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Major Histocompatibility Complex

Major Histocompatibility Complex-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Tumor lysate loaded particles
Orbis Health Solutions Llc
November 09, 2017 - N°20170319620

Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the major histocompatibility complex class i pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
Curcuphenol compounds for increasing mhc-i expression
Biommune Technologies Inc.
November 09, 2017 - N°20170319508

Provided are methods of using curcuphenol compounds to increase expression of major histocompatibility complex class i (mhc-i) antigen in cells, particularly on the surface of diseased cells such as cancer cells, and thereby increase the immunogenicity of the cells. Also provided are pharmaceutical compositions that comprise curcuphenol compounds and methods of use thereof, for instance, to treat various cancers, alone ...
Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
Biommune Technologies Inc.
November 02, 2017 - N°20170312350

The present description relates to t-cell receptors (tcrs) binding to tumor-associated antigens (taas) for targeting cancer cells, t-cells expressing same, methods for producing same, and methods for treating cancers using same. In particular, the present description relates to tcrs and their variants that bind to hla class i or ii molecules with a peptide, such as igf2bp3-001 have ...
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Peptides and combination of peptides for use in immunotherapy against non-small cell lung cancer and ...
Immatics Biotechnologies Gmbh
October 19, 2017 - N°20170296641

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate antitumor ...
Novel peptides and combination of peptides for use in immunotherapy against nhl and other cancers
Immatics Biotechnologies Gmbh
October 19, 2017 - N°20170296640

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Peptides and combination of peptides as targets or active ingredients for use in immunotherapy against ...
Immatics Biotechnologies Gmbh
October 12, 2017 - N°20170290897

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
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Peptide sequences and compositions
Peptcell, Ltd.
October 05, 2017 - N°20170281750

The present specification discloses an immunogenic composition comprising polypeptide, wherein each of the polypeptides has no more than 100 amino acids, which polypeptides comprises one or more sequences having at least 60% homology with any of seq id 1-4, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of ...
Genetically modified major histocompatibility complex animals
Regeneron Pharmaceuticals, Inc.
September 28, 2017 - N°20170273286

The invention provides genetically modified non-human animals that express a humanized mhc ii protein (humanized mhc ii α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized mhc ii protein. Also provided are constructs for making, and methods of making, the genetically modified non-human animals. Methods of using the genetically modified non-human animals to ...
Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
Immatics Biotechnologies Gmbh
September 21, 2017 - N°20170267738

Disclosed are t-cell receptors (tcrs) binding to tumor-associated antigens (taas) for targeting cancer cells, t-cells expressing same, methods for producing same, and methods for treating cancers using same. Disclosed are tcrs and their variants that bind to hla class i or ii molecules with a peptide, such as mag-003 have the amino acid sequence of kvlehvvrv (seq id no:1). The ...
Peptides and combination of peptides for use in immunotherapy against cancers
Immatics Biotechnologies Gmbh
September 21, 2017 - N°20170266271

The present description relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present description relates to the immunotherapy of cancer. The present description further relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Uterine cancer treatments
Immatics Biotechnologies Gmbh
September 14, 2017 - N°20170260249

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Method for the detection of antigen presentation
Deutsches Krebsforschungszentrum Stiftung Des öffentlichen Rechts
September 07, 2017 - N°20170254803

The present invention pertains to a method for detecting antigen presentation via antigen presenting molecules such as major histocompatibility complex (mhc) class i or ii. The invention deploys a first binding agent specific for the antigen epitope and a second binding agent specific for the antigen presenting molecule. The binding agents of the invention are coupled to proximity probes which ...
Peptides, combination of peptides, and cell based medicaments for use in immunotherapy against urinary bladder ...
Immatics Biotechnologies Gmbh
September 07, 2017 - N°20170253633

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
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Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189513

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189512

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189511

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189510

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189509

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189508

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189507

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189506

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
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