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|| List of recent Linker-related patents
| Alphabody libraries and methods for producing the same|
The invention provides single-chain alphabody library comprising at least 100 different-sequence single-chain alphabody polypeptides, wherein said alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the alphabody. The invention further provides methods for use of the alphabody libraries and alphabodies obtainable by the methods of the invention..
| Binding ligand linked drug delivery conjugates of tubulysins|
Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands.
| Template directed split and mix synthesis of small molecule libraries|
The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule l to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c)..
| Polypeptide linker and method of analyzing target material using the same|
A polypeptide linker comprising an antibody-binding region and an enzyme cleavage region, and related compositions, kits, and methods of using same.. .
| Perfluorinated compounds for the non-viral transfer of nucleic acids|
The invention relates to a compound of general formula (i): a-b-c(f, g′)-d-e-f-g-a′ or a structure of general formula (ii): a-b-c-(f′, g′)-d-b-e-f-g-a′ (ii), wherein -a is at least one molecule selected from the group of the perfluorocarbons (pfcs), perfluorinated silicon compounds, and/or further perfluorinated compounds, -b is at least one predetermined breaking point in the form of a physically, chemically, or enzymatically severable bond, -c is absent or at least one linker molecule, -d is absent or at least one spacer molecule, -e is at least one molecule selected from the group containing nucleobases, nucleosides, nucleotides, oligonucleotides, nucleic, acids, modified nucleobases, modified nucleosides, modified nucleotides, modified oligonucleotides, modified nucleic acids, monomers of peptide nucleic acids, oligomers or peptide nucleic acids and peptide nucleic acids or other nucleic acid analogs, -f, f′ is absent or at least one ligand, -g, g′ is absent or at least one marker molecule, -a′ is absent or has the meaning of a, and wherein the compounds i), ii), iii), iv), v), vi) are excluded. The invention farther relates to the use of said compound for the non-viral transfer of molecule e into a cell, to a pharmaceutical composition containing said compound, and to the use of said pharmaceutical composition..
| Targeted contrast agents and uses thereof|
Described herein is a contrast agent for administration to a subject. The contrast agent includes a targeting portion that includes an unchelated aminocarboxylate functional group; a metal ion bound to a metal-complexable portion; and a linker joining the targeting portion and the metal-complexable portion of the contrast agent.
| 99mtc imaging agents and methods of use|
Wherein r1 and r2 are independently an alkyl or cycloalkyl; r3 is and alkyl; x is co or so2; y is (ch2)n, c6h4, (och2ch2)n (nhch2ch2)n and (och2ch2ch2)n, or a combination thereof; z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.. .
| Cement clinker manufacturing plant|
A cement clinker manufacturing plant that includes a plant for producing purified syngas, obtained from solid waste, and process for transferring ash recovered from the ash pan of the gasifier to at least one inlet of the feedstock conversion device, which the plant includes, and/or of the furnace for the purpose of incorporating said ash into the feedstock; and a process for conveying the purified syngas to the main tuyere of the furnace and/or to at least one inlet of the feedstock conversion device.. .
| Metal-organic framework adsorbents for composite gas separation|
Metal-organic frameworks of the family m2 (2,5-dioxido-1,4-benzenedicarboxylate) wherein m=mg, mn, fe, co, cu, ni or zn are a group of porous crystalline materials formed of metal cations or clusters joined by multitopic organic linkers that can be used to isolate individual gases from a stream of combined gases. This group of adsorbant materials incorporates a high density of coordinatively-unsaturated mii centers lining the pore surfaces.
|Immunoconjugates with an intracellularly-cleavable linkage|
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.. .
|Multi-drug ligand conjugates|
Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands.
|Vitamin receptor binding drug delivery conjugates|
The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (l), and a drug.
|Coated fibrous based substrates|
Coated fibrous substrates the present invention provides a method of improving the adhesion of coatings to fibrous base materials. The method comprises treating a fibrous base material with one or more salt(s) of receptor species to provide a pre-coated fibrous base material comprising specific inorganic receptor sites within the fibrous base material.
