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Bipartite inhibitors of bacterial rna polymerase

Date/App# patent app List of recent Linker-related patents
07/24/14
20140208457
 Nuclease fusion protein and uses thereof patent thumbnailnew patent Nuclease fusion protein and uses thereof
The present invention is concerned with nuclease fusion proteins and various uses thereof. Specifically, it relates to a polynucleotide encoding a polypeptide comprising (i) a first module comprising at least a first dna binding domain derived from a homing endonuclease, (ii) a linker, and (iii) a second module comprising at least a second dna binding domain and a cleavage domain derived from a restriction endonuclease, wherein said polypeptide functionally interacts only with dna comprising a dna recognition site for the first dna binding domain and a dna recognition site for the second dna binding domain, and wherein said cleavage domain cleaves dna within a specific dna cleavage site upon binding of the polypeptide.
07/24/14
20140206924
 Thermoplastic sheet, a radiation mask of thermoplastic sheet and method for providing said sheet and said mask patent thumbnailnew patent Thermoplastic sheet, a radiation mask of thermoplastic sheet and method for providing said sheet and said mask
The present invention relates to a thermoplastic composition suitable for manufacturing a thermoplastic sheet for producing a medical cast, such as a radiation mask. The composition has a polymeric component comprising a mixture of a styrene acrylonitrile copolymer and polycaprolactone, optionally together with a cross-linker and/or a filler, wherein the polymeric component comprises, 20 to 40 weight % of a styrene acrylonitrile copolymer and 80 to 60 weight % of a polycaprolactone, expressed in weight % of the polymeric component, wherein the thermoplastic composition has a glass transition temperature of 35° c.-80° c.
07/24/14
20140206860
 Nanoparticle chains and preparation thereof patent thumbnailnew patent Nanoparticle chains and preparation thereof
Fabrication and arrangement of nanoparticles into one-dimensional linear chains is achieved by successive chemical reactions, each reaction adding one or more nanoparticles by building onto exposed, unprotected linker functionalities. Optionally, protecting groups may be used to control and organize growth.
07/24/14
20140206847
 Mutant protein capable of binding specifically and quickly to troponin i derived from human myocardium patent thumbnailnew patent Mutant protein capable of binding specifically and quickly to troponin i derived from human myocardium
Provided is a mutant protein capable of binding specifically and quickly to troponin i derived from human myocardium. The mutant protein comprises a first mutant scfv antibody fragment 51 a second mutant scfv antibody fragment 52 and a linker 53.
07/24/14
20140206821
 Preparation of conjugated aromatic/heteroaromatic oligomer-containing dielectric polymers and their applications patent thumbnailnew patent Preparation of conjugated aromatic/heteroaromatic oligomer-containing dielectric polymers and their applications
A π-conjugated aromatic/heteroaromatic oligomer-containing vinyl monomer is generally provided, which can include a polymerizable group, a linker group, and a π-conjugated aromatic/heteroaromatic side chain. The π-conjugated aromatic/heteroaromatic side chain includes a first cyclopentadiene ring covalently attached to the linder group, a set of second cyclopentadiene rings covalently attached to the first cyclopentadiene ring, and a third cyclopentadiene ring positioned at a terminal end of the π-conjugated aromatic/heteroaromatic side chain such that the set of second cyclopentadiene rings is positioned between the first cyclopentadiene ring and the third cyclopentadiene ring.
07/24/14
20140206627
 Kisspeptide-pentasaccharide conjugates patent thumbnailnew patent Kisspeptide-pentasaccharide conjugates
The invention relates to kisspeptide-pentasaccharide conjugates having the general formula (i) wherein z1 is tyr or d-tyr; z3 is trp, hyp, phe or lys(r2); z5 is thr, aib or ala; z7 is gly or azagly; z8 is leu; or z7 and z8 together represent; z10 is phe or trp; n is 0 or 1; or r2, when present, represents a pentasaccharide derivative having the formula (ii) wherein r is methyl or so3x; x is a positively charged counterion; with the proviso that when r2 is present, r1 is h or (c1-6) alkylcarbonyl; r3 is h or (c1-3)alkyl; and l represents a pharmacologically inactive linker moiety having 10-50 atoms; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same as well as to the use of said kisspeptide-pentasaccharide conjugates in the treatment of female infertility.. .
