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Malaria patents



      
           
This page is updated frequently with new Malaria-related patent applications. Subscribe to the Malaria RSS feed to automatically get the update: related Malaria RSS feeds. RSS updates for this page: Malaria RSS RSS


Date/App# patent app List of recent Malaria-related patents
07/17/14
20140200226
 Anti-malarial compounds from marine natural products patent thumbnailAnti-malarial compounds from marine natural products
Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.. .
07/10/14
20140194640
 Quaternary n-(halomethyl) ammonium salts as therapeutic agents patent thumbnailQuaternary n-(halomethyl) ammonium salts as therapeutic agents
The use of quaternary halogenated ammonium salts for treating leishmaniasis infections and other parasitic diseases is described. Although there have been previous reports in which quaternary ammonium salts are used as antimalarial, antifungal, and antileishmanial compounds, the use of such salts containing a halogenated n-methyl substituent as a therapeutic agent against leishmaniasis had not been reported.
07/10/14
20140193493
 Solid dosage forms of oleyl phosphocholine patent thumbnailSolid dosage forms of oleyl phosphocholine
The present invention relates to solid dosage forms of oleyl phosphocholine (c18:1-pc), or olpc, for oral administration. Further, the present invention relates to methods for the preparation of the present solid dosage forms and the use thereof as a medicament and especially a medicament for treatment of parasitic diseases, such as leishmaniasis, chagas and malaria, and cancer both in humans and animals.
07/03/14
20140186402
 Blood stage malaria vaccine patent thumbnailBlood stage malaria vaccine
An immunogenic composition for use as a blood-stage malaria vaccine, a method of producing the immunogenic composition and a method of treatment of malaria are provided. The immunogenic composition includes isolated or purified merozoites, or red blood cells infected with merozoites, treated with centanamycin or tafuramycin a.
06/26/14
20140179772
 Anti-malarial pharmaceutical composition patent thumbnailAnti-malarial pharmaceutical composition
The invention provides pharmaceutical compositions for the treatment and prophylaxis of malaria, comprising artemether and a medium chain triglyceride formulated for transmucosal sublingual, buccal or nasal delivery, especially by a spray. Also provided are delivery devices containing the compositions..
06/19/14
20140171438
 Hybrid compounds and methods of making and using the same patent thumbnailHybrid compounds and methods of making and using the same
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a mycobacterium infection; killing or inhibiting the growth of a plasmodium species; inhibiting the growth of a mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.. .
06/05/14
20140155367
 Compounds and compositions for the treatment of parasitic diseases patent thumbnailCompounds and compositions for the treatment of parasitic diseases
Or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a plasmodium parasite, such as malaria..
06/05/14
20140154289
 Attenuated plasmodium with deactivated hmgb2 gene, as vaccine patent thumbnailAttenuated plasmodium with deactivated hmgb2 gene, as vaccine
The present invention relates to novel compositions and methods for immunizing a host against malaria using a plasmodium parasite genetically attenuated via the inactivation of the function of the hmgb2 gene.. .
05/29/14
20140147414
 Compositions and methods for treatment of intracellular damage patent thumbnailCompositions and methods for treatment of intracellular damage
Pre-implantation factor (pif) may be used to treat intracellular damage. Aspects of the invention are directed to a method of treating intracellular damage comprising administering pif to a subject in need thereof.
05/15/14
20140135360
 Aryl derivatives and uses thereof patent thumbnailAryl derivatives and uses thereof
The present invention relates to antimalarial compounds and their use against protozoa of the genus plasmodium, including drug-resistant plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds..
05/15/14
20140135320
Heteroaryl derivatives and uses thereof
The present invention relates to antimalarial compounds and their use against protozoa of the genus plasmodium, including drug-resistant plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds..
05/15/14
20140134657
Screening methods for identifying plasmodium proteases inhibitors
The invention relates to the field of parasitology. Methods and peptidic substrate for screening and identifying inhibitors of plasmodium are described.
