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Leukemia patents



      
           
This page is updated frequently with new Leukemia-related patent applications. Subscribe to the Leukemia RSS feed to automatically get the update: related Leukemia RSS feeds. RSS updates for this page: Leukemia RSS RSS


Date/App# patent app List of recent Leukemia-related patents
08/28/14
20140243382
 Inhibitors of c-fms kinase patent thumbnailnew patent Inhibitors of c-fms kinase
Wherein z, x, j, r2 and w are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of formula i, are also provided..
08/28/14
20140243331
 Inhibitors of inv(16) leukemia patent thumbnailnew patent Inhibitors of inv(16) leukemia
This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (aml). The inv(16) fusion results in expression of the cbfβ-smmhc fusion protein in the blood cells of afflicted patients.
08/28/14
20140243315
 Pyrrolopyrimidine compounds for the treatment of cancer patent thumbnailnew patent Pyrrolopyrimidine compounds for the treatment of cancer
The ectopic expression of mer receptor tyrosine kinase (mer) has been identified as a tumor cell survival gene product in acute lymphoblastic leukemia (all) cells and a potential cause of all chemoresistance. Hence, we investigated whether the development of small molecule mer inhibitors was possible.
08/28/14
20140242590
 Flt3 mutations associated with drug resistance in aml patients having activating mutations in flt3 patent thumbnailnew patent Flt3 mutations associated with drug resistance in aml patients having activating mutations in flt3
The invention provides methods and compositions for identifying acute myeloid leukemia (aml) patients that have an increased likelihood of a relapse following treatment with ac 220.. .
08/21/14
20140235933
 Genetic modification of rats patent thumbnailGenetic modification of rats
Compositions and methods are provided for making rat pluripotent and totipotent cells, including rat embryonic stem (es) cells. Compositions and methods for improving efficiency or frequency of germline transmission of genetic modifications in rats are provided.
08/21/14
20140235700
 Lentiviral vectors pseudotyped with mutant baev glycoproteins patent thumbnailLentiviral vectors pseudotyped with mutant baev glycoproteins
The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (baev) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (mlv) envelope glycoprotein; or—a modified baev envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory r peptide.. .
08/21/14
20140235633
 4-aminoquinazoline derivatives and uses thereof patent thumbnail4-aminoquinazoline derivatives and uses thereof
The present invention provides a 4-aminoquinazoline derivative having the chemical structure of the following formula, and the use thereof. It is demonstrated by the pharmacological experiment that, the compound or a salt thereof according to the present invention not only has distinct inhibitory effect on histone deacetylases, but also has stronger differentiation induction and anti-proliferative activities for certain tumor cells.
08/21/14
20140235621
 Hematopoietic neoplasm chemotherapy patent thumbnailHematopoietic neoplasm chemotherapy
A method and medicament for treating mixed lineage leukemia; translocated mixed lineage leukemia; translocated mixed lineage leukemia based acute myelogenous leukemia; translocated mixed lineage leukemia based acute lymphoid leukemia; a non-mll based chronic myeloproliferative disorder, or non-mll based acute lymphoid leukemia is provided.. .
08/21/14
20140235454
 Monitoring health and disease status using clonotype profiles patent thumbnailMonitoring health and disease status using clonotype profiles
There is a need or improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using dna sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions.
08/14/14
20140227277
 Combination therapy with an anti-cd19 antibody and a purine analog patent thumbnailCombination therapy with an anti-cd19 antibody and a purine analog
The present disclosure describes a pharmaceutical combination of an anti-cd19 antibody and a purine analog for the treatment of non-hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.. .
08/14/14
20140227178
Humanized anti-hla-dr antibodies
The present invention concerns compositions and methods of use of humanized anti-hla-dr antibodies. In preferred embodiments, the antibodies induce apoptosis and inhibit proliferation of lymphoma cells without inducing cdc or adcc.
08/07/14
20140220561
Quantitative multiplex methylation-specific pcr
Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation specific pcr (qm-msp), multiple genes can be quantitatively evaluated from samples usually yielding sufficient dna for analyses of only 1 or 2 genes.
07/31/14
20140213630
Methods and pharmaceutical compositions for treating lymphoid malignancy
The present invention provides, inter alia, methods for treating, preventing, or ameliorating the effects of a lymphoid malignancy, such as those associated with a mutated phosphatase and tensin homolog (pten) gene, or t-cell acute lymphoblastic leukemia (t-all). These methods include administering to a subject an effective amount of a phosphoinositide 3-kinase-delta (pi3kδ) inhibitor and a phosphoinositide 3-kinase-gamma (pi3kγ) inhibitor.
07/24/14
20140206694
Heterocyclic compounds and their uses
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (sle), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, the present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as acute myeloid leukaemia (aml) myelo-dysplastic syndrome (mds) myelo-proliferative diseases (mpd) chronic myeloid leukemia (cml) t-cell acute lymphoblastic leukaemia (t-all) b-cell acute lymphoblastic leukaemia (b-all) non hodgkins lymphoma (nhl) b-cell lymphoma and solid tumors, such as breast cancer.. .
07/24/14
20140206631
Cardiac glycoside analogs in combination with emodin for cancer therapy
A method and medicine for treating leukemia or other cancer includes administering to a patient diagnosed with leukemia or other cancer a treatment regimen that includes periodic doses of a combination of emodin and digoxin.. .
07/24/14
20140206624
Treatment of leukemia
Compositions and methods for the treatment of leukemia by inhibiting foxo signaling are described.. .
07/24/14
20140205680
Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid.
07/24/14
20140205568
Promyelocytic leukemia protein as a redox sensor