07/24/14
20140206602
 Bipartite inhibitors of bacterial rna polymerase patent thumbnailnew patent Bipartite inhibitors of bacterial rna polymerase
The invention provides bipartite inhibitors of bacterial rna polymerase having the general structural formula (i): x-α-y (i) wherein x is an moiety that binds to the rifamycin binding site of a bacterial rna polymerase, y is a moiety that binds to the ge23077 binding site of a bacterial rna polymerase, and is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds.
07/24/14
20140206597
 Opioid prodrugs with heterocyclic linkers patent thumbnailnew patent Opioid prodrugs with heterocyclic linkers
The embodiments provide prodrug compounds of formulae i-xv. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug compound of formulae i-xv that provides controlled release of an opioid.
07/24/14
20140206557
 Novel reagents for directed biomarker signal amplification patent thumbnailnew patent Novel reagents for directed biomarker signal amplification
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors.
07/24/14
20140206553
 Massive parallel method for decoding dna and rna patent thumbnailnew patent Massive parallel method for decoding dna and rna
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of dna in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —oh group at the 3′-position of the deoxyribose..
07/24/14
20140206091
new patent Cross-linking compositions and related methods of isotope tagging of interacting proteins and analysis of protein interactions
An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (itip), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the ms/ms spectrum.
07/24/14
20140205995
new patent Molecular conjugate
A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays..
07/24/14
20140205539
new patent Dual acting prodrugs
The present invention relates to a prodrug which comprises at least two different pharmaceutically and/or diagnostically active compounds independently bound by cleavable linkers and a protein-binding moiety which is capable of binding to carrier a molecule.. .
07/24/14
20140204160
new patent Blanket materials for indirect printing method comprising structured organic films (sofs)
An intermediate image transfer member for indirect printing contains a layer containing a structured organic film (sof). The sof contains a plurality of segments including at least a first segment type and a plurality of linkers comprising at least a first linker type, arranged as a covalent organic framework (cof), where at least the first segment type optionally contains fluorine..
07/24/14
20140202398
new patent Dog harness
A dog harness is comprised of a torso strap encircling a dogs chest, connected to a chest strap passing around the chest of a dog, and a shoulder strap passing over the back of a dog. The chest strap is provided with a elongate linker.
07/17/14
20140200798
Driver assistance system and method for operating a driver assistance system
A driver assistance system for a vehicle including: a detection device for detecting the vehicle surroundings, a position determination device for determining a vehicle position relative to the vehicle surroundings, a database having an ontological data structure in which traffic rules are implemented, a linker for linking the detected vehicle surroundings and the vehicle position to the ontological data structure to form a linked data structure, and an evaluator for evaluating the linked data structure. Also described is a method for operating a driver assistance system for a vehicle..
07/17/14
20140199240
Anticancer agent
The invention relates to a method for preparing a bisphosphonate covalently bonded to a nanostructure. This invention also relates to a bisphosphonate having incorporated therein a radioisotope selected from 32p or 33p, preferably 33p, wherein the bisphosphonate is covalently bonded to a nanostructure directly or by way of a linker, and to the use thereof in a method of treating calcific tumours in a patient..
07/17/14
20140199235
Nanoparticle coated with ligand introduced with long hydrophobic chain and method for preparing same
The present invention relates to a nanoparticle having a linker connected to a long alkane or alkene chain, and a method for preparing the nanoparticle. The alkyl chain of c10-30 introduced with a ligand of the present invention can be coated on a hydrophobic nanoparticle through a noncovalent bond, enabling easy introduction of various ligands to the nanoparticle, and the nanoparticle having various functional groups prepared using the method can be applied to fluorescent detection, mri, raman spectroscopy, optical detection, pet, spect, or gamma image device, and the ligand of the visualization agents can be modified to be used for new vessels detection, cancer cell detection, immunocyte detection, hepatocyte detection, cell death detection, and gene detection..
