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Leukocyte patents



      
           
This page is updated frequently with new Leukocyte-related patent applications. Subscribe to the Leukocyte RSS feed to automatically get the update: related Leukocyte RSS feeds. RSS updates for this page: Leukocyte RSS RSS


Leukocyte filtration unit with reduced platelet adhesion

Leukocyte filtration unit with reduced platelet adhesion

Date/App# patent app List of recent Leukocyte-related patents
10/09/14
20140303026
 Compounds for modulating integrin cd11b/cd18 patent thumbnailCompounds for modulating integrin cd11b/cd18
The application describes an assay for the identification of small molecule modulators of integrin cd11b/cd18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (aids), myeloperoxidase deficiency, wiskott-aldrich syndrome, chronic granulomatous disease, hyper-igm syndromes, leukocyte adhesion deficiency, chediak-higashi syndrome, and severe combined immunodeficiency..
10/02/14
20140295550
 Hla peptide therapy patent thumbnailHla peptide therapy
The invention provides polypeptides derived from a major histocompatibility complex (mhc) class i human leukocyte antigen (hla), such as hla-a2, and derivatives or analogues thereof. The polypeptides, derivatives and analogues can be used to treat or prevent allosensitisation, such as the treatment or prevention of allograft rejection..
10/02/14
20140291227
 Leukocyte filtration unit with reduced platelet adhesion patent thumbnailLeukocyte filtration unit with reduced platelet adhesion
A filtration unit to selectively remove leukocytes from fluids containing platelets and systems including a filtration unit are provided. In one embodiment, a filtration unit is provided including an outer casing enclosing a porous element which includes a leukocyte-removal medium with a coating.
09/25/14
20140287985
 Novel uses of elafin patent thumbnailNovel uses of elafin
The invention relates to novel uses of the polypeptide elafin, and/or homologues, derivatives or fragments thereof having inhibitory activity against leukocyte elastase for the prevention and treatment of medical conditions like sirs.. .
09/18/14
20140273018
 Flow-through cell counting assay patent thumbnailFlow-through cell counting assay
A method for quantitatively measuring white blood cell (leukocyte) count and/or white blood cell (leukocyte) subsets count involves adding specific antibodies labeled with a marker to the biological fluid sample, capture of white blood cells from a fluid sample by a retainer, removal of other than leukocyte cells and other interfering substances by washing or using specific magnetic beads, and reading the result. The device for use in the present method includes a retainer for leukocyte cells and an absorption pad for taking up all excess washing solution flowing past the sample..
09/18/14
20140273000
 Methods for analyzing blood to detect diseases associated with abnormal protein aggregation patent thumbnailMethods for analyzing blood to detect diseases associated with abnormal protein aggregation
A method of detecting a disease associated with abnormal protein aggregation in a subject is provided, the method comprising (a) contacting leukocytes from the subject with a probe that binds to pathogenic protein aggregates, and (b) detecting the probe bound to the pathogenic protein aggregates, wherein the presence of pathogenic protein aggregates in the leukocytes is indicative that the subject has a disease associated with abnormal protein aggregation. In one embodiment, the disease is alzheimer's disease or mild cognitive impairment..
09/18/14
20140272943
 Rapid and highly fieldable viral diagnostic patent thumbnailRapid and highly fieldable viral diagnostic
The present invention relates to a rapid, highly fieldable, nearly reagentless diagnostic to identify active rna viral replication in a live, infected cells, and more particularly in leukocytes and tissue samples (including biopsies and nasal swabs) using an array of a plurality of vertically-aligned nanostructures that impale the cells and introduce a dna reporter construct that is expressed and amplified in the presence of active viral replication.. .
09/18/14
20140263070
 Methods and systems for the filterless reduction of leukocytes in a biological fluid patent thumbnailMethods and systems for the filterless reduction of leukocytes in a biological fluid
Methods and systems for removing leukocytes from a biological fluid are disclosed. The methods and systems include a device that has a magnetic substrate coated with one or more polymeric materials that have an adhesion or adsorption affinity for leukocytes..
09/11/14
20140256565
 Methods for hla typing patent thumbnailMethods for hla typing
The present invention relates to methods for reducing the ambiguity in human leukocyte antigen (hla) allele identification. In particular, the methods comprise using target specific oligonucleotide (tso) techniques to determine a first set of possible hla alleles.
