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Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications. Subscribe to the Mammal RSS feed to automatically get the update: related Mammal RSS feeds. RSS updates for this page: Mammal RSS RSS


Date/App# patent app List of recent Mammal-related patents
02/26/15
20150057519
 Sensing system,  gastroparesis monitoring patent thumbnailnew patent Sensing system, gastroparesis monitoring
An expandable apparatus and method configured for inserting into a mammalian stomach and adapted for sensing the activity of the stomach wall. The apparatus comprising: a) an inflatable balloon insert-able into the stomach, when deflated; and b) one or more sensors, mounted to the external surface of the balloon.
Gema Medical Ltd.
02/26/15
20150057351
 Method for treating neuropathic pain patent thumbnailnew patent Method for treating neuropathic pain
A method for treating neuropathic pain in a mammalian subject, which comprises administering an effective amount of a fatty acid derivative, is provided.. .
Sucampo Ag
02/26/15
20150057331
 Novel cellular targets for hiv infection patent thumbnailnew patent Novel cellular targets for hiv infection
Methods and compositions are provided for treating hiv infection and for inhibiting hiv infection, and for identifying purinergic receptor antagonists or panx 1 hemi-channel blockers useful therefor. The invention provides a method of treating a mammalian subject having an hiv infection, or suspected of having been exposed to hiv, comprising administering to the mammalian subject an amount of (i) an antagonist of a panx 1 hemichannel, or (ii) of an inhibitor of a purinergic receptor, effective to inhibit (a) hiv fusion with a target cell, or (b) hiv replication, or (c) hiv entry into a target cell, or two or more of (a), (b) and (c)..
Albert Einstein College Of Medicine Of Yeshiva University
02/26/15
20150057320
 Transthyretin ligands capable of inhibiting retinol-dependent rbp4-ttr interaction for treatment of age-related macular degeneration, stargardt disease, and other retinal disease characterized by excessive lipofuscin accumulation patent thumbnailnew patent Transthyretin ligands capable of inhibiting retinol-dependent rbp4-ttr interaction for treatment of age-related macular degeneration, stargardt disease, and other retinal disease characterized by excessive lipofuscin accumulation
A method for treating a disease characterized by excessive lipofuscin accumulation in the retina of a mammal afflicted therewith comprising administering to the mammal an effective amount of a transthyretin (ttr) ligand.. .
The Trustees Of Columbia University In The City Of New York
02/26/15
20150057278
 Amido compounds as roryt modulators and uses thereof patent thumbnailnew patent Amido compounds as roryt modulators and uses thereof
And wherein cy1, cy2, n1, n2, r1a, r1b, r2, r3, r4, r5, and r6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease..
02/26/15
20150057220
 Fused aromatic phosphonate derivatives as precursors to ptp-1b inhibitors patent thumbnailnew patent Fused aromatic phosphonate derivatives as precursors to ptp-1b inhibitors
Fused aromatic phosphonates of structural formula i are precursors to inhibitors of protein tyrosine phosphatase-1b (ptp-1b). The compounds of the present invention are therefore useful for the treatment in a mammal of a disorder, condition, or disease responsive to inhibition of protein tyrosine phosphatase-1b, including type 2 diabetes, insulin resistance, a lipid disorder, obesity, metabolic syndrome, and cancer..
Kaneq Pharma Inc.
02/26/15
20150056697
 Pluripotent stem cells and  stimulating and extracting non-embryonic pluripotent stem cells from mammal blood and using reconstituted pluripotent stem cells to treat diseases including chronic obstructive pulmonary disease patent thumbnailnew patent Pluripotent stem cells and stimulating and extracting non-embryonic pluripotent stem cells from mammal blood and using reconstituted pluripotent stem cells to treat diseases including chronic obstructive pulmonary disease
Stimulating tissue resident pluripotent stem cells in a manner that the respective subject (e.g., human) acts as its own sterile bioreactor for in vivo stem cell proliferation thus eliminating the need to isolate, cultivate, maintain, proliferate and release stem cells ex vivo. The stimulation mobilizes excess pluripotent stem cells into the peripheral vasculature where the pluripotent stem cells can either migrate to damaged tissues and/or be harvested by simple venipuncture, thus eliminating potential morbidity and mortality elicited from harvesting tissue from solid tissue sites.
Royal Medical Group, Pllc
02/26/15
20150056647
 Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells patent thumbnailnew patent Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells
The invention relates to methods for differentiating progenitor cells into insulin producing pancreatic islet cells and compositions and methods for using such cells.. .
Vesta Therapeutics Inc.
02/26/15
20150056538
 Device for protecting crops using hologram of natural enemy eyes and  fabricating the same patent thumbnailnew patent Device for protecting crops using hologram of natural enemy eyes and fabricating the same
Disclosed are a device for protecting crops from wildlife, comprising an optical base film on both sides of which fluorescent holograms of natural enemies with both eyes and optionally claws or talons are laser printed while a composition containing a phosphorescent material and a repellent is applied to both eyes, and optionally to the claws or talons, and a method for fabricating the same. Oils and extracts from herbs are used selectively as ingredients in the repellent depending on repelling targets, that is, mammals, rodents and birds.
Bio Defense
02/26/15
20150056309
 Composition and  the safe and effective inhibition of pancreatic lipase in mammals patent thumbnailnew patent Composition and the safe and effective inhibition of pancreatic lipase in mammals
Provided are a composition and method for the safe and effective inhibition of pancreatic lipase in humans and other mammals. Provided is a composition which contains extracts of one or more of coleus forskohlii, salacia reticulata, and sesamum indicum, and which is administered orally to humans and other mammals in a nutritionally or pharmacologically effective amount.
Bio Actives Japan Corporation
02/26/15
20150056251
new patent

