|| List of recent Mammal-related patents
|Radio-frequency system for skin treatment including a roller with an electrode and a skin treatment|
A method of treating a skin tissue relief feature (3) in mammalian, in particular human, skin tissue (1) is provided. The method comprises the steps of: determining a perimeter (4) of the relief feature and inducing contraction of skin tissue areas (5) present on opposite sides of the relief feature in positions adjacent to respective portions of the perimeter in a direction of contraction substantially parallel to a skin surface and substantially normal to the respective portions of the perimeter.
Koninklijke Philips N.v.
|Electronic pill for delivery of powder medication|
The invention relates to an electronic pill (102) for delivery of a medication (104) inside a mammal. The electronic pill (102) comprises a reservoir (106) for releasing the medication (104) in response to a predefined level of pressure.
Medimetrics Personalized Drug Delivery
|Devices and systems for obtaining impedance data|
Devices and systems to measure luminal organ parameters using impedance. In at least one embodiment of an impedance device of the present disclosure, the impedance device comprises an elongated body having a distal body end and a pair of detection electrodes positioned in between a pair of excitation electrodes located at or near the distal body end, the pair of detection electrodes configured to obtain one or more conductance values within a mammalian luminal organ within a field generated by the pair of excitation electrodes, wherein a measured parameter of the mammalian luminal organ can be calculated based in part upon the one or more conductance values obtained by the device and a known distance between the pair of detection electrodes..
|Real-time in vivo measurement of the 3d angular orientation of cardiovascular structures|
This document provides materials and methods for determining three-dimensional spatial orientations of blood vessels, cardiac valves, and other anatomical structures within a mammal during a clinical procedure. For example, materials and methods for determining the three-dimensional spatial location, orientation, and size of a cardiac valve within a mammal during a trans-catheter cardiac valve implantation or replacement procedure are provided..
Mayo Foundation For Medical Education And Research
|Substituted pyrazolone compounds and methods of use|
The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
Or pharmaceutically acceptable salts thereof, wherein q, g, ring a, ring b, r1, r2, r3, r4, r5, r5a, r6, r7, r8, r9, r10, r11, r12, r13, r14, r15, r16, r17, r18, r19, r20, r21, r22, r23, r24, and m are defined herein. The novel purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals.
|Murine anti-ny-eso-1 t cell receptors|
The invention provides an isolated or purified t cell receptor (tcr) having antigenic specificity for ny-eso-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions.
The United States Of America, As Represented By The Secretary, Department Of Health & Human Serv.
|Sparc and methods of use thereof|
The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the sparc protein or rna in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or rna from the tumor, a sparc protein or rna detection and quantification means, control rnas, and rules for predicting the response of the tumor based on the level of sparc protein or rna in tumor..
Abraxis Biosciences, Llc
|Methods for diagnosing osteoarthritis|
Methods for managing osteoarthritis, in a human or other mammalian subject, comprising the measurement of certain cytokines and growth factors in a tissue sample of a subject, including one or more of platelet-derived growth factor ab (pdgf-ab), platelet-derived growth factor bb (pdgf-bb), and epidermal growth factor (egf). Tissue samples may be whole blood, blood fractions, urine, saliva, and synovial fluid.
Biomet Biologics, Llc
|Peptide-oligourea chimeric compounds and methods of their use|
The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal.
In vitro reconstituted plant virus capsids for delivering rna genes to mammalian cells
The invention provides compositions of matter comprising a cowpea chlorotic mottle virus capsid protein (ccmv cp) and a ribonucleic acid, as well as methods for using such compositions. In such compositions, the cowpea chlorotic mottle virus capsid protein envelops the ribonucleic acid so as to for a capsid that can inhibit the degradation of the ribonucleic acid (e.g.
The Regents Of The University Of California
Monoclonal antibodies that specifically bind to m.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % q mediated diseases..
The Regents Of The University Of California
Device for online measurement of neurotransmitters using enzymatic reactors
The invention relates to a device and a method for measuring neurotransmitters in the brain dialysate of mammals using enzymatic reactors specific to a certain neurotransmitter, which generate fluorescent derivatives when mixed. The mixture is introduced into an incubation chamber and passes through a temperature controlling system in order to set it to the optimum enzymatic reaction temperature, and the fluorescent derivative generated is passed through a flow fluorescence cell located inside the incubation chamber, where the liquid is impacted with a laser light source via an optical fibre.
Compositions and methods for enhancing the viability of animal cells, tissues, and organ explants
Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity..
