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Kinetics

Kinetics-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Novel tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
Sirna Therapeutics, Inc.
October 26, 2017 - N°20170306324

Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetragalnac ligands of formula (i), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, ...
Controlled release and taste masking oral pharmaceutical composition
Cosmo Technologies Limited
October 26, 2017 - N°20170304209

Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i. E. A structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of ...
Use of clonal evolution analysis for ibrutinib resistance in chronic lymphocytic leukemia patients
Cosmo Technologies Limited
October 19, 2017 - N°20170298441

The present invention generally relates to the methods and use of clonal evolution analysis of the kinetics and genetic alterations associated with the development of resistance to a therapy using whole-exome and deep targeted sequencing in treating patients in need thereof.
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Novel compositions that mimic adipose tissue in mri
Qalibremd, Inc.
October 12, 2017 - N°20170293011

Provided herein are adipose mimic compositions for use in mri. The compositions of the invention mimic the mri properties of human adipose tissue, including t1 relaxation kinetics, t2 relaxation kinetics, magnetic susceptibility, and chemical shift artifact. The compositions of the invention are readily manufactured from inexpensive materials. The compositions of the invention may be used in mri system calibration or ...
System and method for enhanced metal recovery during atmospheric leaching of metal sulfides
Flsmidth A/s
October 05, 2017 - N°20170283908

A method of improving metal leach kinetics and recovery during atmospheric or substantially atmospheric leaching of a metal sulfide is disclosed. In some embodiments, the method may comprise the steps of: (a) producing a metal sulfide flotation concentrate; (b) processing the metal sulfide concentrate in a reductive activation circuit that operates at a first redox potential, to produce a reductively-activated ...
Methods and apparatus for single molecule sequencing using energy transfer detection
Life Technologies Corporation
October 05, 2017 - N°20170283868

Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide ...
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  • 99+ full patent PDF documents of Kinetics-related inventions.
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Method and apparatus for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer
Pepsico, Inc.
September 28, 2017 - N°20170276750

Methods for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer are disclosed, including methods to determine an initial amount of a substance, usually a liquid, contained inside a porous material and an initial amount of the substance, usually a liquid, present outside the porous material, methods to measure the release kinetics of a substance, such as a liquid, from ...
Carbon capture solvents having alcohols and amines and methods for using such solvents
Carbon Clean Solutions Limited
September 28, 2017 - N°20170274317

Methods and compositions useful, for example, for physical solvent carbon capture. The solvents may include an aqueous mixture of 2-amino-2-methylproponol, 2-piperazine-1-ethylamine, diethylenetriamine, 2-methylamino-2-methyl-1-propanol, and potassium carbonate or potassium carbonate buffer salt. The solvent may also contain less than about 75% by weight of dissolving medium (i. E., water) and may have a single liquid phase. The solvents ...
Imidazoyl anilide derivatives and methods of use
Codexis, Inc.
September 28, 2017 - N°20170273978

The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides nilotinib analogs that provide therapeutic benefits.
Antiviral azasugar-containing nucleosides
Biocryst Pharmaceuticals, Inc.
September 21, 2017 - N°20170267681

Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral rna polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are ...
Coated particles for drug delivery
Dana-farber Cancer Institute, Inc.
September 21, 2017 - N°20170266123

In one aspect, a particle comprising a core containing at least one pharmaceutically active agent and a coating covering the surface of the particle that comprises a biocompatible adhesive polymer is provided. The core may comprise two or more components, such as two pharmaceutically active agents or a pharmaceutically active agent and a major constituent of the core, having at ...
All natural, non-toxic sublingual drug delivery systems
Sentar Pharmaceuticals, Inc.
September 21, 2017 - N°20170266118

All natural non-toxic sublingual delivery systems improve absorption and onset profiles for numerous actives, along with bioavailability and pharmacokinetics results that are better than expected for families of moieties compounds and legacy-patented formulations.
Low-emitting fiber composite manufacturing process
Neucor Inc.
September 14, 2017 - N°20170259454

A novel green manufacturing process for medium and high-density fiberboard (mdf and hdf) production is disclosed, where the green manufacturing process refers to a novel low-emitting manufacture of mdf and hdf in terms of hap emission. The novel manufacturing process comprises a preconditioning unit operation for raw wood furnish material, where blends comprising two or more woody materials having disparate ...
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Conjugates of porphyrinoid photosensitizers and glycerol-based polymers for photodynamic therapy
Biolitec Unternehmensbeteiligungs Ii Ag
August 31, 2017 - N°20170247384

Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for pdt of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and pdt treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. ...
Novel tetragalnac containing conjugates and methods for delivery of oligonucleotides
Sirna Therapeutics, Inc.
August 17, 2017 - N°20170233731

Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetragalnac ligands of formula (i), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
Method of development and use of catalyst-functionalized catalytic particles to increase the mass transfer rate ...
University Of Kentucky Research Foundation
August 17, 2017 - N°20170232380

The present invention relates to methods for improving carbon capture using entrained catalytic-particles within an amine solvent. The particles are functionalized and appended with a co2 hydration catalyst to enhance the kinetics of co2 hydration and improve overall mass transfer of co2 from an acid gas.
Optical biosensor referencing method
Pall Corporation
August 10, 2017 - N°20170227458

A referencing method for an optical biosensor system using a single sensing region is provided. The method involves limiting the ligand immobilized in a single sensing region to only a portion thereof. In one embodiment, this is accomplished by selectively deactivating a portion of the sensing surface to prevent immobilization of ligand to that portion. As a result, a reference ...
Antibodies with modified affinity to fcrn that promote antigen clearance
Pall Corporation
August 10, 2017 - N°20170226206

The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human fcrn-binding activity at the plasma ph and a lower antigen-binding activity at the early endosomal ph than at the plasma ph; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can ...
Methods for increasing coating strength to improve scaffold crimping yield
Abbott Cardiovascular Systems Inc.
August 10, 2017 - N°20170224880

Methods of reducing crimping damage to polymer and drug coating on a scaffold are disclosed. The methods include physically aging a coating including a coating polymer and drug mixture on a scaffold in a manner that takes into account the differing kinetics of aging, that is, the different temperature dependence of the aging rate of the polymer and drug.
Laser pulse shaping for additive manufacturing
Lawrence Livermore National Security, Llc
August 03, 2017 - N°20170216966

A system for melting powdered material and bonding it to the substrate below such as could be used for the additive manufacturing of a product includes a substrate, powder particles on the substrate, a pulsed laser that produces a pulsed laser beam with one or more low flux components on the order of kw/cm̂2, and one or more ...
Crosslinked polymer nano-assemblies and uses thereof
University Of Massachusetts
August 03, 2017 - N°20170216450

The invention provides a novel system of nano-assemblies and related method for delivery of therapeutic, diagnostic or imaging agent to biological sites. The compositions and methods of the invention enable the syntheses of novel polymeric nano-assemblies (nanoparticles) under non-emulsion conditions with the incorporation of hydrophobic guest molecules. The versatilities and advantages of the polymer nanoparticles of the invention include: (i) ...
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