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Leukocyte

Leukocyte-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Disease therapy by inducing immune response to trop-2 expressing cells
Ibc Pharmaceuticals, Inc.
August 10, 2017 - N°20170226219

The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for trop-2 (egp-1) and at least one binding site for cd3. The bispecific antibodies are of use for inducing an immune response against a trop-2 expressing tumor, such as carcinoma of the esophagus, pancreas, lung, stomach, colon, rectum, urinary bladder, breast, ovary, ...
Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer
Monash University
August 10, 2017 - N°20170224731

The present invention generally relates to methods of preparing leukocytes, particularly t cells, ex vivo for use in immunotherapy, particularly cancer immunotherapy. More specifically, the invention relates to methods for the preparation of leukocytes exhibiting cytotoxic properties for use in adoptive cell transfer. The invention also relates to cells and compositions including them for cancer immunotherapy. The invention also relates ...
Stabilization of whole blood samples
The General Hospital Corporation
August 10, 2017 - N°20170223949

Methods for stabilizing blood samples, e. G., clinical blood samples, for storage or transportation before use. Exemplary applications include but are not limited to enrichment of leukocyte subtypes such as t-cells or neutrophils for cytokine and immuno-assays; isolation of progenitor cells from cord blood or peripheral blood for transplantation; isolation of fetal cells from the maternal blood for diagnosis; and ...
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Use of hla genetic status to assess or select treatment of celiac disease
Immusant, Inc.
August 03, 2017 - N°20170218453

Provided herein are methods of adjusting or selecting a gluten peptide therapy based on the human leukocyte antigen (hla) genotype, in particular hla-dq2. 5 homozygosity, of a subject having or suspected of having celiac disease. Also provided herein are methods of identifying (e. G., diagnosing) a subject, such as a subject having or suspected of having celiac disease and/or assessing ...
Clinically useful non-antigen pulsed dendritic cells
Batu Biologics, Inc.
August 03, 2017 - N°20170216354

Disclosed are compositions, methods of use, and pharmaceutical preparations useful for treatment of cancer. In one embodiment dendritic cells (dc) are generated from a patient in need of treatment, matured utilizing a leukocyte lysate, and readministered into the same patient without the use of antigen pulsing. Dc from different tissues, different stages of maturation, and different methods of inducing dc ...
Method for diagnosing mastitis in a lactating animal
Mastatix, Ltd.
July 27, 2017 - N°20170208769

The invention relates to a method for diagnosing mastitis in a lactating and preferably bovine animal, the method comprising recording data, the data having been obtained from analyzing a series of milk samples, the series of milk samples in turn having been obtained by periodically milking an animal, the data including total and/or differential leukocyte counts and changes in ...
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Genetic markers for memory loss
University Of Rochester
June 29, 2017 - N°20170183733

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from peripheral blood leukocytes taken from the subject and comparing the value of the subject's gene expression profile with the value of a normal gene expression profile. A change in the value ...
Igg subtyping assay for identifying transplantable tissue samples
Nj Sharing Network
June 08, 2017 - N°20170160278

The disclosure relates to methods for assessing the suitability of a tissue obtained from a vertebrate (e. G., human) donor for grafting to a recipient, such as another vertebrate of the same species. The method involves contacting leukocytes obtained from the donor with serum from the recipient. Binding between recipient antibodies and the leukocytes is assessed, specifically focusing on the ...
Erythrocyte aggregation and leukocyte isolation
General Electric Company
June 01, 2017 - N°20170153223

A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation ...
Microfluidic device
California Institute Of Technology
May 18, 2017 - N°20170136463

Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from ...
Flexible biological fluid filters
Fenwal, Inc.
May 18, 2017 - N°20170136167

Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with a seal joining the walls of the housing, the filtration medium, and the support ...
Humanized mouse models and uses thereof
Champions Biotechnology, Inc
May 04, 2017 - N°20170118965

The invention relates generally to a humanized mouse model and uses thereof. Specifically, the invention relates to methods for generating, maintaining, and expanding a culture of leukocytes in heterologous animals. This invention also relates to use of these animals as models of human immune system for testing molecules in order to treat a disease or disorder such as cancer.
Anti-histone therapy for vascular necrosis in severe glomerulonephritis
Immunomedics, Inc.
April 27, 2017 - N°20170114126

Severe glomerulonephritis involves cell necrosis as well as netosis, programmed neutrophil death leading to expulsion of nuclear chromatin and neutrophil extracellular traps (nets). Histones released by neutrophils undergoing netosis killed glomerular endothelial cells, podocytes, and parietal epithelial cells. This was prevented by histone-neutralizing agents anti-histone igg, activated protein c and heparin. Histone toxicity on glomeruli was tlr2/4-dependent. Anti-gbm glomerulonephritis ...
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Zwitterionic-bias material for blood cell selection and application thereof
Chung Yuan Christian University
April 06, 2017 - N°20170096637

The invention provides a zwitterionic-bias material for blood cell selection and a method for removing leukocytes from a blood sample. The zwitterionic-bias material for blood cell selection is a copolymer formed by zwitterionic structural units and charged structural units wherein the zwitterionic structural unit comprises at least one positively charged moiety and one negatively charged moiety, a distance between the ...
Detection of shed cd31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling ...
Institut National De La Sante Et De La Recherche Medicale (inserm)
March 16, 2017 - N°20170074891

The present invention stems from the finding that the extracellular domain of cd31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of cd31. A method for detecting shed cd31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as cd31 and ...
Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
New Health Sciences, Inc.
March 16, 2017 - N°20170072339

A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/...
Peptides that block leukocyte recruitment and methods of use
Arch Cancer Therapeutics, Inc.
March 16, 2017 - N°20170072006

Disclosed are novel peptides comprising seq id no: 1 and modifications thereof, which are effective in blocking leukocyte recruitment. The disclosed peptides are useful for treating diseases associated with leukocyte recruitment for example inhibiting metastasis of a solid tumor to the liver and lungs and for treating sepsis. Also disclosed are methods of screening for compounds having the ability to block ...
Pharmaceutical composition comprising an anti-cd6 monoclonal antibody used in the diagnosis and treatment of rheumatoid ...
Centro De Inmunologia Molecular
March 09, 2017 - N°20170066835

The present invention is related to the branch of immunology and particularly with the generation of pharmaceutical compositions containing a humanized monoclonal antibody recognizing the leukocyte differentiation antigen cd6. Accordingly with that statement, the purpose of this invention is to provide pharmaceutical compositions which contain a humanized anti-monoclonal antibody for the diagnosis and treatment of autoimmune diseases, particularly the rheumatoid ...
Metabolic and genetic biomarkers for memory loss
University Of Rochester
February 23, 2017 - N°20170052204

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and also analyzing the gene expression profile from leukocytes and comparing the value of the subject's biomarker profile (lipidomic ...
Method and device for conserving viable and functional human polymorphonuclear neutrophils
Institut National De La Sante Et De La Recherche Medicale (inserm)
February 23, 2017 - N°20170051253

A method for keeping leukocytes alive ex vivo or in vitro, comprising maintaining the leukocytes in a medium comprising from 3 to 10 mm of glucose, in hypoxic conditions with p(02)≦10 mm hg.
Inhibitors of human phosphatidylinositol 3-kinase delta
Icos Corporation
February 23, 2017 - N°20170049772

Methods of inhibiting phosphotidylinositol 3-kinase delta isoform (pi3kδ) activity, and methods of treating disease, such as disorders of immunity and inflammation, in which pi3kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit pi3kδ, while not significantly inhibiting activity of other pi3k ...
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