|Peptide which can induce antibody capable of recognizing stereostructure of hiv|
An object of the present invention is to provide a peptide capable of inducing a superior or new neutralizing antibody against hiv, so that hiv infectious disease can be prevented and treated or a greater variety of preventive or therapeutic options can be offered. This object is achieved by using a peptide inducing an hiv's three-dimensional structure-recognizing antibody that recognizes a trimer region of c34, wherein three molecules of a derivative of a helical region c34 peptide at c-terminal region of transmembrane protein gp41 of an hiv particle are ligated via a c3-symmetric template compound having three equivalent linker structures..
|Compositions and methods for promoting the healing of tissue of multicellular organisms|
Compositions are provided for promoting healing of tissue of a vertebrate organism. The compositions can be for internal administration of a therapeutically effective amount of pharmacologically active, protease inhibiting, aqueous media soluble polysulfonated materials in salt form and associated with a secondary material to reduce one or more of inflammation, bacterial proliferation, proteolytic activity, and cancerous cell growth.
|Light-emitting diode devices|
An led device includes an led chip having a sapphire substrate, a first-type semiconductor layer on the substrate, a second-type semiconductor layer disposed on the first-type semiconductor layer, a first via hole passing through the sapphire substrate and the first-type semiconductor layer, a second via hole passing through the sapphire substrate, and an insulation layer coated on an inner wall of the first via hole; a transparent conductive layer made of electrically conductive material and formed on the second-type semiconductor layer; a cover layer formed on the transparent conductive layer; electrical conductors, each disposed within one of the via holes, wherein the electrical conductor in the first via hole is electrically connected to the second-type semiconductor layer and the electrical conductor in the second via hole is electrically connected to the first-type semiconductor layer; and two linkers for connection to external circuitry, formed on a surface of the sapphire.. .
|Water-absorbing polymer having a high absorption rate|
A process for producing a water-absorbing polymer composition, comprising the process steps of (i) mixing (α1) 0.1 to 99.999% by weight of ethylenically unsaturated monomers containing acid groups or salts thereof (α2) 0 to 70% by weight of polymerized, ethylenically unsaturated monomers copolymerizable with (α1), (α3) 0.001 to 10% by weight of one or more crosslinkers, (α4) 0 to 30% by weight of water-soluble polymers, and (α5) 0 to 20% by weight of one or more assistants, where the sum of their weights (α1) to (α5) is 100% by weight, (ii) free-radical polymerization with crosslinking to form a water-insoluble aqueous untreated hydrogel polymer, and surface postcrosslinking the ground hydrogel polymer wherein blowing agents having a particle size of 100 μm to 900 μm are added to the aqueous monomer solution prior to the addition of the initiator and the start of the free-radical polymerization.. .
|Biodegradable phosphoester polyamines|
Novel biodegradable phosphoester polyamines are disclosed. The biodegradable phosphoester polyamines may be utilized as cross-linkers for sprayable compositions which may be used as tissue adhesives or sealants..
|Method of producing functional molecule-containing silica nanoparticles on which biomolecules are bonded|
Allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded to coexist with carbodiimide and a biomolecule having an amino group in an aqueous solvent, thereby allowing formation of an amide bond between the carboxyl group active esterified by the carbodiimide, and the amino group of the biomolecule.. .
|Novel ferrocene labels for electrochemical assay and their use in analytical methods|
Compounds of general formula i are used as labels in an electrochemical assay: (i) in which: fc and fc′ are substituted or unsubstituted ferrocenyl moieties, x is a c1 to c6 alkylene chain which is optionally interrupted by —o— or —nh—; y is a c1 to c6 alkylene chain which is optionally interrupted by —o— or —nh—; z is a c1 to c12 alkylene chain which may optionally be substituted and/or may optionally be interrupted by —o—, —s—, cycloalkyl, —co—, —con r1—, —nr1co— or —nr1— in which r1 represents hydrogen or c1 to c4 alkyl; and r is a linker group. Compounds i are used to make labelled substrates, as well as functionalised compounds for making the labelled substrates..