Aav-directed persistent expression of an anti-nicotine antibody gene for smoking cessation


The invention is directed to an adeno-associated virus (aav) vector which comprises a nucleic acid sequence encoding an antibody that binds to nicotine or a nicotine analog, or an antigen-binding fragment thereof. The invention also is directed to a composition comprising the aav vector and methods of using the aav vector to induce an immune response against nicotine in a mammal..
Cornell University
02/26/15
20150056230
new patent

Equine encephalitis virus vaccines and methods of using thereof


Disclosed herein are nucleotide sequences which encode a plurality of structural proteins, except the capsid, of an equine encephalitis virus, wherein the nucleotide sequence is codon-optimized for mammalian expression. The nucleotide sequences are codon-optimized for expression in humans.
02/26/15
20150056174
new patent

Self-cleaving ribozymes and uses thereof


In certain embodiments, the disclosure relates to compositions and methods relating to a ribozyme-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to schistosome self-cleaving rna mutant motifs..
Children's Medical Center Corporation
02/19/15
20150052626

Compositions and methods for fluorescent genetic bar-coding in mammalian cells for enhanced multiplexing capabilities in flow cytometry


The invention provides cells or populations of cells, including non-human animals or non-human mammals having these cells, where the cells or populations of cells are stably tagged, uniquely identified and genetically barcoded by one or more detectable, e.g., fluorescent, proteins; and methods of making and using them. In alternative embodiments, the invention provides methods for tagging, uniquely identifying or genetically barcoding a cell, a population of cells, or a culture of cells by stably transferring, transfecting, transducing, infecting or implanting one or more nucleic acids encoding readable or detectable, e.g., fluorescent, moieties into the cells.
San Diego State University (sdsu) Foundation, Dba San Diego State University (sdsu) Research Founda
02/19/15
20150052624

Genetically modified rat models for pain


This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of gene(s) or gene product(s) resulting in altered nervous system function. In one aspect, the altered function results in pain in the mammal.
Transposagen Biopharmaceuticals, Inc.
02/19/15
20150051455

Smart joint implant sensors


A prosthesis for implantation into a mammalian body, the device comprising: (a) a prosthesis for implantation into a mammalian body that includes a sensor array comprising a plurality of sensors mounted to the prosthesis; and (b) an electronics structure for receiving signals from the sensor array and wirelessly transmitting representative signals to a remote receiver, where the plurality of sensors are operative to sense pressure, applied to the prosthesis by another object, in at least two axes generally perpendicular to one another.. .
Zimmer, Inc.
02/19/15
20150051381

Combinatorial dna library for producing modified n-glycans in lower eukaryotes


The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities such as those involved in glycosylation to intracellular compartments in a eukaryotic host cell.
Glycofi, Inc.
02/19/15
20150051380

Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds


The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.. .
Genentech, Inc.
02/19/15
20150051284

Lipid-lowering antidiabetic agent


A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.. .
Thetis Pharmaceuticals Llc
02/19/15
20150051242

Rafamycin analogs and methods for making same


A semi-synthetic rapamycin analog with a triazole moiety or a pharmaceutically acceptable salt or prodrug thereof, is a broad-spectrum cytostatic agent and a mtor inhibitor, and is useful in the treatment of various cancers, or tumors in organs such as kidney, liver, breast, head and neck, lung, prostate, and restenosis in coronary arteries, peripheral arteries, and arteries in the brain, immune and autoimmune diseases. Also disclosed are fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosois, post-transplant tissue rejection, and immune and autoimmune disease in a mammal.
Zhejiang Zylox Medical Device Co., Ltd.
02/19/15
20150051192

Blocking of cue-induced drug reinstatement


A method of preventing drug use relapse by administering an effective amount of an α3β4 nicotinic antagonist to a mammal after an initial period of drug use, and preventing a relapse of drug use. A method of preventing drug use relapse due to cue inducement by administering an effective amount of an α3β4 nicotinic antagonist to a mammal after an initial period of drug use, and preventing a relapse of drug use during cue inducement.
Albany Medical College
02/19/15
20150051178

Estriol therapy for autoimmune and neurodegenerative diseases and disorders


The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, including post-partum auto immune diseases. Most preferably the invention uses estrogens, estranges, estriol or estrogen receptor active agents to prevent or ameliorate clinical symptoms of these th1-mediated (cell-mediated) autoimmune diseases known to either have an initial onset following the birth of a child or which are exacerbated in patients in the post-partum period..
The Regents Of The University Of California
02/19/15
20150051148

Hydrogel system comprising spatially separated bioactive polypeptides


The present invention provides a multi-compartment hydrogel, and a sulfated polysaccharide and at least two bioactive polypeptides capable of binding said sulfated polysaccharide, for use in repair or regeneration of a damaged tissue in a mammal. Also provided is a method for constructing the multi-compartment hydrogel.
Ben-gurion University Of The Negev Research And Development Authority
02/19/15
20150051136

Human soluble receptor for advanced glycation end products (srage), methods of preparing human srage, and treatment methods using srage


The present disclosure provides a method for recombinant production of human srage in mammalian cells, as well as a human srage having a mammalian post-translational modification and compositions thereof. The present disclosure also provides a method of treating a vascular disease, injury, or inflammation in a mammal by administering to a mammal with a vascular disease, injury, or inflammation a composition comprising human srage having a mammalian post-translational modification, thereby treating the vascular disease, injury, or inflammation in the mammal..
The United States Of America,as Represented By The Secretary, Department Of Health And Human Service
02/19/15
20150050641

Method for the enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates


A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic acid staining dye that stains dna (micronuclei) in erythrocyte populations. Because the fluorescent emission spectra of the first and second fluorescent labeled antibodies do not substantially overlap with one another or with the emission spectra of the nucleic acid staining dye, upon excitation of the labels and dye it is possible to detect the fluorescent emission and light scatter produced by the erythrocyte populations and platelets, and count the number of cells from one or more erythrocyte populations in said sample.
Litron Laboratories, Ltd.
02/19/15
20150050328

Methods for treating eye disorders


The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one sirna which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified sirna compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye..
Quark Pharmaceuticals, Inc.
02/19/15
20150050262

Oligosaccharides comprising an aminooxy group and conjugates thereof


The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates.
Genzyme Corporation
02/19/15
20150050260

Pyrroloquinoline quinone based compositions and uses


The present invention provides pharmaceutical and dietary compositions in which pyrroloquinoline quinone (pqq) and its derivatives are combined with other biologically active compounds to produce a synergistic beneficial effect beyond the effect produced by pqq or its derivatives alone. The present invention also provides methods for providing various beneficial effects which comprise administering these compositions to a mammalian subject..
4141 Holdings, Llc
02/19/15
20150050259

