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This page is updated frequently with new Mammal-related patent applications.




 Method for diagnosing lung cancers using gene expression profiles in peripheral blood mononuclear cells patent thumbnailnew patent Method for diagnosing lung cancers using gene expression profiles in peripheral blood mononuclear cells
Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected gene, e.g., a gene expression profile, from the peripheral blood mononuclear cells (pbmc) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of table i, table ii, table iii, table iv, table v, table vi or table vii herein.
The Trustees Of The University Of Pennsylvania


 Method for diagnosing and monitoring inflammatory disease progression patent thumbnailnew patent Method for diagnosing and monitoring inflammatory disease progression
Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of bdnf and its receptor, ntrk2, in a biological sample from the mammal, and determining that the mammal has endometriosis when the bdnf and ntrk2 expression levels in the sample are elevated..
Mcmaster University


 Method and  detecting vector-borne diseases in mammals patent thumbnailnew patent Method and detecting vector-borne diseases in mammals
Canine subjects are screened for vector-borne diseases using thymidine kinase (tk1) activity level alone or in conjunction with c-reactive protein (crp) as biomarkers in the blood serum. While the canine subject may or may not display health symptoms indicative specifically of a vector-borne disease, the activity level of tk1 or in conjunction with the concentration of crp are combined in a novel method that provides a practitioner the means of determining whether the subjects has a high probability of being affected by a vector-borne disease..
Veterinary Diagnostics Institute, Inc.


 Molecular targets for selective eradication of senescent cells patent thumbnailnew patent Molecular targets for selective eradication of senescent cells
Compositions and methods for selective partial or complete eradication of senescent cells in a mammal are provided. The involves inhibition of the expression of genes that are identified as being related to a senescent phenotype.
Everon Biosciences, Inc.


 A  producing a product (e.g. polypeptide) in a continuous cell culture fermentation process patent thumbnailnew patent A producing a product (e.g. polypeptide) in a continuous cell culture fermentation process
A method for improving productivity in microbial fermentations and mammalian cell culture bioreactors.. .
Cmc Biologics A/s


 Compositions and methods of use of interleukin-10 peptides and anti-interleukin-10 antibodies patent thumbnailnew patent Compositions and methods of use of interleukin-10 peptides and anti-interleukin-10 antibodies
Disclosed herein are methods of reducing a symptom of respiratory disease in a pre-weaned milk-fed mammal by orally administering an isolated antibody that specifically binds the interleukin-10 peptide or an anti-interleukin-10 antibody. Also included are methods of reducing mixing stress in human and non-human mammals by administering an isolated antibody that specifically binds the interleukin-10 peptide or an anti-interleukin-10 antibody.
Wisconsin Alumni Research Foundation


 Cyclic peptide compound, and preparation method, pharmaceutical composition and use thereof patent thumbnailnew patent Cyclic peptide compound, and preparation method, pharmaceutical composition and use thereof
The present invention relates to a cyclic peptide compound, and a preparation method, pharmaceutical composition and use thereof. In particular, the cyclic peptide compound of the present invention has a structure as shown by general formula (i).
Hangzhou Guanyu Bio-medical Co., Ltd.


 Anti-cancer compounds targeting ral gtpases and methods of using the same patent thumbnailnew patent Anti-cancer compounds targeting ral gtpases and methods of using the same
The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a ral gtpase in the mammal. The invention also provides small molecule inhibitors of ral gtpases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same..

 Novel compounds for regeneration of terminally-differentiated cells and tissues patent thumbnailnew patent Novel compounds for regeneration of terminally-differentiated cells and tissues
The present invention discloses novel compounds and their use in medicine. Preferably the compounds are applicable in the therapy of disorders associated with damaged post-mitotic tissues in mammals.
Acousia Therapeutics Gmbh


 Crystalline solid and amorphous forms of (-)-halofenate and methods related thereto patent thumbnailnew patent Crystalline solid and amorphous forms of (-)-halofenate and methods related thereto
The present invention provides crystalline solid and amorphous forms of (−)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to type 2 diabetes and hyperlipidemia.
Cymabay Therapeutics, Inc.


