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Temperature controlling system and method for battery

Date/App# patent app List of recent Linker-related patents
07/17/14
20140200798
 Driver assistance system and method for operating a driver assistance system patent thumbnailDriver assistance system and method for operating a driver assistance system
A driver assistance system for a vehicle including: a detection device for detecting the vehicle surroundings, a position determination device for determining a vehicle position relative to the vehicle surroundings, a database having an ontological data structure in which traffic rules are implemented, a linker for linking the detected vehicle surroundings and the vehicle position to the ontological data structure to form a linked data structure, and an evaluator for evaluating the linked data structure. Also described is a method for operating a driver assistance system for a vehicle..
07/17/14
20140199240
 Anticancer agent patent thumbnailAnticancer agent
The invention relates to a method for preparing a bisphosphonate covalently bonded to a nanostructure. This invention also relates to a bisphosphonate having incorporated therein a radioisotope selected from 32p or 33p, preferably 33p, wherein the bisphosphonate is covalently bonded to a nanostructure directly or by way of a linker, and to the use thereof in a method of treating calcific tumours in a patient..
07/17/14
20140199235
 Nanoparticle coated with ligand introduced with long hydrophobic chain and method for preparing same patent thumbnailNanoparticle coated with ligand introduced with long hydrophobic chain and method for preparing same
The present invention relates to a nanoparticle having a linker connected to a long alkane or alkene chain, and a method for preparing the nanoparticle. The alkyl chain of c10-30 introduced with a ligand of the present invention can be coated on a hydrophobic nanoparticle through a noncovalent bond, enabling easy introduction of various ligands to the nanoparticle, and the nanoparticle having various functional groups prepared using the method can be applied to fluorescent detection, mri, raman spectroscopy, optical detection, pet, spect, or gamma image device, and the ligand of the visualization agents can be modified to be used for new vessels detection, cancer cell detection, immunocyte detection, hepatocyte detection, cell death detection, and gene detection..
07/17/14
20140197778
 Temperature controlling system and method for battery patent thumbnailTemperature controlling system and method for battery
The present invention provides a temperature controlling system for a battery in an energy storage system, the temperature controlling system including: a converter comprising a plurality of switches and a converter inductor, the converter being configured to increase or decrease a voltage of the battery; a dc linker comprising first and second capacitors that are coupled in series and configured to stabilize an output voltage of the converter; and an inverter comprising a plurality of switches and an inductor, the inverter being configured to invert an input voltage, wherein the inverter further comprises a switch coupled between a terminal of the inductor and a first node between the first and second capacitors of the dc linker to provide a current from the inductor to the battery.. .
07/17/14
20140196894
 Fluorescent tags for detection of swellable polymers patent thumbnailFluorescent tags for detection of swellable polymers
The invention is directed to stable crosslinked swellable fluorescently tagged polymeric microparticles, methods for making same, and their various uses. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into target zone and when the heat and/or suitable ph of the target zone cause degradation of the labile crosslinker and the microparticles expand.
07/17/14
20140196220
 Cleaning compositions and emulsions or microemulsions employing extended chain nonionic surfactants patent thumbnailCleaning compositions and emulsions or microemulsions employing extended chain nonionic surfactants
Synergistic combinations of extended chain surfactants and co-surfactants, emulsions or microemulsions and cleaning compositions incorporating the same are provided. In certain embodiments a surfactant system is disclosed which includes extended nonionic surfactants, and a linker surfactant.
07/10/14
20140194611
 Stabilized nucleic acid dark quencher-fluorophore probes patent thumbnailStabilized nucleic acid dark quencher-fluorophore probes
The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support.
07/10/14
20140194383
 Monomers capable of dimerizing in an aqueous solution, and methods of using same patent thumbnailMonomers capable of dimerizing in an aqueous solution, and methods of using same
Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g.
07/10/14
20140194327
 Viscous fluid systems from waste water patent thumbnailViscous fluid systems from waste water
By including a chemical additive in the well treatment fluid system design the cost and environmental impact of hydraulic fracturing may be substantially reduced. By adding a weak base to the well treatment fluid, water having a high, heterogeneous concentration of dissolved solids, such as water produced by oil and gas wells, may be utilized as the base fluid for hydraulic fracturing or other stimulation processes without adversely affecting the various components of the well treatment fluid.