Nutraceutical modulators of stem cell activity


The present invention relates to a nutraceutical formulation useful for increasing the concentrations of circulating stem cells in a mammal. Disclosed are compositions of matter for increasing the concentrations of circulating stem cells in the blood, consisting of a mixture of natural compounds comprising: ashwagandha, milk thistle, vitamin d3, fucoidan, and garcinia indica.
Creative Medical Health Inc.
02/19/15
20150050252

Pluripotent stem cells and stimulating and extracting non-embryonic pluripotent stem cells from mammal blood and using reconstituted pluripotent stem cells to treat diseases including chronic obstructive pulmonary disease


Stimulating tissue resident pluripotent stem cells in a manner that the respective subject (e.g., human) acts as its own sterile bioreactor for in vivo stem cell proliferation thus eliminating the need to isolate, cultivate, maintain, proliferate and release stem cells ex vivo. The stimulation mobilizes excess pluripotent stem cells into the peripheral vasculature where the pluripotent stem cells can either migrate to damaged tissues and/or be harvested by simple venipuncture, thus eliminating potential morbidity and mortality elicited from harvesting tissue from solid tissue sites.
Royal Medical Group, Pllc
02/19/15
20150050250

Cell therapy technology to deliver radio-protective peptides


A method of reducing a symptom of radiation exposure in a subject is provided. The method includes a step of introducing mammalian cells into the subject, the mammalian cells having been treated ex vivo to insert therein a polynucleotide encoding polypeptide that is protective against radiation.
University Of Southern California
02/19/15
20150050245

Methods and delivery system for beneficial additive and subtractive biological agents to promote balanced mammalian gastrointestinal flora


This invention relates to controlled release formulations of probiotic bacteria and bacteriophages, including combined formulations of probiotic bacteria and bacteriophages. The formulations contain a hydrophilic agent, an electrolytic agent and a polysaccharide and may be in tablet form for oral delivery to the intestinal system.
Tntgamble, Inc.
02/19/15
20150050243

Delivery of packaged rna to mammalian cells


Described herein are compositions relating to alphavirus-based virus-like particles (vlps) and methods for making and using the described vlps. The described compositions include vlps and vectors and cells used to produce the vlps.
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
02/19/15
20150050239

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
02/19/15
20150050233

Compositions containing inclusion complexes


The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent.
California Institute Of Technology
02/19/15
20150049083

Comparative analysis of anatomical items


A computer-implemented medical visualization method includes identifying a three-dimensional model of an anatomical item of a particular mammal; displaying a moving animation of the three-dimensional model, the moving animation created from multiple frames from imaging of the anatomical item over a short time period to capture movement of the anatomical item; displaying one or more non-moving views of the three-dimensional model while the moving animation is being displayed; and in response to receiving inputs from a user, changing the displayed moving animation and the one or more non-moving views automatically in coordination with each other.. .
02/19/15
20150049081

Computer visualization of anatomical items


A computer-implemented medical visualization method includes identifying a three-dimensional model of an anatomical item of a particular mammal; automatically identifying an open path in three-dimensional space through the anatomical item; fitting a smooth curve to the open path; and displaying the anatomical item and a visual representation of the smooth curve to a user on a three-dimensional imaging system.. .
02/12/15
20150047064

Inhibiting gene expression with dsrna


The present invention relates to the specific inhibition of gene expression in mammals by bringing the target gene into contact with double stranded rna (dsrna).. .
Cancer Research Technology Limited
02/12/15
20150045610

Method of modifying spermatogenesis, spermiogenesis and/or fertility in mammals


Methods and compositions for modifying fertility and/or spermatogenesis or spermiogenesis in a male mammalian subject involve administering to the subject or contacting the subject's testis cells, germ cells or sperm with a composition that modifies the activation, nucleic acid expression, protein expression, signaling or activity of one or more t1r3 receptors or an intermediate in the signaling pathways thereof in the subject's testis cells or germ cells. In another embodiment, the method further involves administering to the subject or contacting the subject's testis cells, germ cells or sperm with a composition that modifies the activation, nucleic acid expression, protein expression, signaling or activity of g-α-gustducin, or an intermediate in the signaling pathways thereof.
Monell Chemical Senses Center
02/12/15
20150045508

Immobilised biological entities


There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.. .
02/12/15
20150045374

