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Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications. Subscribe to the Mammal RSS feed to automatically get the update: related Mammal RSS feeds. RSS updates for this page: Mammal RSS RSS


Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject

Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject

Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject

Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject

Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject

Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject

Date/App# patent app List of recent Mammal-related patents
10/09/14
20140304847
 Recombination efficiency by inhibition of nhej dna repair patent thumbnailRecombination efficiency by inhibition of nhej dna repair
The present invention relates to a method for modifying a target sequence in the genome of a mammalian cell, the method comprising the step of introducing into a mammalian cell: a. One or more compounds that introduce double-strand breaks in said target sequence; b.
10/09/14
20140303540
 Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject patent thumbnailApparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject
Apparatus, system, and method are disclosed herein for controlling movement of an artificial orthopedic joint prosthesis in a mammalian subject. The apparatus, system, or method includes an orthopedic brace configured to control movement of an orthopedic joint prosthesis.
10/09/14
20140303539
 Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject patent thumbnailApparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject
Apparatus, system, and method are disclosed herein for controlling movement of an artificial orthopedic joint prosthesis in a mammalian subject. The apparatus, system, or method includes an orthopedic brace configured to control movement of an orthopedic joint prosthesis.
10/09/14
20140303538
 Apparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject patent thumbnailApparatus, system, and method for controlling movement of an orthopedic joint prosthesis in a mammalian subject
Apparatus, system, and method are disclosed herein for controlling movement of an orthopedic joint prosthesis in a mammalian subject. The apparatus, system, or method includes an orthopedic brace configured to control movement of an orthopedic joint prosthesis.
10/09/14
20140303384
 Novel phenicol antibacterials patent thumbnailNovel phenicol antibacterials
The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these novel compounds, and methods for the preparation of these compounds.. .
10/09/14
20140303247
 Membrane activated chelators and use in the prevention and treatment of parasitic infection patent thumbnailMembrane activated chelators and use in the prevention and treatment of parasitic infection
Provided herein are pharmaceutical compositions useful in the prevention and treatment of protozoan infections in mammals comprising administering to the subject a pharmaceutical composition comprising at least one membrane activated chelator compound which is a lipophilic diester derivative of the chelating agent 1,2-bis(2 aminophenoxy)ethane-n,n,n′,n′-tetraacetic acid, or a salt, solvate, stereoisomer, or prodrug thereof, as well as compositions which include at least one or more other anti-parasitic compound, and a pharmaceutically acceptable carrier, in an effective amount. Methods for prevention, treatment, and combination therapies are also provided..
10/09/14
20140303216
 Compositions and methods for inducing disruption of blood vasculature and for reducing angiogenesis patent thumbnailCompositions and methods for inducing disruption of blood vasculature and for reducing angiogenesis
The invention provides methods for reducing angiogenesis and/or inducing vascular disruption in a tissue in a mammalian subject in need thereof, comprising administering to the subject a therapeutic amount of thiabendazole (tbz) that is effective to reduce angiogenesis and/or induce vascular disruption in the tissue.. .
10/09/14
20140303102
 Small molecule compounds that control mammal-pathogenic nematodes patent thumbnailSmall molecule compounds that control mammal-pathogenic nematodes
The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal..
10/09/14
20140303093
 Micro-utrophin polypeptides and methods patent thumbnailMicro-utrophin polypeptides and methods
Described herein are polypeptides, polynucleotides and methods involving a μ-utrophin region or an anti-dystrophinopathic fragment thereof operationally linked to a second region effective to transduce the fusion protein into mammalian muscle cells.. .
10/09/14
20140303091
 Ocular formulations of norketotifen patent thumbnailOcular formulations of norketotifen
Ophthalmic compositions containing norketotifen and methods of making the same and the use thereof are disclosed. The methods also comprise administering to the eyes of a mammal in need thereof topical ophthalmic compositions containing norketotifen..
10/09/14
20140303076
Non-standard insulin analogues
An insulin analogue comprises a b-chain polypeptide containing a cyclohexanylalanine substitution at position b24 and optionally containing additional amino-acid substitutions at positions a8, b28, and/or b29. A proinsulin analogue or single-chain insulin analogue containing a b domain containing a cyclohexanylalanine substitution at position b24 and optionally containing additional amino-acid substitutions at positions a8, b28, and/or b29.
