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Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications. Subscribe to the Mammal RSS feed to automatically get the update: related Mammal RSS feeds. RSS updates for this page: Mammal RSS RSS


Date/App# patent app List of recent Mammal-related patents
07/10/14
20140194612
 Immunosuppression compound and treatment method patent thumbnailImmunosuppression compound and treatment method
A method and compound for suppressing an immune response in a mammalian subject, for the treatment or prevention of an autoimmune condition or transplantation rejection are disclosed. The compound is an antisense oligonucleotide analog compound having a targeting sequence complementary to a preprocessed ctla-4 mrna region identified by seq id no: 22 in seq id no: 1, spanning the splice junction between intron 1 and exon 2 of the preprocessed mrna of the subject.
07/10/14
20140194521
 Use of glutamate, glutamate derivatives or metabolites, glutamate analogues or mixtures thereof for the manufacture of a composition for the treatment of osteoporosis patent thumbnailUse of glutamate, glutamate derivatives or metabolites, glutamate analogues or mixtures thereof for the manufacture of a composition for the treatment of osteoporosis
A method for obtaining improved bone quality in a vertebrate, including mammal and bird, the method comprising administering to a vertebrate, including mammal and bird, in a sufficient amount and/or at a sufficient rate to enable a desired effect, glutamate, glutamate derivatives or metabolites, glutamate analogues or mixtures thereof. Also contemplated is a method for modulating bone quality in a vertebrate, including mammal and bird, comprising administering to the vertebrate, including mammal and bird, in the need thereof, glutamate, glutamate derivatives or metabolites, glutamate analogues or mixtures thereof, for modulating the bone quality as well as a compositions for use in treatment..
07/10/14
20140194520
 Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same patent thumbnailBuffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same
Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a ph of greater than about 10 or less than about 4.5 with low buffer capacity.
07/10/14
20140194500
 Methods for treating of sars patent thumbnailMethods for treating of sars
Provided is a method of treating sars in mammals. The method includes administering a therapeutically effective amount of at least one composition selected from the group consisting of myricetin, scutellarein and a pharmaceutically acceptable salt thereof to a mammal in need of treatment of sars diseases to suppress the activities of sars coronavirus helicase..
07/10/14
20140194462
 Alpha-7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof patent thumbnailAlpha-7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
The present application is related to compounds represented by formula i, which are novel allosteric modulators of α7nachr. The application also discloses the treatment of disorders that are responsive to modulation of acetylcholine action on α7nachr in a mammal by administering an effective amount of a compound of formula i..
07/10/14
20140194408
 Heteroaryl pyridone and aza-pyridone compounds patent thumbnailHeteroaryl pyridone and aza-pyridone compounds
Heteroaryl pyridone and aza-pyridone compounds of formula i are provided, where one or two of x1, x2, and x3 are n, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting btk kinase, and for treating immune disorders such as inflammation mediated by btk kinase. Methods of using compounds of formula i for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
07/10/14
20140194346
 Pasteurellaceae vaccines patent thumbnailPasteurellaceae vaccines
The present invention relates to an n-glycosylated protein for treating and/or preventing bacterial pasteurellaceae infection in a mammal or bird, wherein the protein is a pasteurellaceae protein, a functional fragment or derivative thereof having at least one glycosylated n-x-s/t consensus sequence. In addition, the present invention is directed to corresponding pharmaceutical compositions for treating and/or protecting mammals or birds having or being prone to develop a bacterial pasteurellaceae infection.
07/10/14
20140193525
 Methods for treating or preventing radiocontrast agent induced kidney injury patent thumbnailMethods for treating or preventing radiocontrast agent induced kidney injury
Methods for treating or preventing radiocontrast agent induced kidney injury in a mammal are disclosed, the methods comprising administering to the mammal a first effective amount of a chalcogenide composition prior to administering a radiocontrast agent to the mammal.. .
