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|| List of recent Leukemia-related patents
|Methods of treating and preventing leukemia and other cancers of the blood and bone|
The present invention relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by inhibiting gut-derived serotonin. The inhibition of the gut-derived serotonin is accomplished by inhibiting tph1, an enzyme responsible for the production of gut-derived serotonin.
|Method of treating mixed lineage leukemia gene-rearranged acute lymphoblastic leukemias|
The present invention relates to a method of treating a warm-blooded animal, especially a human, having mixed lineage leukemia (mll rearranged all) comprising administering to said animal a therapeutically effective amount of a staurosporine derivative, especially pkc412 or a pharmaceutically acceptable salt thereof, alone or in combination with further therapeutic measures, for example, those defined herein; to the use of a staurosporine derivative for the preparation of a medicament for the treatment of mll rearranged all; and to a commercial package comprising a staurosporine derivative together with instructions for its use in the treatment of mll rearranged all.. .
The invention provides derivatives of decitabine with superior chemical stability and shelf life, with similar physiological activity. The derivatives are provided in a non-aqueous formulation, which further stabilizes the derivatives.
|Zap-70 detection in chronic lymphocytic leukemia|
Detection of zap-70 expression provides important information about disease progression and overall survival in patients with chronic lymphocytic leukemia (cll). The invention provides methods for diagnosing cll in a subject, as well as methods for clearly distinguishing cll patients with aggressive form of the disease.
|Compositions and methods for cancer and cancer stem cell detection and elimination|
In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded rna-specific adenosine deaminases, or adar, enzymes.
|Combination cancer therapy with an hsp90 inhibitor and an antimetabolite|
The invention provides a method of treating a subject with cancer, particularly leukemia, lymphoma, solid cancer such as colorectal cancer, gastric cancer, bladder cancer, non-small cell lung cancer, and breast cancer, comprising administering to the subject a compound of formulae (i) 40 or (ia) in combination with an antimetabolite such as methotrexate, pemetrexed, cytarabine or nelarabine, or 5-fluorouracil, or capecitabine or their derivatives.. .
|T cell receptor-like antibodies specific for a wti peptide presented by hla-a2|
The present invention provides antigen binding proteins that specifically bind to wilms' tumor protein (wt1), including humanized, chimeric and fully human antibodies against wt1, antibody fragments, chimeric antigen receptors (cars), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to hla-a0201-restricted wt1 peptide.
|Pgam1 inhibitors and methods related thereto|
In certain embodiments, the disclosure relates to methods of treating or preventing a pgam1 mediated condition such as cancer or tumor growth comprising administering an effective amount of pgam1 inhibitor, for example, an anthracene-9,10-dione derivative to a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, head and neck cancer, and leukemia, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof..
|Use of carbamide peroxide injection in preparation of virus inactivation medicaments for treating diseases|
The invention relates to the field of medicament use, in particular to the clinical use of carbamide peroxide injection series for virus inactivation in the treatment of blood vessel plaque, leukemia, aids and hepatitis, etc. The invention utilizes the affinity of photosensitizers to blood vessel plaque focus, leukemia cells, tumor, and/or virus, which is several times higher than that to normal tissues, so as to destroy focus cells or virus by generating sufficient singlet oxygen (1o2) under the effect of a method using laser, x-ray, ultrasound and medicament, etc., while in condition of using carbamide peroxide injection series.
|N-methyl-2-[3-((e)-2-pyridin-2-yl-vinyl)-1h-indazol-6-ylsulfanyl]-benzamide for the treatment of chronic myelogenous leukemia|
The present invention relates to a method of treating chronic myelogenous leukemia in a subject comprising administering to the subject a compound, such as n-methyl-2-[3-((e)-2-pyridin-2-yl-vinyl)-1h-indazol-6-ylsulfanyl]-benzamide, that inhibits the t315i mutation in bcr-abl tyrosine kinase, or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition comprising a compound such as n-methyl-2-[3-((e)-2-pyridin-2-yl-vinyl)-1h-indazol-6-ylsulfanyl]-benzamide, that inhibits the t315i mutation in bcr-abl tyrosine kinase, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent..
|Chimeric antigen receptor specific for folate receptor beta|
The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (aml). The invention also relates to at least one chimeric antigen receptor (car) specific to folate receptor beta (frβ), vectors comprising the same, and recombinant t cells comprising the frβ car.
|Notch agonists for the treatment of cancer|
The present invention is directed to methods of treating and preventing acute myeloid leukemia and acute myeloid leukemia relapse disease in a subject that involve administering a notch receptor agonist.. .
|Methods, pharmaceutical compositions and kits for use in the treatment of adult t-cell leukemia/lymphoma|
The present invention relates to methods, pharmaceutical compositions and kits for use in the treatment of adult t-cell leukemia/lymphoma. More particularly, the present invention relates to a combination of an interferon, an arsenic compound and a reverse transcriptase inhibitor for the treatment of adult t-cell leukemia/lymphoma..