07/10/14
20140193742
 Block copolymer, manufacturing method therefor, and polymer electrolyte material, molded polymer electrolyte, and solid-polymer fuel cell using said block copolymer patent thumbnailBlock copolymer, manufacturing method therefor, and polymer electrolyte material, molded polymer electrolyte, and solid-polymer fuel cell using said block copolymer
The block copolymer of the present invention includes each one or more of: a segment (a1) containing an ionic group; a segment (a2) not containing an ionic group; and a linker moiety connecting the segments. The segment (a1) containing an ionic group comprises a constituent unit represented by a specific structure.
07/10/14
20140193437
Hydrophilic self-immolative linkers and conjugates thereof
The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker..
07/10/14
20140193436
Extracellular targeted drug conjugates
Extracellular-targeted drug conjugates (edc) in which a targeting moiety targeting a protein associated with the na,k-atpase is linked to a drug that interacts with the na,k-atpase through a linker a stable linker are useful in the treatment of disease and as tools for the evaluation of biological systems.. .
07/10/14
20140193416
Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficle polysaccaride ps-i, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools
The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the clostridium difficile glycopolymer ps-i and having the sequence of the pentasaccharide a-l-rhap-(1→3)-β-d-glcp-(1→4)-[a-l-rhap-(1→3]-a-d-glcp-(1→2)-a-d-glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker l for conjugation to a carrier protein or for immobilization on a surface.
07/10/14
20140193411
Multimeric constructs
Multimeric fusion proteins of an ig-like domain of flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins can be used therapeutically to block neovascularization in individuals with pathological conditions related to neovascularization.
07/10/14
20140193357
Derivatives of recombinant proteins, homo-multimers of granulocyte colony-stimulating factor and method of preparation thereof
The invention relates to derivatives of recombinant proteins, comprising homo-multimers of genetically fused recombinant biologically active protein monomer units, connected via selected peptide linker moiety; and the method of preparation thereof. Derivative of recombinant protein is preferably dimer of human granulocyte colony-stimulating factor, characterised by increased circulation time in vivo..
07/03/14
20140187668
Stabilizing additives for thermochromic pigments
A microencapsulation process is improved by adding a stabilizing agent that contains one or more catalytic organo-metal oxide materials, such as metal soaps. This functions as a crosslinker by causing unsaturated bonds in the microcapsule walls to react, thereby stabilizing the microcapsules against the effects of additives to coatings that, otherwise, degrade the functionality of thermochromic or photochromic materials at the microcapsule core..
07/03/14
20140187612
Method of modulating integrin mediated cellular activity and agents useful for same
An isolated nucleic acid encodes a polypeptide for inhibiting growth of a cancer cell. The amino acid sequence defines a binding domain of a β integrin subunit for erk2 map kinase, the binding domain comprising an intervening, centrally located amino acid linker sequence that links opposite terminal end amino acid sequence regions of the binding domain together and is non-essential for binding of the map kinase to the binding domain.
07/03/14
20140187502
Peptide linkers for polypeptide compositions and methods for using same
Disclosed herein are novel peptide linkers and polypeptide compositions comprising the linkers (e.g., chimeric polypeptides) and methods of using the polypeptide compositions. The compositions and methods are particularly useful for targeting/delivering a polypeptide or protein of interest (e.g., a therapeutic polypeptide) to a cell, tissue or organ of interest in order to treat various diseases or disorders (e.g., lysosomal storage disorders)..
07/03/14
20140187501
Targeted conjugates encapsulated in particles and formulations thereof
Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided.
07/03/14
20140187491
Relaxin fusion polypeptides and uses thereof
The present invention provides relaxin fusion polypeptides a-l-b with a non-wild type array of the relaxin a-chain and relaxin b-chain, wherein the a- and b-chains are connected by a linker peptide. The invention further provides relaxin fusion polypeptides with extended half-life.