new patent

Drug delivery compositions and methods targeting p-glycoprotein


A composition having general structure (1); wherein the p-gp substrate is a substrate for p-glycoprotein; the linker is a biocompatible polymeric moiety; the drug-loaded carrier comprises a biocompatible framework carrying at least one drug; and the straight line shown in formula (1) between the drug-loaded carrier and linker represents a first bond, and the straight line shown in formula (1) between the linker and p-gp substrate represents a second bond. Also described herein are pharmaceutical compositions containing the above compositions, as well as methods for using these compositions for targeted delivery of a drug to cells expressing higher levels of p-glycoprotein compared to other cells in a mammal, for the treatment of various diseases or conditions, such as cancer and neurological conditions..
Cornell University


new patent

Methods and materials for treatment of pompe's disease


This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.. .
Oxyrane Uk Limited


new patent

Novel pneumovirus compositions and methods for using the same


Provided are newly identified pneumoviruses that can infect mammals, including dogs cats and potentially humans. Isolated polynucleotides and proteins of the viruses, as well as the isolated viruses themselves are provided.
Cornell University


new patent

Interleukin-1 (il-1) inhibitors for treating fertility disorders


The invention provides il-1 inhibitors, methods and uses thereof for retaining ovarian follicle reserve in a mammalian subject, treating infertility and improving responsiveness and sensitivity to coh. The invention further provides methods for improving oocyte quality and/or survival, specifically for ivf, and kits for combining coh treatment with the sensitizing il-inhibitors of the invention..
Tel Hashomer Medical Research Infrastructure And S Ervices Ltd.


new patent

Storage stable lyophilized tripeptide formulations


The invention relates to lysyl-prolyl- threonine lyophilized formulations, in particular to l-lysyl-d-prolyl-l-threonine lyophilized formulations, that are stable in storage, and to a process for preparing the lyophilized formulations. Moreover, the invention relates to pharmaceutical and cosmetic compositions comprising the lyophilized formulations, that are used in the therapeutic and/or prophylactic treatment, diagnosis and/or therapy of pain-related diseases, pruritus-related diseases, inflammatory diseases, and/or other diseases in a mammal..
Dr. August Wolff Gmbh & Co. Kg Arzneimittel


new patent

Kava derived therapeutic compounds and methods of use thereof


Certain embodiments of the invention provide a composition comprising at least two compounds selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the composition is substantially free of flavokawain b. Certain embodiments of the invention also provide a method for treating or preventing cancer in a mammal (e.g., a human) in need of such treatment comprising, administering to the mammal a carrier and a compound selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the compound is substantially free of other kava extract components..
Kuality Herbceutics Llc


new patent

Probiotic recolonisation therapy


The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of bacteroides, eubacteria, fusobacteria, propionibacteria, lactobacilli, anaerobic cocci, ruminococcus, e.
Crestovo Llc


new patent

Probiotic recolonisation therapy


The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of bacteroides, eubacteria, fusobacteria, propionibacteria, lactobacilli, anaerobic cocci, ruminococcus, e.
Crestovo Llc


new patent

Gas filled decellularized matrix


A method to provide an inflated decellularized extracellular matrix of a mammalian organ or a vascularized portion thereof, or a mammalian vascularized tissue or a vascularized portion thereof, an inflated decellularized extracellular matrix of a mammalian organ or a vascularized portion thereof, or a mammalian vascularized tissue or a vascularized portion thereof, and uses thereof, are provided.. .
Miromatrix Medical Inc.


new patent

Method of promoting hair growth by administration of bfgf


Disclosed are a method of promoting hair growth or preventing hair loss in a mammal. In one aspect, the method includes administering interdermally or subcutaneously an agent containing an active ingredient comprising bfgf and a pharmaceutically acceptable substance, wherein bfgf is administered in a dose of 1 μg to 100 μg per 1 cm2 of the target area of hair growth treatment or hair loss prevention and a composition for use in the method..

new patent

Phenyl linked quinolinyl modulators of rorgammat


The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating rorγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1..

new patent

Composition and treatment of ulcers


There is provided pharmaceutical compositions suitable for the treatment of infected ulcers in mammals, such as diabetes related ulcers and varicose ulcers. Said compositions comprising vancomycin, gentamicin, amikacin, fluconazole, ciprofloxacin and metronidazole and sodium chloride in an acidic aqueous media.

new patent

Method and system for diagnosing uterine contraction levels using image analysis


Method of analyzing uterine contractions by analyzing uterine images using deformable model networks in support of embryo transfer techniques. The method is also used to diagnose premature uterine contractile activity in mammals.
Ferring B.v.


Generating definitive endoderm and pancreatic progenitor cells


Compositions and methods of producing mammalian cell populations that include a high proportion of definitive endoderm cells, posterior foregut-like progenitor cells, pancreatic progenitor cells and/or pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes..
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Glads


Usp7 inhibitor compounds and methods of use


2-aminopyridine compounds of formula i are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for modulating usp7, and for treating cancer and immune disorders such as inflammation mediated by usp7. Methods of using compounds of formula i for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
Genentech, Inc.


Method and treating a carotid artery


One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery..
Silk Road Medical, Inc.


Device and combined microfluidic-micromagnetic separation of material in continuous flow


A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps.
President And Fellows Of Harvard College


Peptidic nanodelivery composition targeting two receptors


A polypeptide conjugate for use in a method for binding and/or internalization of the polypeptide conjugate to a mammalian cell having a transferrin receptor (tfrc) and/or receptor for advanced glycation end products (rage). The polypeptide conjugate may be used in a method for targeting of a drug delivery system or diagnostic delivery system..

