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Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications. Subscribe to the Mammal RSS feed to automatically get the update: related Mammal RSS feeds. RSS updates for this page: Mammal RSS RSS


Date/App# patent app List of recent Mammal-related patents
09/11/14
20140257482
 Tissue scaffolds derived from forestomach extracellular matrix patent thumbnailTissue scaffolds derived from forestomach extracellular matrix
The present invention pertains to the development of extracellular matrix (ecm) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction.
09/11/14
20140256808
 Use of ketogenic compounds for treatment of age-associated memory impairment patent thumbnailUse of ketogenic compounds for treatment of age-associated memory impairment
This invention relates to the field of therapeutic agents for the treatment of age-associated memory impairment (aami). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in aami.
09/11/14
20140256802
 Dual-aav vector-based systems and methods for delivering oversized genes to mammalian cells patent thumbnailDual-aav vector-based systems and methods for delivering oversized genes to mammalian cells
Disclosed are materials and methods for treating diseases of the mammalian eye, and in particular, usher syndrome 1b (ush1b). The invention provides aav-based, dual-vector systems that facilitate the expression of full-length proteins whose coding sequences exceed that of the polynucleotide packaging capacity of an individual aav vector.
09/11/14
20140256801
 Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain patent thumbnailPeripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain
The invention provides a method of treating spinal cord injury pain or peripheral neuropathic pain in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence encoding a glutamic acid decarboxylase (gad) protein in an amount effective to treat spinal cord injury pain or peripheral neuropathic pain.. .
09/11/14
20140256620
 Methods for reducing cd36 expression patent thumbnailMethods for reducing cd36 expression
The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1..
09/11/14
20140256586
 Methods and compositions for diagnosis of colorectal cancer patent thumbnailMethods and compositions for diagnosis of colorectal cancer
Methods and compositions are provided for diagnosing colorectal cancer in a mammalian subject, preferably in a serum or plasma sample of a human subject. The methods and compositions enable the detection or measurement in the sample or from a protein level profile generated from the sample, the protein level of one or more specified biomarkers.
09/11/14
20140256051
 Decarboxylation dosimetry patent thumbnailDecarboxylation dosimetry
Methods and apparatuses of the present disclosure provide accurate and precise radiation dosimetry based on decarboxylation of a reactant upon exposure to ionizing radiation. The decarboxylation reaction yields carbon dioxide and stable end products, which can be detected and measured, and correlated to determine an amount of radiation exposure.
09/11/14
20140256043
 Small chemical compound which promotes induction of differentiation of stem cells into insulin-producing cells and method for inducing differentiation of stem cells into insulin-producing cells using said small chemical compound patent thumbnailSmall chemical compound which promotes induction of differentiation of stem cells into insulin-producing cells and method for inducing differentiation of stem cells into insulin-producing cells using said small chemical compound
A purpose of the present invention is to provide a small chemical compound which especially promotes induction of the differentiation of es cells into insulin-producing cells. Another purpose of the present invention is to provide: a method for inducing the differentiation of es cells into insulin-producing cells using the compound; and an agent for promoting induction of the differentiation into insulin-producing cells.
09/11/14
20140256027
 Perfusion culture method and perfusion culture device for organ or tissue patent thumbnailPerfusion culture method and perfusion culture device for organ or tissue
Disclosed are a perfusion culture method and a perfusion culture device whereby a perfusate can be delivered to all parts of an organ or tissue so that the organ or tissue can be preserved while sufficiently maintaining the function thereof. Specifically disclosed is a method for perfusion culture of an organ or tissue removed from a mammal, said organ or tissue having been removed together with a second organ or tissue connected to the aforesaid organ or tissue in vivo, which comprises a step for fixing said second organ or tissue so as to hang the aforesaid organ or tissue and a step for perfusing blood vessels in the aforesaid organ or tissue with a perfusate..
09/11/14
20140255993
 Mammalian cell culture patent thumbnailMammalian cell culture
The invention provides a method for culturing mammalian cells. The method provides greater control over cell growth to achieve high product titer cell cultures by changing the temperature of the cell culture and/or by starving the cells in their asparagine supply..
09/11/14
20140255542
Composition and method for reducing blood glucose levels
The present invention relates to a composition and method for reducing blood glucose levels in a mammal, such as canines and humans. The composition includes bran, cinnamon, yeast, gelatin, and optionally, wheat germ oil, octacosanol, and/or flavor.