07/03/14
20140186555
Topcoat compositions, coated substrates, and related methods
An aqueous based topcoating formulation is provided to coat various substrates such as those used in offset and electrographic printing devices. The water based coating formulation includes ethylene acrylic acid copolymer, polyethyleneimine, and a suitable crosslinker.
07/03/14
20140183089
Bisphenol a and aromatic glycidyl ether-free coatings
Disclosed are bisphenol a (bpa), bisphenol f, bisphenol a diglycidyl ether (badge), and bisphenol f diglycidyl ether (bfdge)-free coating compositions for metal substrates including an under-coat composition containing a polyester (co)polymer, and an under-coat cross-linker; and an over-coat composition containing a poly(vinyl chloride) (co)polymer dispersed in a substantially nonaqueous carrier liquid, an over-coat cross-linker, and a functional (meth)acrylic (co)polymer. Also provided is a method of coating a metal substrate using the bpa, bpf, badge and bfdge-free coating system to produce a hardened protective coating useful in fabricating metal storage containers.
06/26/14
20140179941
Synthesis and surface functionalization of particles
Provided are methods of controlling the shape and surface chemistry of nanoparticles, particularly ferrite nanoparticles. Methods for preparing non-spherical ferrite nanoparticles, including nanocubes, nanobars, nanoplates, and nanoflowers, are described.
06/26/14
20140179906
Conjugation methods
This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups.
06/26/14
20140179902
Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide.
06/26/14
20140179891
Interfacial processes for preparing photoactive additives
Different interfacial processes for producing photoactive additives are disclosed. Generally, the photoactive additives are formed from a photoactive moiety, a first linker moiety, and a diol chain extender.
06/26/14
20140179876
Permanent attachment of ammonium and guanidine-based antimicrobials to surfaces containing -oh functionality
Embodiments of the present disclosure relate to compounds, methods of making compositions (used as a linker or a linker moiety), structures having the compound covalently bonded to the surface of the structure, methods of attaching the compound to the surface of the structure having —oh functionality (e.g., calkyl-oh), methods of decreasing the amount of microorganisms formed on a structure, and the like.. .
06/26/14
20140179875
Sulfurization reagents on solid supports
Described herein are novel solid-supported sulfurization reagents having the general structure: (i) wherein (p) is a polymer; x is a linker; r1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and r2 is an alkyl group, an aryl group, a methyleneacyloxy group having the formula —ch2—o—c(o)—r7, a methylene carbonate group having the formula —ch2—o—c(o)—or8, or a methylene carbamate group having the formula —ch2—o—c(o)—nr9r10, wherein r7 is a c1 to c20 hydrocarbon residue, r8 is any alkyl, cycloalkyl, aryl, or heteroaryl, and r9 and r10 are independently hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl. Other embodiments include solid-supported sulfurization reagents having the structure of formula i, wherein (p) is a polystyrene-based solid support and x is an aromatic linker.
06/26/14
20140179751
Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins.
06/26/14
20140179735
Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymesp involved in the pathology of mycobacterium tuberculosis
A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological ph and have good bioavailability characteristics.
06/26/14
20140179711
Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
And crystalline forms thereof, wherein ar is aryl or heteroaryl, l is an optional alkylene linker, and r2, r3, r4, and r5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.. .
06/26/14
20140179547
Methods for the generation of multispecific and multivalent antibodies
The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a kappa constant domain and the other of a lambda constant domain.
06/26/14
20140178878
Oligonucleotids comprising a label associated through a linker
The present application discloses a labeled nucleotide comprising a label attached via a linker, wherein said labeled nucleotide has the formula wherein r1 is a residue with a negative net charge, preferably selected from the group consisting of a phosphate group, and a sulphate group; wherein r2, r3 and r4 are independently selected from the group consisting of h2, oh2, and o; wherein “n” is an integer between 0 and 16; wherein “a” is an integer between 1 and 10; wherein sp is absent or a spacer; wherein x is said label; and wherein y is a nucleotide or nucleoside. Furthermore, oligonucleotides comprising a labeled nucleotide according to the present invention and the use as a primer in amplification based methods is disclosed herein..