09/04/14
20140248289
 Methods and compositions for the treatment of respiratory conditions via nkg2d inhibition patent thumbnailMethods and compositions for the treatment of respiratory conditions via nkg2d inhibition
Methods and compositions for the treatment of respiratory conditions are provided. Aspects of the subject methods include administering to the subject a composition comprising an inhibitor of nkg2d-mediated activation of leukocytes.
08/14/14
20140227711
Genotoxicity as a biomarker for inflammation
The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of dna damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation.
08/14/14
20140227272
Anti-leukocyte adhesion for the mitigation of potential adverse events caused by cd3-specific binding domains
The present invention relates in essence to a compound which decreases or inhibits the binding of mammalian t-cells to mammalian endothelial cells for use in a method of prophylaxis and/or amelioration and/or treatment of clinical adverse events caused by therapy which comprises re-directing of t-cells against target cells in a patient. Methods of treatment of patients having or being at risk of clinical adverse events caused by therapy which comprises re-directing of t-cells against target cells are also contemplated..
08/07/14
20140220572
Method and system to detect, diagnose, and monitor the progression of alzheimer's disease
Various embodiments provide methods for the detection, the diagnosis, and/or the progression monitoring of alzheimer's disease by observing the epigenetic markers in leukocytes. Methods for determining a state of alzheimer's disease are provided.
07/31/14
20140212960
Leukocyte measurement device and reagent kit
A leukocyte measurement device is provided with a spread inspection window at a position separated from an opening part along a spreading direction of a blood-derived sample in a carrier, for making the carrier visible from outside. When the blood-derived sample is dropped from the opening part, leukocytes contained in the blood-derived sample are captured by the carrier in the vicinity of a dropping position, while erythrocytes and/or hemoglobin and the like spread through the carrier from the dropping position into a predetermined direction.
07/10/14
20140190888
Methods, systems and devices for separating tumor cells
Embodiments of the present disclosure are directed to the separation/capture of specific cells and/or contaminants, as well as the determination, monitoring, and treatment of cancer. Moreover, some embodiments are directed to methods, systems and devices for removing cancer, stem and/or tumor cells in vivo or in vitro from a bodily fluid to prevent or impede the proliferation of a cancer.
07/03/14
20140186345
Method of administering an antibody
Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin. Preferably, no more than about 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month..
06/26/14
20140179807
Module-level analysis of peripheral blood leukocyte transcriptional profiles
The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into clusters; iteratively selecting gene expression values for one or more transcriptional modules by: selecting for the module the genes from each cluster that match in every disease or condition; removing the selected genes from the analysis; and repeating the process of gene expression value selection for genes that cluster in a sub-fraction of the diseases or conditions; and iteratively repeating the generation of modules.. .
06/26/14
20140179659
Method for suppressing surgical site infection and column to be used for the method
An object of the present invention is to provide a method for suppressing surgical site infections (ssi) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject.
06/19/14
20140170169
Blocking antibody for transplantation
A method can include administering a donor-specific human leukocyte antigen antibody to a tissue transplant recipient where the antibody is an immunoglobulin g subclass 4 antibody (g4). Various other examples of devices, assemblies, systems, methods, etc., are also disclosed..
06/05/14
20140154772
Inhibitors of human phosphatidylinositol 3-kinase delta
Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (pi3kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which pi3kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit pi3kδ, while not significantly inhibiting activity of other pi3k isoforms.
05/29/14
20140147470
Methods of predicting host responsiveness to cancer immunotherapies by ex vivo induction of leukocyte-function-associated mrnas
