|| List of recent Macro-related patents
| Application aware elephant flow management|
A network device manages elephant flows. The network device filters received network data according to an application-specific criteria and identifies the elephant flow from the filtered network data.
| Object oriented system for managing complex financial instruments|
Object oriented design strategies and patterns are applied to financial data processing systems for processing and modeling of financial products (also referred to as financial instruments) with an emphasis being on derivative products. The system employs valuation independent, well-defined financial components (also referred to as financial events) that can be combined to build new financial structures.
| Process for preparing an intermediate of the macrocyclic protease inhibitor tmc 435|
The present invention relates to an improved process for preparing (2r,3ar,10z,11as,2ar,14ar)-cyclopenta[c]cyc-lopropa[g][1,6]diazacyclotetradecine-12a(1h)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2[[7-methoxy-8-methyl-2-[4-10 (1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, ethyl ester. This compound is an intermediate in the overall synthesis route of the macrocyclic compound tmc 435.
| Biocompatible phase invertible proteinaceous compositions and methods for making and using the same|
Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent.
| Macromonomer mixture, terminal-reactive polymer mixture, intermediate for macromonomer and silicone hydrogel|
To obtain a hydrophilic macromonomer mixture which is a highly polymerized hydrophilic macromonomer, has few components not bonded to the polymer chain after polymerization, and is less likely to leaching. Provided is a macromonomer mixture containing macromonomer a being a macromonomer having a group obtained by further introducing a polymerizable group into a reactive group derived from a polymerization initiator at an end thereof; and macromonomer b being a macromonomer having a group obtained by further introducing a polymerizable group into a reactive group derived from a chain transfer agent at an end thereof..
| Cancer cell targeting using nanoparticles|
The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties.
| Compositions and methods for introduction of macromolecules into cells|
Disclosed are novel compositions and methods for introduction of macromolecules and nanoparticles into living cells. The invention includes a polypeptide sequence which when fused to a macromolecule or nanoparticle enhances its introduction into the cell..
| Self calibration of downlink transmit power|
Transmit power (e.g., maximum transmit power) may be defined based on the maximum received signal strength allowed by a receiver and a total received signal strength from transmitting nodes at the receiver. Transmit power may be defined for an access node (e.g., a femto node) such that a corresponding outage created in a cell (e.g., a macro cell) is limited while still providing an acceptable level of coverage for access terminals associated with the access node.
| Femtocell measurements for macro beam steering|
Attachment data collected by a set of femto access points (faps) is utilized to localize, predict, and/or weight potential wireless communication traffic within and between areas. Moreover, the attachment data can be indicative of user equipment (ue) density/traffic within coverage areas of respective femtocells.
| Method for diagnosis, prognosis or treatment of acute coronary syndrome (acs) comprising measurement of plasma concentration of macrophage migration inhibitory factor (mif)|
A method for diagnosing acute coronary syndrome (acs) in a subject, the method comprising measuring plasma macrophage migration inhibitory factor (mif) concentration in a sample from the subject, and diagnosing acs when the subject plasma mif concentration is greater than a reference plasma mif concentration, wherein the sample is taken less than 4 hours after symptom onset. The invention also relates to a method for prognosing acs in a subject, the method comprising measuring plasma mif concentration in a sample from the subject, diagnosing acs when the subject plasma mif concentration is greater than a reference plasma mif concentration, and prognosing the magnitude of acs from the subject plasma mif concentration.
| Test pad structure for reuse of interconnect level masks|
A test pad structure in a back-end-of-line metal interconnect structure is formed by repeated use of the same mask set, which includes a first line level mask, a first via level mask, a second line level mask, and a second via level mask. The test pad structure includes a two-dimensional array of test pads such that a first row is connected to a device macro structure in the same level, and test pads in another row are electrically connected to another device macro structure of the same design at an underlying level.