Warsaw Orthopedic, Inc.
Devices and methods for enhancing bone growth
The present invention is generally related to implants for compensating bone loss in mammalian body, and to devices and methods for replacing or creating facial bone. The present invention relates to devices and methods for implanting an implantable device in a subject's body.
Medicinal composition of extract of seed of emblica officinalis and preparing the same
A composition having an extract of seed of emblica officinalis. Methods of preparing extract of seed of emblica officinalis.
Formulation of dual cycloxygenase (cox) and lipoxygenase (lox) inhibitors for mammal skin care
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—free-b-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (cox) and lipoxygenase (lox) enzymatic activity in normal, aged and damaged dermal cells and tissues.
Protein expression analyses for identifying genotoxic compounds
The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal.
Merck Patent Gmbh
Therapeutic micro rna targets in chronic pulmonary diseases
The present invention relates to the identification of micrornas of the mir-148 family that are involved in the pathogenesis of chronic pulmonary diseases. The present invention relates to micro rna of the mir-148 family selected from mir-148a, mir-148b and mir-152 for use in the diagnosis, prognosis, prevention and/or therapy of a chronic pulmonary disease.
Therapeutic biologic for treatment of hepatocellular carcinoma
The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian plvap protein. These agents specifically target hcc tumors and treat the hcc.
China Synthetic Rubber Corporation
Ophthalmological vehicle system for drugs, ophthalmological kit and also use of an ophthalmological composition
The present invention relates to an ophthalmological vehicle system for the permeation and/or for the active substance transport of ophthalmological active substances through the cornea and/or the sclera of the eye of mammals. This vehicle system assists the transport of the active substances through the cornea and/or the sclerotic tissue of the eye.
F. Holzer Gmbh
Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies
The present invention relates to tolerogenic mammalian dendritic cells (idcs) and methods for the production of tolerogenic dcs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
Methods, compositions, cells, and kits for treating ischemic injury
The methods, compositions, cells and kits described herein are based on the discovery that stem cells, when injected into ischemic tissue of mammals, can be protected by preconditioning of the ischemic tissue with hypoxia-regulated human vegf and human igf-1. Methods, compositions, cells and kits for treating tissue injured by ischemia or at risk of ischemic injury in a subject are thus described herein..
University Of Miami
Separatone-based protein expression and purification platform
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, such as that of e. Coli, yeast, bacillus subtilis or other prokaryotes, insect cells, mammalian cells, etc.
Board Of Trustees Of The University Of Arkansas
Methods to decrease susceptibility to asthmatic bronchoconstriction
Methods and compositions are described for reducing airway reactivity and the susceptibility to asthmatic bronchoconstriction that involve increasing sphingolipid content in airways and lungs of a mammalian subject.. .
Calcium-binding agents induce hair growth and/or nail growth
This invention provides novel methods for inducing hair growth and/or inhibiting hair loss and/or inducing nail growth in a mammal. In various embodiments the methods involve administering, e.g., to a mammal in need thereof, a calcium-binding peptide and/or peptide-like moiety in an amount sufficient to induce hair growth and/or to inhibit hair loss.
C3 Jian, Inc.
Easy removal adhesive article
An elongate adhesive article having a length substantially greater than a width includes a backing layer having an adhesive layer and a single weakened region formed of a removable strip of backing layer that is oriented substantially perpendicular to the article length. The removable strip of backing layer is at least partially defined by a pair of lines of weakness separated by a gap of between about 2 and about 15 mm.
Noninvasive electrocardiographic estimating mammalian cardiac chamber size and mechanical function
The present disclosure generally relates to systems and method of a noninvasive electrocardiographic (ecg) technique for characterizing cardiac chamber size and cardiac mechanical function. A mathematical analysis of three-dimensional (3d) high resolution ecg data may be used to estimate chamber size and cardiac mechanical function.
Method of detecting potential deep tissue injury
A system for determining a clinically relevant temperature differential between a predetermined area of interest, as defined herein, on the body surface of a mammal and a control area on the body surface of said mammal, said system comprising: a visual and thermal image capturing device, said image capturing device comprising: a housing, a means for capturing a digital visual image within said housing; and a means for capturing a digital thermal image within said housing; a display apparatus, said display apparatus comprising means for showing said captured visual image and said captured thermal image; and a computing apparatus, said computing apparatus operatively connected to said image capturing device and to said display apparatus, said computing apparatus comprising: a means for selecting a control area on the surface of the skin; a means for determining an temperature of said control area; a means for selecting an area of clinical interest within said visual image; a means for calculating plane geometric features of said selected area of clinical interest; a means for overlaying said digital image onto said thermal image in a desired orientation on said display apparatus; and a means for applying a unique pixel value to a specific predetermined temperature range on said thermal image.. .
