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Ligase

Ligase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Compounds and methods for the targeted degradation of androgen receptor
Arvinas, Inc.
April 12, 2018 - N°20180099940

The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) androgen receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the e3 ubiquitin ligase and on the other end a moiety which binds androgen receptor, such that androgen receptor is placed in proximity to ...
Single nucleotide detection method
Base4 Innovation Ltd
March 22, 2018 - N°20180080074

A method of sequencing a nucleic acid such as dna or rna is provided. It is characterised by the steps of (1) generating a stream of single nucleoside triphosphates by progressive pyrophosphorolysis of the nucleic acid; (2) producing at least one substantially double-stranded oligonucleotide used probe by reacting in the presence of a polymerase and a ligase at least one of the ...
Method for blocking mirna
Hudsonalpha Institute For Biotechnology
March 15, 2018 - N°20180073066

A blocking nucleic acid for use in reducing the abundance of a non-target micro-rna (mirna) in an mirna library is provided, including: a single-stranded complementary region at one of the 5′ end of the blocking nucleic acid or the 3′ end of the blocking nucleic acid, that anneals with a binding region at a first end of the unwanted mirna; ...
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Single nucleotide detection method
Base4 Innovation Ltd
March 01, 2018 - N°20180057872

A method of sequencing a nucleic acid such as dna or rna is provided. It is characterised by the steps of (1) generating a stream of single nucleoside triphosphates by progressive pyrophosphorolysis of the nucleic acid; (2) producing at least one substantially double-stranded oligonucleotide used probe by reacting in the presence of a polymerase and a ligase at least one of the ...
Amplification and detection of ribonucleic acids
Applied Biosystem, Llc
February 22, 2018 - N°20180051328

Compositions, methods, and kits for detecting one or more species of rna molecules are disclosed. In one embodiment, a first adaptor and a second adaptor are ligated to the rna molecule using a polypeptide comprising double-strand specific rna ligase activity, without an intervening purification step. The ligated product is reverse transcribed, then at least some of the ribonucleosides in the ...
Derivatives of 1-[(cyclopentyl or 2-pyrrolidinyl)carbonylaminomethyl]-4-(1,3-thiazol-5-yl) benzene which are useful ...
University Of Dundee
February 22, 2018 - N°20180050021

There is provided novel small molecule e3 ubiquitin ligase protein binding ligand compounds, having utility in proteolysis targeted chimeras (protacs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided protacs which bind to a protein within the bromo- and extra-terminal (bet) family of proteins, and especially to protacs including novel small molecule e3 ...
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Nucleotide polymorphism detection method
Base4 Innovation Ltd
February 15, 2018 - N°20180044721

A method for characterising a dna analyte comprised of one or more polynucleotide types characteristic of a site of nucleotide polymorphism each of which includes a target region having the formula -x-y-z- wherein x and z are respectively first and second characteristic flanking oligonucleotide regions and y is one of the variants constituting the site is provided. The method is ...
Method of designing addressable array suitable for detection of nucleic acid sequence differences using ligase ...
Cornell Research Foundation, Inc.
January 04, 2018 - N°20180002744

The present invention is directed to a method of designing a plurality of capture oligonucleotide probes for use on a support to which complementary oligonucleotide probes will hybridize with little mismatch, where the plural capture oligonucleotide probes have melting temperatures within a narrow range. The present invention further relates to an oligonucleotide array comprising of a support with the plurality ...
Methods of constructing a circular template and detecting dna molecules
Personal Genomics, Inc.
January 04, 2018 - N°20180002731

A method of constructing a circular template includes preparing a partially double stranded linear dna molecule, and incubating the partially double stranded linear dna molecule with a ligase capable of intra-molecular ligation of single stranded dna molecules to generate a partially double stranded circular dna molecule. A method of detecting dna molecules includes the following steps. Target dna molecules are ...
Modulation of ube3a-ats expression
Ionis Pharmaceuticals, Inc.
December 21, 2017 - N°20170362592

