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Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications. Subscribe to the Mammal RSS feed to automatically get the update: related Mammal RSS feeds. RSS updates for this page: Mammal RSS RSS


Date/App# patent app List of recent Mammal-related patents
12/11/14
20140364683
 Illumination signal, system and method patent thumbnailIllumination signal, system and method
An illumination system is provided comprising a light source and a controller and being configured to provide an illumination signal (15) for, when perceived by a mammalian, in particular human, subject, inducing relaxing in the subject. The signal comprises a plurality of light pulses (17) having a pulse duration (t17) and being separated by inter-pulse intervals (19).
12/11/14
20140364467
 Chemical inducers of neurogenesis patent thumbnailChemical inducers of neurogenesis
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo.
12/11/14
20140364451
 Tropinol esters and related compounds to promote normal processing of app patent thumbnailTropinol esters and related compounds to promote normal processing of app
In various embodiments, compositions and methods are provided for treatment and/or prevention of amyloidogenic diseases. In certain embodiments, the methods entail administering an effective amount of a tropinol ester to a subject in need thereof for prophylactic or therapeutic effect.
12/11/14
20140364370
 Combination therapies using cyclosporine and aromatic cationic peptides patent thumbnailCombination therapies using cyclosporine and aromatic cationic peptides
The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, and one or more additional active agents such as cyclosporine..
12/11/14
20140363873
 Compositions and methods for the diagnosis and treatment of tumor patent thumbnailCompositions and methods for the diagnosis and treatment of tumor
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.. .
12/11/14
20140363815
 Methods and kits for detection of methylation status patent thumbnailMethods and kits for detection of methylation status
The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmc) and/or 5-methylcytosine (5mec). In some embodiments, the present invention relates to methods and kits for detection of 5hmc and/or 5mec in nucleic acid (e.g., dna, rna).
12/11/14
20140363470
 Pharmaceutical formulations and the use thereof for the treatment of peanut allergy patent thumbnailPharmaceutical formulations and the use thereof for the treatment of peanut allergy
The present invention relates to compositions which can be used in immunotherapy and especially to compositions which can be used in immunotherapy for mammals, such as human mammals, suffering from peanut allergy. The present invention further relates to the use of the present compositions for the therapeutic treatment for desentizing the immune system of a mammal suffering from an allergy by immunotherapy and the use of the present compositions in a prophylactic treatment of a mammal with high predisposition to develop a certain allergy.
12/11/14
20140363459
 Synthetic capsid proteins and uses thereof patent thumbnailSynthetic capsid proteins and uses thereof
The present invention relates to synthetic proteins and the uses thereof. More particularly, the invention relates to synthetic circovirus type capsid proteins with improved properties.
12/11/14
20140363450
 Oxidized cardiolipin as a novel pro-inflammatory factor patent thumbnailOxidized cardiolipin as a novel pro-inflammatory factor
Low levels of antibodies reactive with oxidised cardiolipin (oxcl) in mammals are related to an increased risk of developing cardiovascular diseases, auto-immune diseases or inflammatory conditions. High levels can have a protective function and in general there is a negative association between manifestations of these conditions and antibodies against oxcl.
12/11/14
20140363442
 Therapeutic cd47 antibodies patent thumbnailTherapeutic cd47 antibodies
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to cd47 of multiple mammalian species, block the binding of sirpalpha and tsp1 to cd47, promote phagocytosis of susceptible cancer cells, and reverse tsp1 inhibition of nitric oxide signaling, as well as monoclonal antibodies and antigen binding fragments thereof that compete with the former for binding to cd47 and that exhibit similar biological activities. Also provided are combinations of any of the foregoing.
12/11/14
20140363410
Lactobacillus reuteri dsm 17938 for the development of cognitive function
The invention relates to lactobacillus reuteri dsm 17938 for promoting the establishment of healthy and normal cognitive function in young mammals. In particular, the invention relates to the use of lactobacillus reuteri dsm 17938 for promoting development of the brain structures responsible for cognitive functions (e.g.
12/11/14
20140363409
Lactobacillus reuteri dsm 17938 for the development of the enteric nervous system
The invention relates to lactobacillus reuteri dsm 17938, and compositions comprising lactobacillus reuteri dsm 17938, for promoting the healthy development and/or repair of the enteric nervous system in mammals. Humans or animals and, in particular, a foetus, pre-term or term-born infant, toddler or child may benefit from the invention.