09/11/14
20140255506
Osteoinductive demineralized cancellous bone
An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone.
09/11/14
20140255504
Enhancement of the efficacy of therapeutic proteins
A formulation for administration of at least one therapeutic mammalian protein to a mammal or a protein selected from the group, and for enhancing the absorption, distribution and release of the at least one therapeutic mammalian protein in or on the mammal, comprising at least one therapeutic mammalian protein in a micro-emulsion comprising a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. A method for effective delivery of at least one therapeutic mammalian protein to a mammal and for enhancing the therapeutic efficacy of such at least one therapeutic mammalian protein, comprising the step of administering the at least one therapeutic mammalian protein to the mammal in such a formulation..
09/11/14
20140255465
Process for the preparation of a non-corrosive base solution and methods of using same
The present invention provides novel methods of making a non-corrosive base solution for use as an alkalinity increasing agent and/or antioxidant. The present invention further provides novel compositions and methods which can be used to provide relief from acidosis, acidemia, and disorders related to or complicated by acidosis or excessive free radical or other reactive oxygen species production in mammalian subjects..
09/11/14
20140255462
Xenotransplant compositions and methods of stroke therapy
Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal.. .
09/11/14
20140255455
Methods for the production of a cosmetic composition comprising leukolectin and uses thereof
The present invention relates to cosmetic compositions comprising polypeptides obtained or obtainable from salmonidae hatching fluid, methods of producing said compositions and their use in various cosmetic applications to the skin, particularly for improving the cosmetic appearance of skin of a mammalian animal.. .
09/11/14
20140255402
Method of treating leukemia in a mammal
The present invention provides a method of treating a leukemia in a mammal comprising sequentially administering to the mammal an amount of an immunotoxin and an amount of a chemotherapeutic agent effective to treat the leukemia.. .
09/11/14
20140255395
Complement inhibition for improved nerve regeneration
The present invention relates to methods and medicaments used for treating conditions that require axonal regeneration, e.g. In mammals affected by injury or disease of the central or peripheral nervous system.
09/11/14
20140255394
Method of treating colorectal cancer
The present invention relates to the use of certain platinum compounds including [ptcl2(cis-1,4-diaminocyclohexane)], or combinations of these compounds with a variety of other agents for treating and/or preventing the progression of colorectal cancer in mammals. In particular, the invention provides methods of treating and/or preventing oxaliplatin-refractory colorectal cancer in mammals..
09/11/14
20140255334
Bone graft materials containing calcium phosphate and povidone-iodine
Described herein are materials and methods for reducing the risk of infection at a surgical site performed to restore or repair bone in an animal. Bone graft materials for implantation into a mammal are contemplated containing an antimicrobial agent.
09/11/14
20140255300
Fap-activated proteasome inhibitors for treating solid tumors
Disclosed are proteasome inhibitors, fibroblast activation protein (fap)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in treating cancer or other cell proliferative diseases.
09/04/14
20140249466
System and method for neuromodulation of body temperature regulation system
A system for controlling and modulating a mammalian's body temperature and thermoregulation system includes: a. A display monitor; b.
09/04/14
20140249396
Il-1 receptor antagonist-coated electrode and uses thereof
The present invention provides an electrode designed for implantation into the central nervous system (cns) of a mammal, wherein said electrode is substantially coated with interleukin-1 receptor antagonist (il-1ra) or a coating composition comprising it, and the il-1ra actively inhibits scarring on or around the surface of the electrode when implanted into the cns. The electrode of the invention may be used for brain recording and/or stimulation, and can thus be used for treatment of a brain dysfunction, a brain disease or disorder, or a brain injury, as well as for brain computer interface, brain machine interface, or electrotherapy..
09/04/14
20140249378
Systems, methods and kits for measuring cough and respiratory rate using an accelerometer
The disclosures is directed to cough detectors, methods and kits. Cough detectors can include, for example, a housing adaptable to engage an abdomen or thorax of a mammal; a first sensor comprising an agm sensor positioned within the housing; a processor in communication with the agm sensor wherein the processor is capable of receiving a signal from the agm sensor and analyzing the signal to determine whether the signal is characterizable as a cough; and a power source..