Certain embodiments are directed to methods and compounds for inhibiting ube3a-ats, the endogenous antisense transcript of ubiquitin protein ligase e3a (ube3a). Such methods and compounds are useful for. Several embodiments provided herein relate to the discovery that antisense compounds targeting ube3a-ats induce paternal expression of ube3a. Several embodiments are drawn to methods and compounds for ...
Biotinylated and oxidized ldl receptor and advanced glycation end product receptor produced using genetically engineered ...
National Institute Of Agrobiological Sciences
December 14, 2017 - N°20170354129

The present invention pertains to a silkworm-type biotinylated ctld14 or srage and a method for manufacturing the same. One embodiment of the present invention provides a method for manufacturing biotinylated proteins, wherein the method includes a) a step for inserting a nucleic acid molecule for coding biotin ligase and protein in a coexpressable manner into a silkworm or a living ...
Pharmaceuticals and methods for treating hypoxia and screening methods therefor
Dana Farber Cancer Institute, Inc.
December 07, 2017 - N°20170350891

Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an ...
Strand displacement stop (sds) ligation
Lexogen Gmbh
November 30, 2017 - N°20170342409

A method of ligating dna molecules, wherein the dna molecules are in a hybrid with an rna molecule, including the steps of providing dna molecules that are in a rna:dna hybrid with an rna molecule, and ligating the dna molecules to each other with a double strand specific ligase
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Ubiquitin variant modulators of scf e3 ligases and their uses
The Governing Council Of The University Of Toronto
November 09, 2017 - N°20170321205

The invention provides ubiquitin variants that specifically bind to scf e3 ligases, and use of these variants to modulate the activity of scf e3 ligases.
Method for nucleic acid analysis directly from an unpurified biological sample
October 19, 2017 - N°20170298415

A method is provided for generating single-stranded dna circles from a biological sample. The method comprises the steps of: treating the biological sample with an extractant to release nucleic acids, thereby forming a sample mixture; neutralizing the extractant; denaturing the released nucleic acids to generate single-stranded nucleic acids; and contacting the single-stranded nucleic acids with a ligase that is capable ...
Thermostable blunt-end ligase and methods of use
October 19, 2017 - N°20170298338

Fusion proteins having thermostable blunt-end ligase activity are provided. Blunt-end ligases are useful for dna amplification, sequencing, production of recombinant dna and recombinant fusion proteins, and other purposes. These thermostable blunt-end dna ligases are useful in ligation schemes which include, e. G., an incubation at about 60-65° c. Or higher, or as high as about 94° c., or at ...
Method for breaking nucleic acid and adding adaptor by means of transposase, and reagent
Bgi Shenzhen Co., Limited
October 12, 2017 - N°20170292153

Provided are a method for breaking a nucleic acid and adding an adaptor by means of a transposase, and a reagent. The method comprises the following steps: conducting random breaking of a nucleic acid by using a transposase-embedded complex, wherein the transposase-embedded complex comprises a transposase and a first adaptor comprising a transposase identification sequence, and two ends of the ...
Chemically modified ligase cofactors, donors and acceptors
Trilink Biotechnologies, Inc.
September 28, 2017 - N°20170275672

Provided herein are methods for ligation of polynucleotides containing modified ligation components, particularly modified ligase cofactors, modified acceptors and modified donors. The methods readily applied to ligation-based assays for detection of a nucleic acid sequence where the use of the modified cofactor improves discrimination between matched and mismatched templates. Furthermore, the use of the modified ligation components reduces or eliminates ...
Ubiquitin variant modulators of hect e3 ligases and their uses
The Governing Council Of The University Of Toronto
September 28, 2017 - N°20170275341

The invention provides ubiquitin variants that specifically bind to hect e3 ligases, and methods of using these variants to modulate the activity of hect e3 ligases.
Dna-linked enzyme-coupled assays
The Regents Of The University Of California
August 24, 2017 - N°20170240952

Traditional enzyme characterization methods are low-throughput, and therefore limit engineering efforts in synthetic biology and biotechnology. Here we propose a dna-linked enzyme-coupled assay (dlenca) to monitor enzyme reactions in a high-throughput manner. Throughput is improved by removing the need for protein purification and by limiting the need for liquid chromatography mass spectrometry (lcms) product detection by linking enzymatic function to ...
Modified lipopolysaccharide glycoform and method of use
The Trustees Of Princeton University
August 24, 2017 - N°20170239350

The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of e. Coli to create mutant o-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.
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