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Mammal patents



      
           
This page is updated frequently with new Mammal-related patent applications. Subscribe to the Mammal RSS feed to automatically get the update: related Mammal RSS feeds. RSS updates for this page: Mammal RSS RSS


Pseudobezoar-based intraluminal gastrointestinal cleansing and biospy

Pseudobezoar-based intraluminal gastrointestinal cleansing and biospy

Formulation of solid nano-sized particles in a gel-forming system

Formulation of solid nano-sized particles in a gel-forming system

Formulation of solid nano-sized particles in a gel-forming system

Wireless monitoring device

Date/App# patent app List of recent Mammal-related patents
11/20/14
20140343673
 Extracellular matrix encasement structures and methods patent thumbnailExtracellular matrix encasement structures and methods
A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region and at least one lead conduit, the internal region being configured to receive a device therein, the lead conduit being configures to receive at least one device lead therein, the bioremodelable material comprising an extracellular matrix (ecm) composition that includes an ecm component derived from a mammalian source.. .
11/20/14
20140343452
 Pseudobezoar-based intraluminal gastrointestinal cleansing and biospy patent thumbnailPseudobezoar-based intraluminal gastrointestinal cleansing and biospy
The present disclosure describes an orally administrable implement comprising expandable material designed specifically to swell in a targeted gastrointestinal (gl) organ of a mammal, including human to form a pseudobezoar, so that upon swelling it touches the walls of the targeted organ. In one design, the swollen pseudobezoar provides sponge-like cleansing of the targeted gl organ to prepare the said organ for further examination.
11/20/14
20140343413
 Formulation of solid nano-sized particles in a gel-forming system patent thumbnailFormulation of solid nano-sized particles in a gel-forming system
The present invention relates to novel formulations comprising a plurality of nano-sized solid particles and a gel-forming system, useful, e.g. For imaging of the body of a mammal.
11/20/14
20140343389
 Wireless monitoring device patent thumbnailWireless monitoring device
The present invention relates to a monitor and monitoring system suitable for attachment to the skin of a mammal, including a human. The monitor and monitoring system are designed for continuous wireless real-time measurement of physiological signals and transmission of the measurements to a remote computer or mobile device..
11/20/14
20140343256
 Tlr2 antagonistic antibody and use thereof patent thumbnailTlr2 antagonistic antibody and use thereof
The present invention is directed to a cross-reactive antibody, which specifically inhibits or blocks the mammalian toll-like receptor 2 (tlr2)-mediated immune cell activation. The invention is further directed to an isolated nucleic acid or vector coding for the variable regions of the heavy and/or light chain of said antibody.
11/20/14
20140343252
 Interleukin-2 muteins for the expansion of t-regulatory cells patent thumbnailInterleukin-2 muteins for the expansion of t-regulatory cells
Provided herein are il-2 muteins and il-2 mutein fc-fusion molecules that preferentially expand and activate t regulatory cells and are amenable to large scale production. Also provided herein are variant human igg1 fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at n297.
11/20/14
20140343147
 Nutritional supplement for the enhancement of muscle performance and recovery and methods of use thereof patent thumbnailNutritional supplement for the enhancement of muscle performance and recovery and methods of use thereof
Described herein are nutritional supplements containing α-hydroxy-isocaproic acid and aspartic acid (e.g., daa) and their methods of use in enhancing muscle performance and/or recovery after exercise. The nutritional supplements can be used to enhance muscle building and lean body mass, enhance muscle and physical performance, enhance recovery, and prevent catabolism (muscle atrophy or wasting) when administered to a mammalian subject..
11/20/14
20140343129
 Modified nucleic acids, and acute care uses thereof patent thumbnailModified nucleic acids, and acute care uses thereof
The invention provides compositions and methods for effecting wound healing in a mammal, where the compositions include therapeutic mrna which incorporate modified nucleosides and nucleotides.. .
11/20/14
20140343059
 Novel piperazines, pharmaceutical compositions and methods of use thereof patent thumbnailNovel piperazines, pharmaceutical compositions and methods of use thereof
Disclosed are novel piperazine derivatives that act as agonists of the α7 nachr. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating cns disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds..
