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Leukemia patents

      

This page is updated frequently with new Leukemia-related patent applications.




Date/App# patent app List of recent Leukemia-related patents
08/18/16
20160237118 
 Leukemia stem cell targeting ligands and methods of use patent thumbnailLeukemia stem cell targeting ligands and methods of use
The present invention is directed to c-type lectin-like molecule-1 (cll1) specific ligand peptides, comprising the amino acid motif lr(s/t), and methods of their use, e.g., for imaging detection for diagnosis of leukemia and the presence of leukemic stem cells (lscs) and targeted therapy against leukemia mediated at least in part by cll1-expressing lscs.. .
The Regents Of The University Of California


08/18/16
20160237043 
 Kdm1a inhibitors for the treatment of disease patent thumbnailKdm1a inhibitors for the treatment of disease
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of kdm1a, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia..
Imago Biosciences, Inc.


08/18/16
20160235679 
 High surface-area lyophilized compositions comprising arsenic for oral administration in patients patent thumbnailHigh surface-area lyophilized compositions comprising arsenic for oral administration in patients
The present invention relates to treating malignancies such as tumors or cancers by orally administering lyophilized compositions comprising arsenic to a subject in such need. Malignancies include various hematological malignancies, such as acute myeloid leukemia (aml) including acute promyelocytic leukemia (apl), myelodysplastic syndrome (mds), multiple myeloma (mm) and lymphomas and solid tumors including glioblastoma multiforme and breast cancer.
Orsenix Bv


08/11/16
20160228410 
 An anti-leukemic agent useful for inducing differentiation in myeloid leukemia cells patent thumbnailAn anti-leukemic agent useful for inducing differentiation in myeloid leukemia cells
The present invention provides the compound ormeloxifene [3,4-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy)phenyl-7-methoxy chroman] as useful in inducing differentiation in wide range of myeloid leukemias including acute promyelocytic leukemia, acute myeloid leukemia and chronic myeloid leukemia where block in differentiation is common feature. Ormeloxifene induced differentiation that is marked by increase in differentiation marker proteins like c/ebpα and surface proteins such as cd11b and granulocyte colony stimulating factor receptor (gcsfr).
Council Of Scienticfic & Industrial Research


08/04/16
20160222464 
 Prognostic methods, compositions and kits for prediction of acute lymphoblastic leukemia (all) relapse patent thumbnailPrognostic methods, compositions and kits for prediction of acute lymphoblastic leukemia (all) relapse
The present invention relates to prognostic methods and kits for the assessment and monitoring of relapse-free or disease-free survival of all patients. The detection is based on the use of detecting nucleic acids, specific for determination of the expression of at least one of mir-151-5p and mir-451 in a test sample.
Mor Research Applications Ltd.


08/04/16
20160222106 
 Anti-cd38 antibodies for treatment of acute myeloid leukemia patent thumbnailAnti-cd38 antibodies for treatment of acute myeloid leukemia
The present invention relates to methods of treatment of acute myeloid leukemia with anti-cd38 antibodies.. .
Janssen Biotech, Inc.


07/28/16
20160214978 
 Substituted pyrimidine bmi-1 inhibitors patent thumbnailSubstituted pyrimidine bmi-1 inhibitors
Amine substituted pyrimidine compounds and forms thereof that inhibit the function and reduce the level of b-cell specific moloney murine leukemia virus integration site 1 (bmi-1) protein and methods for their use to inhibit bmi-1 function and reduce the level of bmi-1 to treat a cancer mediated by bmi-1 are described herein.. .
Ptc Therapeutics, Inc.


07/28/16
20160214934 
 Substituted indole mcl-1 inhibitors patent thumbnailSubstituted indole mcl-1 inhibitors
The present application, among other things, provides compounds that are capable of inhibiting the activity of anti-apoptotic bcl-2 family proteins, for example, myeloid cell leukemia-1 (mcl-1) protein. The present invention also provides pharmaceutical compositions as well as methods for using provided compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of mcl-1 protein.
Vanderbilt University


07/21/16
20160208010 
 Anti-human cd52 immunoglobulins patent thumbnailAnti-human cd52 immunoglobulins
The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human cd52. The present invention further relates to a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain.
Genzyme Corporation


07/14/16
20160201141 
 Wt1 mutations for prognosis of myeloproliferative disorders patent thumbnailWt1 mutations for prognosis of myeloproliferative disorders
The invention provides methods for determining the prognosis of a patient diagnosed with a leukemia, including b-cell chronic lymphocytic leukemia, by measuring mutations of the wt1 gene in a biological sample. The invention also relates to the diagnosis of leukemia, including b-cell chronic lymphocytic leukemia..
Quest Diagnostics Investments Incorporated


