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Leukocyte

Leukocyte-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Flexible biological fluid filters
Fenwal, Inc.
October 05, 2017 - N°20170282531

Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with a seal joining the walls of the housing, the filtration medium, and the support ...
Combination therapy for inducing immune response to disease
Ibc Pharmaceuticals, Inc.
October 05, 2017 - N°20170281767

The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for trop-2 (egp-1) and at least one binding site for cd3. The bispecific antibodies are of use for inducing an immune response against a trop-2 expressing tumor, such as carcinoma of the esophagus, pancreas, lung, stomach, colon, rectum, urinary bladder, breast, ovary, ...
Antigen delivery system
Sri International
October 05, 2017 - N°20170281752

A minimal antigen delivery system consists essentially of pegylated stealth liposomes loaded with an immunogenic human leukocyte antigen (hla) class restricted peptide and surface modified with a cell targeting peptide which mediates binding and internalization of the liposomes into a target cell.
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Methods and compositions for reducing antibiotic administration to farm animals
Advanced Animal Diagnotics, Inc.
September 28, 2017 - N°20170276663

The present invention provides a method of identifying an animal for which antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy is appropriate, comprising: a) collecting a sample from said animal; b) performing a leukocyte differential cell count on said sample; c) comparing said leukocyte differential cell count of (b) with ...
Combination therapy with t-cell redirecting bispecific antibodies and checkpoint inhibitors
Ibc Pharmaceuticals, Inc.
September 28, 2017 - N°20170275375

The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for a tumor-associated antigen (taa) and at least one binding site for an antigen expressed on an effector t cell, nk cell, monocyte or neutrophil. The bispecific antibodies are of use for inducing an immune response against a taa-expressing tumor. The methods ...
Blocking pirb upregulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery ...
The Board Of Trustees Of The Leland Stanford Junior University
September 28, 2017 - N°20170274003

Targeting and disrupting paired-immunoglobulin-like receptor b (pirb) function increases synaptic connectivity and plasticity even after the critical period, and can enable significant structural and functional recovery from amblyopia. Provided are compositions comprising pirb, or lilrb2 (leukocyte immunoglobulin-like receptor 2) polypeptides for disrupting pirb/lilrb2 signaling, and methods of using the compositions for treating disorders associated with reduced synaptic plasticity including amblyopia.
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Antagonism of the vip signaling pathway
Emory University
September 14, 2017 - N°20170258904

Inhibition of the vip signaling pathway with vip antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising administering a vip antagonist to a subject in combination with a cell. In certain embodiments, the subject is diagnosed with leukemia or lymphoma. In certain embodiments, the cell is a blood ...
Dpep-1 binding compositions and methods of use
Arch Biopartners, Inc.
September 14, 2017 - N°20170258872

Pharmaceutical compositions and methods of their use are provided for reducing inflammation in a subject, blocking leukocyte recruitment, inhibiting tumor metastasis, treating sepsis and preventing/reducing acute kidney injury.
Modulation of leukocyte activity in treatment of neuroinflammatory degenerative disease
Leuvas Therapeutics
September 07, 2017 - N°20170253657

Methods for treating and reducing the progression of neurodegenerative diseases, including, without limitation alzheimer's disease, are provided. The methods of the invention reduce or deplete neutrophil/myeloid cells in the region of the brain by blocking neutrophil/myeloid cell adhesion and interaction with the vascular endothelium, by blocking infiltration of neutrophil/myeloid cells into the brain, by reducing motility of ...
Leukocyte micrornas for use in diagnosis and treatment of endometriosis
University Of South Carolina
August 31, 2017 - N°20170247763

Methods for diagnosis and treatment of endornetriosis are described. Methods utilize the recognition that leukocyte mirnas can be dramatically dysregulated subjects suffering from endometriosis. Accordingly, leukocyte mirnas, as well as polynucleotides encoding the mirnas, can be utilized in the diagnosis and treatment of endometriosis.
Selective cytopheresis devices and related methods thereof
Cytopherx, Inc.
August 31, 2017 - N°20170246208

