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Leukemia patents



      
           
This page is updated frequently with new Leukemia-related patent applications. Subscribe to the Leukemia RSS feed to automatically get the update: related Leukemia RSS feeds. RSS updates for this page: Leukemia RSS RSS


Date/App# patent app List of recent Leukemia-related patents
05/28/15
20150148538
 Use of an h4 agonist molecule to treat acute leukemia patent thumbnailnew patent Use of an h4 agonist molecule to treat acute leukemia
The present invention relates to the use of new chemical substances, the levogyre and dextrogyre enantiomers of (amino-7 triethoxy-4,5,6 oxo-1 dihydro-1,3 isobenzofurannyl-3)-1 methoxy-8 methyl-2methylenedioxy-6,7 tetrahydro-,2,3,4 isoquinoleine or tritoqualine, to treat acute myeloid or lymphoid leukemia, with the exception of type b leukemia.. .
05/28/15
20150148403
 Usp37 inactivation as a treatment for plzf/rara-associated acute promyelocytic leukemia patent thumbnailnew patent Usp37 inactivation as a treatment for plzf/rara-associated acute promyelocytic leukemia
Method of regulating the stability and/or the level of the fusion protein plzf/rara are disclosed. Also disclosed are methods for identifying an agent as a regulator of the stability and/or the level of the fusion protein plzf/rara.
Academia Sinica
05/28/15
20150148307
 Methods and compositions for the prognosis and treatment of relapsed leukemia patent thumbnailnew patent Methods and compositions for the prognosis and treatment of relapsed leukemia
The present invention is directed to methods of prognosing relapsed leukemia in a subject. These methods are based on the detection of one or more relapse-specific gene mutations in a patient sample.
New York University
05/28/15
20150147758
 Dot1 histone methyltransferases as a target for identifying therapeutic agents for leukemia patent thumbnailnew patent Dot1 histone methyltransferases as a target for identifying therapeutic agents for leukemia
The present invention provides polypeptides with histone h3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest.
The University Of North Carolina At Chapel Hill
05/28/15
20150147271
 Targets for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes patent thumbnailnew patent Targets for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes
Methods are disclosed for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes using interleukin 1 receptor accessory protein and other targets.. .
Albert Einstein College Of Medicine Of Yeshiva University
05/21/15
20150141502
 Inhibition of leukemic stem cells by pp2a activating agents patent thumbnailInhibition of leukemic stem cells by pp2a activating agents
A method of inhibiting the growth of leukemic hematopoietic stem cells in a subject with leukemia is described. The method includes administering a therapeutically effective amount of a composition including a compound of formula i: i wherein r1 is independently selected from hydrogen and methyl; r2 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, 4,8-dimethyl-nonyl, non-1-enyl, and nonanyl groups; x is a carboxyl, phosphonic, or sulfonic moiety, and n is an integer from 1 to 6, or a compound of formula ii: ii wherein r1 is a c6-c12 alkyl or c6-c12 alkoxy group; r2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; and r3 is an alkyl or cycloalkyl group; or a pharmaceutically acceptable salt thereof..
Ohio State Innvation Foundation
05/21/15
20150140071
 Kinase inhibitors patent thumbnailKinase inhibitors
The disclosed molecules are inhibitors of bcr-abl and src kinases. The molecules are cytotoxic to gleevec resistant cells.
05/21/15
20150139989
 Antibody recognizing human leukemia inhibitory factor (lif) and use of anti-lif antibodies in the treatment of diseases associated with unwanted cell proliferation patent thumbnailAntibody recognizing human leukemia inhibitory factor (lif) and use of anti-lif antibodies in the treatment of diseases associated with unwanted cell proliferation
The invention relates to antibodies directed against human leukemia inhibitory factor (lif) and to a hybridoma cell line producing said antibodies. The invention also relates to a method for blocking/inhibiting the proliferation of stem cells, and to an in vitro method for the diagnosis of diseases associated with unwanted cell proliferation in a subject or for determining the predisposition of a subject to suffer from said disease associated with unwanted cell proliferation, or for prognosis of average life expectancy of a subject suffering from said disease.
Fundacio Privada Institucio Catalana De Recerca I Estudis Avancats (icrea)
05/14/15
20150133462
 Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias patent thumbnailMethods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias
In one aspect, the invention relates to compositions comprising bcr-abl tyrosine kinase inhibitors and artemisinin analogues, derivatives thereof, or related compounds, which are useful as in treating philadelphia chromosome positive leukemias; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with bcr-abl dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
05/14/15
20150133376
 Evaluation of cancer diagnosis following cancer radiotherapy and potentiation of cancer radiotherapy patent thumbnailEvaluation of cancer diagnosis following cancer radiotherapy and potentiation of cancer radiotherapy
A method for evaluation of cancer diagnosis following cancer radiotherapy, comprising: providing a serum sample of a cancer patient prior to the cancer radiotherapy; and measuring a leukemia inhibitory factor concentration in the serum sample. Also provided is a method for potentiation of cancer radiotherapy, comprising: administrating a leukemia inhibitory factor inhibitor or a leukemia inhibitory factor receptor inhibitor to a subject in need of the cancer radiotherapy..
05/14/15
20150133363