| Novel nano gold and process for preparation|
This invention relates to bio synthesis of novel nano gold through environment friendly process with the aid of plant materials classified under the taxonomical genus dalbergia, citrus, ferula and dolichos or macrotyloma. The present inventive product novel nano gold finds utility in, the treatment of humans and animals, nutraceutical, cosmeceutical and herbal composition, the field of technology including but not limited to nano technology, green technology and bio technology.
| Targeted lipid-drug formulations for delivery of drugs to myeloid and lymphoid immune cells|
A method of preferentially delivering an active agent to an immune cell, such as a myeloid progenitor cell, a dendritic cell, a monocyte, a macrophage or a t-lymphocyte, or other cell type restricted to a functional organ system or an anatomic entity, of a mammalian subject by administering a lipid-drug complex to the subject. The lipid-drug complex is comprised of an active agent, such as a drug, and an outer surface with a targeting ligand that binds a marker on the surface of the immune cell or other cell type that is infected with or susceptible to infection with an infectious agent.
| Compositions and methods for treatment of bacterial and mycobacterial infections|
A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of gram negative, gram positive and acid fast bacilli in general and tuberculosis (tb), mycobacterium avium complex (mac), and anthrax in particular.
| System and method for detecting motion in compressed video|
A method and apparatus wherein the method includes the steps of parsing a stream of compressed video, obtaining macroblock size information from the parsed stream, computing factors derived from the macroblock size, wherein the factors include a normalized bit size, a bit size ratio and a neighbor score, computing corresponding adaptive threshold values derived from the relative frame characteristics of the compressed video, comparing the factors derived from the macroblock size information with the corresponding adaptive threshold values and detecting motion based upon combinations of the comparisons when the factors exceed the threshold value.. .
| Mobile paytv drm architecture|
A secure element operating in conjunction with a secure partition of a system-on-a-chip (soc) having set top box (stb) functionality allows for digital rights management (drm) key handling in a mobile platform. The secure element can include a secure processing system (sps) to be implemented as a hard macro, thereby isolating the sps from a peripheral processing system (pps).
| Soft cell inter-layer interference handling|
In a heterogeneous cell deployment a mobile terminal may need to receive control data transmissions from a macro node at the same time as a pico node is transmitting user data for the mobile terminal, using the same frequency or set of frequencies. This can result in a problematic interference situation.
| Application aware elephant flow identification|
A network device identifies elephant flows. The network device filters received network data according to an application-specific criteria and identifies the elephant flow from the filtered network data.
| Laboratory spatula|
Laboratory spatula having stalk regions with a hollow first end and a hollow second end and at manipulating regions may be used for collecting, transporting or storing a material. A manipulating region may be configured as a shovel region, a scoop region, a whisk region, a punch region, a sieve region, a loop region, a cutting edge, a spreading region, a grinding region, a hook region, a scraper region, a tweezer region, a grasper region, or a pick region.
| Hosiery with foot cushions|
A hosiery product, such as a sock, footie, trouser sock or pantyhose, includes an inner layer of hosiery material, such as nylon or spandex covering the bottom and top surfaces of the wearer's foot, an outer layer of similar hosiery material, and at least one cushion section disposed between the inner and outer layers. The cushion section includes a cushioning material that conforms to the contours of the wearer's foot, such as macro-gel activated support discs or memory foam.
|System and method for dataplane extensibility in a flow-based switching device|
A network switching device includes a macroflow sub-plane that performs packet-based routing, a microflow routing module that performs flow-based routing, and a software defined network (sdn) agent. The microflow routing module includes a packet processing module and a virtual port, and is operable to determine that the packet processing module is to be utilized to process a flow, direct the flow to the packet processing module via the virtual port in response to determine that the packet processing module is to be utilized to process the flow, process the flow using the packet processing module, and direct the flow to a destination associated with the flow.
|Method for reducing tumors and transforming cancer cells|
This invention is related to a phenol-quinone therapy that shrinks tumors and transforms cancer cells. The therapy include four phases.
|Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv|
Disclosed is a process for the preparation of a cinchonidine salt of formula (iv) via an aqueous solution of a racemic 4-hydroxy-1,2-cyclopentanedicarboxylic acid, which is subjected to cyclization without removing water, by the addition of a water-miscible organic solvent to the aqueous solution and, again without removing water, adding cinchonidine to the aqueous-organic solvent solution so as to obtain the cinchonidine salt of the lactone acid. The cinchonidine salt is allowd to crystallize so as to obtain the enantiomerically purified crystalline lactone acid cinchonidine salt (iv).
|Antibiotic composition and its uses|
The present invention relates to a composition comprising: an antibiotic selected from the group consisting of an aminoglycoside antibiotic, a beta-lactam antibiotic, an ansamycin antibiotic, a macrolide antibiotic, a sulfonamide antibiotic, a quinolone antibiotic, an oxazolidinone antibiotic, a glycopeptide antibiotic, and a mixture thereof; and a fatty acid represented by formula (i), a stereoisomer, a salt or an ester thereof, wherein r1 is a substituted or unsubstituted aliphatic group.. .
|Composition and method for treating an autoimmune disease|
A combination of antibiotics including rifabutin, clarithromycin and clofazimine for the treatment of an autoimmune disease such as multiple sclerosis and related diseases. In a further aspect, there is provided a composition comprising a combination of two or more antibiotic agents for the treatment of an autoimmune disease, said two or more antibiotic agents selected from rifabutin, clofazimine, and at least one macrolide..
|Integrated modular unit including an analyte concentrator-microreactor device connected to a cartridge-cassette|
The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers.
|Method for making a porous polymeric material|
Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second liquid is added to a polymer solution, the second liquid causing the solution to increase in viscosity.
|Pd-1 antagonists and methods for treating infectious disease|
Methods and compositions for treating an infection or disease that results from (1) failure to elicit rapid t cell mediated responses, (2) induction of t cell exhaustion, t cell anergy or both, or (3) failure to activate monocytes, macrophages, dendritic cells and/or other apcs, for example, as required to kill intracellular pathogens. The method and compositions solve the problem of undesired t cell inhibition by binding to and blocking pd-1 to prevent or reduce inhibitory signal transduction, or by binding to ligands of pd-1 such as pd-l1, thereby preventing (in whole or in part) the ligand from binding to pd-1 to deliver an inhibitory signal.
|Synchronization signals in a wireless communication system|
Cell-specific or transmission point (tp)-specific information is indicated to a ue based on the subframe in which a cell/tp transmits its primary and secondary synchronization sequences (pss and sss). The principal scenario of interest is a dense deployment of picocells/tps which are under the control of an overlaid macrocell's enodeb.
|Systems and methods for small cell uplink interference mitigation|
Systems and methods for facilitating the mitigation of interference in the uplink of a small cell caused by macrocell user equipment in the case where the macrocell cannot identify the interfering macrocell user equipment because the user equipment cannot detect and report the small cell's downlink due to the small cell's uplink/downlink coverage imbalance. In an embodiment, the smell cell provides the macrocell with a notification of the interference, the configuration information about its physical random access channel (prach), and a plurality of unique preambles and transmission times for non-contention-based transmissions on the small cells prach.
|Rescheduling of a resource component of low power nodes (lpns) in a coordination set|
A method for rescheduling a resource component of low power nodes (lpns) in a local coordination set is disclosed. The method can include a local macro node receiving from a neighboring macro node a resource map of blanked resource components and scheduled resource components for physical resources of the neighboring macro node.
|Virtual macro cells|
Systems and methods that provide a virtual macro cell in a heterogeneous cellular communications network are disclosed. In general, micro cells served by multiple micro base stations are aggregated to provide a virtual macro cell.
|Design for small cell demodulation reference signal and initial synchronization|
Described herein is a system with a first network element and a second network element. The first network element contains a processor configured to synchronize with the second network element; and maintain synchronization with the second network element.
