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Malignant Cells patents



      
           
This page is updated frequently with new Malignant Cells-related patent applications. Subscribe to the Malignant Cells RSS feed to automatically get the update: related Malignant RSS feeds. RSS updates for this page: Malignant Cells RSS RSS


Date/App# patent app List of recent Malignant Cells-related patents
06/04/15
20150152175
 Therapies for cancer using rlip76 patent thumbnailTherapies for cancer using rlip76
The present invention is a composition identified as a region of rala binding protein 1, wherein the region neighbors a membrane-associated portion of the rala binding protein 1, reduces transport activity and membrane association of the rala binding protein 1 and kills cells undergoing uncontrolled cell growth in a subject that has cells undergoing uncontrolled cell growth. The region is used to generate medicines that kill malignant cells and tumorigenic cells.
Board Of Regents, The University Of Texas System
04/23/15
20150110774
 S100 protein inhibitors for treating leukemia patent thumbnailS100 protein inhibitors for treating leukemia
The present invention relates to a compound, composition and method for reducing or inhibiting the differentiation or development of progenitor blood cells into malignant cells, leukemia cells or physiologically pathological cells. Particularly, the invention describes the use of inhibitors of s100 proteins, including myeloid related proteins.
Universite Laval
04/09/15
20150098924
 Method for ex-vivo purging in autologous transplantation patent thumbnailMethod for ex-vivo purging in autologous transplantation
The present invention concerns a new method for ex-vivo purging of cells in autologous transplantation, wherein the sample of taken cells is treated with a sufficient amount of a multimeric form of the soluble portion of fasl to kill malignant cells without substantially affecting viability of cells to be transplanted. Autologous stem cell transplantation (asct) following high-dose chemotherapy with or without radiotherapy has become the standard therapy for the majority of patients with large-cell lymphomas, multiple myeloma, and refractory/recidivating hodgkin's disease.
Topotarget Switzerland Sa
04/02/15
20150094353
 Inhibitors targeting the dna-binding domain of human stat3 for treatment of metastatic cancers patent thumbnailInhibitors targeting the dna-binding domain of human stat3 for treatment of metastatic cancers
The present invention provides stat3 inhibitors which preferentially suppress proliferation of cancer over non-cancer cells and inhibit migration and invasion of malignant cells. The inhibitors of the present invention selectively inhibit stat3 binding to dna without affecting the activation and dimerization of stat3.
03/12/15
20150072891
 Method for detection of l523s expression in biological samples patent thumbnailMethod for detection of l523s expression in biological samples
The present invention discloses methods for differentiating between normal or reactive cells and malignant cells in biological samples comprising: exposing the biological sample to an antibody to l523s protein and detecting the presence of the antibody bound to l523s protein within the malignant cells, in embodiments, such methods may further comprise: exposing the biological sample to an antibody to a second protein that is a marker of cell lineage and detecting the presence of the antibody to the second protein within cells corresponding to a particular ceil lineage and/or may comprise: exposing the biological sample to an antibody to a third protein which is a marker of cells that are normal or reactive and detecting the presence of the antibody to the third protein within cells that are normal or reactive.. .
Dako Denmark A/s
03/12/15
20150071918
 Peptides for the treatment of cancer patent thumbnailPeptides for the treatment of cancer
The invention relates to novel cyclic compounds (cyclic peptides), linkers useful as beta-turn promoters in cyclic peptides, and methods for treatment of malignant cells in vitro or in vivo using one or more linear and cyclic peptides. The peptides can act as integrin interaction inhibitors and may be used in the treatment of cancers as monotherapies or in combination with other anti-cancer agents, such as proteasome inhibitors, inhibitors of autophagy, alkylating agents, mek inhibitors, fak/pyk2 inhibitors, and egfr inhibitors.
University Of South Florida
02/05/15
20150037287
 Method of treating a malignancy in a subject and a pharmaceutical composition for use in same patent thumbnailMethod of treating a malignancy in a subject and a pharmaceutical composition for use in same
There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the picornaviridae family.
Viralytics Limited
01/01/15
20150004642
 Method for separating aggregates of malignant cells and aggregates from stromal cells of a malignant tumour tissue sample patent thumbnailMethod for separating aggregates of malignant cells and aggregates from stromal cells of a malignant tumour tissue sample
An ex vivo malignant tumor tissue sample is cleaned, comminuted, suspended in culture medium, subjected to a treatment with collagenase and the collagenase decomposition product is centrifuged. The pellet obtained is re-suspended in culture medium by an absorption instrument, is absorbed and returned several times and transferred to a culture vessel.
Flacod Gmbh
12/11/14
20140363373
 Method for combined imaging and treating organs and tissues patent thumbnailMethod for combined imaging and treating organs and tissues
The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized, fully human), partial antibody, fab fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell.
11/27/14
20140348805
 High affinity t cell receptor and use thereof patent thumbnailHigh affinity t cell receptor and use thereof
The present invention is directed to a high affinity t cell receptor (tcr) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same, a t cell expressing said tcr, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.. .
11/20/14
20140341338