Compositions and methods relating to c5l2


In some aspects, provided herein is a method of enhancing production of interleukin-17 (il-17), interferon gamma (ifn-γ), or both by a mammalian t cell, the method comprising contacting the cell with a c5l2 inhibitor. In some aspects, provided herein is a method of enhancing th1 and/or th17 responses by a mammalian t cell, the method comprising contacting the cell with a c5l2 inhibitor.
Apellis Pharmaceuticals, Inc.


Methods for treating skin irritation


The present invention provides a stabilized hypohalous acid solution (or formulation thereof), which may be conveniently packaged for sale, or stored for later use on demand. The invention further provides methods of making the stabilized hypohalous acid solutions, as well as methods of use for disinfecting mammalian tissue, including wounds and burns, and treating skin irritations, among other uses..
Puricore, Inc.


Hydrogel formulation for dermal and ocular delivery


Formulations of cross-linkable polymers, capable of forming non-toxic and biocompatible hydrogels in situ, containing at least one of doxycycline or minocycline. Methods of using the hydrogels for treating the skin or ocular tissues of mammals exposed to vesicant compounds such as sulfur mustard (sm), nitrogen mustard (nm) or half mustard (2-chloroethyl ethyl sulfide (cees)) are also disclosed..
Rutgers, The State University Of New Jersey


Therapeutic compounds that suppress protein arginine methyltransferase activity for reducing tumor cell proliferation


The described invention provides methods for modulating gene expression of a gene related to proliferation of a population of tumor cells. The method entails administering a therapeutic amount of a therapeutic compound to a cell, a tissue, or a mammal, wherein the therapeutic amount of the therapeutic compound is effective to suppress methyltransferase activity of a protein arginine methyltransferase.
Epinova Therapeutics Corp.


Therapy for chronic idiopathic urticaria, anaphylaxis and angioedema


Methods for treating or relieving at least one symptom of urticarial disorders including chronic idiopathic urticaria, angioedema, and anaphylaxis, or a combination of these disorders in a mammal, including humans. The method comprises administering to the mammal a therapeutically effective amount of pramipexole, dexpramipexole or pharmaceutically acceptable salts thereof..

Slitted tissue fixation devices and assemblies for deploying the same


Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together include a first member, a second member, and a connecting member extending between the first and second members. One of the first and second members has a configuration alterable by a deployment wire to permit release of the fastener from the deployment wire after deployment and without causing excessive tissue trauma..
Endogastric Solutions, Inc.


Honeybee repellents and uses thereof


The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents.. .
Inscent, Inc.


Methods and materials for assessing immune system profiles


This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of cd4+ lymphocytes, cd8+ lymphocytes, regulatory t cells, b cells, nk cells, granulocytes, cd14+hla-drlo/neg monocytes, and/or cd86+ monocytes per unit volume (e.g., cells per μl or ml) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided..
Mayo Foundation For Medical Education And Research


Vectors and host cells comprising a modified sv40 promoter for protein expression


The present disclosure is directed to expression vectors, comprising a weakened sv40 promoter, and recombinant mammalian cells capable of producing high levels of a polypeptide of interest, methods of generating and using such recombinant mammalian cells.. .
Abbvie Biotherapeutics Inc.


Compositions and methods for silencing ebola virus gene expression


The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering rna such as sirna) that target ebola virus (ebov) gene expression and methods of using such compositions to silence ebov gene expression. More particularly, the invention provides unmodified and chemically modified interfering rna which silence ebov gene expression and methods of use thereof, e.g., for preventing or treating ebov infections caused by one or more ebov species such as zaire ebov.
United States Army Medical Research And Materiel Command


Methods for treating or preventing ophthalmological diseases


This invention relates to methods and compositions useful for the treatment or prevention of an ophthalmological disease, comprising administration of an effective amount of a pdgf antagonist and a vegf antagonist to a mammal in need thereof.. .
Ophthotech Corporation


Recombinant glycoproteins and uses thereof


Provided herein are recombinant glycoproteins (e.g., recombinant human α-galactosidase-a proteins) with an altered (e.g., improved) glycosylation profile, and pharmaceutical compositions and kits including one or more of these proteins. Also provided are methods of generating a mammalian cell useful for recombinant expression of a glycoprotein (e.g., recombinant human α-galactosidase-a), methods of producing recombinant glycoproteins, and methods of treatment that include administering to a subject at least one of the recombinant glycoproteins (e.g., recombinant human α-galactosidase-a protein)..
Genzyme Corporation


New medium for high performance mammalian fed-batch cultures


The present invention relates to new serum- and protein-free culture media. These media are high performance culture media, which notably improve mammalian fed-batch cultures.
Ares Trading S.a.


Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells


One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes.
Cornell Research Foundation, Inc.


System, method, and sterilization with additional nutrients for microbiological inoculation


A method of processing excrement of mammals, fish, birds, reptiles, insects, and/or humans includes sterilizing the excrement to create a sterile fluid, adding one or more nutrients and adding microorganisms such as genus bacillus to the sterile fluid creating a processed fluid. The good microorganisms multiply and divide in the processed fluid, thereby reducing the growth of harmful or unwanted microorganisms in the processed fluid.
Magnegas Corporation


Antibodies reactive with b7-h3 and uses thereof


The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human b7-h3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized b7-h3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers..
Macrogenics, Inc.


Anti-podocalyxin antibodies and methods of using the same


The present invention is directed to compositions of matter useful for the treatment of cancer in mammals and to methods of using those compositions of matter for the same. Antibodies specific for podocalyxin designated ab1 and 3g2 are disclosed, as is the use of said antibodies for the inhibition of growth of a tumor that expresses podocalyxin, and the use of said antibodies for targeting tumour endothelial cells that express podocalyxin..
University Of British Columbia


Anti-ngf antibodies and their use


The present disclosure encompasses ngf binding proteins, specifically to antibodies that are chimeric, cdr grafted and canonized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting ngf and for inhibiting ngf activity, e.g., in a mammal subject suffering from a disorder in which ngf activity is detrimental..
Zoetis Belgium S.a.


Human monoclonal antibodies against the middle east respiratory syndrome coronavirus (mers-cov) and engineered bispecific fusions with inhibitory peptides


The invention provides polypeptides (e.g., antibodies) and fusion proteins that target a epitope in the receptor binding domain (rbd) of the spike (s) glycoprotein of the middle east respiratory syndrome coronavirus (mers-cov). The polypeptides and fusion proteins can be used to treat and prevent mers-cov infection in mammals..
The University Of Hong Kong


Cell, tissue and organ protection using a magnetic field


Methods and apparatus are provided for applying low magnetic fields (<400 g) to mammalian cells, tissues and organs for protection from the damaging effects of ionizing radiation and other oxygen dependent injuries that involve the radical pair mechanism. The magnetic fields are generated by fixed magnets or active magnets and used to enhance the survival of healthy cells during radiation treatment for cancer, to protect workers from radiation within nuclear power plants, to protect astronauts from radiation during long space voyages, to increase working time in exposed environments, to provide a safe room in hazardous locations, and to protect normal tissue during radiation treatment and in medical imaging modalities that use ionizing radiation (x-ray, ct, mammography).
The Trustees Of The University Of Pennsylvania


Method for enhanced uptake of viral vectors in the myocardium


The present invention relates to improved therapies for the treatment of heart disease, particularly the improved delivery of therapeutic agents to heart tissue by direct infusion into the coronary circulation. A preferred embodiment of the invention is a method of treating or preventing a cardiovascular disease by transfecting cardiac cells of a large mammal, the method comprising, identifying a mammal in need of treatment or prevention of heart disease, supplying no to the coronary circulation prior to, and/or during the infusion of a therapeutic polynucleotide into a blood vessel of the coronary circulation in vivo, where the therapeutic polynucleotide is infused into the blood vessel over a period of at least about three minutes, where the coronary circulation is not isolated or substantially isolated from the systemic circulation of the mammal; and where the therapeutic polynucleotide transfects cardiac cells of the animal resulting in the treatment or prevention of the heart disease..
Eiger Biopharmaceuticals, Inc.


Novel maytansinoid derivatives with peptide linker and conjugates thereof


The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (i). The invention also provides novel cytotoxic agents of formula (ii), linker compounds represented by formula (iii), and drug-linker compounds represented by formula (iv).
Immunogen, Inc.


Stimulation of neonatal immunity


The present invention provides methods for inducing an immune response to a pathogen in neonatal mammals. In particular, the present invention provides methods for inducing an immune response to a pathogen in a neonatal mammal comprising administering to the neonatal mammal a composition comprising a fusion protein between interleukin-4 (il-4) and a first antigen of the pathogen..
Cornell University


Joint care composition


The present invention relates to a composition comprising curcuminoid with green tea polyphenol or with a combination of glycine, proline and hydroxyproline for use in preventing or treating osteoarthritis. It also relates to a method of preventing or treating osteoarthritis in mammals, the method comprising administering to said mammal a composition which comprises curcuminoid with green tea polyphenol or with a combination of glycine, proline and hydroxyproline..
Mars, Incorporated


Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same


The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. Via injection, transplantation, or implantation) into a site of soft tissue.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


Use of a3 adenosine receptor agonist in osteoarthritis treatment


Provided is an a3 adenosine receptor agonist (a3ar agonist) for the preparation of a pharmaceutical composition for the treatment of a mammal subject having osteoarthritis (oa), as well as to a method for the treatment of oa in a mammal subject, the method includes administering to said subject in need of said treatment an amount of a3ar agonist, the amount being effective to treat or prevent the development of oa. Preferred but not exclusive a3ar agonists in accordance with the present subject matter are ib-meca and cl-ib-meca.
Can-fite Biopharma Ltd.