07/17/14
20140197778
Temperature controlling system and method for battery
The present invention provides a temperature controlling system for a battery in an energy storage system, the temperature controlling system including: a converter comprising a plurality of switches and a converter inductor, the converter being configured to increase or decrease a voltage of the battery; a dc linker comprising first and second capacitors that are coupled in series and configured to stabilize an output voltage of the converter; and an inverter comprising a plurality of switches and an inductor, the inverter being configured to invert an input voltage, wherein the inverter further comprises a switch coupled between a terminal of the inductor and a first node between the first and second capacitors of the dc linker to provide a current from the inductor to the battery.. .
07/17/14
20140196894
Fluorescent tags for detection of swellable polymers
The invention is directed to stable crosslinked swellable fluorescently tagged polymeric microparticles, methods for making same, and their various uses. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into target zone and when the heat and/or suitable ph of the target zone cause degradation of the labile crosslinker and the microparticles expand.
07/17/14
20140196220
Cleaning compositions and emulsions or microemulsions employing extended chain nonionic surfactants
Synergistic combinations of extended chain surfactants and co-surfactants, emulsions or microemulsions and cleaning compositions incorporating the same are provided. In certain embodiments a surfactant system is disclosed which includes extended nonionic surfactants, and a linker surfactant.
07/10/14
20140194611
Stabilized nucleic acid dark quencher-fluorophore probes
The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support.
07/10/14
20140194383
Monomers capable of dimerizing in an aqueous solution, and methods of using same
Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g.
07/10/14
20140194327
Viscous fluid systems from waste water
By including a chemical additive in the well treatment fluid system design the cost and environmental impact of hydraulic fracturing may be substantially reduced. By adding a weak base to the well treatment fluid, water having a high, heterogeneous concentration of dissolved solids, such as water produced by oil and gas wells, may be utilized as the base fluid for hydraulic fracturing or other stimulation processes without adversely affecting the various components of the well treatment fluid.
07/10/14
20140193742
Block copolymer, manufacturing method therefor, and polymer electrolyte material, molded polymer electrolyte, and solid-polymer fuel cell using said block copolymer
The block copolymer of the present invention includes each one or more of: a segment (a1) containing an ionic group; a segment (a2) not containing an ionic group; and a linker moiety connecting the segments. The segment (a1) containing an ionic group comprises a constituent unit represented by a specific structure.
07/10/14
20140193437
Hydrophilic self-immolative linkers and conjugates thereof
The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker..
07/10/14
20140193436
Extracellular targeted drug conjugates
Extracellular-targeted drug conjugates (edc) in which a targeting moiety targeting a protein associated with the na,k-atpase is linked to a drug that interacts with the na,k-atpase through a linker a stable linker are useful in the treatment of disease and as tools for the evaluation of biological systems.. .
07/10/14
20140193416
Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficle polysaccaride ps-i, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools
The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the clostridium difficile glycopolymer ps-i and having the sequence of the pentasaccharide a-l-rhap-(1→3)-β-d-glcp-(1→4)-[a-l-rhap-(1→3]-a-d-glcp-(1→2)-a-d-glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker l for conjugation to a carrier protein or for immobilization on a surface.
07/10/14
20140193411
Multimeric constructs
Multimeric fusion proteins of an ig-like domain of flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins can be used therapeutically to block neovascularization in individuals with pathological conditions related to neovascularization.
07/10/14
20140193357
Derivatives of recombinant proteins, homo-multimers of granulocyte colony-stimulating factor and method of preparation thereof
The invention relates to derivatives of recombinant proteins, comprising homo-multimers of genetically fused recombinant biologically active protein monomer units, connected via selected peptide linker moiety; and the method of preparation thereof. Derivative of recombinant protein is preferably dimer of human granulocyte colony-stimulating factor, characterised by increased circulation time in vivo..
