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Leukocyte patents

      

This page is updated frequently with new Leukocyte-related patent applications.




 Integrated electrical profiling system for measuring leukocytes activation from whole blood patent thumbnailIntegrated electrical profiling system for measuring leukocytes activation from whole blood
A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.. .
Massachusetts Institute Of Technology


 Substituted aminopyrimidine compounds and methods of use patent thumbnailSubstituted aminopyrimidine compounds and methods of use
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the pi3k enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which pi3k enzymes play a role in leukocyte function, and hyperproliferative disorders associated with pi3k activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.


 Substituted aminopyrimidine compounds and methods of use patent thumbnailSubstituted aminopyrimidine compounds and methods of use
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the pi3k enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which pi3k enzymes play a role in leukocyte function, and hyperproliferative disorders associated with pi3k activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans..
Calitor Sciences, Llc


 T cell modulator patent thumbnailT cell modulator
Compositions, methods of use, and pharmaceutical preparations useful for modulation of immune responses are disclosed herein. In one embodiment a composition is extracted from immune organs or leukocytes derived from members of the chondrichthyes family through dialysis.

 Leukocyte removal filter material and leukocyte removal method patent thumbnailLeukocyte removal filter material and leukocyte removal method
Y≧−0.65×x+1.75   (1).. .

 Method for labeling intracellular and extracellular targets of leukocytes patent thumbnailMethod for labeling intracellular and extracellular targets of leukocytes
The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.. .
Beckman Coulter, Inc.


 Influenza-specific t-cell receptor and its uses in the detection, prevention and/or treatment of influenza patent thumbnailInfluenza-specific t-cell receptor and its uses in the detection, prevention and/or treatment of influenza
The present invention relates to specific t-cell receptor a-chains, t-cell receptor β-chains and t-cell receptors comprising said t-cell receptor a-chain and/or β-chain. In particular, the invention relates to t-cell receptors and/or chains binding to the influenza matrix peptide gilgfvftl (gl9 peptide) presented by human leukocyte antigen a2 (hla-a2) molecules.
Friedrich-alexander UniversitÄt Erlangen-nÜrnberg


 Compositions and methods to image and quantify inflammation patent thumbnailCompositions and methods to image and quantify inflammation
Compositions and methods for assessing inflammation in a subject. The present disclosure provides compositions for labeling leukocytes with a 19f-containing perfluoropolyether molecule ex vivo.
Celsense, Inc.


 Diagnosis and treatment of autoimmune diseases patent thumbnailDiagnosis and treatment of autoimmune diseases
The invention relates generally to the field of autoimmunity. More specifically, the invention relates to compositions and methods for the diagnosis, prevention, and treatment of human leukocyte antigen (hla)-associated autoimmune diseases, and in particular hla-b27-associated autoimmune diseases..
Newsouth Innovations Pty Limited


 Method for treating a blood component containing sample patent thumbnailMethod for treating a blood component containing sample
Provided is a treatment method for damaging an erythrocyte and a leukocyte while suppressing damage to cells other than blood cells present in blood. In an embodiment, the disclosure relates to a method for treating a sample containing blood components, the method including mixing a sample containing blood components with a surfactant a, where the surfactant a is a nonionic surfactant represented by general formula r1—o-(eo)n-r2 (i)..
Arkray, Inc.


Disease therapy by inducing immune response to trop-2 expressing cells

The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for trop-2 (egp-1) and at least one binding site for cd3. The bispecific antibodies are of use for inducing an immune response against a trop-2 expressing tumor, such as carcinoma of the esophagus, pancreas, lung, stomach, colon, rectum, urinary bladder, breast, ovary, uterus, kidney or prostate.
Ibc Pharmaceuticals, Inc.

Method for obtaining a cytokine-rich composition and composition obtained by means of this method

The invention relates to a method for preparing serums, said serums comprising cytokines and coagulation factors, and for preparing fibrin gel compositions, wherein the method comprises submitting an isolated biological sample comprising platelets and/or leukocytes to different steps of different gravity force to obtain supernatants with high concentrations of cytokines and coagulation factors. The invention also encompasses serums obtainable by this method, and other derived products comprising them.
Nte-sener Healthcare, S.a.

Mass spectrometric diagnosis of sepsis without blood culture

The invention relates to methods and instruments for the rapid detection and rapid mass spectrometric identification of microbial infective agents in blood or other body fluids. The invention recognizes that blood is not a good environment for the cultivation of microbes and provides a method which (a) largely destroys or dissolves the human particles in body fluids, such as erythrocytes and leukocytes in blood, without impairing the ability of the microbes to reproduce, (b) separates the microbial pathogens from the fluid, (c) cultivates them in a nutrient broth which contains none of the antimicrobial components of the body fluids, (d) separates them from the nutrient broth, and (e) identifies the microbes by a mass spectrum of the microbial proteins.

Compositions and methods to image and quantify inflammation

Compositions and methods for assessing inflammation in a subject. The preset disclosure provides compositions for labeling leukocytes with a 19f-containing perfluoropolyether molecule ex vivo.
Celsense, Inc.