2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids


The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an hiv infection, treating the proliferation of the hiv virus, treating aids or delaying the onset of aids or arc symptoms in a mammal using compounds disclosed herein..
Gilead Sciences, Inc.
02/12/15
20150045350

Method for noribogaine treatment in patients on methadone


A short treatment with noribogaine shows promise for treating drug dependency. Many opioid addicts are treated with methadone.
Demerx, Inc.
02/12/15
20150044768

Methods and compositions for production of recombinant protein in hbx-expressing mammalian cells


The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding hepatitis b x protein and the heterologous protein, by growing mammalian host cells selected from the group consistng of hkb11, cho, bhk21, c2c12, and hek293 cells, by growing mammalian host cells in non-adherent suspension culture, or by growing mammalian host cells which contain nucleic acid providing exogenous x-box binding protein, xbp1s. The conditions should be such that hbx, exogenous xbp1s if present, and the heterologous protein are expressed by the mammalian cells.
Bayer Healthcare Llc
02/12/15
20150044747

Methods for increasing production of 3-methyl-2-butenol using fusion proteins


The invention relates, in part, to nucleic acid constructs, genetically modified host cells and methods employing such constructs and host cells to increase the production of 3-methyl-2-butenol from ipp. Thus, in some aspects, the invention provides a genetically modified host cell transformed with a nucleic acid construct encoding a fusion protein comprising a phosphatase capable of catalyzing the dephosphorylation of dimethylallyl diphosphate (dmapp) linked to an ipp isomerase capable of converting ipp to dmapp, wherein the nucleic acid construct is operably linked to a promoter.
The Regents Of The University Of California
02/12/15
20150044707

At-home blood pregnancy test kit


Disclosed is an at-home blood pregnancy test kit that can identify the presence of hcg in a blood sample to detect pregnancy in female mammals. The present kit includes a housing having a sample strip that is in fluid communication with a sample pad for holding a blood sample, a test pad, and a conjugate pad.
02/12/15
20150044259

Scaffold for enhanced neural tissue regeneration


This application discloses a scaffold for promoting the growth of a nerve in a mammal while minimizing clumping, which comprises a support structure having an elongate opening formed therein and configured for placement around a damaged region of a nerve and a physiologically acceptable matrix composition in said opening, said matrix composition comprising a poly-d lysine (pdl) and a peptidoglycan, and nerve growth factor (ngf).. .
02/12/15
20150044249

Polyvalent chimeric ospc vaccinogen and diagnostic antigen


A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein c (ospc) types.
Virginia Commonwealth University
02/12/15
20150044243

Mucosal immunization to prevent prion infection


Vaccines against prion disease eliciting a humoral immune response when administered mucosally are described. The vaccines comprise a prion protein, a prion protein fragment, or a non-amyloidogenic prion protein homolog and an adjuvant suitable for inducing a humoral immune response after mucosal administration.
New York University
02/12/15
20150044241

Contraceptive vaccines for mammals


The invention provides a contraceptive vaccine for a female recipient of a target species of mammals including a composition of at least one of a plurality of granulosa cells and a plurality of ovarian stromal cells in combination with an adjuvant; wherein the cells are grown from a tissue sample of the cells obtained from at least one female donor of the target species which is not the same individual as the female recipient. The invention also provides a method of producing the contraceptive vaccine as well as a method of treating a female recipient with the contraceptive vaccine to prevent pregnancy..
Contra Vaccine Limited
02/12/15
20150044199

Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis


The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of loxl2 expression and activity, such as shrna targeting loxl2..
Technion Research & Development Foundation Ltd.
02/12/15
20150044188

Antiviral methods and compositions comprising probiotic bacterial molecules


Molecules secreted or derived from probiotic bacteria are provided for use in compositions and methods for the treatment and/or prevention of infection by pathogenic viruses. The isolated secreted molecules can also be used in nutritional or medical food products which provide probiotics to the gastrointestinal tract of a mammal..
02/12/15
20150044185

Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof


The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. Via injection, transplantation, or implantation) into a site of non-soft tissue (e.g.
University Of Pittsburgh-of The Commonwealth System Of Higher Education
02/12/15
20150044170