Low organic extractable depth filter media processed with solvent extraction method
Provided is a primary clarification depth filtration process of cell-culture feeds, including chemically treated flocculated feeds, containing target biomolecules of interest such as mabs, mammalian cell cultures, or bacterial cell cultures, utilizing a primary clarification depth filtration device containing a media with significantly lower flushing requirements, resulting in lower levels of organic extractables released after media flushing, and increased throughput for the pre-treated feed streams, without the use of a primary clarification centrifugation step or primary clarification tangential flow microfiltration step. The primary clarification depth filtration device used in the primary clarification of fluid cell culture feeds, including chemically treated flocculated feeds containing flocculated cellular debris and/or colloidal particulates having a particle size distribution of about 0.5 μm to 200 um, contains a porous depth filter media having porous layers of varying pore ratings, and achieves the desired level, of total organic extractables (1-3 ppm) measured in the feed filtered through the media with, significantly lower flushing requirements.
Aqueous based capsaicinoid formulations and methods of manufacture and use
Capsaicinoid formulations and methods of treatment are disclosed herein which can be utilized to treat/attenuate pain in mammals. Typically, administration is via injection at a discrete site to provide pain relief for an extended period of time.
Polyhydroxylated pentacyclic triterpene acids as hmg-coa reductase inhibitors
The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (i) for use as hmg-coa reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the hmg-coa reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio.
Compositions and methods for inducing myoblast differentiation and myotube formation
Provided herein are methods of inducing differentiation of a mammalian myoblast into a mammalian myocyte that include contacting a mammalian myoblast with an oligonucleotide that decreases mitogen-activated protein kinase kinase kinase kinase 4 (map4k4) mrna expression in a mammalian myoblast or myocyte. Also provided are methods of inducing mammalian myoblasts or myocytes to form a myotube that include contacting two or more mammalian myoblasts or two or more mammalian myocytes with an oligonucleotide that decreases map4k4 mrna expression in a mammalian myoblast or myocyte.
Means to facilitate food intake and food retention
The disclosure provides for means for a method to facilitate food intake and food retention in a mammal by applying a sufficient dose of a local anesthetic drug in the lumen of the pharyngeal-esophageal-gastric-duodenal tract before or during or after eating. The local anesthetic can be amethocaine, articaine, benzocaine, bupivacaine, chloroprocaine, cinchocaine, cyclomethycaine, dibucaine, diethocaine, etidocaine, larocaine, levobupivacaine, lidocaine, lignocaine, mepivacaine, novocaine, piperocaine, prilocaine, procaine, proparacaine, propoxycaine, qx-222, qx-314, ropivacaine, tetracaine, trimecaine, menthol, eugenol or a safe pharmaceutical formulations of tetrodotoxin, saxitoxin, or neosaxitoxin.
Substituted acyloxyamidines as hcv ns3/4a inhibitors
Or a pharmaceutically acceptable salt thereof, in which a, g, r1 and r2 are as defined herein. The compounds and pharmaceutical compositions of the compounds are suitable for the treatment of hcv infection in mammals and are also useful to modulate or inhibit ns3/4 dimerization..
Crystalline forms of an androgen receptor modulator
Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-n-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity..
Quinazoline derivatives as kinase inhibitors
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases.
Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or typanosoma cruzi infection in a mammal.. .
Broad antiviral therapy with membrane modifying oxysterols
This invention relates, e.g., to a method for inhibiting the growth and/or proliferation and/or infectivity of a virus in a cell, such as a mammalian cell (e.g. For inhibiting entry of the virus into the cell), comprising administering, or causing to be administered, to the cell, 25-hydroxycholesterol (25hc) in an amount sufficient to inhibit the growth and/or proliferation and/or infectivity of the virus in the cell.
Detection, isolation and analysis of rare cells in biological fluids
The invention provides a method for isolating or enriching a rare cell from a biological fluid of a mammal employing an antibody that binds a cell-surface antigen of the rare cell. The immobilized antibody is incubated with a sample of biological fluid that includes the rare cells and a plurality of other cells so as to form an antibody-rare cell complex.