11/20/14
20140342988
 Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment patent thumbnailAdrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment
Methods of treating a mammal at risk for ischemia-reperfusion injury are provided. The methods comprise administrating an adrenomedullin binding protein-1 (ambp-1) to the mammal in sufficient amount to reduce the injury.
11/20/14
20140342428
Genetic regulation of bone and cells by electromagnetic stimulation fields and uses thereof
The present invention provides methods to modify the genetic regulation of mammalian tissue, bone, cells or any combination thereof by preferential activation, up-regulation and/or down-regulation. The method comprises steps of tuning the predetermined profiles of one or more time-varying stimulation fields by manipulating the b-field magnitude, rising slew rate, rise time, falling slew rate, fall time, frequency, wavelength, and duty cycle, and exposing mammalian cells or tissues to one or more tuned time-varying stimulation fields with predetermined profiles.
11/20/14
20140342401
Promoter derived from human gene
The present invention relates to a transfected mammalian host cell whose ability to secrete a foreign protein has been enhanced by using a foreign gene expression vector having a promoter derived from a human gene, and a method for producing the foreign protein using the host cell. A method for enhancing the production of a foreign protein to be used in a pharmaceutical protein product in a host cell such as a cultured mammalian cell is provided.
11/20/14
20140342389
Method and composition for a protein transduction technology and its applications
A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has cation reagents, lipids and enhancers in a carrier.
11/20/14
20140342004
Functionalized nanoparticles for intracellular delivery of biologically active molecules
Functionalized biocompatible nanoparticles capable of penetrating through a mammalian cell membrane and delivering intracellularly a plurality of bioactive molecules for modulating a cellular function are disclosed herein the functionalized biocompatible nanoparticles comprise: a central nanoparticle ranging in size from about 5 to about 50 nm and having a polymer coating thereon, a plurality of functional groups covalently attached to the polymer coating, wherein the plurality of bioactive molecules are attached to the plurality of the functional groups, and wherein the plurality of bioactive molecules include at least a peptide and a protein, and wherein the peptide is capable of penetrating through the mammalian cell membrane and entering into the cell, and wherein the protein is capable of providing a new functionality within the cell. The protein may be a transcription factor selected from the group consisting of oct4, sox2, nanog, lin28, cmyc, and klf4..
11/20/14
20140341952
Method of treatment of diseases using hoodia extracts
A method for treating a disease comprising administering to a mammal in need thereof an effective dosage of an extract of a plant of the genus hoodia, wherein the disease is selected from the group consisting of immune-mediated disorders, immune-associated disorders, inflammatory diseases, coronary disease, insulin resistance and liver-related diseases. In a preferred embodiment, the hoodia is hoodia parviflora.
11/20/14
20140341879
Methods for the prevention or treatment of vessel occlusion injury
This invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof wherein the peptide is d-arg-26-dmt-lys-phe-nh2 (ss-31)..
11/20/14
20140341870
Biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite and a method of treating injuries
Provided is a biocomposite including cells, a genetic construction, and a scaffold and a method for repairing tissue and organs in mammalians with the biocomposite. The interaction of the components of the biocomposite provides a complex effect on reparative regeneration processes.
11/20/14
20140341852
Capsid-modified raav vector compositions and methods therefor
Disclosed are capsid-modified raav expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated raav constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors.
11/20/14
20140341841
Mirna biomarkers for radiation biodosimetry
Disclosed herein are mirna biomarkers and methods for measuring exposure of a mammalian subject to ionizing radiation using a cell-free biological sample. Also disclosed are dosimeters and methods for triaging and treating a subject exposed to ionizing radiation..
11/13/14
20140338008
Organ regeneration method utilizing ips cell and blastocyst complementation
It is revealed that an organ such as pancreas can be regenerated by utilizing a fact that the deficiency of an organ is complemented by injecting an induced pluripotent stem cell (ips cell) into a developed blastocyst in a blastocyst complementation method. Thus, the present invention has solved the above-described object.
11/13/14
20140336626
Medical assembly using short pulse fiber laser
A method of ablating a solid substance within a mammalian body is presented. The method includes generating a superheated zone within the body using a fiber lasing assembly that emits pulses at a pulse repetition rate of 1 khz to 500 khz, where each pulse has a wavelength from 1.7 micron to 2.2 micron, a pulse width from 2 ns to 800 ns, and a pulse energy from 0.05 mj to 2 mj.