12/11/14
20140363407
Neural stem cell therapy for obesity and diabetes
Methods are provided of treating obesity or an obesity comorbidity in a mammalian subject comprising administering to the subject an amount of an agent effective to treat obesity or the obesity comorbidity, which agent inhibits (i) iκb kinase β (ikkβ) activation of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) or (ii) notch signaling in a manner so as to permit the agent to enter the hypothalamus of the subject. Assays are also provided for identifying candidate agents for treating obesity..
12/11/14
20140363394
Formulation having mobilizing activity
The present innovation relates to a novel formulation capable of increasing the amount of stem cells and progenitor cells in circulation in the peripheral blood of a mammal; the formulation is characterized in that it contains defibrotide in combination with at least one haematopoietic factor having the capacity to mobilize haematopoietic progenitors, preferably g-csf. In one embodiment, the formulation includes two separately administrable formulations, one containing a haematopoietic factor having the capacity to mobilize haematopoietic progenitors and the other containing defibrotide.
12/11/14
20140363377
Procaspase 8-mediated disease targeting
The invention provides compositions and method for delivering a therapeutic or diagnostic agent to a disease site in a mammal, the method comprising administering to the mammal a therapeutically or diagnostically effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises the therapeutic or diagnostic agent coupled to a procaspase 8 polypeptide and a pharmaceutically acceptable carrier.. .
12/11/14
20140363373
Method for combined imaging and treating organs and tissues
The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized, fully human), partial antibody, fab fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell.
12/04/14
20140358234
End cap and connector for a spinal implant
The present invention is a spinal implant that can be inserted into a surgically created cavity of one or more regions of the mammalian spine. Among other things, the biocompatible implant and end cap or biocompatible implant, connector and end cap combinations can assist with the restoration of the normal anatomic spinal alignment and spinal stability..
12/04/14
20140358199
Self-administrable method, system and apparatus for non-invasive neurostimulation therapy of the brain
The present invention is a portable non-invasive apparatus, system, and method for performing light therapy or photobiomodulation upon the brain tissues through the nostrils of a living mammalian subject for the medical purpose of stimulating the brain in-vivo. In marked difference to conventionally known therapeutic procedures, the present invention utilizes the intranasal pathway as the point of anatomic access; and follows established principles for the conceptual approach that irradiation of the brain tissue with low level light energy of certain fixed parameters would achieve major therapeutic effects in-vivo.
12/04/14
20140358097
Suction device and dressing
Some embodiments are directed to a system 10 for the application of topical negative pressure therapy to a site 18 on the body of a mammal. Some embodiments of the system 10 comprise a piston 22 and cylinder 24 device 12 having a self-contained power source for the generation of a reduced pressure and for aspirating the site 18.
12/04/14
20140357991
Xerostomia markers
Certain embodiments of the present invention provide methods of determining an efficacy of a xerostomia treatment in a mammalian subject (e.g., a human) that include the steps of comparing a first thickness of a site in the subject that comprised of sub-epithelial oral mucosa to a second thickness of the site; and thereby determining that: the xerostomia treatment is efficacious because the second thickness is greater than the first thickness; or the xerostomia treatment is not efficacious because the first thickness is greater than or equal to the second thickness. In such methods, assaying the first thickness comprises analyzing a first oct scan of the site that was conducted at a time close to the subject starting the xerostomia treatment, and assaying the second thickness comprises analyzing a second oct scan of the site that was conducted at a time close to the subject completing the xerostomia treatment..
12/04/14
20140357671
Spot-on pesticide composition
A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises fipronil, etofenprox, and an insect growth regulator as the active components, in doses and proportions which are effective against a variety of insects and pests, and in a formulation which is convenient for local application to the animal's skin, preferably localized over a small surface area.. .
12/04/14
20140357654
Methods of treating schizophrenia with phenylalanine enamide derivative inhibitors of a4 integrin possessing a cyclobutene group
Embodiments of the invention relate to the treatment of schizophrenia in mammals. Embodiments of the invention include methods for treating schizophrenia and/or symptoms of schizophrenia and/or a positive symptom of schizophrenia in a psychotic disease as well as methods for preparing medicaments used in the treatment of mammalian schizophrenia.
12/04/14
20140357610
Composition and method for affecting obesity and related conditions
A method of reducing caloric intake or food intake in a mammal in need thereof. The method including delivering an effective amount of a compound comprising manganese [iii] tetrakis (4-benzoic acid) porphyrin (mntbap) or analogs thereof to a mammal over a period of time sufficient to induce a reduction in caloric intake or food intake of the mammal..