09/04/14
20140249361
System and method for nerve stimulation
A system and method for stimulating a target such as a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined target of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.. .
09/04/14
20140249160
Treatment of hearing and balance impairments with redox-active therapeutics
Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing or balance impairments involving neuronal damage, loss, or degeneration, by administration of a therapeutically effective amount of a redox-active therapeutic. Also provided are improved compositions and methods for treatments requiring administration of a pharmaceutical having an ototoxic side-effect in combination with a therapeutically effective amount of a redox-active therapeutic to treat the ototoxicity..
09/04/14
20140249127
Serine/threonine kinase inhibitors
Compounds of formula i or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of formula i or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed..
09/04/14
20140249075
Methods for reducing cd36 expression
The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1..
09/04/14
20140248360
Nanoparticle tumour vaccines
The present invention provides a vaccine for the prophylactic or therapeutic treatment of a tumour in a mammalian subject, as well as methods of using the vaccine, including in treatment of tumours and in generating a ctl response. The vaccine comprises a plurality of nanoparticles and a pharmaceutically acceptable carrier, salt or diluents.
09/04/14
20140248270
Method for topical treatment of tar-responsive dermatological disorders
A method of treating a tar-responsive dermatological disorder includes topically applying an anhydrous tar composition to skin of a mammal, preferably a human, that is involved with the disorder, the composition including a wax and a therapeutically effective amount of tar for topical treatment of the tar-responsive dermatological disorder, the composition being in liquid form when at a temperature selected from room temperature and a temperature of skin of a mammal upon application of the composition to the skin of the mammal.. .
09/04/14
20140248219
Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein.
08/28/14
20140245468
Non-human animals with modified immunoglobulin heavy chain sequences
Non-human animals, e.g., mammals, e.g., mice or rats, are provided comprising an immunoglobulin heavy chain locus that comprises a rearranged human immunoglobulin heavy chain variable region nucleotide sequence. The rearranged human immunoglobulin heavy chain variable region nucleotide sequence may be operably linked to a heavy or light chain constant region nucleic acid sequence.
08/28/14
20140243910
Bone joining apparatus and method
Provided is a bone joining device suitable for joining a first bone piece to a second bone piece. Also provided is a method of joining a first bone piece with a second bone piece in a living mammal.
08/28/14
20140243588
Implantable stoma ring
The present invention relates to a ring (1) for implantation in patients receiving stoma having (i) an inner ring (2) suitable for fitting an abdominal wall on its outer circumference having an opening (3) suitable for an abdominal organ to pass through the ring to the exterior side (5) and (ii) a lip seal (4) extending over the interior side (5) of the inner ring (2) to seal the stoma opening for use in abdominal surgery. In addition, the present invention is directed to a method of treatment, comprising the surgical introduction of a ring (1) of the invention into the abdominal wall of a mammal in need of abdominal, preferably stoma surgery..
08/28/14
20140243532
Novel precursors of glutamate derivatives
This invention relates to novel precursors suitable for 18f radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18f radiolabeling of glutamate derivatives wherein the obtained 18f radiolabeled glutamate derivatives are suitable for diagnostic imaging by positron emission tomography (pet) of proliferative diseases e.g. Tumor in mammals..
08/28/14
20140243520
Pyrrolopyridines as kinase inhibitors
Compounds of formula i are useful for inhibition of chk1 and/or chk2. Methods of using compounds of formula i and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed..
08/28/14
20140243501
Histone deacetylase inhibitors and synthetic method thereof and use thereof in manufacture of medicaments
The invention provides histone deacetylase (hdac) inhibitors shown as formula i, where r1 to r8 are as defined in the specification. The invention also provides methods for synthesis of these compounds and applications of these compounds in preparing pharmaceuticals for preventing or treating mammal diseases related to the dysregulation of hdac..
08/28/14
20140243401
Methods of screening compounds that are cytotoxic to tumor cells and methods of treating tumor cells using such compound
The invention relates to methods of screening to find compounds that are cytotoxic to tumor cells and methods of treating tumor cells using these compounds. In particular, the invention relates to methods of screening for compounds that inhibit mammalian mitochondrial fatty acid synthase (mmfas) and methods of treating tumor cells using mmfas inhibitors.