11/13/14
20140336579
Infusion set with quick connect, self-aligned electrical contacts
A device and method for delivering a therapeutic substance to the body of a mammal are provided. The device includes a pump adapter, a pump, and an infusion set having a distal connector and a proximal connector.
11/13/14
20140336478
Optical sensor device and image processing unit for measuring chemical concentrations, chemical saturations and biophysical parameters
Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations, vital signs and physiological information such as a malignant condition are provided. In some embodiments, the optical sensor includes an array of photodetectors, where each photodetector is configured to detect a spectrum of light.
11/13/14
20140336244
Methods and products for reawakening retrocyclins
Products and methods are provided for the restoring the endogenous expression of theta-defensins, such as retrocyclin-1, in mamallian cells. The present invention also includes products and methods for inhibiting sexually transmitted virus entry, e.g., hiv-1 virus entry, into a mammalian cell via, for example, administering to a subject an amount of a read-through mediating agent sufficient to induce exogenous expression of an amount of retrocyclin nonapeptides in the mammalian cell..
11/13/14
20140336212
Combination analgesic employing opioid agonist and neutral antagonist
In some embodiments, the invention provides a non-addictive analgesic co-formulation comprising an opioid agonist in an amount sufficient to confer analgesia in a mammalian subject (such as a human) and a neutral opioid antagonist in an amount sufficient to inhibit peripheral effects of the opioid agonist, and insufficient to block substantial central effects of the opioid agonist in the subject. The formulation may be formulated for oral administration to the subject.
11/13/14
20140336188
N-substituted indenoisoquinolines and syntheses thereof
N-substituted indenoisoquinoline compounds, and pharmaceutical formulations of n-substituted indenoisoquinoline compounds are described. Also described are processes for preparing n-substituted indenoisoquinoline compounds.
11/13/14
20140336154
Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use
Benzopyran and benzoxepin compounds of formulas i and ii, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of pi3k, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of formulas i and ii for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
11/13/14
20140336146
Novel galectoside inhibitors of galectins
The present invention relates to novel compounds prepared from readily accessible 3-o-propargyl-d-galactopyranoside derivatives and having an effect as i.a., galectin inhibitors, the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to ligands in a mammal, wherein said galectin is preferably a galectin-3. The novel compounds are defined by the general formula (i)..
11/13/14
20140335566
Mobile vessel or carrier for the manufacturing production and purification of biologics
Embodiments described herein relate to mobile biologics production systems that can be transported to a site where a production of biologics is required, and is operable to produce the biologics on-site on demand. A mobile biologics production system can include a mobile carrier configured to be trailered to a biologics production location.
11/13/14
20140335552
Method and apparatus for detecting cancer in mammals
The invention provides a method and apparatus for detecting cancer using the measurement of acute-phase proteins (apps) and the measurement of thymidine kinase activiy level in body fluids. An index is calculated based on the measured data and compared with a pre-established reference that allows a pratitioner to determine a high probabilty that a patient is a carrier of cancer..
11/13/14
20140335534
Method and system for identifying a biomarker indicative of health condition
By designing a retrogression-progression model in combination with oral microbial community analysis, the present invention provides a method of identifying a biomarker indicative of a subject mammal's condition, wherein the condition is selected from presence of the first disease, severity of the first disease, sensitivity to the first disease, and combinations thereof. The present invention further provides a computer-aided system of identifying a biomarker indicative of a subject mammal's condition..
11/13/14
20140335529
Method of tumor screening
A method for tumor screening using urine of a mammal, the method includes obtaining a total urine nucleic acid (e.g., dna) from a urine sample of a mammal, extracting a high molecular weight urine nucleic acid (above 1000 bp) by contacting the total urine nucleic acid with an adsorbent in the presence of a buffer which promotes binding of the high molecular weight urine nucleic acid to the adsorbent, replacing the buffer which promotes binding of the high molecular weight urine nucleic acid with a buffer which promotes binding of the low molecular weight urine nucleic acid to the adsorbent, extracting the low molecular weight urine nucleic acid by contacting with the adsorbent, eluting the low molecular weight urine nucleic acid, and assaying the low molecular weight urine nucleic acid for a presence or absence of a gene sequence specific to a certain type of tumor.. .