07/14/16
20160200816 

Methods of manipulating phagocytosis mediated by cd47


Methods are provided to manipulate phagocytosis of cancer cells, including e.g. Leukemias, solid tumors including carcinomas, etc..
The Board Of Trustees Of The Leland Stanford Junior University


07/14/16
20160199403 

Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias


Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (all) or a predisposition to all, uses and compositions are disclosed.. .
The Ohio State University Research Foundation


07/07/16
20160194409 

Bispecific cd33 and cd3 binding proteins


Described herein are binding proteins that specifically bind to human cd33, and in particular to bispecific binding proteins that specifically bind to human cd33 and human cd3. Also described herein are bispecific tandem diabodies that bind to cd33 and cd33, and their uses for immunotherapy of cd33+ cancers, diseases and conditions such as acute myeloid leukemia (aml)..
Amphivena Therapeutics, Inc.


07/07/16
20160194381 

Methods and compositions for treatment of retinoid-responsive conditions


Methods and composition for treating a retinoid-responsive condition in a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a substance selected from the group consisting of: neutrophil gelatinase-associated lipocalin (ngal), an ngal analog, an ngal stimulator and an analog of an ngal stimulator, to a subject having a retinoid-responsive condition. Retinoid-responsive conditions illustratively include acne, rosacea, psoriasis, promyelocytic leukemia and neuroblastoma..
The Penn State Research Foundation


07/07/16
20160194306 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Celgene Quanticel Research, Inc.


07/07/16
20160194292 

Triazolone compounds and uses thereof


The invention disclosed herein is directed to compounds of formula (1a) and (1b) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocyticδ leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of formula (1a) or (1b), or a pharmaceutically acceptable salt thereof.
Inception 2, Inc.


07/07/16
20160194291 

Styryl quinazoline derivatives as pharmaceutically active agents


The present invention relates to styryl quinazoline derivatives of the general formula (i) and pharmaceutically acceptable solvates, hydrates, salts, regioisomeric and polymorphic forms thereof as well as pharmaceutical compositions containing at least one of the described compounds as pharmaceutically active agent. The compounds have been identified as new drug candidates for the prevention and/or treatment of diseases related to disfunction(s) of hematopoiesis and cancer or any other form of neo- or hyperplasias related to fms-like tyrosine kinase 3 (flt3) containing internal tandem duplications (itd), especially in the case of myeloid leukemia.
Vichem Chemie KutatÓ Kft.


06/30/16
20160184380 

Molecular combinations for cancer or other disease treatment


A method and medicine for treating leukemia or other cancer or disease condition including administering periodic doses of a combination of one or more of emodin, rhein or rhapontin with one or more of aucubin, digoxin or beta-sitosterol, and/or one or more of carvacrol, vanillic acid or sitosterol.. .

06/30/16
20160184379 

Molecular combinations for cancer or other disease treatment


A method and medicine for treating leukemia or other cancer or disease condition including administering periodic doses of a combination of one or more of emodin, rhein or rhapontin with one or more of aucubin, digoxin or beta-sitosterol, and/or one or more of carvacrol, vanillic acid or sitosterol.. .

06/30/16
20160184319 

Method of treating mixed lineage leukemia gene-rearranged acute lymphoblastic leukemias


The present invention relates to a method of treating a warm-blooded animal, especially a human, having mixed lineage leukemia (mll rearranged all) comprising administering to said animal a therapeutically effective amount of a staurosporine derivative, especially pkc412 or a pharmaceutically acceptable salt thereof, alone or in combination with further therapeutic measures, for example, those defined herein; to the use of a staurosporine derivative for the preparation of a medicament for the treatment of mll rearranged all; and to a commercial package comprising a staurosporine derivative together with instructions for its use in the treatment of mll rearranged all.. .

06/23/16
20160176978 

Methods of manipulating phagocytosis mediated by cd47


Methods are provided to manipulate phagocytosis of cancer cells, including e.g. Leukemias, solid tumors including carcinomas, etc..

06/23/16
20160176976 

Methods of manipulating phagocytosis mediated by cd47


Methods are provided to manipulate phagocytosis of cancer cells, including e.g. Leukemias, solid tumors including carcinomas, etc..

06/23/16
20160176876 

2-substituted imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer


The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumour cells or non-small cell lung cancer cells.. .

06/23/16
20160175331 

Treatment of leukemia with artemisinin derivatives and combinations with other antineoplastic agents


Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and second agents are detailed herein. The artemisinins include artesunate, dihydroartemisinin, artemether, arteether, artelinate, and art-838.