10/09/14
20140303073
Antisense antiviral compound and method for treating influenza viral infection
The present invention relates to antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal.
10/09/14
20140303072
Method of determining types i, ii, iii, iv or v or methicillin-resistant staphylococcus aureus (mrsa) in a biological sample
Disclosed are diagnostic methods for determining a subtype of methicillin-resistant staphylococcus aureus (mrsa) in a biological sample of a mammal. Methods include providing a biological sample of the mammal, performing a pcr analysis of the biological sample, and analyzing the pcr amplicons with respect to their sizes so as to determine for type i, type ii, type iii, type iv or type v mrsa that may be present in the biological sample.
10/09/14
20140303068
Method of treating mucus hypersecretion
The present invention relates generally to a method of reducing unwanted airway tissue mucus secretion in a mammal and to agents useful for same. More particularly, the present invention relates to a method of reducing airway tissue mucus hypersecretion in a mammal by downregulating the functional level of activin or upregulating the functional level of follistatin.
10/09/14
20140303021
Methods and devices for detecting obstructive uropathy and associated disorders
Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described..
10/09/14
20140302599
Method of co-culturing mammalian muscle cells and motoneurons
The invention provides a method of co-culturing mammalian muscle cells and mammalian motoneurons. The method comprises preparing one or more carriers coated with a covalently bonded monolayer of trimethoxysilylpropyl diethylenetriamine (deta); suspending isolated fetal mammalian skeletal muscle cells in serum-free medium according to medium composition 1; suspending isolated fetal mammalian spinal motoneurons in serum-free medium according to medium composition 1; plating the suspended muscle cells onto the one or more carriers at a predetermined density and allowing the muscle cells to attach; plating the suspended motoneurons at a predetermined density onto the one or more carriers and allowing the motoneurons to attach; covering the one or more carriers with a mixture of medium composition 1 and medium composition 2; and incubating the carriers covered in the media mixture..
10/09/14
20140302538
Markers for preeclampsia
This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided..
10/09/14
20140302537
Use of female mammal's urine for determination of fetal gender related characteristics
The present invention also provides a method of conceiving a baby of a desired gender in a female by applying to the female a pharmaceutical formulation with a specific sex hormone composition.. .
10/09/14
20140302499
Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors
Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors..
10/09/14
20140302491
Ex vivo culture, proliferation and expansion of primary tissue organoids
Culture systems and methods for long term culture of mammalian tissues are provided. Tissues include but are not limited to lung alveolar tissue, stomach tissue, pancreas tissue, bladder tissue, liver tissue, and kidney tissue.
10/09/14
20140302183
Compound, insulation, or sealant and deterrent, repellent, or barrier for rodents, mammals, insects, or other annoying pests
This invention is formula and method for dispensing, injecting, or otherwise installing a formula comprising a mixture of compounds, foams, caulks, sealants, insulations, gels or other such mediums along with poisons, barriers, repellents, or deterrents in order to facilitate sealing or insulating as well as the additional benefit of killing, blocking, deterring, repelling or otherwise hindering said rodents, mammals, insects, and/or pests.. .
10/09/14
20140302174
Combination therapy for ovarian cancer
The present invention provides a method of treating ovarian cancer in a mammal in need of such treatment comprising administering an effective amount of a combination of gemcitabine, cisplatin or carboplatin, and 5-[2-tert-butyl-5-(4-fluoro-phenyl)-1h-imidazol-4-yl]-3-(2,2-dimethyl-propyl)-3h-imidazo[4,5-b]pyridin-2-ylamine.. .
10/09/14
20140302172
Markers for susceptibility to an inhibitor of an src-family kinase
The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the src family, whereby the individual is suspected to suffer from cancer.
10/09/14
20140302134
Formulation for the controlled release of one or several substances in the digestive tract of a mammal
The present invention relates to a formulation for the controlled release of active ingredients after the passage of the ileo-cecal-valve, comprising one or more active ingredients or one or more active ingredient containing cores (w), enveloped by one or more envelopments (c), which are dissoluble or permeable above an individual defined ph value and are dissoluble or permeable below another individual defined ph value, again enveloped by an envelopment (e), which is dissoluble or permeable above still another individual defined ph value.. .