11/13/14
20140335207
Deep topical systemic nitric oxide therapy apparatus and method
A topical mixture that produces nitric oxide and a method for using the topical mixture to increase the vasodilation of a bloodstream via transdermal absorption of the nitric oxide. The nitric oxide can then affect subcutaneous tissues.
11/13/14
20140335193
Controlled-release injectable microparticle
The invention relates to a controlled-release injectable microparticle comprising a polyvinyl alcohol polymer and one or more hormones, in particular progesterone. Said microparticle induces estrus in female mammals after a single application.
11/13/14
20140335147
Regeneration aid for bone defects
The invention relates to a molded part for supporting bone regeneration, in particular the regeneration of a jawbone or jawbone section in a mammal, preferably a human, wherein the molded part is suitable for applying to the jawbone and has a coating having a composition comprising at least one collagen, a granular material, and hyaluronic acid or a hyaluronic acid derivative. The invention further relates to a granular material that can be used in the coating, to a method for producing the granular material, and to the use of the molded part..
11/13/14
20140335144
Tissue scaffolds derived from forestomach extracellular matrix
The present invention pertains to the development of extracellular matrix (ecm) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction.
11/13/14
20140335128
Adenoviral vector-based malaria vaccines
The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a p.
11/13/14
20140335107
Anti-cd79b antibodies and immunoconjugates and methods of use
The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.. .
11/13/14
20140335094
Mammalian cytokines; related reagents and methods
Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided..
11/13/14
20140335088
Antibodies and vaccines for use in therapeutic and diagnostic methods for alpha-synuclein-related disorders
Methods of treating or delaying onset of a neurodegenerative disorder with α-synuclein pathology in an individual comprise administering an antibody which is produced from a stabilized soluble α-synuclein oligomer and capable of binding a stabilized soluble α-synuclein oligomer, the stabilized soluble α-synuclein oligomer having a lower formation rate to a non-soluble aggregated form than a non-stabilized soluble oligomer of the α-synuclein. The antibody has been collected from a non-human animal to which stabilized soluble α-synuclein oligomer had been administered or has been produced by hybridoma technology, phage display, ribosome display, mammalian cell display or bacterial display, and the disorder with α-synuclein pathology is characterized by deposition of lewy bodies and lewy neurites or is selected from the group consisting of parkinson's disease (pd), dementia with lewy bodies (dlb), the lewy body variant of alzheimer's disease, and multiple system atrophy (msa)..
11/13/14
20140335015
Nanoparticles comprising metallic and hafnium oxide materials, preparation and uses thereof
The present invention relates to novel nanoparticles which can be advantageously used in the health sector as diagnostic and/or therapeutic agents. Nanoparticles of the invention comprise a metallic material at least partly covered with an hafnium oxide material or embedded therein.
11/06/14
20140331340
Methods and compositions for generating a mouse
Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable of transmitting the donor cell dna.. .
11/06/14
20140330317
Method, system, and apparatus for mammalian bony segment stabilization
Embodiments of bony region stabilization are described generally herein. Other embodiments may be described and claimed..
11/06/14
20140330274
Implantable device with pivotable fastener and self-adjusting set screw
An intramedullary device to repair a bone in a mammalian body and comprising an elongate nail having a stem and a head. The head is provided with a transverse aperture adapted to receive a fastener.
11/06/14
20140330014
Imidazotriazinone compounds
The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of pde9 associated diseases or disorders in mammals, including humans..
11/06/14
20140329900
Small molecule inhibitors of stat3 with anti-tumor activity
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of stat3 signaling, stat3 dimerization, stat3-dna binding, stat5-dna binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, nsc 74859 (s31-201), nsc 42067, nsc 59263, nsc 75912, nsc 11421, nsc 91529, nsc 263435, and pharmaceutically acceptable salts and analogs of the foregoing.
11/06/14
20140329872
Treatment of hypertension and/or prevention or treatment of heart failure in a mammal receiving anti-coagulant therapy
The invention relates to methods and pharmaceutical compositions for treating hypertension and/or preventing or treating heart failure in a mammal receiving anti-coagulant therapy using compound(s) which are therapeutically effective but do not impact the pharmacokinetic or the pharmacodynamic effect(s) of the anti-coagulant, such as warfarin.. .