07/10/14
20140193516
 Methods for treating glucose metabolic disorders patent thumbnailMethods for treating glucose metabolic disorders
In one aspect, the invention relates to methods for treating a disease or condition associated with abnormal glucose metabolism. In another aspect, the invention relates to a method for reducing incidence or progression of insulin-dependent diabetes mellitus.
07/10/14
20140193494
 Misuse preventative, controlled release formulation patent thumbnailMisuse preventative, controlled release formulation
Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the core, and a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed within the core, the coat, or both the core and the coat. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present in the coreswells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the formulation.
07/10/14
20140193483
Therapeutic vaccines for treating herpes simplex virus type-2 infections
The invention provides methods and kits for inducing a therapeutic immunity in animals (e.g. Mammals) against viral antigens, including herpes-simplex virus type 2.
07/10/14
20140193480
Topical anti-inflammatory compositions and uses thereof
Disclosed are pharmaceutical compositions and topical formulations thereof that include multiple, phytochemically-active, nutraceutical compounds, and that possess potent anti-inflammatory and extracellular matrix-stabilizing properties both in vitro and in vivo. Also disclosed are prophylactic and therapeutic methods, as well as dosing regimens and medicaments for use in preventing chronic disease, for treating acute or long-term inflammatory-mediated conditions in affected or at-risk subjects, and for stabilizing one or more components of the mammalian extracellular matrix..
07/10/14
20140193479
Compositions and methods for treatment of mammalian skin
Compositions useful for treatment of a wide range of skin disorders including: pre-cancerous lesions, keratotic lesions, superficial basal cell carcinomae; squamous cell carcinomae; malignant melanoma, and radiation-induced burns. In some embodiments the treatments comprise contacting human or other mammalian skin with a composition according to the disclosure.
07/10/14
20140193478
Compositions and methods for treatment on mammalian skin
Compositions useful for treatment of a wide range of skin disorders including: pre-cancerous lesions, keratotic lesions, superficial basal cell carcinomae; squamous cell carcinomae; malignant melanoma, and radiation-induced burns. In some embodiments the treatments comprise contacting human or other mammalian skin with a composition according to the disclosure.
07/10/14
20140193458
Method of vaccination comprising a histone deacetylase inhibitor
A vaccination method is provided. The method comprises administering to a mammal a histone deacytelase inhibitor in conjunction with a vaccine that expresses an antigen to which the mammal has a pre-existing immunity..
07/10/14
20140193430
Compositions and methods for regulating nk cell activity
The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of nk cells and allow a potentiation of nk cell cytotoxicity in mammalian subjects.
07/10/14
20140193408
Soluble proteins for use as therapeutics
The present invention relates to improved binding proteins, for use as a medicament, in particular for the prevention or treatment of autoimmune and inflammatory disorders, for example allergic asthma and inflammatory bowel diseases. The invention more specifically relates to a soluble protein, comprising a complex of two heterodimers, wherein each heterodimer essentially consists of: (i) a first single chain polypeptide comprising: (a) an antibody heavy chain sequence having vh, ch1, ch2, and ch3 regions; and (b) a monovalent region of a mammalian binding molecule fused to the vh region; and (ii) a second single chain polypeptide comprising: (c) an antibody light chain sequence having a vl and cl region; and (d) a monovalent region of a mammalian binding molecule fused to the vl region; characterised in that each pair of vh and vl cdr sequences has specificity for an antigen, such that the total valency of said soluble protein is six.
07/10/14
20140193384
Use of lactobacillus for liver protection
A method for liver protection of a mammal is provided and includes administering an effective amount of isolated lactobacillus plantarum cmu995 thereto. Providing a new use of lactobacillus plantarum cmu995, which is deposited at the food industry research and development institute (firdi) in taiwan under accession number bcrc 910472 and in the german collection of microorganisms and cell cultures (dsmz) under accession number dsm 23780..