05/08/14
20140128423
Acridone compounds
A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents.
05/08/14
20140128408
Hdac inhibitors and therapeutic methods using the same
Histone deacetylases inhibitors (hdacis) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of hdac provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed..
05/01/14
20140121238
Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.. .
05/01/14
20140120633
Devices and methods for detection and quantification of immunological proteins, pathogenic and microbial agents and cells
The present invention provides a method and microfluidic immunoassay pscreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, rna, rna fragments, functionalized magnetic micro-beads specific to cd4+, cd8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays..
05/01/14
20140120138
Pharmaceutical compositions comprising attenuated plasmodium sporozoites and glycolipid adjuvants
Disclosed herein are pharmaceutical compositions comprising plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range plasmodium and analogues of α-galactosylceramide (α-galcer), a ligand for natural killer t (nkt) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria.
04/24/14
20140112930
Methods for treating or preventing malaria by administering an antibody that specifically binds angiopoietin-2 (ang-2)
The present invention provides methods for treating or preventing malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody that specifically binds human angiopoietin-2 (ang-2).. .
04/10/14
20140100240
Natural product derivatives with antiprotozoal activity
The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.. .
04/10/14
20140100198
Enzyme inhibiting compounds and methods
The invention provides compounds, compositions, and methods for studying the rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria.
04/10/14
20140100178
Composition and methods for site-specific drug delivery to treat malaria and other liver diseases
A system for selectively delivering drugs to target tissues is provided. The system includes a drug-linker-saccharide-drug conjugate (d-l-a-d1).
04/03/14
20140093530
Malaria vaccines
The present invention relates to a synthetic antigenic sequence which represents a combination of epitope-containing sequences from the highly polymorphic block 2 repeat region of k1-type plasmodium falciparum merozite surface antigen (msp1) and fusion proteins containing that sequence in combination with additional epitope-containing sequences capable of inducing antibody and cellular immune responses to p. Falciparum antigens.
03/27/14
20140088082
Inhibitors of the plasmodial surface anion channel as antimalarials
Or a pharmaceutically acceptable salt thereof, wherein r1 to r7 are as described herein.. .
03/27/14
20140087399
Assay method for peptide specific t-cells
A method of assaying for peptide-specific t-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon-y produced by t-cells that have been pre-sensitised to the peptide. The assay method is quick and cheap and is expected to be useful for the study of various disease states including hepatitis b, hepatitis c, tuberculosis, malaria, hiv and influenza..
03/20/14
20140079736
Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula (i): q-y—r1—r2 (i), wherein q, y, r1, and r2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided.
03/13/14
20140072663
Compositions and methods for treating multi-drug resistant malaria
A method is provided for treating an individual for a malarial infection, in particular drug-resistant species of plasmodium, including administering to the individual in need of such treatment a composition comprising an extract containing an effective amount of one or more anti-malarial di- or tri-terpene compounds. Potent and effective extracts containing the anti-malarial compounds can be derived from luo han fruit and stevia leaves, including combinations of the same, for the purpose of treating and preventing malaria in an inexpensive manner from readily available commodities.
02/20/14
20140050696
Novel bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention.
02/06/14
20140039240
Applying torque to paramagnetic structures in bodies using dual magnetic fields
Techniques for applying torque to microscopic paramagnetic structures in a body includes exposing a body simultaneously to a first magnetic field oscillating at a first frequency in a first direction and a different second magnetic field oscillating at a second frequency in a second direction. The body includes a plurality of microscopic paramagnetic structures for which magnetic susceptibility to the first magnetic field is different from magnetic susceptibility to the second magnetic field.
02/06/14
20140037577
Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing diindolylmethane-related indoles. Additive and synergistic interaction of diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections.
01/09/14
20140011830
Artemisinin-based combination therapy for treating parasitic mediated disease
The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved artemisinin combination therapy, known as tri-act. The improved act therapy includes administering a combination of three drugs.
