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Mammal patents

      

This page is updated frequently with new Mammal-related patent applications.




 Method and arrangement for matching mammals by comparing genotypes patent thumbnailMethod and arrangement for matching mammals by comparing genotypes
A method for determining a matchmaking quality for a first mammal in relation to a plurality of different second mammals by comparing genotypes thereof, comprises steps of providing a first database and second database. The first database comprises genotyping data of known traits and coefficients weighting severity of said traits, and the second comprises genotyping data for at least certain loci common to each of said mammals to be matchmade.
Genoscoper


 Two plasmid mammalian expression system patent thumbnailTwo plasmid mammalian expression system
Reverse engineering has offered new ways of studying the pathology of rna viral infections, new more efficient devices of synthesizing recombinant viruses and developing vaccines and also demonstrated the versatility and efficiency of rna dependent rna polymerase rdrp system as an expression system. However, the currently used methods require a repertoire of complex, difficult-to-use tools.

 Viral vector manufacture patent thumbnailViral vector manufacture
This present invention relates to a modified mammalian cell in which the genome of the cell is modified to comprise a sequence encoding cp77 under the control of a promoter such that the modified cell line sustains propagation of a poxvirus that is less able or unable to propagate in the unmodified cell.. .
Sementis Limited


 Murine anti-ny-eso-1 t cell receptors patent thumbnailMurine anti-ny-eso-1 t cell receptors
The invention provides an isolated or purified t cell receptor (tcr) having antigenic specificity for ny-eso-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


 10',11'-modified saxitoxins useful for the treatment of pain patent thumbnail10',11'-modified saxitoxins useful for the treatment of pain
Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function, for example conditions associated with pain. The compounds are 10′,11′-modified saxitoxins.
The Board Of Trustees Of The Leland Stanford Junior University


 Systems and methods for phototherapeutic modulation of nitric oxide patent thumbnailSystems and methods for phototherapeutic modulation of nitric oxide
Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used.
Photonmd, Llc


 Systems and methods for phototherapeutic modulation of nitric oxide patent thumbnailSystems and methods for phototherapeutic modulation of nitric oxide
Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used.
Photonmd, Llc


 Skin compatible curing adhesives for adhering devices to mammalian body patent thumbnailSkin compatible curing adhesives for adhering devices to mammalian body
Skin compatible curing adhesives for adhering devices or appliances to mammalian body are disclosed. Adhesive compositions to protect per-anal, peri-stomal, peri-wound, and peri-fistula skin are disclosed.
Trio Healthcare Ltd


 Rna interference functions as an antiviral immunity in mammals patent thumbnailRna interference functions as an antiviral immunity in mammals
The disclosure provides recombinant viral vectors and attenuated viruses and viral vaccines comprising a virus lacking a functional viral rna suppressor of host rnai.. .
The Regents Of The University Of California


 Methods for performing a coronary artery bypass graft procedure patent thumbnailMethods for performing a coronary artery bypass graft procedure
The invention provides methods of treating an obstructive coronary artery disease in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof and performing a coronary artery bypass graft procedure on the subject..
Stealth Biotherapeutics Corp.


Delivery of non-steroidal agents to the brain via the nasal tract to treat neurological disorders

There is described a volatile form of an nsaid, and derivatives thereof, for use in the treatment of a neurological disorder. There is also described a method of treatment of a neurological disorder which comprises administering to a mammal a therapeutically effective amount of a volatile form of an nsaid, or a derivative thereof, in vapour form..

Posaconazole pharmaceutical compositions and preparation methods, uses and pharmaceutical formulations thereof

The present invention relates to a pharmaceutical composition comprising posaconazole and a carrier material, wherein the carrier material comprises a vinylpyrrolidone-vinyl acetate copolymer or a polymer containing ethylene glycol units. The present invention also relates to a method for the preparation of the pharmaceutical composition, a method for the prevention and/or treatment of fungal infections and related diseases in a mammal using the pharmaceutical composition, and a pharmaceutical formulation comprising the pharmaceutical composition..
Sinotherapeutics Inc.

Compositions for an orally active 1,2,4-oxadiazole for the treatment of disease

The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations..
Ptc Therapeutics, Inc.

Compositions and methods for combination pharmacological treatments to induce a prolonged, mild decrease in core body temperature

The present invention is directed to combination pharmacological treatments that induce a prolonged, modest decrease in core body temperature, to the range of ˜95° f. To ˜98.5° f.

Oral anesthesia application

The present invention provides a device for administering an active agent to a localized mucous membrane in the oral cavity of a mammal, as well as an oral dissolving film formed therefore.. .