08/28/14
20140243318
Salts and polymorphs of 8-fluoro-2--1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
The present invention relates to novel polymorphic forms of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(adp-ribose) polymerase activity including the disease condition such as cancer..
08/28/14
20140243313
Tricyclic compounds useful as neurogenic and neuroprotective agents
The invention disclosed herein is direct to compounds of formula i and pharmaceutically acceptable salts thereof, which are useful in treating neurodegenerative diseases and promoting the generation or survival of neurons in the mammalian brain. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of formula i or a pharmaceutically acceptable salt thereof.
08/28/14
20140243272
Compound and method for treatment of alzheimer's disease
An isolated protein selected from the group consisting of (i) proteins comprising an amino acid sequence having at least 70% identity to the c-terminal domain of lung surfactant protein c precursor (ctprosp-c, “ctc”) from a mammal; and (ii) proteins comprising an amino acid sequence having at least 70% identity to the brichos domain of ctprosp-c from a mammal, is disclosed for treatment of alzheimer's disease in a mammal, including man.. .
08/28/14
20140243258
Methods and compositions for targeting adipose cells in mammals
Methods and compositions are presented for use in diagnostic, imaging or targeting of therapeutic agents to treat obesity/adiposity-associated disorders, where such as compositions and methods identify and use peptides to selectively target adipose tissue stromal cells in mammals, both in vitro and in vivo.. .
08/28/14
20140242692
Mammalian genes involved in toxicity and infection
The present invention relates to cellular proteins that are involved in toxicity and infection or are otherwise associated with the life cycle of one or more pathogens.. .
08/28/14
20140242347
Graft for directed vascular and lymphatic regeneration and methods to guide endothelial cell assembly
Embodiments of the present invention relate to a therapeutic device (graft) comprising a collagen membrane having an aligned uniaxial or biaxial structure such that mammalian cells plated on the membrane align mainly along the direction of the collagen fibrils. In a further aspect, a graft comprising a substantially tubular body, wherein the body has an exterior surface, an interior surface, and at least one lumen extending therethrough such that a fluid flow through the lumen can direct mammalian cell migration.
08/28/14
20140242139
Controlled drug delivery
A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained within at least some of the spaces of the matrix; and (3) a material contained within at least some of the spaces of the matrix to affect diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal..
08/28/14
20140242111
Engineered bacteria for oral delivery of glucoregulatory proteins
Disclosed is an oral delivery system that overcomes major barriers encountered in the gastrointestinal tract, particularly rapid proteolytic degradation and low intestinal permeability. Provided is a method for oral delivery of an engineered microorganism to a mammal where the microorganism produces a macromolecule having a desired bioavailability outcome..
08/28/14
20140242093
Methods and compositions for modulating the innate immune response and/or myogenesis in a mammalian subject
In one aspect, the present invention relates to methods for increasing, decreasing or maintaining the innate immune response in a mammalian subject comprising modulating the expression of dux4-fl, or modulating the expression of beta-defensin 3 (defb103). In another aspect, the present invention relates to methods for increasing, decreasing or maintaining myogenesis or muscle differentiation in a mammalian subject comprising modulating the expression of beta-defensin 3 (defb103).
08/28/14
20140242089
Glycoproteins having lipid mobilising properties and therapeutic applications thereof
A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a zn-α2-glycoprotein, or of a fragment thereof having an apparent molecular mass mr greater than 6.0 kda as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity.
08/28/14
20140242018
Liquid non-ionic salt-free skin and hair treatment composition that contains n-methyl lauroyl glucamide
Compositions and methods for of their use in treating human or other mammalian skin and hair. Non-ionic, salt-free non-solidifying formulations of lauroyl n methyl-c10, c12, c14, c16 alkanoyl-n-methyl-glucamide and alkyl glycosides are disclosed that impart beneficial barrier properties to skin and hair..
08/28/14
20140242009
Bioactive compositions from theacea plants and processes for their production and use
The present invention relates to isolated bioactive compositions containing bioactive fractions derived from theacea plants. The present invention also relates to bioactive topical formulations containing the bioactive compositions.
08/28/14
20140241986
Formulations of fluorinated stilbene suitable for pet imaging
The invention is directed to formulations of lipophilic amyloid beta ligand stilbene and more particularly to formulations which are capable to be administered parenterally e.g. Intravenously, wherein the lipophilic amyloid beta ligand stilbene is a fluorinated stilbene.
