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L Amino Acid

L Amino Acid-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Protease-resistant lipidated glp-1 analogs
Medimmune Limited
June 14, 2018 - N°20180162920

The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. A combination of lipidation of certain amino acid residues and substitution of alpha-methyl functionalized amino acids for natural amino acids has been determined to produce protease-resistant peptides..
Process for producing acyl amino acids employing lipases
June 07, 2018 - N°20180155749

Wherein the cell has a reduced fatty acid degradation capacity.. .
Antibodies
Lonza Ltd
June 07, 2018 - N°20180154017

Antibodies having modified constant regions so as to permit conjugation of the antibody to a payload such as a therapeutic agent are described. Preferred antibodies include a mutation at light chain position 180 (positional numbering), most preferably the mutation is to a residue selected from c, k, q, or a non-natural amino acid.
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Nicotinamide compositions and the therapeutic use thereof
Apet Holding B.v.
May 24, 2018 - N°20180140553

The present invention relates to compositions and methods for the prophylaxis or treatment of deficiencies in essential amino acid absorption and metabolism and/or of a pathology or symptom associated there with. In particular the invention concerns the treatment and/or prevention of adhd, add and autism spectrum disorders.
Acyl amino acid production
May 10, 2018 - N°20180127791

A second genetic mutation that enables the cell to decrease glutamate breakdown relative to the wild type cell.. .
Modified aminoacyl-trna synthetase and use thereof
Chugai Seiyaku Kabushiki Kaisha
May 10, 2018 - N°20180127761

The present invention provides modified aminoacyl-trna synthetases (arss) having increased reactivity with n-methyl amino acids compared to natural aminoacyl-trna synthetases. The modified aminoacyl-trna synthetases according to the present invention can aminoacylate trnas with their corresponding n-methyl-substituted amino acids such as n-methyl-phenylalanine, n-methyl-valine, n-methyl-serine, n-methyl-threonine, n-methyl-tryptophan, and n-methyl-leucine more efficiently than natural aminoacyl-trna synthetases.
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Chitosan-derivative compounds and methods of controlling microbial populations
Synedgen, Inc.
May 10, 2018 - N°20180127518

The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans.
Fgf-2 variants having n-terminal deletions and increased receptor selectivity and uses thereof
Hepacore Ltd.
May 10, 2018 - N°20180127475

The present invention relates to the design, manufacture and use of fibroblast growth factor (fgf) polypeptides having improved receptor specificity. In particular, the invention relates to isolated fgf2 and fgf4 polypeptides comprising a truncated n-terminus and optionally n-terminal amino acid substitutions.
Amino acid based amphoteric surfactant
Elé Corporation
May 10, 2018 - N°20180127360

Disclosed is a novel amino acid derived surfactant which is prepared by forming the salt of an alkylaminopropionic acid and a basic amino acid such as arginine which is useful in cosmetic and personal care compositions.. .
Modified cascade ribonucleoproteins and uses thereof
Caribou Biosciences, Inc.
May 03, 2018 - N°20180119121

A clustered regularly interspaced short palindromic repeat (crispr)-associated complex for adaptive antiviral defence (cascade); the cascade protein complex comprising at least crispr-associated protein subunits cas7, cas5 and cas6 which includes at least one subunit with an additional amino acid sequence possessing nucleic acid or chromatin modifying, visualising, transcription activating or transcription repressing activity. The cascade complex with additional activity ...
Compositions and methods for diagnosing and treating autoimmune diseases
The Regents Of The University Of Colorado, A Body Corporate
May 03, 2018 - N°20180118801

Disclosed are compositions and methods for detecting, isolating, and/or characterizing a t cell or autoantibody associated with type i diabetes. The composition and methods comprise the use of a hybrid insulin peptide having an n-terminal amino acid sequence taken from the human insulin peptide and a c-terminal amino acid sequence taken from a secretory granule protein that are joined ...
Antifungal composition/treatment
The University Of Nottingham
May 03, 2018 - N°20180117082

An antifungal composition comprising an agent that affects the availability of functional amino acids and either i) another agent that affects the availability of functional amino acids or ii) an aminoglycoside antibiotic.. .
Benefit delivery particle and composition comprising the particle
Conopco, Inc., D/b/a Unilever
May 03, 2018 - N°20180116918

Disclosed is a benefit agent delivery particle comprising a benefit agent; and a chitosan salt at the outer surface of the particle, wherein the chitosan salt comprises a chitosan component and amino acid anion, wherein the amino acid comprises phenylalamine; the amino acid does not comprises tyrosine; and the amino acid does not comprises histidine or the amino acid comprises ...
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Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof
Biontech Ag
April 05, 2018 - N°20180094059

The present invention relates to a polypeptide comprising a component a with at least three tumor necrosis factor (tnf) homology domains of tnf-ligand family members (thd) in which c-terminal and n-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional c-terminal and/or n-terminal amino acids of the thd or variants thereof, and ...
N-acyl amino acid compounds and methods of use
April 05, 2018 - N°20180093984

Or a salt thereof, wherein r1, a, l, and r2 and n are as described herein. Compounds of formula (i) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis..
Implantable intestinal reactor
Centre Hospitalier Universitaire Grenoble
March 22, 2018 - N°20180078746

The device, that can be implanted in the intestinal cavity, comprises a reactor comprising a semi-permeable or porous membrane or coating linked to a element for attachment to an intestinal or gastric wall. The reactor can be in the form of a ribbon, a structure having more than two faces or an open structure delimiting a lumen, comprising, or formed ...
Expression vectors for an improved protein secretion
Basf Se
March 15, 2018 - N°20180073005

The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein.
Enkephalin-influencing composition and method
Bioadatp, Llc
March 15, 2018 - N°20180071246

A composition which includes phenylalanine, serine, glutamine and gaba (γ-aminobutyric acid). The composition contains the essential amino acids phenylalanine; glutamine; the non-essential amino acid serine; and gaba (γ-aminobutyric acid) in concentrations effective to influence or modulate the neurotransmitter pentapeptide enkephalin.
Tyrosinase activity inhibitor and external preparation for skin
Jo Cosmetics Co., Ltd.
March 15, 2018 - N°20180071239

A tyrosinase activity inhibitor is prepared by combining (a) a metal (zinc, cobalt or iron) chelate compound of α-lipoyl amino acid or its pharmaceutically acceptable salt with (b-1) a human manganese sod or (b-2) an ascorbic acid compound such as ascorbic acid and ascorbyl glucoside. A ratio (r1) of the (b-1) component content to the (a) component content ...
Functionally modified polypeptides and radiobiosynthesis
Ikaria Inc.
March 08, 2018 - N°20180066298

Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnaas) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum albumin. Methods of substituting a non-natural amino acid in a first polypeptide to obtain a modified polypeptide, the nnaa in some instances comprising an albumin targeting group, are disclosed, ...
Herbicide-resistant protein, encoding gene and use thereof
Beijing Dabeinong Biotechnology Co., Ltd.
March 08, 2018 - N°20180066275

Involved is a herbicide-resistant protein, coding gene and use thereof. The herbicide-resistant protein comprises: (a) a protein consisting of an amino acid sequence shown in seq id no: 2; or (b) a protein with the activity of herbicide-resistance which is derived from the amino acid sequence in (a) by replacing and/or deleting and/or adding one or several amino acids ...
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