Compositions and therapeutic methods for the treatment of complement-associated diseases


The invention comprises methods of modulating the complement cascade in a mammal and for treating and/or preventing diseases and disorders associated with the complement pathway by administering a compound of formula i or formula ii, such as, for example, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3h)-one or a pharmaceutically acceptable salt thereof.. .
Resverlogix Corp.


Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof


Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to rage activity..

Nanoparticle compositions and methods as carriers of nutraceutical factors across cell membranes and biological barriers


Novel process and products thereby emplace nutraceutical factors within nanodelivery vehicles for various indications in mammals, including humans.. .
Nanaspehre Health Sciences, Llc


One step tympanostomy tube and inserting same


A tympanostomy tube for insertion into and residence in a tympanic membrane of a mammal, is disclosed. The tympanostomy tube includes a body including a first end portion, a second end portion, a central portion dispensed between the first and second end portions.
Domestic Legacy Limited Partnership


Pericardial reinforcement device


The following relates to catheter-based devices, systems, and methods for minimally-invasively delivering an inflatable pericardial support into the pericardial space of a mammalian myocardium. The devices and systems include extending and positioning plural support members through a catheter into the pericardial space and then positioning the inflatable member on the epicardial surface of the myocardium.
Beth Israel Deaconess Medical Center, Inc.


Graft devices with spines and related systems and methods


A graft device for a mammalian patient tubular conduit comprises a fiber matrix surrounding the tubular conduit and a spine comprising a first support portion and a second support portion. At least one of the first support portion or the second support portions can be constructed and arranged to rotate relative to the other to receive the tubular conduit.
Neograft Technologies, Inc.


Estrogen receptor alleles that are predictive of increased susceptibility to bone fracture


In one aspect, the present invention provides methods of determining susceptibility to bone fracture in a mammalian subject, wherein the methods comprise analyzing nucleic acid molecules obtained from the mammalian subject to determine which of the p, p x, and x alleles of the estrogen receptor α gene are present, wherein the presence of a haplotype comprising the p and x alleles is indicative of an increased susceptibility to bone fracture. The present invention also provides kits for determining susceptibility to bone fracture in a mammalian subject..
Bodysync, Inc.


Methods of detecting chlamydia and gonorrhea and of screening for infection/inflammation based on genomic copy number


Compositions and methods for detecting chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) are provided. The present invention also provides methods and compositions for screening for infection/inflammation based on genomic copy number.
Cepheid


Method for isolating microorganisms from a complex sample


The present invention relates to a method for isolating and optionally detecting microorganisms from a sample comprising mammalian cells, comprising the use of a lysis buffer comprising benzonase® nuclease. The invention further relates to a lysis buffer comprising benzonase® nuclease and its use..
Merck Patent Gmbh


Reprogramming cells


The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3′-phosphoinositide-dependent kinase-1 (pdk1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.. .
The Scripps Research Institute


Generation and selection of embryos in vitro


Methods of improved monitoring, testing and/or culturing of ova and/or sperm for in vitro fertilization are described herein. Methods of improved monitoring, testing and/or culturing of embryos during ex vivo pre-implantation selection are also described.
Berkeley Lights, Inc.


Methods of treating s. aureus-associated diseases


The present invention provides for methods of preventing and/or treating s. Aureus-associated bacteremia and sepsis, and methods for preventing and/or treating s.
Medimmune, Llc


New 1-(4-pyrimidinyl)-1h-pyrrolo[3,2-c]pyridine derivatives as nik inhibitors


The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders..
Janssen Pharmaceutica Nv


Dual-pump continuous-flow total artificial heart


A total artificial heart for a mammalian cardiovascular system is provided. The total artificial heart has a pump casing including an outer housing and an integral hollow support shaft extending therethrough.
Drexel University


Method and device for lymphedema treatment


Materials and methods are provided to direct the formation of new lymphatics and to reconnect the disrupted lymphatic network. These materials and methods enable to improve survival of lymph nodes and lymph node fragments and their integration into a lymphatic network, following lymph node and lymph node fragments transplantation.
Fibralign Corporation


Radioligands for imaging the lpa-1 receptor


The present invention relates to radiolabeled lpa1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of lpa1 receptors in mammals.. .
Yale University


Modified nucleic acids, and acute care uses thereof


The invention provides compositions and methods for effecting wound healing in a mammal, where the compositions include therapeutic mrna which incorporate modified nucleosides and nucleotides.. .
Moderna Therapeutics, Inc.