|Indirubin derivatives, and uses thereof|
Indirubin is the major active anti-tumor component of a traditional chinese herbal medicine used for treatment of chronic myelogenous leukemia (cml). Indirubin derivatives (irds) potently reduce the viabilities of various cancer cells and affect kinase activities.
|Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof|
The present invention relates generally to thienopyrimidine and thienopyridine class compounds and methods of use thereof. In particular embodiments, the present invention provides compositions comprising thienopyrimidine class compounds and methods of use to inhibit the interaction of menin with mll1, mll2 and mll-fusion oncoproteins (e.g., for the treatment of leukemia, solid cancers and other diseases dependent on activity of mll1 and mll2 or menin)..
|Methods of treating hematologic cancers|
This disclosure relates to the treatment of hematologic cancers, for example, cancers of the blood, by methods that include administration of egcg and at least one of a purine nucleoside analog and an alkylating agent. In particular, methods of treating chronic lymphocytic leukemia (cll) and acute lymphocytic leukemia (all) are described..
|Leukemia stem cell markers|
The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (aml) comprising (1) measuring the expression level of human leukemic stem cell (lsc) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value; an lsc-targeting therapeutic agent for aml capable of suppressing the expression of a gene selected from among lsc marker genes or a substance capable of suppressing the activity of a translation product of the gene; a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for aml patients, comprising obtaining an lsc-purged sample with at least 1 kind of lsc marker as an index; and a method of preventing or treating aml.. .
|Use of photosensitizer in preparation of virus-inactivating medicaments for treating diseases|
The invention relates to the field of medicament use, in particular to the clinical use of photosensitizers for inactivating viruses in the treatment of blood vessel plaque, leukemia, aids, hepatitis and the like. The invention is based on the affinity of photosensitizer to blood vessel plaque focus, leukemia cells, tumor, and/or virus, which is several times higher than that to normal tissues, to destroy focus cells or virus by generating singlet oxygen (1o2) under the effect of a method using laser, x-ray, ultrasound and medicament.
|Markers of acute myeloid leukemia stem cells|
Markers of acute myeloid leukemia stem cells (amlsc) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets..
|Combination therapy with an anti - cd19 antibody and a nitrogen mustard|
The present disclosure describes a pharmaceutical combination of an anti-cd19 antibody and a nitrogen mustard for the treatment of non-hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.. .
|Method of treating leukemia in a mammal|
The present invention provides a method of treating a leukemia in a mammal comprising sequentially administering to the mammal an amount of an immunotoxin and an amount of a chemotherapeutic agent effective to treat the leukemia.. .
|Pharmaceutical composition comprising albumin-binding arginine deiminase for cancer targeting treatment|
The present invention provides a pharmaceutical composition containing albumin-binding arginine deiminase fusion protein (aad) for treating cancer or other arginine-dependent diseases. The aad fusion protein can be purified from both soluble and insoluble fractions of crude proteins, it binds to human serum albumin (hsa) and has its high activity with longer half life for efficient depletion of arginine in cancer cells.
|Leukemia stem cell targeting ligands and methods of use|
The present invention is directed to c-type lectin-like molecule-1 (cll1) specific ligand peptides, comprising the amino acid motif lr(s/t), and methods of their use, e.g., for imaging detection for diagnosis of leukemia and the presence of leukemic stem cells (lscs) and targeted therapy against leukemia mediated at least in part by cll1-expressing lscs.. .
|Anti-cd33 antibodies and methods for treatment of acute myeloid leukemia using the same|
The present invention relates to antibodies that bind cd33. More particularly, the invention relates to anti-cd33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved versions of these antibodies, immunoconjugates and compositions comprising these antibodies, and the uses of same in diagnostic, research and therapeutic applications.
|Inhibitors of c-fms kinase|
Wherein z, x, j, r2 and w are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of formula i, are also provided..
|Inhibitors of inv(16) leukemia|
This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (aml). The inv(16) fusion results in expression of the cbfβ-smmhc fusion protein in the blood cells of afflicted patients.
|Pyrrolopyrimidine compounds for the treatment of cancer|
The ectopic expression of mer receptor tyrosine kinase (mer) has been identified as a tumor cell survival gene product in acute lymphoblastic leukemia (all) cells and a potential cause of all chemoresistance. Hence, we investigated whether the development of small molecule mer inhibitors was possible.
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Leukemia topics: Myelogenous, Myelogenous Leukemia, Proliferative, Autoimmune, Stem Cells, Breast Cancer, Rheumatoid Arthritis, Myeloid Leukemia, Acute Myelogenous Leukemia, Lymphocytic, Chronic Lymphocytic Leukemia, Lymphocytic Leukemia, Epigenetic, Multiple Myeloma, Polyphenol
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