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Kinetics-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

Antibodies against p97 and conjugates thereof
Bioasis Technologies, Inc.
January 11, 2018 - N°20180009898

Provided are conjugates between (a) an antibody or antigen-binding fragment thereof that binds to p97 (melanotransferrin; mtf) and (b) an agent of interest, and related compositions and methods, for example, to improve pharmacokinetics and/or delivery of the agent of interest across the blood-brain barrier (bbb) and into tissues of the central nervous system (cns).
Anti-c5 antibodies having improved pharmacokinetics
Alexion Pharmaceuticals, Inc.
January 11, 2018 - N°20180009885

The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e. G., the assembly and/or activity of the c5b-9 tcc) and c5a anaphylatoxin-mediated inflammation and, thus, treating complement-associated disorders. The antibodies have a number of improved properties relative to eculizumab, including, e. G., increased serum half-life in a human.
Adsorbent comprising bisphenol, formaldehyde and hexadiamine terpolymer with adsorbed pb
King Fahd University Of Petroleum And Minerals
January 11, 2018 - N°20180009679

A cross-linked terpolymer (bsdf) obtained by polycondensation of bisphenol-s, formaldehyde and 1,6-diammohexane. The terpolymer is highly efficient in eliminating lead ions from aqueous solutions. The adsorption of lead ions on bsdf was studied under different conditions such as: ph, contact time and temperature. The adsorption kinetics fits lagergren second order kinetic model that are in agreement with the low surface ...
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Mesoporous nanocrystalline film architecture for capacitive storage devices
The Regents Of The University Of California
January 04, 2018 - N°20180005770

A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can ...
Multi-functional composition of matter for rapid removal of mercury from a flue gas
Ada Carbon Solutions, Llc
January 04, 2018 - N°20180001257

A multi-functional composition of matter that is useful for injection into a flue gas stream to rapidly and efficiently remove mercury from the flue gas stream. The multi-functional composition of matter may include a fixed carbon sorbent and minerals, halogens in the form of halide salts, as well as other physical and chemical properties to enhance (1) the oxidation reaction kinetics ...
Method and process for quantitative evaluation of pharmacokinetics, therapeutic effects and safety of delivery of ...
Massachusetts Institute Of Technology
January 04, 2018 - N°20180000956

The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.
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Nucleic acid-based linkers for detecting and measuring interactions
President And Fellows Of Harvard College
December 28, 2017 - N°20170369935

The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first, ...
Drug delivery system for delivery of acid sensitivity drugs
Dsm Ip Assets B.v.
December 28, 2017 - N°20170367992

The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer x which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer y. The hydrolytic degradable polymers x and y are different polymers. Polymer x further comprises amino-acids ...
Activation system and method for enhancing metal recovery during atmospheric leaching of metal sulfides
Flsmidth A/s
December 14, 2017 - N°20170356063

A method of improving metal leach kinetics and recovery during atmospheric or substantially atmospheric leaching of a metal sulfide is disclosed. In some embodiments, the method may comprise the step of processing a metal sulfide concentrate in a reductive activation circuit 220 that operates at a first redox potential, to produce a reductively-activated metal sulfide concentrate. The method may further comprise ...
Catalytic effects of oxygen carrier based chemical-looping reforming of ch4 with co2
University Of Wyoming
December 14, 2017 - N°20170354958

The invention relates to ceo2 and la2o3 for catalyzing fe2o3—al2o3 based chemical-looping reforming of ch4 with co2 (cl-drm). The reaction performance of all the composite oxygen carriers was evaluated in a fixed-bed reactor at atmospheric pressure condition. The influencing factors, including temperature and time-on-stream (tos) were investigated. The characteristics of the oxygen carriers were checked ...
Dihydroindolizinone derivative
Ono Pharmaceutical Co., Ltd.
December 07, 2017 - N°20170349580