Glut-1 as a receptor for htlv envelopes and its uses


The present application relates to polypeptides derived from the soluble part of the glycoprotein of the enveloped virus of primate t-cell leukemia virus (ptlv), or fragments or variants thereof named receptor binding domain ligands (rbd) selected for their ability to bind specifically to the nutrient transporter glut1.. .
05/14/15
20150132315

Methods to impair hematologic cancer progenitor cells and compounds related thereto


Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (aml), chronic myelogenous leukemia (cml) and chronic lymphoid leukemia (cll). Interleukin-3 receptor alpha chain (il-3rα or cd123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells.
04/30/15
20150119557

In vitro culture conditions for t-cell acute lymphoblastic leukemia/lymphoma


We describe cell culture media for in vitro culture of a human cancer cell of the lymphocyte lineage (e.g., leukemia, lymphoma, or other blasts) or a precursor thereof, especially t-cell acute lymphoblastic leukemia lymphoma (t-all), as well as methods for at least maintenance, propagation, or both of the human cancer cell or its precursor.. .
The Brigham And Women's Hospital, Inc.
04/30/15
20150119326

Administration of angiocidin for the treatment of cancer


Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorigenicity and to confer a non-tumor or healthy phenotype..
Temple University Of The Commonwealth Of Higher Education
04/23/15
20150111858

Method of treatment with prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin in-2-1h-one and derivatives thereof


A prodrug can have a structure of formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition for use in treatment of fungus, cancer, dermatitis, superficial mycoses; inflammation, tinea pedis, tinea cruris, and tinea corporis, trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum, and microsporum canis, candidiasis (moniliasis), candida albicans, tinea (pityriasis) vesicolor, malassezia furfur, acute myeloid leukemia, acute lymphoid leukemia, chronic myelogenous leukemia, lymphoma or multiple myeloma..
The University Of Kansas
04/23/15
20150110774

S100 protein inhibitors for treating leukemia


The present invention relates to a compound, composition and method for reducing or inhibiting the differentiation or development of progenitor blood cells into malignant cells, leukemia cells or physiologically pathological cells. Particularly, the invention describes the use of inhibitors of s100 proteins, including myeloid related proteins.
Universite Laval
04/23/15
20150110714

Diagnosis and treatment of cancer expressing ilt3 or ilt3 ligand


The present invention relates to methods of using the expression of iltl3 ligand or ilt3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ilt3-ligand expressing cancers, such as t-cell acute lymphoblastic leukemia (t-cell acute lymphoblastic leukemia), for example by administering ilt3, the extracellular domain of ilt3 or ilt3fc conjugated to a cytotoxic agent to kill the targeted cancer cell.
The Trustees Of Columbia University In The City Of New York
04/16/15
20150104416

Leukemic stem cell ablation


A method for treating a leukemia patient that is resistant to a thymidine kinase inhibitor (tki) other than imantinib comprising administering a cephalotaxine to said patient until said patient demonstrates a hematological or cytological response to said leukemia.. .
Chemgenex Pharmaceuticals, Inc.
04/09/15
20150099775