10/09/14
20140302130
Silica-matrix forming compositions, materials formed therefrom, and methods of using the same
The present invention provides compositions for encapsulation of biomaterials in a silica-matrix. The present invention also provides methods of making silica-matrix encapsulated biomaterials, and to methods of using silica-matrix encapsulated biomaterials.
10/09/14
20140302097
Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors
Compositions comprising dendritic cells pulsed with tumor lysate and at least one toll-like receptor (tlr) ligand which may be used for eliciting a specific immune response in a mammal in need thereof for treating diseases including a tumor are disclosed. Also disclose are methods of activating dendritic cells, comprising providing at least one toll-like receptor (tlr) ligand; and pulsing a dendritic cell with the at least one tlr ligand.
10/09/14
20140302088
Compositions and methods for dengue virus chimeric constructs in vaccines
Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition.
10/09/14
20140302000
Pharmaceutical compositions of lipase-containing products, in particular of pancreatin
Orally administrable pharmaceutical compositions of lipase-containing products, particularly pancreatin and pancreatin-containing products, or of enzyme products which contain at least one lipase of non-animal, especially microbial origin, which improve the lipolytic activity and particularly result in stabilization of the lipase in the acidic ph range. These oral pharmaceutical compositions contain a system which includes at least one surfactant and one co-surfactant and optionally a lipophilic phase, and are self-emulsifiable on contact with a hydrophilic and a lipophilic phase.
10/09/14
20140301989
Methods for increasing the potency and efficacy of stem cells
The disclosure of the present application provides methods and kits for the increase in efficacy of adipose stromal cells. In at least one embodiment, the present disclosure includes disclosure of a method of cell-based therapy, the method comprising the steps of exposing at least one mammalian stem cell expressing mesenchymal-epithelial transition factor (c-met) to a compound operable to phosphorylate c-met and administering the at least one mammalian stem cell to a patient..
10/09/14
20140301982
Complement antagonists and uses thereof
Disclosed are antagonists designed to inhibit or block expression of a mammalian complement such as complement component 6 (c6). The invention has a wide range of uses including use in the preparation of a medicament for the enhancement of nerve regeneration following acute or chronic nerve damage in a mammal.
10/09/14
20140301971
Medical device comprising boswellic acid
A medical composition and devices made from the composition for the delivery of extracts obtained from boswellia genus, similar compounds synthetically derived, and in particular derivatives of triterpenes is disclosed. The medical device may be implantable, or alternatively a device which contacts the interior of a mammalian body.
10/09/14
20140301958
Transoral methods and compositions for wrinkle reduction and cosmetic lip and facial augmentation
The purpose of this patent is to teach the methods of application and compositions of cosmetic and therapeutic products for reducing wrinkle appearance and augmenting certain compartments of the facial integument of a mammal, especially a human. These methods and compositions utilize the hypodermis-targeted release from bioadhesive oral films, pastes or patches applied to oral mucosa or teeth for the purpose of improving the appearance or health of the lips and facial skin..
10/02/14
20140298505
Protein having nuclease activity, fusion proteins and uses thereof
The present invention relates to a nucleic acid molecule encoding (i) a polypeptide having the activity of an endonuclease, which is (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of seq id no: 1; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of seq id no: 2; (c) a nucleic acid molecule encoding an endonuclease, the amino acid sequence of which is at least 70% identical to the amino acid sequence of seq id no: 1; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 50% identical to the nucleotide sequence of seq id no: 2; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (e) wherein t is replaced by u; (ii) a fragment of the polypeptide of (i) having the activity of an endonuclease. Also, the present invention relates to a vector comprising the nucleic acid molecule and a protein encoded by said nucleic acid molecule.
10/02/14
20140298494
Animal model of autism
Some aspects of this invention provide a non-human animal model of autism. Some aspects of this invention provide a non-human animal model for diseases or disorders associated with an overexpression or a copy number variance of a ube3a gene.
