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Leukocyte

Leukocyte-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Leukocyte quantitation microfluidic method and device
Kennesaw State University Research And Service Foundation, Inc.
May 10, 2018 - N°20180128728

A microfluidic solenoid point of use device for discrete quantitation of magnetized cells. The inventive device provides higher accuracy, lower cost, and less bulk than other counting devices.
Pure platelet-rich plasma (p-prp) composition for treatment of subclinical mastitis and methods of producing and ...
Universidad De Caldas
May 10, 2018 - N°20180125893

A pure platelet-rich plasma (p-prp) composition as an alternative to conventional antibiotic treatment of subclinical mastitis caused by gram-positive bacteria in bovine including five live platelets and leukocytes, an anticoagulant, and an activating substance.
Methods, reagents and kits for flow cytometric immunophenotyping
Erasmus University Medical Center Rotterdam
May 03, 2018 - N°20180120301

The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization ...
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Standard cell suspension
Hitachi Chemical Company, Ltd.
April 05, 2018 - N°20180095086

The present invention relates to a standard cell suspension for confirming the stainability of a treatment solution that differentially stains circulating tumor cells (ctcs) and leucocytes, containing (a) a cell line having an antigen that is specific for human cancer cells and (b) a cell line having an antigen that is specific for human leukocytes, wherein the (a) and (b) ...
Hla-restricted epitopes encoded by somatically mutated genes
The Johns Hopkins University
March 29, 2018 - N°20180086832

Mutant epitopes encoded by cancer genes are virtually always located in the interior of cells, making them invisible to conventional antibodies. We generated single chain variable fragments (scfvs) specific for mutant peptides presented on the cell surface by human leukocyte antigen (hla) molecules. These scfvs can be converted to full-length antibodies, termed manabodies, targeting “mutation associated neo-antigensȁ...
Systems and methods for deriving and collecting platelet products
Fenwal, Inc.
March 22, 2018 - N°20180078582

Systems and methods are provided for deriving a platelet product from a plurality of buffy coats. A plurality of buffy coats are separately collected, for example, using a conventional floor centrifuge. Plasma and/or a platelet additive solution may be added to the buffy coats. The buffy coats are pooled into a container and conveyed into a centrifuge or are ...
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Functional immunophenotyping of leukocytes in human tissues
The Regents Of The University Of California
March 01, 2018 - N°20180055882

Methods of detecting surface markers on t-cells from skin samples are provided. T-cells can be isolated from skin samples for example using single density centrifugation. The percentage of cd8+ cells being ctla4+pd-1+ can be used to predict responsiveness to anti-pd-1 therapy.
Anti cd4 antibodies to prevent in particular graft -versus - host - disease (gvhd)
Fraunhofer-gesellschaft Zur Förderung Der Angewandten Forschung E.v.
February 22, 2018 - N°20180051254

The present invention relates to, among others, an in vitro method of modifying a cell graft containing immune cells comprising the steps of incubating a cell graft containing immune cells with an anti cd4 antibody wherein said incubating is carried out for from 1 minute to 7 days, b) removing unbound antibody from said graft; as well as to corresponding modified grafts ...
Molecular characterization of circulating tumor cells
Menarini Silicon Biosystems, Inc.
February 15, 2018 - N°20180045712

The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that ...
Leukocyte esterase detection from throat swab
February 15, 2018 - N°20180044713

The present invention relates to the field of infectious diseases. The invention specifically relates to the diagnostic test for acute bacterial pharyngitis. The test is used in screening for group a beta haemolytic streptococcus by the identifying the presence of leukocyte esterase in the throat. The leukocyte esterase throat swab test is compared to the rapid step test for efficiency ...
Anti cd4 antibodies to prevent in particular graft -versus - host - disease (gvhd)
Fraunhofer-gesellschaft Zur Forderung Der Angewandten Forschung E.v.
February 01, 2018 - N°20180030414

The present invention relates to, among others, an in vitro method of modifying a cell graft containing immune cells comprising the steps of incubating a cell graft containing immune cells with an anti cd4 antibody wherein said incubating is carried out for from 1 minute to 7 days, b) removing unbound antibody from said graft; as well as to corresponding modified grafts ...
Methods of regulating uptake and transcellular transport of leukocytes and therapeutics
University Of Maryland, College Park
January 25, 2018 - N°20180021414