06/23/16
20160175320 

Compositions, methods and kits for treating cancer


Compositions, kits and methods for treating leukemia in a subject (e.g., human) include a first anti-cancer drug consisting of: Δ12-prostaglandin j3 or a derivative thereof, or a prostaglandin d receptor (dp) agonist. The compositions may further include a second anti-cancer drug.

06/23/16
20160175293 

Pim kinase inhibitor combinations


The present invention relates to a pim kinase inhibitor compound that can be used alone or in a pharmaceutical combination. One such combination comprises (a) a jak inhibitor compound, (b) a pim kinase inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of a myeloid neoplasm or leukemia; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of myeloid neoplasm or leukemia; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a mammal, especially a human..

06/16/16
20160168121 

Quinoline derivative


A compound represented by general formula (i) has a strong axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.. .
Ono Pharmaceutical Co., Ltd.


06/16/16
20160166579 

Combination methods for treating cancers


Or a pharmaceutically acceptable salt thereof; in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer and may not respond to either agent administered as a sole therapy.

06/09/16
20160159739 

Azacyclic constrained analogs of fty720


Small molecules comprised of azacyclic constrained analogs of fty720 are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, leukemia, and other diseases.
The Regents Of The University Of California


06/09/16
20160158245 

Pharmaceutical formulation containing thienotriazolodiazepine compounds


A method of treating lymphoblastic leukemia, acute myeloid leukemia, bcr-abl positive acute lymphoblastic leukemia or cd34 positive acute myeloid leukemia comprising the step of administering to a patient a pharmaceutically acceptable amount of a composition comprising a thienotriazolodiazepine compound according to formula (1) as a solid dispersion wherein x is a halogen, r1 is c1-c4 alkyl, r2 is c1-c4 alkyl, a is an integer of 1-4, r3 is c1-c4 alkyl, c1-c4 hydroxyalkyl, c1-c4 alkoxy, phenyl optionally having substituent(s), or heteroaryl optionally having substituent(s), a pharmaceutically acceptable salt thereof or a hydrate thereof; and a pharmaceutically acceptable polymer. In one embodiment, the pharmaceutically acceptable polymer is hpmcas..
Oncoethix Gmbh


06/09/16
20160158219 

Use of an h4 agonist molecule to treat acute leukemia


The present invention relates to the use of new chemical substances, the levogyre and dextrogyre enantiomers of (amino-7 triethoxy-4, 5, 6 oxo-1 dihydro-1, 3 isobenzofurannyl-3)-1 methoxy-8 methyl-2methylenedioxy-6, 7 tetrahydro-, 2, 3, 4 isoquinoleine or tritoqualine, to treat acute myeloid or lymphoid leukemia, with the exception of type b leukemia.. .
Chrysalis Pharma


06/02/16
20160152724 

A new fusion protein to target and treat acute myloid leukemia cells


A polypeptide which binds to the surface of aml blast cells and is internalised upon binding to the aml blast cells.. .
Rheinisch-westfaelische Technische Hochschule Aachen


05/26/16
20160146788 

Method for screening drugs for treating/preventing myelodysplastic syndrome, etc.


(b) a step of selecting the test substance as a candidate for a therapeutic or prophylactic drug for acute myeloid leukemia or myelodysplastic syndrome and the like when the colony number in the presence of the test substance increases from the colony number in the absence of the test substance.. .

05/26/16
20160145692 

Methods and compositions involving lincrna and leukemia


The instant disclosure relates to the finding that lincrna expression is associated with particular cytogenetic abnormalities and is related to disease pathogenesis of certain cancers. Long intergenic non-coding rnas (lincrnas) have been found to play a role in gene regulation, but their expression has not been described in b acute lymphoblastic leukemia (b-all).
The Regents Of The University Of California


05/26/16
20160145337 

Cd19 specific chimeric antigen receptor and uses thereof


The present invention relates to chimeric antigen receptors (car). Cars are able to redirect immune cell specificity and reactivity toward a selected target exploiting the ligand-binding domain properties.
Cellectis


05/26/16
20160145264 

Novel lipophilic n-substituted norcantharimide derivatives and uses thereof


Novel n-substituted norcantharimide derivatives are disclosed herein. The novel n-substituted norcantharimide derivatives are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly for treating leukemia..
Mackay Memorial Hospital


05/26/16
20160145258 

Inhibitor crystalline form and preparation method and use thereof


The present invention relates to a new crystalline forms of the inhibitor, 5-fluoro-3-phenyl-2-[(s)-1-(9h-purin-6-ylamino)-propyl]-3h-quinazoline-4-one; the new crystalline form, compared to known forms, has one or more improved properties. The present invention also relates to a method for preparing a new crystalline form of 5-fluoro-3-phenyl-2-[(s)-1-(9h-purin-6-ylamino)-propyl]-3h-quinazolin-4-one, a pharmaceutical composition thereof and a use thereof in preparation of a pharmaceutical for the treatment and/or prevention of diseases such as chronic lymphocytic leukemia and indolent non-hodgkin's lymphoma..
Hangzhou Pushai Pharmaceutical Technology Co., Ltd.