Vascularized porous metal orthopaedic implant devices

An osteoconductive vascularized porous metal implant device and method for implanting the vascularized device are described herein. The vascularized implant device comprises an implant which is porous titanium, tantalum or other metal which is biocompatible with the mammalian body and at least one vascular conduit which connects the porous implant to an animal vasculature, such as a human vascular system..

Vaso-occlusive devices having expandable fibers

This is a device for occluding a space, for example an aneurysm, within the body. In particular, the device comprising a metallic vaso-occlusive device and expandable fibrous elements.
Boston Scientific Scimed, Inc.

Impedance devices and methods of using the same to obtain luminal organ measurements

Impedance devices and methods of using the same to obtain luminal organ measurements. In at least one embodiment of an impedance device of the present disclosure, the impedance device comprises an elongated body having a distal body end, and a first electrode located along the elongated body at or near the distal body end, the first electrode configured to obtain one or more conductance values within a mammalian luminal organ within an electric field, wherein a measured parameter of the mammalian luminal organ can be calculated based in part upon the one or more conductance values obtained by the first electrode..
3dt Holdings, Llc

Methods and compositions for the production of guide rna

Various aspects and embodiments of the present disclosure relate to methods and compositions that combine multiple mammalian rna regulatory strategies, including rna triple helix structures, introns, micrornas, and ribozymes with cas-based crispr transcription factors and ribonuclease-based rna processing in human cells. The methods and compositions of the present disclosure, in some embodiments, enable multiplexed production of proteins and multiple guide rnas from a single compact rna-polymerase-ii-expressed transcript for efficient modulation of synthetic constructs and endogenous human promoters..
Massachusetts Institute Of Techology

Anthelmintic depsipeptide compounds

The present invention provides cyclic depsipeptide compounds of formula (i) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds.
Merial Inc.

Class of anti-adhesion hydrogels with healing aspects

Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups.
Bvw Holding Ag

Methods and compositions for treatment of metastatic and refractory cancers and tumors

A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the mek/mapk pathway that impairs t cell activation, and administering to said subject a molecule that induces t cell proliferation in the presence of said inhibitor. The combination of a small molecule inhibitor of a target of the mek/mapk pathway and the t cell proliferation inducer reduces the proliferation of the cancer and tumor cells in vivo.
The Wistar Institute Of Anatomy And Biology

Methods of reducing the need for surgery in patients suffering from benign prostatic hyperplasia

The embodiments include methods of treating conditions requiring removal or destruction of cellular elements, such as benign or malignant tumors using compounds based on small peptides in combination with additional active agent(s). The method includes, but is not limited to, administering the compounds intramuscularly, orally, intravenously, intrathecally, intratumorally, intranasally, topically, transdermally, etc., either alone or conjugated to a carrier to a mammal in need thereof.
Nymox Corporation

Peptides having anti-inflammatory properties

Aspects of the present invention relate to peptides having anti-inflammatory activity, compositions containing one or more of the peptides, and use of the peptides to treat conditions associated with excessive inflammation in animals, particularly humans and other mammals.. .
Riptide Bioscience, Inc.

Anthelmintic combinations and methods of use thereof

The present invention relates to a veterinary composition comprising an effective amount of at least one cyclic depsipeptide and at least one macrocyclic lactone; and a pharmaceutically acceptable carrier, for the treatment or prophylaxis of parasitic infection in a mammal wherein the parasite shows resistance to treatment or prophylaxis with the macrocyclic lactone alone.. .
Merial, Inc.

Production and use of bacterial histamine

A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine.
Biogaia Ab

High-loading, controlled-release magnesium oral dosage forms and methods for making and using same

Disclosed are high loading, controlled-release dosage forms for oral administration of magnesium salts. For example, an oral dosage form can comprise from about 80% to about 95% magnesium lactate and one or more components.
Pharmalyte Solutions, Llc

Methods of treating glaucoma using amp-activated protein kinase (ampk) activators

Methods of reducing intraocular pressure in a mammal using ampk activators, e.g., for treating glaucoma.. .
Massachusetts Eye And Ear Infirmary

Method for improving drug treatments in mammals

An improved method for identifying the size, shape and duration of drug exposure necessary to improve drug treatment in a subject with a bacterial infection. In addition, an improved method for identification of new dosing strategies which optimize the probability of positive treatment outcomes in subjects using resistance inhibitory concentration (ric), wherein the subject has a bacterial infection caused by a bacterium with a propensity for heteroresistance.
Zavante Therapeutics, Inc.