Molecular imaging methods for diagnosis and evaluation of ocular and systemic diseases

This invention relates generally to minimally-invasive, in vivo methods of detecting one or more ligands on an intraluminal surface of a blood vessel using microparticles coated with one or more ligand binding partners. More particularly, in certain embodiments, the invention relates to minimally-invasive, in vivo methods of detecting endothelial and leukocyte antigens that are predictive of diabetic retinopathy (dr) and/or other conditions using protein-conjugated microparticles detectable by a non-invasive detection system, for example, a scanning laser ophthalmoscope.
Massachusetts Eye And Ear Infirmary

Plif multimeric peptides and uses thereof

Provided is a multimeric peptide comprising at least two peptide monomers linked to one another, each of the at least two peptide monomers comprising at least 6 consecutive amino acids from the amino acid sequence as set forth in seq id no: 1, wherein the at least two peptide monomers are each no longer than 30 amino acids, wherein the multimeric peptide is capable of reducing binding of placenta immunomodulatory factor (plif) to human leukocytes.. .
Ramot At Tel-aviv University Ltd.

Agents for the molecular imaging of serine-protease in human pathologies

The present invention is directed to the use of an irreversible ligand of a serine protease selected from the group consisting of leukocyte elastase, thrombin, tissue plasminogen activator (t-pa) and plasmin for the molecular imaging of said serine protease and the diagnosis of pathophysiological conditions associated with said serine protease activity.. .
Universite Paris Diderot - Paris 7

Acellular pro-inflammatory compositions, process for making same and methods of using same

This invention relates to acellular-based therapies for decreasing the level of regulatory t cells (treg) and/or increasing the level of pro-inflammatory t cells (th17) to favor immune stimulation. To provide these therapeutic effects, an allogeneic leukocyte population is contacted with another leukocyte population and the acellular components produced are isolated.
Canadian Blood Services

Blood analysis method, control device, and blood cell analyzer

The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or hgb measurement.
Shenzhen Mindray Bio-medical Electronics Co., Ltd.

Leukocyte esterase detection from throat swab

The present invention relates to the field of infectious diseases. The invention specifically relates to the diagnostic test for acute bacterial pharyngitis.

Methods for inducing the differentiation of blood monocytes into functional dendritic cells

Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood and produce a leukocyte concentrate comprising monocytes and plasma containing proteins.
Yale University

Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors

The hiv-specific cytotoxic t lymphocyte (ctl) response is a critical component in controlling hiv replication and is an important part of the ultimate failure to eradicate the virus. Disclosed herein are methods for genetically enhancing the hiv-specific ctl response to allow long-term viral suppression or viral clearance.
The Regents Of The University Of California

Method to functionalize cells in human blood, other fluids and tissues using nanoparticles

Compositions and methods for inhibiting metastatic cancer cells. The compositions comprise nanoparticles which have incorporated therein leukocyte adhesion molecules and therapeutic molecules exposed on their surface.

Allogeneic tumor cell vaccination

The present invention relates to cancer immunotherapy, specifically to allogeneic tumor cell vaccines. According to some embodiments, the invention provides novel cell lines useful as therapeutic cell vaccine compositions.

High efficiency microfluidic purification of stem cells to improve transplants

Described herein is a novel, highly efficient system to remove erythrocytes and purify leukocytes would raise the quality of ucb and other transplant grafts, thereby significantly improving patient outcomes.. .
The Trustees Of Princeton University

Reducing the immunogenicity of allografts

(c) isolating the passenger leukocytes from the recirculating perfusion solution to prevent the passenger leukocytes from re-entering the tissue or organ.. .

Receptors for b7-h4

Isolated cell surface receptors for b7-h4 have been identified based on function. B7-h4 receptor activation by b7-h4 on the dendritic cell, t follicular helper cell and germinal center b cell membrane stimulates inhibitory signaling in those leukocytes.
Amplimmune, Inc.

Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same

The present invention provides novel antibodies specifically bind to an epitope on cd43 and cea expressed on nonhematopoietic cancer cells, but do not specifically bind to a cd43 expressed by a leukocyte or by a jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a lea structure, a lea-lactose structure, a lndfh ii structure, or a lnt structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes..
Bioalliance C.v.

Methods and devices for high throughput purification

Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes..
University Of Maryland, Baltimore

Microfluidic device

Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations.
California Institute Of Technology



Leukocyte topics:
  • Leukocytes
  • Immunogenic
  • Stem Cells
  • Immune System
  • Animal Model
  • Human Leukocyte Antigen
  • Transgenic
  • Stimulator
  • Macrophage
  • Thromboxane
  • Attenuated
  • Fibronectin
  • Chronic Obstructive Pulmonary Disease
  • Antagonist
  • Vaccination


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    This listing is a sample listing of patent applications related to Leukocyte for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Leukocyte with additional patents listed. Browse our RSS directory or Search for other possible listings.


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