07/03/14
20140187668
Stabilizing additives for thermochromic pigments
A microencapsulation process is improved by adding a stabilizing agent that contains one or more catalytic organo-metal oxide materials, such as metal soaps. This functions as a crosslinker by causing unsaturated bonds in the microcapsule walls to react, thereby stabilizing the microcapsules against the effects of additives to coatings that, otherwise, degrade the functionality of thermochromic or photochromic materials at the microcapsule core..
07/03/14
20140187612
Method of modulating integrin mediated cellular activity and agents useful for same
An isolated nucleic acid encodes a polypeptide for inhibiting growth of a cancer cell. The amino acid sequence defines a binding domain of a β integrin subunit for erk2 map kinase, the binding domain comprising an intervening, centrally located amino acid linker sequence that links opposite terminal end amino acid sequence regions of the binding domain together and is non-essential for binding of the map kinase to the binding domain.
07/03/14
20140187502
Peptide linkers for polypeptide compositions and methods for using same
Disclosed herein are novel peptide linkers and polypeptide compositions comprising the linkers (e.g., chimeric polypeptides) and methods of using the polypeptide compositions. The compositions and methods are particularly useful for targeting/delivering a polypeptide or protein of interest (e.g., a therapeutic polypeptide) to a cell, tissue or organ of interest in order to treat various diseases or disorders (e.g., lysosomal storage disorders)..
07/03/14
20140187501
Targeted conjugates encapsulated in particles and formulations thereof
Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided.
07/03/14
20140187491
Relaxin fusion polypeptides and uses thereof
The present invention provides relaxin fusion polypeptides a-l-b with a non-wild type array of the relaxin a-chain and relaxin b-chain, wherein the a- and b-chains are connected by a linker peptide. The invention further provides relaxin fusion polypeptides with extended half-life.
07/03/14
20140186555
Topcoat compositions, coated substrates, and related methods
An aqueous based topcoating formulation is provided to coat various substrates such as those used in offset and electrographic printing devices. The water based coating formulation includes ethylene acrylic acid copolymer, polyethyleneimine, and a suitable crosslinker.
07/03/14
20140183089
Bisphenol a and aromatic glycidyl ether-free coatings
Disclosed are bisphenol a (bpa), bisphenol f, bisphenol a diglycidyl ether (badge), and bisphenol f diglycidyl ether (bfdge)-free coating compositions for metal substrates including an under-coat composition containing a polyester (co)polymer, and an under-coat cross-linker; and an over-coat composition containing a poly(vinyl chloride) (co)polymer dispersed in a substantially nonaqueous carrier liquid, an over-coat cross-linker, and a functional (meth)acrylic (co)polymer. Also provided is a method of coating a metal substrate using the bpa, bpf, badge and bfdge-free coating system to produce a hardened protective coating useful in fabricating metal storage containers.
06/26/14
20140179941
Synthesis and surface functionalization of particles
Provided are methods of controlling the shape and surface chemistry of nanoparticles, particularly ferrite nanoparticles. Methods for preparing non-spherical ferrite nanoparticles, including nanocubes, nanobars, nanoplates, and nanoflowers, are described.
06/26/14
20140179906
Conjugation methods
This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups.
06/26/14
20140179902
Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide.
06/26/14
20140179891
Interfacial processes for preparing photoactive additives
Different interfacial processes for producing photoactive additives are disclosed. Generally, the photoactive additives are formed from a photoactive moiety, a first linker moiety, and a diol chain extender.
06/26/14
20140179876
Permanent attachment of ammonium and guanidine-based antimicrobials to surfaces containing -oh functionality
Embodiments of the present disclosure relate to compounds, methods of making compositions (used as a linker or a linker moiety), structures having the compound covalently bonded to the surface of the structure, methods of attaching the compound to the surface of the structure having —oh functionality (e.g., calkyl-oh), methods of decreasing the amount of microorganisms formed on a structure, and the like.. .