12/04/14
20140357609
Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues
Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component that includes an glucocorticoid derivative which, upon delivery to the posterior segment of a mammalian eye, does not significantly diffuse to the anterior segment of said eye. Methods of making and using the present materials are also described..
12/04/14
20140357602
Combination therapies for treating metabolic disorders
This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier.
12/04/14
20140357568
Method of increasing muscle mass and strength and compositions therefor
A method of increasing muscle mass and strength in mammals by orally administering a therapeutically effective amount of phosphatidic acid. The phosphatidic acid is preferably administered as a plurality of doses per day with at least one dose being administered during the anabolic window following exercise.
12/04/14
20140357561
Natriuretic polypeptide delivery systems
This document provides natriuretic polypeptide delivery systems. For example, methods and materials related to natriuretic polypeptide delivery systems, methods and materials related to the use of such delivery systems to deliver natriuretic polypeptides to a mammal over a pro-longed period of time (e.g., weeks to months), and methods and materials related to treating heart failure conditions are provided..
12/04/14
20140356950
Methods of deriving mammalian pluripotent stem cell lines
A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.. .
12/04/14
20140356945
Potential regenerative cell and its culturing method
The present invention relates to a type of cell—potential regenerative cell (prc) capable of continuous proliferation, and generated mammal (including human) cells, tissues and tissue-organs by in vitro culture and replication of prcs. The present invention also relates to the methods and cell growth regulators for culturing mammal (including human) prcs, tissues, and tissue-organs..
12/04/14
20140356910
Methods for increasing mannose content of recombinant proteins
The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.. .
12/04/14
20140356908
Binding molecules
A transgenic non-human mammal containing a heterologous heavy chain gene locus that is capable of producing soluble heavy chain only antibodies and antigen-binding fragments thereof following immunization.. .
12/04/14
20140356907
Antibody production
A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in b-cells following antigen challenge.. .
12/04/14
20140356905
Mammalian cell culture system for large-scale expression of recombinant proteins
Compositions and methods for large-scale recombinant protein expression are disclosed.. .
12/04/14
20140356466
Method for treating pain and inflammation associated with arthritis using chromium-three cation in combination with phyllanthus emblica and shilajit
Chromium-three cation in combination with phyllanthus emblica extract and shilajit is useful in treating symptoms associated with osteoarthritis including reduction of inflammation and pain in a mammal, particularly a human or an animal. The combination shows significant reduction in overall pain levels and other pain measures in a canine model, and in human studies.
12/04/14
20140356395
Methods and materials for producing immune responses against polypeptides involved in antibiotic resistance
This document relates to methods and materials for producing immune responses against polypeptides involved in antibiotic resistance. For example, vaccines against polypeptides involved in antibiotic resistance as well as methods for vaccinating mammals against polypeptides involved in antibiotic resistance are provided..
12/04/14
20140356335
Mammalian fetal pulmonary cells and therapeutic use of same
A pharmaceutical composition comprising as an active ingredient an isolated population of cell suspension from a mammalian fetal pulmonary tissue is disclosed. The fetal pulmonary tissue is at a developmental stage corresponding to that of a human pulmonary organ/tissue at a gestational stage selected from a range of about 20 to about 22 weeks of gestation.
12/04/14
20140356331
Injectable cns-derived ecm for tissue reconstruction
Methods useful for preparing central nervous system (cns) derived extracellular matrix (ecm) materials, including powders and gels are provided. Also provided are cns ecm preparations prepared according to those methods, and methods of treating a patient or mammal with cns injury..
12/04/14
20140352699
Extremity surgical support debridement platform
The present invention provides a surgical support debridement platform for extremities of a human or mammal to assist a physician in treating such extremity. The platform generally includes a body member.
11/27/14
20140350645
Altering temperature in a mammalian body
The present application relates to systems and methods for altering temperature in a mammalian body. Optionally, the systems and methods can be used to lower or raise core body temperature of a mammalian subject.
11/27/14
20140350444
Device and method for applying pressure to a mammalian limb
A therapeutic pressure strap for applying pressure across a muscle or muscle groups on a mammalian limb is described. The strap is particularly well suited for treating “tennis elbow”.