11/06/14
20140329856
Method of treating pain
The instant application discloses methods of treating, reducing, or preventing pain in a mammal, which may include administering a compound capable of modulating a transient receptor potential channel. In one aspect, the trp channel may be trpc4.
11/06/14
20140329843
High dose buprenorphine compositions and use as analgesic
The present disclosure relates to a method of providing prolonged analgesia to a mammal in need thereof. Specifically, the current disclosure is directed to a method of treating pain in a mammal for a prolonged period of time using a single high dose of a buprenorphine formulation..
11/06/14
20140329811
Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases
The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-hete synthesizing enzyme inhibitor or a 20-hete antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (adpkd), autosomal recessive polycystic kidney disease (arpkd), arpkd associated congenital hepatic fibrosis, arpkd associated caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-hete synthesizing enzyme inhibitor or a 20-hete antagonist to the mammal in an amount sufficient to prevent or treat the disease..
11/06/14
20140329780
Inhibitor of colonisation of mucosa
The present invention relates in the first aspect to the use of aurintricarboxylic acids, derivatives, oligo- or polymers or salts, for inhibiting adherence and colonisation of microorganisms, like bacteria, on surfaces, in particular for use in mammals. That is, it has been recognized that aurintricarboxylic acids and derivatives thereof are suitable for inhibiting adherence and colonisation of mucosa, in particular, nasal mucosa.
11/06/14
20140329776
Mitochondria-targeted antioxidants for treatment of age-related brain disorders
A method for providing to a mammal a neuroprotective effect against a brain pathology that is associated with reactive oxygen species originating from mitochondria (mros). The method includes the step of administering to the mammal an skq mitochondria-targeted antioxidant in an amount effective to provide said neuroprotective effect.
11/06/14
20140329753
Angiogenic active lytic peptides
This invention relates to novel synthetic lytic peptide fragments of full-length peptides with the capacity to modulate angiogenic activity in mammals. The invention also relates to the use of such peptides in pharmaceutical compositions and in methods for treating diseases or disorders that are associated with angiogenic activity..
11/06/14
20140329675
Honeybee repellents and uses thereof
The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents.. .
11/06/14
20140329674
Honeybee repellents and uses thereof
The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents.. .
11/06/14
20140329279
Compositions for cell culture and methods of using the same
Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective in reduction of acidic species variants on recombinant antibodies. The demonstrated reduction in acidic species through the use of bioflavonoids, facilitates the manufacturing of a less heterogeneous product with potential improvements in antibody structure and function..
11/06/14
20140328946
Antimicrobial solutions containing dichloride monoxide and methods of making and using the same
Methods and products are provided for treating a wound or infection in a mammal or disinfecting a surface with a hypochlorous acid solution that has been activated by a catalyst. Additionally provided is a process for preparing an antimicrobial product that produces an activated hypochlorous acid solution for use as an antimicrobial..
11/06/14
20140328937
Drug delivery systems and use thereof
The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-vascular endothelial growth factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal.
11/06/14
20140328897
Charge triggering of self-organized nanoparticles
The present application discloses a nanoparticle comprising compounds of the formula a-b-c(-d), wherein a designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; b designates a cleavable linker; c designates an anionic moiety having a net charge of at least −2 at ph 6.0; and d, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue; and wherein the average net charge of the compounds is at least −1 at ph 6.0. The application also discloses the individual compounds of the formula a-b-c(-d) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal..
11/06/14
20140328873
Norovirus immunogens and related materials and methods
The inventors have successfully developed a recombinant vesicular stomatitis virus which expresses the major capsid protein of human norovirus. Infection of mammalian cells with the recombinant vesicular stomatitis virus resulted in production of high level of human norovirus virus-like particles.
11/06/14
20140328846
Anti-properdin antibodies
A method of inhibiting alternative complement pathway activation in a mammal includes administering an amount of an antibody and/or fragment thereof that specifically binds to an epitope of the n terminus end of properdin effective to the inhibit alternative complement pathway in the subject.. .
11/06/14
20140328825
Making and using in vitro-synthesized ssrna for introducing into mammalian cells to induce a biological or biochemical effect
The present invention relates to compositions, kits and methods for making and using rna compositions comprising in vitro-synthesized ssrna inducing a biological or biochemical effect in a mammalian cell or organism into which the rna composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell.