|Auristatin drug linker conjugates|
Drug linker compounds and drug linker ligand conjugates are provided that have auristatins linked via the c-terminus. The conjugates show efficacy without the need for a self-immolative group to release the drug..
|Tissue grafted with a biodegradable polymer|
Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described.
|Scavenger receptor uptake for fabry disease enzyme replacement therapy|
The present invention relates to a composition comprising a lysosomal enzyme conjugated to a negatively charged scavenger receptor ligand. In some embodiments, the lysosomal enzyme is conjugated to the scavenger receptor ligand by way of a linker.
|Cohesive settable cement system|
A lightweight cross-linked gelled settable cement fluid system derived by pre-hydrating a water gelling agent, and then using that to mix with a cement blend which results in a very stable cement blend, which will matriculate through any fluid and not disperse, and form a cohesive plug wherever it comes to rest; wherein the fluid is injected at the bottom of the 10 pound/gal brine, and the fluid rises to the top of the brine where it reforms into a cohesive plug and hardens; and wherein the fluid can be applied to any density solution, and provide stability and cohesiveness to any settable plug; and wherein the cement/gelled water mixture is then cross-linked using standard hydraulic fracturing cross-linkers to provide a stable structure and ability to matriculate through another fluid and not disperse into that fluid. In a second embodiment the lightweight cross-linked gelled settable cement fluid which is cohesive and stable to be used as a balanced plug during cementing procedures to avoid the plug from becoming dilute in order to develop compressive strength, prevent fluid interchange from occurring and ensuring that all the cement placed would set in place..
|Hydration acceleration surfactants in conjunction with high molecular weight polymers, and methods and compositions relating thereto|
A hydration acceleration surfactant may be utilized in conjunction with high molecular weight polymers in forming high viscosity, aqueous based treatment fluids. Forming such fluids may involve mixing an aqueous base fluid, a hydration acceleration surfactant, a crosslinker polymer, and a base polymer, thereby yielding a treatment fluid, wherein the base polymer is provided in the form of a first polymeric emulsion before mixing and/or the crosslinker polymer is provided in the form of a second polymeric emulsion before mixing.
|Flexible wearable bands|
In one embodiment, the application discloses a connecting assembly for connecting a wearable band comprising at least one connector body, at least one linker, at least one slot, wherein the slot is configured on the connector body or configured on the linker; wherein the linker is configured to accept the protrusion to reversibly connect the linker to the connector body; and wherein the linker and the connector body comprise of material selected from silicone or a silicone composite. The connecting assembly may be used to carry or store personal and safety or security items..
|Method for selective derivatization of oligohistidine sequence of recombinant proteins|
Methods and compositions for the selective derivatization of a oligohistidine-tagged recombinant protein. A modifying compound comprised of an imidazole reactive group, a linker, and a ligating group is contacted with the recombinant protein, and a cooperative bond forms between the ligating group and the oligohistidine tag in the presence of a metal cation, and a covalent bond forms between the imidazole reactive group and an imidazole ring of the oligohistidine tag followed by the concomitant separation of the imidazole reactive group from the linker.
|Double click technology|
The present invention concerns a method of modifying the surface of a cellulosic material, wherein a modifying compound is attached to the cellulosic material through a linker, which linker is a conjugate that has been activated by functionalization prior to adsorption to form an activated conjugate, and wherein the entire method is carried out in aqueous media, as well as an intermediate product suitable for attaching to a modifying compound, the intermediate product comprising said functionalized conjugate linker that has been adsorbed to a cellulosic material.. .