A compound represented by general formula (i) (wherein all symbols are as defined in the description) or a salt, solvate, n-oxide form or prodrug thereof is a potent fxia inhibitor, has excellent oral absorption properties and kinetics in blood, can exert a potent anti-coagulation activity over a long period of time after being administered orally, and has a discrepancy between ...
Crystalline n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n- methyl-2-[4-(2-pyridinyl)phenyl]acetamide ...
Aicuris Anti-infective Cures Gmbh
December 07, 2017 - N°20170348297

The present invention relates to the crystalline mono mesylate monohydrate salt of n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide in a definite particle size range, particle size distribution and a specific surface area range, which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions, as well as to pharmaceutical compositions containing ...
Industrial heating apparatus and method employing fermion and boson mutual cascade multiplier for beneficial material ...
Mhi Health Devices, Llc.
November 30, 2017 - N°20170347440

Presented is a simple, but highly energy efficient industrial heating device and method for rapid heating and high temperature gradient production whereby fermions and bosons are introduced into an adjoining fluid which may be boundary layered and consequently produce an amplifiable activated condition even at room pressure and high temperature. This heating device uses a comparatively long current carrying member ...
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Controlled release dosage form with enhanced pharmacokinetics
Osmotica Kereskedelmi Es Szolgaltato Kft
November 30, 2017 - N°20170340570

The present invention provides a simple and improved dosage form that is capable of providing a controlled release of gabab receptor agonist contained in the core thereof. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to gabab receptor agonist.
Treating fungal infection of the nail unit
Hallux, Inc.
November 30, 2017 - N°20170340565

Described here are various compositions for the delivery active agents, e. G., antifungal agents. The compositions may be beneficial due to the particular release kinetics associated with them. Various locations and methods for placement of the compositions into the tissues of the nail unit, as well as tissues surrounding the nail milt are also described.
Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
Diamedica Inc.
November 30, 2017 - N°20170340559

Provided are high concentration compositions of tissue kallikrein-1 (klk1) and methods of parenterally administering such compositions to a subject in need thereof, where absorption into the circulation via, for example, intravenous or subcutaneous administration improves systemic pharmacokinetics, bioavailability, safety, and/or convenience relative to intravenous or other forms of administration. Also provided are recombinant human klk1 (rhklk1) polypeptides that can ...
Optimization of the cerium-hydrogen redox flow cell
The Regents Of The University Of California
November 23, 2017 - N°20170338508

The ce—h2 redox flow cell is optimized using commercially-available cell materials. Cell performance is found to be sensitive to the upper charge cutoff voltage, membrane boiling pretreatment, methanesulfonic-acid concentration, (+) electrode surface area and flow pattern, and operating temperature. Performance is relatively insensitive to membrane thickness, cerium concentration, and all features of the (−) electrode including hydrogen flow. Cell ...
Ucl Business Plc
November 23, 2017 - N°20170334964

The present invention provides a variant proliferation-inducing ligand (april), which has a higher binding affinity to bcma than wild-type april; and/or altered binding kinetics compared with wild-type april, and/or a higher bcma:taci (transmembrane activator and calcium modulator and cyclophilin ligand interactor) binding ratio than wild-type april and which comprises mutations at one or more of the following ...
N-substituted 4-aminoquinazoline derivatives and methods of use
Codexis, Inc.
November 23, 2017 - N°20170334886

The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides lapatinib analogs that provide therapeutic benefits.
Population pharmacokinetics of liposomal irinotecan
Codexis, Inc.
November 23, 2017 - N°20170333421

Analysis identified pk factors associated with efficacy, safety, and predictive baseline factors. The results support the benefit of nal-iri dose of 70 mg/m2 (free base; equivalent to 80 mg/m2 salt base) q2w over 100 mg/m2 q3w.
3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
Lasergen, Inc.
November 16, 2017 - N°20170327886

The present invention relates generally to 3′-oh unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to dna and rna sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage ...