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Leukocyte patents



      
           
This page is updated frequently with new Leukocyte-related patent applications. Subscribe to the Leukocyte RSS feed to automatically get the update: related Leukocyte RSS feeds. RSS updates for this page: Leukocyte RSS RSS


Date/App# patent app List of recent Leukocyte-related patents
02/26/15
20150056678
 Disease therapy using dying or dead cells patent thumbnailnew patent Disease therapy using dying or dead cells
A method of treating a disease characterized by a pathological immune response in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a cell preparation which comprises dying or dead leukocytes, the dying or dead leukocytes being capable of suppressing the pathological immune response, thereby treating the disease in the subject..
Enlivex Therapeutics Ltd.
02/26/15
20150056225
 Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof patent thumbnailnew patent Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof
The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a human leukocyte antigen (hla) class ii-related gene, which results in deficiency in mhc class ii expression and function. This invention also provides isolated cells further comprising a genetically engineered disruption in a beta-2 microglobulin (b2m) gene, which results in hla class i/class ii deficiency.
University Of Washington Through Its Center For Commercialization
02/19/15
20150051259
 Pro-inflammatory mediators in diagnosis and treatment of pulmonary disease patent thumbnailPro-inflammatory mediators in diagnosis and treatment of pulmonary disease
Treatment and diagnostic methods are provided for pulmonary disease, including chronic obstructive pulmonary disease. Various pro-inflammatory mediators are elevated in a model of copd that can be used predict the presence of copd and/or subtypes of copd in human patients.
National Jewish Health
02/19/15
20150051156
 Method of treating leukemia using rice prolamin patent thumbnailMethod of treating leukemia using rice prolamin
The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (pbmc) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells.
Mackay Memorial Hospital
02/12/15
20150044141
 Synthesis and application of novel imaging agents conjugated to dpa 713 analogs for imaging inflammation patent thumbnailSynthesis and application of novel imaging agents conjugated to dpa 713 analogs for imaging inflammation
The present invention provides analog compounds of dpa-713 which specifically bind the translocator protein (tspo), which is upregulated in activated leukocytes, some malignant tumors and tissues involved in steroid biogenesis. These compounds are linked via a linking moiety to a variety of imaging agents, including, for example, near infra-red dyes.
The Johns Hopkins University
02/05/15
20150037789
 Systemic genotoxicity as blood marker for allergic inflammation patent thumbnailSystemic genotoxicity as blood marker for allergic inflammation
The invention provides a method for detection of allergic inflammation in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of dna damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammation.
The Regents Of The University Of California
02/05/15
20150037346
 Prediction of responsiveness to treatment with immunomodulatory therapeutics and  monitoring abscopal effects during such treatment patent thumbnailPrediction of responsiveness to treatment with immunomodulatory therapeutics and monitoring abscopal effects during such treatment
Efficacy of a therapeutic to enhance antitumor immunity in a patient is predicted, where the therapeutic is one that targets an immunomodulatory leukocyte membrane protein (ilmp) to enhance immune activity. Peripheral blood sample from the patient is tested for levels of monocytes having specific cell surface markers (cd14+, hla-drlow) prior to treatment.
Sloan-kettering Institute For Cancer Research
01/29/15
20150030500
 Irradiation  inactivating pathogens and/or leukocytes in a biological fluid and process patent thumbnailIrradiation inactivating pathogens and/or leukocytes in a biological fluid and process
The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising: a casing (2), a support member (3) for carrying at least one irradiation bag (19) containing the biological fluid, a light source (4) comprising two banks of light (5, 6) disposed above and below the support member (3), and an agitating system (25) for moving the support member (3), the light source generating uvc light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to uvc.. .
Maco Pharma S.a.
01/22/15
20150023994
 Recombinant ganoderma lucidium immunomodulatory protein (rlz-8) and uses thereof patent thumbnailRecombinant ganoderma lucidium immunomodulatory protein (rlz-8) and uses thereof
Provided are the use of the recombinant ganoderma lucidum immunomodulatory protein (rlz-8) for the manufacturing of a medicament for antitumor, increasing leukocyte and inhibiting immunological rejection and the pharmaceutical composition comprising the rlz-8 protein, wherein the rlz-8 protein is expressed from pichia yeast.. .
01/15/15
20150017643
 Method of molecular typing patent thumbnailMethod of molecular typing
The invention relates to the identification of genetic traits in an individual. More specifically, the invention relates to identifying human leukocyte antigen (hla) alleles and haplotypes in a potential donor sample.
Nhs Blood & Transplant
01/08/15
20150010923