01/09/14
20140010816
Treatment and prevention of malaria
The present invention relates to polypeptides from plasmodium and polynucleotides encoding the polypeptides. The invention further relates to compositions comprising the polypeptides and their use in the treatment and prevention of malaria..
12/05/13
20130324727
Anti-folate antimalarials with dual-binding modes and their preparation
The present invention is anti-folate antimalarials with dual-binding modes of the general formula (i) [refer to structure in the abstract] wherein r1 and r2 which may be the same or different are independently selected from methyl or ethyl or alkyl-phenyl, r3 is independently hydrogen, halide, lower alkyl substituted with ester, carboxylic, amide, and ether. Linker is x(ch2)ny wherein x and y which may be the same or different are independently selected from oxygen, carbon, nitrogen, substituted phenyl where n is an integer from 1 to 2-6, or pharmaceutically acceptable salts therefore.
12/05/13
20130323276
Malaria vaccines based on pre-erythrocytic antigens from p. falciparum
The present invention relates to polypeptides or fragments thereof for use as malaria vaccines. It also relates to nucleic acid molecules coding for the polypeptides of the invention.
11/21/13
20130310348
Quinoline derivatives and uses thereof
This disclosure provides a new class of compounds referred to as “reversed chloroquines” (rcqs), which are highly effective against cqr and cqs malaria parasites. Rcqs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a cqr reversal moiety.
11/07/13
20130296230
Method for treating malaria, method for killing malaria parasite, and use of the methods
A method of the present invention for treating malaria includes the step of administering, to a human or an animal, a therapeutically effective amount of drug for suppressing calcium ion exit from an intracellular organelle of the malaria parasite to an outside of the intracellular organelle and/or calcium ion entry from an outside of a cell of the malaria parasite into the cell.. .
11/07/13
20130295138
Roadmap for controlling malaria
Embodiments of the present invention concern methods of preventing malaria in a target population of humans comprising: uniformly administering a therapeutically effective amount of a live low dose malaria vaccine to each individual within the target population on each of two or three consecutive days. The methods include using plasmodium infected mosquitoes to inject plasmodium into individuals through mosquito bites..
10/24/13
20130281484
Hdac inhibitors and therapeutic methods of using same
Histone deacetylases inhibitors (hdacis) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of hdac provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed..
10/24/13
20130281403
Compounds and compositions for the treatment of parasitic diseases
The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent malaria.. .
10/17/13
20130274542
Medical device for treatment of human parasitism and of related diseases
The use of a magnetic field for eliminating the malaria parasite is disclosed. Furthermore, herein described is an electromedical device for the treatment of human parasitosis, and especially the malaria parasite, comprising a plurality of coils (10) defining a cage (s) for accommodating the patient, the coils being connected to a drive circuit for subjecting the patient to a substantially uniform magnetic field..
10/17/13
20130273112
Consensus antigen constructs and vaccines made therefrom, and methods of using the same to treat malaria
Provided herein is consensus amino acid sequences of p. Falciparum (p.f.) proteins and their encoding sequences, as well as expression constructs expressing the sequences.
10/17/13
20130273086
Compositions and methods for treatment, research and therapeutic applications for malaria
The present invention provides anti-plasmodium immunogenic compositions comprising evp1 (pfd0495c) or an antigenic portion thereof, as well as methods of immunizing against malaria employing these compositions. In other embodiments, the present invention provides methods of identifying plasmodium infection employing agents that bind to evp1 or an antibody generated thereto..
10/03/13
20130261133
Therapeutic compounds for protozoal and microbial infections and cancer
The compounds of the invention exhibit antiprotozoal, antimicrobial, and anticancer properties that are useful for the treatment or prevention of infections or cancer in a patient (e.g., a human). For example, the compounds and methods described herein can be used for the treatment or prevention of protozoal infections such as leishmaniasis, malaria, and trypanosoma infections, bacterial infections such as s.