06/26/14
20140178416
Cross-linkers and their uses
Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.. .
06/26/14
20140178415
Maytansinoid derivatives
Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (abu), and maytansinoid drugs linked with an antigen binding unit (drug-linker-antigen binding unit: d-l-abu), for targeted delivery to disease tissues. D-l-abu, d-l-abu derivatives, and methods relating to the use of such drug conjugates to treat antigen positive cells in cancers and immunological disorders are provided..
06/26/14
20140178414
Maytansinoid derivatives
Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (abu), and maytansinoid drugs linked with an antigen binding unit (drug-linker-antigen binding unit: d-l-abu), for targeted delivery to disease tissues. D-l-abu, d-l-abu derivatives, and methods relating to the use of such drug conjugates to treat antigen positive cells in cancers and immunological disorders are provided..
06/26/14
20140178386
Functionalized polypeptides
The invention provides functionalized polypeptides, especially therapeutic polypeptides (e.g., scfv), comprising a linker sequence that can be rapidly and specifically functionalized by the addition of one or functional moieties (e.g., peg) or binding specificities (e.g., an amino acid sequence with a particular binding specificity). Such functionalized polypeptides are advantageous in that they have improved pharmacokinetic properties (e.g., improved in vivo half-life, tissue penetration and tissue residency time) over non-functionalized polypeptides.
06/26/14
20140178271
Cement clinker production with low emissions
The cement clinker production process is optimized from prior art by taking advantage of the exothermic reactions inside the sintering kiln and isolating them from the combustion process. Replacing traditional ways to burn fuels at the kiln discharge, avoiding combustion gases, dust recirculation and excess air inside the kiln by using alternative sources of heat if needed.
06/26/14
20140174743
Well treatment with complexed metal crosslinkers
Disclosed are compositions and methods for treating subterranean formations, in particular, oilfield stimulation compositions and methods using polymer viscosified fluid crosslinked with metal complexes with amino and/or phosphonic acids to provide an increased crosslinking temperature and a low ph sensitivity. The metal complexes can be used with borate crosslinkers to provide continuous viscosification as the temperature is increased..
06/26/14
20140174742
Well treatment with complexed metal crosslinkers
Disclosed are compositions and methods for treating subterranean formations, in particular, oilfield stimulation compositions and methods using polymer viscosified fluid crosslinked with metal complexes with amino and/or phosphonic acids to provide an increased crosslinking temperature and a low ph sensitivity. The metal complexes can be used with borate crosslinkers to provide continuous viscosification as the temperature is increased..
06/26/14
20140174325
Process for the production of a rapid hydraulic binder
A process for the production of a hydraulic binder, includes co-grinding a clinker and 0.1 to 5% by dry mass relative to the mass of clinker, of a material including more than 15% by mass of calcium silicate hydrate relative to the solid fraction of the material.. .
06/26/14
20140174324
Method and apparatus for baking clinker
To produce cement clinker by baking of raw meal in a kiln, use is conventionally made of a raw meal preheater in which the heat of the flue gas emerging from the kiln is transferred to the raw meal. In order to remove impurities which accumulate in circulation between the kiln and the raw meal preheater, a part of the flue gas is extracted from the kiln, bypassing the raw meal preheater.
06/19/14
20140172049
Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment
Nanoparticle-sized magnetic absorption enhancers (maes) exhibiting a controlled response to a magnetic field, including a controlled mechanical response and an inductive thermal response. The maes have a magnetic material that exhibits inductive thermal response to the magnetic field and is embedded in a coating, such that the mae conforms to a particular shape, e.g., hemisphere, dome or shell, chosen to produce the controlled mechanical response.
06/19/14
20140171635
Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers
Novel hydrazone-based fluorescent and pro-fluorescent reagents and linkers, including conjugationally extended hydrazine compositions, fluorescent hydrazone compositions, methods of the formation of hydrazones from the reaction of conjugationally extended hydrazines with conjugationally extended carbonyls, and methods of their use in assays systems are described. Use of these conjugationally compositions for direct colorimetric and fluorometric assays wherein a chromophore or the fluorophore is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule..