Mammography-apparatus, paddle and measuring a contact area between a breast and the mammography-apparatus


Mammography-apparatus for detecting malignant cells in a breast, comprising an x-ray source and an x-ray detector that cooperates with the x-ray source for providing an x-ray image of said breast, and further comprising a paddle for flattening the breast by pressing it against said x-ray detector, and comprising a contact area measuring device for measuring a contact area between the breast and the paddle, wherein the contact area measuring device is embodied with at least a first laminate of an electrically insulating material and an electrically low resistance material, which first laminate is provided on a side of the paddle facing the breast, and wherein the electrically low resistance material is sandwiched between the paddle and the insulating material.. .
11/06/14
20140329900

Small molecule inhibitors of stat3 with anti-tumor activity


The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of stat3 signaling, stat3 dimerization, stat3-dna binding, stat5-dna binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, nsc 74859 (s31-201), nsc 42067, nsc 59263, nsc 75912, nsc 11421, nsc 91529, nsc 263435, and pharmaceutically acceptable salts and analogs of the foregoing.
10/16/14
20140308301

Cd44 monoclonal antibody for the treatment of b-cell chronic lymphocytic leukemia and other hematological malignancies


Compositions including an antibody specific for cd44 are provided. These antibodies specifically bind to hematologic malignant cells.
10/09/14
20140303134

Platinum compounds that inhibit constitutive stat3 signaling and induce cell cycle arrest and apoptosis of malignant cells


The subject invention concerns a compound and compositions having activity as an inhibitor of stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula i, formula ii, or formula iii.
09/25/14
20140288162

Methods, compositions and screens for therapeutics for the treatment of synovial sarcoma


Methods and compositions are provided for treating human synovial sarcoma (ss). Also provided are screens to identify therapeutics for the treatment of synovial sarcoma.
09/18/14
20140275235

Treatment of proliferative disorders


The present invention relates to a method and composition for treating safely (in a non-toxic way) disease or disorder exhibiting excessive cellular proliferation comprising administering to a patient needing such treatment, a composition comprising curcumin (derived from turmeric), epigallocatechin-3-gallate (egcg, enriched in green tea), glucosinolates (enriched in cruciferous vegetables) and/or derivatives thereof, such as sulforaphane (sfn), alone or combined with a ketogenic diet or a modified ketogenic diet. Also the current invention relates to a composition comprising medium chain triglycerides, epigallocatechin-3-gallate, curcumin, compositions comprising glucosinolates and/or derivatives thereof, such as sulforaphane (sfn).
07/24/14
20140206836

Novel n- and c-terminal substituted antagonistic analogs of gh-rh


There is provided a novel series of synthetic analogs of hgh-rh(1-29)nh2 (seq id no: 1) and hgh-rh(1-30)nh2. Of particular interest are those carrying phac, n-me-aib, dca, ac-ada, fer, ac-amc, me-nh-sub, phac-ada, ac-ada-d-phe, ac-ada-phe, dca-ada, dca-amc, nac-ada, ada-ada, or ch3—(ch2)10—co-ada, at the n-terminus and β-ala, amc, apa, ada, ae2a, ae4p, ε-lys(α-nh2), agm, lys(oct) or ahx, at the c-terminus.
07/24/14
20140205648

Methods for the in situ treatment of bone cancer


The present invention relates to methods for in situ treatment of malignant cells from a cancer associated with bone. In one method, the treatment is for a primary cancer and entails positioning an implant containing and/or coated with at least one active agent for treating malignant cells directly in/on or indirectly among/near (e.g., by placing the implant in an area immediately proximal to) a site containing the malignant cells.
06/26/14
20140179693

Methods for treating vascular leak syndrome


Disclosed are methods for treating vascular leak syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, inflammatory bowel disease.
06/05/14
20140154248

Recombinant immunotoxin targeting mesothelin


Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents.
03/06/14
20140066458

Methods for treating vascular leak syndrome


Disclosed are methods for treating vascular leak syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel disease.
03/06/14
20140065246

Intracellular calcium modulation for cancer treatment


Tumor cells exhibit consistent abnormalities in calcium regulation. The present disclosure teaches methods by which such differences are exploited to induce apoptosis selectively in tumor/cancer cells while sparing normal cells.
03/06/14
20140065207

Therapies for cancer using rlip76


The present invention is a composition identified as a region of rala binding protein 1, wherein the region neighbors a membrane-associated portion of the rala binding protein 1, reduces transport activity and membrane association of the rala binding protein 1 and kills cells undergoing uncontrolled cell growth in a subject that has cells undergoing uncontrolled cell growth. The region is used to generate medicines that kill malignant cells and tumorigenic cells.
01/30/14
20140030260

Methods and compositions to eliminate chronic lymphocytic leukemia and other hematologic malignant cells in stromal microenvironment for cancer therapy


