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|| List of recent Leukemia-related patents
| Novel bifunctional metnase/intnase inhibitors and related compositions and methods of treatment of cancer|
In preferred embodiments, compounds, compositions and methods of treatment of the invention are used to treat a patient suffering from leukemia (e.g. Acute myeloid leukemia (aml) and related cancers.
| Substituted aminopyrimidine compounds and methods of use|
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the pi3k enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which pi3k enzymes play a role in leukocyte function, and hyperproliferative disorders associated with pi3k activity, including but not limited to leukemias and solid tumors, in mammals, especially humans..
Calitor Sciences, Llc
| Substituted aminopyrimidine compounds and methods of use|
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the pi3k enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which pi3k enzymes play a role in leukocyte function, and hyperproliferative disorders associated with pi3k activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
| Treating leukemia with a whole, leech saliva extract|
Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° c.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech.
Biopep Solutions, Inc.
| B cell surface reactive antibodies|
The invention relates to antibodies that are reactive to the cell surface of cd19+ b cells, including b-cell chronic lymphocytic leukemia (b-cll) cells, and compositions and methods for using such antibodies, including in the diagnosis and treatment of disorders associated with cd19+ b cells, such as b-cll.. .
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
| Medicament for the treatment of acute myeloid leukemia (aml)|
The present invention relates to the therapeutic treatment of acute myeloid leukemia (aml). It concerns in particular a novel composition for the treatment of this cancer and an associated therapeutic treatment method.
|Triazolone compounds and uses thereof|
The invention disclosed herein is directed to compounds of formula (i) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of formula (i), or a pharmaceutically acceptable salt thereof.
Inception 2, Inc.
|Compounds and methods for kinase modulation, and indications therefor|
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of b-raf, b-raf v600e and c-raf-1 protein kinase.
|Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis|
The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent.
Amderma Pharmaceuticals, Llc
|Monitoring health and disease status using clonotype profiles|
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using dna sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions.
Quantitative multiplex methylation-specific pcr
Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation specific pcr (qm-msp), multiple genes can be quantitatively evaluated from samples usually yielding sufficient dna for analyses of only 1 or 2 genes.
The Johns Hopkins University
Method for treating infectious diseases using emissive energy
The present invention relates to the treatment of infectious diseases, specifically by extracorporeally eradicating the pathogen. This invention comprises methods for the extracorporeal treatment of infectious diseases that will remove infectious pathogens (leukemia cells, bacteria, viruses, or fungi causing a septicemia, metastatic cancer cells, target protein, viruses, parasites, fungi and prions) in humans by targeting such pathogens with a laser or other high-energy source of emissive radiation.
Marv Enterprises, Llc
Methods of predicting clinical outcome of chronic lymphocytic leukemia
Provided are methods of predicting the outcome of a chronic lymphocytic leukemia (cll) in a subject. The methods comprise performing a polymerase chain reaction assay for an igh locus on a nucleic acid from a biological sample from a subject with cll, wherein the pcr assay amplifies a non-coding region of the igh locus, sequencing a product from the pcr assay, and determining a level of mutation in the non-coding region of the igh locus.
University Of Rochester
Compounds from anisomeles heyneana
The present invention describes use of compounds of formula 1 or 2 or their compositions for the treatment of leukemia and use of compound of formula 1 or its composition for treatment of infections caused due to m. Tuberculosis.
Council Of Scientific & Industrial Research
Combinations useful for the treatment of chronic lymphocytic leukemia
The invention relates to a combination which comprises (a) a dna damaging agent; and (b) 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidioyl]amino]-n-[5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide (“nilotinib”); a pharmaceutical composition comprising such a combination and optionally at least one pharmaceutical acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment chronic lymphocytic leukemia (cll); the use of such a combination for the preparation of a medicament for the treatment of cll; a commercial package or product comprising such a combination; and to a method of treatment of a warm-blooded animal, especially a human.. .
Inhibitors of c-fms kinase
Wherein z, x, j, r2 and w are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of formula i, are also provided..
Method of treating leukemia using rice prolamin
The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (pbmc) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells.
Mackay Memorial Hospital
Methods and biomarkers for detection and treatment of mature t-cell leukemia
The present invention relates to methods and biomarkers for detection and characterization of mature t-cell neoplasias/leukemias (e.g., t-cell prolymphocytic leukemia, sezary syndrome) in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples).. .