06/19/14
20140171633
Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene.
06/19/14
20140171622
Fusion proteins forming trimers
The present invention refers to fusion proteins comprising a neck region and carbohydrate recognition domain of a collectin trimerization domain, a linker element and an effector polypeptide. Further the invention refers to a nucleic acid encoding the said fusion protein.
06/19/14
20140171619
Peptide-crosslinked bioactive polymeric materials
A method for creating a peptide crosslinked bioactive polymeric material includes reacting a hydroxy-functionalized small molecule with a amino acid to form an amino acid functionalized monomer, reacting the amino acid functionalized monomer with a urea bond former to form a amino acid-based poly(ester urea), and reacting the amino acid-based poly(ester urea) with a peptide based crosslinker to form the peptide crosslinked bioactive polymeric material.. .
06/19/14
20140171542
Amphiphilic siloxane-containing vinylic monomers and uses thereof
The invention provides an amphiphilic siloxane-containing vinylic monomer which comprises one sole ethylenically unsaturated group and a siloxane-containing group covalently linked to the ethylenically-unsaturated group through a hydrophilic linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing vinylic monomer of the invention.
06/19/14
20140171539
Amphiphilic siloxane-containing (meth)acrylamides and uses thereof
The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention.
06/19/14
20140171486
Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene.
06/19/14
20140171375
Macromolecules
The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described..
06/19/14
20140170769
Microscope apparatus for detecting or imaging protein using probe for intrinsic fluorescence resonance energy transfer and method for detecting or imaging protein using the same
A microscope apparatus for detecting or imaging a target protein using a probe for intrinsic fluorescence resonance energy transfer (ifret) according to the present invention comprises: a light irradiation unit that irradiates a first light having a wavelength range for exciting an amino acid in the target protein and a second light having a wavelength range for exciting a fluorescent molecule of the probe for ifret; an objective lens that allows the lights irradiated from the light irradiation unit to be incident onto a sample into which the probe for ifret is introduced; and a recognition unit that detects a first light emitting signal generated from the probe for ifret by irradiating the first light having a wavelength range for exciting an amino acid in the target protein onto the sample and a second light emitting signal generated from the probe for ifret by irradiating the second light having a wavelength range for exciting a fluorescent molecule of the probe for ifret onto the sample, wherein the probe for ifret includes: a binding site specific to a target protein or a molecule which has the binding site; and a fluorescent molecule having an acceptor function with respect to intrinsic fluorescence of the target protein, which are bonded to each other directly or by a linker.. .
06/19/14
20140170767
Method for diagnosing biomarkers and biomarker diagnosis kit
A method for diagnosing a biomarker using magnetic particles and quantum dots for quantitative analysis and a biomarker diagnosis kit are provided. The method for diagnosing a biomarker includes: ii) providing magnetic particles having surfaces to which a primary antibody capable of collecting a biomarker using a linker is fixed; ii) providing quantum dots having surfaces to which a secondary antibody capable of detecting the biomarker is fixed; iii) sandwich-targeting the biomarker by the magnetic particles and the quantum dots; iv) selectively separating quantum dots sandwich-targeting the biomarker among the quantum dots; and v) quantifying the concentration of the biomarker by measuring absorbance or intensity of fluorescence of separated quantum dots..
06/19/14
20140170711
Nucleotide analogs and process for making same enzyme
A process for making a nucleotide analog includes combining a first substrate that includes a linker and a base with a second substrate to form a substrate composition. An enzyme contacts the substrate composition and catalyzes formation of the nucleotide analog from the first substrate and the second substrate.
06/19/14
20140170326
Thermally crosslinking polyacrylates and process for their preparation
Crosslinker-accelerator system for the thermal crosslinking of polyacrylates with functional groups suitable for entering into linking reactions with cyclic ethers, more particularly epoxide groups or oxetane groups, comprising at least one substance containing epoxide or oxetane groups (crosslinker) and at least one substance with an accelerating action for the linking reaction at a temperature below the melting temperature of the polyacrylate (accelerator).. .