The present invention regards compositions and methods for treating chronic lymphocytic leukemia in the in vivo tissue environment using selenium-containing compositions. In particular aspects, a selenium-comprising compound is administered to an individual wherein the cll cells are in a stromal cell environment, wherein stromal factors modulate the selenium comprising compound to enhance its activity..
01/16/14
20140017194

Compositions and methods of use of phorbol esters


Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of cytopathic diseases. Cytopathic diseases may be caused by a variety means such as viral infections like hiv and aids, or the development of neoplasms in a mammalian subject.
12/26/13
20130345231

Anticancer therapeutic agents


The invention described herein pertains to anticancer therapeutic agents that exhibit preferential cytotoxicity to malignant cells that express a cancer specific isoform of proliferating cell nuclear antigen (capcna) compared to cytotoxicity to comparable non-malignant cells, pharmaceutical compositions comprising the agents, and their use in cancer therapy.. .
12/12/13
20130331386

Methods for treating vascular leak syndrome


Disclosed are methods for treating vascular leak syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel disease.
12/12/13
20130330742

Assay for colon and other cancers in humans


The present invention is concerned with a novel antigen associated with human tumors, including carcinomas of the colon, pancreas, and lung, as well as novel monoclonal antibodies which binds strongly to said antigen. The antibodies bind to normal human cells to a much lesser degree than to tumor cells.
11/21/13
20130310824

System for detecting, actively targeting and selectively treating malignant cells in human body by non-invasive procedure


The embodiments herein provide a system and method for detecting, actively targeting and selectively treating the biological targets in a human body by a non-invasive procedure. The system comprises an electromagnetic inductor supported at a predetermined height and rotated to generate a high frequency magnetic field.
11/21/13
20130310263

Diagnosing cancer using genomic sequencing


Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free dna from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced.
11/07/13
20130296198

Diagnostic tests using gene expression ratios


The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from cell or tissue samples, such as cancer cell or tissue samples. The invention also provides sets of genes that are expressed differentially in normal and cancer lung cells and tissues.
10/10/13
20130266591

Use of tri-substituted glycerol compounds for the treatment of hematological malignancies


The present invention relates to the use of a tri-substituted glycerol compound for the manufacture of a medicament for the treatment of hematological malignancies. The invention also refers to a kit-of-parts comprising such a medicament.
10/03/13
20130261055

Novel n- and c- terminal substituted antagonistic analogs of gh-rh


There is provided a novel series of synthetic analogs of hgh-rh(1-29)nh2 (seq id no: 96) and hgh-rh(1-30)nh2. Of particular interest are those carrying phac, n-me-aib, dca, ac-ada, fer, ac-amc, me-nh-sub, phac-ada, ac-ada-d-phe, ac-ada-phe, dca-ada, dca-amc, nac-ada, ada-ada, or ch3—(ch2)10—co-ada, at the n-terminus and β-ala, amc, apa, ada, ae2a, ae4p, ε-lys(α-nh2), agm, lys(oct) or ahx, at the c-terminus.
09/26/13
20130251732

Targeting of cyp1b1 in the treatment of head and neck cancer and lung cancer


Methods for inhibiting the motility or proliferation of premalignant and malignant cells are provided. Methods for treating a malignancy of the head and neck and for treating a malignancy of the lung are also provided..
08/22/13
20130217757

Oncolytic measles virus


The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein..
08/22/13
20130217594

Methods for screening compounds for capability to inhibit premalignant squamous epithelial cell progression to a malignant state


Methods for screening compounds for their capability to inhibit cyp1b1-mediated proliferation and motility of and/or to reverse estrogen-induced reduction in apoptosis of premalignant or malignant cells are provided. Kits for practicing the screening methods are also provided..
06/27/13
20130164330

Methods and compositions for treatment of hematologic cancers


The present invention relates to oncolytic picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed picornavirus such as coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation..
06/13/13
20130149288

Methods of generating oligodendrocytes and cell populations comprising same


A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (mscs) with at least one exogenous mirna having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of seq id nos: 15-19 and 27-35, thereby generating the population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells.
01/31/13
20130028373

Mammography-apparatus


Mammography-apparatus for detecting malignant cells in a breast comprising an x-ray source and an x-ray detector that cooperates with the x-ray source for providing an x-ray image of said breast, and further comprising a paddle for flattening the breast by pressing it against said x-ray detector, wherein at least one sensor is applied for measuring a parameter that is used for determining the pressure at which the paddle compresses the breast, and wherein a control system is provided which controls the actuation of the paddle depending on the pressure that is applied to the breast, wherein there is a contact area measuring unit for measuring the contact area between the breast and the paddle.. .


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Malignant Cells topics: Malignant Cells, Malignant Cell, Proliferation, Premalignant, Recombinant, Stem Cells, Endogenous, Malignancy, Proliferative Disorder, Antagonist, Amino Acid, Growth Hormone, Proliferative, Amino Acids, Lung Cancer

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