Inos-inhibitory compositions and their use as breast cancer therapeutics

Disclosed are methods for treating one or more mammalian cancers, and in particular, methods for treating human breast cancer employing one or more inos pathway-inhibitory compounds, either alone, or in combination with one or more selected antihypertensive agents, including calcium channel antagonists, either alone, and further in combination with one or more conventional chemotherapeutic or anti-cancer regimens. Also disclosed are particular therapeutic formulations including these compositions, and methods for their use in treating refractory, metastatic, and relapsed cancers, and for managing or reversing treatment resistance in human triple-negative breast cancers in particular..
The Methodist Hospital

Biomarkers for assessing kidney diseases

The present invention relates to a metabolic biomarker set for assessing kidney disease comprising at least two amino acids, at least two acylcarnitines and at least two biogenic amines. Moreover, the present invention relates to a method for assessing kidney disease in a mammalian subject which comprises obtaining a biological sample, preferably blood and/or urine, from the subject and measuring in the biological sample the amount of at least two amino acids, of at least two acylcarnitines and of at least two biogenic amines, as well as to a kit adapted to carry out the method.
Biocrates Life Sciences Ag

Kit for monitoring, detecting and staging gvhd

D. Administering an effective amount of at least one immunosuppressant or steroid or a combination thereof to the diagnosed mammal..

Device for detecting misfolded proteins and methods of use thereof

The present invention relates to diagnostic devices as well as methods of using these devices for detecting proteins of interest associated with diseases or disorders in mammals. In particular, the proteins of interest may be misfolded proteins associated with certain misfolded-protein disorders in mammals including those mammals suspected of or at risk of having such disorders..
Gestvision, Inc.

A screening method, a kit, a treatment and a compound for use in a treatment

A method to identify a candidate compound for use in the treatment of a condition involving dysregulation of glucose homeostasis or of glucose uptake in a mammal, by identifying a candidate compound that causes an increase in translocation of glut without causing an increase in the production of camp. A kit for use in such a method.
Atrogi Ab

Asymmetric interfering rna compositions that silence k-ras and methods of uses thereof

The invention provides novel compositions for use in silencing k-ras gene expression. More particularly, the invention provides novel asymmetrical interfering rna molecules as inhibitors of k-ras expression, and to pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal..
Boston Biomedical, Inc.

Methods for in vivo genome editing

Methods of transfecting cells in vivo, by administering an injectable pharmaceutical composition including a genome editing composition and a pharmaceutically acceptable carrier to a subject by hydrodynamic injection into a vessel of the subject are disclosed. Typically, the pharmaceutical composition is administered in a volume and at rate of injection suitable to transfect target eukaryotic cells in the subject with an effective amount of the genome editing composition to alter the genome of the target cells.
Massachusetts Institute Of Technology

Stabilized anti-microbial peptides

The present invention provides methods of designing and making structurally stabilized anti-microbial peptides for the prophylaxis and treatment of infection. Methods are also disclosed for designing stabilized anti-microbial peptides that are selectively lytic/cytotoxic to bacteria, allowing for internal use of anti-microbial peptides without mammalian membrane disruption and cytotoxicity..
Dana-farber Cancer Institute, Inc.

Materials and methods for producing cleaved, hiv-1 envelop glycoprotein trimers

Expression vectors and mammalian cell lines containing them are described that enable the recombinant production of hiv-1 envelope proteins, including sosip modified gp140 trimers capable of inducing broadly neutralizing antibodies.. .
Cornell University

Pyrimidine derivatives

Or pharmaceutically acceptable salts thereof, wherein x, y, z, r1-r11, m, n, and p are defined herein. The novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals.

Platelet-derived growth factor compositions and methods of use thereof

A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/ml to about 1.0 mg/ml in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.. .
Biomimetic Therapeutics, Llc

Conjugates of cysteine engineered antibodies

The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (cba) is covalently linked to the cytotoxic agent through an engineered cys, such as an engineered cys in the heavy chain ch3 domain, at a position corresponds to the eu/ou numbering position 442 (or c442) on an antibody cba. The invention also provides methods of preparing the conjugates of the present invention.
Immunogen, Inc.

Oligosaccharides comprising an aminooxy group and conjugates thereof

The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates.
Genzyme Corporation

Implantable polymeric device for sustained release of sufentanil

Extended release of sufentanil is provided by implanting a device containing sufentanil into a mammal or human being. The device may include a solid biocompatible polymer matrix, and sufentanil may be encapsulated within the polymer matrix.
Antecip Bioventures Ii Llc

Stabilized hypohalous acid solutions

The present invention provides a stabilized hypohalous acid solution (or formulation thereof), which may be conveniently packaged for sale, or stored for later use on demand. The invention further provides methods of making the stabilized hypohalous acid solution, as well as methods of use for disinfecting mammalian tissue, including wounds and burns, disinfecting or cleansing surfaces, or treating and/or preserving food products and cut flowers, among other uses..
Puricore, Inc.