Method for labeling intracellular and extracellular targets of leukocytes


The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.. .
Beckman Coulter, Inc.
01/01/15
20150006086

Personal compatibility using hla


Processing personal compatibility matches includes a computer system receiving input of a first allele group determined to be present in a first person and a second allele group determined to be present in a second person. The first allele group and the second allele group are members of a set of allele groups for a human leukocyte antigen (hla) gene.
Instant Chemistry Inc.
01/01/15
20150005179

Hla primers for personal compatibility


Processing personal compatibility matches includes a computer system receiving input of a first allele group determined to be present in a first person and a second allele group determined to be present in a second person. The first allele group and the second allele group are members of a set of allele groups for a human leukocyte antigen (hla) gene.
Instant Chemistry Inc.
12/25/14
20140378479

Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta


Compounds that inhibit pi3kδ activity, including compounds that selectively inhibit pi3kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (pi3kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which pi3kδ plays a role in leukocyte function, using the compounds also are disclosed..
Icos Corporation
12/25/14
20140377777

Methods and compositions for diagnosis and prognosis of renal injury and renal failure


The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of insulin-like growth factor-binding protein 7, beta-2-glycoprotein 1, metalloproteinase inhibitor 2, alpha-1 antitrypsin, leukocyte elastase, serum amyloid p component, c-x-c motif chemokine 6, immunoglobulin a, immunoglobulin g subclass i, c-c motif chemokine 24, neutrophil collagenase, cathepsin d, c-x-c motif chemokine 13, involucrin, interleukin-6 receptor subunit beta, hepatocyte growth factor, cxcl-1, -2, -3, immunoglobulin g subclass ii, metalloproteinase inhibitor 4, c-c motif chemokine 18, matrilysin, c-x-c motif chemokine 11, and antileukoproteinase as diagnostic and prognostic biomarker assays of renal injury in the sepsis patient..
Astute Medical, Inc.
12/25/14
20140377742

Microfluidic device


Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations.
California Institute Of Technology
12/04/14
20140357840

Method for obtaining a dialyzable leukocyte extract


The present invention relates to a method for producing a transfer factor. The method comprises the following steps: freezing and thawing of peripheral-blood leukocytes, dialysis, tangential ultrafiltration, identification and quantification using high-resolution, molecular-exclusion liquid chromatography, and in vitro biological validation.
11/20/14
20140342375

Microfluidic processing of leukocytes for molecular diagnostic testing


Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas..
11/13/14
20140335149

Wound-healing promoting material


The object of the present invention is to provide a means for utilizing cells that have effects on wound healing as wound-healing promoting materials by efficiently concentrating such cells within a short period of time. The present invention provides a wound-healing promoting material which comprises a sheet-like porous body having on its surface at least leukocytes and/or platelets, a method for producing the same, a device for producing the same, and a method for treating wound sites using the same..
11/06/14
20140329809

New leukocyte infiltrate markers for rosacea and uses thereof


A process for the characterization of rosacea is disclosed. The process can include identifying for the first time new markers in leukocyte recruitment as well as the therapeutic applications targeting rosacea..
10/23/14
20140315242