06/19/14
20140170224
Gelatin-based microgels
A gelatin-based microgel was prepared by a simple method starting from gelatin and alginate. The microgel was composed of a soft gelatin-based core coated by a permeable membrane.
06/19/14
20140170183
D-amino acid derivative-modified peptidoglycan and methods of use thereof
The present disclosure provides modified bacteria and modified peptidoglycan comprising modified d-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified d-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group.
06/12/14
20140165222
High affinity sumo traps
The potential use of these “sumo receptors” to isolate sumoylated targets has been considered using the sim sequences of the sumo-dependent ubiquitin-protein ligase rnf4. Rfn4 contains 4 sim sequences known to interact with sumoylated proteins.
06/12/14
20140163253
Hydrolysable linkers and cross-linkers for absorbable polymers
The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates..
06/12/14
20140163229
Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same
Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s).
06/12/14
20140163211
68ga generator
The present invention relates to a 68ga generator, wherein the 68ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68ga, the triethoxyphenyl group being covalently bound to a support material through a linker.. .
06/12/14
20140163165
Low molecular weight products and use thereof as reversible or permanent low-temperature crosslinking agent in diels-alder reactions
The invention relates to low molecular mass products and to the use thereof as reversible or permanent low-temperature crosslinkers in diels-alder reactions.. .
06/12/14
20140163128
Polyurethane composite materials
Polymeric composite materials, particularly highly filled polyurethane composite materials are described herein. Such highly filled polyurethane composite materials may be formed by reaction and extrusion of one or more polyols, one or more di- or poly-isocyanates, and from about 45 to about 85 weight percent of inorganic filler such as fly ash.
06/12/14
20140163042
Enzyme inhibitors
Compounds of formula (i) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein r1 is a carboxylic acid group (—cooh), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; r2 is the side chain of a natural or non-natural alpha amino acid; y is a bond, —c(═o), —s(═o)2—, —c(═o)o—, —c(o)nr3—, —c(═s)—nr3, —c(═nh)nr3 or —s(═o)2nr3— wherein r3 is hydrogen or optionally substituted c1-c6 alkyl; l1 is a divalent radical of formula -(alk1)m(q)n(alk2)p- wherein m, n and p are independently 0 or 1, q is (i) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, or (ii), in the case where both m and p are 0, a divalent radical of formula —x2-q1- or -q1-x2— wherein x2 is —o—, s— or nra— wherein ra is hydrogen or optionally substituted c1-c3 alkyl, and q1 is an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, alk1 and alk2 independently represent optionally substituted divalent c3-c7 cycloalkyl radicals, or optionally substituted straight or branched, c1-c6 alkylene, c2-c6 alkenylene, or c2-c6 alkynylene radicals which may optionally contain or terminate in an ether (—o—), thioether (—s—) or amino (—nra—) link wherein ra is hydrogen or optionally substituted c1-c3 alkyl; x1 represents a bond; —c(═o); or —s(═o)2—; —nr4c(═o)—, —c(═o)nr4—, —nr4c(═o)nr5—, —nr4s(═o)2—, or —s(═o)2nr4— wherein r4 and r5 are independently hydrogen or optionally substituted c1-c6 alkyl; z is 0 or 1; a represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system wherein the radicals r1r2nh—y-l1-x1-[ch2]z— and honhco-[linker]- are attached different ring atoms; and -[linker]- represents a divalent linker radical linking a ring atom in a with the hydroxamic acid group coniioii, the length of the linker radical, from the terminal atom linked to the ring atom of a to the terminal atom linked to the hydroxamic acid group, is equivalent to that of an unbranched saturated hydrocarbon chain of from 3-10 carbon atoms.. .
06/12/14
20140163002
Cyclic p1 linkers as factor xia inhibitors
The present invention provides compounds of formula (ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor xia inhibitors or dual inhibitors of fxia and plasma kallikrein.


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Linker topics: Crosslinker, Binding Agent, Monovalent, Polypeptide, Crystallin, Lead Selenide, Lead Sulfide, Lead Telluride, Quantum Dot, Transparent Electrode, Refraction, Virtual Machine, Relaxation, Tertiary Amine, Acrylamide

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