07/10/14
20140193382
Endogenous expression of hla-g and/or hla-e by mesenchymal cells
Methods and compositions are provided for the identification and isolation of mammalian hla-g+ msc, hla-e+ msc, or hla-g+/hla-e+ msc. The methods of the invention provide a means to obtain enriched hla-g+ msc, hla-e+ msc, or hla-g+/hla-e+ msc populations..
07/10/14
20140193332
Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders
The present invention is directed to compositions of matter useful for the diagnosis and treatment of inflammatory bowel diseases in mammals and to methods of using those compositions of matter for the same.. .
07/10/14
20140193330
Compositions and methods for multimodal imaging
There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier.
07/10/14
20140192617
System for acquiring seismic data in a marine environment, using seismic streamers coupled to means for detecting and/or locating marine mammals
Discloses herein is a system of acquiring seismic date in a marine environment, which includes: seismic streamers towed by a vessel; and means for detecting and/or locating marine mammals, characterised in that said marine mammal detection and/or location means are secured to said seismic streamers.. .
07/03/14
20140189897
Transgenic animals capable of being induced to delete senescent cells
This document relates to methods and materials involved in the removal of senescent cells within a mammal. For example, transgenic non-human animals that can be induced to delete senescent cells are provided..
07/03/14
20140188154
Electronic device for weight control
Orally administrable polymer-carrying units for expanding in a stomach of a mammal to fill a space in the stomach, the polymer-carrying units including: a carrier; a plurality of polymer molecules expandable in aqueous solutions, releasably coupled to the carrier; and means for selectively decoupling the polymer molecules from the carrier so that the polymer molecules and carrier are released in the stomach, are provided.. .
07/03/14
20140188024
Device and method for applying pressure to mammalian limb
A therapeutic pressure strap for applying pressure across a muscle or muscle groups on a mammalian limb is described. The strap is particularly well suited for treating “tennis elbow”.
07/03/14
20140187640
N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress
Methods and compositions comprising n-acetylcysteine amide (nac amide) and derivatives thereof are used in treatments and therapies for human and non-human mammalian diseases, disorders, conditions and pathologies. Pharmaceutically or physiologically acceptable compositions of nac amide or derivatives thereof are administered alone, or in combination with other suitable agents, to reduce, prevent, or counteract oxidative stress and free radical oxidant formation and overproduction in cells and tissues, as well as to provide a new source of glutathione..
07/03/14
20140187612
Method of modulating integrin mediated cellular activity and agents useful for same
An isolated nucleic acid encodes a polypeptide for inhibiting growth of a cancer cell. The amino acid sequence defines a binding domain of a β integrin subunit for erk2 map kinase, the binding domain comprising an intervening, centrally located amino acid linker sequence that links opposite terminal end amino acid sequence regions of the binding domain together and is non-essential for binding of the map kinase to the binding domain.
07/03/14
20140187602
Anti-sense oligonucleotides targeted against exon 9 of il-23r alpha gene and method of using same to induce exon skipping and to treat inflammatory bowel diseases
The present invention relates to anti-sense oligonucleotides (aons) used to induce exon 9 skipping in il-23rαgene. Exon 9 skipping of the il23rα gene ultimately causes specific induction of a novel soluble truncated il-23rα (Δ9) protein, characterized by a lack in a transmembrane domain and has a unique eight (8) amino acids (glkegsyc) at its c-terminus end as a result of frame-shift.
07/03/14
20140187584
Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and method of reducing tnfalpha levels
Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of tnfα in a mammal..
07/03/14
20140187505
Cardiac glycosides to treat cystic fibrosis and other il-8 dependent disorders
Disclosed is the use of a cardiac glycoside to decrease or inhibit the secretion of proinflammatory mediators in the treatment of disease conditions characterized by elevated levels of the proinflammatory mediator. The cardiac glycoside is administered to a mammalian subject in need of such treatment, and dosage is adjusted to the mass of the recipient and the need of the recipient to reduce or inhibit the level of the proinflammatory mediator.