Microfluidic chamber assembly for mastitis assay


The present invention relates to a device and method for the detection of mastitis or other disease from a body fluid of a mammal for example from cow's milk. The device and method relates to a wedge microfluidic chamber for using a minimal amount of fluid and being able to use the device to observe leukocytes in a mono-layer for the purpose of disease detection, cell counts or the like..
10/09/14
20140303026

Compounds for modulating integrin cd11b/cd18


The application describes an assay for the identification of small molecule modulators of integrin cd11b/cd18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (aids), myeloperoxidase deficiency, wiskott-aldrich syndrome, chronic granulomatous disease, hyper-igm syndromes, leukocyte adhesion deficiency, chediak-higashi syndrome, and severe combined immunodeficiency..
10/02/14
20140295550

Hla peptide therapy


The invention provides polypeptides derived from a major histocompatibility complex (mhc) class i human leukocyte antigen (hla), such as hla-a2, and derivatives or analogues thereof. The polypeptides, derivatives and analogues can be used to treat or prevent allosensitisation, such as the treatment or prevention of allograft rejection..
10/02/14
20140291227

Leukocyte filtration unit with reduced platelet adhesion


A filtration unit to selectively remove leukocytes from fluids containing platelets and systems including a filtration unit are provided. In one embodiment, a filtration unit is provided including an outer casing enclosing a porous element which includes a leukocyte-removal medium with a coating.
09/25/14
20140287985

Novel uses of elafin


The invention relates to novel uses of the polypeptide elafin, and/or homologues, derivatives or fragments thereof having inhibitory activity against leukocyte elastase for the prevention and treatment of medical conditions like sirs.. .
09/18/14
20140273018

Flow-through cell counting assay


A method for quantitatively measuring white blood cell (leukocyte) count and/or white blood cell (leukocyte) subsets count involves adding specific antibodies labeled with a marker to the biological fluid sample, capture of white blood cells from a fluid sample by a retainer, removal of other than leukocyte cells and other interfering substances by washing or using specific magnetic beads, and reading the result. The device for use in the present method includes a retainer for leukocyte cells and an absorption pad for taking up all excess washing solution flowing past the sample..
09/18/14
20140273000

Methods for analyzing blood to detect diseases associated with abnormal protein aggregation


A method of detecting a disease associated with abnormal protein aggregation in a subject is provided, the method comprising (a) contacting leukocytes from the subject with a probe that binds to pathogenic protein aggregates, and (b) detecting the probe bound to the pathogenic protein aggregates, wherein the presence of pathogenic protein aggregates in the leukocytes is indicative that the subject has a disease associated with abnormal protein aggregation. In one embodiment, the disease is alzheimer's disease or mild cognitive impairment..
09/18/14
20140272943

Rapid and highly fieldable viral diagnostic


The present invention relates to a rapid, highly fieldable, nearly reagentless diagnostic to identify active rna viral replication in a live, infected cells, and more particularly in leukocytes and tissue samples (including biopsies and nasal swabs) using an array of a plurality of vertically-aligned nanostructures that impale the cells and introduce a dna reporter construct that is expressed and amplified in the presence of active viral replication.. .
09/18/14
20140263070

Methods and systems for the filterless reduction of leukocytes in a biological fluid


Methods and systems for removing leukocytes from a biological fluid are disclosed. The methods and systems include a device that has a magnetic substrate coated with one or more polymeric materials that have an adhesion or adsorption affinity for leukocytes..
09/11/14
20140256565

Methods for hla typing


The present invention relates to methods for reducing the ambiguity in human leukocyte antigen (hla) allele identification. In particular, the methods comprise using target specific oligonucleotide (tso) techniques to determine a first set of possible hla alleles.
09/04/14
20140248289

Methods and compositions for the treatment of respiratory conditions via nkg2d inhibition


Methods and compositions for the treatment of respiratory conditions are provided. Aspects of the subject methods include administering to the subject a composition comprising an inhibitor of nkg2d-mediated activation of leukocytes.
08/14/14
20140227711

Genotoxicity as a biomarker for inflammation


The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of dna damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation.
08/14/14
20140227272