|Mitochondrial compositions and uses thereof|
The present invention provides a compound of formula ia, wherein r1 is h or phosphate and the double bond is between n1 and c1 or between n2 and c1; r2 is a mitochondrial targeting moiety; r3 an alkyl, alkylaryl, alkylheteroaryl spacer group, a cleavable linker, or absent; r4 is h or an alkyl, aryl, or heteroaryl group; and r5 is alkyl, aryl, or heteroaryl; or n1 c1, and n3 together form a heterocyclic ring containing at least 5 atoms, wherein n1, n3, and r1-r5 are as defined above, or n3 and r5 together form a heterocyclic ring containing at least four atoms; or a pharmaceutically acceptable salt or prodrug thereof.. .
|Serpin-finger fusion polypeptide|
The current invention comprises a fusion polypeptide comprising a serpin-finger polypeptide conjugated to a biologically active polypeptide optionally via a peptidic linker polypeptide. Another aspect is a protein complex of the serpin-finger fusion polypeptide and a serpin, wherein the fusion polypeptide is incorporated in the serpin into the middle of beta-sheet a as strand 4a.
|Directed synthesis of oligophosphoramidate stereoisomers|
The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: in the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker.
|Process for producing improved absorbent polymers by means of cryogenic grinding|
A process for producing a water-absorbing polymer comprises: (i) mixing (α1) 0.1-99.99% by weight of ethylenically unsaturated monomers containing acid groups or salts thereof, or ethylenically unsaturated monomers including a protonated or quaternized nitrogen, or mixtures thereof, (α2) 0-70% by weight of ethylenically unsaturated monomers copolymerizable with (α1), (α3) 0.001-10% by weight of one or more crosslinkers, (α4) 0-30% by weight of water-soluble polymers, and (α5) 0-20% by weight of one or more assistants, where the sum of the weights (α1) to (α5) is 100%; (ii) free-radical polymerization with crosslinking to form an untreated hydrogel polymer; (iii) coarse comminution of the untreated hydrogel polymer to give pieces having a diameter from 0.1 mm to 5.0 cm; (iv) cooling and grinding the untreated hydrogel polymer; (v) drying the untreated hydrogel polymer after grinding at a temperature from 85° c. To 260° c.; (vi) postcrosslinking the hydrogel polymer and (vii) drying the water-absorbing polymer..
|Hydroxymethyl linkers for labeling nucleotides|
The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods.
|Fluorinated structured organic film photoreceptor layers containing fluorinated secondary components|
A imaging member, such as a photoreceptor, having an outermost layer that is a structured organic film (sof) comprising a plurality of segments and a plurality of linkers including a first fluorinated segment, a second electroactive segment and fluorinated secondary components.. .
|Structured organic film photoreceptor layers containing fluorinated secondary components|
An imaging member, such as a photoreceptor, having an outermost layer that is a structured organic film (sof) comprising a plurality of segments and a plurality of linkers including at least one electroactive segment and an effective amount of fluorinated secondary components.. .
|Cyclodextrin-based polymers for therapeutics delivery|
The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo.
|Hybrid thermoplastic gels and their methods of making|
Methods, compositions, apparatuses, and systems are provided for a hybrid thermoplastic gel or sealant. The methods comprise providing (a) a base polymer having at least one functional group capable of crosslinking, (b) a functionalized extender, and (c) heat, and reacting the base polymer and functionalized extender in the presence of the heat to form the hybrid thermoplastic gel.
|Reduced caustic laundry detergents based on extended chain surfactants|
The invention discloses synergistic combinations of surfactants blends and cleaning composition. In certain embodiments a surfactant system is disclosed which includes extended anionic surfactants, linker surfactants, and a multiply charged cation component.
|Alkyl ether compositions and methods of use|
A polymer includes a linker represented by formula i ([or1och2or2och2]m), where r1 and r2 are, independently, alkylene, alkenylene, arylene, heteroarylene, or alkylarylalkylene; and the polymer has a weight average molecular weight of about 500 g/mol to about 2,000,000 g/mol, and m is 1 to 1000.. .
|Cancer imaging and treatment|
Wherein: p1 and p2, which may be the same or different, are cyclic oligopeptide moieties, at least one of p1 and p2 having the motif b-arg or b-(me)arg within the cyclic moiety, wherein b is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; s1 and s2 are spacer groups, which may be the same or different; l is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (p1-s1j) moieties or multiple (s2q-p2) moieties.. .