Methods for the prevention or treatment of left ventricle remodeling


The disclosure provides methods of preventing, treating, or ameliorating lv remodeling in a mammalian subject. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide such as d-arg-2,6-dmt-lys-phe-nh2..
Heart Institute Good Samaritan Hospital


Method for combined conditioning and chemoselection in a single cycle


A method of radiation-free hematopoietic stem cell (hsc) transplantation comprises administering to a mammalian subject one or two doses of 2 to 10 mg/kg body weight of a purine base analog, such as 6tg as a pre-conditioning step. The method further comprises engrafting into the subject hypoxanthine-guanine phosphoribosyltransferase (hprt)-deficient donor hscs within 48 to 72 hours of the pre-conditioning step; and administering to the subject about 1 to 5 mg/kg of the purine base analog every two to four days for two to eight weeks following the engrafting step.
The Regents Of The University Of California


Use of water soluble platinum complex in preparing drugs for prevention and treatment of cancers


Disclosed in the present invention is the use of a water soluble platinum complex in preparing drugs for the prevention and treatment of tumors, said platinum complex being shown as formula (i). Experiments have demonstrated that the present water soluble platinum complex alone or in combination with other chemotherapeutics is able to treat cancer in mammals, and in particular, humans, said cancers including lung cancer, colon cancer, head and neck cancer, prostate cancer, breast cancer, ovarian cancer, cervical cancer, leukemia, lymphoid cancer, skin cancer, pancreatic cancer, liver cancer, bladder cancer, esophageal cancer, gastric cancer, male genital cancer or bone cancer..
Gudui Biopharma Technology Inc.


Topical regional neuro-affective therapy in mammals with cannabinoids


A method of treating a disease state or condition in mammals other than humans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s) to the back of the neck region and/or spine to provide regional neuro-affective therapy is disclosed. In certain preferred embodiments, the cannabinoid drug(s) are not psychoactive or substantially not psychoactive.
Afgin Pharma, Llc


Assessing renal structural alterations and outcomes


This document provides methods and materials involved in assessing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials involved in assessing outcomes. For example, methods and materials for using the level of urinary cnp (e.g., a urinary to plasma cnp ratio) to determine whether or not a mammal is developing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials for using the level of urinary cnp levels to identify patients having an increased likelihood of experiencing a poor outcome are provided..
Mayo Foundation For Medical Education And Research


Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration


A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer cd4+ th1 response from antigen presenting cells or their precursors and cd4+ t-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“ifn-γ”); and detecting said anti-cancer cd4+ th1 response to determine if said response is depressed. A method for restoring her2-specific cd4+ th1 immune response in a her2-positive breast cancer patient in need thereof, comprising: administering to said patient a therapeutically effective amount of a dendritic cell (“dc”) vaccine comprising autologous dcs pulsed with her2-derived mhc class ii binding peptides (“dc vaccination”) to elevate said patient's anti-her2 cd4+ th1 response; and measuring said anti-her2 th1 response of said patient pre- and post-dc vaccination to determine the amount of increase in said response..

Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins


The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated n-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.. .
Oxyrane Uk Limited


Decreasing potential iatrogenic risks associated with influenza vaccines


Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. On vero, mdck or per.c6 cell lines.
Novartis Ag


Methods for treating cancer in patients with elevated levels of bim


Materials and methods for treating cancer especially in patients identified as having elevated levels of bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of bim, and (b) administering to said mammal an anti-b7-h1 antibody, an anti-pd-1 antibody, an anti-cd80 antibody, or a fusion protein comprising a portion of pd 1 or a portion of cd80, under conditions wherein the interaction of naturally occurring b7-h1 with pd-1 or cd80 in said mammal is reduced after said administering..
Mayo Foundation For Medical Education And Research


Tricyclic benzoxaborole compounds and uses thereof


Wherein x is selected from chloro, fluoro, bromo and iodo, r1 and r2 are each independently selected from h, —ch3, —ch2ch3, —ch2ch2ch3, or —ch(ch3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.. .

Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof


The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof..
Merial Inc


Honeybee repellents and uses thereof


The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents.. .
Inscent, Inc.


Peripheral kappa opioid receptor agonists for preventing, inhibiting or treating nausea and vomiting


A method for preventing, inhibiting or treating nausea and/or vomiting in a mammalian subject, the method comprising administering an effective amount of a peripherally-restricted kappa opioid receptor agonist to the subject. The nausea and/or vomiting can be associated with use of an opioid, such as morphine or fentanyl.
Cara Therapeutics, Inc.