08/21/14
20140237630
Screening method
The present invention provides a method of screening a mammal for the onset or predisposition to the onset of a neuropsychiatric disorder. More particularly, the present invention provides a method of screening a mammal for the onset or predisposition to the onset of schizophrenia by screening for a decrease in the functional level of protein 14-3-3ζ.
08/21/14
20140235924
Method of radiotherapy
The invention provides a method for the treatment of soft tissue disease in a mammalian subject (preferably a human or canine subject), said method comprising administering to said subject a therapeutically effective quantity of a soft tissue targeting complex of thorium-227 and a complexing agent, wherein said quantity is such that an acceptably non-myelotoxic quantity of radium-223 is generated in vivo by nuclear decay of the administered thorium-227.. .
08/21/14
20140235735
Protein damage in aging and age-related diseases
The process of aging and the development of age-related diseases are related to the emerging phenotypes of increasingly damaged and progressively malfunctioning proteomes. The present invention provides methods of preventing aging and age-related diseases in mammals by assessment of protein-specific oxidative damage.
08/21/14
20140235688
Treatment of external parasites by oral administration of parasiticidal agents
Pharmaceutically acceptable compositions of fipronil for oral delivery to mammals and methods for use of the compositions to control external parasites, such as fleas and ticks.. .
08/21/14
20140235681
Combination therapy for glaucoma
Disclosed herein is method of treating glaucoma or ocular hypertension comprising administering a prostaglandin agonist and a second therapeutically active agent to a mammal in need thereof, wherein said second therapeutically active agent is selected from: β-blockers, adrenergic agonists, non-selective adrenergic agonists, α2-selective adrenergic agonists, carbonic anhydrase inhibitors, cholinergic agonists, direct acting cholinergic agonists, chlolinesterase inhibitors, glutamate antagonists, ca2+ channel blockers, prostamides, prostaglandins, cannabinoids, and combinations thereof. Compositions and medicaments containing a combination of these two active agents are also disclosed..
08/21/14
20140235649
Use of phosphatase inhibitors or histone deacetylase inhibitors to treat diseases characterized by loss of protein function
A method of treating a mammalian subject afflicted with a disease characterized by a loss of protein function caused by a genetic abnormality associated with the disease comprising administering to the subject a therapeutically effective amount of a protein phosphatase 2a inhibitor or a histone deacetylase inhibitor.. .
08/21/14
20140235619
Agents and methods for treating ischemic and other diseases
This invention relates to methods of screening for modulators of mammalian cell injury cause by trpm7 gene and protein activity, compounds that modulate trpm7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of trpm7 gene and protein activity.. .
08/21/14
20140235601
Use of aromatase inhibitor or estrogen blocker for increasing spermatogenesis or testosterone levels in males
The use of an aromatase blocker or an estrogen blocker is described in a method for increasing spermatogenesis and seritolli cell function, and/or improving leydig cell function, in order to to increase endogenous testosterone levels in a male mammal. The levels of active materials used are significantly lower than the levels of these materials used to treat female estrogen sensitive tumors..
08/21/14
20140235564
Methods for treating neural cell swelling
A composition comprising a novel ca2+-activated, [atp]i-sensitive nonspecific cation (ncca-atp) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [ca]i.
08/21/14
20140235554
Ophthalmic formulation derived from silk protein
An ophthalmic composition is described for the treatment of dry eye syndrome in a human or mammal. The composition comprises an aqueous solution including an effective amount of silk protein.
08/21/14
20140235544
Disease treatment via antimicrobial peptides or their inhibitors
The invention provides methods for the treatment of disease and promotion of healing that include providing a therapeutically effective amount of a mammalian antimicrobial peptide (amp) or analog thereof, in particular a cathelicidin or cathelicidin fragment or cathelicidin analog, thereby treating the disease in the subject in need thereof. The invention also provides specific analogs or fragments of cathelicidin that function as agonists, as do endogenous cathelicidins, or as either dominant negatives or as inhibitors to endogenous cathelicidin or to other endogenous amps or that compete with pro-inflammatory agents or fragments of amps on cognate receptors without inducing disease..
