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Mammal

Mammal-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Method of monitoring the status of a wound
February 15, 2018 - N°20180047162

A system for determining a clinically relevant temperature differential between a predetermined area of interest on the body surface of a mammal and a control area on the body surface of said mammal, said system comprising: a visual and thermal image capturing device, said image capturing device comprising: a housing, a means for capturing a digital visual image within said ...
NEW Use of phenolic antioxidants in cell culture for the production of proteins
Bristol-myers Squibb Company
February 15, 2018 - N°20180044709

The present invention relates to new methods and processes for culturing mammalian cells with the addition of phenolic antioxidants. Performance of the cell culturing methods and processes in their various aspects result in a higher viable cell density and higher protein titer.
NEW Methods for growing cells
Children's Hospital Medical Center
February 15, 2018 - N°20180044637

Some embodiments of the invention include methods for growing stem cells comprising growing the stem cells in a cell medium. In certain embodiments, the cell medium has a ph of from about 6. 6 to about 7. 2. Other embodiments of the invention embodiments include methods for transplanting comprising (a) growing first stem cells in a cell medium having a ph of from about 6. 6 ...
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NEW Minimally-invasive and activity-dependent control of excitable cells
Central Michigan University
February 15, 2018 - N°20180044397

The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of the invention can be used to desynchronize local activity of excitable cells in a mammalian ...
NEW Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells
February 15, 2018 - N°20180044392

The present invention further provides expression vectors, and il-15 and il-15 receptor alpha combinations (nucleic acid and protein) that increase il-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of il-15 after dna, rna or protein administration in a subject (e. G. A mammal, a human).
NEW Nucleoside phosphoramidates
Gilead Pharmasset Llc
February 15, 2018 - N°20180044367

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of rna-dependent 5 rna viral replication and are useful as inhibitors of hcv ns5b polymerase, as inhibitors of hcv replication and for treatment of hepatitis c infection in mammals.
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NEW 4-substituted benzoxaborole compounds and uses thereof
Anacor Pharmaceuticals, Inc.
February 15, 2018 - N°20180044353

Substituted benzoxaboroles whose structure comprises formula (iii), wherein r3 is selected from —ch3, —ch2ch3, —ch2═ch2, —ch2ch2ch3, —ch(ch3)2, —ch2ch2═ch2, and cyclopropyl, r1 and r2 are each independently selected from h, —ch3, —ch2ch3, —ch2ch2ch3, and —ch(ch3)2; compositions containing such ...
NEW Compositions comprising an inhibitor of lysine specific demethylase-1
Celgene Quanticel Research, Inc.
February 15, 2018 - N°20180044320

Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the lysine specific demethylase-1 inhibitor 4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile. Also described are pharmaceutical compositions suitable for administration to a mammal that include the lysine specific demethylase-1 inhibitor, and methods of using the lysine specific demethylase-1 inhibitor for ...
NEW Cellular component concentrator and filter apparatus
Arthrex, Inc.
February 15, 2018 - N°20180043375

The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.
NEW Cross-linked fatty acid-based biomaterials
Atrium Medical Corporation
February 15, 2018 - N°20180043065

Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using ...
NEW Rp2 and rpgr vectors for treating x-linked retinitis pigmentosa
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
February 15, 2018 - N°20180043035

Disclosed are adeno-associated virus (aav) vectors comprising a nucleotide sequence encoding rp2 or rpgr-orf15 and related pharmaceutical compositions. Also disclosed are methods of treating or preventing x-linked retinitis pigmentosa, increasing photoreceptor number in a retina of a mammal, and increasing visual acuity of a mammal using the vectors and pharmaceutical compositions.
NEW Treatment of eye disease
Oxford University Innovation Limited
February 15, 2018 - N°20180042992

A method of treating an eye disease comprising administering an adeno-associated virus (aav) vector to a mammalian subject by subretinal injection, wherein the aav vector comprises a nucleotide sequence encoding melanopsin operably linked to an expression control sequence to promote expression of melanopsin in cells of the eye of the subject.
NEW Recombinant glut1 adeno-associated viral vector constructs and related methods for restoring glut1 expression
University Of Massachusetts
February 15, 2018 - N°20180042991

The present invention relates to recombinant glut1 adeno-associated viral vector (raav) constructs and related methods for restoring glut1 expression in glut1 deficient mammals. In certain embodiments, the raav further comprises a chicken β-actin promoter wherein the raav is capable of crossing the blood-brain barrier (bbb). In certain embodiments, the present invention relates to a composition comprising any of ...
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NEW Vascular calcification prevention and treatment
Summit Innovation Labs Llc
February 15, 2018 - N°20180042962

The invention encompasses compositions and methods for effectively interfering, reducing and preventing conversion of vascular smooth muscle cells (vsmcs) and circulating stem cells to osteoblastic bone-like cells, thereby reducing and/or preventing vascular calcification (vc) or calcium mineral (hydroxyapatite) deposition in the vasculature. The severity and extent of calcification in the major arteries reflect atherosclerotic plaque burden and strongly predict ...
NEW Glucocerebroside treatment of disease
Enzo Therapeutics, Inc.
February 15, 2018 - N°20180042959

The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects. This method comprises the administration of a naturally occurring, mammalian intermediary metabolite or t cell receptor ligand, preferably a glucosylceramide, to a mammalian subject. In a preferred embodiment, such mammalian subjects are human ...
NEW Glucocerebroside treatment of liver disorders
Enzo Therapeutics, Inc.
February 15, 2018 - N°20180042951

The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects. This method comprises the administration of a naturally occurring, mammalian intermediary metabolite or t cell receptor ligand, preferably a glucosylceramide, to a mammalian subject. In a preferred embodiment, such mammalian subjects are human ...
NEW Use of cysteamine and derivatives thereof to suppress tumor metastases
Meshaberase, Llc
February 15, 2018 - N°20180042870

The present disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e. G., cysteamine or cystamine or derivatives thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.
NEW Buffered microencapsulated compositions and methods
Premier Dental Products Company
February 15, 2018 - N°20180042826

A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
NEW Portable, durable, rugged, functional near-infrared spectroscopy (fnirs) sensor
Charles River Analytics, Inc.
February 15, 2018 - N°20180042484

A functional near-infrared spectroscopy sensor may include: a pliable substrate; a near infrared led embedded in the pliable substrate; a red led embedded in the pliable substrate; an optical detector embedded in the pliable substrate; a data storage device that receives and stores information derived from the optical detector and that is configured to attach to a head of a ...
Methods for the identification, assessment, prevention, and treatment of neurological disorders and diseases
Wake Forest University
February 08, 2018 - N°20180038875

Described herein are methods of identifying a mammal having a neurological disease or disorder, such as ad or mci, or at risk for developing a neurological disease or disorder, such as ad or mci. Provided herein are also methods of monitoring the progression of a neurological disease or disorder in a patient or monitoring the effectiveness of therapeutic agent or ...
Nanofluidic device for isolating, growing, and characterizing microbial cells
Northeastern University
February 08, 2018 - N°20180037924

Nanofluidic devices and methods of the invention are capable of autonomously isolating individual microbial cells using constrictive channels and growing monocultures of the cells for automated characterization of their biochemical properties and interactions with mammalian cells. Single microbial cells, such as bacterial cells, are isolated directly from environmental sources and cultured using chemical factors from their native environment.
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