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Mammal patents

      

This page is updated frequently with new Mammal-related patent applications.




new patent Biomarkers for assessing kidney diseases
The present invention relates to a metabolic biomarker set for assessing kidney disease comprising at least two amino acids, at least two acylcarnitines and at least two biogenic amines. Moreover, the present invention relates to a method for assessing kidney disease in a mammalian subject which comprises obtaining a biological sample, preferably blood and/or urine, from the subject and measuring in the biological sample the amount of at least two amino acids, of at least two acylcarnitines and of at least two biogenic amines, as well as to a kit adapted to carry out the method.
Biocrates Life Sciences Ag


new patent Kit for monitoring, detecting and staging gvhd
D. Administering an effective amount of at least one immunosuppressant or steroid or a combination thereof to the diagnosed mammal..

new patent Device for detecting misfolded proteins and methods of use thereof
The present invention relates to diagnostic devices as well as methods of using these devices for detecting proteins of interest associated with diseases or disorders in mammals. In particular, the proteins of interest may be misfolded proteins associated with certain misfolded-protein disorders in mammals including those mammals suspected of or at risk of having such disorders..
Gestvision, Inc.


new patent A screening method, a kit, a treatment and a compound for use in a treatment
A method to identify a candidate compound for use in the treatment of a condition involving dysregulation of glucose homeostasis or of glucose uptake in a mammal, by identifying a candidate compound that causes an increase in translocation of glut without causing an increase in the production of camp. A kit for use in such a method.
Atrogi Ab


new patent Asymmetric interfering rna compositions that silence k-ras and methods of uses thereof
The invention provides novel compositions for use in silencing k-ras gene expression. More particularly, the invention provides novel asymmetrical interfering rna molecules as inhibitors of k-ras expression, and to pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal..
Boston Biomedical, Inc.


new patent Methods for in vivo genome editing
Methods of transfecting cells in vivo, by administering an injectable pharmaceutical composition including a genome editing composition and a pharmaceutically acceptable carrier to a subject by hydrodynamic injection into a vessel of the subject are disclosed. Typically, the pharmaceutical composition is administered in a volume and at rate of injection suitable to transfect target eukaryotic cells in the subject with an effective amount of the genome editing composition to alter the genome of the target cells.
Massachusetts Institute Of Technology


new patent Stabilized anti-microbial peptides
The present invention provides methods of designing and making structurally stabilized anti-microbial peptides for the prophylaxis and treatment of infection. Methods are also disclosed for designing stabilized anti-microbial peptides that are selectively lytic/cytotoxic to bacteria, allowing for internal use of anti-microbial peptides without mammalian membrane disruption and cytotoxicity..
Dana-farber Cancer Institute, Inc.


new patent Materials and methods for producing cleaved, hiv-1 envelop glycoprotein trimers
Expression vectors and mammalian cell lines containing them are described that enable the recombinant production of hiv-1 envelope proteins, including sosip modified gp140 trimers capable of inducing broadly neutralizing antibodies.. .
Cornell University


new patent Pyrimidine derivatives
Or pharmaceutically acceptable salts thereof, wherein x, y, z, r1-r11, m, n, and p are defined herein. The novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals.

new patent Platelet-derived growth factor compositions and methods of use thereof
A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/ml to about 1.0 mg/ml in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.. .
Biomimetic Therapeutics, Llc


new patent

Conjugates of cysteine engineered antibodies

The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (cba) is covalently linked to the cytotoxic agent through an engineered cys, such as an engineered cys in the heavy chain ch3 domain, at a position corresponds to the eu/ou numbering position 442 (or c442) on an antibody cba. The invention also provides methods of preparing the conjugates of the present invention.
Immunogen, Inc.