Compositions and methods of use of phorbol esters


Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease.
Biosuccess Biotech Co. Ltd.


Non-lithotripsic kidney-stone therapy


One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy.
The General Hospital Corporation


Method and monitoring quality of a dynamic activity of a body


Apparatus is disclosed for monitoring, measuring and/or estimating metrics and/or combinations of the metrics associated with quality of a dynamic activity of a body or body part of a vertebral mammal. The apparatus includes at least one inertial sensor for measuring relative to a first frame of reference acceleration and/or rotation data indicative of the quality of a dynamic activity and for providing the acceleration and/or rotation data.
Dorsavi Pty Ltd


Non-mammalian ras transgenic animal model


Non-mammalian, transgenic animals, e.g., flies, that include a ras transgene, are provided. Also provided are methods of using the subject transgenic non-mammalian animals to identify compounds having activity with respect to cellular proliferative, such as neoplastic, diseases..
Tosk, Inc.


Animal models and therapeutic molecules


The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.. .
Kymab Limited


Method for producing embryos by in vitro culture, and method, apparatus, and system for selecting embryos


An object of the present invention is to provide a means for efficiently obtaining mammalian embryos having high conception rates. A first aspect of the present invention is a method for selecting a mammalian embryo prepared by in vitro culture from a fertilized egg, comprising a step of selecting an embryo using two or more of the following indicators: the time from fertilization to the completion of first cleavage; the morphology at a stage after first cleavage and before second cleavage; the morphology at a stage after third cleavage and before fourth cleavage; and the amount of oxygen consumed at the early blastocyst stage, the blastocyst stage, or the expanded blastocyst stage..
Dai Nippon Printing Co., Ltd.


Method of identifying biomarkers of neurological diseases and diagnosis of neurological diseases


The present invention provides methods for identifying biomarkers of disease capable of affecting cognitive function. The biomarkers identified by the methods of the prevention may be used for predicting whether a mammal will develop a disease capable of affecting cognitive function.
Crc For Mental Health Ltd


Virus causing respiratory tract illness in susceptible mammals


The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded rna virus (mpv) within the subfamily pneumovirinae of the family paramyxoviridae and identifiable as phylogenetically corresponding to the genus metapneumovirus and components thereof..
Erasmus Universiteit Medical Center Rotterdam


Cells genetically modified to comprise pancreatic islet glucokinase and uses thereof


The present invention relates generally to a population of cells genetically modified to produce insulin in a glucose responsive manner and uses thereof. More particularly, the present invention relates to a population of cells genetically modified to produce insulin in response to physiologically relevant levels of glucose and uses thereof.
University Of Technology, Sydney


Human monoclonal antibodies


The present invention relates, in general, to hiv-1-reactive antibodies and, in at least certain specific embodiments, to broadly neutralizing antibodies (bnabs) (and fragments and derivatives thereof) and to compositions comprising same. The invention further relates to methods of using such bnabs (and fragments and derivatives thereof) and compositions in immunotherapy regimens (e.g., passive immunotherapy regimens).
Duke University


Cell culture processes


Culturing heterologous protein-secreting mammalian cells, such as cho or bhk cells, at 35.1-36.5° c. And/or at ph 7.15-7.20 and/or at a dissolved co2 concentration of 10% or lower.
Baxalta Gmbh


Natriuretic polypeptides with unique pharmacologic profiles


This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity.
Mayo Foundation For Medical Education And Research


Conformationally restricted p13k and mtor inhibitors


The invention relates to novel phosphoinositide 3-kinase (pi3k) and mammalian target of rapamycin (mtor) inhibitor compounds of formula (i) and (ii), which are conformationally restricted, and for which the meaning of the substituents are listed in the description. Preferred compounds are those wherein x isoxygen, r1 is morpholino and r2 is substituted phenyl or heteroaryl.
Piqur Therapeutics Ag


Inhibitors of metallo-beta-lactamase (mbl) comprising a zinc chelating moiety


Compounds according to formula i are provided: a-l-b wherein a represents a lipophilic chelating moiety which is selective for zn2+ions; l is a covalent bond or a linker; and b is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-β-lactamase or dd-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided.
Universitetet I Oslo


Topical nerve stimulator and sensor for control of autonomic function


What is provided is an apparatus and method of modifying a nervous system signal by selectively electrically stimulating a mammalian nerve comprising: applying a dermal patch having an integral electrode in proximity to an axon in a vagus nerve or one or more of its branches or tributaries; determining a stimulation corresponding to the axon in the vagus nerve or the branch or tributary, by logic of the dermal patch; applying the stimulation by the electrodes and a stimulator integral to the dermal patch to produce an electric field; and selectively activating the axon in the vagus nerve or the branch or tributary by the electric field.. .
Neurostim Solutions Llc