|Pressure sensitive adhesive laminate for high performance noise and vibration damping applications|
A pressure sensitive adhesive composition and laminate and having superior adhesive and damping properties is provided. The adhesive laminate includes an acrylic damping composition comprising a graft copolymer having an acrylic backbone and macromonomer side chains..
|Macroperforator machine for plastic film|
Machine for producing macroperforated plastic film by means of a cold-stamping process, using entrainment (3) and stamping (4) rollers, with adjustment of pressure; said machine is provided with an automated system for recovering the excess material cut out for the recycling (8) thereof and the purpose of the machine is to produce a (single-layer or multi-layer) sheet of macroperforated film for use, essentially, in the packaging of palletized systems, thereby allowing optimum ventilation without creating a thermal barrier, resulting in a reduction in consumption of polymeric materials with no reduction in mechanical strength.. .
|A2m fragments and applications thereof|
The application relates to a polypeptide, the amino acid sequence of which is the sequence of a sub-fragment of the c-terminal thioester-cleaved fragment of human alpha-2-macroglobulin (a2m), wherein the molecular weight of said polypeptide is of 36 to 44 kda, and wherein the first n-terminal amino acid of said polypeptide is an amino acid, which, in the full length sequence of said human a2m, is at a position 1,098 or 1,085 or 1,084 or 1,083, and the last c-terminal amino acid of said polypeptide is an amino acid, which, in the full length sequence of said human a2m, is one of the last twenty c-terminal amino acids. This polypeptide is differently abundant depending on the stage of liver fibrosis.
|Determining dependencies during macro expansion|
In certain embodiments, a parser parses a formula to yield one or more functions, at least one function comprising a dependent value of a dependent object. One or more macro handlers configured to execute the functions are determined.
|Decorated macromolecular scaffolds|
The present invention relates to a method for preparing decorated macromolecular scaffolds. The method of the invention is useful for the generation of bioactive nanoparticles for use in clinical applications.
|Method for modifying surface properties with nanostructured chemicals|
A method of using metallized and nonmetallized nanostructured chemicals as surface and volume modification agents within polymers and on the surfaces of nano and macroscopic particulates and fillers. Because of their 0.5 nm-3.0 nm size, nanostructured chemicals can be utilized to greatly increase surface area, improve compatibility, and promote lubricity between surfaces at a length scale not previously attainable..
|Novel macrocycles as factor xia inhibitors|
The present invention provides compounds of formula (ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor xia inhibitors or dual inhibitors of fxia and plasma kallikrein.
|Use of macrolides in pest control|
In an embodiment the present invention is drawn to a a method of controlling wood pests and molluscs with a macrolide compound, wherein a pesticidally active amount of a pesticide comprising, as pesticidally active compound, at least one macrolide, in free form or agrochemically utilizable salt form, as active ingredient and at least one auxiliary is applied to the pests or their environment.. .
|Anti-parasitic composition comprising a macrocyclic lactone and levamisole and method of treatment of parasitic infestation|
This invention relates to a veterinary antiparasitic solubilised composition including a macrocyclic lactone or a pharmaceutically equivalent salt thereof, and levamisole or a pharmaceutically equivalent salt thereof, characterised in that the ph of the composition is in the range of 2.0 to 5.0 and wherein the composition includes at least one surfactant and at least one antioxidant.. .
|Low overhead mobility in local area wireless network|
In a heterogeneous network, enhanced handover and reestablishment procedures are proposed within a local area network. The enhanced procedures are more efficient, e.g., with less signaling and less data interruption than the legacy mobility mechanism.
|Agents and method for treating inflammation-related conditions and diseases|
Gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages. Gene-modified, inflammation-specific macrophages that comprise a 1-alpha-hydroxylase gene.