05/26/16
20160145206 

N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use


The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (copd); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as behçet's disease.
Pimco 2664 Limited


05/19/16
20160138115 

Methods and characteristics for the diagnosis of acute lymphoblastic leukemia


Methods for identification of leukemia or a genetic predisposition to leukemia are provided that are particularly applicable to acute lymphoblastic leukemia (all). A novel heterozygous germline variant, c.547g>a (p.gly183ser) in the octapeptide domain of pax5, is used to identify those individuals with an enhanced risk or predisposition to all..
Memorial Sloan-kettering Cancer Center


05/19/16
20160137630 

Induction of gata2 by hdac1 and hdac2 inhibitors


Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with gata2 deficiency, particularly diseases or disorders that involve any type of hdac1 and/or hdac2 expression. Such diseases include acute myeloid leukemia (aml); familial myelodysplastic syndrome (mds); leukemia; sickle-cell anemia; beta-thalassemia; monocytopenia and mycobacterial infections; dendritic cell, nonocyte, b, and natural killer lymphoid deficiency; emberger syndrome; asymptomatic neurocognitive impairment; mild neurocognitive disorder; and hiv-associated dementia..
Acetylon Pharmaceuticals, Inc.


05/19/16
20160136218 

Molecular and herbal combinations for disease therapy


A method and medicine for treating leukemia or other cancer includes administering to a patient diagnosed with leukemia or other cancer a treatment regimen that includes periodic doses of a combination including emodin or digoxin, or both, with sheng di huang or da huang, or both, and/or jin yin hua.. .
Sirbal Ltd.


05/12/16
20160131654 

Diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma


The invention generally provides improved compositions and methods for detecting, diagnosing, prognosing, and monitoring multiple myeloma, chronic lymphocytic leukemia, or b-cell non-hodgkin lymphoma in a subject. In particular, the invention provides methods for detecting bcma in subjects to reliably diagnose, predict survival, or monitor multiple myeloma, chronic lymphocytic leukemia, or b-cell non-hodgkin lymphoma in the subject..
Institute For Myeloma & Bone Cancer Research


05/12/16
20160130665 

Prognostic methods and systems for chronic lymphocytic leukemia


The present invention provides systems useful for risk stratification of chronic lymphocytic leukemia (cll) patients. The systems can include a microarray and a decision tree having steps for stratification of one or more cll patients into prognostic groups.
Cancer Genetics, Inc.


05/12/16
20160130659 

Compositions and methods for treating cancer


The instant invention relates to methods for the treatment of b-cell lymphomas and leukemia by administering a syk inhibitor. In another embodiment, the invention relates to a method for treating a patient diagnosed with a b-cell lymphoma or leukemia, comprising administering a syk inhibitor, wherein the b-cells of said patient to be treated are characterized by elevated expression levels of cd86..
Merck Sharp & Dohme Corp.


05/12/16
20160130582 

Oligonucleotide modulators of b-cell cll/lymphoma 11a (bcl11a) and uses thereof


The present invention provides, among other things, oligonucleotide modulators (e.g., inhibitors) of b cell lymphoma/leukemia 11a (bcl11a) and improved methods and composition for treating bcl11a-related diseases, disorders or conditions based on such modulators.. .
Roche Innovation Center Copenhagen A/s


05/12/16
20160130317 

Il-12 immunotherapy for cancer


Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems.
University Health Network




Leukemia topics: Myelogenous, Myelogenous Leukemia, Proliferative, Autoimmune, Stem Cells, Breast Cancer, Rheumatoid Arthritis, Myeloid Leukemia, Acute Myelogenous Leukemia, Lymphocytic, Chronic Lymphocytic Leukemia, Lymphocytic Leukemia, Epigenetic, Multiple Myeloma, Polyphenol

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This listing is a sample listing of patent applications related to Leukemia for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Leukemia with additional patents listed. Browse our RSS directory or Search for other possible listings.


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