Dental composition comprising (i) a particulate filler; (ii) a polymerizable hydrolysis-stable compound of the following formula (1) axn wherein a is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, x are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of a, which x may be the same or different and are represented by the following formula (2) wherein r1 and r2 are independent from each other and represent a hydrogen atom, a c1-6 alkyl group or a group —(ch2)m—z, wherein z is coom, opo3m2, po3m2, so3m, and m is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, l is a bond, a c1-6 alkylene group; and n is an integer of at least 1; provided that at least one x cannot be a (meth)acryl group; and (iii) an initiator system.. .
Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein a is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the termini forms an amide bond with an x moiety; wherein r′ represents a hydrogen atom or a substituted or unsubstituted aliphatic or cycloaliphatic hydrocarbon group, wherein each r may be the same or different l1, l2, and l3 which may be the same or different, independently represent a single bond, or a c2-20 straight-chain, branched or cyclic hydrocarbon group optionally containing from 1 to 6 heteroatoms selected from nitrogen and oxygen in the backbone of the hydrocarbon group, and optionally from 1 to 6 functional groups selected from carboxylic acid groups or a salt thereof, hydroxyl groups, thiol groups and amino groups, and in case a plurality of l1 and l2 are present, each of l1 and l2 may be the same or different; q1 and q2, which may be the same or different, independently represent a single bond or a linkage selected from an amide, a urethane, a urea and a thiourea linkage; k is an integer of at least 0, x are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of a, wherein each x may be the same or different and are represented by the following formula (2): wherein r1 and r2 are independent from each other and represent a hydrogen atom, a c1-6 alkyl group or a group —(ch2)m—coom, wherein m represents a hydrogen atom or a metal atom, m is an integer of from 0 to 6, l is a bond or a c1-6 alkylene group; and n is an integer of at least 2; (ii) an initiator system; optionally a polyacidic polymer; optionally water and/or a water soluble solvent; and optionally a particulate filler.. .
|Site-specific labeling of affinity tags in fusion proteins|
The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula a(b)n, wherein a is a fluorophore, b is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody.
|Cis reactive oxygen quenchers integrated into linkers|
The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates..
|System for purifying, producing and storing biomolecules|
The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support.
|Redox responsive polymeric nanocapsules for protein delivery|
The invention provides methods of making and using compositions comprising a polymer shell designed to deliver polypeptides to selected environments. In embodiments of the invention, different environmental conditions are harnessed to allow the selective degradation of the polymer shell and the consequential release of one or polypeptides encapsulated therein.
|Systems, methods, and devices for in vivo delivery using remote actuation of implantable hydrogel mems devices|
Microelectromechanical system (mems) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., pegda), which are photopolymerizable in the presence of crosslinkers and photoinitiators.
|Beta-glucuronide-linker drug conjugates|
Ligand drug conjugate compounds comprising a β-glucuronide-based linker and methods of using such compounds are provided.. .
|Method of protein purification|
A method for producing a target protein is provided, which includes steps described below. A crude extract including a fusion protein is provided.
|Polycarbonate block copolymers|
The disclosure pertains to amphiphilic block copolymers comprising an aliphatic polycarbonate chain coupled to a hydrophilic polymer. Such amphiphilic polymers may have the formula a-l-b, where a- is a polycarbonate or polyethercarbonate chain having from about 3 to about 500 repeating units, l is a linker moiety and —b is a hydrophilic oligomer having from about 4 to about 200 repeating units.
|6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides|
Wherein r1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by r1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and r2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above..
|Mutant protease biosensors with enhanced detection characteristics|
A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the c-terminal portion of the thermostable luciferase to the n-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase.