Expression of virus entry inhibitors and recombinant aav therefor


The present invention relates generally to the use of recombinant adeno-associated viruses (raav) for gene delivery and more specifically to the use of raav to deliver genes encoding human immunodeficiency virus entry inhibitors to target cells in mammals.. .
Nationwide Children's Hospital, Inc.
02/12/15
20150044166

Compositions and methods for treatment of exercise-induced pulmonary hemorrhage or nasopharyngeal cicatrix


Methods, compositions, and medical device systems relating to treating exercise-induced pulmonary hemorrhage (eiph) and nasopharyngeal cicatrix (nc) in a mammal. For example, one method comprises administering through inhalation a composition comprising a physiologically acceptable carrier and an effective amount of each of one or more stem cell derived factors.
Riddle Institute
02/12/15
20150044164

Methods of treating autoimmune diseases


Novel methods for treating patients with autoimmune diseases are disclosed. The methods of the invention include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent tgf-β and/or another agent that promotes expansion of regulatory t cells.
Genzyme Corporation
02/12/15
20150044139

Method of treatment or prevention of hair loss or for the enhancement of hair growth


The present application relates to use of a midkine family protein for growing hair on a mammal, or in the manufacture of a medicament for growing hair on a mammal, especially for treatment or prevention of different forms of alopecia.. .
Advangen International Pty Ltd
02/05/15
20150040250

Animal models and therapeutic molecules


The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.. .
Kymab Limited
02/05/15
20150038985

Enhanced follicular extraction punch and method


Provided herein is an apparatus and method useful for surgical removal of mammalian tissue at specific depths and specific angles.. .
02/05/15
20150038886

Delivery of audio and tactile stimulation therapy for animals and humans


A system for providing a therapeutic treatment to a mammal for a selected mammalian condition includes a wearable member configured for use about an upper torso of a mammal and an energy module configured to generate energy waves in an energy range particularly configured to provide a stimulation that is therapeutically effective treatment for the selected mammalian condition. The energy module is adapted to be supported by the wearable member about the upper torso of the mammal.
Nuro Health, Llc
02/05/15
20150038778

Itih5 as a diagnostic marker of uterine development and functional defects


The invention relates to the use of itih5 as a biomarker of endometrium receptivity to embryo implantation. Also provided are methods and kits for using this biomarker for detecting the receptivity state of the endometrium of a mammal to embryo implantation, for diagnosing infertility in a female mammal, for the early diagnosis of pregnancy, for detecting the window of embryo implantation in the endometrium of a female mammal, for in vitrofertilization of a female mammal, and for diagnosing endometriosis..
Cewntree Hospitalier Universitaire Pontchaillou
02/05/15
20150038570

Compositions and products containing s-equol, and methods for their making


A composition for use in making commercial food and skin products comprising 5-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of s-equol and r-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments.
Australian Health & Nutrition Association Limited
02/05/15
20150038560

Methods and compositions for treating neuropathies


Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons.
Washington University
02/05/15
20150038556

Cftr mrna compositions and related methods and uses


Materials, formulations, production methods, and methods for delivery of cftr mrna for induction of cftr expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis..
Ethris Gmbh
02/05/15
20150038507

Antiprotozoal compounds


The invention is directed to a compound of formula i, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula i, a method of treatment of a disorder or condition that may be treated by administration of the compound, the method comprising administering to a mammal in need of such treatment a compound of formula i as described above, and a method of treatment of a disorder or condition selected from the group consisting of human african trypanosomiasis (hat), chagas disease, leishmaniasis and malaria, the method comprising administering to a mammal, including a human, in need of such treatment a compound of formula i as described above.. .
02/05/15
20150038466

Pain relief compounds


The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.. .
Universite D'auvergne Clermont I
02/05/15
20150038453

Preparation for use of aspartate and vitamin b12 or biotin for regulating ketone bodies


It has been found that high amounts of aspartate equivalents in combination with vitamin b12 and/or biotin, especially in relative absence of glutamate equivalents, improve the metabolism of ketobodies and/or lactate in a mammal's body, especially in diseased or traumatic conditions. As a result, levels of ketobodies and lactate can be decreased and unphysicologically high acidity normalised.
N.v. Nutricia
02/05/15
20150038440