The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
Cancer vaccine composition
International Institute Of Cancer Immunology, Inc.
August 17, 2017 - N°20170232089

A cancer vaccine composition for human leukocyte antigen (hla)-a*0206-positive persons, comprising a protein product of the tumor suppressor gene wt1 or a partial peptide thereof.
Disease therapy by inducing immune response to trop-2 expressing cells
Ibc Pharmaceuticals, Inc.
August 10, 2017 - N°20170226219

The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for trop-2 (egp-1) and at least one binding site for cd3. The bispecific antibodies are of use for inducing an immune response against a trop-2 expressing tumor, such as carcinoma of the esophagus, pancreas, lung, stomach, colon, rectum, urinary bladder, breast, ovary, ...
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Stabilization of whole blood samples
The General Hospital Corporation
August 10, 2017 - N°20170223949

Methods for stabilizing blood samples, e. G., clinical blood samples, for storage or transportation before use. Exemplary applications include but are not limited to enrichment of leukocyte subtypes such as t-cells or neutrophils for cytokine and immuno-assays; isolation of progenitor cells from cord blood or peripheral blood for transplantation; isolation of fetal cells from the maternal blood for diagnosis; and ...
Method and device for quality controlling a blood-based product
Celltool Gmbh
August 03, 2017 - N°20170219568

A method and device for quality controlling a blood-based product. In order to control the quality of a blood-based product which comprises an erythrocyte concentrate, a thrombocyte concentrate, a granulocyte concentrate, a leukocyte concentrate, whole blood and/or blood plasma, a raman spectrum is recorded. By means of evaluating the raman spectrum, it is determined whether the blood-based product can ...
Use of hla genetic status to assess or select treatment of celiac disease
Immusant, Inc.
August 03, 2017 - N°20170218453

Provided herein are methods of adjusting or selecting a gluten peptide therapy based on the human leukocyte antigen (hla) genotype, in particular hla-dq2. 5 homozygosity, of a subject having or suspected of having celiac disease. Also provided herein are methods of identifying (e. G., diagnosing) a subject, such as a subject having or suspected of having celiac disease and/or assessing ...
Clinically useful non-antigen pulsed dendritic cells
Batu Biologics, Inc.
August 03, 2017 - N°20170216354

Disclosed are compositions, methods of use, and pharmaceutical preparations useful for treatment of cancer. In one embodiment dendritic cells (dc) are generated from a patient in need of treatment, matured utilizing a leukocyte lysate, and readministered into the same patient without the use of antigen pulsing. Dc from different tissues, different stages of maturation, and different methods of inducing dc ...
Method for diagnosing mastitis in a lactating animal
Mastatix, Ltd.
July 27, 2017 - N°20170208769

The invention relates to a method for diagnosing mastitis in a lactating and preferably bovine animal, the method comprising recording data, the data having been obtained from analyzing a series of milk samples, the series of milk samples in turn having been obtained by periodically milking an animal, the data including total and/or differential leukocyte counts and changes in ...
Use of leukocytes and novel biomarkers in the diagnosis, confirmation, and treatment of a neurological ...
La Jolla Institute For Allergy & Immunology
June 29, 2017 - N°20170184612

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether pd has progressed in a subject afflicted with pd, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of ...
Genetic markers for memory loss
University Of Rochester
June 29, 2017 - N°20170183733

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from peripheral blood leukocytes taken from the subject and comparing the value of the subject's gene expression profile with the value of a normal gene expression profile. A change in the value ...
Igg subtyping assay for identifying transplantable tissue samples
Nj Sharing Network
June 08, 2017 - N°20170160278

The disclosure relates to methods for assessing the suitability of a tissue obtained from a vertebrate (e. G., human) donor for grafting to a recipient, such as another vertebrate of the same species. The method involves contacting leukocytes obtained from the donor with serum from the recipient. Binding between recipient antibodies and the leukocytes is assessed, specifically focusing on the ...
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