Embodiments of the invention relate generally to ex vivo methods of quantifying expression of leukocyte-function associated mrnas and using the quantification to characterize an individual's potential responsiveness to cancer immunotherapy. Certain embodiments relate to methods to monitor the efficacy of ongoing cancer immunotherapy by evaluating expression of leukocyte-function associated mrnas genes before and administration of an anti-cancer immunotherapy regimen..
05/22/14
20140141045
Allogeneic tumor cell vaccination
The present invention relates to cancer immunotherapy, specifically to allogeneic tumor cell vaccines. According to some embodiments, the invention provides novel cell lines useful as therapeutic cell vaccine compositions.
05/22/14
20140140984
Composition comprising herbal extracts or fermented products thereof having lactic acid bacteria for preventing or treating respiratory diseases
The present invention relates to a composition for preventing or treating respiratory diseases, and more particularly, to a pharmaceutical composition, and to a health food, comprising extracts of herbal mixtures or fermented products thereof having lactic acid bacteria as effective ingredients for preventing or treating respiratory diseases, wherein the herbal mixtures comprise: sophora flavascens, radix glycyrrhizae, flos lonicerae, angelicae gigantis radix, aralia continentalis, inula helenium, saposhnikoviae radix, zizyphus spinosa, houttuynia cordata, forsythiae fructus, arctium lappa, herba epimedii, ginseng, lithospermi radix, sanguisorbae radix, cnidii rhizoma, scrophulariae radix, and polygoni cuspidati radix. The herbal extracts or fermented products thereof having lactic acid bacteria exhibit the effects of significantly lowering an airway resistance value; reducing the numbers of leukocytes, neutrophilic leukocytes, lymphocytes, eosinocytes, and basophil leukocytes to levels similar to that of a normal group; and reducing the infiltration of inflammatory cells and eosinocyte cells near ahr on lung tissues.
05/15/14
20140134137
Use of stem cells to reduce leukocyte extravasation
The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in leukocytes.
05/01/14
20140121224
Quinazolinones as inhibitors of human phosphatidyositol 3-kinase delta
Compounds that inhibit pi3kδ activity, including compounds that selectively inhibit pi3kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (pi3kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which pi3kδ plays a role in leukocyte function, using the compounds also are disclosed..
05/01/14
20140121223
Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
Compounds that inhibit pi3kδ activity, including compounds that selectively inhibit pi3kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (pi3kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which pi3kδ plays a role in leukocyte function, using the compounds also are disclosed..
05/01/14
20140120530
Method for classifying/counting leukocytes, reagent kit for classifying leukocytes, and reagent for classifying leukocytes
The present invention provides a method for classifying and counting leukocytes which allows classification and count of normal leukocytes as well as discrimination between blast cells and atypical lymphocytes. The present invention also provides a regent kit and reagent for classifying leukocyte which are used for classifying and counting leukocytes in biological samples..
04/10/14
20140100188
Phenotyping tumor-infiltrating leukocytes
The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor infiltrating leukocytes for use in assessing risk of cancer recurrence and long term survival, and for developing a treatment regimen for a cancer patient..
04/10/14
20140099632
Preparation and use of nucleated red blood cell simulating particles and hematology control mixtures
The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product.
04/10/14
20140099254
Combination therapy for inducing immune response to disease
The present invention concerns combinations of two or more agents for inducing an immune response to cancer or infectious disease. Agents may include leukocyte redirecting complexes, antibody-drug conjugates, interferons (preferably interferon-α), and/or checkpoint inhibitor antibodies.
03/20/14
20140080151
Anti-himf antibodies to treat lung diseases
Hypoxia induced mitogenic factor (himf) is a member of the “found in inflammatory zone” (fizz)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown.
03/20/14
20140080132
Method and kit for predicting cytotoxicity
A method for predicting adcc activity in a subject, the method comprising the steps of: (a) preparing a biological sample from the subject, said sample including a leukocyte, (b) bringing a portion of the biological sample and an antibody into contact with each other, (c) detecting expression of at least one marker of adcc activity selected from the group consisting of tumor necrosis factor super family 15, chemokine cxcl3, and interleukin 6 in the leukocyte in (i) the portion of the sample brought into contact with the antibody and in (ii) another portion of the sample not brought into contact with the antibody, (d) comparing an expression level in portion (i) with the expression level in portion (ii); and (e) predicting presence of the cytotoxic activity when the expression level in portion (i) is higher than the expression level in portion (ii). .