Dihydrofuran azetidine derivatives as antiparasitic agents


This invention recites dihydrofuran substituted azetidine derivatives of formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in mammals and birds. The substituents a, r1a, r1b, r1c, r2, r3, r4, r6, and n are as described herein..
Zoetis Llc
02/05/15
20150038359

Method of predicting outcome in cancer patients


A method of prognosis for a mammal with cancer is provided. The method includes the steps of determining in a biological sample obtained from the mammal the expression level of each biomarker of the group dstn, tdrd3, rgs4, myo1e, rpl3, hypothetical flj13769, anp32c, mc2r, dkfzp434l092, gpr27, hps and lcp1; comparing the expression level of each biomarker with the expression level of a housekeeping gene; and rendering a prognosis for the mammal of a greater than 50% survival for an extended period of time when the expression level of dstn, tdrd3, rgs4, myo1e, rpl3(1), rpl3(2), rpl3(3), hypothetical flj13769 and anp32c is decreased in comparison to the expression of the housekeeping gene, and the expression level of mc2r, dkfzp434l092, gpr27, hps5 and lcp1 is increased in comparison to the expression of the housekeeping gene..
Mcmaster University
02/05/15
20150037884

Tissue scaffold


A tissue engineered construct made totally or in part from biocompatible materials and mammalian cells and/or cell products is provided. These constructs are useful in regenerating complex tissues such as bone, ligament and tendon, which may fabricated into medical devices suitable for use in the treatment of injuries and maladies such as rotator cuff injuries, periodontal disease and hernia..
Synthasome, Inc.
02/05/15
20150037882

Scalable process for therapeutic cell concentration and residual clearance


Apparatus and corresponding method for concentration and washing of live mammalian cells, for preparation of human cell therapy products. Optimized parameters for a temperature regulated, completely closed, fully disposable and scalable counterflow centrifugation separation system having integrated disposables designed for both the input cells and output cells are provided..
Lonza Walkersville, Inc
02/05/15
20150037871

Therapeutic nuclease compositions and methods


Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.. .
University Of Washington
02/05/15
20150037841

Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells


The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein..
Bayer Pharmaceuticals Corporation
02/05/15
20150037821

Methods of identifying hit-antibodies and pf4 antagonists and cell lines for use therein


Methods and cells or cell lines for identifying antibodies or fragments thereof that activate heparin-induced thrombocytopenia (hit) are described. The methods comprise contacting a hematopoietic cell or cell line that comprises, in operative association, the platelet receptor fcyriia under the control of a suitable promoter, and a reporter construct comprising a reporter gene under the control of a promoter and transcription factor, which transcription factor is regulated downstream of the signaling cascade of activated fcyriia, with a test sample from a mammalian subject; a platelet factor 4 (pf4), a wild-type or variant of pf4 or a fragment thereof; and heparin; and detecting or measuring the level of reporter gene expression..
The University Of Birmingham
02/05/15
20150037794

Marker for diagnosing forelimb-girdle muscular anomaly in mammal individual, and detection method using same


The present invention uses an isolated polynucleotide having a part or whole of gfra1 gene, mutant gfra1 protein, and mrna encoding the mutant gfra1 protein, each of which includes a loss-of-function mutation of gfra1, as markers for diagnosing an animal as affected by forelimb-girdle muscular anomaly or as a carrier of forelimb-girdle muscular anomaly. In addition, an isolated polynucleotide comprising one or more selected from the group consisting of mok2630, mok2637, snp b, and snp d can be used as markers for diagnosing whether a bovine animal is affected by forelimb-girdle muscular anomaly or whether a bovine animal is a carrier of forelimb-girdle muscular anomaly..
National University Corporation Okayama University
02/05/15
20150037774

Medical training kits and methods to simulate treatment of uncontrolled hemorrhage


Medical training kits and methods include a simulated liquid blood which simulates mammalian whole blood and a simulated hemostatic component. The simulated liquid blood includes a gellable component, and a simulated hemostatic component includes a gelling agent.
Luna Innovations Incorporated
02/05/15
20150037404

Methods for joint lubrication and cartilage wear prevention making use of glycerophospholipids