new patent

Oligosaccharides comprising an aminooxy group and conjugates thereof

The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates.
Genzyme Corporation

new patent

Implantable polymeric device for sustained release of sufentanil

Extended release of sufentanil is provided by implanting a device containing sufentanil into a mammal or human being. The device may include a solid biocompatible polymer matrix, and sufentanil may be encapsulated within the polymer matrix.
Antecip Bioventures Ii Llc

new patent

Stabilized hypohalous acid solutions

The present invention provides a stabilized hypohalous acid solution (or formulation thereof), which may be conveniently packaged for sale, or stored for later use on demand. The invention further provides methods of making the stabilized hypohalous acid solution, as well as methods of use for disinfecting mammalian tissue, including wounds and burns, disinfecting or cleansing surfaces, or treating and/or preserving food products and cut flowers, among other uses..
Puricore, Inc.

new patent

Vaccine compositions

The present disclosure provides vaccine compositions for prophylaxis and treatment of zika virus infections comprising zika virus antigens in immunogenic compositions, and in combination of zika antigens with one or more arbovirus antigens such as chikungunya virus and japanese encephalitis virus antigens, methods of preparation and production of such compositions for use as vaccines for eliciting immune response in mammals against the above mentioned pathogens.. .
Bharat Biotech International Limited

new patent

Novel treatment method

There is provided according to the invention a method of treating a mammal suffering from or susceptible to an immune reaction to drug treatment comprising the raising of anti-drug antibodies which method comprises (a) ex-vivo treating antigen presenting cells obtained from the mammal with an agent which induces ido in said antigen presenting cells in the presence of said drug or an epitope containing fragment thereof and (b) after ido has been induced in said antigen presenting cells, transferring said cells back to the mammal thereby to establish immune tolerance to the drug.. .
Idogen Ab

new patent

Prostate cancer vaccine

Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer.
Wisconsin Alumni Research Foundation

new patent

Methods and materials for reducing the severity of viral infections

This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods and materials for reducing the severity of a viral infection present in a mammal (e.g., a human) are provided..
Mayo Foundation For Medical Education And Research

new patent

Methods of treating or preventing pruritis by blocking natriuretic polypeptide b

Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits nppb activity is also disclosed..
The United States Of America, As Represented By The Secretary , Department Of Health & Human Servi

new patent

Platelet-derived growth factor compositions and methods of use thereof

A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/ml to about 1.0 mg/ml in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.. .
Biomimetic Therapeutics, Llc

new patent

Platelet-derived growth factor compositions and methods of use thereof

A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/ml to about 1.0 mg/ml in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.. .
Biomimetic Therapeutics, Llc

new patent

Attenuation of intrapulmonary inflammation

Wherein x1 comprises an amino acid (sequence) with 1 to 4, in particular 1 to 3 members, comprising natural or unnatural amino acids, in particular selected from the amino acid (sequence) c, ksp, k, ornithin, 4-amino butanoic acid, β-alanine, and x2 comprises one amino acid, selected from natural amino acids, in particular selected from the group c, d, g and e, and wherein x1 comprises the n-terminal amino acid at ist first left position and x2 comprises the c-terminal amino acid at its last right position, optionally in the form of a salt for use in the treatment of inflammation, a pharmaceutical composition for treating inflammation comprising such compound and a method of treating inflammation comprising administering an effective amount of such compound to a mammal in need thereof.. .

new patent

Inducing brown fat fate and function

Methods and compositions are described herein for generating brown adipose cells and tissues that involve contacting one or more starting cells with bexarotene, ciclopirox, iox2, or combinations thereof. When administered in vivo, subjects receiving bexarotene, ciclopirox, iox2, or combinations thereof have reduced white adipose tissue mass (with enhanced beige features) as well as enlarged brown fat tissue compared to a control mammal that did not receive the bexarotene, ciclopirox, iox2, or combinations thereof.
The J. David Gladstone Instiutes, A Testamentary Trust Established Under The Will Of J. David Glads

new patent

Compositions and methods for reducing chronic low-level inflammation

The invention relates to compositions and methods for reducing chronic low-level inflammation associated with chronic conditions. Specifically, the invention relates to compositions of hydrophobic derivatives of aspirin and/or hydrophobic derivatives of sesamol in combination with eicosapentaenoic acid (epa) and docosahexaenoic acid (dha), and their methods for reducing chronic low-level inflammation associated with chronic conditions including obesity, metabolic syndrome, diabetes, cardiovascular disease, cancer, auto-immune disorders, ocular and neurological disorders in a mammal..