Methods for controlling and regulating engulfment, uptake and/or transcellular transport at a stage following initial engagement of an agent to the endothelium are provided, based on the identification of cam-mediated endocytosis and the sphingomyelin/ceramide pathway as active steps in transcellular tem. Administration of regulators relating to the identified pathways, such as nhe1, sphingomyelinases, acid sphingomyelinase and ceramide, permit ...
Reagents, methods and kits for diagnosing primary immunodeficiencies
Erasmus University Medical Center Rotterdam
January 18, 2018 - N°20180017560

This invention relates to the field of primary immunodeficiencies (pid), more specifically to means and method for the diagnosis of pid of the lymphoid system. Provided are unique reagent compositions for the flow cytometric immunophenotyping of leukocytes comprising fluorochrome-conjugated antibodies directed against various specific combinations of markers. Also provided are kits comprising the reagent compositions, and methods using the same.
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Diagnosis of leukocyte-mediated disease and halogen gas exposure
Saint Louis University
January 04, 2018 - N°20180003726

Described are glutathione adducts of fatty aldehydes (fald-gsh) and methods useful in the detection of fald-gsh in the identification of pathologies associated with leukocyte-mediated disease conditions, including eosinophil and neutrophil activation. Thus, the present disclosure provides methods of diagnosing a subject as having or being at risk of developing a leukocyte-mediated disease (lmd) comprising (a) detecting the level of glutathione ...
Method and material for separating leukocytes or mononuclear cells
Kaneka Corporation
January 04, 2018 - N°20180002663

An object of the present invention is to provide a separation system and a separation material for efficiently separating white blood cells or mononuclear cells from a biological fluid containing blood cell components. White blood cells or mononuclear cells can be efficiently separated by contacting a biological fluid containing blood cell components with a separation material having an average fiber ...
Removal of immunoglobulins and leukocytes from biological fluids
Pall Corporation
December 28, 2017 - N°20170368477

Devices, systems, and methods for depleting fluids of immunoglobulins and leukocytes are disclosed.
Traditional chinese medicine combination for regulating immune function and preparation method therefor
Jiangzhong Pharmaceutical Co., Ltd.
December 28, 2017 - N°20170368121

The present invention relates to a traditional chinese medicine composition for regulating immunity and preparation method thereof, characterized in that the composition comprises raw materials such as radix panacis quinquefolii, ganoderma, fermented cordyceps sinensis powder, flos rosae rugosae, and rhizoma anemarrhenae and is prepared into various conventional pharmaceutical formulations through processes such as pulverization, water decoction and alcohol extraction. The ...
Methods of treating and prognosing nonhematopoietic malignant tumors
Memorial Sloan Kettering Cancer Center
December 21, 2017 - N°20170363635

Provided herein are methods of treating a nonhematopoietic malignant tumor in a patient and methods of prognosing a nonhematopoietic malignant tumor in a patient, comprising administering to the patient a therapeutically effective amount of an agent that preferentially kills or inhibits proliferation or activity of leukocytes relative to nonhematopoietic cells.
Blood filter and method of manufacturing the same
Kolon Industries, Inc.
December 14, 2017 - N°20170354774

Disclosed are a blood filter which exhibits excellent leukocyte elimination performance as well as significantly improved blood throughput per unit time and erythrocyte recovery rate and a method of manufacturing the same. The blood filter of the present invention includes a pre-treatment filter which is a laminate of first non-woven fabrics having a mean fiber diameter of 5 to 30 μ...
Methods of human leukocyte antigen typing
Human Longevity, Inc.
November 30, 2017 - N°20170342479

Described herein are methods, systems, and media for hla typing an individual from nucleic acid or protein sequences. The methodology disclosed herein represents significant improvements over current methods of hla typing.
Inhibitors of human phosphatidylinositol 3-kinase delta
Icos Corporation
November 30, 2017 - N°20170340633

Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (pi3kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which pi3kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit pi3kδ, while not significantly inhibiting activity of other pi3k ...
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