10/03/13
20130259945
Anti-malaria compositions and methods
Multilayer films comprise polypeptide epitopes from plasmodium falciparum, specifically a circumsporozoite t1, b or t* epitope. The multilayer films are capable of eliciting an immune response in a host upon administration to the host.
10/03/13
20130259890
Plasmodium falciparum circumsporozoite vaccine gene optimization for soluble protein expression
The present invention provides novel nucleotide sequence and other constructs used for expression of novel recombinant p. Falciparum circumsporozoite proteins in bacterial cells such as e.
09/19/13
20130244962
Cysteine protease inhibitors for the treatment of parasitic diseases
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, african trypanosomiasis, chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, stronglyoidiasis, trichostrongyliasis, trichomoniasis or cestodiasis..
09/19/13
20130243886
Novel use
The present invention relates to the use of one or more compounds selected from the following classes of biologically active agents: an a-adrenergic antagonist, an anthelmintic agent, an antifungal agent, an antimalarial agent, an antineoplastic agent, an antipsychotic agent, an antioxidant, a vasodilator and/or a vitamin, or a pharmaceutically acceptable derivative thereof, for use in the treatment of a microbial infection and in particular for killing multiplying, non-multiplying and/or clinically latent microorganisms associated with such an infection.. .
09/05/13
20130231296
New drug combinations for the treatment of malaria
The present invention relates to pharmaceutical preparations/compositions comprising 3-n-formyl hydroxy amino propyl phosphonic acid derivatives or 3-n-acetyl hydroxy amino propyl phosphonic acid derivatives as active ingredients in combination with piperaquine.. .
09/05/13
20130230857
Hybrid selection using genome-wide baits for selective genome enrichment in mixed samples
The present invention provides methods for sequencing and genotyping of dna useful for analysis of samples in which the target dna represents a small portion (e.g., 10-1000-fold less) that a contaminating dna source. Accordingly, the methods described herein are useful for sequencing or genotyping pathogen dna, such as malaria dna, in clinical samples taken from infected subjects..
08/29/13
20130224848
Device and method for detection and quantification of immunological proteins, pathogenic and microbial agents and cells
The present invention provides a method and device for detecting and quantifying the concentration of magnetic-responsive micro-beads dispersed in a liquid sample. Also provided is a method and microfluidic immunoassay pscreen™ device for detecting and quantifying the concentration of an analyte in a sample medium by using antigen-specific antibody-coated magnetic-responsive micro-beads.
08/22/13
20130217913
Antimalarial drug comprising alaremycin or derivative thereof as active ingredient
Provided is a preventive and/or therapeutic agent for malaria, comprising, as an active ingredient, 5-acetamido-4-oxo-5-hexenoic acid (alaremycin) or a derivative thereof. A preventive and/or therapeutic agent for malaria is used which comprises, as an active ingredient, alaremycin or a derivative thereof represented by formula (i) (wherein r1 represents a hydroxy group, an amino group, or a substituted or unsubstituted straight chain or branched alkoxy group or alkylamino group having 1 to 8 carbons; r2 represents hydrogen, a substituted or unsubstituted straight chain or branched alkyl group having 1 to 8 carbons, or a substituted or unsubstituted aromatic group having 4 to 10 carbons; and r3 represents hydrogen or a methyl group)..
08/22/13
20130216580
Heterologous prime boost vaccination regimen against malaria
Described are methods for inducing an immune response in a subject against an antigen from a malaria-causing parasite, preferably p. Falciparum, the method comprising: (i) administering to a subject a priming composition comprising adjuvanted proteinaceous antigen-comprising circumsporozoite (cs) protein or an immunogenic part thereof from a malaria-causing parasite; (ii) administering to the subject a first boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding cs protein or immunogenic part thereof from a malaria-causing parasite; and (iii) administering to the subject a second boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding cs protein or an immunogenic part thereof from a malaria-causing parasite, wherein either the first boosting composition comprises a recombinant adenovirus vector of serotype 35 (ad35) and the second boosting composition comprises a recombinant adenovirus of ad26, or wherein the first boosting composition comprises a recombinant adenovirus vector of ad26 and the second boosting composition comprises a recombinant adenovirus of ad35..
