ...
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Temporary embolization using inverse thermosensitive polymers
Genzyme Corporation
October 12, 2017 - N°20170290948

Once aspect of the present invention relates to methods of embolizing a vascular site in a mammal comprising introducing into the vasculature of a mammal a composition comprising an inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, which composition may be injected through a small catheter, and which compsitions gel at or below body temperature. In ...
Attenuated bordetella strains
Institut National De La Santé Et De La Recherche Médicale (inserm)
October 12, 2017 - N°20170290903

A mutated bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampg gene is provided. The attenuated mutated bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a bordetella infection. Use of the attenuated bordetella strain for the manufacture of a vaccine ...
Heartworm vaccine, methods and uses thereof
Merial Inc.
October 12, 2017 - N°20170290895

The present invention encompasses a vaccine composition and method of use for treating heartworm infestation in mammals. The vaccine composition includes chimeric antigens engineered and manufactured using the genetic code (i. E., the amino acid or protein sequence) of the target sequence. After introduction of the vaccine composition containing the target antigen into the host (e. G., a canine), the ...
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Compositions and methods for dengue virus chimeric constructs in vaccines
The Government Of The United States Of America As Represented By The Secretary Of The Department
October 12, 2017 - N°20170290884

Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (den-1) virus, dengue-2 (den-2) virus, dengue-3 (den-3) or dengue-4 (...
Vascular disruption agents and uses thereof
Genentech, Inc.
October 12, 2017 - N°20170290883

Uses of apo2l/trail polypeptides and death receptor agonist antibodies to disrupt tumor associated vasculature are provided. Methods of treating cancer in mammals, kits, and articles of manufacture are also provided.
Use of pimobendan for the reduction of heart size and/or the delay of onset ...
Boehringer Ingelheim Vetmedica Gmbh
October 12, 2017 - N°20170290829

The invention relates to pimobendan for use in a method of reducing the heart size and/or delaying the onset of clinical symptoms in a patient suffering from asymptomatic (occult, preclinical) heart failure, preferably congestive heart failure, due to mitral valve disease (mvd), and/or delaying the onset of heart failure, preferably congestive heart failure, in a patient suffering from ...
Cancer treatment method
Novartis Ag
October 12, 2017 - N°20170290826

Invented is a method of treating cancer or a pre-cancerous syndrome in a mammal, including a human, in need thereof which comprises the administration of an effective amount of a non-peptide thrombopoietin (tpo) receptor agonist to such mammal, suitably a human.
Parasiticidal compositions comprising indole derivatives, methods and uses thereof
Merial, Inc.
October 12, 2017 - N°20170290803

The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
Use of gabaa receptor reinforcing agent in preparation of sedative and anesthetic medicament
Sichuan Haisco Pharmaceutical Co., Ltd.
October 12, 2017 - N°20170290781

The present disclosure provides a pharmaceutical preparation of a compound of formula (i) or a stereoisomer, pharmaceutically acceptable salt, or prodrug thereof. The present disclosure further provides a method for general anesthesia or sedation for mammals. Also provided are kits and manufactured products of the medicament and the pharmaceutical composition and a method for using the medicament and the pharmaceutical ...
Bone joining apparatus and method
Nextremity Solutions, Inc.
October 12, 2017 - N°20170290614

Provided is a bone joining device suitable for joining a first bone piece to a second bone piece. Also provided is a method of j oining a first bone piece with a second bone piece in a living mammal. The method comprises inserting the above bone joining device between the first bone piece and the second bone piece.
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Methods and materials for identifying and treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation
Mayo Foundation For Medical Education And Research
October 05, 2017 - N°20170285034

This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ascl1 and ret expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided.
Analytical methods and arrays for use in the same
Senzagen Ab
October 05, 2017 - N°20170285010

The present invention relates to a method for identifying agents capable of inducing respiratory sensitization in a mammal and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in table a(i), table a(ii) and/or table a(iii) in cells exposed to a test agent.
Gas sensor nanocomposite membranes
Meat & Livestock Australia Limited
October 05, 2017 - N°20170284956

A gas permeable, liquid impermeable membrane for use with gas sensors consists of a film forming polymer which incorporates nanoparticles selected to improve one or more of the following: permeability to gases, to selectively regulate permeability of selected gases through the membrane, to inhibit microbial growth on the membrane. A capsule shaped container consists of wall material biocompatible with a ...
Analytical methods and arrays for use in the same
Senzagen Ab
October 05, 2017 - N°20170283874

The present invention relates to an in vitro method for identifying agents capable of inducing respiratory sensitization in a mammal and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in table 1a, table 1b and/or table 1c in mutz-3 cells exposed to a test agent.
Methods and kits for detection of 5-hydroxymethylcytosine
Oslo Universitetssykehus Hf
October 05, 2017 - N°20170283863

The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmc). In some embodiments, the present invention relates to methods and kits for detection of 5hmc in nucleic acid (e. G., dna, rna). In some embodiments, the present invention relates to detection of 5hmc in genomic dna, e. G., mammalian genomic dna.
Mammalian chimeric complementation
Salk Institute For Biological Studies
October 05, 2017 - N°20170283777

Disclosed herein are chimeric mammals, such as a chimeric mammal comprising cells derived from at least a first mammal and a second mammal, wherein the cells from the first mammal comprise a genetic modification at one or more loci and the cells from the second mammal form at least one organ or tissue, wherein the first and second mammals are ...
Reprogramming cells
The Scripps Research Institute
October 05, 2017 - N°20170283776

The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3′-phosphoinositide-dependent kinase-1 (pdk1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
Downregulation of sine/alu retrotransposon transcription to induce or restore proliferative capacity and/or pluripotency ...
Buck Institute For Research On Aging
October 05, 2017 - N°20170283770

In certain embodiments methods are provided for inducing and/or restoring and/or maintaining a non-senescent phenotype, or aspects thereof (e. G., proliferative capacity and/or pluripotency) in a mammalian cell. The methods typically involve reducing the level or activity of sine/alu retrotransposon transcripts in the cell in an amount sufficient to induce or restore proliferative capacity and/or ...
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