The present invention relates to a method for determining the redox status of a cell or tissue comprising a step consisting of determining the level of pml nuclear bodies in said cell or tissue.. .
07/17/14
20140200247
Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazoles orotate formulations
New polymorphs of 5-amino or substituted amino 1,2,3-triazole and substituted derivatives thereof, of orotates of the carboxyamidotriazoles, of formulations of the triazoles and orotic acid in the ratio of 1:1 to 1:4 (base:acid) and of safer processes of the preparation of the same are disclosed. The compounds are useful in the control and treatment of diseases including, but not limited to solid cancers, macular degeneration, retinopathy, chronic myeloid leukemia, aids and diseases which rely on aberrant signal transduction.
07/17/14
20140200245
Inhibitors of c-fms kinase
Wherein z, x, j, r2 and w are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of formula i, are also provided..
07/17/14
20140199378
New natural and synthetic compounds for treating cancer and other diseases
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
07/10/14
20140194632
Method for screening for compounds selectively interacting with rad9
Natural and synthetic compounds of formulae ia-ie having a lactone structure, in particular securolide, have been determined to be effective anti-tumor compounds which target the hrad9 gene and/or protein encoded thereby or complex containing the protein and/or the p53 gene and/or protein. Securolide is cytoselective for mutants of hrad9 based on studies conducted in rad9 mutant yeast strains.
07/10/14
20140193420
Diagnosis and treatment of cancer using anti-itm2a antibody
Disclosed is a monoclonal antibody binding to an itm2a protein. This antibody is useful in the diagnosis, prevention, and treatment of cancer such as ewing's sarcoma, t cell leukemia, t cell lymphoma, acute myeloid leukemia, b cell tumor, and multiple myeloma.
07/10/14
20140193333
Therapeutic and diagnostic target
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases..
07/03/14
20140187604
Therapeutic and diagnostic target gene in acute myeloid leukemia
Methods are provided for treating a cancer in a subject comprising administering to the subject an agent which inhibits expression of an hlx gene in the subject, or an agent which inhibits activity of an expression product of the hlx gene, and also for diagnosing a subject as likely to develop a cancer comprising determining whether a stem cell obtained from the subject expresses a hlx gene at a level in excess of predetermined control level. Kits therefor are also provided..
07/03/14
20140186376
Compositions and methods for inhibiting ccl3
The present invention relates to the discovery that ccl3, through at least one of its receptors ccr1 and ccr5, plays a role in the pathologies associated with myeloid neoplasms. In various embodiments, the pathologies associated with myeloid neoplasms treatable by the compositions and methods of the invention described herein include, but are not limited to, at least one of osteoclast/osteoblast imbalance, inhibition of osteoblast function, bone loss, disregulation of the hematopoietic stem cell microenvironment, abnormal hematopoietic recovery, pancytopenia, anemia, thrombocytopenia, neutropenia, bicytopenia, and erythrocytopenia.
06/26/14
20140179626
Acadesine derivatives, products and compositions including same, therapuetic uses thereof, and methods for synthesizing same
Acadesine derivatives as a drug, as well as the derivatives for the treatment of cancer and in particular for the treatment of chronic myeloid leukemia are described. Also, product containing the derivatives and at least one second active ingredient as a combination product for simultaneous, separate or sequential administration, in the treatment of cancer, as well as a pharmaceutical composition containing the derivatives and a pharmaceutically acceptable carrier are described.
06/19/14
20140172321
Leukemia classification using cpd data
Embodiments of the present invention encompass automated systems and methods for predicting an acute leukemia sub-type of an individual diagnosed with acute leukemia based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (dc) impedance, radiofrequency (rf) conductivity, and/or light measurement data obtained from the biological sample with an acute leukemic sub-type of the individual..
06/12/14
20140161825
Methods of treating acute myeloid leukemia by blocking cd47
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. Leukemias, solid tumors including carcinomas, etc..
06/12/14
20140161805
Methods for manipulating phagocytosis mediated by cd47
Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. Circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells.
06/05/14
20140155635
Resorcylic acid lactone compounds
Disclosed are a novel resorcyclic acid lactone compound with inhibitory activity against protein kinases, a pharmaceutically acceptable salt thereof, a method for the synthesis thereof, and a pharmaceutical composition for the treatment and prevention of various cancer diseases comprising the same as an active ingredient. The novel resorcyclic acid lactone compound is useful as a therapeutic for cancer diseases, especially blood cancer, inter alia, acute myeloid leukemia (aml)..
06/05/14
20140154304
Combination therapy with volasertib
Disclosed is the use of volasertib or a salt or a hydrate thereof for treating patients suffering from acute myeloid leukemia (aml) comprising administering a high dose of volasertib in combination with fludarabine, cytarabine and granulocyte colony-stimulating factor (gcsf) or in combination with fludarabine, cytarabine, gcsf and a daunorubicin citrate liposome injection.. .


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Leukemia topics: Myelogenous, Myelogenous Leukemia, Proliferative, Autoimmune, Stem Cells, Breast Cancer, Rheumatoid Arthritis, Myeloid Leukemia, Acute Myelogenous Leukemia, Lymphocytic, Chronic Lymphocytic Leukemia, Lymphocytic Leukemia, Epigenetic, Multiple Myeloma, Polyphenol

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This listing is a sample listing of patent applications related to Leukemia for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Leukemia with additional patents listed. Browse our RSS directory or Search for other possible listings.
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