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Malar patents



      
           
This page is updated frequently with new Malar-related patent applications. Subscribe to the Malar RSS feed to automatically get the update: related Malar RSS feeds. RSS updates for this page: Malar RSS RSS


Date/App# patent app List of recent Malar-related patents
07/17/14
20140200226
 Anti-malarial compounds from marine natural products patent thumbnailAnti-malarial compounds from marine natural products
Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.. .
07/10/14
20140194640
 Quaternary n-(halomethyl) ammonium salts as therapeutic agents patent thumbnailQuaternary n-(halomethyl) ammonium salts as therapeutic agents
The use of quaternary halogenated ammonium salts for treating leishmaniasis infections and other parasitic diseases is described. Although there have been previous reports in which quaternary ammonium salts are used as antimalarial, antifungal, and antileishmanial compounds, the use of such salts containing a halogenated n-methyl substituent as a therapeutic agent against leishmaniasis had not been reported.
07/10/14
20140193493
 Solid dosage forms of oleyl phosphocholine patent thumbnailSolid dosage forms of oleyl phosphocholine
The present invention relates to solid dosage forms of oleyl phosphocholine (c18:1-pc), or olpc, for oral administration. Further, the present invention relates to methods for the preparation of the present solid dosage forms and the use thereof as a medicament and especially a medicament for treatment of parasitic diseases, such as leishmaniasis, chagas and malaria, and cancer both in humans and animals.
07/03/14
20140186402
 Blood stage malaria vaccine patent thumbnailBlood stage malaria vaccine
An immunogenic composition for use as a blood-stage malaria vaccine, a method of producing the immunogenic composition and a method of treatment of malaria are provided. The immunogenic composition includes isolated or purified merozoites, or red blood cells infected with merozoites, treated with centanamycin or tafuramycin a.
06/26/14
20140179772
 Anti-malarial pharmaceutical composition patent thumbnailAnti-malarial pharmaceutical composition
The invention provides pharmaceutical compositions for the treatment and prophylaxis of malaria, comprising artemether and a medium chain triglyceride formulated for transmucosal sublingual, buccal or nasal delivery, especially by a spray. Also provided are delivery devices containing the compositions..
06/19/14
20140171438
 Hybrid compounds and methods of making and using the same patent thumbnailHybrid compounds and methods of making and using the same
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a mycobacterium infection; killing or inhibiting the growth of a plasmodium species; inhibiting the growth of a mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.. .
06/05/14
20140155367
 Compounds and compositions for the treatment of parasitic diseases patent thumbnailCompounds and compositions for the treatment of parasitic diseases
Or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a plasmodium parasite, such as malaria..
06/05/14
20140154289
 Attenuated plasmodium with deactivated hmgb2 gene, as vaccine patent thumbnailAttenuated plasmodium with deactivated hmgb2 gene, as vaccine
The present invention relates to novel compositions and methods for immunizing a host against malaria using a plasmodium parasite genetically attenuated via the inactivation of the function of the hmgb2 gene.. .
05/29/14
20140147414
 Compositions and methods for treatment of intracellular damage patent thumbnailCompositions and methods for treatment of intracellular damage
Pre-implantation factor (pif) may be used to treat intracellular damage. Aspects of the invention are directed to a method of treating intracellular damage comprising administering pif to a subject in need thereof.
05/15/14
20140135360
 Aryl derivatives and uses thereof patent thumbnailAryl derivatives and uses thereof
The present invention relates to antimalarial compounds and their use against protozoa of the genus plasmodium, including drug-resistant plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds..
05/15/14
20140135320
Heteroaryl derivatives and uses thereof
The present invention relates to antimalarial compounds and their use against protozoa of the genus plasmodium, including drug-resistant plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds..
05/15/14
20140134657
Screening methods for identifying plasmodium proteases inhibitors
The invention relates to the field of parasitology. Methods and peptidic substrate for screening and identifying inhibitors of plasmodium are described.
05/08/14
20140128423
Acridone compounds
A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents.
05/08/14
20140128408
Hdac inhibitors and therapeutic methods using the same
Histone deacetylases inhibitors (hdacis) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of hdac provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed..
05/01/14
20140121238
Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.. .
05/01/14
20140120633
Devices and methods for detection and quantification of immunological proteins, pathogenic and microbial agents and cells
The present invention provides a method and microfluidic immunoassay pscreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, rna, rna fragments, functionalized magnetic micro-beads specific to cd4+, cd8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays..
05/01/14
20140120138
Pharmaceutical compositions comprising attenuated plasmodium sporozoites and glycolipid adjuvants
Disclosed herein are pharmaceutical compositions comprising plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range plasmodium and analogues of α-galactosylceramide (α-galcer), a ligand for natural killer t (nkt) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria.