10/02/14
20140296843
Apparatus and method for treating cancer cells and bacteria in mammals including humans
Bacteria, cancer cells, fungus and other harmful cells located beneath the surface of a mammal body can be effectively destroyed by passing an electrical current through the area to be treated. Electrodes are positioned on either side of the area to be treated, for example, gums, fingers, arms, legs, feet and torso, and an electric current is caused to flow between the electrodes and through the area to be treated.
10/02/14
20140296836
Gold-in-silicon nanoassembly for thermal therapy and methods of use
The present invention provides methods and compositions for the nanotechnology-based therapy of one or more mammalian diseases. Disclosed are gold-in-porous silicon nanoassemblies that are effective in the targeted and localized treatment of one or more human hyperproliferative disorders, including, for example, cancer of the breast.
10/02/14
20140296833
Intrauterine system for use in medical treatment
An intrauterine system is disclosed for use in the treatment of dysfunctional uterine bleeding; menorraghia; dysmenorrhoea; endometriosis; uterine fibroids; climacteric complaints; osteoporosis; and urogenital atrophy. The system is formed by a frame defining an interior space for receipt of a deposit of a therapeutically effective dose of a biologically active compound.
10/02/14
20140296752
Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry
This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tscs) to the mammal at a frequency and intensity that induces the desired locomotor activity..
10/02/14
20140296567
3-hydroxyanthranilic acid (3-haa) therapy for prevention and treatment of hyperlipidemia and its cardiovasular complications
The present invention relates to the use of a tryptophan metabolite, 3-hydroxyanthranilic acid (3-haa) or a functional analogue thereof, for prophylactic and/or therapeutic treatment of mammals, in special humans, against hyperlipidemia and its cardiovascular complications, i.e. Atheroma formation, myocardial infarction and heart failure, ischemic stroke and transient ischemic attacks, renal impairment, aortic aneurysms and critical limb ischemia caused by atherosclerosis..
10/02/14
20140296324
Vectors harboring toxic genes, methods and uses therefor
The present disclosure describes nucleic acids, and viruses comprising such nucleic acids, for growing a toxic gene in an insect cell. These nucleic acids comprise a sequence encoding a toxic polypeptide, and an intron that interrupts the sequence, whereby the intron is spliced in mammalian cells but not in insect cells.
10/02/14
20140296252
1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities
Which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-fms (csf-1r), c-kit, and/or pdgfr kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-fms, c-kit, or pdgfr kinases..
10/02/14
20140296179
Nutritional composition comprising immunoglobulins and oligosaccharides
The present invention provides a method and composition for the treatment and/or prevention of infection, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and immunoglobulin from the milk or colostrum of hyperimmunized cows.. .
10/02/14
20140296162
Whey protein composition with a reduced astringency
The invention relates to a sterilized liquid or semi-solid acid enteral composition comprising per 100 ml 9 to 20 g of non-hydrolysed globular proteins, fat and at least 100 mg of divalent metal cations and having a ph ranging between 3 and 5. The invention further relates to a method for preparing a composition according to the invention, comprising a step wherein at least the non-hydrolysed globular proteins are subjected to a direct steam injection (dsi) at specific holding values, such as a holding temperature of 100 to 140° c.
10/02/14
20140296130
Novel inhibitors of mammalian tight junction opening
The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. Peptide tight junction antagonists.
10/02/14
20140295521
Method for reducing the immune response to a biologically active protein
A new use of a molecule comprising at least one moiety which is a biologically active protein and at least one moiety capable of binding to a serum albumin of a mammal is provided, for preparation of a medicament which elicits no or a reduced immune response upon administration to the mammal, as compared to the immune response elicited upon administration to the mammal of the biologically active protein per se. Also provided is a method of reducing or eliminating the immune response elicited upon administration of a biologically active protein to a human or non-human mammal, which comprises coupling the polypeptide to at least one moiety capable of binding to a serum albumin of the mammal..
10/02/14
20140295501
Novel method to load a mammalian artificial chromosome with multiple genes
The invention provides for a system for uploading genes of interest into an artificial chromosome expression system (ace) that has been engineered to include multiple sites for site-specific, recombination directed integration, whereby a second or further gene of interest can be loaded onto the ace by a targeting vector, through the acceptor recombination site(s) on said ace.. .