Topical nerve stimulator and sensor for sexual function


What is provided is a method and apparatus to modify sexual function by selectively electrically stimulating a mammalian nerve comprising: applying a dermal patch having an integral electrode in proximity to a sensory nerve associated with a penis or clitoris; determining one or more stimulations corresponding to the sensory nerve, by logic of the dermal patch; applying the stimulation by the electrodes and a stimulator integral to the dermal patch to produce an electric field; and selectively activating the sensory nerve by the electric field to produce an action potential in the sensory nerve that travels to a sacral segment of a spinal cord resulting in a reflex that modifies sexual function.. .
Neurostim Solutions Llc


Methods of mammalian retinal stem cell production and applications


The invention provides an in vitro method for producing isolated mammalian primitive retinal stem cells (prscs) comprising: (a) culturing isolated embryonic stem cells (escs) from a mammal in a cell culture medium that is free of feeder cells, feeder-conditioned medium or serum so as to produce and grow a culture of the isolated escs; and (b) contacting the culture of the isolated escs so grown with one or more of an inhibitor for wnt or tgf-β/bmp signaling so as to differentiate the isolated escs of (a) into primitive retinal stem cells thereby producing isolated mammalian prscs.. .
The Regents Of The University Of California


Hyaluronic acid and alginate hydrogel composition


A hydrogel composition comprising an alginate polymer and a hyaluronic acid polymer is a useful polymer scaffold for mammalian tissue engineering. To enable cell adhesion, adhesion peptides may be covalently linked to a portion of the alginate and/or hyaluronic acid.
The Regents Of The University Of California


Surgical adhesive and uses therefore


The present invention provides a liquid polymer composition which can be implanted into a living mammal and which forms a solid hydrogel by in situ polymerization upon contact with body fluid and tissue. The composition also can be used as a coating on a medical device, or for the formation of a medical device.
Promethean Surgical Devices, Llc


Probiotic enhancement of steroid and immune suppressor activity in mammals with chronic diseases


This invention relates to use of probiotics, particularly p acidilactici and s boulardii, for use in conjunction with steroids and other immune suppressor agents to ameliorate symptoms of autoimmune diseases, especially disease symptoms arising from the body's production of antibodies against autologous blood cells. The practice of the invention sustains ameliorative response associated with immune suppressor agents while lowering the amount of immune suppressor agents required for treatment..
Imagilin Technology, Llc


Compositions and methods for restoring or rejuvenating stem/progenitor cell function


This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or improves health of the mammal. In addition, the invention also relates to compositions containing one or more regulatory factors secreted or released from isolated mammalian stem/progenitor cells and use of such compositions to extend lifespan and/or improve health of a mammal.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


Dual vector for inhibition of human immunodeficiency virus


The present invention provides an expression vector for preventing or inhibiting hiv entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a hiv co-receptor, such as ccr5 or cxcr4, and a protein that inhibits hiv fusion to target cells and/or hiv replication.
Calimmune, Inc.


Multipotent stem cells and uses thereof


The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including mhc class i, mhc class ii, cd44, cd45, cd13, cd34, cd49c, cd73, cd105 and cd90. The invention further provides a proliferative stem cell, which expresses genes including oct-4, nanog, sox2, gdf3, p16ink4, bmi, notch, hdac4, tert, rex-1 and twist but does not express cell surface markers including mhc class i, mhc class ii, cd44, cd45, cd13, cd34, cd49c, cd73, cd105 and cd90.
The Brigham And Women's Hospital, Inc.


Levia : a new injectable parasiticidal veterinary formulation of levamisole hcl and ivermectin solution.


This invention provides an improved method for the treatment of helminthiasis in mammals, particularly in: bovines, caprines, equines, ovines, canines and felines.. .

Methods of treating cancer using compositions comprising perillyl alcohol derivative


A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as tmz−poh. The brain metastases can be originated or spread from breast cancer.
Neonc Technologies Inc.


Sparc and methods of use thereof


The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the sparc protein or rna in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or rna from the tumor, a sparc protein or rna detection and quantification means, control rnas, and rules for predicting the response of the tumor based on the level of sparc protein or rna in tumor..
Abraxis Bioscience, Llc


Methods of stabilizing the extracellular matrix and compositions therefor


Disclosed are prophylactic and therapeutic methods, as well as dosing regimens and medicaments for use in preventing chronic disease, for treating acute or long-term inflammatory-mediated conditions in affected or at-risk subjects, and for stabilizing one or more components of the mammalian extracellular matrix. Also disclosed are pharmaceutical compositions and topical formulations thereof that include multiple, phytochemically-active, nutraceutical compounds, and that possess potent anti-inflammatory and extracellular matrix-stabilizing properties both in vitro and in vivo..
Md Matrix Health Llc Dba Md Matrix Health Inc.






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