08/22/13
20130216579
Methods and compostitions for gene editing of a pathogen
Disclosed herein are methods and compositions for genome editing of the malarial parasite plasmodium, and for the use of the edited plasmodium in the development of vaccines and therapeutics.. .
08/22/13
20130216570
Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia
Disclosed are immunogenic conjugates which elicit an immune response to plasmodium proteins. In particular examples, the plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (csp), or immunogenic portions of csp.
08/15/13
20130210023
Nucleic acid aptamers against plasmodium lactate dehydrogenase and histidine-rich protein ii and uses thereof for malaria diagnosis
The present invention provides nucleic acid aptamers that bind to plasmodium proteins lactate dehydrogenase and histidine-rich protein ii, and uses thereof for the diagnosis of malaria. Aptamers against histidine-rich protein ii may be used to detect the presence of plasmodium species in general, whereas aptamers against lactate dehydrogenase can be used to specifically detect plasmodium falciparum..
08/08/13
20130202646
Compositions and methods for modulating autophagy
In alternative embodiments, the invention provides cell-permeable recombinant or synthetic proteins to modulate autophagy, including a tat-atg5k130r (inhibitor of autophagy) and a tat-beclin 1 (stimulant or activator of autophagy), and nucleic acids expressing them and methods for making and using them, e.g., to treat conditions and disorders responsive to autophagy modulation (e.g., where autophagy is dysregulated), including neurodegeneration, cystic fibrosis, cancer, heart failure, diabetes, obesity, sarcopenia, aging, ischemia/reperfusion, inflammatory disorders including crohns, ulcerative colitis, biliary cirrhosis, lysosomal storage diseases, infectious diseases associated with intracellular pathogens including viruses, bacteria, and parasites such as trypanosomes and malaria.. .
07/18/13
20130183377
Synthetic immunogen useful for generating long lasting immunity and protection against pathogens
The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, aids, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent hla restriction in humans and livestock.
07/18/13
20130183332
Treatment and prevention of malaria
There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising a reticulocyte-binding protein homologue 5 (pfrh5) antigen having at least 90% identity with seq id no: 1, or a fragment thereof; or which comprise a viral vector that expresses pfrh5 antigen having at least 90% identity with seq id no: 2, or a fragment thereof..
07/04/13
20130171195
Lentiviral vector based immunological compounds against malaria
The invention relates to lentiviral vector particles pseudotyped with a determined heterologous viral envelope protein or viral envelope proteins originating from a rna virus and which comprise in its genome at least one recombinant polynucleotide encoding at least one polypeptide(s) carrying epitope(s) of an antigen of a plasmodium parasite capable of infecting a mammalian host. The lentiviral vector particles are used in order to elicit an immunological response against malaria parasites..
06/27/13
20130164328
Methods for enhancing immune response
This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (pbt) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction.
06/20/13
20130158267
Method of synthesizing the complex [zn(nns)2] active against the malaria parasite plasmodium
Metal complex of zinc(ii) containing a dithio-based ligand have been synthesized and characterized by elemental analysis, mass spectrometry, proton nmr and ft-ir spectrometry. A single crystal x-ray structure of the cadmium complex has been analyzed.
06/20/13
20130158014
Method for treating diseases associated with alterations in cellular integrity using rho kinase inhibitor compounds
This invention is directed to methods of preventing or treating diseases or conditions associated with alterations in cellular integrity including alterations in endothelial permeability, excessive cell proliferation or tissue remodeling. Particularly, this invention is directed to methods of treating diabetic nephropathy, malaria, or cancer.


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Malaria topics: Plasmodium, Immunogenic, Immune Response, Recombinant, Parasitic Diseases, Parasitic Disease, Leishmaniasis, Leishmania, Autoimmune Disease, Autoimmune, Neurological Disease, Inflammation, Neurological, Immune Disease, Traumatic Brain Injury

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