04/24/14
20140112930
Methods for treating or preventing malaria by administering an antibody that specifically binds angiopoietin-2 (ang-2)
The present invention provides methods for treating or preventing malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody that specifically binds human angiopoietin-2 (ang-2).. .
04/10/14
20140100240
Natural product derivatives with antiprotozoal activity
The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.. .
04/10/14
20140100198
Enzyme inhibiting compounds and methods
The invention provides compounds, compositions, and methods for studying the rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria.
04/10/14
20140100178
Composition and methods for site-specific drug delivery to treat malaria and other liver diseases
A system for selectively delivering drugs to target tissues is provided. The system includes a drug-linker-saccharide-drug conjugate (d-l-a-d1).
04/03/14
20140093530
Malaria vaccines
The present invention relates to a synthetic antigenic sequence which represents a combination of epitope-containing sequences from the highly polymorphic block 2 repeat region of k1-type plasmodium falciparum merozite surface antigen (msp1) and fusion proteins containing that sequence in combination with additional epitope-containing sequences capable of inducing antibody and cellular immune responses to p. Falciparum antigens.
03/27/14
20140088082
Inhibitors of the plasmodial surface anion channel as antimalarials
Or a pharmaceutically acceptable salt thereof, wherein r1 to r7 are as described herein.. .
03/27/14
20140087399
Assay method for peptide specific t-cells
A method of assaying for peptide-specific t-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon-y produced by t-cells that have been pre-sensitised to the peptide. The assay method is quick and cheap and is expected to be useful for the study of various disease states including hepatitis b, hepatitis c, tuberculosis, malaria, hiv and influenza..
03/20/14
20140079736
Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula (i): q-y—r1—r2 (i), wherein q, y, r1, and r2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided.
03/13/14
20140072663
Compositions and methods for treating multi-drug resistant malaria
A method is provided for treating an individual for a malarial infection, in particular drug-resistant species of plasmodium, including administering to the individual in need of such treatment a composition comprising an extract containing an effective amount of one or more anti-malarial di- or tri-terpene compounds. Potent and effective extracts containing the anti-malarial compounds can be derived from luo han fruit and stevia leaves, including combinations of the same, for the purpose of treating and preventing malaria in an inexpensive manner from readily available commodities.
02/20/14
20140050696
Novel bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention.
02/06/14
20140039240
Applying torque to paramagnetic structures in bodies using dual magnetic fields
Techniques for applying torque to microscopic paramagnetic structures in a body includes exposing a body simultaneously to a first magnetic field oscillating at a first frequency in a first direction and a different second magnetic field oscillating at a second frequency in a second direction. The body includes a plurality of microscopic paramagnetic structures for which magnetic susceptibility to the first magnetic field is different from magnetic susceptibility to the second magnetic field.
02/06/14
20140037577
Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing diindolylmethane-related indoles. Additive and synergistic interaction of diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections.
01/09/14
20140011830
Artemisinin-based combination therapy for treating parasitic mediated disease
The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved artemisinin combination therapy, known as tri-act. The improved act therapy includes administering a combination of three drugs.
01/09/14
20140010816
Treatment and prevention of malaria
The present invention relates to polypeptides from plasmodium and polynucleotides encoding the polypeptides. The invention further relates to compositions comprising the polypeptides and their use in the treatment and prevention of malaria..
12/05/13
20130324727
Anti-folate antimalarials with dual-binding modes and their preparation
The present invention is anti-folate antimalarials with dual-binding modes of the general formula (i) [refer to structure in the abstract] wherein r1 and r2 which may be the same or different are independently selected from methyl or ethyl or alkyl-phenyl, r3 is independently hydrogen, halide, lower alkyl substituted with ester, carboxylic, amide, and ether. Linker is x(ch2)ny wherein x and y which may be the same or different are independently selected from oxygen, carbon, nitrogen, substituted phenyl where n is an integer from 1 to 2-6, or pharmaceutically acceptable salts therefore.


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Malar topics: Plasmodium, Immunogenic, Immune Response, Recombinant, Parasitic Diseases, Parasitic Disease, Leishmaniasis, Leishmania, Autoimmune Disease, Autoimmune, Neurological Disease, Inflammation, Neurological, Immune Disease, Traumatic Brain Injury

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This listing is a sample listing of patent applications related to Malar for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Malar with additional patents listed. Browse our RSS directory or Search for other possible listings.
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