11/27/14
20140350363
Measuring chamber for an optical sensor for determining a concentration of a substance in the tissue fluid of a mammal
A measuring chamber device for an optically operating sensor for determining a concentration of a substance that is contained in tissue fluid of a mammal. The measuring chamber device has a measuring chamber filled with a liquid measuring medium and a wall with better diffusion permeability for the substance than for other constituents of the tissue fluid.
11/27/14
20140350079
Small interference rnas, uses thereof and method for inhibiting the expression of plk1 gene
The present invention provides sirnas for inhibiting the expression of plk1 gene, and the method for inhibiting the expression of plk1 gene in mammalian cells. The sirnas of the present invention have the double-stranded structure, and said double-stranded structure is composed of the first single strand and the second single strand that are fully complementary, wherein the sequence of said first single strand is the same as the target sequence within the sequence as shown in seq id no: 1, and the sequence of said second single strand is complementary to the target sequence within the sequence as shown in seq id no: 1.
11/27/14
20140350072
Novel repressor on ifn-lambda promoter and sirna against zeb1 and blimp-1 to increase ifn-lambda gene activity
The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the ifn-λ1 promoter. The present invention provides a method of using sirnas against zeb1 (binds to the repressor region) and blimp-1 (binds outside the repressor region) and increases the promoter activity of ifn-λ1 (i.e., increases the production of ifn-λ1 protein).
11/27/14
20140350024
Antimicrobial agents
The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula i: wherein two of x1 to x8 are n and the remaining of x1 to x8 are ch; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula i and salts thereof and pharmaceutical compositions comprising a compound of formula i or a pharmaceutically acceptable salt thereof.. .
11/27/14
20140349987
Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rory, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases
The invention provides modulators for the orphan nuclear receptor rorγ and methods for treating rorγ mediated diseases by administrating these novel rorγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of formula (1) and the enantiomers, diastereomers, n-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof..
11/27/14
20140349955
Use of fluorine-containing water soluble platinum complex in preparing drugs for prevention and treatment of cancers
Disclosed in the present invention is the use of a fluorine-containing in preparing drugs for the prevention and treatment of tumors, said platinum complex being shown as formula (i). Experiments have demonstrated that the present fluorine-containing water soluble platinum complex is highly water soluble and exhibiting superior cytotoxicity and efficacy compare to the clinical platinum drugs.
11/27/14
20140349942
Methods for reducing oxidative damage
The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide.
11/27/14
20140349884
Synthetic mammalian neuromuscular junction and method of making
A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium.
11/27/14
20140349401
Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (ipscs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells.
11/27/14
20140349390
In vivo delivery of nucleic acids to the liver or liver tissue
The invention encompasses methods of delivering nucleic acids, including dsrna, to mammalian target cells in vivo via intercellular transfer, wherein the dsrna is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsrna to the target cell.. .
11/27/14
20140348975
Mimicking the metabolic effect of caloric restrictions by administration of glucose anti-metabolites to enhance positive response in a mammal
The present invention relates to a use of composition comprising a glucose anti-metabolite and/or source of glucose anti-metabolite in a method of enhancing a positive affect and/or energetic arousal in a mammal.. .
11/27/14
20140348916
Treatment of pain with oral dosage forms comprising zoledronic acid and an enhancer
Disclosed herein are methods of treating or preventing pain. Typically, a pharmaceutical composition having a therapeutically effective amount of the zoledronic acid is administered to a mammal suffering from pain.
11/27/14
20140348882
In vivo delivery of nucleic acids to the liver or liver tissue
The invention encompasses methods of delivering nucleic acids, including dsrna, to mammalian target cells in vivo via intercellular transfer, wherein the dsrna is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsrna to the target cell.. .
11/27/14
20140348813
Thermostabilization of proteins
Provided are compositions comprising a cocaine esterase (coce) and a compound that thermostabilizes the coce. Also provided are methods of thermostabilizing a cocaine esterase.
11/27/14
20140348808
Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
The present invention relates to immunomodulatory cells, methods for providing immunomodulatory cells, and therapeutic uses of the cells for the immune modulation of mammals in need thereof.. .
11/27/14
20140348806
Cell-based therapy for the pulmonary system
Cell based therapy comprises administration to the lung by injection into the blood system of viable, mammalian cells effective for alleviating or inhibiting pulmonary disorders. The cells may express a therapeutic transgene or the cells may be therapeutic in their own right by inducing regenerative effects..