Vaccine compositions

The present disclosure provides vaccine compositions for prophylaxis and treatment of zika virus infections comprising zika virus antigens in immunogenic compositions, and in combination of zika antigens with one or more arbovirus antigens such as chikungunya virus and japanese encephalitis virus antigens, methods of preparation and production of such compositions for use as vaccines for eliciting immune response in mammals against the above mentioned pathogens.. .
Bharat Biotech International Limited

Novel treatment method

There is provided according to the invention a method of treating a mammal suffering from or susceptible to an immune reaction to drug treatment comprising the raising of anti-drug antibodies which method comprises (a) ex-vivo treating antigen presenting cells obtained from the mammal with an agent which induces ido in said antigen presenting cells in the presence of said drug or an epitope containing fragment thereof and (b) after ido has been induced in said antigen presenting cells, transferring said cells back to the mammal thereby to establish immune tolerance to the drug.. .
Idogen Ab

Prostate cancer vaccine

Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer.
Wisconsin Alumni Research Foundation

Methods and materials for reducing the severity of viral infections

This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods and materials for reducing the severity of a viral infection present in a mammal (e.g., a human) are provided..
Mayo Foundation For Medical Education And Research

Methods of treating or preventing pruritis by blocking natriuretic polypeptide b

Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits nppb activity is also disclosed..
The United States Of America, As Represented By The Secretary , Department Of Health & Human Servi

Platelet-derived growth factor compositions and methods of use thereof

A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/ml to about 1.0 mg/ml in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.. .
Biomimetic Therapeutics, Llc

Platelet-derived growth factor compositions and methods of use thereof

A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/ml to about 1.0 mg/ml in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.. .
Biomimetic Therapeutics, Llc

Attenuation of intrapulmonary inflammation

Wherein x1 comprises an amino acid (sequence) with 1 to 4, in particular 1 to 3 members, comprising natural or unnatural amino acids, in particular selected from the amino acid (sequence) c, ksp, k, ornithin, 4-amino butanoic acid, β-alanine, and x2 comprises one amino acid, selected from natural amino acids, in particular selected from the group c, d, g and e, and wherein x1 comprises the n-terminal amino acid at ist first left position and x2 comprises the c-terminal amino acid at its last right position, optionally in the form of a salt for use in the treatment of inflammation, a pharmaceutical composition for treating inflammation comprising such compound and a method of treating inflammation comprising administering an effective amount of such compound to a mammal in need thereof.. .

Inducing brown fat fate and function

Methods and compositions are described herein for generating brown adipose cells and tissues that involve contacting one or more starting cells with bexarotene, ciclopirox, iox2, or combinations thereof. When administered in vivo, subjects receiving bexarotene, ciclopirox, iox2, or combinations thereof have reduced white adipose tissue mass (with enhanced beige features) as well as enlarged brown fat tissue compared to a control mammal that did not receive the bexarotene, ciclopirox, iox2, or combinations thereof.
The J. David Gladstone Instiutes, A Testamentary Trust Established Under The Will Of J. David Glads

Compositions and methods for reducing chronic low-level inflammation

The invention relates to compositions and methods for reducing chronic low-level inflammation associated with chronic conditions. Specifically, the invention relates to compositions of hydrophobic derivatives of aspirin and/or hydrophobic derivatives of sesamol in combination with eicosapentaenoic acid (epa) and docosahexaenoic acid (dha), and their methods for reducing chronic low-level inflammation associated with chronic conditions including obesity, metabolic syndrome, diabetes, cardiovascular disease, cancer, auto-immune disorders, ocular and neurological disorders in a mammal..

Devices, systems, and kits for regulating skin temperature for mammals

A heat transfer system may include a heat transfer machine adapted to thermally couple to an heat transfer pack housed within an heat transfer device and transfer heat from the heat transfer pack using a power supply. The heat transfer device may include a housing and a heat transfer pack.
Slumber Science Llc

Renal function analysis method and apparatus

A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject.
Pharmacophotonics, Inc. D/b/a Fast Biomedical





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This listing is a sample listing of patent applications related to Mammal for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Mammal with additional patents listed. Browse our RSS directory or Search for other possible listings.


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