08/21/14
20140235529
Aromatic-cationic peptides and methods for using same
The present disclosure provides methods of preventing or treating renal ischemia-reperfusion injury in a mammalian subject and methods for chronic treatment of arvd, including administering an effective amount of an aromatic-cationic peptide to a subject in need thereof. The methods include administering aromatic-cationic peptides to prevent or treat renal injury during the treatment of renal artery stenosis.
08/21/14
20140234966
Albumin formulation and use
The invention relates to a new formulation of albumin, a method for producing the albumin formulation and to uses of the albumin formulation, for example in cell culture such as mammalian cell culture and particularly in stem cell culture.. .
08/21/14
20140234965
Triazine derivatives as differentiation catalysts
A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (i), wherein x is independently —nr4— or —o—, r4 is hydrogen or c1-6-alkyl; r1 is hydroxy, c1-6-alkyl, c1-6-alkoxy, carboxy, c1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, c1-6-alkylamino, or di-c1-6-alkylamino, the c1-6-alkyl or -alkoxy residue being optionally substituted with one or more r5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; r2 is hydrogen, aryl, heteroaryl, or c1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more r1 substituents, and where the c1-6-alkyl is optionally further substituted with one or more r5 substituents; and r3 is selected from hydrogen, halo, nr4r7, or7, sr7, and r7, where the same options apply for r7 as for r2; with the proviso that the compound of formula (i) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.. .
08/21/14
20140234957
Engineered cellular pathways for programmed autoregulation of differentiation
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type.
08/21/14
20140234905
Cell culture improvements
The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture..
08/21/14
20140234888
Method for improved selection of therapeutic agents
The current invention comprises a method of selection of therapeutic agents for treatment of a particular disease in humans or other mammals in which the ratio of the concentrations of thiol (—sh) and disulfide (—ss—) groups is determined in the blood. The therapeutic agent to be tested may be used to treat a neoplastic, infectious, immunological, inflammatory, or other disorder that involves (but is not limited to) the following physiological systems: respiratory, cardiovascular, genitourinary, gastrointestinal (including the liver and pancreas), neurological, musculoskeletal, immunological, and skin..
08/21/14
20140234863
Immunoassay methods
The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.. .
08/21/14
20140234837
Epigenetic marker for the identification of natural killer cells
The present invention relates to a method, in particular an in vitro method for identifying a subgroup of natural killer cells of a mammal, preferably cd3−, non t-lymphocyte derived nk cells, which often express the surface proteins cd56 and/or cd16, comprising analyzing the accessibility of the genomic dna for osbpl, such as osbpl5, to bisulfite conversion and/or the methylation status of at least one cpg position in the genes for osbpl, such as osbpl5, in particular in their upstream and/or downstream regulatory regions, the promoter, introns, exons and introns exon borders and other conserved regions of said genes, wherein an increase of the accessibility of the genomic dna and/or a demethylation in the sample as analyzed is indicative for said subgroup of nk cells. The analyses according to the invention can identify cd56+ cells and distinguish them from all other cells such as, for example, either cd56− and/or cd56 bright cells.
08/21/14
20140234407
Method for increasing lactose tolerance in mammals exhibiting lactose intolerance
The method for increasing lactose tolerance in subjects exhibiting lactose intolerance symptoms implements a protocol where the subjects ingest a gradually increasing amount of lactose containing product over a six week period. At various points during the six week period the subject ingests the lactose containing product once a day and then twice a day.
08/21/14
20140234400
Targeted lipid-drug formulations for delivery of drugs to myeloid and lymphoid immune cells
A method of preferentially delivering an active agent to an immune cell, such as a myeloid progenitor cell, a dendritic cell, a monocyte, a macrophage or a t-lymphocyte, or other cell type restricted to a functional organ system or an anatomic entity, of a mammalian subject by administering a lipid-drug complex to the subject. The lipid-drug complex is comprised of an active agent, such as a drug, and an outer surface with a targeting ligand that binds a marker on the surface of the immune cell or other cell type that is infected with or susceptible to infection with an infectious agent.
08/21/14
20140234398
Dissolution of arterial plaque
Some embodiments of the present invention provide pharmaceutical formulations, for treating atherosclerosis in a mammal, including a bile acid and/or a terpene atherosclerotic plaque emulsifier. Some embodiments provide methods for administering such pharmaceutical formulations.