|Vaccines directed to langerhans cells|
The present invention includes isolated anti-langerin vaccines, methods for making and using an isolated anti-langerin antibody or binding fragment thereof and one or more antigenic peptides at the carboxy-terminus of the isolated anti-langerin antibody, wherein when two or more antigenic peptides are present, the peptides are separated by the one or more linker peptides that comprise at least one glycosylation site. The present invention also includes isolated vectors for the expression of the anti-langerin antigen delivery vectors and their manufactures and use..
|Recombinant fusion interferon for animals|
A recombinant fusion interferon for animals. The recombinant fusion interferon comprises an animal interferon and a fc region of an animal immunoglobulin g (igg).
|Microfluidic devices having solvent-resistant coating and method of manufacture thereof|
A method of coating a substrate, such as a microfluidic device having an interior surface, includes heating a gas including a perfluoroacrylate, a crosslinker and an initiator at a first temperature, maintaining the substrate at a second temperature lower than the first temperature in a reaction chamber, exposing the heated gas to the substrate in the reaction chamber, and reacting the perfluoroacrylate with the initiator and crosslinker to form a polymer coating on the surface of the substrate.. .
|Alignment of nanomaterials and micromaterials|
The present invention provides a method for preparing a nanoassembly that includes the step of reacting the assembly template with at least one nanomaterial to form the nanoassembly using a bifunctional linker.. .
|Nanostructured physically-associating hydrogels for injectable, responsive, and tough biomaterials|
Described herein are block copolymer conjugates that form double-network hydrogels under appropriate conditions. The conjugates comprise a block of polymer end-group, a block of self-associating peptide or protein, and flexible linkers between the two.
|Surrogates of post-translationally modified proteins and uses thereof|
The present invention provides compounds that are surrogates of post-translationally modified proteins and uses thereof. Numerous diseases are associated with post-translationally modified proteins that are difficult to obtain in homogenous form and in quantities needed for immunization and use as convenient standards, calibrators, and/or reference compounds that facilitate the detection and analysis of endogenous post-translationally modified proteins.
|Methods of use of calcium hexa aluminate refractory linings and/or chemical barriers in high alkali or alkaline environments|
A method for improving the insulating character/and or penetration resistance of a surface comprising lining a surface of a lime kiln, a cement kiln, a roasting kiln, a thermal oxidizer, or a fluidized bed reactor that is subject to wear by an alkali environment and/or an alkaline environment with a refractory composition comprising a refractory aggregate consisting essentially of a calcium hexa aluminate clinker having the formula ca6, wherein c is equal to calcium oxide, wherein a is equal to aluminum oxide, and wherein the hexa aluminate clinker has from zero to less than about fifty weight percent c12a7, and wherein greater than 98 weight percent of the calcium hexa aluminate clinker having a particle size ranging from −20 microns to +3 millimeters, for forming a liner of the surface.. .
|Cyclic peptide and conjugate thereof for binding to keratinocytes|
A cyclic peptide capable of binding specifically to the α2 i domain of a collagen binding integrin receptor may be conjugated to a drug containing particle via a linker moiety. The conjugate may be used to target a therapeutic drug to a cell expressing a collagen binding integrin receptor on its surface..
|Novel maytansinoid derivatives with sulfoxide linker|
The invention relates to novel maytansinoid compounds having sulfoxide linkers and more specifically to novel maytansinoid compounds of structural formula (i) and (ii). The invention also provides conjugates of the maytansinoid compounds linked to a cell-binding agent.
|Contrast agent for photoacoustic imaging and photoacoustic imaging method using the same|
(wherein mnp represents a particle containing an iron oxide particle; l represents a linker molecule; p represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.. .
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Linker topics: Crosslinker, Binding Agent, Monovalent, Polypeptide, Crystallin, Lead Selenide, Lead Sulfide, Lead Telluride, Quantum Dot, Transparent Electrode, Refraction, Virtual Machine, Relaxation, Tertiary Amine, Acrylamide
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