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Kinetics

Kinetics-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Light microscopy chips and data analysis methodology for quantitative localzied surface plasmon resonance (lspr) biosensing ...
The Government Of The United States Of America, As Represented By The Secretary Of The Navy
June 14, 2018 - N°20180164309

A chip for localized surface plasmon resonance (lspr) biosensing and imaging having a glass coverslip compatible for use in a standard microscope and at least one array of functionalized plasmonic nanostructures patterned onto the glass coverslip with electron beam nanolithography. The nanostructures can be regenerated allowing the chip to be used multiple times.
Induction of pluripotent cells
The Scripps Research Institute
June 14, 2018 - N°20180163181

The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (ipscs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of ipsc generation from human fibroblasts, within seven days of treatment.
Palladium-platinum system for use as hydrogen storage material and/or electrocatalyst, preferably in fuel-cells
Uniwersytet Warszawski
June 14, 2018 - N°20180162727

The present invention relates to palladium-platinum system consisting of palladium layer covered with a platinum overlayer consisting of 1 to 10 platinum monolayers deposited on palladium for use as hydrogen storage. Such system can be used in fuel cells, hydride batteries and supercapacitors.
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Methods of analyzing nucleic acids
Epicentre Technologies Corporation
May 31, 2018 - N°20180148767

Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use dna reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cdna from rrna), moderately abundant, and less abundant or rare sequences (e.g., cdna from mrna)..
Tetrahydroisoquinoline derivatives
Cytokinetics, Incorporated
May 31, 2018 - N°20180148458

Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast ...
Method of modifying isoelectric point of antibody via amino acid substitution in cdr
Chugai Seiyaku Kabushiki Kaisha
May 24, 2018 - N°20180142027

The present inventors provide methods for modifying the isoelectric point of an antibody while retaining its antigen-binding activity, comprising modifying the charge of at least one exposable amino acid residue on the surface of the complementarity determining region (cdr). The present invention also provides methods for purifying multispecific antibodies, comprising modifying isoelectric point, and methods for improving the plasma pharmacokinetics ...
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  • 99+ full patent PDF documents of Kinetics-related inventions.
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Methods and apparatus for a shear-enhanced cnt-assembly nanosensor platform for ultra-sensitive and selective protein detection
University Of Notre Dame Du Lac
May 17, 2018 - N°20180136163

A nanoscale protein-sensing platform with a non-equilibrium on-off switch that employs dielectrophoretic and hydrodynamic shear forces to overcome these thermodynamic limitations with irreversible kinetics. The detection sensitivity is achieved with complete association of the antibody-antigen-antibody (ab-ag-ab) complex by precisely and rapidly assembling carbon nanotubes (cnt) across two parallel electrodes via sequential dc electrophoresis and dielectrophoresis (dep), and with single-cnt electron ...
Systems and methods for performing a condition-based maintenance of an engine
General Electric Company
May 10, 2018 - N°20180128134

A method for performing condition-based maintenance of an engine is presented. The method includes obtaining one or more parameters corresponding to the engine.
Antibody-vaccine engineered constructs (avec)
Phoenix Biomolecular Engineering Foundation
May 10, 2018 - N°20180126001

Hereby, we disclose and claim, the concept, designs, enabling technologies, and utility for therapy of patients suffering from cancer, of a novel class of biomolecularly engineered, synthetic molecules: antibody-vaccine engineered constructs (avec). They comprise the main functional domains (antibodies and vaccines) and the supporting domains (linkers and reporters).
Treating fungal infection of the nail unit
Hallux, Inc.
May 03, 2018 - N°20180116960

Described here are various compositions for the delivery active agents, e.g., antifungal agents. The compositions may be beneficial due to the particular release kinetics associated with them.
Componential analyzer, drug efficacy analyzer, and analysis method
Hitachi High-technologies Corporation
April 19, 2018 - N°20180106783

Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (basal/basolateral)-side via transporters and by diffusion, one excreted to the lumen (apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the ...
Process for accurately profiling fluid distribution in multi-layer absorbent articles in two and three dimensions
The Procter & Gamble Company
April 19, 2018 - N°20180106737

A process for profiling fluid distribution and analyzing fluid redistribution kinetics in multi-layer absorbent articles is disclosed.. .
Tocopherol and tocopheryl quinone derivatives as correctors of lysosomal storage disorders
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
April 19, 2018 - N°20180105506

The subject invention relates to improved tocopheryl quinine derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of lysosomal storage disorder, restoration of normal mitochondrial atp production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have ...
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  • 99+ full patent PDF documents of Kinetics-related inventions.
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Release-matrices for controlled release of materials into a surrounding medium
Kuhner Shaker Gmbh
March 29, 2018 - N°20180087025

The present invention refers to release matrices which include a material that can be released in a controlled way or with predefined kinetics into a surrounding medium, reaction vessels comprising said release matrices, and release system further comprising a medium which is able to dissolve the embedded material. The present invention further refers to the use of release matrices in ...
Novel tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
Sirna Therapeutics, Inc.
March 22, 2018 - N°20180079769

Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetragalnac ligands of formula (i), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, ...
Inhibition of formation of amyloid b-protein fibrils using cactus mucilage extracts
University Of South Florida
March 22, 2018 - N°20180078595

Alzheimer' s disease (ad) is the common neurodegenerative disorder characterized by the formation of extraneuronal accumulation of amyloid fibrils and intracellular neurofibrillary tangles of amyloid β-protein (aβ) into plaques. Cactus mucilage extracted from opuntia ficus-indica was analyzed in disturbing the aggregation pathway of amyloid β-protein (aβ) fibrils and α-synuclein.
Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
Clarus Therapeutics, Inc.
March 22, 2018 - N°20180078566

A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed.
Sorbents for carbon dioxide reduction from indoor air
Enverid Systems, Inc.
March 15, 2018 - N°20180071672

A sorbent for co2 reduction from indoor air from an enclosed space. In some embodiments, the sorbent comprises a solid support and an amine-based compound being supported by the support.
Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
Clarus Therapeutics, Inc.
March 15, 2018 - N°20180071311

A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed.
Method and system for selecting drug on basis of individual protein damage information for preventing ...
Cipherome, Inc.
March 08, 2018 - N°20180068056

The present invention relates to a method and a system for selecting a drug customized on the basis of individual protein information by using individual genome sequences. The method and the system of the present invention can predict the individual side effects or danger of a certain drug by analyzing the sequence of the exon region of a gene encoding ...
Chimeric antigen receptor
Ucl Business Plc
March 08, 2018 - N°20180064758

The present invention provides a chimeric antigen receptor (car) comprising an antigen-binding domain with an affinity in the range of 50 nm to 500 nm, wherein said affinity comprises component kinetics such that the association rate constant (kon) is greater than or equal to 1×105 m−1 s−1, and/or the dissociation rate constant (koff) is greater than or equal to 0.01 ...
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