Anti-leukocyte adhesion for the mitigation of potential adverse events caused by cd3-specific binding domains


The present invention relates in essence to a compound which decreases or inhibits the binding of mammalian t-cells to mammalian endothelial cells for use in a method of prophylaxis and/or amelioration and/or treatment of clinical adverse events caused by therapy which comprises re-directing of t-cells against target cells in a patient. Methods of treatment of patients having or being at risk of clinical adverse events caused by therapy which comprises re-directing of t-cells against target cells are also contemplated..
08/07/14
20140220572

Method and system to detect, diagnose, and monitor the progression of alzheimer's disease


Various embodiments provide methods for the detection, the diagnosis, and/or the progression monitoring of alzheimer's disease by observing the epigenetic markers in leukocytes. Methods for determining a state of alzheimer's disease are provided.
07/31/14
20140212960

Leukocyte measurement device and reagent kit


A leukocyte measurement device is provided with a spread inspection window at a position separated from an opening part along a spreading direction of a blood-derived sample in a carrier, for making the carrier visible from outside. When the blood-derived sample is dropped from the opening part, leukocytes contained in the blood-derived sample are captured by the carrier in the vicinity of a dropping position, while erythrocytes and/or hemoglobin and the like spread through the carrier from the dropping position into a predetermined direction.
07/10/14
20140190888

Methods, systems and devices for separating tumor cells


Embodiments of the present disclosure are directed to the separation/capture of specific cells and/or contaminants, as well as the determination, monitoring, and treatment of cancer. Moreover, some embodiments are directed to methods, systems and devices for removing cancer, stem and/or tumor cells in vivo or in vitro from a bodily fluid to prevent or impede the proliferation of a cancer.
07/03/14
20140186345

Method of administering an antibody


Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin. Preferably, no more than about 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month..
06/26/14
20140179807

Module-level analysis of peripheral blood leukocyte transcriptional profiles


The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into clusters; iteratively selecting gene expression values for one or more transcriptional modules by: selecting for the module the genes from each cluster that match in every disease or condition; removing the selected genes from the analysis; and repeating the process of gene expression value selection for genes that cluster in a sub-fraction of the diseases or conditions; and iteratively repeating the generation of modules.. .
06/26/14
20140179659

Method for suppressing surgical site infection and column to be used for the method


An object of the present invention is to provide a method for suppressing surgical site infections (ssi) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject.
06/19/14
20140170169

Blocking antibody for transplantation


A method can include administering a donor-specific human leukocyte antigen antibody to a tissue transplant recipient where the antibody is an immunoglobulin g subclass 4 antibody (g4). Various other examples of devices, assemblies, systems, methods, etc., are also disclosed..
06/05/14
20140154772

Inhibitors of human phosphatidylinositol 3-kinase delta


Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (pi3kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which pi3kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit pi3kδ, while not significantly inhibiting activity of other pi3k isoforms.
05/29/14
20140147470

Methods of predicting host responsiveness to cancer immunotherapies by ex vivo induction of leukocyte-function-associated mrnas


Embodiments of the invention relate generally to ex vivo methods of quantifying expression of leukocyte-function associated mrnas and using the quantification to characterize an individual's potential responsiveness to cancer immunotherapy. Certain embodiments relate to methods to monitor the efficacy of ongoing cancer immunotherapy by evaluating expression of leukocyte-function associated mrnas genes before and administration of an anti-cancer immunotherapy regimen..


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Leukocyte topics: Leukocytes, Immunogenic, Stem Cells, Immune System, Animal Model, Human Leukocyte Antigen, Transgenic, Stimulator, Macrophage, Thromboxane, Attenuated, Fibronectin, Chronic Obstructive Pulmonary Disease, Antagonist, Vaccination

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This listing is a sample listing of patent applications related to Leukocyte for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Leukocyte with additional patents listed. Browse our RSS directory or Search for other possible listings.
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