Leukemia

Leukemia-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Cd33 specific chimeric antigen receptors for cancer immunotherapy
May 25, 2017 - N°20170145094

The present invention relates to chimeric antigen receptors (car) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scfv derived from a cd33 monoclonal antibody, conferring specific immunity against cd33 positive cells. The engineered immune cells endowed with such cars are particularly ...
NEW Crystalline forms and processes for the preparation of cannabinoid receptor modulators
May 25, 2017 - N°20170144993

The present invention relates to crystalline forms of (1as,5as)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1h-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((s)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid cb2 receptor and are therefore useful in the treatment of cb2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory ...
Differential cerebrospinal fluid reactivity to pfdn5-alpha for detection of b-cell acute lymphoblastic leukemia
Amrita Vishwa Vidyapeetham
May 18, 2017 - N°20170138948

A method of managing treatment in a patient with b-cell acute lymphoblastic leukemia (b-all) for central nervous system (cns) leukemia is disclosed. The method comprises obtaining cerebrospinal fluid (csf) from the patient, obtaining a cell proteome including pfdn5-α from the patient, detecting reactivity of csf against the pfdn5-α, comparing reactivity profile of csf against ...
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Il-12 immunotherapy for cancer
University Health Network
May 18, 2017 - N°20170136072

Compositions and methods far delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.
Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity
The University Of North Carolina At Chapel Hill
May 18, 2017 - N°20170136043

Uses of pyrrolopyrimidines with anti-mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against mertk−/− tumors and itd and tkd mutant forms of acute myeloid leukemia (aml)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
Method and kit for detection of deltanoid-resistant leukemia cells and antibody for use therein
Wroclawskie Centrum Badan Eit+ Sp. Z O.o.
May 11, 2017 - N°20170131281

The present invention relates to a method and a kit and antibodies utilized therein, allowing to distinguish between leukemia cells resistant to and leukemia cells susceptible to differentiation induced by deltanoids.
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Administration of angiocidin for the treatment of cancer
Temple University-of The Commonwealth System Of Higher Education
May 11, 2017 - N°20170128525

Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorigenicity and to confer a non-tumor or healthy phenotype.
Combination therapy for cancer
Celgene Corporation
May 11, 2017 - N°20170128448

Provided herein are methods of treating, preventing and/or managing lymphomas and leukemias by administering to a patient compound a (3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione), or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, in combination with an anti-cd20 antibody or ibrutinib, or a pharmaceutically acceptable salt or solvate thereof
Risk-stratification of b-precursor acute lymphoblastic leukemia patients
Amgen Inc.
May 04, 2017 - N°20170122947

The present invention relates to a method for risk-stratifying subjects suffering from b-precursor acute lymphoblastic leukemia (all), wherein said subjects are intended for a therapy comprising administration of a cd3 binding domain. Risk-stratification is based on the determination of the amount blast cells in a bone marrow sample from said subject, and/or on the determination of the number of ...
Anti-human chemokine (c-c motif) receptor 4 immunotoxins
The General Hospital Corporation
May 04, 2017 - N°20170121419

Anti-human chemokine (c—c motif) receptor 4 immunotoxins and methods of use thereof, e. G., for depleting tregs as an immunotherapy for the treatment of cancer; for the treatment of cancers associated with ccr4+ tumor cells such as skin homing cutaneous t cell lymphoma, adult t cell leukemia/lymphoma, and acute t-cell lymphoblastic leukemia; and for the depletion of cccr4+ ...
Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4...
Sunesis Pharmaceuticals, Inc.
May 04, 2017 - N°20170119745

Methods of treating, preventing or managing hematologic disorders, such as leukemia are disclosed. The methods encompass the administration of sns-595. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. In certain embodiments, the method of treatment comprise administering sns-595 in combination with ara-c. Pharmaceutical compositions and single unit dosage forms ...
Low calcemic, highly antiproliferative, analogs of calcitriol
The Johns Hopkins University
April 27, 2017 - N°20170114013

The disclosure provides compounds, compositions and methods using these compounds and compositions to stimulate the differentiation of cells and inhibit excessive cell proliferation of certain cells, including cancer cells and skin cells, which may be useful in the treatment of diseases characterized by abnormal cell proliferation and/or cell differentiation such as leukemia, myelofibrosis and psoriasis without the well known ...
A composition for use in treating or preventing viral or bacterial infections in a subject ...
The Johns Hopkins University
April 27, 2017 - N°20170112883

A composition for use as adjunctive therapy to antitumor chemotherapeutic treatments, acquired immunodeficiency syndrome treatments and leukemia treatments is described. The composition includes a strain of bacteria lactobacillus reuteri lre 03 dsm 23879 which is able to strongly stimulate the production of pro-inflammatory cytokines (th1) interferon inf-gamma, the cytokines exhibiting a marked antiviral and/or antibacterial activity, and/or a bacterial strain ...
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  • 157+ full patent PDF documents of Leukemia-related inventions.
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  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Peptidomimetic macrocycles as modulators of mcl-1
Aileron Therapeutics, Inc.
April 20, 2017 - N°20170107252

The disclosed peptidomimetic macrocycles modulate the activity of mcl-1. Myeloid cell leukemia 1 (mcl-1) is a protein that inhibits cell death. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which mcl-1 is over-expressed, such as cancer. In particular, mcl-1-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance ...
New biomarker for outcome in aml patients
UniversitÉ D'aix Marseille
April 13, 2017 - N°20170102389

The present invention relates to a method for predicting the survival time of a patient suffering from acute myeloid leukemia (aml) comprising i) determining in a sample obtained from the patient the expression level of nkp46 ii) comparing the expression level determined at step i) with its predetermined reference value and iii) providing a good prognosis when the expression level ...
Modulating gamma-c-cytokine activity
Bioniz, Llc
April 13, 2017 - N°20170101452

Embodiments relate to peptide antagonists of γc-family cytokines, which is associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (gvhd). Thus, inhibitors of γc-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. Traditional approaches to inhibiting γc-cytokine ...
Nucleoside derivatives for the treatment of cancer
Idenix Pharmaceuticals Llc
April 13, 2017 - N°20170101431

Provided herein are compounds, compositions, and methods for the treatment of cancer, including leukemia. In one embodiment, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.
Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a btk inhibitor
Acerta Pharma B.v.
April 06, 2017 - N°20170095471

Therapeutic methods of treating chronic lymphocytic leukemia (cll) and small lymphocytic leukemia (sll) are described. In certain embodiments, the invention includes therapeutic methods of treating cll and sll using a btk inhibitor. In certain embodiments, the invention includes therapeutic methods of treating subtypes of cll and sll using a btk inhibitor, including subtypes of cll in patients sensitive to thrombosis ...
Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
Celgene Corporation
April 06, 2017 - N°20170095464

Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as revlimid® or lenalidomide. The invention further relates to methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the ...
T cell receptor-like antibodies specific for a wti peptide presented by hla-a2
Eureka Therapeutics, Inc.
March 30, 2017 - N°20170088630

The present invention provides antigen binding proteins that specifically bind to wilms' tumor protein (wt1), including humanized, chimeric and fully human antibodies against wt1, antibody fragments, chimeric antigen receptors (cars), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to hla-a0201-restricted wt1 peptide. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment ...
Quinoline derivative
Ono Pharmaceutical Co., Ltd.
March 30, 2017 - N°20170088542

A compound represented by general formula (i) has a strong axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, ...