08/21/14
20140234378
Lobster hemolymph as a utility for treatment of mammalian tissue lesions
The invention is crustacean hemolymph as a utility for the pharmaceutical and/or cosmetic treatment of viral and other neoplastic or pre-neoplastic mammalian tissue lesions. The method comprises topically administering to mammalian tissue a formula that is made from lobster hemolymph—neat; or lobster hemolymph extracts; or lobster hemolyph in combination with certain carriers, binders; or as an adjuvant.
08/21/14
20140234361
Novel expression vectors and uses thereof
A method for treating an hiv disease in a subject in need of said treatment, comprising administering to the subject a therapeutically effective amount of a dna vaccine comprising an expression vector and a pharmaceutically acceptable excipient, where the expression vector comprises: (a) a heterologous promoter operatively linked to a dna sequence encoding a nuclear-anchoring protein, where the nuclear-anchoring protein comprises: (i) a dna binding domain which binds to a specific dna binding sequence, and (ii) a functional domain of the bovine papilloma virus type 1 e2 protein, where the functional domain binds to a nuclear component; (b) a multimerized dna sequence that forms a binding site for the nuclear anchoring protein; and (c) at least one expression cassette comprising a dna sequence encoding a protein or peptide that stimulates an immune response specific to the protein or peptide; where the expression vector lacks an origin of replication functional in mammalian cells.. .
08/21/14
20140234342
Nkp46-mediated nk cell tuning
The present invention relates to compounds (e.g. Antibodies) that specifically bind and inhibit nkp46.
08/21/14
20140234322
Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury
Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non-human mammal.
08/21/14
20140234299
Therapies for chronic renal failure using one or more integrin antagonists
The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certain integrin antagonists..
08/21/14
20140234297
Antibody constant domain regions and uses thereof
The invention provides recombinant protein (e.g., a recombinant antibody or soluble receptor) having (i) a binding domain capable of specific binding to an epitope (for example an antibody variable domains, a receptor, a growth factor, a cytokine, or a fragment of any of the foregoing which is capable of specifically binding the desired epitope) and (ii) an effector domain comprising a constant domain region which is derived from immunoglobulin of a first species which is a companion mammal, e.g. Dog, cat, or horse, having engineered substitutions at one or more positions and having an altered interaction with one or more fcrs or other ligands, and optionally enhanced effector function, relative to the parent constant domain region..
08/21/14
20140234286
Skeletal muscle regeneration promoter
Provided is a skeletal muscle regeneration promoter for a muscular disorder or myopathy comprising a chondroitinase as an active component, which skeletal muscle regeneration promoter enhances, when administered into a muscular fiber of a mammal with the muscular disorder or myopathy, the regeneration of such a muscular fiber. The above-mentioned chondroitinase degrades chondroitin sulfate that is present at the outer perimeter of the above-mentioned muscular fiber; and thereby inhibition of the regeneration of the muscular fiber by the above-mentioned chondroitin sulfate disappears, which makes it possible to enhance the regeneration and enlargement of such a muscular fiber..
08/21/14
20140234260
Compositions and methods for probiotic recolonization therapies
The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of bacteroides, eubacteria, fusobacteria, propionibacteria, lactobacilli, anaerobic cocci, ruminococcus, e.
08/21/14
20140234256
Commensal bacteria as signal mediators within a mammalian host
Genetically engineered cells and microorganisms are provided for preventing or ameliorating diseases through genetically engineered quorum signaling. Therapeutic methods for using the cells and microorganisms to prevent or ameliorate diseases are also provided.
08/21/14
20140234254
Heteroaromatic compounds as pi3 kinase modulators and methods of use
The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (pi3 kinases) and mtor, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
08/21/14
20140234250
Methods and compositions for improving appearance and formation of scar tissue
This invention relates to methods and compositions for degrading collagen in mammalian skin, thereby improving the appearance and/or reducing the size of a closed wound, which may be a scar or a keloid and cellulite or other conditions wherein excessive collagen is a problem.. .
08/21/14
20140234249
Methods and compositions for improving appearance and formation of scar tissue
This invention relates to methods and compositions for degrading collagen in mammalian skin, thereby improving the appearance and/or reducing the size of a closed wound, which may be a scar or a keloid and cellulite or other conditions wherein excessive collagen is a problem.. .


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