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|| List of recent Leukemia-related patents
| Method of treatment with prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin in-2-1h-one and derivatives thereof|
A prodrug can have a structure of formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition for use in treatment of fungus, cancer, dermatitis, superficial mycoses; inflammation, tinea pedis, tinea cruris, and tinea corporis, trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum, and microsporum canis, candidiasis (moniliasis), candida albicans, tinea (pityriasis) vesicolor, malassezia furfur, acute myeloid leukemia, acute lymphoid leukemia, chronic myelogenous leukemia, lymphoma or multiple myeloma..
The University Of Kansas
| S100 protein inhibitors for treating leukemia|
The present invention relates to a compound, composition and method for reducing or inhibiting the differentiation or development of progenitor blood cells into malignant cells, leukemia cells or physiologically pathological cells. Particularly, the invention describes the use of inhibitors of s100 proteins, including myeloid related proteins.
| Diagnosis and treatment of cancer expressing ilt3 or ilt3 ligand|
The present invention relates to methods of using the expression of iltl3 ligand or ilt3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ilt3-ligand expressing cancers, such as t-cell acute lymphoblastic leukemia (t-cell acute lymphoblastic leukemia), for example by administering ilt3, the extracellular domain of ilt3 or ilt3fc conjugated to a cytotoxic agent to kill the targeted cancer cell.
The Trustees Of Columbia University In The City Of New York
|Leukemic stem cell ablation|
A method for treating a leukemia patient that is resistant to a thymidine kinase inhibitor (tki) other than imantinib comprising administering a cephalotaxine to said patient until said patient demonstrates a hematological or cytological response to said leukemia.. .
Chemgenex Pharmaceuticals, Inc.
|Compositions and methods for treating cancers|
The present invention relates to compositions and methods for treating of cancer. In some embodiments, the invention relates to the use of agents that can modulate a component in the cdx2-klf4 signaling pathway to treat myelodysplastic syndromes (mds), acute myelogenous leukemia (aml), acute lymphocytic leukemia (all), adult t-cell leukaemia (atll), lymphoma, gastric cancer, multiple myeloma, or combinations thereof, or a condition associated with abnormal activity of the cdx2-klf4 signaling pathway..
Aptose Biosciences Inc.
|Method for ex-vivo purging in autologous transplantation|
The present invention concerns a new method for ex-vivo purging of cells in autologous transplantation, wherein the sample of taken cells is treated with a sufficient amount of a multimeric form of the soluble portion of fasl to kill malignant cells without substantially affecting viability of cells to be transplanted. Autologous stem cell transplantation (asct) following high-dose chemotherapy with or without radiotherapy has become the standard therapy for the majority of patients with large-cell lymphomas, multiple myeloma, and refractory/recidivating hodgkin's disease.
Topotarget Switzerland Sa
|Method of treatment of philadelphia chromosome positive leukemia|
The invention provides a method for the treatment of ph+ leukemia in a patient comprising administering to the patient (i) a bcr-abl tyrosine kinase inhibitor, and (ii) an agent which selectively binds to a cell surface receptor expressed on ph+ leukemic stem cells. The invention further provides for the use of (i) and (ii) in, or in the manufacture of a medicament for, the treatment of ph+ leukemia in a patient; and a composition for the treatment of ph+ leukemia in a patient comprising (i) and (ii); and kits comprising (i) and (ii).
|Novel bifunctional metnase/intnase inhibitors and related compositions and methods of treatment of cancer|
In preferred embodiments, compounds, compositions and methods of treatment of the invention are used to treat a patient suffering from leukemia (e.g. Acute myeloid leukemia (aml) and related cancers.
|Substituted aminopyrimidine compounds and methods of use|
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the pi3k enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which pi3k enzymes play a role in leukocyte function, and hyperproliferative disorders associated with pi3k activity, including but not limited to leukemias and solid tumors, in mammals, especially humans..
Calitor Sciences, Llc
|Substituted aminopyrimidine compounds and methods of use|
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the pi3k enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which pi3k enzymes play a role in leukocyte function, and hyperproliferative disorders associated with pi3k activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
Treating leukemia with a whole, leech saliva extract
Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° c.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech.
Biopep Solutions, Inc.
B cell surface reactive antibodies
The invention relates to antibodies that are reactive to the cell surface of cd19+ b cells, including b-cell chronic lymphocytic leukemia (b-cll) cells, and compositions and methods for using such antibodies, including in the diagnosis and treatment of disorders associated with cd19+ b cells, such as b-cll.. .
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
Medicament for the treatment of acute myeloid leukemia (aml)
The present invention relates to the therapeutic treatment of acute myeloid leukemia (aml). It concerns in particular a novel composition for the treatment of this cancer and an associated therapeutic treatment method.
Triazolone compounds and uses thereof
The invention disclosed herein is directed to compounds of formula (i) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of formula (i), or a pharmaceutically acceptable salt thereof.
Inception 2, Inc.
Compounds and methods for kinase modulation, and indications therefor
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of b-raf, b-raf v600e and c-raf-1 protein kinase.
Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis
The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent.
Amderma Pharmaceuticals, Llc
Monitoring health and disease status using clonotype profiles
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using dna sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions.
Quantitative multiplex methylation-specific pcr
Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation specific pcr (qm-msp), multiple genes can be quantitatively evaluated from samples usually yielding sufficient dna for analyses of only 1 or 2 genes.
The Johns Hopkins University
Method for treating infectious diseases using emissive energy
The present invention relates to the treatment of infectious diseases, specifically by extracorporeally eradicating the pathogen. This invention comprises methods for the extracorporeal treatment of infectious diseases that will remove infectious pathogens (leukemia cells, bacteria, viruses, or fungi causing a septicemia, metastatic cancer cells, target protein, viruses, parasites, fungi and prions) in humans by targeting such pathogens with a laser or other high-energy source of emissive radiation.
Marv Enterprises, Llc
Methods of predicting clinical outcome of chronic lymphocytic leukemia
Provided are methods of predicting the outcome of a chronic lymphocytic leukemia (cll) in a subject. The methods comprise performing a polymerase chain reaction assay for an igh locus on a nucleic acid from a biological sample from a subject with cll, wherein the pcr assay amplifies a non-coding region of the igh locus, sequencing a product from the pcr assay, and determining a level of mutation in the non-coding region of the igh locus.
University Of Rochester
Compounds from anisomeles heyneana
The present invention describes use of compounds of formula 1 or 2 or their compositions for the treatment of leukemia and use of compound of formula 1 or its composition for treatment of infections caused due to m. Tuberculosis.
Council Of Scientific & Industrial Research
Combinations useful for the treatment of chronic lymphocytic leukemia
The invention relates to a combination which comprises (a) a dna damaging agent; and (b) 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidioyl]amino]-n-[5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide (“nilotinib”); a pharmaceutical composition comprising such a combination and optionally at least one pharmaceutical acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment chronic lymphocytic leukemia (cll); the use of such a combination for the preparation of a medicament for the treatment of cll; a commercial package or product comprising such a combination; and to a method of treatment of a warm-blooded animal, especially a human.. .
Inhibitors of c-fms kinase
Wherein z, x, j, r2 and w are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of formula i, are also provided..
Method of treating leukemia using rice prolamin
The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (pbmc) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells.
Mackay Memorial Hospital
Methods and biomarkers for detection and treatment of mature t-cell leukemia
The present invention relates to methods and biomarkers for detection and characterization of mature t-cell neoplasias/leukemias (e.g., t-cell prolymphocytic leukemia, sezary syndrome) in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples).. .
The Regents Of The University Of Michigan
Heterocyclic compounds and their uses
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (sle), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, the present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as acute myeloid leukaemia (aml) myelo-dysplastic syndrome (mds) myelo-proliferative diseases (mpd) chronic myeloid leukemia (cml) t-cell acute lymphoblastic leukaemia (t-all) b-cell acute lymphoblastic leukaemia (b-all) non hodgkins lymphoma (nhl) b-cell lymphoma and solid tumors, such as breast cancer.. .
Nitrogen-containing heterocyclic compound or salt thereof
The object is to provide an fms-like tyrosine kinase 3 (flt3) inhibitor useful as a therapeutic agent for acute myeloid leukemia (aml). A novel nitrogen-containing heterocyclic compound represented by the general formula  or a salt thereof is provided.
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Leukemia topics: Myelogenous, Myelogenous Leukemia, Proliferative, Autoimmune, Stem Cells, Breast Cancer, Rheumatoid Arthritis, Myeloid Leukemia, Acute Myelogenous Leukemia, Lymphocytic, Chronic Lymphocytic Leukemia, Lymphocytic Leukemia, Epigenetic, Multiple Myeloma, Polyphenol
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