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Leukocyte

Leukocyte-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods of human leukocyte antigen typing
Human Longevity, Inc.
November 30, 2017 - N°20170342479

Described herein are methods, systems, and media for hla typing an individual from nucleic acid or protein sequences. The methodology disclosed herein represents significant improvements over current methods of hla typing.
Inhibitors of human phosphatidylinositol 3-kinase delta
Icos Corporation
November 30, 2017 - N°20170340633

Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (pi3kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which pi3kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit pi3kδ, while not significantly inhibiting activity of other pi3k ...
Microfluidic processing of leukocytes for molecular diagnostic testing
Icos Corporation
November 23, 2017 - N°20170333900

Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.
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Blockade of tim-1 pathways and p-selectin pathways in treatment of neuroinflammatory degenerative disease
Leuvas Therapeutics
November 16, 2017 - N°20170328919

Methods for treating, preventing and reducing the progression of neurodegenerative and neurological diseases, including, without limitation alzheimer's disease, are provided. The methods of the invention inhibit one or both of tim-1 and p-selectin function and reduce leukocyte and platelet cell adhesion, activation and interaction with the vascular endothelium and infiltration of leukocytes into the brain.
Immune-compatible cells created by nuclease-mediated editing of genes encoding hla
Institute For Basic Science
November 16, 2017 - N°20170327795

The present invention relates to a method for producing immune-compatible cells or a cell population which comprises a step of editing one or two alleles of one or more immune-compatible antigen genes by gene deletion or modification in an isolated cell comprising at least one of the immune-compatible antigen genes selected from hla (human leukocyte antigen)-a, hla-b and hla-dr, ...
Anti-leukocyte adhesion for the mitigation of potential adverse events caused by cd3-specific binding domains
Amgen Research (munich) Gmbh
November 16, 2017 - N°20170327581

The present invention relates in essence to a compound which decreases or inhibits the binding of mammalian t-cells to mammalian endothelial cells for use in a method of prophylaxis and/or amelioration and/or treatment of clinical adverse events caused by therapy which comprises re-directing of t-cells against target cells in a patient. Methods of treatment of patients having or ...
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Compositions and methods for leukocyte differential counting
Immunicum Ab
November 02, 2017 - N°20170315060

The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify ...
Inhibitor of extracellular trap formation in leukocyte
Immunicum Ab
October 19, 2017 - N°20170296629

An object of the present invention is to provide a novel drug inhibiting extracellular trap formation in leukocytes. The present invention provides an inhibitor of extracellular trap formation in leukocytes containing a lactoferrin fragment, and a composition containing lactoferrin for treating a disease related to the extracellular trap formation in leukocytes.
Flexible biological fluid filters
Fenwal, Inc.
October 05, 2017 - N°20170282531

Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with a seal joining the walls of the housing, the filtration medium, and the support ...
Combination therapy for inducing immune response to disease
Ibc Pharmaceuticals, Inc.
October 05, 2017 - N°20170281767

The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for trop-2 (egp-1) and at least one binding site for cd3. The bispecific antibodies are of use for inducing an immune response against a trop-2 expressing tumor, such as carcinoma of the esophagus, pancreas, lung, stomach, colon, rectum, urinary bladder, breast, ovary, ...
Antigen delivery system
Sri International
October 05, 2017 - N°20170281752

A minimal antigen delivery system consists essentially of pegylated stealth liposomes loaded with an immunogenic human leukocyte antigen (hla) class restricted peptide and surface modified with a cell targeting peptide which mediates binding and internalization of the liposomes into a target cell.
Anti-himf antibodies to treat lung diseases
The Johns Hopkins University
September 28, 2017 - N°20170276688

Hypoxia induced mitogenic factor (himf) is a member of the “found in inflammatory zone” (fizz)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown. We identified bruton's tyrosine kinase (btk) as a functional himf binding partner ...
Methods and compositions for reducing antibiotic administration to farm animals
Advanced Animal Diagnotics, Inc.
September 28, 2017 - N°20170276663

The present invention provides a method of identifying an animal for which antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy is appropriate, comprising: a) collecting a sample from said animal; b) performing a leukocyte differential cell count on said sample; c) comparing said leukocyte differential cell count of (b) with ...
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Blocking pirb upregulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery ...
The Board Of Trustees Of The Leland Stanford Junior University
September 28, 2017 - N°20170274003

Targeting and disrupting paired-immunoglobulin-like receptor b (pirb) function increases synaptic connectivity and plasticity even after the critical period, and can enable significant structural and functional recovery from amblyopia. Provided are compositions comprising pirb, or lilrb2 (leukocyte immunoglobulin-like receptor 2) polypeptides for disrupting pirb/lilrb2 signaling, and methods of using the compositions for treating disorders associated with reduced synaptic plasticity including amblyopia.
Modulation of chrfam7a for anti-inflammatory therapies
The Regents Of The University Of California
September 21, 2017 - N°20170266222

The invention provides a pharmaceutical composition and methods of use thereof, for anti-inflammatory treatment, by altering expression and/or activity of chrfam7a, in leukocytes, as well as in epithelial cells.
Antagonism of the vip signaling pathway
Emory University
September 14, 2017 - N°20170258904

Inhibition of the vip signaling pathway with vip antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising administering a vip antagonist to a subject in combination with a cell. In certain embodiments, the subject is diagnosed with leukemia or lymphoma. In certain embodiments, the cell is a blood ...
Dpep-1 binding compositions and methods of use
Arch Biopartners, Inc.
September 14, 2017 - N°20170258872

Pharmaceutical compositions and methods of their use are provided for reducing inflammation in a subject, blocking leukocyte recruitment, inhibiting tumor metastasis, treating sepsis and preventing/reducing acute kidney injury.
Modulation of leukocyte activity in treatment of neuroinflammatory degenerative disease
Leuvas Therapeutics
September 07, 2017 - N°20170253657

Methods for treating and reducing the progression of neurodegenerative diseases, including, without limitation alzheimer's disease, are provided. The methods of the invention reduce or deplete neutrophil/myeloid cells in the region of the brain by blocking neutrophil/myeloid cell adhesion and interaction with the vascular endothelium, by blocking infiltration of neutrophil/myeloid cells into the brain, by reducing motility of ...
Leukocyte micrornas for use in diagnosis and treatment of endometriosis
University Of South Carolina
August 31, 2017 - N°20170247763

Methods for diagnosis and treatment of endornetriosis are described. Methods utilize the recognition that leukocyte mirnas can be dramatically dysregulated subjects suffering from endometriosis. Accordingly, leukocyte mirnas, as well as polynucleotides encoding the mirnas, can be utilized in the diagnosis and treatment of endometriosis.
Selective cytopheresis devices and related methods thereof
Cytopherx, Inc.
August 31, 2017 - N°20170246208

The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
Cancer vaccine composition
International Institute Of Cancer Immunology, Inc.
August 17, 2017 - N°20170232089

A cancer vaccine composition for human leukocyte antigen (hla)-a*0206-positive persons, comprising a protein product of the tumor suppressor gene wt1 or a partial peptide thereof.
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