11/27/14
20140348804
Agent derived from tortoise spleen stimulating mammalian hemopoiesis
The present invention relates to a proteinaceous extract derived from tortoise spleen and to a tetrapeptide ftgn, which have stimulatory activity on hematopoietic cells. In particular, this tetrapeptide enhances hemopoietic reconstruction, and bone marrow re-population, reduced as a consequence of a high dose of radiation or chemotherapy exposure.
11/27/14
20140348793
Method of treatment
The present invention relates generally to a method of regenerating the hippocampus in a mammal and agents for use therein. More particularly, the present invention provides a method of regenerating the hippocampus in a mammal by administering a sub-population of neural crest stem cells.
11/27/14
20140348792
Methods to reduce polyposis and colorectal cancer
Methods for reducing or inhibiting polyposis or colorectal cancer are provided. The methods comprise administering to a mammal a bacterium modified to decrease the display of lipoteichoic acid on the cell surface.
11/27/14
20140348791
Modified adenoviral vectors and methods of treatment using same
The present invention relates to recombinant adenovirus serotype 5 (ad5) vectors which harbor chimeric capsid proteins including substitutions of the corresponding regions from adenovirus serotypes having a lower seroprevalence relative to ad5. In particular, the chimeric capsid includes modifications of both the adenoviral hexon and fiber proteins.
11/27/14
20140348762
Diagnostic methods
Described herein are methods for identifying a mammal having a heightened susceptibility to enamel erosion, together with kits therefor and uses and methods related thereto.. .
11/27/14
20140348752
Methods for treating lysosomal acid lipase deficiency in patients
The present invention provides methods of treating lal deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing lal tissue concentration, and increasing lal activity in a human patient suffering from lal deficiency are also provided..
11/20/14
20140343673
Extracellular matrix encasement structures and methods
A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region and at least one lead conduit, the internal region being configured to receive a device therein, the lead conduit being configures to receive at least one device lead therein, the bioremodelable material comprising an extracellular matrix (ecm) composition that includes an ecm component derived from a mammalian source.. .
11/20/14
20140343452
Pseudobezoar-based intraluminal gastrointestinal cleansing and biospy
The present disclosure describes an orally administrable implement comprising expandable material designed specifically to swell in a targeted gastrointestinal (gl) organ of a mammal, including human to form a pseudobezoar, so that upon swelling it touches the walls of the targeted organ. In one design, the swollen pseudobezoar provides sponge-like cleansing of the targeted gl organ to prepare the said organ for further examination.
11/20/14
20140343413
Formulation of solid nano-sized particles in a gel-forming system
The present invention relates to novel formulations comprising a plurality of nano-sized solid particles and a gel-forming system, useful, e.g. For imaging of the body of a mammal.
11/20/14
20140343389
Wireless monitoring device
The present invention relates to a monitor and monitoring system suitable for attachment to the skin of a mammal, including a human. The monitor and monitoring system are designed for continuous wireless real-time measurement of physiological signals and transmission of the measurements to a remote computer or mobile device..
11/20/14
20140343256
Tlr2 antagonistic antibody and use thereof
The present invention is directed to a cross-reactive antibody, which specifically inhibits or blocks the mammalian toll-like receptor 2 (tlr2)-mediated immune cell activation. The invention is further directed to an isolated nucleic acid or vector coding for the variable regions of the heavy and/or light chain of said antibody.
11/20/14
20140343252
Interleukin-2 muteins for the expansion of t-regulatory cells
Provided herein are il-2 muteins and il-2 mutein fc-fusion molecules that preferentially expand and activate t regulatory cells and are amenable to large scale production. Also provided herein are variant human igg1 fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at n297.
11/20/14
20140343147
Nutritional supplement for the enhancement of muscle performance and recovery and methods of use thereof
Described herein are nutritional supplements containing α-hydroxy-isocaproic acid and aspartic acid (e.g., daa) and their methods of use in enhancing muscle performance and/or recovery after exercise. The nutritional supplements can be used to enhance muscle building and lean body mass, enhance muscle and physical performance, enhance recovery, and prevent catabolism (muscle atrophy or wasting) when administered to a mammalian subject..
11/20/14
20140343129
Modified nucleic acids, and acute care uses thereof
The invention provides compositions and methods for effecting wound healing in a mammal, where the compositions include therapeutic mrna which incorporate modified nucleosides and nucleotides.. .
11/20/14
20140343059
Novel piperazines, pharmaceutical compositions and methods of use thereof
Disclosed are novel piperazine derivatives that act as agonists of the α7 nachr. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating cns disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds..


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