|Compositions and methods for wound healing, and for recruitment and activation of macrophages in injured tissues and in implanted biomaterials used for tissue engineering|
The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osetoarthritic diseases, or diabetes) and to healing of internal injuries. In particular, the present invention provides compositions and methods comprising molecules and nanoparticles with linked α-gal epitopes for induction of recruitment and activation of macrophages localized within or surrounding damaged and/or injured tissue.
|Dry powder formulations of organic macromolecules|
The present invention relates to methods for making a stabilized powder formulation for inhalation comprising a macromolecule in lyophilized form, a crystalline carrier material, and magnesium stearate.. .
|Image data encoding for access by raster and by macroblock|
Access encoding/decoding of image data has at least two preferred access modes, raster access and macroblock access. Arriving rasters containing pixels from an image sensor are converted to encoded macroblocks to support later random macroblock and raster access.
|Methods, systems, and computer program products for assessing a macroblock candidate for conversion to a skipped macroblock|
A sequence of encoded data associated with a block of video is assessed to determine if: quantized coefficients of transformed residual pixel data associated with the block are equal to zero, the block was encoded using a temporal compression process, a slice that includes the block is configured to be encoded using only one reference picture list or two reference picture lists, the block is unpartitioned or was encoded in direct mode, a reference picture used to encode the block is the reference picture associated with a lowest index value on the one reference picture list, and an actual motion vector associated with the block is equal to a predicted motion vector associated with the block.. .
|Apparatuses and methods for performing joint rate-distortion optimization of prediction mode|
Examples of apparatuses and methods for performing a joint rd optimization operation are described herein. A method may include successively encoding a macroblock using a plurality of coding modes.
|High rate packet data (hrpd) idle state handout from femto access point to macro access network|
Systems and methods for identifying an address of a femto node during handoff of an access terminal from a femto node to a macro node. In one embodiment, the femto node assigns a unique identifier to the access terminal.
|Method and an apparatus in a user equipment for controlling transmission power of the user equipment|
Disclosed are methods and apparatuses in user equipments (1400) and network nodes (1410, 420) for controlling transmission power of the user equipments when the user equipments are connected to a wireless network. The disclosed methods and apparatuses deals with independently controlling transmission power of srs signals and signals comprising traffic data from the user equipment (1400).
|Method and device for producing a structured surface on a steel embossing roller|
The method for structuring the surface of a steel embossing roller by means of short pulse laser, where the structuring is a macrostructuring with dimensions of over 20 μm and depths up to 150 μm and more, distinguishes itself by the following parameter combination: a) in single pulse operation a fluence in the range of 0.5 j/cm2 to 3.5 j/cm2 and in burst operation a mean burst fluence of 0.5 j/cm2 to 70 j/cm2 per pulse, b) wavelength of 532 nm to 1064 nm, c) repetition rate of 1 khz to 10 mhz, d) pulse to pulse spacing on the workpiece of 10% to 50% of the beam diameter for the femtosecond laser and of 10-25% and 40-50% of the beam width for the picosecond laser, e) laser pulse position near the workpiece surface, and f) deflection velocities of up to 100 m/s and more. ***such a method allow manufacturing a complete embossing roller with teeth and gaps for producing logos, the teeth having variable heights, shapes, and spacings, for embossing e.g.
|Dielectrophoretic tweezers as a platform for molecular force spectroscopy in a highly parallel format|
Provided herein are methods of performing force spectroscopy, the methods comprising the steps of providing dielectrophoretic tweezers having at least one set of macroscopic electrodes, at least one of the electrodes having a microfabricated dielectric structure comprising a microwell; depositing force probes on a surface; binding the force probes to molecules on the surface; and applying voltage across set of macroscopic electrodes to thereby manipulate the molecules. Also provided are novel apparatus for performing force spectroscopy, the apparatus comprising dielectrophoretic tweezers having at least one set of macroscopic electrodes, at least one of the electrodes having a microfabricated dielectric structure comprising a microwell..