The Regents Of The University Of Michigan
Heterocyclic compounds and their uses
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (sle), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, the present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as acute myeloid leukaemia (aml) myelo-dysplastic syndrome (mds) myelo-proliferative diseases (mpd) chronic myeloid leukemia (cml) t-cell acute lymphoblastic leukaemia (t-all) b-cell acute lymphoblastic leukaemia (b-all) non hodgkins lymphoma (nhl) b-cell lymphoma and solid tumors, such as breast cancer.. .
Nitrogen-containing heterocyclic compound or salt thereof
The object is to provide an fms-like tyrosine kinase 3 (flt3) inhibitor useful as a therapeutic agent for acute myeloid leukemia (aml). A novel nitrogen-containing heterocyclic compound represented by the general formula  or a salt thereof is provided.
Chimeric molecule involving oligomerized fasl extracellular domain
New chimeric molecules involving in their structure, a combination of the extracellular domain (ec) of the fasl protein and a domain enabling oligomerisation of this fas ligand (fasl) ec domain, such as the ig-like (so-called ig in the following pages) domain of the gp190 receptor for the leukemia inhibitory factor (lif), or involving in their structure variants of the domains. Also, compositions including the chimeric molecule defined herein and the use of these chimeric molecules especially to trigger cytotoxic activity toward cells sensitive to fasl..
Centre National De La Recherche Scientifique
Pyrimidine compounds for the treatment of cancer
Described are compounds of formula i or formula ii: wherein: ring a is a 5- or 6-membered heteroaryl group; dashed lines are optional double bonds; x is n or o; y is a carbon atom or an s or n heteroatom in ring a in any suitable location; and substituents are as given herein. Compositions containing the same and methods of using the same in treating cancers such as acute lymphoblastic leukemia are also described..
The University Of North Carolina At Chapel Hill
Combination therapy for the treatment of cancer
Described are methods and compositions for treating cancer that include a dopamine receptor (dr) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a dna synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel.
Method for multiplex-detecting chronic myelogenous leukemia gene using cleavable probe
One embodiment of the present invention provides a detection kit for detecting a chronic myelogenous leukemia (cml) gene expression, wherein the detection kit includes a primer set which is specifically bound to the cml gene; and a cleavable probe which is specifically bound to the inside of a cml gene amplification product which is amplified by the primer set. Another embodiment of the present invention provides a method of measuring the cml gene expression by using the detection kit according to one embodiment of the present invention.
Samsung Life Public Welfare Foundation
Combination therapy with anti-cd74 antibodies provides enhanced toxicity to malignancies, autoimmune disease and other diseases
Disclosed are compositions and methods comprising combinations of anti-cd74 antibodies with a therapeutic agent that is attached to the anti-cd74 antibody or separately administered. Preferably, the therapeutic agent is an antibody that binds to an antigen different from cd74, such as cd19, cd20, cd21, cd22, cd23, cd37, cd40, cd40l, cd52, cd80, il-6, cxcr4 or hla-dr.
Ibc Pharmaceuticals, Inc.
Combination treatment of acute myeloid leukemia and myelodysplastic syndrome ii
The present invention relates to the use of volasertib or a salt thereof or the hydrate thereof in combination with azacitidine or a salt thereof or the hydrate thereof for treating patients suffering from acute myeloid leukemia (aml) or myelodysplastic syndrome (mds).. .
Boehringer Ingelheim International Gmbh
Combination treatment of acute myeloid leukemia and myelodysplastic syndrome i
The present invention relates to the use of volasertib or a salt thereof or the hydrate thereof in combination with decitabine or a salt thereof or the hydrate thereof for treating patients suffering from acute myeloid leukemia (aml) or myelodysplastic syndrome (mds).. .
Boehringer Ingelheim International Gmbh
Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia
Gene mutations are associated with the progression of acute myeloid leukemia (aml). The invention relates to methods and systems for evaluating the progression of aml based on these gene mutations.
Memorial Sloan-kettering Cancer Center
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Leukemia topics: Myelogenous, Myelogenous Leukemia, Proliferative, Autoimmune, Stem Cells, Breast Cancer, Rheumatoid Arthritis, Myeloid Leukemia, Acute Myelogenous Leukemia, Lymphocytic, Chronic Lymphocytic Leukemia, Lymphocytic Leukemia, Epigenetic, Multiple Myeloma, Polyphenol
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