07/03/14
20140187490
Val (8) glp-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome
A method of treating functional dyspepsia and/or irritable bowel syndrome in mammals in need of treatment is disclosed herein. The method comprises administering to the mammal a formulation by inhalation, wherein the formulation avoids first pass metabolism of the active ingredient.
07/03/14
20140187483
Glp-1 and methods for treating diabetes
The present invention relates to use of glp-1 or a related molecule having glp-effect for the manufacture of a medicament for preventing or treating diabetes in a mammal. The amount and timing of administration of said medicament are subsequently reduced to produce a “drug holiday”.
07/03/14
20140186955
Generation of neuronal cells from pluripotent stem cells
The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population..
07/03/14
20140186471
Composition for inhibition of cathepsin k
The present invention relates to the a method of inhibiting bone resorption in a mammal in need thereof with an oral pharmaceutical composition comprising a cathepsin k inhibitor, or a pharmaceutically acceptable salt thereof, or a mixture thereof, according to a continuous schedule having a dosage interval of once weekly, biweekly, twice monthly or once monthly.. .
07/03/14
20140186440
Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage form provides delivery of the drugs to the upper gastrointestinal tract (“gi”) of a mammal for an extended period of time..
07/03/14
20140186400
Methods and compositions for treating autoimmune diseases
The invention features methods for increasing or maintaining the number of functional cells of a predetermined type, for example, insulin producing cells of the pancreas, blood cells, spleen cells, brain cells, heart cells, vascular tissue cells, cells of the bile duct, or skin cells, in a mammal (e.g., a human patient) that has injured or damaged cells of the predetermined type.. .
07/03/14
20140186398
Bacterial rnas as vaccine adjuvants
The disclosure features vaccine adjuvants comprising prokaryotic mrna, and methods of vaccination using the adjuvants. More specifically, the disclosure provides a vaccine composition comprising a nonviable immunogen (e.g., heat-killed bacterium), a tumor antigen, or an immunogenic peptide of microbial or mammalian origin, and an adjuvant, wherein adjuvant comprises prokaryotic mrna (e.g., bacterial mrna), as well as the methods of using the vaccine compositions.
07/03/14
20140186382
Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
The invention is related to polynucleotide-based cytomegalovirus vaccines. In particular, the invention is plasmids operably encoding hcmv antigens, in which the naturally-occurring coding regions for the hcmv antigens have been modified for improved translation in human or other mammalian cells through codon optimization.
07/03/14
20140186375
Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.. .
07/03/14
20140186356
Combination of a c-met antagonist and an aminoheteroaryl compound for the treatment of cancer
The invention also relates to a composition comprising an antibody antagonist to c-met and an aminoheteroaryl compound, particularly as a medicament. The present invention also comprises a pharmaceutical composition comprising said anti c-met antibody and said aminoheteroaryl compound as combination products for simultaneous, separate or sequential use.
07/03/14
20140186323
Factor viia-polysialic acid conjugates having prolonged in vivo half-life
The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor viia (fviia) or biologically active derivatives thereof, which are bound to a carbohydrate moiety comprising 1-4 sialic acid units, wherein the in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal, as compared to the in vivo half-life of a fviia molecule not bound to a carbohydrate moiety. The invention also provides a method for controlling bleeding in a mammal having a bleeding disorder due to functional defects or deficiencies of fviia, fviii, or fix.
07/03/14
20140186314
Pure populations of astrocyte restricted precursor cells and methods for isolation and use thereof
An isolated, pure homogeneous population of mammalian astrocyte restricted precursor cells which is cd44 immunoreactive and which generate astrocytes but not oligodendrocytes is provided. Methods for isolating and using these mammalian astrocyte restricted precursor cells are also provided..