10/02/14
20140295497
Vectors and host cells comprising a modified sv40 promoter for protein expression
The present disclosure is directed to expression vectors, comprising a weakened sv40 promoter, and recombinant mammalian cells capable of producing high levels of a polypeptide of interest, methods of generating and using such recombinant mammalian cells.. .
10/02/14
20140295426
Methods for diagnosing cancer by characterization of tumor cells associated with pleural or serous fluids
A method for diagnosing or differentially diagnosing a cancer characterized by the presence of cancer cells in the pleural fluid of a mammalian subject, the method comprising contacting a sample of pleural fluid of the subject with colloidal magnetic particles coupled to a ligand which binds to a determinant on a cancer cell, but does not bind above a baseline threshold to other cellular and non-cellular components in pleural fluid; subjecting the pleural fluid-magnetic particle mixture to a magnetic field to produce a cell fraction enriched in ligand coupled-magnetic particle-bound cancer cells, if present in the pleural fluid; and analyzing the enriched fraction for the number of cancer cells in the pleural fluid. In certain aspects, this method involves preparing the pleural fluids for the above-noted method steps by, e.g., dilution of unprocessed pleural fluid.
10/02/14
20140295409
Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences
The present invention provides an isolated mammalian negative strand rna virus, metapneumovirus (mpv), within the sub-family pneumoviridae, of the family paramyxoviridae. The invention also provides isolated mammalian negative strand rna viruses identifiable as phylogenetically corresponding or relating to the genus metapneumovirus and components thereof.
10/02/14
20140295009
Composition and method for boosting immunological response
A method for reducing inflammation at a site of injury in a mammal. A composition with an effective amount of pomegranate extract is administered to a mammal.
10/02/14
20140294954
Misuse preventative, controlled release formulation
Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a first layer and a second layer. The core comprises a superabsorbent material (for example, polycarbophil), and a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed within the core.
10/02/14
20140294951
Oral formulations mimetic of roux-en-y gastric bypass actions on the ileal brake; compositions, methods of treatment, diagnostics and systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hyperlipidemia, and t2d
The invention provides pharmaceutical compositions, methods for the treatment of and related diagnostics and computer-implementable systems that relate to, the treatment of a variety of metabolic syndromes, including hyperlipidemia, weight gain, obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states. In an additional aspect of the invention, compositions and methods of treatment are calibrated to the ileal brake response to surgical intervention e.g.
10/02/14
20140294900
Flagellin related polypeptides and uses thereof
The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptsis is described.. .
10/02/14
20140294895
Expression of protective antigens in transgenic chloroplasts and the production of improved vaccines
Vaccines for conferring immunity in mammals to infective pathogens are provided, as well as vectors and methods for plastid transformation of plants to produce protective antigens and vaccines for oral delivery. The invention further provides transformed plastids having the ability to survive selection in both the light and the dark, at different developmental stages by using genes coding for two different enzymes capable of detoxifying the same selectable marker, driven by regulatory signals that are functional in proplastids as well as in mature chloroplasts.
10/02/14
20140294889
Use of the pacap as a molecular adjuvant for vaccines
The present invention relates to the use of the pituitary adenylate cyclase activating peptide (pacap) as a molecular adjuvant for vaccines. Among other applications, these vaccines may be used in the protection against infectious agents such as viruses, bacteria and ectoparasites affecting mammals, birds and aquatic organisms.
10/02/14
20140294798
Rbap48 transgenic mice for drug discovery in age-related memory decline
Described is a transgenic mouse with two transgenes, each of which transgene comprises a dna sequence encoding a dominant negative form of rbap48 protein, wherein the expression of the dominant negative form of rbap48 is spatially restricted to the forebrain by a cam kinase iia promoter and wherein the expression of the dominant negative form of rbap48 is controlled by tetracycline-controlled transcriptional activation. Also provided are methods for evaluating in the transgenic mouse the potential therapeutic effect of an agent for slowing, inhibiting or preventing age-related memory decline in a mammalian subject..
10/02/14
20140290123
Multi-layer trap system for disease prevention
Techniques for disease prevention using insect traps are provided. A refillable, attachable and wearable trap system with ability to attract, ensnare, immobilize, or kill a tick or other targeted walking arachnid or insect present on the surface of a host mammal may include a housing with a cavity, such that the housing contains a refillable immobilizing layer or substrate that includes a chemical-based arachnid or insect attractant.