11/06/14
20140328810
Cell-based therapy for the pulmonary system
Cell based therapy comprises administration to the lung by injection into the blood system of viable, mammalian cells effective for alleviating or inhibiting pulmonary disorders. The cells may express a therapeutic transgene or the cells may be therapeutic in their own right by inducing regenerative effects..
11/06/14
20140328796
4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
The variables r1-r9, r16, r18, r19, n, m, n, m, and z are defined herein. Certain compounds of formula i are useful as antiviral agents.
11/06/14
20140328792
Methods and compositions for treating and preventing viral infections
A method of treating or preventing a systemic viral infection in a mammal by administering a pharmaceutically acceptable composition selected from the group consisting of squalamine, an active isomer thereof, and an active analogue thereof, via a dosing regimen that delivers effective antiviral concentrations of squalamine. Also compositions for achieving the systemic antiviral effect..
11/06/14
20140328750
Antibodies reactive with b7-h3 and uses thereof
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human b7-h3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized b7-h3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers..
10/30/14
20140324138
Wirelessly-powered illumination of biological tissue
In exemplary implementations of this invention, an implant device is wholly or partially implanted in a mammal. The implant device includes an antenna, circuitry, a supercapacitor, one or more light sources, and an array of optical fibers or light guides.
10/30/14
20140324119
Transcutaneous electrical nerve stimulation and method using same
The present disclosure relates to an apparatus and associated methods to produce analgesia in a mammal by providing an electrical nerve stimulus utilizing a pulsed input of low level electrical current, wherein the level of current is measurable with the measurements utilized to at least adjust the strength of the current according to selected parameters. Additionally, the use of magnets to produce a magnetic field to further control chronic and acute pain.
10/30/14
20140323924
Targeted optogenetic neuromodulation for treatment of clinical conditions
Disclosed are methods and systems and methods for methods for neuromodulation of deep-brain and other neural targets in mammals using optogenetics to treat clinical conditions or achievement of a physiological state. The neuromodulation can produce acute or long-term effects.
10/30/14
20140323860
Imaging probe with combined ultrasound and optical means of imaging
The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (ivus) and optical imaging methods such as optical coherence tomography (oct) and to accurate co-registering of images obtained from ultrasound image signals and optical image signals during scanning a region of interest..
10/30/14
20140323532
Amide compounds, compositions and uses thereof
Where a, b, w, x′, l, r1, r3, r4b, and m′ are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others..
10/30/14
20140323513
Chemotherapeutic compositions and methods for treating human gliomas
Disclosed are compound for targeting chemotherapeutic agents to mammalian mitochondria. Also disclosed are monoamine oxidase-specific compositions, and methods of using them for the selective therapy of mammalian cancers, and in particular, in the treatment of human gliomas.
10/30/14
20140323472
Methods and compositions for the delivery of a therapeutic agent
The present invention provides a liquid pharmaceutical composition comprising a therapeutic agent and an alkoxy-polyethylene glycol, for example, methoxy-polyethylene glycol, for administration of the therapeutic agent to the mammal. The compositions can be applied to a membrane, for example, a nasal membrane during intranasal administration.
10/30/14
20140323455
Methods for preserving photoreceptor cell viability following retinal detachment
Provided are methods for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering a hydrophilic bile acid (e.g., udca or tudca) to a mammal having an eye with a detached retina.
10/30/14
20140323438
Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (i), wherein r1, r2, r3, and r4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal..
10/30/14
20140323398
Ultra-concentrated rapid-acting insulin analogue formulations
A pharmaceutical formulation comprises insulin having a variant insulin b-chain polypeptide containing an ortho-monofluoro-phenylalanine substitution at position b24 in combination with a substitution of an amino acid containing an acidic side chain at position b10, allowing the insulin to be present at a concentration of between 0.6 mm and 3.0 mm. The formulation may optionally be devoid of zinc.
10/30/14
20140323190
Systems and methods for enhancing cognition
The disclosure is directed to cognitive training exercise adapted to train working memory systems in mammals in an intuitive, engaging, and adaptively challenging way to enhance cognition. Exercises engage users in the task of first seeing a grid with angled “bumpers” placed in various places throughout the grid.


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