new patent

Devices, systems, and kits for regulating skin temperature for mammals

A heat transfer system may include a heat transfer machine adapted to thermally couple to an heat transfer pack housed within an heat transfer device and transfer heat from the heat transfer pack using a power supply. The heat transfer device may include a housing and a heat transfer pack.
Slumber Science Llc

new patent

Renal function analysis method and apparatus

A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject.
Pharmacophotonics, Inc. D/b/a Fast Biomedical

new patent

Use of erythritol or compositions comprising same as mammal-safe insecticides

The invention includes a mammal-safe method of killing or harming an insect. The method comprises administering to the insect a composition comprising erythritol ((2r,3s)-butane-1,2,3,4-tetraol)..
Drexel University

new patent

Portable organ perfusion system

A profusion system for a mammalian organ comprising a first and a second pump to propel perfusion fluid through one of a closed fluid circuit system and a selectively closeable fluid circuit system that includes an organ artery and an organ vein, a filter cartridge bank consisting of a plurality of filtration cartridges, and a first and a second fluid reservoir.. .
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

Method of detecting boundaries of the human eye

A method of generating a reliable image of an iris for subsequent optical analysis leading to identification or authentication of a mammal. The method comprises directing point light sources towards the iris, capturing a gray scale image of the iris and reflections of the point light sources, deriving a two tone image from the gray scale image, generating an image containing the true boundaries of the pupil, determining boundaries of the iris and generating an image containing the true boundaries of the iris, and generating a final image of the iris from the image containing the true boundaries of the iris.

Guided differentiation of induced pluripotent stem cells

This document provides methods and materials related to making and using differentiated induced pluripotent stem cells. For example, methods and materials for making differentiated induced pluripotent stem cells (e.g., insulin-producing cells) that do not form cancer cells within a mammal (e.g., a human), cells that underwent guided differentiation from induced pluripotent stem cells, compositions containing cells that underwent guided differentiation from induced pluripotent stem cells, and methods for using cells that underwent guided differentiation from induced pluripotent stem cells (e.g., methods for using such cells to treat diabetes or to repair cardiovascular tissue) are provided..
Mayo Foundation For Medical Education And Research

Mammalian metabolites of steroids

Described herein, in certain embodiments, are steroidal derivatives, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat androgen receptor mediated diseases or conditions.. .
Tokai Pharmaceuticals, Inc.

Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry

This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tscs) to the mammal at a frequency and intensity that induces the desired locomotor activity..
The Regents Of The University Of California

Implantable chamber for collection and supply of interstitial fluid

A system for redistributing interstitial fluid within a mammal is disclosed. The system comprises an implantable accumulation chamber, a confined flow passageway such as a catheter in communication with the accumulation chamber, and a liquid transfer pump for dispensing accumulated interstitial fluid from the accumulation chamber to a predetermined body site via the confined flow passageway..

Hemostatic compositions and methods

Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings, particularly for the treatment of injured tissue via endoscopic or minimally-invasive surgical techniques..
Stb, Ltd.

Methods and compositions for gene delivery to on bipolar cells

Disclosed are capsid-modified raav expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using novel capsid-protein-mutated raav vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more diseases, disorders, or dysfunctions of the mammalian eye.
University Of Florida Research Foundation, Inc.