09/25/14
20140289878
Method for producing model animal, and model animal
A method for producing a model animal which has a desired lifetime, and in which a predetermined biological reaction can be induced, and a model animal are provided. The present invention produces a first individual in which a gene of interest is heterozygously deficient using a first es cell from a non-human mammalian animal.
09/25/14
20140288632
Graft device with adhered fiber matrix
A graft device including a tubular member and a fiber matrix surrounding the tubular member for a mammalian patient is disclosed. At least a portion of the fiber matrix is adhered to the tubular member.
09/25/14
20140288582
Implant localization device
An implantable medical device for providing structural support to tissue is described wherein the implant adheres to tissue without the benefit of suture, surgical adhesive and the like. The adherent or localization means is a hemostat or protein polymerizing materials such as oxidized cellulose, alpha cellulose, polyanhydroglucuronic acid and the like.
09/25/14
20140288571
Method and system for destroying of undesirable formations in mammalian body
A method and a system for destruction of an undesirable formation in a mammalian body are described. The invention is based on inserting a probe into mammalian body; said probe is electrically connectable to a control unit and upon bringing the probe in physical contact with the formation supplying pulses of energy from the control unit to the probe in order to destroy the formation.
09/25/14
20140288569
Non-lithotripsic kidney-stone therapy
One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy.
09/25/14
20140288381
Three-dimensional adhesive device having a microelectronic system embedded therein
A three-dimensional adhesive device to be attached to the body surface of a mammal including a microelectronic sensing system. The system includes (a) a three-dimensional adhesive body made of a pressure sensitive adhesive having an upper surface and a bottom surface; (b) a microelectronic system embedded in the body of the pressure sensitive adhesive; (c) one or more cover layer(s) attached to the upper surface; and (d) optionally a release liner releasably attached to the bottom surface.
09/25/14
20140288276
Humanized anti-ccr2 antibodies and methods of use therefor
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) cc-chemokine receptor 2 (ccr2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian ccr2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods..
09/25/14
20140288100
Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders
Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal.
09/25/14
20140288047
Benzoxazepin pi3k inhibitor compounds and methods of use
Benzoxazepin compounds of formula i, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: z1 is cr1 or n; z2 is cr2 or n; z3 is cr3 or n; z4 is cr4 or n; and b is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of pi3k, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of formula i for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
09/25/14
20140288028
Novel pharmaceutical salts and polymorphs of a factor xa inhibitor
The present invention provides for salts comprising a compound of formula i and an acid that has activity against mammalian factor xa. The present invention is also directed to methods of making the compound of formula i..
09/25/14
20140288005
Compound for treatment of alzheimer's disease and familial dementia
An isolated protein is provided for use in treatment of a condition selected from the group consisting of alzheimer's disease, familial danish dementia and familial british dementia in a mammal, including man. The isolated protein is selected from the group consisting of proteins comprising an amino acid sequence having at least 70% identity to residues 90-236 of bri2 from human; and proteins comprising an amino acid sequence having at least 70% identity to any one of the brichos domains of bri2 from human, chimpanzee, bovine, pig, mouse and rat..
09/25/14
20140288003
Inhibition of collagen synthesis
Therapies and compositions for reducing collagen synthesis in mammalian cells and tissues wherein the targets are scleraxis, scleraxis-binding sites, receptor-regulated smads, and/or binding sites for receptor-regulated smads whereby synergistic interactions between scleraxis proteins and receptor-regulated smads are reduced, inhibited, interfered with, stopped, and/or prevented thereby reducing, inhibiting and/or interfering with the activation of collagen 1α2 promoter thereby inhibiting collagen production in mammalian cells and tissues. Alternatively, the therapies and compositions may reduce, inhibit, interfere with, stop, and/or prevent binding of the collagen 1α2 promoter to dna thereby inhibiting expression of the collagen 1α2 gene in mammalian cells and tissues..


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This listing is a sample listing of patent applications related to Mammal for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mammal with additional patents listed. Browse our RSS directory or Search for other possible listings.
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