06/26/14
20140182005
Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein
The present invention provides sperm cell targeting ligands, including dna-binding proteins, that bind target molecules on the surface of, accessible from the surface of, or inside mammalian sperm cells and methods for producing the sperm cell targeting ligands. The sperm cell targeting ligands are used to separate sperm cells based upon sperm cell qualities, such as whether the cells contain x chromosomes or y chromosomes.
06/26/14
20140182004
Mouse model of retinal degeneration
The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (amd).
06/26/14
20140182003
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.. .
06/26/14
20140180413
Silk covered prosthesis
Disclosed herein are polyurethane polymer matrices with a porosity of from about 20 microns to about 90 microns that are useful in promoting closure and protection of incision sites; supporting the lower pole position of breast implants; and providing a partial or complete covering of breast implants to provide a beneficial interface with host tissue and to reduce the potential for malpositioning or capsular contracture. The disclosed matrices can be seeded with mammalian cells..
06/26/14
20140180204
Apparatus and method for treating tissue
An apparatus for treating tissue of a mammalian body. In one embodiment, a spring mechanism is carried by first and second tubular members and actuatable for moving a needle from a first position disposed within the distal extremity of the first tubular member to a second position extending distally of the first tubular member.
06/26/14
20140179877
Macromolecule conjugate
The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules..
06/26/14
20140179756
Modified sirna molecules and uses thereof
The present invention provides chemically modified sirna molecules and methods of using such sirna molecules to silence target gene expression. Advantageously, the modified sirna of the present invention is less immunostimulatory than its corresponding unmodified sirna sequence and retains rnai activity against the target sequence.
06/26/14
20140179709
Antiviral agents
Their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula i.. .
06/26/14
20140179655
Solid oral dosage form of testosterone derivative
The present invention relates to a composition, particularly a pharmaceutical composition comprising a testosterone derivative having a log p of at least 5 and a vehicle, wherein the vehicle comprises a fat component in an amount sufficient to achieve lymphatic absorption in a mammal, wherein the fat component comprises a mono- or triglyceride of long chain fatty acids. .
06/26/14
20140179621
Methods for treating or preventing ophthalmological diseases
This invention relates to methods and compositions useful for the treatment or prevention of an ophthalmological disease, comprising administration of an effective amount of a pdgf antagonist and a vegf antagonist to a mammal in need thereof.. .
06/26/14
20140179620
Gene expression markers for inflammatory bowel disease
The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of one or more ibd markers relative to a control is determined, wherein the differential expression in the test sample is indicative of an ibd in the mammalian subject from which the test sample was obtained.. .
06/26/14
20140179610
Treatment of type 2 diabetes, metabolic syndrome, myocardial injury and neurodegeneration with humanin and analogs thereof
Provided are methods of using humanin and humanin analogs to treat a mammal exhibiting or at risk for insulin resistance, increase insulin sensitivity in a mammal exhibiting or at risk for insulin resistance, treat type-2 diabetes mellitus, metabolic syndrome, and neurodegeneration, treat and prevent myocardial injury, and determine longevity.. .
06/26/14
20140179605
Natriuretic polypeptide delivery systems
This document provides natriuretic polypeptide delivery systems. For example, methods and materials related to natriuretic polypeptide delivery systems, methods and materials related to the use of such delivery systems to deliver natriuretic polypeptides to a mammal over a pro-longed period of time (e.g., weeks to months), and methods and materials related to treating heart failure conditions are provided..
06/26/14
20140179604
Ghrh agonists for the treatment of ischemic disorders
Disclosed herein are compositions of ghrh agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one ghrh agonist peptide to the subject.
06/26/14
20140179005
Methods and products for producing engineered mammalian cell lines with amplified transgenes
Methods of inserting genes into defined locations in the chromosomal dna of cultured mammalian cell lines which are subject to gene amplification are disclosed. In particular, sequences of interest (e.g., genes encoding biotherapeutic proteins) are inserted proximal to selectable genes in amplifiable loci, and the transformed cells are subjected to selection to induce co-amplification of the selectable gene and the sequence of interest.