Methods and compositions used in treating inflammatory and autoimmune diseases

Methods of treating neuroinflammation by administration of a selective protein c activator, such as recombinant human we thrombin and optionally one or more of its cofactors are disclosed. Also disclosed are pharmaceutical compositions for use in the treatment of mammals that exhibit symptoms of neurological inflammation.
The United States Government As Represented By The Department Of Veterans Affairs

Pharmaceutical composition for cancer treatment and pharmaceutical preparation for cancer treatment containing same composition as active ingredient

The invention provides a novel anticancer therapeutic having a high effect against solid cancers, lacking the side effects of chemotherapeutics, and being unlikely to cause resistance. Provided is a pharmaceutical composition for cancer treatment prepared by a method having: a stem cell production step for making immortalized stem cells by introducing four types of genes into deciduous tooth dental pulp stem cells obtained from the dental pulp of mammals; and a condition medium preparation step for culturing the immortalized stem cells for a predetermined length of time in serum-free medium at 23-27° c.
Quarrymen Corporation

A treating neoplasia

The present invention relates to a method of treating a neoplastic condition in a mammal. More particularly, the present invention is directed to a method of treating solid tumours, such as primary tumours, secondary tumours, and metastatic tumours.
Fuwan Pty Ltd.

Novel sulfonamide compounds for inhibition of metastatic tumor growth

Are disclosed, which compounds selectively inhibit caix and caxii, and which are effective to inhibit hypoxic tumor growth, suppress metastases, and impair and deplete cancer stem cells in mammals.. .

Method of replenishing steroid hormones in neutered mammals comprising administration of dehydroepiandrosterone (dhea) and specific metabolites in order to increase steroid hormone levels from those of neutered mammals associated with high cancer risk, to steroid hormone levels of gonadally-intact mammals associated with reduced cancer risk, without inducing the side effects that would occur without metabolite supplementation.

The low steroid hormone levels of neutered or aging mammals is associated with a dramatic increase in risk of cancer. This invention pertains to a natural method of replenishing the low steroid hormone levels of neutered or aging mammals, levels that are associated with high cancer risk, to levels of those of non-neutered or young animals, levels that are associated with a low cancer risk.

Use of fk506 for the treatment of pulmonary arterial hypertension

A method for reducing pulmonary hypertension in a mammal that employs fk506 is provided. In certain embodiments, the method comprises administering fk506 to a mammal having pulmonary arterial hypertension associated with defective mbpr2 signaling at a dosage sufficient to reduce blood pressure in the pulmonary artery of the mammal..
The Board Of Trustees Of The Leland Stanford Junior University

Use of dipeptidyl peptidase iv effectors for normalizing the blood glucose level in mammals

The invention further comprises the use of activity-reducing effectors of dipeptidyl peptidase (dp iv) and dp iv-analogous enzyme activity in the blood of a mammal to increase the half-life of incretins in vivo.. .

Method of treating or inhibiting the development of brain inflammation and sepsis

A leukotriene c4 and d4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white blood cell extravasation. Potential candidate compounds can be screened in a non-human mammal before or after administration of an inflammation inducing agent into the subarachnoid space by determining their ability to inhibit increased capillary permeability and white blood cell extravasation..
Inflammation Research Center Company Ltd.

Method and device for measuring the position of an eye

A device for measuring the position of an eye of a mammal. To determine a positional change of the eye between two time points, the device comprises: at least one optical coherence tomograph for generating images of at least a part of the retina at the two time points and for emitting corresponding image data and an image processing device which is designed to compare the image data assigned to the two time points and to determine an angle of rotation between the images, wherein the image processing device is additionally designed to output the angle of rotation as information about a cyclotorsion of the eye between the two time points..
Carl Zeiss Meditec Ag

Apparatus, system, and measuring lymphatic pressure and performance in vivo

Methods for measuring lymphatic performance are provided herein. Lymphatic pressure is measured by introducing a near infrared flourophore into the limb of a mammal, detecting the lymph flow with near infrared lights and sensors, occluding lymph flow with a pressure cuff, and then noting the pressure at which lymph flow returns.
Georgia Tech Research Corporation

Probiotics for use in expecting female mammals for enhancing the immunity of their offspring

The present invention relates to the use of probiotic on expecting female mammals to boost the immune status of an offspring. The use can induce an enhanced response of the offspring after birth to an infectious antigenic exposure.
Nestec S.a.