06/26/14
20140179875
Sulfurization reagents on solid supports
Described herein are novel solid-supported sulfurization reagents having the general structure: (i) wherein (p) is a polymer; x is a linker; r1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and r2 is an alkyl group, an aryl group, a methyleneacyloxy group having the formula —ch2—o—c(o)—r7, a methylene carbonate group having the formula —ch2—o—c(o)—or8, or a methylene carbamate group having the formula —ch2—o—c(o)—nr9r10, wherein r7 is a c1 to c20 hydrocarbon residue, r8 is any alkyl, cycloalkyl, aryl, or heteroaryl, and r9 and r10 are independently hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl. Other embodiments include solid-supported sulfurization reagents having the structure of formula i, wherein (p) is a polystyrene-based solid support and x is an aromatic linker.
06/26/14
20140179751
Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins.
06/26/14
20140179735
Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymesp involved in the pathology of mycobacterium tuberculosis
A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological ph and have good bioavailability characteristics.
06/26/14
20140179711
Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
And crystalline forms thereof, wherein ar is aryl or heteroaryl, l is an optional alkylene linker, and r2, r3, r4, and r5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.. .
06/26/14
20140179547
Methods for the generation of multispecific and multivalent antibodies
The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a kappa constant domain and the other of a lambda constant domain.
06/26/14
20140178878
Oligonucleotids comprising a label associated through a linker
The present application discloses a labeled nucleotide comprising a label attached via a linker, wherein said labeled nucleotide has the formula wherein r1 is a residue with a negative net charge, preferably selected from the group consisting of a phosphate group, and a sulphate group; wherein r2, r3 and r4 are independently selected from the group consisting of h2, oh2, and o; wherein “n” is an integer between 0 and 16; wherein “a” is an integer between 1 and 10; wherein sp is absent or a spacer; wherein x is said label; and wherein y is a nucleotide or nucleoside. Furthermore, oligonucleotides comprising a labeled nucleotide according to the present invention and the use as a primer in amplification based methods is disclosed herein..
06/26/14
20140178416
Cross-linkers and their uses
Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.. .
06/26/14
20140178415
Maytansinoid derivatives
Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (abu), and maytansinoid drugs linked with an antigen binding unit (drug-linker-antigen binding unit: d-l-abu), for targeted delivery to disease tissues. D-l-abu, d-l-abu derivatives, and methods relating to the use of such drug conjugates to treat antigen positive cells in cancers and immunological disorders are provided..
06/26/14
20140178414
Maytansinoid derivatives
Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (abu), and maytansinoid drugs linked with an antigen binding unit (drug-linker-antigen binding unit: d-l-abu), for targeted delivery to disease tissues. D-l-abu, d-l-abu derivatives, and methods relating to the use of such drug conjugates to treat antigen positive cells in cancers and immunological disorders are provided..
06/26/14
20140178386
Functionalized polypeptides
The invention provides functionalized polypeptides, especially therapeutic polypeptides (e.g., scfv), comprising a linker sequence that can be rapidly and specifically functionalized by the addition of one or functional moieties (e.g., peg) or binding specificities (e.g., an amino acid sequence with a particular binding specificity). Such functionalized polypeptides are advantageous in that they have improved pharmacokinetic properties (e.g., improved in vivo half-life, tissue penetration and tissue residency time) over non-functionalized polypeptides.
06/26/14
20140178271
Cement clinker production with low emissions
The cement clinker production process is optimized from prior art by taking advantage of the exothermic reactions inside the sintering kiln and isolating them from the combustion process. Replacing traditional ways to burn fuels at the kiln discharge, avoiding combustion gases, dust recirculation and excess air inside the kiln by using alternative sources of heat if needed.