Stem cells from the mammalian neural plate
The present invention relates to methods for deriving novel stem cells from the mammalian early neural plate.. .
Ex vivo maturation of islet cells
The invention relates to methods for promoting maturation of islet cells from pre-weaned mammals for the purpose of optimizing the islets for their use as donor tissue for xenotransplantation. The method of the invention removes the pancreas from donor animals and reduces the pancreas tissue to fragments that are greater than the size of an intact islet while retaining islets in their whole, insulin-producing condition.
Multiplexed chromatography-immunoassay the characterization of circulating immune complexes
Thus, herein is reported a method for analyzing/characterizing circulating immune complexes (cics) formed in vivo comprising a size-exclusion chromatography of a sample obtained from a mammal to which the drug had been administered at least once for determining the weight/size of the immune complexes, optionally a second non-sec chromatography, and at least one immunoassay, whereby the immune complex is characterized by the correlation of the immune complex size and the immunoassay result/read-out. Also reported herein is the use of a method as reported herein for determining a correlation to altered pharmacokinetics, for determining loss or reduction of efficacy, for determining neutralization of natural counterparts of the drug, for determining immune and hypersensitivity reactions, including serum sickness/type iii hypersensitivity reaction/immune complex-mediated disease..
Kits, compositions and methods for detecting a biological condition
The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.. .
System for keeping alive and transporting skin biopsies and applications of said system
Disclosed is an in vitro or ex vivo method for preserving and/or keeping alive mammalian, preferably human skin biopsies, enabling to transport it and, if applicable, to culture it. Also disclosed is a skin biopsy thus preserved and obtained by such a method and relates to its use as a model especially in a kit for screening or selecting cosmetic or therapeutic compounds..
A method for a mammal to remove toxins from the mammal's system, the method includes the steps of providing instructions for the mammal to ingest a set of substances periodically according to a set of instructions and to practice a set of wellness regimen periodically. The set of instructions comprises instructing the mammal to periodically ingest a predetermined amount of a rejuvenating substances providing the mammal with support of antioxidant activity, cytokine balance, detoxification, gastrointestinal and liver health; a predetermined amount of soluble dietary fiber substances; a predetermined amount of grasses; a predetermined amount of an antioxidant substances providing the mammal with support of antioxidant activities; predetermined amount of omega fatty acid substances and a predetermined amount of green tea.
Dietary supplements for promotion of growth, repair, and maintenance of bone and joints
The present invention provides a dietary supplement that promote the growth, repair, and maintenance of mammalian bone and joint connective tissue. In particular, the dietary supplement comprises a combination of at least one metal chelate and at least one chondroprotective agent..
Intrathecal administration of mtor inhibitors for the therapy of neurodegenerative, neuroinflammatory and neurooncologic diseases
The invention relates to the use of inhibitors of the enzyme mtor kinase (mammalian target of rapamycin) in the treatment of neuro-oncologic diseases, in particular tuberous sclerosis, neurodegenerative diseases, in particular alzheimer's disease, and neuroinflammatory diseases, in particular multiple sclerosis and primary progressive aphasia, via intrathecal, or preferably intraventricular, administration of said inhibitors.. .
Treatment of inflammatory bowel disease
The invention relates to the treatment of inflammatory bowel disease, also termed ibd, including ulcerative colitis and crohn's disease. To this end, the invention proposes clinoptilolite having a particle size between 0.2 and 1 μm for use in the treatment of inflammatory bowel disease, also termed ibd, in mammals and humans.
Mtb-c vaccine against asthma
The invention relates to an agent for the treatment or prevention of an allergic condition, such as asthma, in a mammal. The agent comprises fragments of a mycobacterium tuberculosis-complex (mtb-c) strain.
Solid dressing for treating wounded tissue
Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator, wherein the fibrinogen is present in an amount between 3.0 mg/cm2 of the wound facing surface of the dressing and 13.0 mg/cm2 of the wound facing surface of the dressing. Also disclosed are methods for treating wounded tissue..
Cationic lipid vaccine compositions and methods of use
The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of augmenting an immune response in a mammal, and methods of treating a disease in a mammal utilizing the vaccine compositions..
Humanized antibodies targeting the ec1 domain of cadherin-11 and related compositions and methods
The present invention relates to humanized antibodies that specifically bind an ec1 domain of a mammalian cadherin-11 protein and compositions (e.g., pharmaceutical compositions) comprising such antibodies. The invention also relates to methods for treating cadherin-11-mediated disorders in a mammalian subject by administering a therapeutically effective amount of a humanized antibody of the invention.
Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. Via injection, transplantation, or implantation) into a site of soft tissue.
Fusion molecules and il-15 variants
The instant invention provides soluble fusion protein complexes and il-15 variants that have therapeutic and diagnostic use, and methods for making such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and il-15 variants of the invention..
Compositions containing theobromine and their use in treating tooth hypersensitivity
Compositions and methods for reducing oral sensitivity, increasing the systemic health of a mammal, occluding a dentinal tubule within a mammalian tooth, and/or depositing a precipitate on the surface of a mammalian tooth are provided, said compositions comprising theobromine (3,7-dimethylxanthine, the principal alkaloid in theobroma cacao).. .
One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used.
Respiratory mask having gas washout vent and making the mask
A washout vent for a mask for use with a system for supplying breathable gas pressurized above atmospheric pressure to an airway of a mammal for treatment of sleep disordered breathing, includes a solid mask section and a vent orifice extending through a thickness of the solid mask section and adapted for gas washout. The vent orifice includes opposed side walls providing a flow passage that allows gas to flow along the opposed side walls from an interior of the mask to atmosphere in use, and the opposed side walls defining at least a portion of a conic section having a length substantially greater than its width.
Bone screw fastener
An improved bone screw for humans or mammals is a bone screw having exposed surfaces along a shank and threads extending from the shank with one or more selected portions of the exposed surfaces having a 3-dimensional pattern. The pattern provides enhanced resistance to thread loosening when affixed to bone.
Vivex Biomedical Inc.
Dosing regimen for janus kinase (jak) inhibitors
The present invention provides a method for treating allergic dermatitis, atopic dermatitis, or one or more symptoms thereof in a mammal in need, which method comprises administering to the mammal a first therapeutically effective dose of a janus kinase (jak) inhibitor twice a day for a number of days sufficient to ease or eliminate one or more clinical signs in the mammal, followed by a second therapeutically effective dose of the jak inhibitor at a reduced frequency.. .
Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in mammals afflicted therewith, comprising administering to the mammal an effective amount of a non-retinoid antagonist compound or a pharmaceutically acceptable salt thereof.. .
The Trustees Of Columbia University In The City Of New York
Multivalent peptoid oligomers, pharmaceutical compositions and methods of using same
The peptoid oligomers are prepared as modulators of androgen receptor (ar), and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals, including humans, associated with unwanted or aberrant ar activity. The present peptoid oligomers are particularly valuable for the treatment of subjects with cancer..
Method and kit for the classification and prognosis of wounds
The present invention relates to a method and kit for the classification and prognosis of wounds of mammalian, in particular in human. The method defines a molecular signature that enables one to characterize a pathological wound healing such as chronic or non-healing wound..
Ecole Normale Superieure
Cell culture improvements
The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture..
Formulations and process for isolating viable microorganism from positive blood cultures
Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including s. Pneumoniae, from positive blood culture samples.
Becton, Dickinson And Company
Methods for isotopically labeling biomolecules using mammalian cell-free extracts
Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule.
Pierce Biotechnology, Inc.
Mir-200 family induces mesenchymal-to-epithelial transition (met) in ovarian cancer cells
The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more mir-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more mir-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis.
Georgia Tech Research Corporation
Compositions for stimulation of mammalian innate immune resistance to pathogens
Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a stir composition to the individual.. .
The Board Of Regents, The University Of Texas System
Multipotent vascular stem cells and methods of use thereof
A substantially enriched mammalian multipotent vascular stem cell (mvsc) population is provided, as well as compositions comprising the population. Methods are provided for the isolation, purification, and culture of the mvscs.
The Regents Of The University Of California
Multimodal imaging methods using mesoporous silica nanoparticles
The invention provides particles useful for sequential imaging or for diagnostics or therapeutics. Disclosed is a method to image diagnostic or therapeutic cells in a mammal, comprising: introducing to a mammal a composition comprising mammalian cells comprising mesoporous silica nanoparticles (msns) comprising a lanthanide, a fluorophore and an agent detectable by ultrasound; applying ultrasound and/or a magnetic field to the mammal and recording ultrasound and/or magnetic resonance images that include the msns; and detecting the presence, location or amount of the msns in the mammal..
Iowa State University Research Foundation, Inc.
Method for changing condition of eyelid by administering complete freund's adjuvant
A method for changing a condition of an eyelid of a mammal excluding a human, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.. .
Santen Pharmaceutical Co., Ltd.