Methods of identifying insect-trpa1 modulators

The invention provides a screening method for identifying an insect-specific trpa1 modulator by comparing modulation of an insect trpa1 and a mammalian trpa1. The invention further provides method of insect control by applying to an insect a insect-specific trpa1 modulator identified by the screening method..
Brandeis University

Detecting podocyte injury in diabetic nephropathy and glomerulonephritis

This document provides methods and materials involved in determining whether or not a mammal with diabetic nephropathy or glomerulonephritis is undergoing podocyte injury. For example, methods and materials related to the use of urinary microvesicles to determine whether or not a mammal with diabetic nephropathy or glomerulonephritis is undergoing podocyte injury are provided..
Mayo Foundation For Medical Education And Research

Biological characterization of a glatiramer acetate related drug product using mammalian and human cells

Thereby characterizing the glatiramer acetate related drug substance or drug product of step a).. .

Novel methods of identifying patients responsive to immunotherapeutic strategies

The invention includes a method of determining whether a mammal's cancerous tumor is associated with a hypermutator phenotype (i.e., harboring a large number of mutations) for the dna polymerase epsilon (pole) gene as compared to normal cells. The invention further includes a method of selecting patients harboring an immunogenic tumor that is responsive to immunotherapy..
Yale University

Compositions and methods for antibody production

Compositions and methods for minimizing antibody disulfide bond reduction are described. In one aspect, a composition is provided for culturing mammalian host cells to express an antibody including an anti-reduction agent that minimizes reduction of a disulfide bond in the antibody or fragment thereof.
Immunogen, Inc.

Medium for the protein-free and serum-free cultivation of cells

A medium is described for the protein-free and serum-free cultivation of cells, especially mammalian cells, whereby the medium contains a proportion of soy hydrolysate.. .
Baxalta Innovations Gmbh

Compositions and methods for detecting and modulating cell death by a translation regulated gene expression system

The technology relates to a nucleic acid expression cassette comprising a tr element encoding an mrna molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably linked to the tr element, that is a first open reading frame (orf) sequence and encodes a polypeptide or a fragment thereof and is co-translated with the tr element. The technology further relates to mammalian cells and a transgenic animal comprising such expression cassette.
Wayne State University

Composition for reducing cellular senescence level including activity inhibitor inhibiting dcun1d3 activity or expression inhibitor inhibiting expression of dcun1d3-encoding gene and use thereof

Provided is a composition and method for reducing a cellular senescence level by inhibiting the activity or expression of one or more of dcun1d3 protein or gene encoding same and a polynucleotide having a nucleotide sequence of seq id no: 5, as well as a method of treating a disease or a disease symptom associated with an increased cellular senescence level in a mammal.. .
Samsung Electronics Co., Ltd.

Cgap-pna multivalent peptide nucleic acid ligand display

Described herein are compositions composed of peptide nucleic acid strands. In some aspects the peptide nucleic acid strands are complementary to at least a portion of another peptide nucleic acid strand that may have one or more gamma substituents, where the ratio of pna strands is least 1:1.
The Usa, As Represented By The Secretary, Depart- Ment Of Health And Human Services

Surface energy directed cell self assembly

The present disclosure provides a method of fabricating cell, such as stem cell, arrays on a carrier where the surface energy of the carrier has been modified and patterned so that only areas of low contact angle are wet by a water based cell solution. The patterned cell solution when applied to the carrier surface then self assembles into a 3 dimensional micro pattern on the carrier that mimics the surface topography of mammalian organs..
Stemonix Inc.





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This listing is a sample listing of patent applications related to Mammal for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mammal with additional patents listed. Browse our RSS directory or Search for other possible listings.


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