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Major Histocompatibility Complex

Major Histocompatibility Complex-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer ...
Immatics Biotechnologies Gmbh
November 30, 2017 - N°20170342125

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Molecular constructs and uses thereof
The University Of Notre Dame Du Lac
November 23, 2017 - N°20170333524

Molecular constructs and dual recognition constructs having a sequence encoding a tcr affinity weakening motif, and dna and rna sequences corresponding thereto, are presented. Modified t-cells and other cells transformed with the molecular contracts express a modified tcr that imparts a reduction, in non-specific binding, an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, ...
Tumor lysate loaded particles
Orbis Health Solutions Llc
November 09, 2017 - N°20170319620

Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the major histocompatibility complex class i pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
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Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
November 02, 2017 - N°20170312350

The present description relates to t-cell receptors (tcrs) binding to tumor-associated antigens (taas) for targeting cancer cells, t-cells expressing same, methods for producing same, and methods for treating cancers using same. In particular, the present description relates to tcrs and their variants that bind to hla class i or ii molecules with a peptide, such as igf2bp3-001 have ...
Immunotherapy against melanoma and other cancers
Immatics Biotechnologies Gmbh
October 26, 2017 - N°20170305991

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Peptides and combination of peptides for use in immunotherapy against non-small cell lung cancer and ...
October 19, 2017 - N°20170296641

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate antitumor ...
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Peptides and combination of peptides as targets or active ingredients for use in immunotherapy against ...
Immatics Biotechnologies Gmbh
October 12, 2017 - N°20170290897

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Modified cells evoking reduced immunogenic responses
Zhejiang University
October 05, 2017 - N°20170283769

The present disclosure describes composition, methods, and systems associated with a genetically modified stem cell. The modified stem cell includes a reduced amount of major histocompatibility complex ii (mhc ii) as compared to a corresponding wild-type cell. Further, the modified cell has decreased immunogenicity as compared to the corresponding wild-type cell.
Peptide sequences and compositions
Peptcell, Ltd.
October 05, 2017 - N°20170281750

The present specification discloses an immunogenic composition comprising polypeptide, wherein each of the polypeptides has no more than 100 amino acids, which polypeptides comprises one or more sequences having at least 60% homology with any of seq id 1-4, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of ...
Genetically modified major histocompatibility complex animals
Regeneron Pharmaceuticals, Inc.
September 28, 2017 - N°20170273286

The invention provides genetically modified non-human animals that express a humanized mhc ii protein (humanized mhc ii α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized mhc ii protein. Also provided are constructs for making, and methods of making, the genetically modified non-human animals. Methods of using the genetically modified non-human animals to ...
Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
Immatics Biotechnologies Gmbh
September 21, 2017 - N°20170267738

Disclosed are t-cell receptors (tcrs) binding to tumor-associated antigens (taas) for targeting cancer cells, t-cells expressing same, methods for producing same, and methods for treating cancers using same. Disclosed are tcrs and their variants that bind to hla class i or ii molecules with a peptide, such as mag-003 have the amino acid sequence of kvlehvvrv (seq id no:1). The ...
Peptides and combination of peptides for use in immunotherapy against cancers
Immatics Biotechnologies Gmbh
September 21, 2017 - N°20170266271

The present description relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present description relates to the immunotherapy of cancer. The present description further relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Uterine cancer treatments
Immatics Biotechnologies Gmbh
September 14, 2017 - N°20170260249

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
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Peptides, combination of peptides, and cell based medicaments for use in immunotherapy against urinary bladder ...
Immatics Biotechnologies Gmbh
September 07, 2017 - N°20170253633

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Method for identifying epitope on protein
Chugai Seiyaku Kabushiki Kaisha
August 03, 2017 - N°20170219607

In one aspect, the present invention provides, for example, an improved method for identifying an epitope on a protein, comprising the following steps: (a) contacting a major histocompatibility complex (mhc molecule)-expressing cell differentiated from a stem cell or a progenitor cell derived therefrom with a target protein; (b) isolating a complex of a peptide contained in the target protein ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189513

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189512

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189511

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189510

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189509

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Novel peptides and combination of peptides for use in immunotherapy against various cancers
Immatics Biotechnologies Gmbh
July 06, 2017 - N°20170189508

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
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