Compositions and methods for treating cancers


The present invention relates to compositions and methods for treating of cancer. In some embodiments, the invention relates to the use of agents that can modulate a component in the cdx2-klf4 signaling pathway to treat myelodysplastic syndromes (mds), acute myelogenous leukemia (aml), acute lymphocytic leukemia (all), adult t-cell leukaemia (atll), lymphoma, gastric cancer, multiple myeloma, or combinations thereof, or a condition associated with abnormal activity of the cdx2-klf4 signaling pathway..
Aptose Biosciences Inc.
04/09/15
20150098924

Method for ex-vivo purging in autologous transplantation


The present invention concerns a new method for ex-vivo purging of cells in autologous transplantation, wherein the sample of taken cells is treated with a sufficient amount of a multimeric form of the soluble portion of fasl to kill malignant cells without substantially affecting viability of cells to be transplanted. Autologous stem cell transplantation (asct) following high-dose chemotherapy with or without radiotherapy has become the standard therapy for the majority of patients with large-cell lymphomas, multiple myeloma, and refractory/recidivating hodgkin's disease.
Topotarget Switzerland Sa
04/02/15
20150093355

Method of treatment of philadelphia chromosome positive leukemia


The invention provides a method for the treatment of ph+ leukemia in a patient comprising administering to the patient (i) a bcr-abl tyrosine kinase inhibitor, and (ii) an agent which selectively binds to a cell surface receptor expressed on ph+ leukemic stem cells. The invention further provides for the use of (i) and (ii) in, or in the manufacture of a medicament for, the treatment of ph+ leukemia in a patient; and a composition for the treatment of ph+ leukemia in a patient comprising (i) and (ii); and kits comprising (i) and (ii).
Csl Limited
03/26/15
20150087886

Novel bifunctional metnase/intnase inhibitors and related compositions and methods of treatment of cancer


In preferred embodiments, compounds, compositions and methods of treatment of the invention are used to treat a patient suffering from leukemia (e.g. Acute myeloid leukemia (aml) and related cancers.
03/26/15
20150087663

Substituted aminopyrimidine compounds and methods of use


The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the pi3k enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which pi3k enzymes play a role in leukocyte function, and hyperproliferative disorders associated with pi3k activity, including but not limited to leukemias and solid tumors, in mammals, especially humans..
Calitor Sciences, Llc
03/26/15
20150087658

Substituted aminopyrimidine compounds and methods of use


The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the pi3k enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which pi3k enzymes play a role in leukocyte function, and hyperproliferative disorders associated with pi3k activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
03/26/15
20150086645

Treating leukemia with a whole, leech saliva extract


Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° c.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech.
Biopep Solutions, Inc.
03/26/15
20150086575

B cell surface reactive antibodies


The invention relates to antibodies that are reactive to the cell surface of cd19+ b cells, including b-cell chronic lymphocytic leukemia (b-cll) cells, and compositions and methods for using such antibodies, including in the diagnosis and treatment of disorders associated with cd19+ b cells, such as b-cll.. .
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
03/26/15
20150086521

Medicament for the treatment of acute myeloid leukemia (aml)


The present invention relates to the therapeutic treatment of acute myeloid leukemia (aml). It concerns in particular a novel composition for the treatment of this cancer and an associated therapeutic treatment method.
Erytech Pharma
03/19/15
20150080412

Triazolone compounds and uses thereof


The invention disclosed herein is directed to compounds of formula (i) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of formula (i), or a pharmaceutically acceptable salt thereof.
Inception 2, Inc.
03/19/15
20150080372

Compounds and methods for kinase modulation, and indications therefor


Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of b-raf, b-raf v600e and c-raf-1 protein kinase.
Plexxikon Inc.


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Leukemia topics: Myelogenous, Myelogenous Leukemia, Proliferative, Autoimmune, Stem Cells, Breast Cancer, Rheumatoid Arthritis, Myeloid Leukemia, Acute Myelogenous Leukemia, Lymphocytic, Chronic Lymphocytic Leukemia, Lymphocytic Leukemia, Epigenetic, Multiple Myeloma, Polyphenol

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This listing is a sample listing of patent applications related to Leukemia for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Leukemia with additional patents listed. Browse our RSS directory or Search for other possible listings.
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