03/13/14
20140073586
Compositions for the treatment of cancer, and methods for testing and using the same
A composition comprising leukotoxin proteins isolated from a bacterium is provided. In this composition, greater than 85% of the leukotoxin proteins are chemically modified at a basic amino acid residue, and the proteins induce cell death in myeloid leukocytes, while remaining substantially non-toxic to lymphoid leukocytes, lymphocytes, and red blood cells.
03/13/14
20140073569
Method for generating immunomodulatory cells, the cells prepared therefrom and use thereof
The present invention develops a straightforward and rapid method for generating immunomodulatory cells from peripheral mononuclear cells, comprising treating peripheral mononuclear cells with a hepatocyte growth factor (hgf) to induce differentiation of the peripheral mononuclear cells into immunomodulatory leukocytes. The present invention also provides an immunomodulatory cell prepared according to this method.
02/27/14
20140056929
Immunomodulation by controlling interferon-gamma levels with the long non-coding rna nest
Compositions and methods of modulating an immune response by controlling levels of interferon-gamma (ifn-γ) production by leukocytes are disclosed. Adjustment of ifn-γ levels is achieved by increasing or decreasing the activity of nest (nettoie salmonella pas theiler's [cleanup salmonella not theiler's]), a long non-coding rna that induces expression of ifn-γ.
02/20/14
20140051117
Mass spectrometric diagnosis of septicemia
The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from bloodstream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins or any residual fractions of blood particles such as erythrocytes and leukocytes, and can be directly identified by mass spectrometric measurement of their protein profiles.
02/20/14
20140050700
Ex-vivo treatment of peripheral blood leukocytes with ifn-lambda
The present invention provides a method of treating th2-associated diseases and disorders by modulating the expression or secretion of il-4, il-5 and il-13 using interferon lambda (ifn-λ). For th2-associated diseases and disorders, cells of a patient having a th2-associated disease or disorder are treated ex vivo, with ifn-λ and returned to the patient.
02/13/14
20140042081
Filter for removing substances from blood or from blood derivatives, and a method for obtaining it
A filter for removing substances, including leukocytes and platelets by way of non-limiting example, from whole blood or from blood derivatives, the filter includes a casing containing a layered filter element, at least one layer of this latter being coated with polyurethane; this polyurethane has a number average molecular weight between 10,000 and 20,000 dalton. A method for forming the layered filter element for a filter such as mentioned above, in which at least one layer of this filter element is impregnated with polyurethane by immersing it in a container of a mixture in which the polyurethane is present.
02/06/14
20140038230
A simple and affordable method for immunophenotyping using a microfluidic chip sample preparation with image cytometry
The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications the cost, size and complexity of the instruments prevents wider use, for example, cd4 analysis in hiv monitoring in resource-poor countries.
02/06/14
20140038179
Reagent and reagent kit for analysis of immature leukocyte
At least one dye for staining nucleic acid selected from the dyes of the formulae (i) and (ii), wherein x− is an anion.. .
02/06/14
20140037596
Use of stem cells to reduce leukocyte extravasation
The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in vascular endothelial cells.
01/23/14
20140023670
Cancer vaccine composition
A cancer vaccine composition for human leukocyte antigen (hla)-a*0206-positive persons, comprising a protein product of the tumor suppressor gene wt1 or a partial peptide thereof.. .


Popular terms: [SEARCH]

Leukocyte topics: Leukocytes, Immunogenic, Stem Cells, Immune System, Animal Model, Human Leukocyte Antigen, Transgenic, Stimulator, Macrophage, Thromboxane, Attenuated, Fibronectin, Chronic Obstructive Pulmonary Disease, Antagonist, Vaccination

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This listing is a sample listing of patent applications related to Leukocyte for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Leukocyte with additional patents listed. Browse our RSS directory or Search for other possible listings.
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