06/26/14
20140178987
Stem cell culture medium and its applications as well as a stem cell culture method
The present invention discloses a stem cell culture medium and its applications as well as a stem cell culture method. The said stem cell culture medium contains no serum.
06/26/14
20140178984
Method for culturing mammalian cells to improve recombinant protein production
The present invention relates to methods for mammalian cell culture. The methods make use of independent tyrosine and cystine feed streams..
06/26/14
20140178967
Mammalian cells for propagating virus
The present invention relates to mammalian cells capable of propagating arterivirus, to such cells infected with arterivirus, to cell cultures comprising such cells and to methods for the propagation of an arterivirus in such cells.. .
06/26/14
20140178854
Antisera assays for mlv related viruses in humans and other mammals
The disclosure provide cell lines and methods for the production of vectors and viral particles useful in diagnostics and therapeutics.. .
06/26/14
20140178448
Continuous culturing device
A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas.
06/26/14
20140178406
Use of goat serum for veterinary treatment
Methods for veterinary treatment of mammals are described, for treatment of conditions having an inflammatory component. The methods are particularly suited to treatment of cats, dogs, or horses..
06/26/14
20140178398
Vascular disruption agents and uses thereof
Uses of apo2l/trail polypeptides and death receptor agonist antibodies to disrupt tumor associated vasculature are provided. Methods of treating cancer in mammals, kits, and articles of manufacture are also provided..
06/26/14
20140178388
Multivalent antibody fragments and trimerized complexes thereof
The present invention relates to a method for producing multivalent fab fragments. In particular, the invention relates to a method for the generation of trimeric fab fragments by co-expression of a gene construct comprising a heavy chain portion of a fab fragment and an in-frame fused collagen-like peptide, and a gene construct consisting of a light chain portion of an igg in mammalian cells.
06/26/14
20140178379
Therapeutic nuclease compositions and methods
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.. .
06/26/14
20140178364
Compositions and methods for targeting type 1 interferon producing cells
The present disclosure provides a method for treating lupus, sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor α (il-3rα) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p dcs) and basophils to which it binds.. .
06/26/14
20140178354
Salinosporamides and methods of use thereof
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains cnb392 and cnb476 are effective inhibitors of hyperproliferative mammalian cells. The cnb392 and cnb476 strains lie within the family micromonosporaceae, and the generic epithet salinospora has been proposed for this obligate marine group.
06/26/14
20140178304
Radiolabeled compounds and their use as radiotracers for quantitative imaging of phosphodiesterase (pde10a) in mammals
The present invention provides radiolabeled compounds useful as radiotracers for quantitative imaging of pde10a in mammals. The compound of the present invention is represented by the formula (i): wherein each symbols are as defined in the specification..
06/26/14
20140173883
Methods of making electromechanical personal care device
A method of making a handheld, electromechanical device useful in mammalian body-care includes the steps of: a) forming a one-piece housing having a single opening defined by a rim; b) assembling a unitary insert; c) inserting the unitary insert through the single opening of the housing; d) removably applying a cover having an exterior surface to close the opening of the one-piece housing; and e) attaching the unitary insert to at least one of the one-piece housing and the removable cover. The rim of the one-piece housing circumscribes a rim area, and the one-piece housing has a projected area that is substantially larger than the rim area.
06/19/14
20140173777
Methods for elevating fat/oil content in plants
In some embodiments, the present invention provides a method of elevating lipid content in vegetative (non-seed) plant or algae cells, plant tissues, or whole plants by genetically modifying the plant or algae to express a lipid droplet-associated protein or polypeptide (such as fat-specific protein 27) of mammalian origin. Also provided are genetically-modified plant or algae cells, plant tissues, or whole plants with elevated cellular lipid content, expressing a lipid droplet-associated protein or polypeptide (such as fat-specific protein 27) of mammalian (e.g.


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