06/26/14
20140174743
Well treatment with complexed metal crosslinkers
Disclosed are compositions and methods for treating subterranean formations, in particular, oilfield stimulation compositions and methods using polymer viscosified fluid crosslinked with metal complexes with amino and/or phosphonic acids to provide an increased crosslinking temperature and a low ph sensitivity. The metal complexes can be used with borate crosslinkers to provide continuous viscosification as the temperature is increased..
06/26/14
20140174742
Well treatment with complexed metal crosslinkers
Disclosed are compositions and methods for treating subterranean formations, in particular, oilfield stimulation compositions and methods using polymer viscosified fluid crosslinked with metal complexes with amino and/or phosphonic acids to provide an increased crosslinking temperature and a low ph sensitivity. The metal complexes can be used with borate crosslinkers to provide continuous viscosification as the temperature is increased..
06/26/14
20140174325
Process for the production of a rapid hydraulic binder
A process for the production of a hydraulic binder, includes co-grinding a clinker and 0.1 to 5% by dry mass relative to the mass of clinker, of a material including more than 15% by mass of calcium silicate hydrate relative to the solid fraction of the material.. .
06/26/14
20140174324
Method and apparatus for baking clinker
To produce cement clinker by baking of raw meal in a kiln, use is conventionally made of a raw meal preheater in which the heat of the flue gas emerging from the kiln is transferred to the raw meal. In order to remove impurities which accumulate in circulation between the kiln and the raw meal preheater, a part of the flue gas is extracted from the kiln, bypassing the raw meal preheater.
06/19/14
20140172049
Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment
Nanoparticle-sized magnetic absorption enhancers (maes) exhibiting a controlled response to a magnetic field, including a controlled mechanical response and an inductive thermal response. The maes have a magnetic material that exhibits inductive thermal response to the magnetic field and is embedded in a coating, such that the mae conforms to a particular shape, e.g., hemisphere, dome or shell, chosen to produce the controlled mechanical response.
06/19/14
20140171635
Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers
Novel hydrazone-based fluorescent and pro-fluorescent reagents and linkers, including conjugationally extended hydrazine compositions, fluorescent hydrazone compositions, methods of the formation of hydrazones from the reaction of conjugationally extended hydrazines with conjugationally extended carbonyls, and methods of their use in assays systems are described. Use of these conjugationally compositions for direct colorimetric and fluorometric assays wherein a chromophore or the fluorophore is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule..
06/19/14
20140171633
Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene.
06/19/14
20140171622
Fusion proteins forming trimers
The present invention refers to fusion proteins comprising a neck region and carbohydrate recognition domain of a collectin trimerization domain, a linker element and an effector polypeptide. Further the invention refers to a nucleic acid encoding the said fusion protein.
06/19/14
20140171619
Peptide-crosslinked bioactive polymeric materials
A method for creating a peptide crosslinked bioactive polymeric material includes reacting a hydroxy-functionalized small molecule with a amino acid to form an amino acid functionalized monomer, reacting the amino acid functionalized monomer with a urea bond former to form a amino acid-based poly(ester urea), and reacting the amino acid-based poly(ester urea) with a peptide based crosslinker to form the peptide crosslinked bioactive polymeric material.. .
06/19/14
20140171542
Amphiphilic siloxane-containing vinylic monomers and uses thereof
The invention provides an amphiphilic siloxane-containing vinylic monomer which comprises one sole ethylenically unsaturated group and a siloxane-containing group covalently linked to the ethylenically-unsaturated group through a hydrophilic linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing vinylic monomer of the invention.
06/19/14
20140171539
Amphiphilic siloxane-containing (meth)acrylamides and uses thereof
The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention.
06/19/14
20140171486
Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene.
06/19/14
20140171375
Macromolecules
The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described..


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Linker topics: Crosslinker, Binding Agent, Monovalent, Polypeptide, Crystallin, Lead Selenide, Lead Sulfide, Lead Telluride, Quantum Dot, Transparent Electrode, Refraction, Virtual Machine, Relaxation, Tertiary Amine, Acrylamide

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