A method for lubricating a joint of a mammal by administering into a cavity of the joint a composition of liposomes that are multilamellar vesicles (mlv) dispersed in a fluid medium, the liposomes having a mean diameter of between about 0.8 μm to about 10 μm and including membranes of at least one glycerophospholipid (gpl) having two c12-c16 hydrocarbon chains which are the same or different. These membranes have a phase transition temperature in which solid ordered (so) to liquid disordered (ld) phase transition occurs, the phase transition temperature being at a temperature of about 20° c.
Yissum Research Development Company Of The Hebrew University Of Jerusalem
02/05/15
20150037403

Use of mir-23a-3p and/or mir-27a-3p mimics as therapeutic agents for inhibition of neuronal apoptosis following brain injury


The present invention relates to a method for treating a brain injury due to a traumatic event, disease or ischemic attack in a mammal subject, wherein the method comprises administering to the mammal subject an effective amount of mir-23a-3p and/or mir-27a-3p mimics to reduce activation of puma, noxa and bax therby causing a subsequent reduction in neuronal apoptosis.. .
University Of Maryland, Baltimore
02/05/15
20150037401

Sirna compositions and methods for inhibiting gene expression in tumor initiating cells of breast cancer


Disclosed are methods and compositions for sirna-mediated therapy of mammalian diseases. In particular, compositions and methods are disclosed for treatment of therapy-resistant human breast cancers.
02/05/15
20150037366

Method for treating inflammation


A method for reducing or alleviating inflammation in a subject includes administering to the subject a therapeutically effective amount of: (a) ac-tmp-1 or a biologically active fragment or variant of ac-tmp-1; (b) ac-tmp-2 or a biologically active fragment or variant of ac-tmp-2; or (c) a combination of (a) and (b), to thereby reduce or alleviate inflammation in the subject. A method for preventing or treating asthma or inflammatory bowel disease in a subject includes administering to the subject a therapeutically effective amount of: (a) ac-tmp-1 or a biologically active fragment or variant of ac-tmp-1; (b) ac-tmp-2 or a biologically active fragment or variant of ac-tmp-2; or (c) a combination of (a) and (b), to thereby prevent or treat asthma or inflammatory bowel disease in the subject.
James Cook University
02/05/15
20150037361

Compositions and methods to treat the bihormonal disorder in diabetes


The described invention provides methods and compositions for treating diabetes and hyperglycemia in a mammal comprising administering to the mammal a therapeutic amount of a glucagon depleting compound. Also provided are methods and compositions for eliciting a bihormonal response in a mammal comprising administering to the mammal a therapeutic amount of a glucagon depleting compound.
02/05/15
20150037297

Sickled erythrocytes and progenitors target cytotoxics to tumors


The present invention provides therapeutic mammalian cells which synthesize and express ss hemoglobin and a tumoricidal transgene. They are produced by transduction of ss erythroid progenitors/erythroblasts using viral vectors comprising a tumoricidal transgene operatively linked to the coding region of ss β-globin promoter/enhancer.
02/05/15
20150037294

Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1


The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a nell1 protein or a nell1 nucleic acid molecule..
Ut-battelle, Llc
02/05/15
20150037292

Stromal stem cells


Stromal stem cells are prospectively isolated from human bone marrow then expanded into clonal populations and cultured and used, the isolation being on the basis of expression of a cell surface marker, wherein the cell surface marker binds an antibody and wherein said antibody cross reacts with a cell surface marker found on mouse stromal stem cells or rat stromal stem cells, and optionally also on a cell of at least one other mammalian species selected from mouse, rat, horse, rabbit and pig cells. Useful stromal stem cell populations are positive for sdc2..
Orbsen Therapeutics Limited
02/05/15
20150037289

Activating adipose-derived stem cells for transplantation


A method of preparing a stem cell preparation is provided. The method includes steps of collecting adipose tissue from a mammal, contacting that adipose tissue with an enzyme preparation to digest fat and connective tissue and preserve stem cells and collecting those stem cells.
Medivet Pty Ltd.
02/05/15
20150037280

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Calitor Sciences, Llc
02/05/15
20150037251

Mammalian homologues of flower, their use in cancer diagnostics, prevention and treatment


The invention relates inhibiting nucleic acids directed at mammalian homologues of the drosophila fwe gene (flower) and to antibodies against the respective proteins, and their use in diagnosing, preventing and treating cancer.. .
Centro Nacional De Investigaciones Oncologicas


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